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Jan 15

Episode 300: AMA! Sleep, Whole Foods, Musical Theater, Bloating, Parasites, Botox, Anti-Aging Skincare, Laser Hair Removal, Favorite Books, And More!

Intermittent Fasting

Welcome to Episode 300 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

BUTCHERBOX: Grass-Fed Beef, Organic Chicken, Heritage Pork, Wild-Caught Seafood: Nutrient-Rich, Raised Sustainably The Way Nature Intended, And Shipped Straight To Your Door! For A Limited Time Go To butcherbox.com/ifpodcast And Get The New Year Bundle For Free Plus $10 Off When You Sign Up Today. That’s A 14 Oz Pork Tenderloin, 2 Lbs Of Ground Turkey, And 4 Top Sirloin Steaks Free In Your First Box!

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To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get The New Year Bundle For Free Plus $10 Off When You Sign Up Today. That’s A 14 Oz Pork Tenderloin, 2 Lbs Of Ground Turkey, And 4 Top Sirloin Steaks Free In Your First Box!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

IF Biohackers: Intermittent Fasting + Real Foods + Life

 Listener Q&A: Nicole - What’s one piece of advice you’d give to someone looking to get healthier? 

Listener Q&A: Samantha - I know you are a musical theater fan, what is your favorite musical?

BLISSY: Get Blissy In Tons Of Colors, And Risk-Free For 60 Nights, At blissy.com/ifpodcast, With The Code IFPODCAST For 30% Off!

Listener Q&A: Alani - What are your tricks for keeping your stomach from puffing out?

Listener Q&A: David - Have either of you taken a DNA stool analysis for parasites?

Episode 296: Berberine, Insulin Sensitivity, Glucose Control, Gut Health, Liver Health, Body Recomposition, AMPK Activation, Cholesterol Control, And More!

Listener Q&A: Amy - Loved last episode where you both admitted you color your hair without shame in not using cleaner options. I would be curious what other things are you willing to “bend” the rules for?

ATHLETIC GREENS: Get A FREE 1 Year Supply Of Immune-Supporting Vitamin D AND 5 FREE Travel Packs With Your First Purchase At athleticgreens.com/ifpodcast.

Listener Q&A: Damon - Laser hair removal, is it worth it?

Listener Q&A: Kimberly - What are your top 3 book recommendations besides your own?

Listener Q&A: Danielle - What is your favorite holiday tradition?

Listener Q&A: Lesley - I work at HOTWORX 24 hour infrared fitness studio. What do you think about a 3d workout? Heat, exercise, infrared sauna?

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 300 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I’m Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting and Wine. I’m here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it’s that time and get ready for The Intermittent Fasting Podcast. 

Hi friends, I’m about to tell you how you can get a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, plus $10 off. Yes, all of that incredible meat, plus $10 off, all for free. We are a bit obsessed with a company called ButcherBox, which is always in season. Some of my favorite meals that I had throughout the holiday season were fantastic meat and seafood from ButcherBox. Now with the new year, it is time to celebrate with only the very best of the best when it comes to meat and seafood that you put in your body, as well as meat and seafood that helps support our planet and the environment.

They make it so, so easy to get high-quality humanely raised meat that you can trust. They deliver 100% grass-fed, grass-finished beef, free-range organic chicken, heritage-breed pork, that’s really hard to find, by the way, and wild-caught sustainable and responsible seafood shipped directly to your door. When you become a member, you’re joining a community focused on doing what’s better for everyone. That includes caring about the lives of animals, the livelihoods of farmers, treating our planet with respect, and enjoying deliciously better meals together. I did so much research on ButcherBox, you can actually check out my blog post all about it at melanieavalon.com/butcherbox.

All of their beef is 100% grass-fed and grass-finished and they work personally with all the farmers to truly support the regenerative agriculture system. I also did an interview with Robb Wolf on my show, The Melanie Avalon Biohacking Podcast, all about the massive importance of supporting regenerative agriculture for the sustainability of not only ourselves but the planet. This is so important to me. I’ll put a link to that in the show notes. The value is incredible. The average cost is actually less than $6 per meal and it’s so easy. Everything ships directly to your door and it is so delicious. I love carpaccio for example. The ButcherBox steaks are incredible for that. That’s how you know it’s good steak when you can eat it rare like that and ButcherBox has an incredible offer for our audience.

You can get the New Year bundle for free, plus $10 off when you sign up today. That’s a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, in your first box. Sign up @butcherbox.com/ifpodcast and use code IFPODCAST to claim this offer. Again, to get a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, plus $10 off, sign up @butcherbox.com/ifpodcast and use code IFPODCAST to claim this offer. We’ll put all this information in the show notes.

One more thing before we jump in, are you fasting clean inside and out. So, when it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you what is possibly one of the most influential factors in weight gain. It’s not your food and it’s not fasting. It’s actually our skincare and makeup. So, as it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disruptors, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we’re using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream.

And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That’s because ladies, when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking. And the effects last for years. 

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That’s why it’s up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies and so much more.

You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my Clean Beauty email list. That’s at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list, so definitely check it out. You can join me in my Facebook group Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you’re thinking of making Clean Beauty and Safe Skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It’s sort of like Amazon Prime for Clean Beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. And we’ll put all this information in the show notes. All right, now back to the show.

Hi, everybody, and welcome. This is Episode number 300 of the Intermittent Fasting Podcast. Very exciting milestone episode here. I'm Melanie Avalon, and I'm here with Cynthia Thurlow. How are you, Cynthia? 

Cynthia Thurlow: I'm doing well despite navigating travel back to small airports. I was laughing/texting with you last night sharing all the insights I was gleaming being stuck in an airport for 7 hours with a long delay. 

Melanie Avalon: Yes, were talking about the food options, healthy or not, fasting or not in airport layovers, so I'm glad you survived. 

Cynthia Thurlow: Yeah, I know it's funny. I'm such an observer as an introvert, like, I just love to people watch. The behaviors that I was watching yesterday intermittently between reading a book, listening to a podcast, reading another book, binging on something on Netflix was just the behavioral patterns. I think people feel a lot of pressure to eat constantly when they're in airports, and I just find that all super fascinating. I think I was chronicling how it doesn't matter what airport I go to. I can generally get a naked burger and a salad and that's typically what I do. 

Actually, the waiter yesterday, it was funny. I got off my flight from LA and Chicago and I was like, okay, plenty of time. I have two and a half hours, I'll be great. I went to a restaurant, got my burger, read a book. I was totally by myself. I was totally in my zone. And then get to my gate and then we realized we've got, like, mechanical problems. I guess pilots and stewards, stewardesses are only allowed to fly for a certain amount of time every day because of the mechanical delay it turned into. We had a different flight crew. It was like a seven hour instead of a two and a half hour time in between flights. I was texting with Melanie and I said, and then, it's not a good sign when United rolls out the cart of snacks. And the cart of snacks was gone in about two minutes. It was amazing. People were clearly, “starving.” But it was hilarious to kind of watch all this unfold. So, I'm just grateful to be home and the fact that I got a decent amount of night's sleep, and it's my last business trip of the year, so no more traveling for a while. 

Melanie Avalon: Yeah. I feel like it definitely speaks to just how much well, A, we're inundated with food and food advertising and accessibility and also how food is really just a pastime. Like, if we're bored, I'm sure people were hungry as well. It's a comfort. It fills the gap of boredom. 

Cynthia Thurlow: Absolutely. I get that, there's no judgment on my part, the psychology behind the way people eat. That's why I always say, like, if you eat enough protein, you're just too full. Even if I had endeavored to eat the bag of Cheez-Its or Goldfish or whatever myriad of stuff they had, I was like, I just grabbed a bottle of water because I was so dehydrated from traveling that I was like, I'll just grab the water, and I'll just try to stay hydrated, and we'll just go from there. 

Melanie Avalon: Yeah, I always fast when traveling. If it was, like, that situation where it was a really long layover, honestly, I would probably still fast. I would probably turn it into a longer fast moment. Just because I don't feel comfortable with lots of food in me and trap. It makes me sluggish and--

Cynthia Thurlow: Yeah, definitely. I wore-- so people will probably be humored. Like, I've got a whole wardrobe of things I wear when I travel so that I can wear layers. So, I'm never cold, because traveling through Chicago, it was actually the airport was quite cold, which actually wasn't a problem. I was like, okay, I got a sweater. I'll just put that on. I had Spanx, like, leggings on all day because they're super comfortable. They weren't comfortable at, like, hour 18. They were definitely [laughs] when my husband picked me up, I was like, there's too much compression on my stomach and I've been doing a lot of sitting. He was like, “What are you trying to tell me?” I said, “You know how I talk about like there are specific things I wear when I travel. This is not the outfit. If I'm doing more than like 14 hours of travel, there's just too much compression on my stomach.” My stomach was like not happy with me at all. 

Melanie Avalon: I can't wear Spanx at all. That's how you don't have GI issues. 

Cynthia Thurlow: Yeah, they're definitely different. They're super comfortable actually. It's just that amount-- it would be like trying to wear like, Lululemon tights all day long and traveling. It's a lot of compression on your gut. 

Melanie Avalon: Well, speaking of--

Cynthia Thurlow: Probably TMI. This is a good segue into our Q&A because it's like there may be a little TMI today. 

Melanie Avalon: So, for listeners, we really wanted to celebrate Episode 300, quite a milestone. There're a lot of episodes, I think actually for every, well, there's only been two other 100 miles markers. So, Episode 100 and Episode 200. I think for both of those we did an AMA episode. So, continuing the tradition going to do and ask me anything. We got so many amazing questions that we're anticipating. This will probably be a part one, part two, maybe a part three. We'll see how it goes. We got so many really great questions in the Facebook Group which people should join, which is IF Biohackers: Intermittent Fasting + Real foods + Life. That's my personal Facebook group. I asked in that group for ask me anything questions and we got so many. What I did was I divided them into categories. I think we'll just alternate between more personal ones, more health and wellness-related ones. We'll just see where it goes. I have a lot of questions. I'm very excited about this. So, Cynthia, should we jump in?

Cynthia Thurlow: Yes, we should. 

Melanie Avalon: I'm thinking we might because I have, like I said, it's by categories, so I might alternate with the lifehack ones and the likes and things like that with the more health related. Here's a good lifehack that's kind of both. And this comes from Nicole. "What's one piece of advice you'd give someone looking to get healthier?"

Cynthia Thurlow: Oh, gosh. I think and it's funny, I was out in LA and I did four podcasts and pretty consistently the one for me is sleep as a foundational element to health for anyone at any stage of life. I would say really investing in high quality sleep and really starting with the foundations. Not necessarily rushing to a supplement, but doing the things that we know improve sleep quality, daily exercise, light exposure in the morning, getting off electronics, wearing blue blockers, making sure you don't eat two to three hours before bed unless you're a unicorn. I think those are the things that I really think about. I think we like to make things very complicated. I always say before you even think about adding a supplement, make sure you're doing the sleep hygiene pieces. Sleeping in a cold, dark room. I sleep with a sleep mask. I keep the thermostat at 65 degrees. In fact, it was funny when I came home last night, it was 69 degrees on our second floor. The first thing I said to my family was, “Oh, we're going to drop the thermostat because I need it at 65.” Everyone was like, “We've been sleeping at a much warmer temperature.” And I'm like, “I can't do that.” So, I would probably say focusing in on sleep first and then adding supplements if you still need additional support. How about you, Melanie?

Melanie Avalon: That's a good one. I'm actually surprised I didn't think of sleep as the first thing. Whenever people ask me what's the most important thing for me to focus on, I think I normally do say sleep. So, I'm really glad you tackled it. I was thinking on the diet side of things and I was really torn between eating whole foods not the store, but like, foods in their whole form, because that's macro-agnostic, but I just think if we just return to eating real food, that can have a profound effect on people's health. I was torn between that and fasting [laughs] surprise, but I actually think I would go the whole foods route.

Cynthia Thurlow: And I think that's really important. I am a huge advocate of saying that it all starts with food, and I see so many people that are quick to embrace the latest fad irrespective of what it's leaning into. I just remind people, if we just keep things simple, focusing in on sleep, eating as nutrient dense foods as you can, I think that's really, really helpful.

Melanie Avalon: Yeah, I obviously think so as well. I think between those two, honestly, if somebody's not addressing those two things and then they address those two things, I think the profound effect it would have on so many people's health would be crazy. You don't even have to be really specific or do like a certain type of diet, but that combined with the sleep, very powerful. 

Cynthia Thurlow: Yeah, absolutely. Keep it simple. I mean if there's one tried-and-true message that I think both of us discuss consistently is keep things simple because if we try to make too many changes all at once, it's overwhelming. It's hard to stay, I hate to use the word compliant, but that's the easiest way to put it. It's hard to be consistent when you're trying to change five things at once. That's what I think most people do. I mean, I certainly have been guilty of it myself, but pick one thing at a time and really lean into it and master it and then move on to something else. 

Melanie Avalon: Okay, here's the fun one and she addressed it to me, but we can both answer it. It's from Samantha. She said, “Melanie, I know you are a musical theater fan. What is your favorite musical?” 

So, I'll go ahead and answer that. I think I might have answered this on another AMA. This question, I always feel mischaracterizes me because my answer is musicals that, it sounds like a cop out, like, “Oh, she doesn't watch musicals because she's listing,” the one that everybody says, but I promise you I listen to so many musicals. But there's a reason that these two musicals are what they are, which is Phantom and Wicked. They're just so amazing. But then my runner ups are next to normal Jekyll & Hyde and Hamilton. I know she said your favorite, but there're so many, and then I have, like 50 million more. How about you, Cynthia? 

Cynthia Thurlow: A few of those I've seen. I grew up in New Jersey, and so my mom really prioritized taking me to Broadway, and so I did that throughout my childhood. For me, I would say Rent I loved. I mean, I still can listen to the music Wicked, I saw that on Broadway with the original cast just by complete happenstance.

Melanie Avalon: Whoa. Okay, I have a question. Oh, I have a question. Did you see it because when it first came out, it was a bomb like it didn't-- Did you see it before it got famous? 

Cynthia Thurlow: No, I saw it afterwards, it was with Kristin Chenoweth and--

Melanie Avalon: So, there was fanfare surrounding it when you saw it, because when it first came out, it did not take off. 

Cynthia Thurlow: Yeah, because it was 2005/2006 somewhere around there, because I was up there for a medical conference, and my girlfriend was like, “We should go see this play.” And I was kind of like, “Okay.” I had no idea what it was really even about. I just saw Hamilton, and I've been wanting to see Hamilton on Broadway for, I don't know, five years and with the pandemic that kind of nixed our ability to do that and that was amazing. To me, I have so much respect and reverence for people that work in the creative arts. I am not the least bit like, don't ask me to sing, don't ask me to act or dance in front of other people. I would be so embarrassed. I'd want to crawl in a hole, but I love to watch really talented people perform. I just have so much respect and admiration because it's so very different than where my zones of genius are.

As I was sitting there watching Hamilton with my husband and my boys, and I was like, “God, I feel so lucky to be in this zone of greatness.” Like, watching these really talented actors and actresses do what they do best.

Melanie Avalon: That is the exact way I feel. 

Cynthia Thurlow: Yeah. I'm the kind of person, I actually get emotional when I'm watching people when they're really, really good at what they do whether it's dancing or singing or a play. I get a little like teary. It's almost like out of total admiration that I'm witnessing their greatness. 

Melanie Avalon: Yeah, no, I feel the same and actually, I had a similar experience. I saw the original cast of Next to Normal. It was one of those things where I went in like you to Wicked like I didn't really know what I was going into and then I was just blown away. Ah, love musicals. 

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Here's another one and this kind of relates to what we were talking about earlier, “What are your tricks for keeping your stomach from puffing out? Do you use Spanx for that?”

Cynthia Thurlow: I mean, I don't generally have issues related to bloating. I'm probably blessed genetically with some of this on my own. Obviously, I no longer get a menstrual cycle, but when I did, when I was sometimes right before my period, and I would feel bloated. Spanx is great for that. There're different layers of levels of Spanx, so it's not all so constrictive you feel like you're going to die. For me, quite honestly, it's finding a balance between protein and vegetables. This is going to sound odd, but I'll kind of layer this in. When I'm eating a very protein dense diet and I'm eating cooked vegetables, I have little to no bloating, but if I go on a salad binge, like, I mean, a lot of raw vegetables, that can sometimes give me a little bit of bloat. I have to kind of moderate that. 

I got most of my bloating quite honestly from gluten and dairy. And now that I don't have those in my diet, it's not as much of an issue. But I can tell you, and I know we have a parasite question in this Google Doc that we're looking at when we talk about parasites. I will tell you about my bloating issues, but generally speaking, not a lot. I think a great deal of that has to do with dietary choices and not overeating. Like, I feel so miserable if I've overeaten or if I've eaten too much food that I just-- I know where my sweet spot is and if I'm kind of leaning into the protein and cook vegetables, I do really well. How about you? 

Melanie Avalon: Yeah, well, first thing I wrote was just suck it in. [both laughs]

Cynthia Thurlow: Well, I mean, here's the other thing before you say the next thing. A lot of people when they talk about bloating, it's really not bloating. It's because their core is not very strong. So, again, I think some of this is just probably innately how I was made. I've always had a pretty strong core and I've always done Pilates. I've always done a lot of core focused work. If you think about your rectus abdominis and your obliques and all these muscles that work together to kind of hold you in and hold you up, if they're not strong, that can contribute to people perceiving that they're having bloating, when it's really just they have muscles that need a little bit of work, if that helps. 

Melanie Avalon: So that's interesting. That writes me of two things. One, I have this childhood memory, I don't know how old I was, I was probably like nine or ten and some aunt commented on my stomach sticking out.

Cynthia Thurlow: Oh, well, sometimes kids have like lordosis and it's not even that their stomach sticking out, it's they have like a swayed lower back. It has nothing to do with the belly sticking out.

Melanie Avalon: That's what the aunt said. She was like, “Oh, this runs in the family or something.” But do you know how traumatic that is to be told that.

Cynthia Thurlow: People sometimes are thoughtless. I just don't realize they're filters off. It's like you could have said that or just not said that and we would have all been okay.

Melanie Avalon: Not to like a nine or ten-year-old, but what's interesting is, I think this is a fun little also lifehack, I feel like a good way to get a good core workout. So, I saw Trans-Siberian Orchestra recently. I realized I have my crazy concert outfit, which is like this really massive spark-- It looks like a dress, but not really because it's a two-piece, so it's like midriff bearing and then it's this massive sparkly dress. You can see it on my Instagram. It's incredible. In any case, I feel like it's a good hack to get a stomach workout if you wear something like that out, because then you're consciously holding in your stomach, like the entire time, unless you forget. But my first tip was just suck it in.

My second tip [laughs] was based on the digestion and finding the diet that works for you. For me, digestive enzymes are game changers for that. Finding a digestive enzyme supplement that works might help. Also, like Cynthia was saying finding the dietary combination a lot of people-- for me low FODMAP works really well and that keeps me not bloated. Also, oh, here's one. If you go carnivore for a lot of people your stomach will probably get very flat. I experienced that. Whenever I do experiment with a time of just meat, there's zero bloating. 

Cynthia Thurlow: Well, when and if we get to the parasite question in this episode, we can talk about this because that's how I knew something was very wrong and very, very wrong. I always say going back to an anti-inflammatory, like a real anti-inflammatory diet can sometimes be partial carnivore or carnivore for a couple of weeks can really be hugely impactful. But I always say just perceiving you have bloating is very different than looking six months pregnant bloating. There's that continuum that I think is important to identify. 

Melanie Avalon: I'm starting to think this might be like a four-part episode. It'll be like the AMA month. It'll be like January, the AMA month. [laughs] Okay, so, David, "Have either of you taken a DNA stool analysis for parasites?"

Cynthia Thurlow: Yes, multiple times. I have had parasites, more benign parasites, like Blastocystis, which is very common. Let me just back up and say, it is very common to see parasites even in first world countries. Don't think that, oh, you haven't traveled, there's no way you've been exposed. It's really more about exposure and susceptibility. I think that the really exciting story to share is my Morocco tales, because that's where I got the worst food poisoning of my life. I had probably an acute parasite issue that morphed into a fairly significant parasite issue and we believe is a reason why I ended up developing a ruptured appendix and being so sick and necessitated. So, let me back up further and say that you can have an acute reaction to a parasite infestation and then you can have chronic parasitic infections. I have had both and the second one was harder to tease out. 

But I'm grateful that I have amazing colleagues who, as soon as I told them my symptoms, they were like, you definitely have X. I kept saying, “No, no I've done a GI map and it didn't show it.” And I ended up going through a parasite expert who puts your stool, your poop in a slide and looks at it under a microscope. Microscopy, which is pretty important, and I indeed had two parasites, and I had Candida and I had E. coli. Within one dose of antibiotics, I felt like a different person. There was no question there was something wrong with my gut because I had tremendous bloating. By the end of the day, I looked six months' pregnant, which is a problem because there's no way I'm pregnant. I had horrible, horrible gas, like, distinctively bad foul-smelling gas, and I just didn't feel good.

It didn't matter how much I slept, what I ate. It was like as soon as I ate it started this whole bloating, gas, loose stools situation that went on for probably a month until I had gotten the stool results back. It was actually an expensive test that's done out of a lab in New Mexico, But for me, life changing. I didn't want to go on it. I literally had to take one day of one antibiotic to kill this thing. I was so grateful that I had something that could treat it. 

Melanie Avalon: Do you know what antibiotic it was? 

Cynthia Thurlow: As I am saying this. So, this is Giardia. Giardia is generally transmitted in water. If you have like, as an example, doesn't mean everyone has a well. If you are exposed to contaminated water or people that have Giardia and they don't wash their hands after they go to the bathroom, you can get exposed to it. So, I took tinidazole. It's T-I-N-I-D-A-Z-O-L-E. 

Melanie Avalon: Wow. It only took one and it knocks it out? 

Cynthia Thurlow: Yeah, it's like a large bolus of antibiotic. My husband had to be treated, too, even though we didn't test him. Parasites can be transmitted in saliva and sexually. I've done a lot of interesting international travel and this female physician friend of mine was adamant, as soon as I talked to her, she was like, I don't even need to test you, you have Giardia, but I didn't just have Giardia. I had another friend too, [laughs] so it was pretty disgusting. It was like literally one dose of medication and the next day I felt 1000% better. 

Melanie Avalon: Wow. That's crazy. 

Cynthia Thurlow: Yeah. Aren't you glad you asked it? I saw that question and I was like I will be happy to answer that question because conventional testing for ova and parasites does not always pick this up. Even the GI Map, which I clinically believe is a really really good test, never picked this up. 

Melanie Avalon: Yeah, that's one of the things. Because I've done parasite stool testing, I mean, probably multiple times. Honestly, I know some of them have been negative. I don't even remember if some of them pick something up. I just remember at one point I was working with a practitioner and it came back negative. But then he was like, “All your symptoms match parasites.” And he said most people have parasites. He had me do a course of Alinia, are you familiar with that one? 

Cynthia Thurlow: I am not personally, but only because I myself have not written a script for it.

Melanie Avalon: Okay. Yeah. He said that it was like a game-changing anti-parasite drug that revolutionized so many of his patients and it probably helped. It was during the time when I was at a really not feeling well place health wise, so I don't really know what was doing what, but I did do that. I also have done, I've talked about on the show before, have you taken Mimosa pudica? 

Cynthia Thurlow: I have not. I've taken a lot of stuff, but I've not taken that. 

Melanie Avalon: Oh, my goodness, Cynthia, and listeners, I know they've heard me talk about it before. Okay, this stuff, I should probably do another round of it. So, it doesn't kill anything. So, you don't get detox effects because it's not making anything angry. It's a very sticky gelatinous, something from some tree or something. The thing that's confusing about it and the reason I'm being so hesitant, like you can look it up, people have pictures. If you put it in water, you'll see that it forms a really long mucusy string. So, you end up passing that regardless. It's going to look like you're passing parasites regardless because it just looks like that after it comes out of you. But it will grab things and I swear to you, [laughs] the things that have come out by taking that were shocking to the point where I was like, I can't keep taking this is too scary. 

And that's the response. There are like groups dedicated to this basically, but it's super cheap. You can get on Amazon, Mimosa pudica and maybe I should make this someday. It's crazy, that's all I can say. It's crazy. 

Cynthia Thurlow: Yeah. I think what's interesting as a traditionally trained provider, it's always amazing to me that there are a lot of herbs and antimicrobials including berberine as an example. It's a potent antimicrobial that can be very effective at getting rid of pathogens and they don't have the same detrimental impact on the gut microbiome that traditional antibiotics do. Let me be clear, there was no other option for me. There was no antimicrobial that was going to kill what I had because it was so substantial and significant. I'm like, I will be forever grateful that I got some validation. But having said that, it's just nice to know that there's a lot out there that we're still learning about herbs and other potent combinations of different ingredients that can be very beneficial at killing off what does not belong. If you need antibiotics to kill off what does not belong, there is no shame in that either. 

Melanie Avalon: Yeah, and I think the thing I really want to emphasize about Mimosa is it's not killing anything. It's literally just physically grabbing stuff out of you. That's why people don't get the detox effects like I mentioned. That's why you can actually see an entire thing. It's crazy. [laughs] It's for parasites specifically. Yes, I agree 100% with what you're saying about. There are so many options and alternatives out there and it's nice that there's more and more awareness about it. Especially like with the berberine, people think about that primarily for blood sugar control. We talk about this in Episode 296 with Scott Emmens, I'll put a link to it. It was actually first used in 3000 BC, which is so long ago, and not for blood sugar control. They didn't even know that was a thing back then, but for gut inflammation and yeah, GI health, so crazy.

That actually reminds me of another question on here because I'm not saying antibiotics are bad, but they're definitely something where, there's a cost benefit and we don't want to be inundating ourselves with antibiotics 24/7, but we take them when necessary and they can be life changing like you said. Sort of in that vein, but not really because we don't really have anti-antibiotic rule. But this question is from Amy. She says, “I love the last episode where you both admitted you color your hair without shame [laughs] and not using cleaner options. I would be curious, what other things are you willing to "Bend the rules for?"”

Cynthia Thurlow: I'd probably say, like, if I go to a nice spa, there's an organic one in my area and I know what they use because we have conversations. But if someone takes me for a nice massage or I'm being treated to spa treatments, I do not micromanage what they're using on me because I will then not relax and enjoy myself. I'd probably say things that are leaning into pampering that are like gifts or they're just an experience. It's like I have to kind of readjust my expectations because if I start asking, then I'm going to be hyper focused on everything that's being used and that's actually not a lot of fun. I would probably say that is the other thing that I'm probably-- in that context, I'm probably very laid back versus what I purchase to use on my body at home. Very different. How about you? 

Melanie Avalon: That's so funny. When I go to massage or I get my nails done, I always bring my own stuff, [laughs] actually, and that's good for a question later. I used to think it would be cumbersome, but I mean, I have to be always doing my nails because of my Instagram and stuff like that. There's this one oil, I can put a link to it on Amazon. It's an MCT oil, basically, but it's a massage MCT oil, but it's just organic MCT. You can use it for everything. So, when I get a massage, I bring it with me and they don't care. When I get a manicure, it actually makes it cheaper because then I bring that and I don't have to get all the fancy upgrades and I give them that and I just let them use that for all of the lotion and everything and anything else massage oil wise. And then I got so excited because up until recently, I was having to have them use the scrubs that they have there, but over the holidays, Beautycounter came out with a limited edition scrub and a body polish.

Cynthia Thurlow: I have that. 

Melanie Avalon: Yeah, it's so good. So, for instance, if they still have that, because they tend to have it past the holidays stock up on it. I stocked up on it. So now I actually bring that-- It's one of the gift sets. Now I actually bring that with me to the nail salon as well. My other things that I bend the rules on, well, with wine at home I only drink, Dry Farm Wines. If I'm going out, I look up people know I do this, I look up every single wine and I find the organic ones and that's how I decide. I really want to make an app for this, by the way, so stay tuned. I should make that a goal for 2023 to get this app out there. If I am at a place and there's no organic wine, I will drink nonorganic wine. [laughs] 

I don't enjoy that, but I will. People know I do Emsculpt religiously. I love it. I am very concerned about the amount of radiation that it gives your body, but I think the benefits that I get from it as far as building muscle are amazing. I don't do it on my abs. People ask me that a lot, but I'm a little bit concerned about doing it right over my organs like that. So, I just do basically my extremities, my thighs, my bottom, my butt, my arms. And then this is a big one. This is a big confession. I'm probably going to be writing about this. I haven't done it yet, but I am contemplating doing Botox preventatively in my forehead. I wasn't going to, but I had a consultation and I don't know, I started really thinking about it, like, the preventative action of it and not having wrinkles down the line. So, I think what I'm going to do is because basically it's a trade-off of putting that because it is a neurotoxin. So, putting that into your body and the cost benefit, you just have to weigh the cost benefit, I think, of what matters to you or not. If I do do it, well, A, I'm going to do a ton of research. B, I really want to write a really epic blog post about this if I do it, because I think people will think if you do Botox that means that the rest of your skin care doesn't matter or that you don't value skincare. I think I want to kind of educate people on again. I need to do the research first, but if I proceed with this route, I want to maybe spread the word or awareness about the cost benefits of Botox and also why it's still super important to have really non-toxic clean skin care and why you might have both. So, we shall see.

Cynthia Thurlow: Yeah, and I think that's okay. I've always been very honest. In fact, when I was on Drew's podcast for the second time, we were talking in the context about Liver King. So, I'm sure most listeners know about Liver King and how he predominantly was focusing on this kind of paleolithic lifestyle and eating organ meats. God bless him, he eats organ meats, like, with reckless abandon. Like, it's fascinating. But as soon as I saw him, I remember saying to my son, who was like putting him up on a pedestal, I said you realize that guy is on a lot of steroids. 

Melanie Avalon: That's what everybody says. He denies it. Right? 

Cynthia Thurlow: Well, what came out recently was his steroids, like his anabolic steroid schedule and his stack of growth hormone and a bunch of other things. So, in that context-

Melanie Avalon: I missed that. 

Cynthia Thurlow: -yeah, I was saying it to Drew, I think it's important for people that are in the public eye that are influencers to be very, it's not like you have to disclose everything, but you should be honest. I think it's important for me as a middle-aged woman, in the context of our conversation, to say every year I do ProFractional, which is laser, stimulates collagen and elastin. I think that has a lot to do with why my skin looks really really good. I think some of its genetics and I think some of it's my lifestyle. And then I do Botox, I've done Botox since I was 38. I started doing Botox because I have always had a super mobile forehead and that's where it started. And I still do Botox a couple of times a year. I have done filler a few times. I've had it reversed as well.

I think a lot of if-- you chose to go that route and there's no judgment if you do. You want to work with someone that's incredibly talented. You should never look like you've had work. You should never look like your face is immobile. You should never look like your lips look, like this is just my personal opinion. You shouldn't look like you have massive lips and like crazy high cheekbones and just understanding. I think those products are designed to be used subtly, but I think if you see some people that are in Hollywood that are like the extremes, too much of any one thing is not a good thing. In the context of this conversation, I feel like I should be transparent and say that obviously a laser is pretty benign in terms of stimulating collagen and elastin. I don't per se have a problem with using Botox or fillers very discriminately because so much of the rest of my life is so incredibly healthy and balanced.

And to the person in my DMs recently who was giving me a hard time about the fact that I shared those things. Yeah, this is why people that are in, whether they're influencers, they're in the public eye, this is why people honestly don't want to share because they don't want to be criticized. But I don't care if anyone agrees or disagrees with that decision because to me it's my decision. With that being said, I think I would be doing the listeners a disservice if I didn't share that as well. 

Melanie Avalon: Well, thank you for sharing that and I am so enjoying this conversation. I have some quick thoughts and questions. One, mentioning the laser, is that the same thing as BBL? 

Cynthia Thurlow: So, I'm going to say BroadBand Light is different than the Brazilian butt lift because I very innocently last year said, “Oh, I got BBL.” And people were like, “You did?” 

Melanie Avalon: Yeah, you said that to me. I remember you were like, you said you were getting BBL. So, something about the next day and I was like, “Oh goodness, that's like an intense surgery,” because I think we still recorded a podcast maybe the next day. I was like, “How is she doing this right now.” 

Cynthia Thurlow: Yeah, this tells you how long I've been doing BBL. It was preceded the Brazilian butt lift, which I'm told is going out of favor according to my plastic surgeon friends, which is a whole separate tangential rabbit hole that we won't jump down. In conjunction with ProFractional, I do BBL and what it's doing is any brown pigmentation. I don't have a lot of hyperpigmentation in my skin. We do that preceding the ProFractional. I hate it. I hate both of them honestly. It's like a love-hate. I'm doing it in January, which is usually the month I do it. I hide for four days and then I feel fine. With that being said, the laser in and of itself is looking for the pigmentation helps dissolve it. If you have some brown pigmentation, the laser will identify it, it will help dissipate it, but it will actually get darker for a couple of days or maybe a week and then it goes away. 

For me, I think the two of those together have been super powerful. But, for anyone that's just doing BBL - BroadBand Light, it is not painless. Make sure whoever you're working with is like getting you prepared for that because it's almost like having a rubber band snapped against your skin. As you can well imagine, doing it once is not a big deal. If they're doing your whole face that can be painful. Just make sure that they're giving you either topical lidocaine or giving you something to make you feel comfortable. 

Melanie Avalon: Although caveat, also check and make sure your practitioner lets you use that because it was during the podcast last time when we were talking about I was going to go do it and then I put on numbing cream during the podcast, which apparently is some people let you. But, where I went to Ideal Image, which I'll say their name because I think they're the biggest. They're like the go-to place. They do not let you use numbing cream. So, do not use numbing cream if you're going to them.

Cynthia Thurlow: Yeah, and my practitioner, they put it on for you. Like when you arrive, you arrive an hour before your treatment and they put it on for you. With very few exceptions, I'm very comfortable with BBL. There are spots when they do ProFractional that are tender, like along your forehead line. It freaks me out when they do underneath my eyes and my nose is a little sensitive, but beyond that, not bad. Not bad at all. 

Melanie Avalon: I've heard that old therapy is the most painful thing.

Cynthia Thurlow: Morpheus is supposed to be very, very painful. I'm not ready, if someone were to give and actually the person I go to who trains providers all over the United States doesn't use those technologies yet, because she still feels like ProFractional has just as much benefits. But every time I see her, I'm like, “So what's the latest?” And then she'll kind of get me caught up.

Melanie Avalon: What's really interesting though, because you mentioned the laser, so I was talking with a friend about whether or not I should do Botox or not. It's funny because he mentioned people doing lasers and Botox and whether or not you talk about it on social media, it's interesting that for some reason, Botox, I think, has more of a stigma. I have literally no issue talking about BBL or lasers or that seems almost like biohacking in a way, but for some reason, Botox feels more fake. I don't know why because I was thinking about it more, it's not even affecting your skin, it's just paralyzing the muscle underneath so you're not wrinkling your forehead all the time and not forming those lines that last. So, I find that really interesting. I mean, I think you could make the argument that well, maybe not it's because you can make the argument that Botox is biohacking [laughs] but--

Cynthia Thurlow: I think you could and here's the thing, like, I just interviewed Dr. Amy Killen, who's a female biohacker physician, and she's so knowledgeable and offline we were having discussion about some of the things that she does. She's very transparent and that's why I hope to be just as much for listeners so they can kind of get a true sense, like some of this is genetic, some of its lifestyle, and then I get help from other things. That's what we're sharing in the context of this conversation. Amy was talking about, she does all the things, PRP, stem cell stuff. It's very interesting. There's a continuum. It's all very relative. To some people, Botox may be like taboo and then others are like, "I'll do everything up to surgery." Some people are like, "I want to do everything up to surgery and surgery," and there's no judgment provided that you can afford it and you're not body dysmorphic. I think that everyone has to decide what they're comfortable with and what makes sense. From my perspective, I just wanted to add that caveat that I think I want to be fully transparent as a 51-year-old female that I try to do as many things as I can to feel as good as I look internally and reflect that externally as well.

Melanie Avalon: Yeah, I could not agree more. And then when I was talking to that friend, I said, I was like, “Well, it's a neurotoxin.” He was like, “Well, wine is a neurotoxin.” I was like good point [laughs] or alcohol. Yeah, no, I agree with the perspective and what's important to you and no judgment and just do you.

Cynthia Thurlow: I think it's just a healthier space to exist, and I don't have the emotional bandwidth to sit around and be judgy of other people's choices. It's like as long as you're not hurting anyone, there's very few absolutes where I'm okay, that's not a good decision. If you're harming yourself, a child, an animal, other humans, that's not good. Beyond that, it's like, I just don't have the bandwidth to worry about what everyone else is doing. It's like, if it works for you, that's great. If it doesn't, then course correct. 

Melanie Avalon: Also, one last thing to that point and I mentioned this earlier, but it's like, oh, if you're getting Botox, people might think you're lying about the importance of safe skin care or antiaging skin care. But, if you think about it, they're all really important. Like doing a process where you're paralyzing the muscle and keeping wrinkles from forming from just the mechanics of your skin doesn't negate the super overwhelming importance of taking care of your skin. Like, you would still need to do both.

Cynthia Thurlow: I take AG1 several times a week after working out and when I’m ready to break my fast and it really makes me feel unstoppable. I love to add it to a protein smoothie or actually will drink it with filtered water and I love both variations. My 17-year-old also enjoys AG1 after a workout to ensure he stays really well hydrated. A great deal of what I focus on in my personal life is ongoing gut health improvement. I do feel fundamentally that AG1 has contributed significantly to improvements in my gut health over the last three years. I feel as if the key health benefits from multivitamins, minerals, pre and postbiotics all work together synergistically to improve my gut microbiome. AG1 is way more than just greens. It’s important to note that it’s made with 75 super high-quality vitamins, minerals, and whole food source ingredients that deliver incredible benefits to the gut microbiome, as well as sleep support, assistance with energy, and so much more.

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Melanie Avalon: Damon wanted to know, laser hair removal, is it worth it?

Cynthia Thurlow: Oh my God, yes. Oh my God, yes. It's funny. You do laser therapy and then you realize in your 40s into your early 50s, you don't have as much body hair. So, I'm like, what was I thinking. I went gangbusters in my 30s. Yes, yes, yes.

Melanie Avalon: I agree. I don't think I commented on barely any of the comments in the thread. But when I saw this one, all I did was I wrote yes, all caps.

Cynthia Thurlow: Yeah, well, think about it. People spend years doing bikini waxes and electrolysis.

Melanie Avalon: And think about forgetting to shave your underarms or your legs. You don't have to anymore.

Cynthia Thurlow: Yeah, although it's funny, I did my legs and my bikini area and I guess I took too well to it because I bought a package. They were like, literally “You've done so well. What else can we do? What else can we do for you?” For me, it was like life changing because I had done like, bikini waxes every month forever and eternity, and then all of a sudden I was like, this is great. 

Melanie Avalon: It's funny because when they try to sell you stuff and they're like, “This will be the best thing ever,” and you're like, “But really?” No, it really is. [laughs] 

Cynthia Thurlow: No, it's resounding. It is worth every penny, every single penny. 

Melanie Avalon: Yeah. I've done the Brazilian, the arms, the legs. Now I'm doing the upper lip. I think that's everything. [laughs] There's nothing left.

Cynthia Thurlow: I had blonde hair on my face. I've been just doing dermaplaning because to me and it's like, here's a fun topic for conversation. During the pandemic, when I could not get to get threaded or dermaplaning or anything, my anesthetician had recommended something called Tinkle, T-I-N-K-L-E. You can find it on Amazon. It's like really inexpensive and it's a little like razor for women, so you can get rid of fuzz on your face. Oh my God life changing. I literally was like, what was I spending all this money on threading for, for years [laughs] and then waxing before that. I was like, “Oh my God.” 

Melanie Avalon: Is it special or is it just a little razor? 

Cynthia Thurlow: Yeah, so it's for your face and it's not as strong as what a man would use. To me, it's like I can use it in between facials. And it's amazing, just amazing. For all those little weird hairs, if you like mind just tweeze them. I'm like, “Oh my God, this is amazing.” So highly recommend.

Melanie Avalon: They always have these at Marshalls and TJ Maxx. Maybe not that brand, but I use those or I used to. Oh no, I still do because I'm still doing the upper lip. Okay, here's back to non-skincare health, beauty-related things. What are your top three book recommendations besides your own?

Cynthia Thurlow: Okay, I've given this a lot of thought, I would say the books that are really in terms of health and wellness, I'm going to just leave it there because there're so many books. I would say the books that really shifted my perspective on a lot of different things, XX Brain by Dr. Lisa Mosconi, who I've been trying to interview for a year. She's like knee deep in research. She works at Cornell. That book helped me solidify why women-- and this is my opinion why women can benefit from hormone replacement therapy.

I would say the other book that I found really helpful, like in that space is Why Estrogen Matters by Dr. Avrum Bluming and Carol Tavris. I have had him on the podcast. We will link that in the show notes. The Women's Health Initiative is probably the most detrimental study that's ever been conducted on women in terms of the net impact on practitioners prescribing hormones and women taking hormones. You have a whole generation of clinicians and women who are fearful to take and/or prescribe medications. 

I would say, most recently, a book that really has had what I would say is this book, is the book I can read now because I've done the work. The Myth of Normal by Dr. Gabor Mate and that podcast will be out with him on December 24th. So, talking about the role of trauma in your life, I mean, he's changing the narrative for the way that we view trauma and doing it in a way that is through the lens of compassion and as someone that's a survivor of childhood trauma, both physical and emotional. For me, that book just allowed me to view my parents from a very compassionate lens. I would say those books right now in terms of health and wellness are the books that I probably recommend the most. For full disclosure, they're not easy-breezy reads. Lisa Mosconi's book, I think, is one that I recommend quite a bit to patients and clients that is more accessible. Myth of Normal is excellent, it's long and I would say that Why Estrogen Matters is a good read as well. How about you? 

Melanie Avalon: That's really awesome recommendations. So, I think my favorite is Lifespan. Oh, wait. No, I'm torn. Well, okay. So, Lifespan, David Sinclair's book, Why We Age and Why We Don't Have To. It's basically just everything I'm obsessed with. And what I love, when I interviewed him on the show, I might have told you this. Did you know he drew all of the characters in the back? 

Cynthia Thurlow: Really? So talented. 

Melanie Avalon: Yeah. He said that because in the very back there's hand drawn pictures of the people and everything. He drew all of those. He said he drew them because he wanted to put the actual pictures or whatever, but they couldn't get the rights to everything. So, he's like, “I'll just draw it.” [laughs] Isn't that crazy? 

Cynthia Thurlow: Well, that's along the lines of, like, when I'm in awe of people that are doing something artistic on a stage in the performing arts, okay, there's another level to my respect for him. 

Melanie Avalon: Yeah, no, it's insane. And if so you listen to my, that was the first interview I had with him. If you listen to it, he tells me this in real time, and I'm just, like, in shock, in shock. I'll probably say, this is so hard. You know what I haven't read The Paleo Solution since I read it in, like, 2012. But that's what changed my life. Like, that's the reason I'm doing what I'm doing today. Robb Wolf's book, I think I will have to include that I'm torn between James Nestor's Breath and I think I might have to do Kelly McGonigal's The Upside of Stress just because that book-- I need to try to get her on the show. That book was so valuable for me because I started stressing so much about stress, which, yes, stress has a lot of negative health effects. That's no surprise. It's not really negotiable. There's this whole aspect to it where perception affects how stress affects you. And so, reading that book took the biggest weight off of my shoulders about stress and how you can reframe your experience of stress and use it to your benefit rather than as a detriment. 

Cynthia Thurlow: I love that. It's someone said to me years ago, trying to pick your favorite book is like trying to pick your favorite child, it's impossible. Where I sit, where my desk is in my study, I literally have the ability to see hundreds of books. It's so hard because there're so many great books that I've read, but it's impossible to have a favorite. Just for listeners to understand, those are the three that have had the most impact on me. They've just completely blown my mind. Obviously, the ones that Melanie is identifying, two out of three I've already read. But I'm always reading. Just like, Melanie, I've actually got Sally Norton's new book on my floor to read, I'm like after I get done with podcast prep for this week. 

Melanie Avalon: I feel so bad because I always get her confused with Susan Owens because they both talk about oxalates a lot. I've had her on the show.

Cynthia Thurlow: Yeah, this will be my first time. I've had one other oxalate expert who I think is trained with her, but her book is coming out. So, I was like, it's probably time to revisit the oxalate issue. 

Melanie Avalon: That's awesome. I didn't realize she had a new book coming out. 

Cynthia Thurlow: Yeah, it's called Toxic Superfoods. [laughs] I'm sure there will be lots of overlap with Gundry's kind of methodologies about plant-based toxins.

Melanie Avalon: That's awesome. Awesome. Here's a quick one. This is from Danielle, "What is your favorite holiday tradition?"

Cynthia Thurlow: I think a lot of the traditions that are important for us is just a lot of togetherness, a lot of disconnection from work and social media and things like that. I would say there're a lot of things that we have done as a family including like decorating the tree, decorating the house, making cookies. When my kids were younger, they were more interested, invested in those things. But I think it's the quietness around, like Christmas Eve when we go to Mass and then we read particular Christmas books and then there's a nice meal and just savoring that time. There was a recent study that came out and it talked about how much time you spend with different people throughout your lifetime. As someone with a 17-year-old and 15-year-old, I read this study and my heart hurt. The great thing that I'm going to bring to this conversation is that it just reaffirms why it's so important to connect with one another. 

So, when I think about holidays, I just see it as connection, like spending time together, making meals together, making memories together, not per se, like one specific thing, like do we drive around and look at Christmas lights? Yes. Do we make specific kinds of meals? Yes. But what I value the most, especially now that my kids are older, is just being together, being silly, watching movies, trying to deal with all of the challenges of navigating in laws and parents and expectations for kids and everything else. How about you? Does your family have special traditions around Christmas or the holidays? 

Melanie Avalon: Well, first of all, I'm obsessed with everything Christmas, and mine was basically the same on Christmas Eve, we'd always had a tradition growing up of opening like, one present the night before and trying to make it a present that is something we could do together. Normally it's like if somebody gave somebody a game or something, and then we would do the gift and yeah, that's always been my favorite thing hands down. We are a big wine loving family. Having the Christmas wine and opening the presents and the Christmas Eve and playing the music, Trans-Siberian Orchestra, I am all about it. I love it. Actually, what we've started doing, I feel like it's been ever since everybody's been adults, it's been changing around. Now sometimes I think last year, maybe even the year before, we opened all of our presents just on Christmas Eve, the night before, because people are more, I don't know, spirited and lively in the evening than coming all over during the day.

Cynthia Thurlow: We've tried that. My kids always beg. My husband's kind of a traditionalist about the gift stuff. I think because I grew up with divorced parents, we just opened gifts. When we opened gifts, it wasn't regimented. My kids every year are like, can't we just open gifts on Christmas Eve. And my husband gets very rigid. I just always say, my husband's 90% of the time he's really easy going, and if he gets fixated one thing, I just tell the kids, back off. So, yeah, they're allowed to open one gift on Christmas Eve and then the rest on Christmas. 

Melanie Avalon: Yeah. We didn't start doing this until very recently, and we're all very much adults now, but growing up like your kids' age, we never did more than one the night before. I don't think we even wanted to. My dad is that way with Monopoly, because Monopoly is always the game we would always play, and we'd always want to do things like play how there's, like, 50 million spin offs of Monopoly, like, all the different themes? No, he, like, only wants to play the original. We would always have debates about, like, the rules and because there's a lot of, I think, like, little fun things you can add or change the rules little bit, nope. [laughs] It had to be the traditional way in the rule book. 

Cynthia Thurlow: I'm married to an engineer, so I'll just leave that there. Anyone that's married to engineers, know engineers, you understand they can be a little rigid sometimes, but I give him a lot of credit because he's usually pretty laid back about a lot of other things. 

Melanie Avalon: So funny. Two last quick ones. So, one is sort of health related. Leslie says, “I work at HOTWORX, 24 hours Infrared Fitness Studio. What do you think about a 3D workout heat exercise infrared sauna?” 

Cynthia Thurlow: Okay, I know exactly what HOTWORX is and I love the idea. I'm going to come at this from two lenses. So, number one, I hate being hot, really hot when I'm exercising. Hate it. Like warm yoga, good. Ashtanga yoga, that's at 105 degrees. No, don't enjoy it at all. For me personally that would be a no, because I just don't enjoy being really hot unless it's hot because I'm exercising at a level that I'm increasing my basal metabolic rate and my internal thermostat.

Number two, I think the concept of a 3D workout sounds great. I think it's probably highly bio individual. If you are a 25-year-old woman who is really lean and you're pushing yourself all the time, and you're not getting a menstrual cycle and you're overdoing it, I kind of call it the triad of over fasting, over exercising, over restricting. 

But I think for probably the average person, it's probably, like, a fun way to exercise. We have to think about what heat and exercise are. They're forms of hormesis. It's the right amount of stress at the right time. I think that it's important to recognize where are you in your cycle, how is your sleep, what's your stress like. Like, it's just adding additional stressors to your body. I think in the context of someone who's sleeping well, who's in the follicular phase of their menstrual cycle, who doesn't have too much stress, that's not overdoing it and is staying hydrated, it's probably fun. That would be my guess. 

Melanie Avalon: That was basically my answer, was that I think it could be really great like, it can be a great way of hacking and getting more bang for your buck as far as benefits go. But you also need to know yourself. I'm literally just spitting out what you just said. You have to know yourself and some people it's going to be too much and it's going to be overdoing it and it's not going to have the beneficial effects in the long term because it's not allowing the adequate recovery in between. And if it's fitting into an overly stressful lifestyle anyway, it might not be the way to go. I think you really just have to know yourself. I haven't done HOTWORKX. 

Cynthia Thurlow: Yeah. no offense to anyone who loves working out in a super hot environment. I hate it. I've been that way my whole life. Hate it with a capital H. For me, like if I went to the gym and it was cold in the gym, good. If I walk outside and it's kind of hot and humid, not as interested in walking as long. But it's not that I don't see the utility I just personally hate being that hot. I hate it, just despise it. The only thing I can compare it to is like, being in Morocco, which was like an oven. [laughs] We're telling my husband I don't think we'll ever come back because it was just so hot. 

Melanie Avalon: I'm the same besides my sauna sessions where the purpose is being hot and it's relaxing, especially with infrared, not getting that hot. But I'm not about the heat. I'm all about the cold. are you guys getting a crazy cold front because it's getting down next week to 10 degrees. It doesn't get 10 degrees here. 

Cynthia Thurlow: Yeah. Atlanta is going to be in a kerfuffle. Yeah. For me, it's like when I walked my dogs this morning, it was 30 degrees and it's like perfect for them. I put a hat on, I've got a light jacket on and I'm totally happy. 

Melanie Avalon: I'm so pumped. Especially because the last few years has been warm on Christmas, it's going to be like 15 degrees. I am all about it. This is going to be great. 

Cynthia Thurlow: Yeah. I just feel like Christmas should be cold. We had, gosh it was probably ten years ago, we got snow in Virginia on Christmas Eve and it was like a dusting, but that's still like in Northern Virginia that's a shutdown mode. Everyone's freaking out. I was like, this is completely appropriate.

Melanie Avalon: I'm just worried about ever since that Texas, was it Austin or wherever when it got really cold and didn't it mess up all of the water, like the pipes and everything. I'm like, please, that cannot happen. [laughs] I need my toilet.

Cynthia Thurlow: Well, you know what they always say. I lived in a neighborhood in Northern Virginia and most of the homes were new construction when people bought them and the builder knucklehead that they were a lot of exterior pipes were freezing during really cold spells. If you're ever concerned about your water freezing in a pipe. You can always keep your water like a little drip just to kind of keep things moving. Yeah, lots of experience with friends who went through that. Not fun. Not fun at all. 

Melanie Avalon: Yeah, they always post-- when it starts getting cold they post signs everywhere saying, “Freeze warning and let your faucets drip.” Okay, well, this was fun. This is definitely going to be a two-parter. I'm thinking it's probably going to be a three-parter, maybe a four-parter. 

In any case, for listeners, if they would like to submit their own questions for the show and if this is your first episode listening, which since we get so many listeners, it probably is somebody's first episode listening, welcome to that person. Normally we talk about Intermittent Fasting a little bit more. You can submit your own questions to questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. These show notes will be @ifpodcast.com/episode300. Those show notes will have a full transcript as well as links to everything that we talked about. So, definitely check that out and you can follow us on Instagram. We are @ifpodcast. I am @melanieavalon. Cynthia is @cynthia_thurlow_. I think that is all the things. Well, this is been really, really fun, Cynthia. Anything from you, before we go?

Cynthia Thurlow: No, I'm looking forward to round number two.

Melanie Avalon: All right, sounds good. I will talk to you next week. 

Cynthia Thurlow: Sounds good. 

Melanie Avalon: Bye. 

Thank you so much for listening to the Intermittent Fasting Podcast. Please remember everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week. 

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Jan 01

Episode 298: Clean Hair Products, Skipping Meals & Mortality, Dietary Recall Studies, Defining OMAD, Breaking Fast Easily, Satiety, And More!

Intermittent Fasting

Welcome to Episode 298 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

BUTCHERBOX: Grass-Fed Beef, Organic Chicken, Heritage Pork, Wild-Caught Seafood: Nutrient-Rich, Raised Sustainably The Way Nature Intended, And Shipped Straight To Your Door! For A Limited Time Go To butcherbox.com/ifpodcast And Get The New Year Bundle For Free Plus $10 Off When You Sign Up Today. That’s A 14 Oz Pork Tenderloin, 2 Lbs Of Ground Turkey, And 4 Top Sirloin Steaks Free In Your First Box!

ATHLETIC GREENS: 75 High-Quality Vitamins, Minerals, Whole-Food Sourced Ingredients, Probiotics, And Adaptogens In One Delicious Scoop! Get A FREE 1 Year Supply Of Immune-Supporting Vitamin D AND 5 FREE Travel Packs With Your First Purchase At athleticgreens.com/ifpodcast.

 JOOVV: Like intermittent fasting, red light therapy can benefit the body on so many levels! It literally works on the mitochondrial level to help your cells generate more energy! Red light can help you burn fat (including targeted fat burning and stubborn fat!), contour your body, reduce fine lines and wrinkles, produce collagen for epic skin, support muscle recovery, reduce joint pain and inflammation, combat fatigue, help you sleep better, improve mood, and so much more!! These devices are literally LIFE CHANGING!! For A Limited Time Go To Joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount!

To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get The New Year Bundle For Free Plus $10 Off When You Sign Up Today. That’s A 14 Oz Pork Tenderloin, 2 Lbs Of Ground Turkey, And 4 Top Sirloin Steaks Free In Your First Box!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

The Melanie Avalon Biohacking Podcast Episode #110 - Jon Levy

Ep. 160 – The Power Of Behavior-Centric Health & Wellness: Trade-Offs for a Long and Happy Life with Jon Levy

ATHLETIC GREENS: Get A FREE 1 Year Supply Of Immune-Supporting Vitamin D AND 5 FREE Travel Packs With Your First Purchase At athleticgreens.com/ifpodcast.

Listener Feedback: Diane - Better hair products

KNOW YOUR ENVIRONMENT. PROTECT YOUR HEALTH. EWG.

Episode 294: Creatine, Excess Skin, Toning Up, Clean Hair Dye, Hormones, Caffeine, Cortisol, Hormetic Stress, Jet Lag, Hydration, Melatonin, And More!

Listener Q&A: Cara - New study found increase risk of early mortality with fasting?

Meal Skipping and Shorter Meal Intervals Are Associated with Increased Risk of All-Cause and Cardiovascular Disease Mortality among US Adults

JOOVV: For A Limited Time Go To joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount!

Listener Q&A: Kemla - Does it matter?

Episode 116: The Great OMAD Debate

Listener Q&A: Nancy - one meal a day?

Listener Q&A: Spencer - Breaking fast

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 298 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting and Wine. I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time and get ready for The Intermittent Fasting Podcast.

Hi friends, I'm about to tell you how you can get a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, plus $10 off. Yes, all of that incredible meat, plus $10 off, all for free. We are a bit obsessed with a company called ButcherBox, which is always in season. Some of my favorite meals that I had throughout the holiday season were fantastic meat and seafood from ButcherBox. Now with the new year, it is time to celebrate with only the very best of the best when it comes to meat and seafood that you put in your body, as well as meat and seafood that helps support our planet and the environment.

They make it so, so easy to get high-quality humanely raised meat that you can trust. They deliver 100% grass-fed, grass-finished beef, free-range organic chicken, heritage-breed pork that’s really hard to find, by the way, and wild-caught sustainable and responsible seafood shipped directly to your door. When you become a member, you’re joining a community focused on doing what’s better for everyone. That includes caring about the lives of animals, the livelihoods of farmers, treating our planet with respect, and enjoying deliciously better meals together. I did so much research on ButcherBox, you can actually check out my blog post all about it at melanieavalon.com/butcherbox.

All of their beef is 100% grass-fed and grass-finished and they work personally with all the farmers to truly support the regenerative agriculture system. I also did an interview with Robb Wolf on my show, The Melanie Avalon Biohacking Podcast, all about the massive importance of supporting regenerative agriculture for the sustainability of not only ourselves but the planet. This is so important to me. I’ll put a link to that in the show notes. The value is incredible. The average cost is actually less than $6 per meal and it's so easy. Everything ships directly to your door and it is so delicious. I love carpaccio for example. The ButcherBox steaks are incredible for that. That's how you know it's good steak when you can eat it rare like that and ButcherBox has an incredible offer for our audience.

You can get the New Year bundle for free, plus $10 off when you sign up today. That's a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, in your first box. Sign up @butcherbox.com/ifpodcast and use code IFPODCAST to claim this offer. Again, to get a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, plus $10 off, sign up @butcherbox.com/ifpodcast and use code IFPODCAST to claim this offer. We'll put all this information in the show notes.

One more thing before we jump in, are you fasting clean inside and out? So, when it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting. It's actually our skincare and makeup. So, as it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disruptors, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. 

And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies, when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking. And the effects last for years. 

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies and so much more. 

You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my Clean Beauty email list. That’s at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list, so definitely check it out. You can join me in my Facebook group Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you’re thinking of making Clean Beauty and Safe Skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It’s sort of like Amazon Prime for Clean Beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. And we’ll put all this information in the show notes. All right, now back to the show.

Hi everybody and welcome. This is Episode number 298 of The Intermittent Fasting Podcast. I’m Melanie Avalon and I’m here with Cynthia Thurlow.

Cynthia Thurlow: Hi, Melanie.

Melanie Avalon: Hi, Cynthia. Can I tell you a story and also ask you a question? They're unrelated.

Cynthia Thurlow: Of course.

Melanie Avalon: Okay, great. [chuckles] This week I had a really crazy moment. I had two interviews for press-related stuff, and I was prepping for one of the interviews. You might have seen this on my story, so I'm sorry if I'm telling the story again. I was prepping for one of the interviews and I knew one of the questions was going to be about being a female entrepreneur. So, I googled, well in DuckDuckGo but it happened in Google too. I checked. In DuckDuckGo, I googled “tips female entrepreneur” the first hit, literally the first hit was an article from Forbes, and it was the one I was in. And not only was it the first hit, but the preview text was my part of the article. So, I literally googled something to prep for the next day and I was the first hit. Isn't that crazy. I keep thinking about that. That's very surreal. Like, out of all the people in the world. 

Cynthia Thurlow: Yeah, that's amazing. 

Melanie Avalon: So, I thought it was funny that I was trying to find the answer and I clearly already had the answer. Yeah, that was my fun story. And then I have a question, but do you have any fun stories you would like to share? I know you saw Hamilton.

Cynthia Thurlow: I did. We were in New York City this past weekend, so my family and I, it's the first time we've all been together in New York in five years, which is hard to believe and it's very different with preteens versus teenagers. We had a lot of fun and Hamilton was worth every effort at seeing it on Broadway. I'm just phenomenal. The irony is I flew back to New York two days later for the Influencers Dinner. 

Melanie Avalon: All right, with John. 

Cynthia Thurlow: Yeah. Which I did last night, which was amazing. I met such amazing human beings and people that were in different fields. The irony is the only person who guessed.

Melanie Avalon: Who all were there? 

Cynthia Thurlow: There were artists, there were chief marketing officers for major brands, like recognizable brands. There was a cardiologist who was in the midst of the pandemic, like, hitting New York City, who was absolutely brilliant. People just in different fields, but all really interesting like, there was a guy who had been a record producer for, like, Biggie and Pink, just such a diverse group of people, but no egos. Everyone was lovely and you were not allowed to give your last name or what you did. So, we were all interacting and then went about putting a meal together and then sat and had a meal. We went around the table trying to guess what everyone did. 

The person who guessed correctly, what I did turned out to be the cardiologist, even though we had not even talked about any of these things. He was just such a cool person. I would never have guessed he was a cardiologist because of his personality. He was just kind of more free spirited and relaxed and not nearly as intense as most of the other people. I had an amazing evening, but I was up really late for me and then was up at 04:00 in the morning and I'm working on a solid, like, 4 hours of sleep. So, I'm sure tonight I will crash. But right now, I'm running on adrenal and it was an incredible experience. I told John that you said, “Hello.” 

Melanie Avalon: That makes me so happy. I love hearing about those events. I really want to go to one as well. John keeps sending me all the dates. I'm like, “I'm going to come to one, I promise.” 

Cynthia Thurlow: Yes, it was a lot of fun. I guess the thing that was really interesting was one of the we thought was participants turned out to be his mom, who was so lovely. I got to meet her and she was visiting from Israel. It's interesting when you see people in their natural habitat because this was actually a dinner at John's house. He was totally gracious and very supportive. I went home with a signed copy of his most recent book. His dad was this incredible artist and went home with a book of his father. So, it was like, all in all, just a really incredible, like less than 24-hour experience. Yeah, no more New York travel for a while. 

Melanie Avalon: That is amazing. John and I have been bouncing off ideas. I don't know if we're going to do this. We've been thinking we should start a podcast or something just because we talk about all of these crazy, random topics. He's so well connected. I just feel like there's a lot that we could do. [chuckles] So that's so exciting. Wow. Yay.

Cynthia Thurlow: Yeah. It was a really great experience. 

Melanie Avalon: Well, for listeners, we'll put links in the show notes. Cynthia and I both had John on our shows, so we will put links to the episodes that we had with him. His book you're invited is super cool. It's all about how well, I think the subtitle is something about the art of cultivating influence. But it's about how people cultivate influence. It's about how people become, like, respected leaders with communities and basically leaders of groups and things like that. It's really interesting. It's human psychology. So why people do what they do. So, yeah. 

Cynthia Thurlow: What was really interesting was that only a few people in the room knew who he was, but they still came to this dinner, which I thought was so cool because someone said to me, like, “How do John?” I said, “Oh, well, through my friend Melanie, but I've also had him on my podcast.” He made sure that he was like, if you ever need any support in your business or you have questions, I'm here for you. I think it's a really phenomenal way to network with people because you're so disarmed, because you're not allowed to lean into what's easy, meaning, like talking about your work or leading with your title, whatever it is that however people lead. That's not the way that I am. When you're making a meal with people, you really just get very relaxed, invested in the process. And so, we even helped clean up. We even did dishes. Everyone was part of making the meal, cleaning up for the meal. It was a really delightful evening. 

Melanie Avalon: That's so fun. It's nice for him, too, not to have to do dishes at the end [chuckles] of all these dinners because he has a lot of them and he does them in LA, San Francisco, and New York. 

Cynthia Thurlow: Well and I think it's just nice to feel like this is really the first time I've been in New York. Maybe in September when I was there, when I spoke, but this is the first time I've been back in New York where it's felt like the New York I remember. There's still a lot of mask-wearing, that's a whole tangential conversation and there's no judgment. I'm just saying observationally. There was a lot of mask-wearing and people just being conscientious, but people just seemed, like, happy to be back interacting in person in real life with other humans. 

Melanie Avalon: Yeah, that's awesome. I should probably say his last name is John Levy. I don't think I said that. 

Cynthia Thurlow: He's so smart. He was even talking about his siblings, all of whom are incredibly accomplished, too. When we found out his mom was at the table, I was like, “Oh my gosh, this is so amazing.” 

Melanie Avalon: That's so cool. Yeah, I love that. My question for you, because this episode airs January 2nd, so this will be the day after New Year's Eve or the day after New Year's Day. Cynthia, do you make New Year's resolutions and do you recommend that people do?

Cynthia Thurlow: I think that I personally don't per se change a lot from year to year. I'm of course open to the possibility, but I try to have a word of the year. That's what I lean into. In some years balance or dedication or whatever I'm leaning into and so, I'm mulling over the idea of what is going to be my focus for 2023. On a lot of different levels, I think it's probably going to be clarity about where I am in my business and where I am in my personal life. So, I do think it's a good idea to evaluate behaviors, what works, what doesn't work. But to me, I don't like to think of it as like a New Year's resolution because that to me, really means a temporary thing, whereas if I have a focus for the year, that's how I choose to frame it so that it's something I'm going to be consistently working on month to month, day to day. And so, clarity is my 2023 word, I'm fairly certain. How about you?

Melanie Avalon: That is super cool. I like that. That's a very practical, implementable thing that people could do. Maybe I should do that. I don't really and I think it's because I kind of feel like every day is like a New Year's resolution day. Like constantly, I’ve so many dreams and goals, and I always feel very inspired and motivated to be doing them. So, it doesn't feel like, “Oh, this is the chance to start anew.” I'm constantly in that vibe. Not to say that people who make.

Cynthia Thurlow: Growth headspace.

Melanie Avalon: Yeah, but I don't mean by that people who make New Year's resolutions aren't that way. It's just it doesn't feel like a milestone in my personal life right now. It might change. I'd be really curious though, if people want to tell us their New Year's resolutions. I wonder if the most common New Year's resolutions like what they are. Like the top 10. I would bet one of them is weight loss, but I bet one's probably career related.

Cynthia Thurlow: So, I am fully adulting now and between our financial advisor, our financial planner, my CPA in my business, it's like we've gotten very granular. I think part of the clarity piece for me, just for full transparency, is that we've gotten really, really, really specific in my business about where my energies go, where they do not. I'll give you an example as I'm sure it happens to you. You get asked a lot to do press, you get asked a lot to do guest podcasts. I was finding that I was spending so much time supporting other people's podcasts that I wasn't creating the space for me to be able to be in my business and not be stressed going from one thing to another. One of the rules that I created with my team was that I only do two guest podcasts a month and I could easily do 20.

It's one of those things where we've gotten very specific about what metrics, what's their audience like, is it a good fit. That's made me very happy because coming off of the book launch, this year has been wonderful but exhausting and it's not a pace I want to keep up. This is not to suggest my podcast is going anywhere or this podcast is going anywhere. I'm just talking about guest podcasting and is it in my best interest to be overcommitting myself. So, as an example, we've already filled the two spots in December, we filled the two in January, now we're working on February. That has allowed me to feel like I have a little bit more breathing space and so we're doing things like that because that serves my higher purpose. Then I can devote more time to my business and not feel super stressed, which has been my baseline this whole year for sure. 

Melanie Avalon: Yeah, no. I think that's amazing and that's something I've been really working on as well, is you want to just say yes to everything, but you can't. You need to know [chuckles] when to say no and that's okay. 

Cynthia Thurlow: Yeah, well, and it's interesting, when you really start getting granular about metrics and who is their audience, is it really serving my best interest and their own to have me on. We've had to politely say no to a lot of opportunities because I either don't want to be traveling all the time, that's another thing. Getting very clear about what speaking events I'm going to do and what are the things that are going to lead to more opportunities and understanding that, you and I both know this that our time is valuable as is everyone's. but does it serve me to be on planes and flying all over if it's really not laser focused on what I'm working towards. That's the one thing I would say, “Clarity.”

Melanie Avalon: Yeah, I think that's great. 

Cynthia Thurlow: I take AG1 several times a week after working out and when I'm ready to break my fast and it really makes me feel unstoppable. I love to add it to a protein smoothie, or actually we'll drink it with filtered water and I love both variations. My 17-year-old also enjoys AG1 after a workout to ensure he stays really well hydrated. A great deal of what I focus on in my personal life is ongoing gut health improvement. I do feel fundamentally that AG1 has contributed significantly to improvements in my gut health over the last three years. I feel as if the key health benefits from multivitamins, minerals, pre and postbiotics all work together synergistically to improve my gut microbiome. AG1 is way more than just greens. It's important to note that it's made with 75 super high-quality vitamins, minerals, and whole food source ingredients that deliver incredible benefits to the gut microbiome, as well as sleep support, assistance with energy, and so much more.

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Melanie Avalon: All ready. Shall we jump into everything for today? 

Cynthia Thurlow: Absolutely. 

Melanie Avalon: So, to start things off, this is actually some feedback from a listener. We recently were discussing toxic hair products and whether or not there were options for coloring your hair and we provided some brands. We just got some quick feedback from Diane, and the subject is “Better Hair Products.” And she says, “Hi there, just wanted to remind folks about the EWG website. Listening to your last podcast, someone asked about less toxic hair color/care. I've been looking for a while, and I found a few cheaper brands of hair shampoos and conditioners as I like to switch them often. Herbal Essence has some that rated low. Obviously, the scented ones rate a bit higher. Unscented castile soap is a one." I'm just going to insert something. This is Melanie talking. I am obsessed with unscented castile soap. I use it for everything. Do you use it, Cynthia? 

Cynthia Thurlow: I do. 

Melanie Avalon: I use it in the shower to take my makeup off and the sink to wash my hands. I mean, that stuff is just amazing. 

Cynthia Thurlow: And it lasts a while. 

Melanie Avalon: Yeah, it does. Yeah, it's incredible. I think you can also use it for the dishwasher and clothes if you make certain concoctions, but I haven't done that. She says, “I'm sure there are more, but I can't get into my personal list on the EWG website, I also found a pump hairspray that smells edible. It's raspberry and reminds me of one from the 80s that I used to use, but this is much friendlier and far less toxic. It's made by All-Nutrient, which is local to me, but I see they sell it on Amazon. I also tried a brand called I think it's Qet and the sample they sent, but it was the size of a paperclip and despite my toddler-sized hands, I couldn't even spray the thing. As far as color and lighting, I'm with you. I asked my three hairdresser friends to research this and find the least toxic/gentlest kinds, but no luck yet. Love listening to and learning from you and Cynthia XOXOX.”

I'll just comment if listeners check out that other episode. We did list quite a few dye brands that were options and I would actually love if people do have experience with nontoxic hair dye. I would love to hear if people have found brands that they like, because it's definitely one of the areas where there doesn't seem to be a lot of options. I'm surprised we didn't mention the EWG. Definitely, the EWG is amazing. 

Cynthia Thurlow: Yeah, their Skin Deep app is certainly very helpful. Diane, thank you so much for sharing those. It gives us more options to consider. Listeners, if there are other brands that you like using that are cleaner, certainly pass them along. I think to me it is a work in progress. Hair is my pain point. I'm very transparent about that, but that does not mean that there aren't wonderful options that are out there. I'm just happy I'm using Argan oil, which is super helpful for the frizz that I experience about eight months out of the year, here in very humid hot Virginia. 

Melanie Avalon: Yeah, I'm having flashbacks to growing up in Memphis and the hair situation. 

Cynthia Thurlow: I didn't realize you grew up in Memphis. I thought you grew up in Atlanta. 

Melanie Avalon: Yeah, well, I was here until 10. I was in Memphis my formative years of 10 until 17. So, middle school and high school, elementary school part of it. What's interesting is out of the entire timeline of my life, I've lived in Memphis the least. Compared to Atlanta and Los Angeles, Memphis feels like where I've lived the longest because it was when I was growing up. 

Cynthia Thurlow: So cool. Little known facts. 

Melanie Avalon: I know. Shall we go on to our next question? 

Cynthia Thurlow: Sure. This is a question from Kara and it says, “New study found to increase risk of early mortality with fasting. Please interpret.” "Hi, I saw this post on Instagram from @fastingmd. The study is referenced in the show notes. She mentions, “I love this way of life. I typically fast while I'm seeing patients because I know my brain is more clear and I am more focused. It's usually about 18 hours. I've recently tried a snack at 2:30 to take probiotics for leaky gut, but I just don't like the way I feel less on if I do have a snack. After months of trying to figure out my gut issues, I went to a functional medicine practitioner based on your advice. It was the best thing I've ever done. I had no idea how not normal my bathroom experiences were, but also the amount of mental exhaustion from worrying and trying to figure out what it was that I ate that caused the issues. I tried eliminating every food category with very little improvement. To the listeners out there who this is ringing true for, go get a specialist to guide you. I am a healthcare practitioner and I couldn't solve it on my own. I'd love to hear your opinions about the study, Kara. 

Melanie Avalon: Awesome. Well, Kara, thank you so much for your question and your experience. I will just comment with the probiotic snack thing. I don't know which probiotic you're taking, but a lot of probiotics you could take it with your meal or possibly even on an empty stomach. I would just look at your probiotic again and see if it indicates that it needs to be taken with food. But I feel like most probiotics you could take on an empty stomach, so that might be an option. Also, thank you for sharing your experience and your openness about being a healthcare practitioner and realizing that you can still benefit from a third-party perspective guiding you. That's super amazing. The study that she referenced is called Meal Skipping and Shorter Meal Intervals Are Associated with Increased Risk of All-Cause and Cardiovascular Disease Mortality among US Adults. It was published August 10, 2022 in the Journal of the Academy of Nutrition and Dietetics. 

It was a prospective study. It looked, in retrospect, at a lot of people, a total of 24,011 adults who had participated in surveys about food intake and eating behavior using 24-hour recall from 1999 to 2014. What it did was it looked at a lot of things, but one of the main things that looked at and why everybody is talking about this is it looked at the role of meal frequency and how it related to cardiovascular disease and mortality and they separated it into different options. There were people that skipped breakfast, people that skipped lunch and people that skipped dinner. They found that people who skipped breakfast had a higher cause for CBD mortality compared to those who didn't. People who skipped lunch and people who skipped dinner had a higher cause for all-cause mortality.

So, of course, it has a really scary headline, which is annoying and we can break this down. I mean, the headline makes it look like it is literally the meal skipping and the shorter meal intervals, because they also looked at how often people were eating, and they looked at that association. In the title, of course, they say that is leading to an increased risk of these diseases and death. But what did it actually find. So, what's interesting is it was looking at a lot of characteristics of people. So, it wasn't just the meal intake. The people who did not eat three meals per day, because the majority of the people so over half of the people were eating three meals per day. The people who weren't, so their general characteristics, they were more likely-- so it's a list. They're more likely to be younger men, non-Hispanic black, less education, lower family income, smokers, heavy alcohol drinkers, higher physical activity, lower total energy intake, lower diet quality, food insecure, and they snacked more. So, what's really interesting about this is [laughs] basically there was a lot of confounding factors happening in these people who were skipping meals. It's really really hard to say that it was the meal skipping that was the cause of this, when there were so many other things going on, unhealthy related habits that seemed to associate with it. 

Also, of interest of note, and I would actually be really curious, I would be super curious if this got redone now, if it would be different, because this occurred, like I said, from 1999 to 2014. Intermittent fasting has, I feel like, really become more popular probably in the last decade. Kind of near the end of the study is when intermittent fasting started becoming more popular. During the time of the study was definitely the time when we were all told that breakfast is the most healthy meal of the day. A lot of people who are skipping breakfast, especially during this time, might have had other unhealthy habits or on the flipside, people who are eating breakfast might more likely have had healthy habits. It's hard to associate causation from correlation is my point.

So, yes, the takeaway is that this was not cause and effect. This did not look at people's blood sugar levels. It did not look at an individual fasting and see what was happening in their body. It literally just looked at thousands of people what are they doing, how are they eating, and then what was their cardiovascular risk and their mortality risk. 

One last note about it, dietary recall studies can be a little bit problematic. I even heard Peter Attia say on an episode that he doesn't even ever consider dietary recall studies because we're just so bad with recalling. So, for example, in this study, from the original group of people, they removed 3136 participants due to implausible total energy intake. Meaning what those people reported didn't make sense realistically. There was really probably no way they were actually eating that. If there were 3136 people that were clearly overwhelmingly wrong in what they were saying, it makes you curious about the people that were included. So, yes, takeaways, dietary recall study issues, the timing of when this occurred during a time when fasting was not seen as a healthy practice, and then the confounding factors, I think, is huge and then lack of actual cause, and effect causation versus correlation. 

Not to say that there's not valuable information here, but those are my thoughts on this study. Cynthia, what are your thoughts? 

Cynthia Thurlow: I agree with everything that you've said. I think this is the challenge with nutritional research on a lot of levels. Patients oftentimes do not want to fully disclose what they're eating. It's not to suggest that's per se not kind of human nature, but more often than not, I know when I ask for diet recalls, sometimes I fervently believe that people tell me what they think I want to see or want to hear. Nutritional research in and of itself is challenging.

Number two, I do think that there are many issues with looking at research over a long period of time. As you very appropriately mentioned, we didn't know the insulin sensitivity of these individuals. It's my understanding from the study that it was a fairly unhealthy population that they were looking at and so, does it mean that there's more research that can be done? Absolutely.

As you appropriately stated, correlation does not mean causation and so that's why it's important. Really this is one of the challenges I have with the media is that they don't know how to properly interpret research and what they do is they like sensationalization and so, they'll throw out these articles. There's one in the New York Post that I got tagged in all over social media and people were saying, “Oh well, this is going to hasten your morbidity and mortality.” And I was like, "Hey, time out. Let's look at who sponsored the study, let's look at the data, let's look at the high quality of research.” 

We know that randomized controlled trials are the gold standard and obviously that's not what we're looking at here in this instance. I think it just really speaks to the fact we need more information, we need more research to look at this, but epidemiologic research in general looking at different types of research, nutritional research can be particularly challenging on a lot of different levels. I think it just remains to be seen. If we're looking at an already unhealthy population, it's very hard to extrapolate and then say this is applicable to everyone. Hopefully that's clear.

Melanie Avalon: Yeah. For example, what I would love for them to have done, which they could have done, I don't know, it's a little bit annoying. They could have separated it out because I mentioned all of those factors about people who were not eating three meals per day what they were more likely to be. I would be super curious if they separated out the people who were skipping a meal by any one of those confounding factors to see if there's a difference. Maybe since its food related, they could have done it by the food stuff. They could have split it by lower diet quality and food insecurity and seen if you separate it that way, do you still see that pattern. You could filter the data a lot of different ways and I bet you would have seen a lot of different things. So, it is what it is. 

Cynthia Thurlow: It's just the beginning point to really look at things. The other piece is that probably our listeners and ourselves, we don't eat a Standard American Diet and we recognize now how inflammatory and problematic the Standard American Diet is because it's highly processed, hyper palatable, too many carbohydrates, too many wrong types of fats, too little protein, and that doesn't help metabolic health at all. There're so many different things that usually when I'm looking at these kinds of articles, I always want to know like, what were they eating because I think that has a large impact on the results that they are reporting. 

Melanie Avalon: Yeah, it was interesting. I was actually thinking about that when I was reading the article because for diet quality, they actually broke down how they determined that, but they didn't give specifics. It was basically like-- It was like a dozen categories of components of food like fruits, vegetables, fatty acids. It was like a dozen of them, salt, sodium. Even within that, there's so much debate about diet. So, I find it interesting that even ranking things by diet quality, I mean, there would be nuance and debate within that. One other little note I did want to point out, I looked at the original post that she referenced on Instagram. I thought this was interesting. Do you know the @fastingmd, she follows you? 

Cynthia Thurlow: I do. I do. I think she's a fan of circadian fasting. That's kind of her cornerstone. 

Melanie Avalon: Okay, okay, got you. So, I don't know if she did this on purpose. I'll just assume she did not. It was a good moment that I thought was a good thing to draw attention to because this goes back to like really encouraging listeners to look at the source material, especially with things like this, where it gets into social media and the news. This is a very small thing, but I still think it's telling of what is happening all the time. So, for example, she mentioned what I mentioned about how the participants who are skipping meals were more likely to be all of these other factors which are mostly unfavorable in that they are associated with lesser health outcomes.

She listed the entire list, but she left out one which was the positive one. She left out higher physical activity and so it could have been an accident. I'm not saying it was on purpose, but I think it's a really good example, because I read it and I was like, wait, but higher physical activity was also one of the things on there. I think it's a good example of even when somebody says, even me right now saying, “What's in the study,” go read the original study. Because I think every time you hear not from the actual source material, you're getting a filtered biased version of it from me, from everybody, even from you. When you read it, you're going to give it your own filter and bias. The most unbiased version you can get is probably reading the original one. 

Cynthia Thurlow: I think that's important. I mean, we're realistic, I may not be able to read every single piece of research that's out there, but certainly the ones that are intriguing and really relevant. Looking at the sample size, I mean, just looking at basic tenets of the research that was done, I think can be very helpful. I have to believe if @fastingmd is anything like my team, sometimes they're so quick to get content up but sometimes things get missed. So maybe that was unintentional. But I know that Amy's, it's Amy Shah. I know that her content tends to be surrounded around honoring circadian biology as it relates to fasting. 

Melanie Avalon: Awesome. Yeah. Again, it probably was unintentional, but it was completely separate from her. It was a moment where I realized again how important it is to go look at the original stuff if you have the time and energy and it's something that you are interested in. 

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Shall we go on to our next question? 

Cynthia Thurlow: Sure. 

Melanie Avalon: We have two questions that are sort of related, so I thought we could answer both of them. So, the first one comes from Kimla. The subject is “One meal a day: Does it matter.” And Kimla says, "I hear a lot of disagreement about what really defines one meal a day." Cynthia, I'm just laughing because I think I mentioned before you know we've had, like, the great one meal a day debate on this show, like Gin and I have debated the definition of one meal a day at length, it became a whole thing. What really defines one meal a day? [chuckles] I wonder why so many people debate this. Is it just a label that people want to place on their fasting pattern?

According to Gin, I adhere to one meal a day, but if I use Melanie's definition, then it would only be sometimes. What I do know is that I typically fast for 21 hours. My eating window varies daily based on how hungry I am. Sometimes I have a five-hour window and sometimes two hours. I do use an app called LIFE on Android to track my fasting time since I've only been doing IF since June, and I always forget what time I quit eating the night before. I think I've gotten offtrack of what my question was now, basically, does it really matter if you truly eat one meal a day or is the fasting window the focus? When I start reading a lot about one meal a day or listening to all the debates over one meal a day and by the way, she's calling it OMAD. 

She says, “I start to get a little obsessed about how much I should or should not be eating during my window, and if I can have a snack or need to cluster all my food. I have noticed this tendency. So, instead I really just tried to pay attention only to how I'm feeling. This has been working great so far. I eat ice cream most nights after dinner which makes me so happy. IF is a keeper in my book. Thank you for all the information. The podcasts and resources have been great tools and I love this way of life. I have never lost weight so effortlessly, no special foods, no containers. I don't have to pack and drag food all over with me, I never feel hungry, and my crazy sugar cravings have disappeared. Thank you for clarifying this concept.”

We have another question from Nancy. The subject is “One meal a day?” and Nancy says, “I'm a new IFer and I've been doing a 16:8 fast. I read here a lot about having one meal a day during that eight-hour feeding window, which seems to contradict other things. I read or hear about eating all of one's calories within that eight-hour feeding window. I basically don't understand what it means to eat one meal within that eight-hour window. Does it mean that you can eat one meal, say at 12:30 PM, a big lunch or 07:30 PM, a big dinner and snack for the rest of your feeding window? If you do only one meal, what is the benefit of that versus spreading out your eating window within your eight-hour window? I like to have a lunch at 12:30 and a dinner at about 7:30. Is there a reason I shouldn't do that? Thanks.”

Before you jump in, Cynthia. I'll give you some recap of Gin and I's thoughts on this and what the great debate was, which in the show notes. The show notes will be at ifppodcast.com/episode298. We will put a link to the great debate, the great one meal a day debate episode that I have with Gin. It's ironic or it's interesting because Gin and I typically eat over the same amount of hours-ish, so it's typically like probably an average of a five-hour eating window, probably four to six hours. The difference is that Gin has a pattern where she has a snack and then she doesn't eat and then she eats her meal later, whereas I eat the entire time straight through [laughs] like the entire four or five hours. It's a very long drawn out pattern. Listeners probably already have it memorized. Like I eat my cucumbers and I drink my wine and then I'm cooking my food and then I eat my food, which is like my scallops, my protein, and then I eat a lot of fruit for quite a while.

Our big debate was I was saying for Gin, I was like, “Yours is like one meal a day and a snack because you're having a snack and then you're not eating and then you're eating.” I was like saying for mine that, “It's one meal because it's like being at a really long dinner where I'm constantly eating.”

Kimla's question about why does it matter, I really don't think it does. [laughs] It's more just the semantics of it. Although, that said for Nancy, I don't really know anybody who would consider like an eight-hour eating window at one meal a day. That's pretty long. So, I can share more thoughts. But Cynthia, what are your thoughts on the semantics of one meal a day? Does it matter? What do you call it? All the things. 

Cynthia Thurlow: Oh, goodness, I feel like I'm stepping into a landmine. So, Kimla and Nancy, thank you for your questions. First and foremost, I think it's important to, if you're metabolically healthy, to intuitively eat. So, when Kimla asks about some days when she has one meal versus other days she eats more than one meal, I think there's nothing wrong with that. In my estimation, one meal a day is exactly that one meal a day. When I think about Melanie's methodology and how she chooses to have like a wider feeding window, a wider eating window, I guess that's maybe the way to call it. I kind of differentiate that. I mean that to me is different. I think we can get caught up in semantics. I would say the same thing about when people ask, does this break my fast. We get nuanced and granular and everyone's stressing. I'm like, really what we should be focused on is determining how many meals do we need in our feeding window to get our protein in that's the first thing. I think that's very important for some people. If you're a unicorn and you can eat a huge meal and have 100 g of protein, more power to you. I'm not that person. I divide my food, my meals into at least two, if not three meals to get my protein in. 

Number two is I think it's important to vary what we do. I think most of us need to do that now. Do we have unicorns? Absolutely. That's a loving word when I say unicorn each one of us are individuals, each one of us needs something a little bit different based on our own needs or personal professional needs. And that's totally okay. Women that are still getting a menstrual cycle really should fast for their cycle. Women that are in perimenopause and menopause need to be careful about over fasting. I'm starting to see a lot of this women that are irrespective of life stage, but they are having very rigid rules about when they eat, how much they eat, a rigid fixation. 

I do think just one meal a day is a problem. I think it's fine every once in a while. Let me be clear what Melanie is defining as what works for her, she's getting plenty of protein in that feeding window. If you're just having one meal that has 30 g of protein, you are chronically undereating and that is something I get concerned about. There's zero judgment. Each one of us has to decide what works for our bodies. But if you're chronically undereating and you're chronically undereating protein in particular, and you are a woman north of 35 or 40, you are putting yourself at risk for metabolic inflexibility. That's what I want to just state. I recognize not everyone may like that opinion, but I do feel that it's important to at least interject. Can you get your protein in in your feeding window? Do I have one meal a day when I'm been traveling or maybe I went on vacation and I ate too much? Sure. But do I do that every day? No, but do we need to split hairs about OMAD? OMAD to me is one meal in a feeding window. It is not like a wider feeding window, like what Melanie does. To me, I don't think of that as OMAD. I just think Melanie has a gradual feeding window. How’s that? Is that a good way of describing it? 

Melanie Avalon: It's so funny. So, I guess, well first of all, super glad that you drew attention to, I think, the crux of the issue with the one meal day of getting in the protein intake. So, yes, that's definitely the major focus there. I guess the reason I feel, I feel like I'm having flashbacks to me and Gin talking, the reason I feel like mine is still one meal a day is, it's like being at a restaurant. It's literally a one meal situation. I start my eating. I'm like having the meal, it just happens to take, because I eat so much volume wise, this is all like whole foods, so it's all pounds of meat, pounds of cucumbers, pounds of blueberries, so it takes a long time to eat all of that. I like to eat slowly, so it's like eating one long slow meal. If you went to a restaurant and it was like a four-hour dinner type thing. 

That's why I feel like it's one meal because it's not like I'm having a snack and then not eating and then having a snack and then not eating, and then eating. It's like mealtime. If listeners are curious what I'm doing, I know people say that you should eat and just eat and focus on just eating, but I'm always reading two books at any one time, so I'm listening to one on Audible during the day to prep for the Melania Avalon Biohacking Podcast. I'm always listening to one during the day and then at night is when I read. I'm reading during those four hours and taking notes. That's why I feel like it's a meal situation. It really doesn't matter. It's semantics.

Cynthia Thurlow: No, I love that you have this whole process of creating digestive fire. You're starting kind of slowly and then building up to this crescendo and then it comes back down. For me, it's two boluses of food. I do know there are a lot of people out there that have differing interpretations of OMAD. It's not that one is right and one is wrong. I think that to me it makes sense to say OMAD is one meal, one food bolus. If you have two meals in your feeding window, great, but I don't think it should be a source of stress. Like ultimately eating less often should not be causing you more stress like really and truly. We have enough stress in our lives. We don't need to add more stress stressing about definitions of things. 

Melanie Avalon: I agree. I would comment that like an eight-hour eating window, like what Nancy is doing. I don't see how that would really be one meal. 

Cynthia Thurlow: Right, right. It really should be two. I mean, I'll give you a prime example. I traveled yesterday, I traveled this morning to come back from New York, and today is a much wider, fasting window because I literally have not been able to stop and eat. So, when I'm done with this podcast, I will go eat and I'll probably divide my protein into two portions because I'll probably eat a little bit and then a little bit more before I would close my feeding window just to make sure I get enough protein in.

Melanie Avalon: Got you. Yeah. That also goes back to knowing yourself and the unicorn comment and things like that. I do so well with just a massive, massive bolus of protein all at once. For a lot of people, I understand they can't handle that like they would need to separate it. So really, it's about knowing yourself. You commented on this. That's what I really love about Kimla's observation. She seems to be very intuitive with how she feels. So, yes. I think not getting lost in the semantics and like Cynthia said, stressing about the definitions and all of that. There's really no need to just focus on what you need to get out of your eating window.

Cynthia Thurlow: I think that's important because one of the things that I get the sense of is that there's anxiety around rules and there's anxiety around lifestyle changes. And that's definitely not what we want. We don't want to create more anxiety. We actually want fasting or digestive rest, like you do 12 hours of digestive rest. Like, it really should not be an added stress to your life. For those of you that are newbies, certainly lean in. There're so many great podcasts, like, over the last several years that Gin and Melanie did, and Melanie and I have been doing since May. And there's so much great information. Our books are great sources of information as well. Don't let it be a stressor. Just the concept of intuitive eating, intuitive fasting may not be accessible for everyone right now, but that's what we hope you get to a point where you can really lean into what makes your body feel good. 

You're an N of 1. This experimentation that goes on in terms of lifestyle changes. I know that the most I can eat in terms of a protein bolus is about 60 g. That's a good amount of protein for me in one meal. If I do 75, I'm probably going to be uncomfortable. So, 60 g is what I've been able to work up to but that didn't start right away. That was something I worked up to. We know most women are eating probably 40, maybe 50 g of protein a day. Most of us are not eating enough. Just be consistently working towards goals and that's the best that we should be able to do, right? 

Melanie Avalon: Yeah. I could not agree more. I find it so interesting, too. If I just ate, like, 40 g like you were saying, I would be starving, starving. Every time I go out to dinner, I get an entree, now it's my dessert, another round of meat. So good. So, so good. 

Cynthia Thurlow: I love that. It's funny Ben Azadi, who I know that you have recently recorded with, Ben, gets two dinners. And so, my husband the first time--

Melanie Avalon: Well, he does two. 

Cynthia Thurlow: Yes. Ben is, like, very tall and very lean. We were in Utah together, my husband and I, and his fiancée and Ben, and we're having dinner. And his fiancée, Natassia was like, “Watch.” And Ben's like, “I'll have two dinners.” And they were like, “What?” He was like, “Oh, yeah, we'll have two dinners.” And my husband and I were like, “What's wrong with that?" [unintelligible [00:55:49] one good-sized meal. 

Melanie Avalon: Does he have them at the same time or does he get them back to back? 

Cynthia Thurlow: Oh, at the same time. 

Melanie Avalon: Like I did on my birthday dinner. 

Cynthia Thurlow: Hmm-mm. And he ate it all. We were like, he's like a teenage boy, he has that capacity. I was like that's amazing. 

Melanie Avalon: I will get two entrees, or I will get an entree and then for dessert when everybody gets their dessert, I get another entrée. And I will say, so a little tip for listeners if anybody else wants to do this, I don't know if anybody else wants to do this. But especially if you're like keto or low carb, which I'm actually not, ironically enough, but it can be really fun to get an appetizer, like another round of sashimi or another steak for dessert. Let the kitchen know. If you're there late, they'll often shut down the entree part of the kitchen early. If you do want that for dessert, you need to let them know earlier on that you're going to be ordering that. Just a little tip for the one other person that wants to do this already.

Cynthia Thurlow: That's a good tip.

Melanie Avalon: They've cut it close sometimes because I've waited too long to tell them.

Cynthia Thurlow: [laughs] You also eat late at night, so they're probably like, “We're done.” Melanie's like, “No, I need more food.”

Melanie Avalon: Yeah. If you get an appetizer for dessert like the tartar, the carpaccio that comes from one part of the kitchen that might have shut down, and if you get an entree for dessert that comes from another part of the kitchen that might have shut down, the appetizer part of the kitchen is actually more likely to have shut down, I think. Now, I was thinking back to my serving days. That might not actually be true because oftentimes the dessert station is the same person as the appetizer station. In any case, the point is, ask your waiter or let them know. 

Cynthia Thurlow: Absolutely. 

Melanie Avalon: Should we answer one more question? 

Cynthia Thurlow: Sure. Our next question is from Spencer. Subject is “Breaking fast.” “Is there a proper way to break a fast? I feel like I want some items that are still a little unhealthy and seem to not really be losing weight on the scale. Maybe I need to also throw mine away but it got me thinking.” I'm assuming he's talking about the scale. “I keep hearing about there being a proper way to break a fast. Any thoughts on what I should be eating when I break my fast to provide me with the best results? I'm currently listening to the podcast and maybe haven't seen this question yet. Thank you.”

Melanie Avalon: All right, Spencer, thank you so much for your question. It's interesting because we have talked about this question on the show, seeing as how many episodes we've had, probably multiple times. But I think there's a unique spin we can give on answering at this time because normally when we have answered this question, I think it's been more in the context of how to ease your digestion, how to help heal leaky gut. Opening with things like bone broth and with gentle things you can digest. I don't know that I've given the perspective before of how to break your fast with specifically weight loss being the goal. And so, something that occurred to me is that and this is very individual, I think knowing how your body responds with insulin, you don't have to actually know the insulin number, but your perception of responding with blood sugar swings or not to different foods can be very helpful in the ordering of your food.

Because, for example, I mentioned before my order, my crazy order, oh, I'm so happy that we're answering this in here because this works so well together. The reason I do that order is very specific. It's what provides me well, hey, I can digest it well, but it provides me the most-- I always wonder, is it satiety or sha-city? I say satiety, right? But can it be both? 

Cynthia Thurlow: I say satiety, and I can assure you that after doing the audiobook for my book, the producer made sure that every word was enunciated and properly, I mean, everything. Yes, you say it correctly.

Melanie Avalon: Great. I have the most satiety with my personal pancreas and my personal insulin and my personal blood sugar regulation. When I open with the wine and cucumbers, like, that doesn't make me ravenous, it doesn't make me have blood sugar drops. Then I eat the massive amount of protein, which I find very satiating. The reason I actually eat a ton of fruit at the end is because I have found that mitigates what I either perceived as reactive hypoglycemia when I was doing low carb or might not have actually been reactive hypoglycemia. It might have been, we talked about it before, there's a name for it. I think it's like, idio--. It's basically feeling like reactive hyperglycemia, but it's actually not. You actually have normal blood sugar levels, but you feel like your blood sugar is dropping. When I was doing low carb and eating a mass amount of protein, I would be really satiated, and then I would go to bed, and then I would wake up starving. 

I think it was from my blood sugar probably dropping from the high protein intake. I do that pattern because it allows me to feel full, feel nourished and I don't get swings later. So, I think knowing yourself and experimenting to find what can you open your window with that will for you keep you full and satisfied, can be very helpful. For a lot of people, if they were to open with a simple carb-type situation, they might get a massive blood sugar swing that might make them ravenously hungry and make them overeat, even things like alcohol. Some people, the timing of the alcohol, depending on where it is, depending on their own alcohol metabolism, might make them eat more or less. Depending on that, the timing of if you're eating fat or not could make a difference. Basically, I would focus Spencer on finding the way that opens up the fasts that provides you with the most satiety.

Cynthia, what are your thoughts? 

Cynthia Thurlow: I am a fan of leading with protein into opening up your feeding window. Sorry, that would be my dog groaning underneath my feet, in case anyone's wondering. I think leaning into protein is important both for blood sugar support and also for satiety. For me, it's either protein and non-starchy carbohydrates, or it's protein and healthy fats, and that's typically how I break my fast. I just think protein is a really important macronutrient and one that I spend a lot of time talking about. I spend a lot of time discussing examples of protein and non-starchy vegetables. It could be chicken, it could be bison, it could beef. You could have arugula or spinach, or you could have broccoli or cauliflower versus sometimes when I sit down to have a protein and fat meal, it might be a piece of salmon, fattier cut of meat.

Those are the things I kind of lean into because it fulfills my needs in terms of getting my macronutrients in, but it also leaves me satiated. I can always tell if I haven't gotten those macronutrients right, because I will then be looking for more food when I'm done. But I think some degree of experimentation to find out what works well for you. I have some patients that want to break their fast with bone broth, others that want to take a light salad, like what Melanie does, where she has her cucumbers and her wine, and then she leans into the protein piece. I would do some degree of experimentation to find out what works best for you, but the protein is one that I always try to emphasize for most people.

Melanie Avalon: Okay, well, this has been absolutely wonderful. A few things for listeners before we go. If you would like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can get all the stuff that we like @ifpodcast.com/stuffwelike. And you can follow us on Instagram. We are @ifpodcast. I am @melanieavalon. Cynthia is @cynthia_thurlow_. That is all the things. Anything from you, Cynthia, before we go?

Cynthia Thurlow: No. Super excited for our upcoming recordings together and I look forward to getting feedback from listeners.

Melanie Avalon: Likewise, and because of when this comes out Happy New Year to you. 

Cynthia Thurlow: Happy 2023, hard to believe.

Melanie Avalon: I know. It's crazy. I'm excited for it, though. 

Cynthia Thurlow: Me too. 

Melanie Avalon: All right, I'll talk to you later.

Cynthia Thurlow: Sounds good.

Melanie Avalon: Bye.

Thank you so much for listening to The Intermittent Fasting Podcast. Please remember everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

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Dec 18

Episode 296: Berberine, Insulin Sensitivity, Glucose Control, Gut Health, Liver Health, Body Recomposition, AMPK Activation, Cholesterol Control, And More!

Intermittent Fasting

Welcome to Episode 296 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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SHOW NOTES

JOOVV: For A Limited Time Go To joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

scotts backstory

GMP certified

Episode 265: All About Supplements With Scott Emmens, The Supplement Industry, Purity, Potency, Testing, Toxins, Authenticity, Organics, Common Additives, And More!

Continuous glucose monitos

Go To melanieavalon.com/nutrisensecgm And Use Coupon Code MelanieAvalon For $30 Off!

metformin

combining berberine with metformin

the types of anti-diabetic medications

the benefits of berberine

what is berberine?

AVALON MAGNESIUM 8: Use The Code Melanieavalon For 10% On Any Order At Avalonx.Us And MDlogichealth.Com!

the history of berberine

the effect on the GI tract

dosing

The Melanie Avalon Biohacking Podcast Episode #93 - Shawn Wells

The Melanie Avalon Biohacking Podcast Episode #166 - Megan Ramos

the contraindications

meal timing

body Composition

AMPK activation

positive effects on the liver

dihydroberberine

LMNT: For A Limited Time Go To drinklmnt.com/ifpodcast To Get A FREE Sample Pack With Any Purchase! Learn All About Electrolytes In Episode 237 - Our Interview With Robb Wolf!

the journey of creating the supplement

purity testing

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 296 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time and get ready for The Intermittent Fasting Podcast.

Hi friends, you guys know how seriously I take my health routine. That is probably the understatement of the year. One of my literal non-negotiables that I talk about all the time that I use every single day of my life is getting my daily dose of red-light therapy. For years now, yes years, I've been using Joovv and I love it because it is so relaxing and so easy to use. You've probably heard me talk about Joovv before that's J-O-O-V-V. I use my devices daily to support healthy cellular function, which is the literal foundation of our health. If you've heard any of my episodes on mitochondrial health you know this is true. Having healthy cellular function helps give me peace of mind that my body is working efficiently and has the energy that it needs to get through the day. There are so many clinically proven benefits from red light therapy and I have personally so experienced many of them. I use the red light to naturally regulate my circadian rhythm. I wind down with it at night and wake up in the morning with it. Whenever I have any muscle pain or soreness. I shine my Joovv red light on it and the pain instantly goes away. It's actually shocking. I love it for skin health, it makes my skin glow. And you can also use it for things that I originally got into red light therapy for which was supporting my thyroid. Yes, I struggle with hypothyroidism and supporting hair growth. Aside from the benefits, I've been recommending Joovv for years because the quality of their devices is simply the best. Their modular design allows for a variety of setup options that gives you flexibility plus the treatments are easy and can be done in as little as 10 minutes. Although I tend to run mine all day as ambient light. All you have to do is relax and let your body take in the light. Joovv offers several different size options including a wireless handheld device called the Joovv Go. That is amazing for targeting specific areas around your body like hurting joints or sore muscles.

When I traveled recently and had torn something in my knee, I brought my Joovv Go with me, game changer, I don't know how I would have survived the trip without it. Health doesn't have to be complicated and Joovv makes it simple by helping what matters most, our cells. So, go check out the Joovv today and while you're there, Joovv is offering all our listeners an exclusive discount on their first order. Just go to joovv.com/ifpodcast and apply the coupon code, IFPODCAST to your qualifying order. Again, that's joovv.com/ifpodcast with the coupon code IFPODCAST. Pick up a Joovv today, some exclusions do apply and we will put all of this information in the show notes.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream.

And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of future generations. That's because ladies when we have babies, a huge percentage of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years.

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life and their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out. You can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well. 

And lastly, if you're thinking of making clean beauty and safe skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like the Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally completely worth it. So, again to shop with us go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now, back to the show.

Hi everybody, and welcome. This is episode number 296 of The Intermittent Fasting Podcast. I'm Melanie Avalon and I am here with a very special guest today, quickly becoming a crowd favorite. I am here with Scott Emmens. He is the chief operating officer and cofounder of MD Logic Health, which is an incredible supplement company that you guys are quickly becoming very familiar with because they are actually my partner in bringing you AvalonX. So, serrapeptase and magnesium that we've had and Scott is back here today. Well, first of all, because he's basically one of my favorite people in the entire world and I mean that from the bottom of my heart. But secondly, I am thrilled that we are about to launch-- actually when this comes out, we will have just launched my third AvalonX supplement. And it is something that I already personally had been taking every day in my life. Not only that, but it's something I've talked about on this show so, so much. Since this show is The Intermittent Fasting Podcast, it is something that really relates to metabolic health, blood sugar levels, how well you can do your fast, and then on top of that so many other health benefits that I actually didn't even really realize until sitting down to make my own version of this supplement. And that is berberine. I've been looking forward to this episode for a long. Scott, thank you so much for being here.

Scott Emmens: Hi, Melanie, thank you for having me on the show. I'm thrilled to be on and even more excited that we're you're finally launching berberine.

Melanie Avalon: I know, I feel like this has been such a long time coming. Okay, a lot of our audience is probably familiar with you because you've actually been on the show twice before you came on. We did a whole episode on magnesium with Cynthia. And then more recently, you did an episode with Cynthia for her creatine supplement because Scott also partners with Cynthia for her supplement line. Basically, we just really love Scott. But for those who are not familiar, Scott, super briefly, could you tell your backstory?

Scott Emmens: Sure, for those folks who may not have heard the first podcast when we went through that. I was in the biotech and pharmaceutical space for 25 years in a variety of positions, in marketing, sales, and sales leadership. I eventually got out to manage market side as well as operations and operational side. I really basically worked at some of the biggest pharma companies that people have heard of Takeda Pharmaceuticals, AstraZeneca pharmaceuticals, which was at the time part of Merck, Shire, and then became a startup expert, and worked my way into the C-suite of multiple pharmaceutical companies. And I really kind of around 2018 decided I was going to start my own biotech company and did that, very successful and literally right around 2020, when the pandemic first started, I'd decided that I really wanted to get into the wellness space. And we had sold our biotech company and I had three partners. And we decided, my partner and I, at the time thought, "Let's do a wellness line, make a wellness company." We had a connection with one of the largest US manufacturers. He is a partner in MD Logic as well. And we really just both believed in making people and keeping people well and letting them optimize their life through supplemental nutrition.

Melanie Avalon: Yeah, that's something that I really, really love working with you is you have seen the industry side of things. You know what you're doing. I have learned much and creating the supplement line, just what goes on in the supplement creation world, and how creating our own supplement line that is not a pharmaceutical, how it compares to that. And also, all of the crazy practices that go on in this industry it's a little bit shocking.

Scott Emmens: Yeah, it can be and I think that's where my pharmaceutical background really helps is making sure that we're going to do everything by the book. And by the book meaning people often see GMP on their label, it'll say GMP or GMP certified. And what that stands for is "Good Manufacturing Process." That's a compiled document from the FDA of very specific things you need to do, both in terms of the manufacturing of the product, the storage of the product, the cleanliness of the machines, the raw ingredients, the testing of the raw ingredients, as well as a number of other things including how you label even down to the font size of the label. And then including, of course, what you say about the product and how you make claims and that's where people tend to get in trouble.

We try to make the absolute best product we can. We have a great process for GMP. We have been audited by the FDA as most GMP companies are about every other year or so, and have a pristine track record and I am here to make sure that your supplements and MD Logic health supplements maintain that pristine record of both incredible quality, testing, and maintain the highest standards of GMP or above.

Melanie Avalon: Yeah, I am do grateful for this because honestly my goal in making supplements was, I knew I wanted to make the very best on the market. And it has been so refreshing to have a partner like you who is in line with that. And even every time I send my emails or I'm creating my content to promote the different supplements, I've come up with my list of basically the qualities about the AvalonX supplements. I say at the beginning that these are the only supplements on the market that are all of these things. And to my best of my knowledge, that's true. They're the only ones that are tested multiple times for purity and potency, free of all allergens. Scott and I have gone to great lengths to get rid of problematic fillers from the supplements, which has been a whole journey on its own, especially revisit, I'll put a link to it in the show notes the episode that we did on--. No, wait, "We haven't done the episode and serrapeptase yet, did we?" I think we talked about it though.

Scott Emmens: I think we did talk about it? But I've to go back into my memory log. But I believe we did talk about the serrapeptase, yeah.

Melanie Avalon: Did you come on this show for serrapeptase?

Scott Emmens: I think this might be my third appearance. I think I did do the serrapeptase first, then the magnesium, and then creatine. Yeah, I think serrapeptase was the very first one.

Melanie Avalon: My bad. So, this is your fourth time back?

Scott Emmens: Oh my goodness, how time flies. [laughs] 

Melanie Avalon: Oh, and you're having fun. [laughs] Okay, wait. In any case, listen to the serrapeptase episode if you want to hear the craziness with the fillers and the lubrication agents and also something that's incredible that really I think makes us stand apart is they are in glass bottles, which is very rare and unique in the supplement world. It's just been an amazing journey. "Shall we talk about our berberine journey?"

Scott Emmens: Let's talk a little bit about the berberine journey, I think the audience would love to hear what transpired? Why did it take us so long? And yeah, why don't you kick it off now?

Melanie Avalon: Okay, I started taking berberine when I started wearing something that our listeners are probably pretty familiar with which is the continuous glucose monitor. Just briefly a continuous glucose monitor is you put it on your arm, and it gives you a basically 24/7 look at your blood sugar levels. It is so eye-opening, so fascinating. Because when you're getting just doing a finger prick or yeah, a finger prick or blood draw for your blood glucose that's really just a snapshot in time. And it's not very telling of what is happening consistently. If listeners who like to get a continuous glucose monitor, you can go to nutrisense.io/ifpodcast and the promo code IFPODCAST will get you $30 off any subscription program to a NutriSense CGM, so definitely check that out. But in any case, doing a CGM really made me look more at my blood sugar levels and that's when I wanted to see what I could do to help lower it.

Berberine is considered to be the go-to "Natural Supplement" to address blood sugar levels. The go-to pharmaceutical to address blood sugar levels is metformin. There have been multiple studies comparing metformin to berberine and finding similar effects, which is incredible. So basically, berberine can be comparable to metformin in lowering blood sugar, lowering HbA1c, which is a longer term picture of your blood sugar levels and also lowering insulin without any of the potential side effects of metformin or the other negative side effects that can come with other metabolic health blood sugar controlling agents.

Scott Emmens: Certainly, I think that's absolutely correct. One thing we want to caution and make certain that we're not giving medical advice nor are we suggesting that anyone replace their metformin with berberine, not at all. What we are saying is that berberine has some remarkable properties and there's a lot of data, in fact, it's one of the most studied herbs or alkaloids out there. And we really feel passionate about all the benefits. In fact, I was stunned to see how many benefits there are with berberine as we really dug into the research, but again, we just want to caution, never add anything or take anything away, especially metformin for diabetic patients. So, just want to make sure that that's perfectly clear.

Melanie Avalon: Oh, yeah, I'm so glad you said that. And that's actually really appropriate because we got a lot of questions about that, Karina said, "How is it different than metformin?" Marie said, "Can you take it while taking metformin?" and Lea said, "Can it be taken if one is already on metformin, can it be taken instead of metformin?" So, just to dive deeper into all of that and to what Scott just said? Metformin as well as some other drugs that are used for similar purposes can have side effects. Metformin notoriously has gastrointestinal discomfort. Metformin cannot be used by diabetics or liver disease, renal impairment or cardiopulmonary insufficiency, and then some other related drugs like I don't even know how you say it. Is it pio?

Scott Emmens: Pioglitazone. I know that one because I sold it.

Melanie Avalon: I was like "Scott probably knows it."

Scott Emmens: Pioglitazone or pioglitazone.

Melanie Avalon: So, that one can increase the risks of distal bone fractures, bladder cancer, and edema. Here's another one Scott, sulfonylur--

Scott Emmens: Sulfonylureas?

Melanie Avalon: Yes, yeah, that was linked to hypoglycemia, weight gain, and cardiovascular damage. When we compare this to berberine, very little if any side effects, some people do have some GI issues potentially in the beginning, which we can talk about. But we can definitely dive into that. Because ironically, even with GI issues, berberine has a ton of potential benefits for GI Health. But besides that, you basically get all of the benefits of blood sugar control with a myriad of other benefits that we're going to talk about without the potential negative side effects of these pharmaceuticals. And there have been like Scott said, "We are not saying to stop your medications. We're not saying to even add this to your medications, that's something you would want to talk with your doctor about." Anything that you're doing, playing with your medications, definitely work with your doctor. That said, there's actually been quite a few studies looking at berberine in combination with metformin and finding beneficial effects, potentially that it might be a better approach, not saying to do this, work with your doctor. But potentially that combination therapy might be better than metformin alone because you can get more of the benefits with less of side effects.

Scott Emmens: Just going to add to that to just make sure that people make certain that if you add berberine to an antidiabetic, it can cause hypoglycemia. That's something you want to be cautious. Whatever the side effects of your prescription medication are, you want to let your physician know that you're going to take berberine and get their permission, make sure that the drugs you're on are not going to interfere with it because some drugs can have hypoglycemia on their own, when you add something like berberine, it can increase that potential. That's something people have to be very cautious of. Hypoglycemia can be a life-threatening condition as those folks who've had it know. It's interesting Melanie, the three drugs you mentioned, metformin which is sort of the gold standard, about 80% of diabetics are taking metformin or what used to be called Glucophage, the brand name, pioglitazone or TZD as they're known, which is an insulin resistance molecule, works on PPARalpha and PPARgamma. And then you mentioned was sulfonylurea which actually works on the pancreas to secrete more insulin. So, each one of those works differently. Metformin primarily works on the liver preventing gluconeogenesis and a little bit of insulin resistance. Then there's a TZD class pioglitazone, that works primarily on insulin resistance. And then there is some sulfonylurea class which increases your pancreas' output of insulin. They all work in different ways and they can all have different interactions with berberine, so again always talk to your physician. I think the real benefit Melanie is that berberine doesn't-- you don't have to have high blood sugar or you don't have to have diabetes to benefit, in fact, the real benefit we want to talk about today is what is the benefit for just people in general that want to optimize their health and optimize their cellular function and their energy. And that is where berberine shines.

Melanie Avalon: First of all, that was highly impressive, that you knew all of that. [chuckles] "I'm so impressed." Okay. Yeah, I'm so glad you said that because that is the exact same page that I'm on. And like I said, I came to it originally for blood sugar control and I think that's why most people think about it and it's a great reason to take it, but there are so many other benefits like whole body benefits. So, the questions we had, very simple, Kersey said, "Why do I need it?" Jennifer said, "What are all the benefits that come from taking it?" Amy said, "Will it help with insulin resistance?" And then what we will also get into Paul said, "Wondering what other health benefits it offers besides blood sugar regulation?" Andrea said, "Does it have any other benefits besides preventing lessening glucose spikes." So, we can dive deep into all of that. But to start off, I would like to give an overview of how it does work for blood sugar control because I think that really speaks to why it can be really beneficial to take when you understand that it's not like a pharmaceutical where-- With the pharmaceuticals they typically have a more singular approach to why they're working, compared to berberine that has all of these effects that can create this metabolic health.

For the blood glucose control, like Scott had mentioned it can be used for addressing insulin sensitivity and reducing blood sugar. It's so interesting because there are many studies. I had much fun preparing for this because there are many different hypotheses for how it's doing that. One of the main mechanisms and Scott mentioned this is that directly in the liver, it actually can reduce the liver's ability to actually create glucose or like create glucose and release it into the bloodstream. Because a mind-blowing fact-- I remember when I first learned this and it blew my mind because I think most people don't realize this, is that when people have high blood sugar levels most people think it is from what they're eating, which it is, but the actual, like 24/7 higher blood sugar levels, that's mostly being controlled by your liver. So, it's your liver creating glucose and releasing glucose.

Berberine actually inhibits that, it reduces enzymes directly in the liver that do that process, so then it can't happen. And interestingly, they have found that even though it helps insulin sensitivity, it doesn't seem to actually affect insulin production in the liver, so it's working independently of that which is really interesting. It can actually be directly in the gut reduce intestinal glucose absorption. So, just starting at the very beginning, it can stop the glucose from actually entering the body in the first place and that's by inhibiting a specific enzyme called a glucosidase activity. And that's an intestinal enzyme that actually digests carbs and converts them into more simpler sugars. Stopping that keeps you from actually absorbing some of those carbs in the first place. And then, beyond all of those enzymes and such it also can actually affect the transport of glucose throughout the body. And then on top of that, we can talk about the gut health potential of it. But a lot of researchers have hypothesized that its beneficial effects on the gut microbiome actually have a secondary effect of blood sugar control by the metabolic health state that is created from that so the anti-inflammatory state, the encouraging of short-chain fatty acid butyrate-producing bacteria when butyrate is created and gets into the bloodstream, it actually can help with glycemic control and the reduction of inflammation in the gut from endotoxin and LPS and the recruitment of macrophages and I realized I say all these words really fast and I know what they mean, but people might not know what they mean, so that's basically like the toxic byproducts that are created from "bad bacteria," because I realized saying good and bad bacteria can be a little bit simplistic. It reduces the inflammatory potential of the gut and inflammation is a key driver in metabolic issues. I can stop there a little bit. So, you want to jump in at all, Scott?

Scott Emmens: Well, first of all, great, I think it's a fantastic overview. And you can see how many different complex mechanisms berberine appears to have and why it has a broad base of positive impact across a number of organs and organ systems and then in particular blood sugar. I think we're going to learn a lot more as this molecule is again becoming, I shouldn't say molecule, this plant alkaloid is becoming hot on people's radar again. And I think at the end of the day, insulin is such a powerful hormone that when you can maintain blood glucose, which your audience is all about, the intermittent fasting audience really understands what blood glucose is about. But I don't know that we talk about the power of insulin and how powerful it is. I don't know if berberine lowers your fasting insulin and/or postprandial insulin meaning after a meal. My guess would be yes because it's lowering blood glucose with people that are already in normal ranges, well, then it's going to probably lower your insulin.

And we know in the presence of insulin, it's more difficult to burn fat, so it's all these different ways in which it slows the breakdown of glucose, it slows the liver's export or gluconeogenesis creating new sugar to push out into the bloodstream. All of the different mechanisms I think are fascinating and the more we learn about it, I think the more we're going to realize that this compound is going to have some very significant overall benefits for your wellbeing on a number of different organ systems.

Melanie Avalon: I'm glad you said that. Two things to comment on, the insulin piece. I did find studies showing a reduction in insulin. It was once where they were comparing it to metformin and they were looking at the long-term effects of that. And then there are so many studies talking about how it increases insulin sensitivity, that is definitely happening. But I'm so glad you said that because we probably should start with a really important question or we should get to a really important question. Jennifer said, "What is it? Is it a plant, a fruit, etc.?" April said, "I know serrapeptase comes from silkworms, but where does berberine come from? When did people start using it?" I realized we were saying like we haven't really defined what it is. So, it is a plant alkaloid and Scott, would you like to talk about the plant that it comes from? And why we chose the one that we chose?

Scott Emmens: There are different forms of berberine based on the plant source that it comes from. The one that's being used in our Vedic Medicine in India and is usually the form that is used in most of the studies you're going to see and I hope I pronounce this right, but it's Berberis Aristata I believe and that's spelled B-E-R-B-E-R-I-S A-R-I-S-T-A-T-A and that is the form that we've used and that comes from the Indian barberry tree or shrub and it is a shrub that belongs to the genus Berberis and it is found specifically in India. And there are many different species of this shrub. And it's typically found in the Himalaya area of India and Nepal as well as other places in Sri Lanka and that is the form that we’ve utilized.

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Do you know when they started using berberine?

Scott Emmens: I'm going to take an educated guess-- Because our Vedic Medicine goes back a while, I'm going to take an educated guess and say 1500 years ago.

Melanie Avalon: 3000 BC.

Scott Emmens: Wow.

Melanie Avalon: To treat diarrhea and dysentery. That's like when I very first started, isn't that crazy? That has a long safety record, I will say [chuckles] which we can circle back to.

Scott Emmens: So, I was only off by 4000 years, not bad. [chuckles]

Melanie Avalon: It probably got upregulated more little bit later when it first appeared. And like I said, that was to treat diarrhea and dysentery. And just to circle back a little bit to the GI Health aspect to really fill that out. There's been many studies on berberine and its effect on gut bacteria. And actually, we have a question about this, so I'll just tie that in right now. For example, Nikki said, "I've heard people say not to take it daily because it changes your gut bacteria, what are your thoughts on that?" Morris said, "This would be my question. I always cycle on and off of it, but I know Melanie does not?" And then Karen said, "Berberine is used as an herbal antibacterial/antimicrobial, which I was going to get to, so I'm glad she said that." She said, "In addition to the blood sugar lowering properties that you are focusing on, I'm concerned about negative effects on beneficial gut bacteria with regular use of this product, can you speak to that?" I'm super happy that people were asking me about that. There have been a lot of studies looking at its effect on gut bacteria populations, and across the board it tends to increase the "Positive good bacteria, specifically Bacteroides and decrease the more inflammatory bacteria specifically Firmicutes." Because those are the two that if you know about gut microbiome, you might have heard of them before, but there's been a lot of other studies, for example, it's directly antibacterial against E. coli and clostridium difficile. It can increase, I mentioned this earlier, the short-chain fatty acid-producing bacteria, specifically and I don't know if I'm going to say these right. Phascolarctobacterium, Anaerotruncus, and Acidobacteria, those are all short-chain fatty acid-producing bacteria that can help with intestinal integrity. And it also may inhibit a certain type of bacteria that has been connected to obesity, which is super cool. And we can actually get into the obesity, body fat bit in a little bit. Basically, it seems to have a very beneficial effect on gut bacteria. I would not be personally and again you can make your own decisions and choices, but I personally am not concerned about the effect because it seems to have a very beneficial effect. I actually wonder, Scott, I'd be curious about your thoughts on this, I hypothesize that people who might sometimes be experiencing negative side effects in the beginning, it might be because they are playing with the populations of their bacteria and are experiencing a die-off effect because whenever you go after the bad guys, you can get negative side effects from that. It's a good thing because you are moving the needle towards more beneficial population. There might be some side effects in the interim. And, for example, I found there was one study looking at berberine compared to metformin and it found that all of the side effects only happened in the very beginning of the trial, and there's a longer-term trial. if you are experiencing gut issues in the beginning, I would suggest maybe lowering your dose so we can talk about this later and maybe sticking it out a little bit. But Scott, what are your thoughts?

Scott Emmens: I think your hypothesis is a pretty good one. Meaning anytime you're detoxing the body even if detoxing is a "Good Thing, " you know that you're killing off a lot of bad bacteria, and maybe you're not using a binding agent or you've got a lot of bad bacteria in your gut that could cause inflammation, the destruction of those can release toxins. Yeah, that could very well be, I think, that's a little speculative, but it's a reasonable theory. But what is pretty consistent is that the metformin side effects and the berberine side effects both seem to happen upfront. And the solution to that in the Glucophage world, is what doctors will say and many patients have probably heard this wording "Start low and go slow." if you are sensitive, you've never taken berberine before or you take two pills on day one and you feel a little bit of GI upset then back down to one capsule 500 mg once a day, kind of stabilize yourself and then you can work your way up. And that's really, I think, always goes for any medication or supplement, you always want the lowest effective dose. Now, we came out with the 500 mg, had a lot of discussion about what to recommend in terms of dosing, one to three capsules a day is where it landed because the majority of the data suggests that on the low end, 500 mg is right. On the higher end, 15 mg is correct. Many of the studies have been done with 500 mg three times a day, I don't think you want to take 1500 in one shot, really, you want to break that up over three doses. But that's where we found the sweet spot was. So, if people are experiencing side effects, I would say start with 500 and just slowly work your way up.

Melanie Avalon: Yeah, I'm so glad you said that because we had had obviously a lot of questions about dosaging, like Jennifer said, "How much can or should I take?" Claudia said, "How much to take? What's the dosage?" Anna Maria, "When is the best time to take it to optimize results?" Amy, "Is it best to cycle it or take it every day? Should one take it at the same time every day or time it more specifically to be ingested before you eat a potentially glucose-spiking meal?" Cheryl wanted to know "Do you take it with food or on an empty stomach?" And Nydia wanted to know "Does it break the fast?" Teresa also wanted to know "Is it something that you can take daily? I know Shawn Wells listed as one of his most recommended supplements. But I've heard Cynthia Thurlow say that she has people cycle it. I will put a link in the show notes, by the way to an episode I had with Shawn Wells on the Melanie Avalon Biohacking Podcast. I adore Shawn and he is one of the go-to people in the supplement world, he's just a phenom when it comes to that, but yeah, to answer all of those questions, Scott just gave a really nice overview of the dosage and we thought long and hard about what dosage to do for it more. Again, going back to what we talked about in the beginning about the craziness with regulations. It's crazy how you have to like figure out what you can actually say on the label to get the dosage that you want. It's hard to describe. But basically, I had a very clear idea of what I wanted to say. And it had to go through Scott and like the legal team to get it on the label the way I wanted it.

Scott Emmens: That is correct. And I think, that's why we take those precautions because it's important for the public to make sure that what we're saying is in line with what is appropriate, but also to make sure that we're following all of the guidelines, guidance, and making sure that we are in compliance to that. That comes from 25 years of pharmaceutical lawyers pounding into me what I can't say. I want to make sure we do that, but on the other side, it's also what is it that we can say that will really make sure we're giving a clear specific guidance that is in the best alignment with what the data and the research suggest. And I think we got there and I think to your frustration, Melanie, I think a lot of people assume that the supplement world is a free cowboy world. But there are very stringent guidelines on labeling, claim that you make on that label, what you can say, what you can name it. And even down to like, the font size and how you list the ingredients and what size, certain ingredients have to be in the font size. I mean it gets very particular. So, again, going back to this, "What is GMP?" If you're following CFR 21, which is the regulations on how you label a supplement properly along with what this GMP mean, it's extensive and I think that's been one of the learning lessons that you have come across as well. How many things you have to do to make sure you've done it? But then again, how many other companies want to escape that edge that goes 75 and a 65 and make sure they don't get a ticket. And we'd rather go 65 and 65, then do the 75. And I think that is an interesting learning from a lot of people that we work with in this space, physicians [unintelligible [00:39:42] and so forth.

Melanie Avalon: Again, just another reason I've been grateful to work with you because you get all of this and I have learned so much, and it's just really been a really amazing incredible experience. So yeah, the dosage we landed on that we mentioned is based on the majority of the study. Probably the majority of the studies are 0.5 g or 500 mg, those are comfortable three times a day. But it ranges from, actually in the studies it's not normally on the lower end, but it can be, so I wanted it to have it, a minimum of like 500 mg up to 2 g, which seems to be the upper limit. That's the way we had it working on the bottle so that it could cover that range. I will say-- because we got a question because I had Megan Ramos on the Melanie Avalon Biohacking Podcast, she's amazing, definitely listen to that interview with her. She shared a negative experience she had with berberine experimenting with it during pregnancy, I think.

Scott Emmens: Yeah, that's a no, no.

Melanie Avalon: Yeah, and she was taking 2 g which again is the upper limit of that. For example, Lucy said, "Megan Ramos mentioned a few times that she was very sick with a negative reaction to berberine when she was on the Melanie Avalon Biohacking Podcast. I would like to know the main contraindications for berberine and how to avoid similar situations." Again, in that situation, revisiting that episode, Megan was taking the upper limit and while she was pregnant, I would start not at the upper limit, not take it during pregnancy or work with your doctor. So, definitely, you just want to be aware of all factors involved.

Scott Emmens: So, here are the contraindications, there're a few but they're fairly rare except for pregnancies. The first one is, if you're on Cyclosporin-A, you do not want to take berberine because it can have an interaction with the CYP43A for enzyme in the liver. Then you also do not want to take berberine with warfarin or thiopental, I think I'm saying that right, thiopental or tolbutamide because it can displace them from increasing the blood and increase the blood toxicity of those particular drugs. Warfarin has what's called the very narrow therapeutic index. Some of these other drugs do as well. If you increase just their bioavailability a tad or decrease it a tad it either will become toxic or can become ineffective. Those are contraindications. And then macrolide antibiotics such as azithromycin and clarithromycin may also interact, they're not contraindicated, but they are certainly something that you do not want to take berberine with unless you absolutely had to, based on a physician recommendation. And lastly, we do not want to take berberine if you are pregnant, that's contraindicated as well.

Melanie Avalon: Yes, I'm glad we could speak to that as far as does it break a fast? No, it will support your fast if anything. I actually don't take it the way most people take it. Well, first of all, I'm not eating three times a day. I'm not taking it three times a day before meals, I actually take it in the morning in the fasted state. And then I actually don't take it later before my meal. Although I probably should experiment with doing that come to think of it that would probably be beneficial. The reason I was doing that was I was just seeing the biggest spike in my blood sugar in the early part of the day, but you can really experiment and find what works for you. But typically, people are taking it before meals. Yeah, do you have any thoughts about that, Scott?

Scott Emmens: If you have a CGM, you want to experiment with that or if you take your blood sugar through another means, I think you want to experiment with that. For me, personally, I'm going to take one probably on an empty stomach starting when I start my new regime in January. Typically, when I take berberine, it's going to be about an hour to an hour and a half before my meal because I want to get the berberine inside my intestines, I want it to be metabolized and we're talking a little bit about the metabolites and the active metabolites of berberine. I think about an hour to an hour and a half prior to my meal to ensure that the maximum blood plasma level is there and that the metabolites are beginning to get into my system. That to me seems reasonable. Now, if you have GI upset, it's probably going to be the best to take it closer to your meal. I think you want to experiment with that both from a what's most comfortable for you? And then if you have the ability to measure your blood glucose, what's working best for you? For example, there's someone who owns a CGM company, he has a podcast. I've just listened to his podcast in preparation for the show and he had some limited success with berberine pre-meals. 

Now keep in mind, this is someone who is on a very restricted diet, he understands insulin, he's probably already in a low-insulin, low-glycemic state to begin with. He didn't see a lot of change with berberine before meals, but when he took it for the fasting insulin in the evening, he noticed dramatic decrease in his fasting insulin in the mornings. And that speaks to the liver part of gluconeogenesis because your liver's job with gluconeogenesis is to keep you from going into hypoglycemia while you sleep. And when you are diabetic or you have blood sugar issues that are beginning, your liver might be getting the wrong signal thinking, "Hey, we don't have enough glucose." So, it's pushing glucose out even though your glucose is already very high. So, based on the various ways that seems berberine works, I think each person's body type and where they're at, it's going to have a different impact, my personal recommendation for me is going to be to try to start taking it on an empty stomach, hour and a half before meals is what I currently do. And then I might experiment with a pre-evening dose.

Melanie Avalon: I'm so glad that you mentioned body fat. I know you're talking about it in a little bit different context. But I do want to talk briefly about the super cool effect that berberine can potentially have on body composition especially because I know a lot of people-- one of their main goals, possibly why they're listening to this podcast is for body composition effects. And there's been a lot of studies looking at berberine's effect on body re-composition with or without weight loss. So, it seems that in particular berberine can actually reduce the levels of inflammatory fat specifically, so visceral fat is a type of fat that is found surrounding the organs. And it's actually the type of fat linked to metabolic health issues compared to like subcutaneous fat, which is found underneath the skin and which is considered to actually be more benign when it comes to health issues. So, berberine has been found in some studies, it leads to weight loss specifically reducing visceral fat and in some studies, there's actually not weight loss, but there is a shift in the type of body fat, which is super cool. Basically, it's making your body more healthy when it comes to fat. Mice treated with berberine have actually been found to have shrunken adipocytes. Basically, their fat cells are smaller which is super cool. Other studies basically propose that the anti-obesity activity of berberine can involve in part not only decreased size of lipid droplets but actually also the number of lipid droplets. There's a study suggesting that berberine actually increases thermogenesis in brown and white tissue.

Scott Emmens: Yeah, that was very interesting to me.

Melanie Avalon: Yeah, basically increasing burning calories in your fat tissue, which is very cool, because you really want to stack especially with our modern diet environment, you want to do everything you can to stack the cards in your favor, to have a healthy metabolic profile when it comes to body fat. And it can be hard to do that, especially when there are cellular mechanisms involved. And anything that can really affect that, like berberine, can definitely be something to try. It can also discourage the creation of new fat cells "super cool." And that's actually by affecting transcripts and factors that are involved in creating fat cells in the first place. And then, for example, a review of five studies that encompassed 1078 women and you know I love when we got studies in women, found that it did indeed induce a redistribution of fat tissue, specifically reducing that inflammatory visceral fat that I spoke of. And speaking of the inflammatory potential, not only is it reducing the amount of inflammatory fat, it actually may make fat in general less inflammatory by reducing the recruitment of macrophages to fatty tissue. So, macrophages are basically-- for these things that go in-- and you can think of them like Pac-Man, they go and gobble up things. They're good, we want them in our bodies. They deal with getting rid of waste and fighting pathogens and things like that. But when you have an overabundance of them, it can be a very inflammatory state. And a lot of people's resistant fat, when people really just struggle to burn fat. It can be because the fat itself has become inflammatory, and it becomes resistant to fat burning.

Scott Emmens: Are you referring to brown fat versus white fat in adipose tissue?

Melanie Avalon: It found that it activated thermogenesis in both of them which is super cool. Did you find one showing that it increased brown?

Scott Emmens: Yes, I found a few studies that say that berberine promotes the recruitment and activation of brown adipose tissue in mice and in humans, which was pretty interesting. There was another study about berberine-activated thermogenesis in both white and brown adipose tissue, but one of the things I thought was so interesting was that it does seem it can help your body promote brown fat, thus thermogenesis and brown fat is packed with mitochondria. It keeps you from shivering, that's why babies have a lot of brown fat versus white fat, white fat that being the inflammatory version, brown fat being more of what they call an activated fat which has its own mitochondria in it and really actually is more of a positive energy-burning fat than white fat is. So, that I found really interesting. And even so to get to your point, if you don't lose weight, if you're just shifting that fat from the more inflammatory to the less inflammatory, more highly energetic fat, I think you're going to reap a lot of benefits.

Melanie Avalon: I'm so glad you said that, you really revealed that you haven't a grasp of what's going on because brown fat and white fat like Scott mentioned, brown fat is really high in mitochondria, it's activated by cold is something that activates it, it actually helps you lose weight which is ironic because it is fat, but it creates heat. And it basically wastes energy. But the thing that you said, Scott that I mean, I already knew this, but maybe made it aware that you actually really know what you're talking about. I think a lot of people think brown fat and because they associate it with cold, they think "Oh, that's like shivering," but it's not, it actually keeps you from shivering because the alternative to brown fat is to shiver, basically.

Scott Emmens: Exactly, and do you know how I know that, Melanie?

Melanie Avalon:  No.

Scott Emmens: Ice baths have taught me that. [laughs]

Melanie Avalon: I was going to say cryotherapy.

Scott Emmens: Yes, I am an ice bath guy. And I'm about to embark on a January 1 through February Polar Plunge for mental health benefits. I am currently back in training filling my tub up with giant hunks of ice and getting in there for 10 minutes or so to adapt. And I discovered the benefit of brown fat as I was really-- This goes back to 2016 when I first began doing ice bath, which by the way changed my life in so many ways. But that's when I discovered what brown fat was, why it was important and how I adapted to the cold over time by creating more of this brown fat. I mean, the first time I got in an ice bath, it was 60 seconds of pure shivering and agony. Three months later, I could sit in there for 8, 10 minutes at 40 degrees temperature of Fahrenheit and not shiver at all. In fact, one time I stayed in long because I hadn't shivered. I did get a little hypothermic, so that's how I learned about brown fat and white fat was through ice bath.

Melanie Avalon: Yeah, that's super cool. I remember Scott and I met. When did we meet? Spring of 2021?

Scott Emmens: I think you're right. I think it was April of 2021.

Melanie Avalon: Yeah, because we launched serrapeptase in 2021.

Scott Emmens: November. Yeah.

Melanie Avalon: Yeah, I think that was one of our first conversations way back in the day.

Scott Emmens: First conversation was ice bath and then followed by a lot of discussion on infrared, near-infrared and therapy and saunas, which I'm also a huge fan of, by the way.

Melanie Avalon: Yes, so many things. One last health benefit-related thing I think we should talk about, especially with this show one of the reasons people often do fasting, well, it's not the reason, but something we've talk about a lot with the benefits of fasting is how fasting stimulates something called an AMPK, which is basically a fuel sensing enzyme. It plays a key role in how our bodies use energy and it's activated by stressors like calorie restriction, fasting, and exercise. It is associated with so many health benefits like you want AMPK activation, it helps with longevity, metabolic health, inflammation, so many things. Berberine has found to be a very potent stimulator of AMPK, which is awesome. And then another fasting-related thing we talk all the time on here about autophagy which is activated by fasting as well. And it's where the body actually goes down and breaks down problematic proteins and recycles them. It's like a cleanse on the cellular level. It's very, very important for metabolic health and longevity. And berberine has also been found to be a stimulator of autophagy, so that is awesome.

Scott Emmens: People underestimate the importance of healthy autophagy getting rid of cells or what they might call zombie cells or mitochondria that need to go because they'll contaminate the other healthy mitochondria around it. I think autophagy is a tremendous benefit. And obviously, the AMPK there's a plethora of data on all the various things that impacts across your longevity and health span. One of the things that I don't think we touched on but, I know came up in literature quite a bit, is the positive benefits of berberine on the liver. And I'm a big guy on liver. I think if your liver is not functioning right, if it's not making bile, if it's not digesting your toxins properly, you're going to end up in trouble. And so, to me, I think that the liver benefits of berberine have probably underestimated at this point. There's not as much data and studies as I'd like to see. But there is definitely data to suggest that it works to support liver enzyme health, liver function in the presence of toxins, and I think that is really important. When you look at the overall effect of what berberine is doing to your point earlier, it's working on AMPK, it's working on glucose, it's working on your gut microbiome, it's working on your liver and your liver's function. And I think all of these things combined lead to, in my mind, one conclusion which is, there's something about this particular product that allows your body to function in an optimal level while keeping the blood glucose down, supporting mitochondria, supporting liver health and I think it all ties back to, if blood glucose and insulin are lower, then you're going to have a cascade of positive effects across your body. And I think that is why CGMs have become so popular as people realize that if they can keep their blood glucose at a reasonably modest normal level without having huge spikes throughout the day, that overall is going to lead to a longer and healthier lifespan. The data on that is pretty convincing. That's where I think berberine shines as this molecule plant alkaloid that just has so many benefits. So back to the liver, there is a couple of studies on liver enzymes and also on liver function. I would encourage people to take a look at that research. Again, of course, always speak to your doctor if you're taking anything for liver disease.

Melanie Avalon: I'm so glad you mentioned that as well because that actually goes really well with one other health benefit I want to touch on and it also involves the liver, so glad we're talking about it. And that is the role of berberine on cholesterol levels and lipid panels. Margaret said for example, "Is it okay to take it long term to help lower cholesterol" and we can speak to the long-term aspect in a bit but just as far as the cholesterol side of things. Not only does it directly reduces the absorption of lipids into circulation from your gut, because the whole caveat there is dietary cholesterol is not necessarily the primary driver of problematic cholesterol levels. It's more at least in my opinion, the creation of endogenous cholesterol and what's happening with that. And the effects in the liver on cholesterol and lipids is-- I mean, there's so many so.

It can promote the liver's LDL receptor mRNA expression to beneficially modulate LDL levels, it can directly inhibit the creation of cholesterol and triglycerides in liver cells. In rodent trials it's been found to inhibit NAFLD, nonalcoholic fatty liver disease in mice fed a high-fat diet, which is huge and in human trials have actually found that berberine supplementation can reduce liver enzymes in patients with type 2 diabetes and so going back to what Scott was saying about liver health and it can also reduce fatty acid synthesis directly in the liver and a lot of transcripts and factors related to fatty liver. And for example, there was one study in humans and not only did they find decreased body weight and BMI in those on berberine, but what was super cool about the study is it had people do berberine and then have a washout period where they were not taking the berberine and then go back on the berberine. And they found that their triglycerides, their cholesterol, their LDL, and their HDL all improved based on when they were like taking the berberine. When they were on the berberine, it improved. When they went off, it went away. And then when they went on again, it approved again. Lots of potential benefits there with cholesterol and lipids.

Scott Emmens: Yeah, I totally agree. And the one part I'd like to focus on that is with triglycerides. Having been in the diabetes universe for 15 years or so, one of the things that I spoke with when I worked with endocrinologists, those are the specialists that treat diabetes, the thing that the cutting-edge endocrinologist would tell you is if you see someone that has a relatively high fasting glucose, but they are not diabetic, but their triglycerides are above normal. He's like that person is going to have diabetes if they don't change their lifestyle in a few years. Triglycerides are the leading indicator like "Hey, you're on your way to diabetes if you don't change this." Your body is basically taking this sugar and trying to figure out what it's going to do with it because it can't do something. This isn't the scientific way to say this, but basically, your triglycerides are this canary in the coal mine, that if they're high, but your blood glucose hasn't quite broken, technically the diabetic limit, you're probably on your way there. That's something you really want to look out for [the fact that it does have these studies that show that it can have a positive impact and support the body's ability to reduce triglycerides really says something to me about the way that it's working for blood glucose.

Melanie Avalon: And I think that actually ties in nicely to something that I want to talk about, which is this specific form that we chose because we got a lot of questions about dihydroberberine. for example, Teresa said, "She wants to know the difference between berberine versus dihydroberberine." Erin said, the same thing, "What's the difference between those two?" Suzie said, "What is the difference between them and what is the best?" Paul said that "He actually did better taking dihydroberberine that he didn't have the bloatation and the gassy issues?" And then Amanda said that --Oh, this is something that we can speak to the absorption levels. Amanda said, "Mike Mutzel talks about not using the highly absorbable kind," which presumably, I'm assuming is the dihydroberberine, as that's how berberine is effective in the gut by not being highly absorbable. Just speaking to what you were just talking about Scott with all of these over-encompassing effects and many things that are going on, shall we talk about? Because we debated for a long time about? Well, more so in the beginning, I think once we got to an understanding about it, we felt pretty good. But we were looking at? Should we do a berberine or should we do a dihydroberberine? Dihydroberberine is a newer form of berberine, at least from being like sold and marketed, which is said to be more absorbable and said to have a more potent effect on lowering blood sugar? We chose not to do that. Scott, would you like to explain a little bit why?

Scott Emmens: At first, it was two things. I think this goes back to my experience with prodrugs and metabolites prodrugs and then also looking at the data. Of the 30 years' worth of research that we have a good grasp on and there's a ton in the last 15 years, all of it is on berberine or the vast, vast majority I should say. There is very little data on dihydroberberine beyond just either its increase of "plasma level," but plasma level is not really what separates Berberine from the pack. I'll give you an analogy and tell me if it's apt Melanie. But with CBD, for example, "If you get a pure 100% isolated CBD, you may have no effect from it because it's not just the CBD, it's the CBD, CBG, it's the other cannabinoids inside that product that give it an entourage effect along with terpenes and other things that create that. Then if you add the other factor into metabolites from a prodrug is a drug that goes in as an inactive substance. And then your liver converts it into an active substance. Well, berberine happens to have no less than four active metabolites and as many, in some reports as 17 metabolites. And we don't know what those metabolites do, but it's pretty clear, and here's a direct quote from an article. Let me just make sure I get the title. "This is the metabolism of berberine and its contribution to the pharmacological effects." 

And then let me read this quote because this wasn't something we had focused on a ton in the beginning, but we discussed it, but the more we did the research, the more evident it became that there's something unique about it. "Even though berberine possesses a low oral bioavailability, it has exhibited marked biological activities in vivo which is in people and concentrations of its major metabolites such as berberrubine, thalifendine, I'm going to say these wrong, I'll butcher these names, demethyleneberberine, and jatrorrhizine, that is butcher of those names, but they are relatively high. And then it says, "These reports indicate that the metabolites of berberine may be active constituents which are representative of the biological activities of berberine in vivo and I mean that sums it up that there is something unique about berberine despite this, "Low bioavailability." Study after study shows that it works and then now we're getting more and more studies that are coming in. And our ability to measure these metabolites that are coming in active tablets, meaning your livers convert it into a new active form of berberine. They are actually also stored in your various organs, like your liver, in your kidneys, in your brain and other places that allow for these other properties of berberine or that we suspect based on the data allow for these other properties of berberine. By isolating one particular compound, yes, you may get less side effects, but you may not get all of the benefits of berberine. And I think between that and the fact that the data is very consistent on berberine, says berberine is the way to go. Now, we might decide to do a dihydroberberine in the future for some other specific reason, but if we're looking to get the maximum benefit across the spectrum of berberine, then we wanted to use the whole berberine plant.

Melanie Avalon: I think it's so interesting, Scott found, I don't know if it's the one that you were just speaking about, or if it was a different one. But you found this really great article, which basically speaks to this issue that people will say about berberine, which I find really ironic because people will say it's not very absorbable, like an issue basically, and that we need to fix it. But it's just really ironic, because all of the studies for so long and then it's been used for thousands of years, have been working with it in this form, so clearly, it's working in this form.

Scott Emmens: And then all of the data is in this form. When they saw the studies we read to you today, all of the data we've read to you today is from berberine. And so, you could take a chance that yes because it's more "Absorbable" and less impactful in your gut. Well, okay, maybe that works, maybe that doesn't just because it's higher in your plasma doesn't mean that it's high or concentrated in your organs, which may be the very benefit we're getting. I think you're right, it is ironic that we think we have to fix a product.

Melanie Avalon: It's pretentious.

Scott Emmens: Yeah, we have to fix a product or a natural alkaloid that has decades, in fact, let's go back to your earlier number of 4500 years of use. So yeah, I'm pretty confident berberine is the way to go. And for those folks that do have jabs and again, I would say, take it closer with your meal at first, start low and go slow. So, try one, just take one a day for a while, get your body used to it. You had mentioned maybe it's a detoxification process, go low and start slow. But yeah, I think you're exactly right. To say that this other form is better with no real data, I don't think is the right way to go. Is dihydroberberine, does it have some advantages? It very well could. But when we're talking about all of the data, and all of the studies, and these active metabolites, this is the product that I feel most comfortable taking.

Melanie Avalon: I think that's the key thing to focus on, which I'm not saying at all, that creating an isolated form of anything might have more of a benefit for maybe a certain goal in mind, like you might be able to finesse it to, have a specific intended effect. And maybe with dihydroberberine, maybe people, but again I would just need to see more literature and experience with people. But maybe it does work better for some people, which is great. But what's interesting is often rather than saying-- when people pause at dihydroberberine, for example, often rather than saying, this is another form of berberine that may be more beneficial for certain people for certain goals. It's positive, like berberine isn't very absorbable, they are like discard. They discard the entirety of the berberine literature, which makes no sense. And we do this with other things. We do this with turmeric and curcumin. People will say that we need to take our curcumin supplement because it's not very bioavailable in turmeric, when people have been using turmeric for the benefits for so long, people do it with resveratrol and wine. It's a very common thing that people do.

Scott Emmens: Or like a polyphenol versus an individual phenol. And that's why I love this one specific sentence, which is even though berberine possesses a relatively low oral bioavailability, it has exhibited marked biological activity in vivo. And the concentrations of its metabolites such as I butchered those, indicate the metabolites have an active constituent that represents significant biological activities of berberine. And in fact, berberine studies have revealed metabolites have shown similar bioactivity and it goes on and on. And there is something unique about it, the way that it is absorbed is not directly correlated to plasma. And in fact, it might be within this article or the other one that I had sent you, it says that, "Part of the reason that the plasma levels in berberine aren't high is because it's getting pushed into the organs where it needs to be and that was mind-blowing to me.

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Also related to our whole creation process. We had that question at the beginning about dihydroberberine versus berberine. And then when we decided on berberine, it was time to actually create it and Scott. Shall we tell listeners a little bit about our journey? [chuckles] 

Scott Emmens: Journey is a good way to put it, [chuckles] would you like me to start?

Melanie Avalon: Sure.

Scott Emmens: So, breaking the fourth wall a little bit, Melanie had some very specific criteria, as usual, all legitimate. And we began this pursuit for the perfect berberine. And one of the berberines that we looked at that had this really great story in this great, it's organic from the Himalayan Mountains. And then there was another one from the western part of the country, yada-yada, handpicked, etc. However, when we tested those berberines, they came back with both impurities and their potency level was remarkably low. And then I did a little more research and found that these companies also had some FDA warnings. There's a thing in the FDA when you have a GMP-certified facility, it's not just about the source of where you get the product. The most important thing is, have you done the four critical components of testing, which is strength, identity, purity, and compliance composition? And what we do at MD Logic Health and this is why I think we are so selective about who we partner with in terms of suppliers and also co-branding partners such as Melanie is, we want to be the best of the best, just like Melanie. What we discovered was that these other berberines not only failed to meet the specifications that were required but that also did not meet GMP, meaning the facilities themselves had multiple 43 notices or 402 requirements, which basically means that they were citation with significant issues in terms of their facilities GMP. Some folks, well where's it sourced from?

Well, that's important except the most important thing is have you done the correct analysis to protect yourself against heavy metals, purity, identity, strength, toxins, etc. And when we get a product, in this case, berberine, we quarantine everything that comes into our facility. It has been tested before it is allowed to come in for those four things back to what is the identity? What is the strength? Or the amount of active ingredients? What is purity? Meaning, are there toxic metals? Does it meet all of the standards that we're referring to? And is it meeting all of the compliant FDA requirements for purity, potency, etc. Those four things are done before that product even comes into our doors. Unfortunately, two of those products failed to meet our standards, which obviously disappointed us, but we were not going to allow faulty product or subpar product into the process. And when I went to look back at the companies that were utilizing these products, what I discovered is they had multiple 43s including but not limited to various toxins, lack of doing the standard studies, and in shocking fashion rat feces in a number of their herbs.

Melanie Avalon: Was it in the herbs or in the facility?

Scott Emmens: It was in the facility. I don't know whether it was in the herb or whether it was contaminated in the facility, or how but it was tested and found in the facility, meaning that multiple of their herbs had rat feces in them. And this is a pretty well-known brand, which we're not going to mention. But the fact of the matter is that they had obviously either not quarantined it and brought it in with the feces or the feces was in the facility and they hadn't done their due diligence on making sure that the facility was properly protected against those types of things. When a company says they're GMP certified that's one thing. But they need to be following all of those GMP tests. The reason that we quarantine the product before we bring it in, is if that product is contaminated you run the risk of contaminating your entire line. That's why it is quarantined and tested prior to its entry into our facility. 

Once it's tested and it passes all of those tests, we then bring it into the facility and then we do again, what's called batch testing. And we retest that same product after it's been manufactured to make sure it still meets all those specifications and has the amount of milligrams we'd say it has, it has the proper ingredients, and it still meets all of the same parameters to make sure that it didn't get infected or contaminated along the way. it's not just important to do it after you've created it, it's important to do it before it enters the facility. It's important to make sure you follow all of the criteria that GMP lays out in terms of where you store your product, how high you store it, what temperature you store it at, all of these things add up to what's called good manufacturing process. It's more than just testing for purity, strength, identity, and compliance. It's also, "Did you do the proper testing on how long it's going to last on the shelf, for example? What temperature did you expose it to? Did you have a CoA from the supplier of the ingredient and then did you also subsequently test it?" Some people will take the CoA from the supplier as the gold standard and then not do their own testing. That's not the way to go, because they may have gotten one sample to pass that test. But they can give you a different version or a different sample or a different supplier. And sometimes companies will change suppliers without then doing a retest of the ingredient. And then of course is not kosher either. You've got to make sure that you're doing GMP, the way GMP is written. And that is why there's a difference between us and folks that aren't following those same procedures.

Melanie Avalon: Yeah, so I actually just pulled up the warning letter that you had found about that company because I wanted to see exactly what it had said. And this wasn't for their actual berberine, it was for the company in general but their manufacturing plant basically. And for example, this is direct from the FDA warning letter. It says, "Tree nut shells, peanut shell, corn, rodent feces, and seed foreign material were detected in their ashwagandha." "Tree nut shells, glass, hard plastic, and rodent feces were detected in their bilberry fruit." And there are a lot of other things as well. Scott, this is so shocking, so like ashwagandha that they're talking about, they had rodent feces in it as well as all of these allergens. If you go to their Amazon page, there ashwagandha has 506 ratings, 4.5 stars, it says that it's organic, it says it's free from gluten, dairy, and soy. The other pieces in this warning letter say that they found wheat in some of their other-- "Wait, wait, wait, sorry, I missed that." Wheat and rock were also found in their ashwagandha. So, "Ah", listeners, literally, so like you can go to Amazon and get this ashwagandha 506 ratings, 4.5 stars, it says "It's organic," it says "It's gluten, dairy and soy free." And when they tested this, when the FDA tested this, they found gluten, rat feces, and a myriad of other things. This is just so problematic. This is so problematic.

Scott Emmens: It is. I want to make the statement that I think this is the more rare companies, but it does happen, it does exist that you can have a GMP facility with great ratings and a decent brand name and still have-- I mean, I think those are pretty significant issues.

Melanie Avalon: And this isn't like some small-- like they have a lot of reviews on Amazon and a lot of products.

Scott Emmens: Correct? So, bigger doesn't mean better. What means better is, "Did you follow GMP and what is your track record with the FDA?" And we have an immaculate track record. And I think that speaks volumes. But the reason we have it is we just believe in following the procedure to make sure that like our families take our products, I take AvalonX products, I take MD Logic products, I give my family MD Logic products, I would never want to have skipped a process or a step. Because those processes are put in place for very good reasons. And most people aren't aware of those because they're not readily public-- it's not readily public information. But I think I remember I got a five shock emoji face from you when I sent you that link.

Melanie Avalon: Listeners, friends, do your due diligence when you choose the supplements that you choose to put in your body. We found a source that we felt really good about with the testing and we tested it for purity and potency. But then we wanted to go one step further because this was my first supplement that was an herb. My previous supplements have been serrapeptase and magnesium. We had the certification from the source that it was free of pesticides. But it was really, really important to me that we do third-party testing on that, just like we did the third-party testing for the purity and the potency because again it's an herb, it's being grown. That took a while because it took a while to find, what was the word like a company that would do the test?

Scott Emmens: It was a third-party laboratory that would do pesticide testing as well as other testing. But we chose at that point, we had all the other testing, we had done internal heavy metal testing twice, internal purity, internal identification and compliance, so at that point we really just wanted to make sure is this was pesticide-free by all the definitions that are set by the US Government and then some. And we set that out for a third-party pesticide test.

Melanie Avalon: Yes, and I'm so happy we found a company that we really like to do that and it came back all clean, all good. And I should tell them the nuance of it. Another reason it took so long to find a company is most of the companies would just give you a blanket, like a yes/no about whether or not it was below a certain level. But I wanted it to be quantified. [chuckles] I wanted to know if it was there, like how much was it there? It took a while to find a company that could work with us to do that, but we did. And we got the green light, it's all good, no pesticides.

Scott Emmens: It really is. And I'll tell you, I would not take any other berberine than this one based on the fact that we know the source is good. We've triple-tested it in-house for the four cores, which is purity, heavy metals, etc., identity, purity, strength, and potency. So, at this point, we feel like we've got a great berberine that's pesticide free, heavy metal free, toxin free, mold free at the right dosage, and in a glass bottle and on top of that with no stearates, palmitates, or other heavy chemical anticaking or filling agents. It's the purest best berberine I think that you're going to find in terms of literal testing and its final ingredients.

Melanie Avalon: I always have to ask you Scott, its filler and lubrication agent?

Scott Emmens: Yes. there are two things that people should be familiar with it. There's what they call lubrication or anticaking. Because when you put these products through these machines to put them in little tiny capsules, it requires some lubrication agent. And that's typically a magnesium stearate, silicon dioxide, or they'll call it silicon, which is silicon dioxide because that FDA allows you to say silicon versus silicon dioxide, little euphemism or a calcium palmitate. I'm okay, I take products with magnesium stearate. I don't think it's the end of the world. But if you're taking 15 capsules a day, you want to get it as pure as possible. And I think in this day and age, we're already exposed to so many things, we want to make sure that it's as clean as it can be. So yes, this product is free of magnesium stearates, that is an anti-caking agent which means it prevents it from blocking up the machines, which is also why we have to do small batches and why it's a little pricier because in order to shut down an entire line or have a dedicated line that has no lubricant or non-magnesium stearate/palmitate lubricant, you've got to have these smaller batches or a dedicated machine. And that's anti-caking. They're called lubricants and then there're fillers which are typically rice or cellulose or something else that you may or may not want. So typically, when we do a filler and we only do that when we have to whether that's an AvalonX product or MD Logic product, we use most benign possible filler there is which is methylcellulose, organic grown, human use, basically methylcellulose, which is like tree bark or fiber. And the only reason you do it is that the capsule doesn't shake loose. In other words, if the capsule size is-- you've got to get the capsule full, otherwise it's going to shake loose and the capsule doesn't feel right or fit right.

The anti-caking agents prevent the product from blocking up the machine, clogging up the machine, and keeping the product flowing into the capsules properly. But a lot of folks don't want magnesium stearate, hence why we go the extra mile to do two things which is A, use either no anti-caking or a natural anti-caking agent that is either beneficial for you or neutral or none. And then on the filler, we use either no filler or we use a filler that is methylcellulose or something super benign or beneficial rather than things like rice flour or other things that people can be allergic to.

Melanie Avalon: Yeah, so the berberine containing a very small amount of monolaurin, which is exciting because people will actually take monolaurin for its health benefits. But I don't like to emphasize it because it's not like-- it's barely in there. But yeah, so it's nice to have something that could be potentially beneficial in there as well.

Scott Emmens: And the monolaurin, in this case, would be the anti-caking agent. But to your point, some people take monolaurin as an actual supplement for health, for digestive health. And I think it pairs really well with berberine as I take it for digestive health in terms of its benefits.

Melanie Avalon: Yes. But I really want to emphasize, it's not like monolaurin is in there as a supplement like you're barely getting it. It's more just to point out that it's benign, like it's nontoxic.

Scott Emmens: Exactly, you're talking about a minuscule amount of monolaurin, so it's [unintelligible [01:28:27] supplementation of it. It's really just because this is either beneficial or neutral versus some people who feel that the stearates can be negative.

Melanie Avalon: Exactly, so yeah, I'm so excited because it's almost here. No, no, no, no when this releases it will have just launched. So friends, if you want to get this berberine we are having an amazing launch special that is through the holidays, through December 31 right like through the--

Scott Emmens: Correct, it starts on December 16 and goes all the way through the holidays through December 31. Perfect time for your January 1st New Year's resolutions and there's a tremendous discount that Melanie will have on her website. So, Melanie, I'll let you take it from there.

Melanie Avalon: During this launch special, you can get 15% off of one bottle or 25% which is amazing, off of two or more bottles. And that is just during the special and/or while supplies last. Stock up now. That we'll be at avalonx.us. Again, avalonx.us, 15% off of one bottle, 25% off of two or more bottles through the end of 2022. Beyond that, some other resources, if you want to stock up or get my other supplements, serrapeptase and magnesium, you can use the coupon code MELANIEAVALON that will get you 10% off or if you would like 20% off code, you can text AVALONX, just the word AVALONX, you will not believe how many people text, not AVALONX. They text like, they're like, "Hi, give me the 20% off code?" Like no, no, no that's not how this works, the computer can only read AVALONX.

Scott Emmens: It's a computer. Yes.

Melanie Avalon: It's a computer. So, text AVALONX To 877-861-8318 that will sign you up for text updates and will give you a 20% off code. You can also get email updates at avalonx.us/emaillist. And then both that 20% off code and the 10% off code MELANIEAVALON are also good at MD Logic Health, Scott's main company, they have an array of-- how many products do you have, Scott?

Scott Emmens: Right now, we have about 40-something skews and products. And we are probably going to have somewhere closer to 65 mid 2023, we got a very aggressive pipeline of either cutting-edge and/or newly formed versions of products that we feel like it would be beneficial.

Melanie Avalon: Yes, so that's super, super exciting. So, definitely check them out. I know one of the supplements we've talked about a lot on this show is your melatonin. I know people are really liking that one.

Scott Emmens: Fanfare for sure.

Melanie Avalon: Yeah, as well as Scott's collagen.

Scott Emmens: Thanks for mentioning both. The melatonin we reformulated by the way which is the exact same melatonin formulation, but we took out the rice and we took out-- I think it had a little mag stearate, so we removed that. So now that is an even more pure, more clean version of our Melatonin Max. And yes, our Marine Collagen is doing really well. People love it because you are getting 13 g of collagen plus you are getting what they call co-factors to create collagen or collagen synthesis in your body. People underestimate that part because you can take as much collagen as you want without vitamin C, manganese, zinc, vitamin A, and vitamin C. You cannot convert those amino acids into collagens. So, you can drink collagen all day, sort of making a cake with a ton of powder, but if you don’t use a little bit of sugar and butter, you are just going to have a giant flour cake.

Melanie Avalon: Yes, so I can guarantee you this collagen was Scott's baby, kind of like the way I am with my supplements. If you are looking for collagen supplement. This is the one that you want for sure. If you want to go through my site to get that, the link is melanieavalon.com/mdlogic and again the coupon code MELANIEAVALON will get you 10% off sitewide. As well as that 20% off coupon code that you by texting AVALONX To 877-861-8318. And again, stock up on berberine before the special ends.

Scott Emmens: Well Melanie, I've never been so excited for one of your launches as I am for berberine. I feel like your audience is going to love this. I feel like this is going to be a tremendous product for your fan base but most importantly, I think now having done three products with you and having had multiple discussions on your future products I feel like I need to assure your fans that you do not let a single thing go. Every single thing that goes into this product and does not go into this product. You have your eyes on, the research on, and I think together we are making a fantastic team and even more importantly great products that are really healthy and great for people and I couldn’t be more thrilled to launch berberine with you, so this is fantastic.

Melanie Avalon: I am just so thrilled and honored and excited and grateful as well. Listeners, working with Scott has been the dream partnership and I am just so grateful that I can finally do exactly what I wanted to do with the supplements and make them for myself and for everybody else, so I am so happy. Actually, this is a good way to end literally just right now Scott, you know how you were mentioning earlier the person at the CGM company who was sharing his experience on the podcast. He actually literally just emailed me because I had emailed him to tell him I was making a berberine. Would you like to hear what he said about berberine?

Scott Emmens: I would love to hear what he said. This is like serendipity.

Melanie Avalon: I know this is like in real life like real-time. [chuckles]

Scott Emmens: It's real-time and it's happening at the moment.

Melanie Avalon: Complete third party. All I did was I told him I was making a berberine supplement. So, he said, "Berberine is a great idea of all the supplements I've tested for glucose regulation, berberine has had the most significant impact and our internal staff experiments confirmed my anecdotal observations." One cool thing to test with berberine would be proper dosing. Most use berberine as a pre-prandial taking 500 to 1000 mg 20 minutes before meals. I tried that and it didn’t work for me." That's what he was saying, Scott. "A smaller camp including myself takes 500 mg twice daily morning and evening. While it did take a few weeks to see results, I saw an overall decrease in my own fasting glucose on that regimen." So that's a nice little testimonial and I think it really speaks to when you guys get your berberine you are going to need to find the way it works for you specifically.

Scott Emmens: That is a great way to end. I think that's serendipity.

Melanie Avalon: I think so. Well, this has been absolutely amazing and Scott you are going to have to come back for all of our future product launches. I hope you are down with that.

Scott Emmens: I can't wait. I look forward to any questions, comments from the fans. I'm starting to feel like a fan and a welcome member of the family of the IF Podcast. So, thank you so much for having me again, Melanie, I look forward to us speaking again.

Melanie Avalon: You too and this will have already happened, but have a Happy Thanksgiving.

Scott Emmens: That's right, you too.

Melanie Avalon: Bye.

Scott Emmens: Bye, bye.

Melanie Avalon: Thank you so much for listening to The Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Dec 11

Episode 295: Food Choices, Macros, Ketosis, Chronic Pain, Oxalates, Organ Meat, Variety In Fasting, Exercise, And More!

Intermittent Fasting


Welcome to Episode 295 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

BUTCHERBOX: Grass-Fed Beef, Organic Chicken, Heritage Pork, Wild-Caught Seafood: Nutrient-Rich, Raised Sustainably The Way Nature Intended, And Shipped Straight To Your Door! For A Limited Time Go To Butcherbox.com/ifpodcast And Get Free Ground Beef For LIFE Plus $20 off your first box!!

BEAUTY AND THE BROTH: Support Your Health With Delicious USDA Organic Beauty & The Broth Bone Broth! It's Shelf Stable With No Preservatives, And No Salt Added. Choose Grass Fed, Grass Finished Beef, Or Free Range, Antibiotic And Hormone-Free Chicken, or Their NEW Organic Vegan Mushroom Broth Concentrate! The Concentrated Packets Are 8x Stronger Than Any Cup Of Broth: Simply Reconstitute With 8 Ounces Of Hot Water. They’re Convenient To Take Anywhere On The Go, Especially Travel! Go To melanieavalon.com/broth To Get 15% Off Any Order With The Code MelanieAvalon!

FEALS: Feals makes CBD oil which satisfies ALL of Melanie's stringent criteria: it's premium, full spectrum, organic, tested, pure CBD in MCT oil! It's delivered directly to your doorstep. CBD supports the body's natural cannabinoid system, and can address an array of issues, from sleep to stress to chronic pain, and more! Go To feals.com/ifpodcast To Become A Member And Get 50% Off Your First Order, With Free Shipping!

To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get Free Ground Beef For LIFE Plus $20 Off Your First Box!!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz

Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

Go To cynthiathurlow.com/creatine and use code CYNTHIA for 10% off!

Episode 292: Creatine, Brain Health, Sex Hormones, Muscle Building, Insulin Sensitivity, Sarcopenia, Andropause, Mood, Motivation, BDNF, And More!

BEAUTY AND THE BROTH: Go To melanieavalon.com/broth To Get 15% Off Any Order With The Code MelanieAvalon!

Listener Q&A: Heather - IF

Listener Q&A: Robyn - Chronic Pain Flair

The Melanie Avalon Biohacking Podcast Episode #104 - Sally Norton (Oxalates)

The Melanie Avalon Biohacking Podcast Episode #153 - Bill Schindler

Ep. 238 Eat Like A Human: What Should We Eat? with Dr. Bill Schindler

Go to eatpluck.com an use the code CYNTHIA15 for 15% off!

FOOD SENSE GUIDEGet Melanie's App To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More!

Go to safecatch.com and use the coupon code for MELANIEAVALON for 20% off!

The Science, Nutrition, And Health Implications Of Conventional Vs. Sustainable, Grass-fed, Pastured, And Wild Meat And Seafood, Featuring My Honest Butcher Box Review!

FEALS: Go To feals.com/ifpodcast To Become A Member And Get 50% Off Your First Order, With Free Shipping!

Listener Q&A: Therese - Repetitive Routines Or Mix It Up?

Listener Q&A: James - Constantly Changing Fasting Windows

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 295 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time and get ready for The Intermittent Fasting Podcast.

Hi friends, I'm about to tell you how you can get free grass-fed, grass-finished beef for life plus $20 off, yes free grass-fed grass-finished ground beef for life plus $20 off. We are so, so honored to be sponsored by ButcherBox. They make it so, so easy to get high-quality humanely raised meat that you can trust. They deliver 100% grass-fed, grass-finished beef, free-range organic chicken, heritage-breed pork, that's really hard to find, by the way, and wild-caught sustainable and responsible seafood shipped directly to your door. When you become a member, you're joining a community focused on doing what's better for everyone. That includes caring about the lives of animals, the livelihoods of farmers, treating our planet with respect, and enjoying deliciously better meals together. There is a lot of confusion out there when it comes to transparency regarding raising practices, what is actually in our food, how animals are being treated. I did so much research on ButcherBox. You can actually check out my blog post all about it at melanieavalon.com/butcherbox. But I am so grateful for all of the information that I learned about their company. All of their beef is 100% grass-fed and grass-finished that's really hard to find and they work personally with all the farmers to truly support the regenerative agriculture system. I also did an interview with Robb Wolf on my show, The Melanie Avalon Biohacking Podcast, all about the massive importance of supporting regenerative agriculture for the sustainability of not only ourselves but the planet. This is so important to me. I'll put a link to that in the show notes. 

If you recently saw a documentary on Netflix called Seaspiracy, you might be a little bit nervous about eating seafood. Now, I understand why ButcherBox makes it so, so clear and important about how they work with the seafood industry. Everything is checked for transparency, for quality, and for sustainable raising practices you want their seafood. The value is incredible, the average cost is actually less than $6 per meal, and it's so easy. Everything ships directly to your door. I am a huge steak lover. Every time I go to restaurant, I usually order steak. Oh, my goodness, the ButcherBox steaks are amazing. I remember the first time I had one and I just thought, “This is honestly one of the best steaks I've ever had in my entire life.” On top of that, did you know that the fatty acid profile of grass-fed, grass-finished steaks is much healthier for you than conventional steaks? And their bacon, for example, is from pastured pork, and sugar and nitrate free. How hard is that to find? And ButcherBox has an incredible deal for our audience. For limited time, you can get free grass-fed grass-finished ground beef for life in every box of your subscription plus $20 off, yes, new members can get free grass-fed grass-finished ground beef for life plus $20 off when you go to butcherbox.com/ifpodcast, that's butcherbox.com/ifpodcast for free grass-fed grass-finished ground beef for life plus $20 off and we'll put all this information in the show notes.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. And then in our bodies, studies have shown they do things, like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years.

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means, when you put on some conventional lipstick, 30 years later, maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so, you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list, so definitely check it out. You can join me in my Facebook group Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you're thinking of making Clean Beauty and Safe Skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now back to the show.

Hi everybody and welcome. This is episode number 295 of The Intermittent Fasting Podcast. I'm Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, Melanie, how are you?

Melanie Avalon: I'm okay as you know. I honestly forgot what this is like to be super sleep deprived because I put a lot of effort into making sure that I get a lot of sleep, like I prioritize it like none other. So right now, I'm currently in the virtual queue for the Taylor Swift Presale Concert. And it's been five hours and I'm like not present. And I was texting Cynthia being like, I don't know if I'm going to be able to record but we are here. But I forgot what this feels like, I took some coffee.

Cynthia Thurlow: Good. So, a stimulant will definitely help you, but you're like a real person.

Melanie Avalon: I know. But I feel like I'm not quite present.

Cynthia Thurlow: Yes, but it's amazing how when you have like one blip in your sleep radar, you actually you'll be fine. You'll be tired, you'll go to bed probably around your normal time and then tomorrow you'll wake up and feel totally normal.

Melanie Avalon: So true, I don't normally-- I think we've talked about this. How much coffee do you drink? 

Cynthia Thurlow: Zero.

Melanie Avalon: Oh, none.

Cynthia Thurlow: Yeah, I'm not a coffee drinker. And it's funny because I had some genetic testing done and they actually said I do fine with, caffeine but I have to be completely transparent and say I made it through all my pre-med classes, all of undergrad and grad school never drinking coffee.

Melanie Avalon: With no coffee?

Cynthia Thurlow: No coffee. And the nights, I worked nights in ERs and worked overnights in the hospital and no coffee. I would drink, I can't limit this. I used to drink Diet Pepsi, which is disgusting.

Melanie Avalon: So, you weren't getting caffeine?

Cynthia Thurlow: But I couldn't tolerate it, it's not something I could drink every day. It was like, I would bring it with me in case I felt like I literally could not keep my eyes open but not every day. So, I'm officially very much an early bird that is uncaffeinated, except for my occasional green tea, which I don't necessarily have every day out of laziness.

Melanie Avalon: I was thinking about it actually a few days ago. Because normally I think I've shared this before I literally just have like a sip of coffee, like a sip every morning. It's more just a mental thing. It's probably like no caffeine in it at all. But I was reflecting their day on how nice it kind of is to not be dependent on coffee because I know and I mean I would go through, like in college really intense periods and coffee is something were-- like I did my experiment with alcohol and wine where I didn't drink for a year to see if I was like happier not drinking and I realized I was much happier having wine every night. Like with coffee, I feel like if I go into a coffee every day, I think I am happier without coffee, because it's just nice not to have to use it. And then when you need it, like right now, it's like very potent, and I probably just had like, a quarter of a cup and I'm like, okay.

Cynthia Thurlow: [laughs] But I think it's also recognizing that this is like a good indication of a day that you do well with it. Like, I will take adaptogenic herbs or I will take glandular products if I feel like I definitely need a little bit of support. But I don't, I like the way coffee smells. I just don't like the way it tastes, I never have and it's ironic that I have a child that's kind of an espresso Americano snob and really is into his coffee and then the other three of us don't drink it at all.

Melanie Avalon: Oh, wow. Yeah. I will say though my thoughts on coffee just in case people are curious because I'm not trying to scare people away from coffee. I feel like the studies are pretty consistent that coffee drinkers have health benefits.

Cynthia Thurlow: Well absolutely, the polyphenols and the plant-based compounds in coffee and bitter teas are, it's undeniable. I think that's how I actually started forcing myself to drink green tea a couple of days a week with a understanding that those bitter plant-based compounds actually have physiologic benefits. And so, I'm like, "Okay, you're going to learn how to drink this?" And so, I iced my green tea. That's how I drink it.

Melanie Avalon: It's also pretty mind blowing. I'm pretty sure they say isn't coffee our biggest source of magnesium? Am I making that up?

Cynthia Thurlow: I mean I think about getting a lot of those from brightly pigmented vegetables. And I think coffee is very bio-individual because I have some patients that will actually increase their cortisol, which increases their blood sugar. And so, it's figuring out what the right amount is for everyone. I used to have patients that would drink, I don't know, 10 cups of coffee a day. And I was like, how are you functioning? I would be a like nervous, jittery, mess.

Melanie Avalon: Yeah, I mean there's definitely that tolerance that happens. I shudder thinking about how much I drank in college. I don't know why I was thinking coffee was this high source of magnesium. But I think it is definitely like the number one source of something like polyphenols or something in Americans' diets, which is interesting.

Cynthia Thurlow: That is, I would hope it would come from a combination of things and not just something drinkable. But I think Americans just really, like I understand, I love the idea of something warm and my hands like the ritual of that I get, but I don't know, I like getting polyphenols from a variety of things, even bitter herbs and vegetables and things like that.

Melanie Avalon: I looked it up, it is antioxidants for most people. That's crazy.

Cynthia Thurlow: Well, think about how many people are drinking regular coffee as opposed to like understanding that it tends to be a mycotoxin-rich food product and just understanding that there're some nuances to the healthiest options that are out there. I'm probably going to get hate mail from the coffee lovers out there. But that's always the way I think about it. As I think if you tolerate coffee and you enjoy it, that's great. Just try to pick the best quality product that your budget permits.

Melanie Avalon: Yeah, I definitely think like you mentioned those mycotoxins are quite an issue. And then just one other comment about what you're mentioning about the sleep. I'm prepping right now to interview, Heather Moday, she wrote a book about the Immune System and Immunotypes, I think I mentioned it on a previous episode. And something that just stuck with me that she was talking about was sleep and she was saying how like out of all the lifestyle factors like diet, sleep, exercise, sleep is hands down the thing that can give you the fastest return on investment, but basically what you were just saying like with one night's sleep, you can see so many changes and improvements in so many biomarkers, compared to like diet where you have to like takes a little bit and exercise even so, yes, value your sleep is the point. So, anything new with you?

Cynthia Thurlow: Oh goodness, we are finalizing our plans for spring break. So that's been exciting. And every year I plan a spring break trip and no one knows what I've planned. And so, there were some requests at the end of last year they didn't want to go away for Christmas. I was like, "Okay, I got that." And so, we're doing something different. We are flying to Portugal and we'll be in two cities there and doing a variety of historical things and food tours and I'm excited.

Melanie Avalon: Awesome and how are things going with your creatine?

Cynthia Thurlow: Good, it's really exciting, we've got amazing feedback. And from my perspective, women having a better understanding of how it can improve both cognition and muscle health. And it was interesting, I was presenting a research article to some of my coaches today and I was telling them about the role of lowered levels of estrogen, how that impacts muscle protein synthesis, and why in those instances, it's even more important that we're taking exogenous, meaning creatine outside the body because our body-- women actually make 70% to 80% less creatine endogenously, inside the body, this gets exacerbated further heading into perimenopause and menopause. So, I was talking to them about how they were looking at two different groups in this randomized control trial. Women that were taking creatine and not doing any strength training versus women that were taking creatine and doing strength training. And there was no comparison in terms of the net improvement in muscle quality and muscle health. I think on a lot of different levels, what I've been loving is just having the conversation about the unique needs of women. And also identifying that men benefit from taking creatine as well. So, it's going really well, I'm very excited. I'm so appreciative that you encouraged me to create my own supplements.

Melanie Avalon: I'm so excited, I'm really excited as well to hear people's feedback after trying yours. And I just got my notification email that yours is coming, I can't wait to try it. So, I know I've asked you this a lot, "How do I take it, can I take it with food?"

Cynthia Thurlow: You can take it. Typically, what I've been doing is using it in a smoothie, but you can take it with food, you definitely don't want to take it in a fasted state. It's for one of those feeding windows in terms of getting the maximize benefits, but it's a white powder, it's easy to measure, that gives you a complete-- the scoop is for 3 grams. All the research has been done on 3 to 5 grams, 5 grams is I'd be leaning more into individuals that are vegetarian or vegan because their needs are actually increased by virtue of the fact they are not consuming animal-based protein. So yeah, it's super easy to take. It doesn't taste like anything, it blends really easily, thankfully, because I think we've all had powders that are chalky, and don't mix well with water and that's never a good thing.

Melanie Avalon: So, you said it doesn't taste like anything.

Cynthia Thurlow: Mm-hmm.

Melanie Avalon: Really like, nothing?

Cynthia Thurlow: Not to me. I've got this acute sense of taste, I think, which is why I don't like coffee, because it's just too-- I was one of those weird people, anything that I would say I would be like the taste tester a couple 100 years ago to determine if something was poisonous, because I have this crazy acute sense of taste and smell, which is not to my benefit having worked in healthcare for many years.

Melanie Avalon: Wow, oh, I can imagine. I'll probably take it like literally with my food. I'm super weird. I like to take supplements with food like I just eat them. And that's okay, like open capsules and like pour them on things. And like I would order quercetin powder and just like add to my food, I would order all these random things like milk thistle.

Cynthia Thurlow: Oh, you're very adventurous.

Melanie Avalon:  Well, very exciting, so how can people order?

Cynthia Thurlow: Yeah, so you would go to my website and the correct address should be-- www.cynthiathurlow.com/creatine is what it should be. There are all sorts of technological glitches that occur throughout this launch process, it's eliminated, little glitches that we don't think are a big deal and then you realize with coding, any little miss stroke of a key can make things not work properly.

Melanie Avalon: I know it's crazy. I remember when I launched serrapeptase the night before-- the day of because it was a midnight launch. We realized there was a glitch and they had to rebuild my entire website right up until, it was so stressful. Yeah, technology-- and I'm like right now I'm still in this Taylor Swift queue. I'm like staring at the thing. [laughs] 

Cynthia Thurlow: I'm really impressed with your dedication.

Melanie Avalon: I have got to get these tickets. The thing is when they come out, if you know about, you probably don't-- about this verified fan presale that Ticketmaster does?

Cynthia Thurlow: I do not.

Melanie Avalon: So, I learned about it with this, for the different artists they try to make it so that the fans can get tickets without it going through all of these resellers where they jack up the prices so they do this like a special sale where you have to be on their email list and then you have to apply and then you have to be accepted and it seems very arbitrary how they accept you or not. Like my good friend did not get accepted, but I did. So, then if you get accepted, then the day of which was this morning you get in the waitlist, and then you have a code for once you get in to like actually get the seats. But it's been so glitchy I think. Ticketmaster sort of crashed from all the Taylor Swift Fans. So, that's where I am waiting. But okay, sorry, tangents.

Cynthia Thurlow: No, that's super exciting. I'm excited for you.

Melanie Avalon: Last question about the creatine, is there a launch special or coupon code for people?

Cynthia Thurlow: It should be CYNTHIA, it we'll give you 10% off. During the launch we had even more amazing discounts, but now that it is officially on sale, you get 10% off with code CYNTHIA.

Melanie Avalon: Awesome, awesome, awesome. And last question about it. How is your creatine different from other creatines on the market?

Cynthia Thurlow: Well, I think we really did an incredibly conscientious effort to keep it simple, there were lots of ideas that were proposed. And I really wanted it to be creatine monohydrate and without any fillers, to know where it was properly sourced from. And I just think when you get online, and you buy things from Amazon as an example, obviously, there are great things that come from Amazon. But I think when it comes to supplementation, we just have to be careful. And so, we know where this product was sourced from, we know where it's packaged, we know what it's not full of. And I know much to your point about not having fillers and gluten and dairy and soy and other garbagy things that get added to supplements in an effort to keep costs low. This is what I believe to be the most high-quality creatine monohydrate that's available in the market.

Melanie Avalon: Awesome. Well, I can definitely attest to all of that just for listeners who are not familiar, both Cynthia and I work with MD Logic to create our supplements. And the amazing thing about it is the ability for us to really make exactly what we want to make to the highest quality and they test multiple times for heavy metals and toxins and fillers, and it's nice to feel very confident in the products that we're creating. So, I'm very excited for you and the creatine.

Cynthia Thurlow: Thank you. Likewise.

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Melanie Avalon: Shall we jump into some questions for today?

Cynthia Thurlow: Absolutely.

Melanie Avalon: To start things off, we have a question from Heather, the subject is "IF." Heather says, "Can you tell us, ladies, what a day of eating looks like for each of you? How much protein and carbs y'all eat and still are able to maintain ketosis? I'm about to receive all three books from both of you in the mail." This question is from actually a few years ago, she's probably talking about my book and then when Gin had two books. "I'm about to receive all three books from both of you in the mail, so, excited. I have been on keto way of eating for over a year and just starting to look into expanding my carb intake XOXO."

Cynthia Thurlow: Well, Heather, thank you for your question. I would say when I was first new to fasting, I didn't track my macros per se. But obviously, Dr. Gabrielle Lyon's work has had a huge influence on me. And so initially, after I met her, I started tracking protein and that's my guide. Now, I don't track macros because I generally don't need to and I just lean into more of an intuitive eating approach. As an example today, I didn't break my fast until gosh, almost 12:30, because I had to drive to DC with my husband for a doctor's appointment. And so, I sat down and had a bison burger, I had three deviled eggs, I had some sauteed mushrooms, a lot of this is just leftover stuff. And I would say that this is a lower-carb meal for me. I tend to hover under 75 grams, under 50 grams, sometimes as much as 100, but I definitely am conscientious and it's not that I don't enjoy carbohydrates. But even the non-starchy variety just depends on the day. And for me, it was eating a meal quickly because I had things I had to do this afternoon. And then my second meal today will probably be, I think we're going to boil some salmon. And I might have salad, we do a lot of food prep in my house just to make meals move along faster. Today is going to be a lower carb day. A higher carb day, I might have 100 to 125 grams of carbs. I just do better, me personally, when I keep my carb threshold about under 75, under 50 a day, but it's never to be restrictive. It's just I lean into what my body needs. Like yesterday, I needed some more carbohydrates, so I had some blueberries as dessert last night and some dark chocolate. But I think for each one of us, it's really determining what makes us feel good, and I definitely carb cycle. On a day when I have more carbohydrates, I may have three meals in my feeding window, open up my feeding window, and just have more discretionary carbs that might be sweet potato or root vegetables. But the protein piece for me is almost always at least 100 to 125 grams of protein a day. And that's really what I lean into. And then the fats as I need to like today I had olives, which I know that Melanie hates. But I love olives, they're like one of my favorite things. What about you, Melanie?

Melanie Avalon: Yes, so I actually really like this question for a few reasons. One, because people ask me a lot what I eat and I don't like to hardcore share because I'm so crazy. And also, I don't want people to eat what I'm eating because it's what I'm eating. But in any case, to answer this, I don't count protein or carbs, I sort of exist within a macronutrient paradigm. So basically, I just do either low fat, high carb, or low carb, higher fat, not really high fat, I don't ever really go like super crazy on the fat. But in general, I'm usually doing a low-fat, high-carb, high-protein approach. And I'm happy that she asked about still being able to maintain ketosis because I'm going to comment on that. I do the one meal a day for four hours or so every night and it is about a couple of pounds of meat and it's a couple of pounds of fruit. And I just looked up the fruit, I probably eat about 200 grams of carbs and fruit, which is a lot mostly from like blueberries. I used to do pineapple. But the thing I wanted to comment on is maintaining ketosis. I actually don't know if I'm going into ketosis during the fast or how deeply I am If so, I haven't measured ketones and forever. Like last time I was measuring ketones was probably back in like 2018. And interesting, I mean this isn't surprising, but I did find that when I was on the higher fat days especially if I added MCT oil, the ketones would go through the roof compared to not so much on the high carb. But what I want to point out is, you don't have to be in ketosis to burn fat. And I think a lot of people can get all the benefits of intermittent fasting without worrying so much about whether or not they're in ketosis during the fast. So yeah, I honestly don't even know if I'm getting into ketosis, but I am eating about probably 200 carbs every night. And who knows how many grams of protein, whatever is in a couple of pounds of meat?

Cynthia Thurlow: Well, I think the big thing is understanding we're all bio individuals. So, asking us is certainly a great question but by the same token understanding depending on how metabolically flexible you are, depending on your age, how much muscle mass you have, can really influence what your carbohydrate threshold is. And certainly, you don't want to be in ketosis 24/7. In fact, that's why I kicked myself out. That's why I actually alternate the amount of carbohydrates that I consume. And I know Ben Azadi and I talk about this quite a bit. If you don't know, Ben Azadi. He's amazing, a friend of mine who heads up the podcast Keto Kamp and has proliferative content around ketosis and ketones and things like this. And so, we want to vary what we're doing day to day and I think that's certainly important.

Melanie Avalon: Like because of this question, I said, at the beginning, I get so nervous about people thinking there's one answer that they have to do what another person is doing when bio-individuality is so key. I'm actually recording with Ben tomorrow.

Cynthia Thurlow: Oh, good, I love Ben.

Melanie Avalon: I've never met him, just through email. So, I haven't like talked to him or anything.

Cynthia Thurlow: No, he's one of the most positive people you will ever meet. Like really and genuinely one of the most positive people. And I mean, we've been friends for several years and have spoken on so many stages together. And my husband knows, he and his fiancé and I know them and, like we just really enjoy each other's company. He's a good person, a good human.

Melanie Avalon: I'm really, really excited about that. So okey-dokey. Shall we go on to our next question?

Cynthia Thurlow: Sure, this is from Robin and the subject is "Chronic pain flare." "I enjoy your podcast and I'm loving the diet. However, I'm having a significant flare-up of my chronic pain and wonder if it is related to intermittent fasting. I've been diagnosed with central sensitivity, chronic Lyme, and fibromyalgia. Is it possible there is another variable play? Always too many variables? My wife suggested I ask you. My internet search didn't yield any answers and I'm hoping you also haven't heard of this happening or if it does happen to some that it will subside as my body adjusts. I've been doing intermittent fasting since mid-April and vary between four to eight-hour windows with only occasional lapses when I've been sick. I really love it, so don't want to stop." Thank you.

Melanie Avalon: All right, Robin, thank you so much for your question. So, I thought a lot about this and I have a very casual answer. And then I have what I found from researching, which did not find the answers I was hardcore looking for. I'll start with the research side of things. So, I did a lot of searching for fasting and chronic pain. There's a lot of studies on fasting helping chronic pain. So, there was a really nice review. I think it was a review, but it was called Intermittent Fasting: Potential Utility in the Treatment of Chronic Pain across the Clinical Spectrum. I had never thought about pain, how it breaks down, like all the different types of pain. So, it talks about like all the different types of pain and like how there're six main types and has this really nice chart about how fasting can benefit most of those types with sources. But just in general if you do a search in PubMed or Google Scholar, there's a lot of studies about fasting benefiting pain, which is not the experience that Robin is sharing. I found another study called the analgesic effect of refeeding on acute and chronic inflammatory pain. And it was speaking to the effects specifically of fasting versus eating on pain perception. It was in rodents, not humans, but some of the interesting findings. So again, I don't know how much of this applies to humans because of the rodent aspect. But they did find that both fasting and feeding helped pain, but that for fasting in the rodents it was only in the second half of the fact that they started experiencing the pain-relieving effects and fasting helped only the inflammatory type of pain and not mechanical, whereas food seemed to help both. Again, that's nuanced I don't know how much of that applies to humans, especially when the majority of the studies that I could find were that fasting helped pain, my casual, non-scientific sort of N of 1 I haven't experienced it but I feel like I've seen all people talking about this, a lot of people will say that when they start fasting, whatever issues they have, can get worse before they get better. And I don't know if it's like a healing crisis or a detox effect or what's going on. I mean it does sound sort of like that rodent study where it said the pain-relieving effects started in the second half of the fast. So, have you heard that Cynthia, where people say that it gets a little bit worse before it gets better with fasting?

Cynthia Thurlow: It's funny, I always think about food-based sources of inflammation that can be exacerbated, especially with someone that has chronic Lyme, I think there's a lot to unpack there. I mean, you've got a chronic inflammatory response syndrome. And I can come at this question with many different angles. More often than not, people feel a whole lot better as they're pulling things out of their diet. I wonder if there's a diet variable that hasn't been examined that may be making things worse in conjunction with fasting.

Melanie Avalon: Yeah, I would encourage you, Robin, to keep on with the fasting, I would imagine there are other variables at play, and I can't see how the fasting would continually perpetually continue to make things worse. I would probably stick it out and see what happens and see if it gets better. And definitely, like Cynthia said, look at other potential issues for what might be going on there with food and things like that. Talking about, Cynthia, where like when people start fasting, they experience things. I don't know if it's because the body is like finally cleaning up and tackling stuff, but I feel like people will experience, I don't like using the word healing crisis because that sounds very woo-woo but do you know I'm talking about in this idea?

Cynthia Thurlow: I do, again, I'm going to come out this as a clinician, and from my perspective, if there's this upregulation of autophagy and there's some degree of deeper healing that's ongoing. And then on top of that their detoxification pathways aren't properly opened. I mean that could be contributory. I'm just looking at this as just from the perspective that we know, we detoxify every day, we poop, we pee, we breathe, we sweat. But the two main sites of detoxification where our body is getting rid of toxins, breaking down medications, etc., two phases that occur in the liver and then the bulk of toxins are then hopefully excreted through the digestive system and the gut. And so, I think there're many variables at play when people tell me that they're having an upregulation in pain, I believe that but obviously, I think that there's probably a component to this that is probably not completely clear in the question. And it's not a criticism of Robin, I'm just saying that chronic pain people just have an upregulation in inflammatory cytokines and other inflammatory processes. And there could be something else going on. When people tell me they have fibromyalgia and they have a tick-borne illness. There's a lot going on. From my perspective, I think it's digging deep, anti-inflammatory nutrition, removing the most common predicators of inflammation in the body, the gluten, grains, dairy, alcohol, sugar, soy in conjunction with fasting can be really powerful. But I would also want to ensure that Robin has taken the steps or is leaning into opening up those detoxification pathways that could be exacerbating why there's a pain response.

Melanie Avalon: Yeah, I think that's great. Another thing I was thinking of, this is not probably what's happening with her, but it's just an example of something where something might get worse before it gets better, people will talk about when they go on, like a carnivore diet, and they have oxalate dumping, things like that where some sort of restriction for whatever reason causes a release of a compound or toxins or a stir up of something else.

Cynthia Thurlow: This plant-based defenses are real thing. I think that for many of us, obviously if you have chronic Lyme, you've had multiple rounds of antibiotics. There's no question you've got some degree of hyperpermeability of the small intestine. There's a lot that can go on. So, from my perspective, those are the people who tend to be the most sensitive to those plant-based defenses, whether it's oxalates, whether it's saponins. There're just so many variables that could be impacting that. And I find that even those of us that are abiding by like a gluten-free diet, I always think about almonds as the best example like they're proliferative and keto and low-carb products. But the oxalates can be a huge hindrance to, really dampening down the inflammatory response in the body. And for a lot of people, they may get pain, others may get diarrhea, they may have abdominal pain. It's interesting I interviewed an oxalate expert on the podcast.

Melanie Avalon: Who'd you interview?

Cynthia Thurlow: Monique, and she trains underneath, who's that woman? It's like Sharon Sandy.

Melanie Avalon: Sally Norton and Susan Owens mixed up.

Cynthia Thurlow: Yes, it's one of the two. And so, she trained with her and she's in a wonderful resource and all her content is leaning in the oxalate. I was stunned at how much I learned. And so, for me, I don't tolerate a lot of the heavier oxalate foods and still don't to this day. And I think a lot of it had to do with the 13 days of being hospitalized, a lot of antifungals, antibiotics for six weeks, and my gut's probably still healing. So, when I look at this, there's a lot of different things that could be going on. But I would start with nutrition as being a huge driver in the detoxification.

Melanie Avalon: Yeah, I'll put a link in the show notes. I had Sally Norton on my show. The oxalate is one of those topics where I don't normally think about it and I think a lot of people don't normally think about it. But then like you just said, when you hear the information about it, it's mind-blowing. It's like, "Oh, maybe this actually is a major issue."

Cynthia Thurlow: Yeah. And I just had Bill Schindler on the podcast. I know you've had him on your podcast. We talked about oxalates and I said if you look at them under a microscope, they look like little crystals. And I said is it any surprise that these plant-based defenses are designed to protect the plant, but in someone who's susceptible to them, like me, this is why my mother, I've got an Italian mother, she's always trying to get me to eat more greens. And I finally had to say, I was like leave me alone about the kale and the spinach. I'm like it doesn't agree with me. And someone else, it's probably absolutely fine. But for me, I know exactly what it does to my digestive system. It just reminds me that, there's a very fine line with a little bit and then enough that will provoke a flare. And I'm just not willing to go there.

Melanie Avalon: Yeah. I'll also put a link in the show notes. My app Food Sense Guide has oxalates as one of the compounds that it shows if people are curious about the levels of oxalates in food. So, you can get that at melanieavalon.com/foodsenseguide and we can put a link to the interviews with Bill Schindler. He's so amazing.

Cynthia Thurlow: He was lovely and it was funny. I make my husband listen to my podcast episodes. He was like he's talking about bugs and he's talking about organ meat and he was like, "I got to meet this guy, he sounds amazing." And I said, "No he's a complete realist." Like, he'll tell you his kids didn't love the insects, but he talks about the value of cricket flour and just being open minded to the fact that back in paleolithic days you just ate what was available. You weren't picky about like I'm only eating muscle meat, I probably would have starved. But yeah, I'm not the most foodie adventurous, I'm not eating the cartilage and organs every day and goodness. I like Pluck though. Have you tried Pluck? 

Melanie Avalon: No, what is?

Cynthia Thurlow: So, it's like an organ meat-based seasoning. It's really good. We'll have to link it up in the show notes.

Melanie Avalon: Wait, that sounds so cool. Wait, it's made from organ meats, but it's a seasoning, wait.

Cynthia Thurlow: Oh, it's a chef that created it, James Berry, mm-hmm. I have had him on the podcast.

Melanie Avalon: Wait, this is so cool.

Cynthia Thurlow: Yeah, and it's really good. And actually, they came out with some new flavors. And so, the spicy is really good. Actually, I like all of them. But we'll link it up, we'll give you my discount code. But unlike anything that can get organ meats, in general, more accessible, to me if I throw it over deviled eggs, it's no big deal. But if I sat down and ate a piece of liver that probably wouldn't happen. So, I think the understanding is trying to make these things accessible. I know Bill does a great job with that. James Berry does a great job with that and he's a chef, and I just really appreciate people trying to find clever ways to get people eating more nutrient-dense foods.

Melanie Avalon: I'm looking this up. Okay, so like their main one, like the normal all-purpose one so it has a blend of liver, spleen, kidney, heart, pancreas with onion, salt, paprika, lemon, pepper, garlic, parsley, mustard seed, thyme. Wonder if they have one that's AIP friendly. Let's see pure. Let's look at the pure one.

Cynthia Thurlow: I think that's just organ meat.

Melanie Avalon: Okay, yeah. And then Zesty Garlic, let me look at that one. I like doing online shopping. Wait, this is so cool.

Cynthia Thurlow: Yeah, and they're really good. And so, James is like a real chef. And I love just how clever he is.

Melanie Avalon: Friends, I want the Zesty Garlic one, it has liver, spleen, kidney, heart, pancreas, and then onion, garlic, lemon peel, salt, carrot, garlic, cabbage, parsley, oregano, marjoram, basil, and thyme.

Cynthia Thurlow: Totally good. And spicy is good, too. We're kind of spicy people. We like a little bit of spice, my husband more so he does than I do. But it's going to be part of our holiday gift list because I think it's just a fun way to get people exposed to eating organ meat in a way that's not scary. Like I'm not going to sit down and eat a plate of spleen although I can respect those that do.

Melanie Avalon: Yeah, and they actually do list on their website if it's AIP or not. Super cool, that never occurred to me, that's smart. And then there's a lot of people like there's some company that makes, it's like breadcrumbs, but it's like made from meat. Do you know what I'm talking about?

Cynthia Thurlow: Oh, is that like the pork panko?

Melanie Avalon: Yeah, I think so. It's like they have it like chicken.

Cynthia Thurlow: Yeah, it's a little salty. I like the idea. We tried it and it was so salty. And I was like, I like salt but it was a little too salty for me.

Melanie Avalon: So, another company actually reached out to me called Safe Catch?

Cynthia Thurlow: Yeah, they reached out to me, I think I told you about the scallops with them.

Melanie Avalon: The scallops you told me about were-- because I read it down to look them up was Seatopia?

Cynthia Thurlow: Oh, they all run together.

Melanie Avalon: Seafood is my thing. So, I've been like taking notes. I literally have written down in my agenda to look up your Seatopia scallops. So, you like those?

Cynthia Thurlow: I thought they were good. I like to buy fish the day of-- that's my husband is a fisherman and likes to go deep sea fishing. And so, he's super picky about seafood. So, we tend to buy it the day that we're going to eat it. So, I think it's super convenient. Like I think ButcherBox is awesome in terms of like, meat shows up at my door, I don't have to go to the grocery store. I'm not 100% sold on seafood being sent to my house. I'm not there yet.

Melanie Avalon: So, I'll comment on the seafood aspect. Often times when you're buying it fresh, it's actually less fresh than frozen. Because frozen, they freeze it right there. And so that stops histamine production, and basically just freezes it in time compared to when you buy it at the store. If it hasn't been frozen in between which sometimes they freeze it and thaw it again. But regardless, it's a longer shelf life where it's been not frozen which is interesting. I think a lot of people don't think about that, which is why I'm all about the frozen. So, the Safe Catch, the reason I really, really like them is they have tuna and salmon and they test all of it for mercury. And I just think this is such a problem, especially with tuna because with tuna, there're so many different species and so many different sizes. So, the mercury levels in tuna can range, some tuna can be low mercury, but some can be really, really high. And so, they actually test, so all of their tuna test to be super low in mercury and the same with the salmon and it comes in, they just sent me a box, but it comes in pouches. So, I'm really, really excited that they reached out to me, they gave me a coupon code. So, this will only be through the end of the year. So, stock up now. And this would be a great thing to stock up on because like I said it comes in pouches. So, you can just stock up. You can get 20% off with the coupon code MELANIEAVALON. I'll put a link to that in the show notes. But their website is safecatch.com, which is easy. But yeah, going back to the fish thing because I'm like such a fish fan, you can always ask at the counter. Like if it's been frozen or not frozen or like what the deal is with it. Oftentimes, it's just a little fun fact at Whole Foods, half of the time this stuff that they have in the fish counter, is just a thawed version of the frozen bags that you would buy in the frozen section. Like they do with the shrimp. They do that with the barramundi, I think they might do it with the salmon. So, it's kind of crazy.

Cynthia Thurlow: Awesome. Now, it's always good to learn about options that are out there that are safer. I think after my mercury issue about five years ago, I've just been very conscientious about sporadically eating fish and not eating it often.

Melanie Avalon: Yeah, once you have that mercury toxicity problem and it's something where you can just stop me because I'm so passionate about this subject. I'll talk about it for an hour, but it's something where you don't see it, like you don't see the mercury in fish. So, if you could see the mercury, I promise you people would not be putting even moderate mercury species of fish into their mouth. I've said this a ton of times but if you look at like the spread and you take a piece of tilapia that has the lowest amount of mercury possible and you compare it to a piece of swordfish that has the highest amount, it can be 300 times. So, if you eat one piece of swordfish that could be like eating 300 pieces of tilapia for the mercury in one meal.

Cynthia Thurlow: My mom would throw a sea bass, like fixation for a long time.

Melanie Avalon: Chilean sea bass?

Cynthia Thurlow: Yeah.

Melanie Avalon: Oh, I know. It's so good.

Cynthia Thurlow: Yeah, and when I tell you it was like years. That's like every time we showed up, she went from being vegan to eating fish and eggs and we were very happy about this. And now she's back to eating meat. But the joke was, she would buy the most massive piece of sea bass and sea bass is wonderful, but it's like one of those overfished fishes that's why it's so expensive, that's the other thing is like trying to get acclimated, like being open to trying different things. I think that's important, just being open minded is certainly very helpful.

Melanie Avalon: Yeah, definitely. When it comes to the fish. I actually have a blog post, I'll put it in the show notes. I talk about the fish that I will eat because I really only will eat. I'm very, very limited. I'll eat scallops and shrimp because they're so low on the totem pole. I'll eat farm salmon, I won't even eat wild salmon with the exception of this Safe Catch, which is very exciting. And then I eat responsibly farmed tilapia if I know the source and then I'll eat Australia's barramundi and then when I go out, I might get like, sole or trout or something. It's funny Gin and I had completely different food tastes. So, she was like not about the fish at all. [chuckles]

Cynthia Thurlow: I grew up at the shore, for anyone that's from New Jersey, the shore, the Jersey Shore. And so, we had a lot of fish growing up. And it wasn't really until, probably until I got to Baltimore, because Baltimore's on the water and there's just a lot of like crabs. And I mean, you just eat a lot more shellfish and fish in general. And then I met my husband who's from Annapolis, and we don't eat a ton of fish because my kids don't love it. And it just isn't worth it, it's expensive. They like shrimp, so we do shrimp, but my husband and I will usually get fish for ourselves and then give the teenagers the meat, which is what they want.

Melanie Avalon: Yeah, it's interesting, that fish seems to be more of an acquired. "Oh, my queue is moving, okay, okay, I'm sorry, well, okay, okay. I might have to-- Oh, it's moving, I'm like 1,288 people in front of me.

Cynthia Thurlow: Oh my God.

Melanie Avalon: For the past five hours it's been at 2,000 plus and now it's just oh, 1125, I'm going to get in in a second. Okay, okay, I will just say about the fish. Sorry, this is real-time, real-time Melanie getting her Taylor Swift tickets. 950, I'm going to have to jump it a second, 762. I'll just say about the fish really quickly. It's interesting that it seems to often be an acquired taste. I feel like kids shy away from it. 

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Melanie Avalon: Okie-Dokie, shall we go on to another question?

Cynthia Thurlow: Yes.

Melanie Avalon: So, we actually have two questions and they go together, sort of, they're similar topics, so I thought I would read them together. So, we have a question from Therese. The subject is "Repetitive routines or mix it up." And Therese says, "Hi, love your podcast." I recently started IF and the first weeks, I simply followed the 16:8 method. I found an app that has great programs and found a program for weight loss and the setup seems to be switching it up with different intervals of eating and fasting. I think of it almost as when you exercise you get best results when you switch it up by doing both cardio strength and different types of intervals. Does weight loss via IF get better results when you're not letting your body get used to a steady rhythm, but rather surprise it with different internal windows of fasting and eating." And then James, his subject is "Constantly changing fasting windows," and he says, "I started IF about a month ago using the BodyFast app, which recommends a different program every week, 24-hour fast 16:8, 20:4 and everything in between to prevent your body getting used to a pattern. I also move fasting periods myself to allow social occasions. I have heard you talk positively about keeping the same fasting rhythm. What is your view on switching schedules in these ways?"

Cynthia Thurlow: Well, Therese and James, if you are at all familiar with my work, I am a huge proponent of variety as it pertains to nutrition, exercise, and a fasting program. Obviously, for women that are still menstruating there are times in the menstrual cycle when we should lean into more fasting as opposed to others when we should not. Men and menopausal women have the advantage of not having as much hormonal fluctuation. I typically do recommend-- our bodies get lazy, if we are doing the same thing, think about if you did the same workout at the gym every time you went, over time your body gets acclimated and you're no longer challenging it. And so, we want to think about exercise and a fasting regimen is a form of hormesis, beneficial stress in the right amount at the right time to keep things changed and challenged. And I'm absolutely a proponent of different types of exercise, which includes strength training, high-intensity interval training if that's appropriate for you, NEAT, which is just being physically active throughout the day that's not structured exercise. And then, leaning into the fasting piece. In fact, I was listening to a video of Chris Kresser today and he was presenting some new research, looking at women in particular in fasting and a lot of it goes back to things that I talk about, you have to have a large enough window to get enough protein in in your feeding window, not having to narrow the window, getting concerned with over fasting losing muscle mass. And so, there's a fine line for each one of us. And for me personally and I'm just going to use myself as an example, I'm in a very healthy weight, I don't want to lose muscle mass. I don't do long fasts. There are people to do them and if you have a lot of weight to lose, you're struggling a bit maybe you needed to have like a digestive reset, you have more latitude with that than someone that's already at a goal weight or already pretty metabolically flexible. I think it's a very individual decision, but I'm absolutely a fan of varying what we eat, when we eat, and not doing the same types of exercise every day. What do you think, Melanie?

Melanie Avalon: Yeah, so I've thought about this a lot in general, with the exercise and everything, I definitely agree that mixing it up is so key including all those different types, like you were saying, because that's really most in line with how we would have evolved as a species, we weren't going to the gym and like working out for 30 minutes every day or like doing the same thing every single day, and we were moving functionally, we weren't just exercising this one muscle to, really aesthetically the way it looks. So, health-wise, exercise, mixing it up, I think is great. With fasting, I think as well, it can be great to mix things up. But I think the complicated nuance is, because I just know how I personally am, which for me, like it really works following the same fasting schedule. And when I go off of it, I don't feel as well. And I think part of that might have to do with the peripheral clocks of our body are driven independent within themselves. I was actually just reading about this in a book that I'll probably talk about next episode because have you heard of-- I think I mentioned it before, it's the Oldest Cure in the World?

Cynthia Thurlow: No, I have not.

Melanie Avalon: It's by Steve Hendricks, it came out September 6 and it's the deepest dive into the history of fasting I have ever read. So, the subtitle is Adventures in the Art and Science of Fasting. I'm going to interview him which is really exciting, but its mind blowing some of the things I've been learning. But in any case, that part I was reading last night was about the SCN. So, the master clock in our body, which light affects and which drives a lot of our circadian rhythms. But then all of our cells have peripheral clocks and they can function on their own. So, they can be informed by the SCN, but they can also be completely informed on their own. And so, eating is actually a very intense clock within us and it's on its own rhythm and it's often based on how we're eating. And so, the reason I'm bringing this up is I find for me personally that if I follow my same fasting window of a one-meal-a-day situation at night, then I feel good during the day, I'm not hungry during the day, I'm hungry at night. I feel good at night, I find it that when I break it, it messes with that clock for me, and I just get ravenous. So, like if I were to like widen my eating window, which works really well for a lot of people like to have those days where they have a longer window. For me it like just doesn't work, it would just make me hungry and miserable and not feeling good. And so, I wonder if with the fasting it's something where people really should take it individually for how it affects them. And, how do they do with mixing it up or not mixing it up? I think some people will do better with mixing it up and some people won't. Do you have thoughts on that concept?

Cynthia Thurlow: I mean, I do. I just think overall if the bulk of the population here in the United States is not metabolically flexible, they have to change things up. I see where you and I are both coming from, honoring our bio-individuality, honoring the fact that I always call you the unicorn. And I mean that in the most affectionate way, like manner, not in a pejorative way. But like, I can get up early, I have to go to bed early, you can stay up late, you like to sleep in. So, it's like figuring out what works for our bodies. But knowing that the bulk of people are metabolically inflexible here in the United States and most westernized countries, changing things up in some capacity, even if it's, you lift an extra day that week, or maybe you go an extra hour without eating or maybe you shorten your window, like some degree of flexibility I think is important for us. And that's what I feel like intrinsically. And certainly, after coaching 1000s of people through this process, there are always exceptions, so let me be very clear. But I feel like most of us need some degree of alteration in schedule. Today's a good example, over the last several months, I've been leaning into eating a little earlier in the day and closing my window a little earlier and that has worked really well for me. But today, I didn't eat till I came home. So, I had an unintended almost 20-hour fast. And that's not my norm. But I was like, I'll be totally fine. I had a big meal, I'll have one more smaller meal before I go to bed, and I'll be good. Unfortunately, when I trained 1000 years ago, the mindset and methodology was you treat every patient the same in terms of if they have blood pressure problems, everyone starts with this medication at this dose. And I've just learned to be a little more thoughtful and a little more individualized. So, some type of variation of what you're doing it doesn't have to be dramatic, can be very helpful.

Melanie Avalon: I'm really glad you said that nuance and that's something I was actually going to comment on. I wasn't quite sure how to say it and I think you said it really well. So, for me, the way I would bring in variability in a way or switching things up would be like fasting a little bit longer. Like it would be like a slight tweak rather than just a completely different eating window or I think I could get similar benefits possibly by changing completely what I'm eating in my eating window, like, be it macro wise or whatever. So, or even like a low-protein day just to like switch things up, or switching to a low-carb day to switch things up. I definitely think there is some magic there with the metabolic [unintelligible [01:03:13] piece. I do wonder though if for some people just sticking it out, at least while they're metabolically inflexible to a certain window might be important until they're metabolically flexible. I don't know if I'm articulating it correctly.

Cynthia Thurlow: No, no, no, I totally agree with you and in fact, I had someone on Instagram the other day. And I know of her, she's very thin, she's an exercise person. She kept saying I don't know why you don't just tell people to intuitively eat. And I said that works fine if you're metabolically flexible, but if you are not, you can't and to think that everyone can is pejorative. And so, I have to very politely say that every time because she always comes back and says, "Don't tell women over the age of 50 they can't do this and this and this." And I'm like, "Well, maybe you're an outlier." But generally speaking, I'm trying to come from a place of kindness, but it's clearly a triggering topic. I think what I hear you saying is very aligned with what I think that we have to be gentle and kind and realize that some people are ready to jump in feet first and some people have to like dip their toe in the pond. They're terrified of adjusting what they're doing and so just acknowledge what resonates for you what feels good. We would never advocate that people do something that's beyond their comfort level. Like if you said to me, I want you to play to organ meat, I would struggle with that I have to be completely upfront, it might be just as scary as suggesting someone to change their feeding window. So, I think just entertaining the possibility of making subtle adjustments can be beneficial.

Melanie Avalon: Yeah, I cannot agree more and it's really glad to hear your thoughts about that. I often wonder, especially in the beginning when people are fasting if they hadn't flexed their fasting muscle yet, they might want to switch things up, but it's because they haven't stuck to it long enough to really get in the flow of fasting. So, I get nervous about people trying to be too intuitive, too soon. Some people are great though being intuitive, but some people aren't. You just have to know who you are and what works for you.

Cynthia Thurlow: Yeah, unfortunately, I sometimes see very metabolically flexible people shaming other people for not leaning into intuitive eating. I'm like, they can't it's not that they don't want to, the hormonal regulation in their body is off and they just can't lean into that. So, I think that we have to be kind and open minded and compassionate, I think that goes a long way.

Melanie Avalon: Exactly, even for me, it would be really, really hard. And it's not a skill that I feel like I need to learn. I don't feel like I need to be able to intuitively eat a brownie. Maybe if I eat a brownie that makes me really cravy and want more food and maybe that's just the way it is. And maybe I can just know that about myself and not feel bad that I can't, moderate things like that. I think it should be okay if you know that certain foods are troublesome for you to abstain if that makes you happier.

Cynthia Thurlow: Yeah, no, no I think it's interesting. The thing that I'm always intuitive about is carbs, I don't count carbs, but I have a good sense of how much I'm eating. And so, like yesterday is a good example, I wanted blueberries. And by some miracle, my 15-year-old hadn't eaten them all yet. My husband bought them on Sunday. And usually, he finishes off any fruits that's in the house within 24 hours. And so, I had some blueberries and my husband was like, I'm actually glad to see you eating some blueberries. I said, "Well, I wanted them." And it was like, my body wanted something healthy, and I'll lean into that. And so that's the intuition. But I acknowledge that not every person and quite frankly if we look at statistics 7% to 8% of Americans are metabolically flexible. So, the average person can't do that. I think it can be validating to hear that and also gives people something to work towards.

Melanie Avalon: All righty. Well, this has been absolutely wonderful. So, a few things for listeners before we go. If you would like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. The show notes for today's episode will be at ifpodcast.com/episode295. You can follow us on Instagram. I am @melanieavalon, Cynthia is @cynthia_thurlow_ and I want to apologize to you, Cynthia, for my craziness today and to the audience for my craziness, but I have the Taylor Swift tickets now. [chuckles]

Cynthia Thurlow: Yeah, so you got your tickets. I was saying to Melanie, the ticket prices have gotten so insane. I was like how do young people afford to go. I went to so many concerts when I was a teenager and a 20-something, kind of makes me sad.

Melanie Avalon: I know. It's crazy.

Cynthia Thurlow: That's probably why I have tinnitus. I have chronic tinnitus, a chronic ringing in my ears, and my working hypothesis from my ENT, it's all those concerts you went to and I was like probably Red Hot Chili Peppers was especially loud many years ago.

Melanie Avalon: Oh, I bet. So, we're going to like rock and roll-type concerts?

Cynthia Thurlow: I've been to everything. It runs the gamut from alternative music when I was in college is now considered very mainstream. But I've seen Red Hot Chili Peppers, I've seen U2 multiple times. I'm dating myself, but yeah, but now it's like I have no interest in being in a big loud crowd. I'm like okay I can watch everything online, I'm good. [laughs]

Melanie Avalon: Well, I go to concerts. I'm going to Mannheim Steamroller in a few weeks and I'm going to Trans-Siberian Orchestra, but I don't normally-- and I go to musicals that doesn't count. [laughs] I know I'm not a concert person except for Taylor Swift.

Cynthia Thurlow: Well, I'm very excited for you.

Melanie Avalon: So "Oh, my goodness." Okay. Well. This has been wonderful. Thank you again, sorry again, and I will talk to you next week.

Cynthia Thurlow: Sounds good.

Melanie Avalon: Bye.

Thank you so much for listening to The Intermittent Fasting Podcast. Please remember everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Dec 04

Episode 294: Creatine, Excess Skin, Toning Up, Clean Hair Dye, Hormones, Caffeine, Cortisol, Hormetic Stress, Jet Lag, Hydration, Melatonin, And More!

Intermittent Fasting

Welcome to Episode 294 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

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SHOW NOTES

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Episode 292: Creatine, Brain Health, Sex Hormones, Muscle Building, Insulin Sensitivity, Sarcopenia, Andropause, Mood, Motivation, BDNF, And More!

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Listener Q&A: Dillon - Too “Skin'ny"

Listener Q&A: Sarah - Toning Up

Listener Q&A: Marili - Hair dyes

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The Melanie Avalon Biohacking Podcast Episode #148 - Dr. Michael Breus (Part 2)

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The Melanie Avalon Biohacking Podcast Episode # 3 - Dr. Kirk Parsley

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Ep. 233 How to Optimize Your Hormones & Metabolism For Vitality

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 294 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time and get ready for The Intermittent Fasting Podcast.

Hi friends, I am so thrilled to announce that my next AvalonX supplement is official and almost here. It is something that I currently take every single day of my life and that is berberine. I first started taking berberine when I first started using a continuous glucose monitor which constantly monitored my blood sugar levels, I found that taking berberine had a dramatic effect on my fasting and post-meal blood sugar levels. Berberine is a plant alkaloid which has been shown to rival metformin when it comes to reducing blood sugar levels without any of the side effects. Blood sugar regulation is so important for health. It's a key factor in metabolic syndrome and preventatively taking care of your blood sugar levels or treating high blood sugar levels is so, so important for health and longevity. That's why I am thrilled to be making a berberine supplement. And it's not just blood sugar control, berberine has been shown to have so many benefits. It's been shown in studies to beneficially modulate adipose tissue. It can actually help change the composition of your fat to a more healthy profile. Think less visceral fat, which is the inflammatory fat found around our organs. It's also been shown to have beneficial effects on PCOS and reductions in inflammation and is a potent stimulator of autophagy which is one of our favorite things. Berberine has also been shown to have a beneficial effect on blood lipids, which is huge, and I wanted to make the best berberine on the market, we looked so hard to find a source of Berberine that tested to be high potency and free of pesticides. Yes, we did third party lab testing on our source as well as testing to assure its quality. It has been tested multiple times for toxins including heavy metals and mold and has no problematic fillers. It also comes in a glass bottle to help prevent leaching of plastics into ourselves and the environment. This is the berberine that you want I promise and it is coming at midnight of Friday, December 16. To get all of the updates about it definitely get on my email list that's at avalonx.us/emaillist, we'll be announcing the launch special on that list. You can also get text updates and a 20% off coupon by texting AVALONX to 877-861-8318. That's AVALONX to 877-861-8318.

By the way, if you would like to get a CGM to monitor your blood sugar levels and see just how berberine is affecting it, you can get $30 off NutriSense CGM at nutrisense.io/ifpodcast with the coupon code IFPODCAST, that's nutrisense.io/ifpodcast with a coupon code IFPODCAST. If you'd to get any of my other amazing supplements at avalonx.us, use the coupon code MELANIEAVALON to get 10% off sitewide at avalonx.us. You can also use that coupon code MELANIEAVALON to get 10% off sitewide and my fantastic partner MD Logic Health for that go to melanieavalon.com/mdlogic.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. And then in our bodies, studies have shown they do things, like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years. 

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo, and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. Also make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out. You can join me in my Facebook Group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you're thinking of making Clean Beauty and Safe Skincare a part of your future we have, we definitely recommend becoming a Band of Beauty member. It's sort of Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now back to the show.

Hi, everybody and welcome. This is episode number 294 of The Intermittent Fasting Podcast. I'm Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, Melanie.

Melanie Avalon: How are you, Cynthia?

Cynthia Thurlow: I'm doing well. I'm super excited. We're a couple of weeks into the creatine and we're getting such great feedback. It's really exciting. And I have to thank you for encouraging me to do my own supplements as opposed to white labeling supplements as I had been doing.

Melanie Avalon: I'm so excited for you. By the time this airs, it will have come out right? This airs December 5th.

Cynthia Thurlow: Correct.

Melanie Avalon: So, just as a recap, why did you choose creatine as your first supplement?

Cynthia Thurlow: I think it had a lot to do with the fact that I was getting more involved in the research. I myself over the last year started taking creatine last fall and was noticing a lot of beneficial gains in the gym, every week increased the amount of weight I was lifting. And that's been really important to me because I psychologically like to know that I'm getting stronger, not weaker with age. And we understand the complex in relationship between how we start losing muscle mass, and frankly bone mass in our 40s. It's really important to help maintain that. My thought process was I want all my supplements to be focused on two key areas. One is maintaining muscle mass and number two is anything that's going to be helpful for supporting brain and cognition. Creatine was an easy first start because both men and women benefit from taking creatine, but in particular, really my life's work is really helping women understand how it can benefit them. And I think there's a lot of common misconceptions, but it's probably one of the most well researched ergogenic aids or supplements that's out there and I just like people to understand how it can benefit them and not just about the muscle piece, but understand there are certain times during our menstrual cycle where our creatine needs go up and why vegetarians or vegans actually need more creatine than the rest of us. And taking into account the changes in physiology as we get older. For all those reasons, I decided that I would keep it pretty simple. I think you and I are in alignment that we'd like to keep the supplements simple so that we know what works or what doesn't work. And so, creatine all by itself seemed to be a good starting point.

Melanie Avalon: It's interesting because it's something that wasn't really hardcore on my radar or I think maybe I was sort of writing it off in my mind, because I associated it with a protein supplement, probably erroneously. And I was like "I don't need to take any protein-related stuff." But I'm realizing more and more how it's not really about that, as all of these other benefits and I've been hearing it pop up on so many places, so many books, podcasts. So, I'm really, really excited to get yours. We were mentioning the vegan thing, there's that one I would say famous, I realized I probably think things are famous that aren't famous. But there's that one well-known study that looks at creatine supplementation in vegans versus omnivores. And it's debated because they try to debate the interpretation of the results. But me reading it, I think it makes a strong case that vegans likely are, needing creatine to have better brain function compared to meat eaters. What makes your creatine special?

Cynthia Thurlow: Well, we really went to the research and it's creatine monohydrate. So, it's a pure form of creatine without fillers, there's no concerns about contaminants. I think the high-quality nature of it, I always jokingly say that you have to be careful where you buy your supplements and who you buy them from. And I just felt that MD Logic was the right company to partner with so that I could get the quality of supplements that I was looking for. But creatine monohydrate is the form of creatine that's best studied. And something that's important for people to understand is that you can't get enough of it from your diet, and just like everything else, we make less of it as we get older. I think for a lot of people, we made the association at the gym bro thing, you think about people that are using anabolic steroids. I just remind individuals that the amount that we're recommending based on the research is much smaller than what bodybuilders are using. It's not as if you're going to get puffy or start retaining water that's not going to happen because we're using therapeutic amounts as opposed to super therapeutic amounts that are used in that population of individuals.

Melanie Avalon: Yeah, I'm glad you mentioned that. I think that was one of the main associations I had in my head, which is why I was miss categorizing it and its potential benefits. And I know I can also speak because I know you're working with MD Logic. So, it's going to be tested multiple times for purity and potency, and for toxins and heavy metals and mold, which is, that's really important to me. How can people get your creatine and you have code for listeners?

Cynthia Thurlow: Yes, the code is CYNTHIA to get 10% off. You can go to cynthiathurlow.com/new-shop/creatine/ and that will get you direct access to a really interesting page of information. And you can use code CYNTHIA to get 10% off and we'll make sure we put that in the show notes.

Melanie Avalon: Awesome. Okie Dokie. So, we will put all of that in the show notes. I do want to share just I mentioned I was going to share something last week. I wanted to share it really quickly because I know with the timing of this, and the holidays for two reasons, all the food festivities coming up and also, I know people are looking for gifts and I think this would be the most amazing gift ever. I have something in my life now that I am obsessed with. I'm beyond obsessed. Do you have a composter?

Cynthia Thurlow: I do not. We weren't allowed to have them in our last neighborhood outside.

Melanie Avalon: So, a brand actually reached out to us wanting to partner with IF Podcast, so I'm hoping we can partner with them in the new year. We were booked with inventory for this year, but I did book them for my other show and it's Lomi. It's a composter that you can have in your kitchen. Friends. Oh, my goodness. I've been wanting to compost for so long, but it seemed very daunting. It just seemed like a big task. I have been throwing away as you guys know, I eat so many cucumbers. I throw away pounds of cucumber peels every night. And now I put all of my cucumber peels and all of my cilantro stems into this wonderful little device. It's like if you think of a crockpot, it's probably the size of two crockpots. But it's very sleek and savvy and quiet and I just have it down on the floor next to my trashcan. I throw all of my scraps in it every single night. I press the button, it runs overnight, and the next morning, it's magically turned into dirt. It is the most incredible thing. And you can put in these little pellets that will make it more microbial-rich dirt if you want to use that dirt to put in the garden or grow stuff yourself. I don't I just actually throw out the actual dirt. But it's becoming one of my favorite things. And I'm so happy it's in my life with all of the waste coming up off the holidays and are looking for a gift. This would be an amazing gift for people. I wanted to share it for so long because I've been so obsessed. So, now's the time, hopefully we'll have a code for them on the show in the new year. But for now, if you go to lowmi.com/melanieavalon, the coupon code MELANIEAVALON will get you $50 off. So, definitely check it out. It's honestly one of my favorite things.

Cynthia Thurlow: That's so awesome, yeah, our last HOA was really strict and so even the crunchy people in our neighborhood couldn't have composters, just silly to me. But maybe this will force me to revisit the concept because I have a husband who likes to garden. That's his thing, he loves planting fruits and vegetables and loves being out in the yard and doing yard work, and maybe that will encourage him to make good use of things that otherwise get tossed or put down the garbage disposal.

Melanie Avalon: Yes, you have it inside. You have it in your kitchen, so anybody can really have it. It's just so cool, the first time you do it too if you haven't done it before, though it's so cool to put in all of these food scraps, and then it's just this nice dirt in the morning and the dirt, it smells really good. It's fruity-smelling dirt for me at least because it's the cucumbers. And yeah, definitely check that out.

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Robb Wolf, who as you guys know is my hero in the holistic health world, worked with the guys at Ketogains to get the exact formulation for electrolyte supplements to formulate LMNT Recharge, so you can maintain ketosis and feel your best. LMNT Recharge has no sugar, no coloring, no artificial ingredients, no junk. They're used by three Navy SEALs teams, they are the official hydration partner to Team USA weightlifting, they're used by multiple NFL teams, and so much more. We have an incredible offer just for our listeners. You can get a free LMNT sample pack that includes all eight flavors. Citrus, watermelon, orange, raspberry, mango chili, lemon, habanero, chocolate, and raw unflavored and the raw unflavored by the way is clean fast friendly, You can try them all completely free when you make a purchase at our link, drinklmnt.com/ifpodcast. You can get this offer as a first time and as a returning LMNT customer. I know there are a lot of returning LMNT customers. The feedback I hear from you guys, "Loving LMNT" is amazing. LMNT offers no questions asked about refunds on all orders. You won't even have to send it back. And this offer is exclusively available only through VIP LMNT partners. You won't find this offer publicly anywhere else. So, again, the link is drinklmnt.com/ifpodcast. And of course, you better hurry if you want to get LMNTs limited-time holiday chocolate medley and we'll put all this information in the show notes. All right now back to the show.

Melanie Avalon: Okei dokei, shall we get into some listener questions for today?

Cynthia Thurlow: Absolutely.

Melanie Avalon: To start things off, we have two questions. I'm going to read both of them because they speak to a similar concept and it's something that we've talked about on the show before. But I really wanted to get Cynthia's input on this and see what she has experienced with her patients. So, the first question comes from Dylan, the subject is "Too "skin"ny." Hey, ladies love the podcast, I started listening in the middle of January this year when I started my IF journey. And I've since caught up and listened to every episode, you're both so funny and encouraging. I'm typically on a 24 routine but often find that I eat all of my food within one to two hours and I feel satisfied. I also do a 44-hour fast once every other week. Since January, I've lost over 50 pounds and have 10 more to go, but I'm at my target weight. I started at 235 pounds, the heaviest I've ever been. I'm also happy with the fact that I'm gaining muscle about as quickly as I'm burning fat by doing occasional HIIT and light weightlifting.

My question is regarding extra skin. I've lost weight so rapidly that I have a lot of extra skin, especially in my abdominal area. Will my body eventually begin to shed the extra skin through autophagy? Do you have any tips for reducing stretch marks without expensive creams or lotions? Any tips regarding this will be greatly appreciated. Keep up the great work. I recommended your podcast to several friends and coworkers and a few of them have started their own IF journeys. One of those converts is a friend of mine who is beginning his residency to become a physician. And by researching several papers and studies is now a major advocate for fasting. Regards, Dylan. First of all, I'm going to say, Dylan, that's awesome about sharing it with doctors because it's really nice to get some of this perspective into the mainstream medical community.

And we have a question from Sarah, the subject is "Toning up." Sarah says, "I've been doing IF around six weeks and I've just been introduced to your podcast, which I'm listening to on catch-up. So, apologies if my question is answered in a podcast that I haven't reached yet. I am doing IF for weight loss and anything extra from clean fasting is a bonus. With large weight loss comes saggy skin, will I have help with this over time or will I need additional exercises to target this? Loving the podcasts. All right, so Cynthia, have you had experience with this?

Cynthia Thurlow: Yes, so thank you to Dylan and Sarah for your questions. And yes, they are very similar in terms of people that have lost quite a bit of weight and are looking to have some improvement in the excess skin. One thing that I say to patients is in many ways when your skin stretches out, it's been stretched out for a period of time, depending on how old you are, obviously if you're a perimenopausal, menopausal it's going to be harder because as we're losing estrogen that is critically important for collagen and elastin formation. That doesn't mean it's impossible but I do find when people have lost large amounts of weight that sometimes it becomes more challenging. Now there are specific types of lasers, there are topical products that can help to some degree. But I would be remiss if I were to say that I think all of that can be ameliorated just with weight loss and fasting. But I think it really comes down to what bothers you and how aggressively you want to fix it.

I'm an advocate of people feeling comfortable in their bodies and feeling comfortable with where they are, but probably if you're feeling doing laser to help stimulate more collagen and elastin and if that's not something that's going to fix the problem or topical things are not going to be aggressive enough, then you could potentially move on to surgical interventions. And obviously, I'm not a plastic surgeon and I can't speak for them. But for a lot of my patients, they end up getting to a point where they want to surgically address this, I have just as many that are comfortable doing nonsurgical options as an aside, but as you are getting more to your ideal weights, there will be some changes to the skin, but a lot of it can be mitigated by, where we are in time and space, obviously a 30-year-old losing a bunch of weight, it's going to be-- they're going to have a better rebound effect than someone that's a little bit older. And just when women have pregnancies and they stretch their abdomens out over a period of 40 weeks, for many people they do get some rebound of that skin and really a lot of it can be genetically mediated. In a very broad context, I think that a lot of it is dependent on what you're doing and what bothers you enough? For some people, they're completely comfortable pulling on some Spanx and going about their day for others that would be problematic, but I would wait till you get closer to your goal weight before examining what options are available. What do you think Melanie?

Melanie Avalon: Yeah, I know Dr. Fung has talked in the past about how one of the things they noticed in their weight loss clinics with fasting patients is that the fasting patients wouldn't experience all or at least the extent of saggy skin effects that people often see with weight loss. And I think he's proposed that it could be something with the autophagy that's going on there helping to mitigate that effect. I do think that losing weight with fasting can potentially have a more beneficial effect on the excess skin and the effects like. I agree completely with everything Cynthia said. This is something where depending on how intense it is, I know Dylan was saying that he was not so much interested in expensive creams or lotions. I do think most creams or lotions are probably not going to do that much. That said I actually do think there is a benefit to some topical treatment especially because you can put these compounds directly on the skin. I would to formulate some sort of cream in the future that might help with skin tightening. That said the most effective thing is probably going to be what Cynthia mentioned with the lasers and the things like that. I actually really, really like-- I've done something called CryoSlim, it's a cold therapy application and a warm therapy that has a really nice skin tightening effect, also building muscle in the area can be great depending on where the area is filling up that area with muscle and having a beneficial effect on the perception of the skin. And especially I've talked about it before, but I've been doing a lot of EmSculpt, which is muscle stimulation-- electrical muscle stimulation and I've actually built a lot of muscle using it. And it has the added benefit if you do the Emsculpt Neo specifically.

It also has a radiofrequency application, I believe it's radiofrequency that also has a skin-tightening and fat-burning effect. And so, people might think that who am I to make a testimony about this? But I think when you do get down to the really intense lingering things, you really can tell what is working and what's not. And I've seen a huge effect on some personal areas doing the Emsculpt Neo in particular. And I really, really like that because you get the muscle-building effects, which is going to have a huge benefit for metabolic health. And then on top of that it seems to have a really nice effect on the skin surrounding the area as well. But then there are also lots of other skin tightening options and I do think there're a lot there. So, you can just like cut those different options out, again that is going to be a more expensive and committed route to go. Shall we go on to our next question?

Cynthia Thurlow: This is from Marilee and the subject is "Hair dyes." "Hello, do you dye your hair? What do you use? Hair dyes have all the nasty ingredients, so I'm wondering what are your thoughts on that. I am bleaching my hair monthly and I'm wondering where all the nasty stuff I'm ingesting through my skin. Also, I'm from Estonia and was shocked in a positive way that Melanie has two podcasts with my fellow Estonian, Siim Land. Best wishes," Marilee. Melanie, what are your thoughts on this?

Melanie Avalon: Also, I did not plan this last week. I know we were talking a lot about Siim Land. I am all about the nontoxic environment, cleaning up our exposure to toxins in our environment. I don't know how much I can talk about it. I feel I talk about it all the time. I'm going to be completely honest and transparent. I haven't done this with my hair dye. I'm actually blonde, I'm dirty blonde, I lighten it, I probably should look more into this, but I've just personally decided that I've cleaned up everything else so much, all of my skincare, all of my makeup, my food, my environment, the hair is the one thing where I'm just going to just do it and I'm not going to stress about it. That said, I know it is probably something in the future that hopefully I will look into more. And I did look into it little bit and interestingly I have a Facebook group you can join called Clean Beauty And Safe Skincare With Melanie Avalon. And people have asked this before, somebody actually asked about this last week, which was perfect timing. And there were about 30 comments of people having suggestions. Some of the things that came up and I would recommend that you do some further research on these because again I don't have experience with them. And I didn't hardcore vet them. Well, a lot of people in the group-- I actually think that the nature of the question was somebody was saying she wanted to use henna and again this would not be for lightening. This wouldn't be for Marilee's issue. But for people who are going dark, she was saying that she was thinking of using henna and her hair girl was saying that it could have heavy metals in it and be an issue. Comments, people were saying they did not have that experience and we're not aware of that and I haven't seen that anywhere else. So, I don't know if that's an issue, but henna is often used to go darker.

There's a brand I found called Light Mountain and again, it's really hard to know if this is greenwashing or not. And by greenwashing, I mean are they just using a lot of words to make it seem really great when it's not, but I think erring on the side of at least companies that are purporting to be more nontoxic is probably a safe choice. On Light Mountain's website they say that the premier natural hair color and conditioner product line, they say they use no chemicals, no synthetic ingredients, only pure premium henna and other botanicals that they've been blending since the 1980s and are leading totally natural line in the natural products industry. So, you could look into them. Another person recommended Tints of Nature, which they actually sell on Thrive Market and according to them they say we use the lowest possible levels of PPD pigments and leave out harsh ingredients like ammonia. They say they ensure that all of the ingredients are high quality and sourced from responsible suppliers who do their bit to protect the planet. They believe that natural ingredients are better and they prefer to use kind and gentle natural and organic ingredients that give love back to your hair. They leave out synthetic nasties like ammonia parabens, resorcinol, I don't know what that is, and sulfates and they say the only time they use synthetic ingredients are when they cannot find a suitable natural alternative. That might be an option to look into. A lot of people have recommended Madison Reed, it was hard for me to evaluate if they are great or if it was greenwashing. But in any case, it's probably better than what most people are normally getting, so that might be something to look into. So those are the options that I am recommending. Cynthia, do you dye or color your hair?

Right now, I'm doing a lot of Lowlights because we're heading out of summer and I actually like a really ashy blonde. With each kiddo, my hair got darker and so I do partial highlights throughout the year. I don't use bleach because I have that ashy look and so there's a constant battle to keep that ashy look and not be gold and so bleach for me doesn't really work well. Admittedly my hair is definitely an area where I struggle a bit to find cleaner products. I use things like argon oil to help with frizz and that's obviously clean that's made in Morocco and you can find organic derivatives. But I would say the two that I'm most familiar with the clean hair dye options or cleaner, Madison Reed as Melanie also just identified and also there's a company called Arctic Fox. I have a couple of girlfriends who use that, it's vegan. According to them it works really well on lighter-colored hair, but can work well on dark hair as well. Beyond that, my hair colorist, we try to find the cleanest options that are available but this is definitely an area where I'm constantly a work in progress because I have very coarse hair and so for me using the super clean shampoos generally don't-- They don't clean my hair all that well and they don't moisturize it sufficiently so we're constantly trying different things to find cleaner options, but Arctic Fox and Madison Reed are two options and I think those are available to people that they can purchase on their own. You don't have to purchase it through your hairstylist, but yeah there's not 100% consensus on finding things that are easier on our hair and nontoxic. I know a lot of people, you're starting to see emerging trends. I'm starting to see a lot of women that are middle-aged that aren't dyeing their hair anymore. For me, I don't have a lot of gray so that wouldn't per se necessarily help me out, but I think for each one of us we have to pick our poisons if you will, and for me right now I just haven't been able to go 100% clean on shampoo or hair dye, but I definitely endeavor to keep looking for cleaner, safer options.

Melanie Avalon: So, on the shampoo, conditioner front. I do love, love, love, Beautycounter's shampoo and conditioner. It doesn't weigh my hair down. I just really love how it makes my hair feel. They used to be called Free & Clear. I think they're now called Vanicream, but they make a completely unscented allergen-friendly shampoo and conditioner. I like their shampoo. I like to pair actually their shampoo with the Beautycounter conditioner. Because I find if I do the Beautycounter conditioner and shampoo sometimes, it's too moisturizing for me. I also love their hairspray. I wish Beautycounter would make a hairspray, but I really, really like, like I said I think it's called Vanicream now. I really liked their Free & Clear hairspray, it has no perfumes and works really well. So, I'll put a link to that in the show notes as well. I can't believe I used to spray my whole face with all this hairspray that had all those perfumes and compounds in them. I shudder thinking about it. Now whenever I go get my hair done, she always wants to bring out the hairspray at the end. I'm like no, don't. Don't spray that on me.

Cynthia Thurlow: I think it's challenging and I don't pass judgment on people that are navigating how to make better options. It's interesting we're doing a webinar on Sunday night talking about cleaner options for your home and for your makeup. And I'm very transparent and just share with people that there are some things that are easy for me and some things are harder, and you just do the best that you can. And if you're avoiding 80% of what's out there, you're doing pretty darn good. So, don't beat yourself up.

Melanie Avalon: Yeah, I have that experience recently because I really wanted to try eyelash extensions. I was going on a trip to Austin and so I wanted to just try them and not have to deal with mascara. And I was researching it I was okay, well, this is going to require chemicals. But you just got to choose what you-- the cost benefit of everything. I did them, they were super fun, I will say that I took them out and I freaked out by how much my eyelashes seemed shorter. And it's hard to know if they actually were gone or if they just seemed so different compared to the extensions. But then that's the situation where-- so the way I start with eyelash extensions, putting them on the application process seemed more a one-off compared to a chronic administration. When I took them off, I was I've got to find a growth serum. I really wanted to find a clean one. And oh, my goodness, I am obsessed, friends, get this now or if you need gifts for anybody. I tried DIME Eyelash Growth Serum, it's amazing and that's something if you're going to be using it, you're probably using it every single day. So, it was important for me to find a clean version of it. The growth, I'm so excited because now I honestly think I'm going to have fuller more lush lashes than I did even before the extensions because I'm using this every single day, I'm just going to use this every day for the rest of my life. So, if you go to melanieavalon.com/dime the coupon code MELANIEAVALON will actually get you a discount sitewide but definitely try that lash growth serum. But yes, I definitely agree with you Cynthia about-- do the best you can, do a cost-benefit analysis, and just do what works best in your life.

Cynthia Thurlow: Absolutely, and I've had good luck with castor oil, that can be helpful for people that feel their eyelashes aren't as vibrant as they once were. I know for my eyes are super sensitive, so I could never be one of those people that could do eyelash extensions. But when I do special events, I'll do the individual eyelashes that are just temporary and I'll do those, and I can always feel like by day two my eyes are, "Please get this stuff off." I think a lot of it has to do with the glue. I certainly have had some friends who've done really well with eyelash extensions and others that have struggled a bit, so lots of options there for sure.

Melanie Avalon: Well, I'm really glad I did them, they were super fun. If I hadn't done them, I wouldn't have looked into this growth serum. And now I'm just really excited, it's like I'm going to have the most luscious eyelashes ever naturally. I had one more comment "Oh, castor oil," castor oil just makes me want to cry. When I was in my really-- my face when I was really struggling with constipation, people will recommend castor oil to fix that. Have you ever taken castor oil? Have you ever--

Cynthia Thurlow: I never have.

Melanie Avalon: I can't even think about it. It is the worst? It is the most foul thing I have ever put in my body, the taste of it is just mm-hmm. Yes, castor oil makes me shudder. But that's different than you're saying putting it on your eyelashes.

Cynthia Thurlow: Yes.

Melanie Avalon: Very cool.

Cynthia Thurlow: Yeah, I have some friends that have had really good luck with that.

Melanie Avalon: Nice. If it didn't make me want to cry, I would try that.

Cynthia Thurlow: No, we don't want to induce crying, that would be bad.

Melanie Avalon: Listeners, though, can check out the show notes. We'll put links to everything that we talked about. I feel bad for our editor, Brianna for this one because there're so many show notes to create. Okay, shall we go on to our next question?

Cynthia Thurlow: Mm-hmm.

Melanie Avalon: We have a question from Kelly. The subject is "Cortisol." And Kelly says "Hi ladies, thanks for all that you do for the podcast. It has helped me and so many others. I've been listening since episode 3." Wow. "And look forward to the new podcast every week. I've been intermittent fasting for six months now and loving it. One side effect I've noticed is being easily startled in the afternoon before I break my fast. I sometimes have one cup of coffee early in the morning, but notice it on days that I don't have coffee too. Does this have to do with cortisol levels, can you speak to the effect of fasting on cortisol levels as a whole?" Thanks.

Cynthia Thurlow: Well, Kelly, there're many things that could impact how you're feeling and when we talk about coffee, quality is certainly important. Much a lot of crops, coffee is prone to exposure to mycotoxins or mold. When people sometimes feel differently on days that they're consuming coffee or not consuming coffee, I always think about contaminants. But obviously, if your body is dependent on the caffeine that could also explain why you are feeling like you're having a slump in the afternoon and yes, could that be mediated by cortisol, it could also be mediated by what you're breaking your fast with. So, there're many nuances here. Cortisol is definitely influencing many things that go on in the body, cortisol goes up in response to our circadian biology. And when we get up in the morning, that's when cortisol should be highest. it ebbs and flows throughout the day, and is lowest in the evening, except for our unicorn co-host, Melanie Avalon. But certainly, in me that's how you know, my energy is greatest in the morning and early afternoon, and then throughout the rest of the day, it's waxing and waning, but still fairly consistent. But you have to think about fasting as a hormetic stressor. If your body perceives it's too much stress, it can increase your cortisol in a non-beneficial way. And so, I think you really have to take into account many things when considering the net impact on fasting, it can be impacted by the foods you choose to consume, how's your sleep, what's your stress management style like? What kind of exercise are you doing? Where are you in your menstrual cycle? All of which can be impacted negatively or positively by when or how much fasting you are embracing? I think really sitting down and getting nuanced about how caffeine influences how you feel in the afternoon, you mentioned easily startled, yes, caffeine is a stimulant, so some people are slow metabolizers of coffee or caffeine and others are faster metabolizers of caffeine and so that can also play a role as well. But I think looking at it comprehensively getting a little bit nuanced and also understanding, not wanting to overfast because that can impact your cortisol, understanding where you're on your menstrual cycle and how is stress and sleep and nutrition impacting your cortisol as well? What do you think, Melanie?

Melanie Avalon: So, speaking to the fact that she has this startling effect if she has coffee or not. It sounds like she's having this wired feeling regardless of the caffeine. And it probably is related, I would guess, to fasting and being in that sympathetic state. So, the fasted state does upregulate hormones and neurotransmitters that are energetic and make you active, so norepinephrine, epinephrine, cortisol. Yes, that startling feeling, coffee or not that you experience with fasting definitely could be playing a role. As far as the effects of fasting on cortisol levels. We actually talked about this in a lot of detail on an episode where we were discussing a study, I think it's when we were talking about a blog post that Dr. Sarah Ballantyne had done on this, and she referenced a study looking at the effects of fasting on cortisol levels. And, actually, I think it was the effects of later eating--fasting with later eating on cortisol levels. And the fascinating thing about that study is I went and looked at it and it seemed that having a fasting window during the day with eating later, really did create the cortisol pattern that we'd want to see with the caveat of like Cynthia saying over fasting and having too much cortisol, but basically, our natural cortisol rhythm, we should get a bump in the morning with the dawn effect. And the purpose is to prep the body with fuel for the day, release glycogen from the liver, so you can get up and go and as a hunter-gatherer get up and go find your meal. It's normal to see a cortisol bump in the morning and then it should slowly taper throughout the day.

It seems that eating later can further stimulate that pattern where you have higher cortisol in the morning and lower cortisol at night. I think fasting can pair really well with cortisol levels. But again, you do want to be careful, Cynthia was saying that you're not going too much with it and releasing too much cortisol not being able to have a beneficial cortisol pattern. It's also interesting. I've interviewed Dr. Michael Breus on my show multiple times. He points out that most people should have these normal cortisol levels, but there's one chronotype-- one sleep chronotype that he calls the dolphin which I am and we're unique in that we naturally get a cortisol bump at night, regardless. I think that's actually a reason that I do so well with eating at night is because I can counter that cortisol bump and because when I eat my main, my big meal, I find that it really reduces my cortisol levels. Well, I don't measure them, but I'm assuming it does. That's the experience that I personally experience. And so that's one reason that I really like my fasting pattern for me personally with my cortisol levels. But yes, the startling it is, I can definitely see how fasting would be encouraging that response.

Cynthia Thurlow: Yeah, absolutely. And I think this is where that piece and bio-individuality really plays in. As an example, Melanie and I are recording this podcast at 5:45 PM, which means she's just getting revved up and my body is okay, we're going to be in bed in a couple of hours. And I think, really leaning into our physiology and doing a degree of experimentation to find out what supports your body. I know I have plenty of patients and clients that do better with tea as opposed to coffee in many ways, there can sometimes be less caffeine in some of the bitter teas. I would experiment to see how you respond to that. You can certainly, depending on where you are in your menstrual cycle, you may respond more readily and more easily to longer fast, shorter fast, etc.

Melanie Avalon: Yeah, that's a great suggestion. Yeah, a lot of people do well with the green tea and also a lot of people, I've seen people pair theanine with caffeine and find that it can mitigate some of that so that people can have a less stressful response to the caffeine. So that might be something to try.

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With Green Chef you're actually reducing your food waste by at least 23% versus grocery shopping, plus the recipes are delicious and perfect for the holiday season. They have their festive fair, which is a curated collection of premium dinners to help make your holidays feel extra special. You have the option of USDA-certified organic ground beef, certified organic chicken, and wild-caught sockeye salmon in any meal and you can also add chicken or fish, to select vegan and veggie recipes if you want to add a protein boost, their keto meals are delicious. I know Cynthia loves those, they make sticking to a carb-conscious lifestyle easy. The meals come with pre-made and pre-measured sauces, dressings, and spices to make holiday hosting easy peasy leaving you more time to celebrate. And I love that I can use high-quality ingredients and really make them my own. I can choose if I want to leave out some things or what I do want to include to make it really what I want to eat. But of course, most people will probably just eat it the way it's recommended, which is delicious. I got a salmon with creamy chimichurri.

I left out the sweet potatoes and instead kept the salmon, the shallot, the cilantro, the pumpkin seeds, it was so delicious. They also have quite a few barramundi meals which is so exciting to me because barramundi is one of my favorite fish of all time. And Green Chef has an incredible offer for our audience, do not miss this. You can go to greenchef.com/ifpodcast and use the coupon code IFPODCAST to get $5.99 per meal on your first box and your first box ships free. Go to greenchef.com/ifpodcast and use code IFPODCAST to get $5.99 per meal on your first box and your first box ships free. Green Chef is the meal delivery service that you need and that I endorse. Do not miss this offer, Green Chef, the number one meal kit for eating well. And we'll put all this information in the show notes. All right, so we go on to our next question.

Cynthia Thurlow: Sure. This is from Lynn, subject is "Jetlag." "I love love, love your show. I'm working my way through your previous episodes. It really helped me the first couple of weeks of intermittent fasting to listen to your shows daily. I started on January 1, 2018 and I'm down 19 pounds and counting. I'm currently doing one meal a day. My question is regarding travel and eating to prevent jetlag. I heard about a study from some, can't remember which one, a university that to start eating a day before on the time of the place you're going to prevent jetlag. Have you ladies traveled far? And how do you do with jetlag? I'm in Hawaii to meet up with my husband who is stationed in Japan for two years. It's a quick trip. Intermittent fasting makes it easy when you're traveling for sure. I really struggled with jetlag yesterday, I also use melatonin and a homeopathic med to help. I still struggle with it. Even in Hawaii, I still want to eat at my scheduled time in Virginia. I am going to Japan this summer, who knows what or how I'll feel in Japan? Any thoughts on food, intermittent fasting, and jetlag? Thank you for all you do. You are an inspiration for all of us out there trying to make this work."

Melanie Avalon: Awesome, thank you, Lynn for your question. I used to travel internationally, I mean, relatively a lot, every year mostly. I haven't done that since I've started fasting. I've just traveled domestically, but I can still speak to it. And I'll be super curious to hear Cynthia's thoughts because she's traveling all the time, I feel internationally. There's been a really interesting study on jetlag and fasting specifically and how fasting can help basically mitigate the effects of jetlag. And the way the setup is, is rather than eating before, she's talking about starting with the way she's eating before traveling, they advocate just once you get to the new place it's fasting and then eating on the time zone of the new place once you get there. So, personally just traveling domestically, so obviously, the biggest difference would only be a three-hour difference. I found that I have zero issues. Whenever I travel between LA and East Coast regardless of which way I'm going, I just fast as I normally do, and then I eat my dinner in my new location. And it immediately sets me back to that wherever I am, I have zero issues, zero.

Our food and our circadian rhythm regarding our food intake can heavily influence our sleep circadian rhythm. Because if you think about it, you could be completely awake and then you could eat a massive meal and get really tired or you could be exhausted and fasted and hungry and not be able to fall asleep. There's a big effect on our food intake and our sleep. It could be a really nice hack to use fasting and then just eat on the time zone of we're going. But again, I haven't done this internationally. Cynthia, what are your thoughts?

Cynthia Thurlow: This is such a great question. Because I am a world traveler. This is one of my great joys in life is traveling. So gosh, in the past 18 months, we've been to Africa, we've been to Europe, I do a lot of West Coast travel. I do find for me I just get on the plane and I generally just fast and I stay hydrated. And then as soon as I arrived, so I try to get on the schedule of wherever I'm going. So, if I arrive in the morning, what typically happens when you arrive in Europe, you're arriving in there morning, I will try to stay fasted until lunchtime, which is generally when I break my fast. Obviously, when I've traveled to Africa, most recently, you arrive in the evening. And I typically-- if I'm hungry, I'll eat but if I'm not hungry, I'll just go to bed and then the next morning, I'll get up and I'll eat around the time I would at home, even though it's the middle of the night at home. But I think when you really look at the research, it takes about one day per hour of time difference. So usually, a solid week in Europe when it's six plus hours ahead and in Africa, I would imagine Japan is going to take a bit longer because that's more than 12 hours I believe ahead of the East Coast. But obviously, it depends on where your husband is stationed. I think that you can absolutely integrate fasting into helping support jetlag, I think staying really well hydrated and trying to get light exposure on your retinas is going to be important. The other thing I've learned is that I travel really well when I go East and I always struggle a bit more when I go West, I can actually travel more easily to Europe or Africa. And I struggle more when I go to California and I suspect it's because being ahead is easier than being behind.

So, my body at 8 o'clock at night is saying it's really late for me, "Don't laugh Melanie." 11 o'clock at night is late for me, but in my mind even though it's 8:00 PM pacific standard time my body is really struggling to stay awake. I think just understanding it's going to take a period of time, it could take up to two weeks, you may be actually in Japan for that amount of time, so it may take a bit of time to acclimate. And really just being open to the fact that you're going to have a couple of days where you're probably going to drag. But the one thing that I've learned that's been really helpful is staying hydrated, resting when I need to, and then making sure I'm eating the proper macros. Again, protein, vegetables work really well for me regardless of where I am, if I start eating a bunch of junk and I start drinking a lot of alcohol, which I don't do, that would definitely worsen the jetlag for me, so hopefully, that's helpful. And enjoy your time in Japan.

Melanie Avalon: It's so funny, that really speaks to the bio-individuality aspect because for me traveling from Atlanta to LA, I love it because it just gives me a longer fast, it basically adds on, I guess, three additional hours of fasting and I often think every night anyways, "Oh, I could fast for another three hours." So, it's my dream situation. I'm curious, did you have a different experience of jetlag and all of that before you were fasting?

Cynthia Thurlow: I have been, so this is our-- I say everyone has priorities and travel has always been hours. I struggled more with jetlag when I was in my 20s. By the time I got to my 30s, so obviously my 20s and 30s. I wasn't fasting. When I got into my 30s, I remember when we went to Greece for our honeymoon, I was miserable trying to stay awake. So, do I think that fasting probably has helped, potentially, I think I'm also much more aware of the net impact of lifestyle and how that plays in with jetlag. And, I probably walked around chronically dehydrated for years, which probably exacerbated my jetlag. So yeah, I can honestly tell you that I was that person who walked around feeling I was drunk for days. And it was because I just couldn't get over that sleep pump. And, obviously, I would say I've traveled pretty effortlessly since fasting, largely because I understand how to fuel my body. And I think that makes a big difference. And honestly, more often than not, when I'm in an airport or when I'm traveling even domestically, I generally will stay hydrated. I'll drink a lot of electrolytes, but I'll just fast in anticipation of wherever I'm going to. That's a good question.

Melanie Avalon: Fasting is such a wonderful hack and tool for travel I think and not having to deal with airplane food and not feeling chained to having to deal with the meal aspect of it. And yeah, I just find it so, so helpful.

Cynthia Thurlow: Absolutely, and I think it's interesting that one of the standard questions that I think we both get on social media is what do you do when you travel? So, I always travel with the if in need these are the things I'll eat, but I always travel with, Paleovalley beef jerky. I always travel with salted Macadamia nuts, because if I get in a position where I'm really hungry, I don't want to eat crap and most airports here in the US there's a lot of junk, I mean, occasionally you get unicorn airports but generally, there's just a lot of processed junk so, I always have that available if I need it. But it's easy just to stay hydrated. I mean I used to carry glass water bottles and depends on how much traveling I'm doing but now sometimes I'll just go in and buy, I know it's trying to find the happy medium of do I want to carry around a glass water bottle for four or five days or do I want to just buy a bottle of FIJI water and use some electrolytes in it and just forgive myself for the exposure to plastics and just be done with it.

Melanie Avalon: Yeah, goes back to deciding what's worth it and what's the cost-benefit and I will comment on the melatonin piece. I'm a huge fan of melatonin, I had concerns about it down-regulating melatonin production and whether or not I should take it nightly, but learning more about it, especially reading Dr. John Lieurance's book, I think he calls it Melatonin Miracle. I learned a lot about melatonin and realized it has a lot of antioxidant effects and people do high-dose melatonin supplementation and I've interviewed Dr. Kirk Parsley about this and he has a little bit of melatonin in his sleep remedy supplement which can be really, really amazing. Oh, by the way, I definitely recommend that supplement if you are looking for something to help you naturally fall asleep without pharmaceutical aids. We can get it at melanieavalon.com/sleepremedy and the coupon code MELANIEAVALON will get you 10% off. I think if I were to travel something where I had to just make myself fall asleep because of the timing issue, I would definitely probably do some high dosing of melatonin. I think Peter Attia has talked about this and I think he's more hesitant about melatonin, but he did say on a podcast I listened to recently that he will do the high-dose melatonin route to adjust to time zones.

Cynthia Thurlow: It's interesting, I interviewed Dr. Kyle Gillett, he is a functional medicine provider and we talked about melatonin because to me I use melatonin and it is a master antioxidant. Yes, it can help with sleep, but there are so many benefits and for people North of 40 in particular, many of them have very depleted amounts of melatonin in their bodies. And so, thinking of it from that perspective is very different. But he actually said in all of his patients North of 40 that he has not opposed to them utilizing supplemental melatonin. I think it can be helpful for those that are traveling. But I also think from the perspective of just aging in general. I do find for a lot of my patients and clients, they do very nicely if we do testing, and we confirm that their melatonin levels are pretty low, their urinary metabolites on the Dutch that using a titrated, meaning we go up and we come back down, we'll use a titrated approach to melatonin. I've had some pretty incredible results with utilizing that and I do have a very-- and maybe Melanie, I can talk about this on another podcast, I have a very stepwise approach to sleep support. And I'm very serious about my sleep, very serious about my sleep. So, there are definite products that I think can be very beneficial, melatonin can be one of them. I really personally like MD Logic's product. They're actually reformulating their melatonin, so it's going to be 100% clean, no rice flour or anything that. But that is probably my favorite melatonin to utilize and it's very potent. I can give the example that Designs for Health has a product called Melatonin SRT, sustained release. When I first tried the MD Logic product, I took the same amount except it was so much more potent the next morning when I woke up, I could barely open up my eyes. I remind people to go low and slow and the MD Logic product, which I know, both Melanie and I, both have codes, mine is CYNTHIA to give you 10% off, but melatonin is definitely a supplement that I think is really invaluable to use. And for those of us that are perimenopause or menopausal, it can be really very helpful for sleep support.

Melanie Avalon: Yeah, I'm so glad you brought that up. And especially with melatonin, that's one of the studies where they've done studies reviewing, I found one where they I think looked at 30. They looked at, I think 30 bottles of melatonin and it was around a dozen or 15 or so brands. And they tested for the actual amount of melatonin compared to what the bottle said and it was shocking. Shocking how far off they were. And this was mainstream brands. So, definitely finding a product that you really, so that MD Logic Melatonin definitely would be one to try. I think I shared this before but I think the thing that sold the deal for me-- I know I've shared this before. The thing that sold the deal for me about "Okay, it's okay I can be taking melatonin," is that night that I accidentally thought I was taking digestive enzymes and I was actually taking melatonin. They were in the same bottle and they look the exact same and I took, I don't even know how many milligrams I took. And I slept so well and because I didn't know I've had high dosed melatonin. I wonder if I would have felt groggy. How much of the placebo effect might have happened? I wonder if I would have felt it more if I realized, but I didn't realize until the next night that I had taken so much. And so, after that I was okay, it's fine, but melatonin.

Cynthia Thurlow: It's good stuff.

Melanie Avalon: All right, well, we'll put links to all of that in the show notes, which will be at ifpodcast.com/episode294. If you would to submit your own questions for the show you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can get all the stuff that we at ifpodcast.com/stuffwelike. And you can follow us on Instagram, we are @ifpodcast, I am @melanieavalon, Cynthia is @cynthia_thurlow_ and I think that is all the things. Anything from you Cynthia before we go?

Cynthia Thurlow: No, I think this has been a particularly enjoyable episode. Lots of good topics.

Melanie Avalon: I agree. So incredible and I'll let you go and wind down your day and I will talk to you next week.

Cynthia Thurlow: Sounds good.

Melanie Avalon: Bye.

Thank you so much for listening to The Intermittent Fasting Podcast. Please remember everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

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Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

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Nov 20

Episode 292: Creatine, Brain Health, Sex Hormones, Muscle Building, Insulin Sensitivity, Sarcopenia, Andropause, Mood, Motivation, BDNF, And More!

Intermittent Fasting

Welcome to Episode 292 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

JOOVV: For A Limited Time Go To joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount! black friday thru cyber monday only get $50 off Joovv Go, $150 off Mini, $200 off Solo, $300 off Half-Max, $400 off Duo, $500 off Max, $600 off Quad, $800 off Elite plus Special Financing Offers! after that Use The Code IFPODCAST For An Exclusive Discount!

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Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

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what creatine does

Creatine Supplementation in Women’s Health: A Lifespan Perspective

GABA Research

creatine and brain health

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gender differences in creatine needs

creatine and sex hormones

sarcopenia

muscle memory

andropause

low testosterone, mood and motivation

BDNF

learning new things

age related changes in the body; Bone health

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hormone replacement therapy

sleep

creatine sources and supplemental dosage

vegans and Vegetarians

Introducing... Creatine by Cynthia Thurlow

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 292 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time and get ready for The Intermittent Fasting Podcast.

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And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream.

And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies when we have babies, a huge percentage of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years.

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life and their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. 

They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list, so definitely check it out. You can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well. 

And lastly, if you're thinking of making clean beauty and safe skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally completely worth it. So, again to shop with us go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now, back to the show.

Cynthia Thurlow: Hi, everyone, and welcome. This is Episode number 292 of The Intermittent Fasting Podcast. I'm Cynthia Thurlow and I'm here with Scott Emmens, cofounder and COO of MD Logic Health.

Scott Emmens: Cynthia, thank you for having me on the IF Podcast. It's a pleasure to be here with you today.

Cynthia Thurlow: Absolutely. Today, we're going to unpack creatine. I think this is certainly a supplement that I used to have probably prejudicial thought processes on, but the more I've understood the science and the more that I've understood about the benefits of creatine, both for men and women, the more I was interested in sharing the research and connecting with you. I'd really love to start the conversation there. What exactly is creatine? 

Scott Emmens: Creatine is organic acid that is endogenously produced in the body. You can also take it as a supplement. It's a combination of three amino acids, which are arginine, glycine, and methionine. It's produced in the kidneys and in the liver.

Cynthia Thurlow: Yeah, it's interesting. When I was doing my research before we even talked about bringing creatine to market, was it the liver and the kidneys produce 2 grams a day on their own and it's all stored in our skeletal muscle. And so, I think from my perspective as a clinician what I understood about creatine was that it was something just utilized by bodybuilders and what I've come to find out is there're so many variations of creatine, there're so many options available. The two consistent things that I saw in the literature that really stood out for me was the improvement on muscle health and muscle strength and then also the cognitive benefits. And so from my perspective, this is something that's applicable to everyone. It's not just gender specific, it really is applicable to everyone.

Scott Emmens: Well, it's been like a second coming from me, Cynthia, because I started out as a biology major and a bodybuilder in college. So, I'm very familiar with creatine. I'd used it back in the days when you took 20 grams and that was it. It was a bodybuilding supplement, 20 grams, by the way, is a lot, way too much, that can really cause some GI upset, kidney damage, and so forth over the long term. But at lower doses, it's really an effective product. What I was so blown away by was after 30 years out of the bodybuilding scene, gauged myself a little, I could not believe how many studies are continuing to go on with this product and how much more benefits that we're seeing across a wide array of issues including brain health. That was one thing that shocked me the most was the number of different studies that are ongoing, or that are in early trials for various different brain health issues.

Cynthia Thurlow: Yeah, and so because you started your experiences with creatine at a different stage of life, what have been some of the common misconceptions that you have seen or heard over the last 30 years particular to creatine use?

Scott Emmens: First of all, that it causes weight gain or weight gain in women, which is highly unlikely, it's not zero probability, that it can be very dangerous with a lot of controversy about the danger of creatine. It's in fact one of the most studied supplements that I've ever seen, it's been studied and researched well over 30 years at this point. So, its safety is pretty much unparalleled. And then the other misconception because, A, it's only for bodybuilders or for only for men, or that it's only for athletes. When in fact the research shows that there are many people that can benefit particularly by vegans and women that benefit from making sure to maintain muscle mass, especially postmenopausal. So, there's just a tremendous amount of research coming up. This is an [unintelligible [00:12:12] nutrient that your body requires creatine. In fact, if you have creatine, it can cause some pretty significant problems.

Cynthia Thurlow: Absolutely. It's interesting because I admittedly was a little prejudicial in my thought process, and I think it was because my knowledge of creatine was really related to the bodybuilding set. At one time, I was an ER nurse in inner city, Baltimore, and I saw quite a bit of people that are using anabolic steroids and they were using other types of supplementation. I'm sure that creatine probably got lumped in with some of the other side effects that were completely unrelated to the creatine utilization and more a byproduct of illegal exogenous use of anabolic steroids.

Scott Emmens: I can attest to that having been in that world, you would get approached with someone trying to sell you something that was illegal on a regular basis. And as a person of health, it just wasn't in my wheelhouse. So, I had to understand how these products worked. And I was a big supplement user in my early age because in order to compete with people that were using anabolic steroids, they can go eat a pizza and still look ripped. Whereas for me I was doing things like creatine and using things like boron and zinc combinations and other minerals, amino acids and branched chain amino acids and the essential amino acids way before they became popular or in vogue. There was definitely a large combination of people in joining creatine and other including diuretic cause other serious problem.

Cynthia Thurlow: Yeah, absolutely. For full disclosure, I had been skeptical about creatine until my very well researched trainer, who's also an attorney, she's got a really interesting background, she was actually sharing the research last fall and kept saying, "I really think you should consider supplementation with creatine." The one thing that I have found personally and we'll talk about this today, the benefits of creatine, how it works in the body was that I went from as a menopausal female, when women really do struggle with not only building but maintaining muscle mass unless they're taking exogenous testosterone. I was able to consistently lift heavier weight week to week and I was able to see more of those gains, and we track all of our metrics because she and I are a little bit OCD about this. For me, I kept saying, "If I am capable of achieving and maintaining muscle mass at this stage of life I am in, then this is something that can be really beneficial for other women and certainly other men that are considering wanting to build maintain muscle mass because we think of muscle as an organ of longevity." Certainly, I follow really closely with Dr. Gabrielle Lyon's work and she was very excited when I told her that I was seriously considering bringing creatine on as my first product in conjunction with MD Logic. 

Let's talk a little bit about what creatine does. From a technical perspective, creatine re-phosphorylates utilized ATP. So, ATP is this energy molecule in the body. Adenosine triphosphate becomes adenosine diphosphate when you move muscles, so your body's using this energy when you're moving your muscles and creatine actually attaches another phosphorus group to ADP. So, it's a way to keep recycling creating the stored energy. And for anyone that's listening that saying, "I don't even know what you're talking about." We're talking about what goes on inside the mitochondria. This is a very savvy science-oriented listener base. And so really think about this is going on in the mitochondria. So, the powerhouses of our cells.

Scott Emmens: I think what's important for people to understand too, is that sometimes we associate ATP with just our muscle cell. But in fact, it's all of our cells. It's your brain cells, your heart cells, all of the cells in your body, your immune cells, every cell in your body requires ATP for energy. If you run out of energy, then you're going to run out of life. What creatine is able to do is to your point, make that ADP back into ATP, which is the foundational molecule for energy, much faster, you got creatine stored in your body and creatine serum in your blood going to replace that quicker, and your brain and your heart probably use up more ATP and more energy that get into organs in your body. So, it makes sense when you think about how it could work for your brain because of the way that works on ATP.

Cynthia Thurlow: Absolutely. It's involved in energy mobilization and metabolism in the brain. I also think about the net impact on things like glycine and GABA, which impacts sleep. As women, especially in their perimenopausal years, 10 to 15 years preceding menopause and their ovaries are producing less progesterone, this is a time when upregulation of GABA is really important for high quality sleep. When you really dive into the research, one of the things I found interesting and there's a great article that we'll link up, it's called Creatine Supplementation in Women's Health: A Lifespan Perspective. Researchers here really talk about how creatine has a place throughout a woman's lifetime, not just perimenopause and menopause, but your menstrual cycle. We're not going to touch on pregnancy or lactation because I don't want to touch that with a 10-foot pole, but there is research that kind of touches on how this can be beneficial. 

It's not just as you said, it's not just the muscles, but it's really a systemic supplement that has a lot of benefits. The one thing that I really like about this article in particular is that it admits despite extensive research on creatine evidence for use among females is understudied, so they acknowledge like many things, there's not enough research being done on women in peak fertile years, in perimenopause and menopause. But they do see the importance, it actually says supplementation during menses, pregnancy, postpartum, during and post menopause. Again, we're not talking about pregnant or lactating women, but we'll talk about women that are still in their peak fertile years, perimenopause, and menopause, that there really are quite a bit of benefits from supplementation.

Scott Emmens: Yeah, absolutely. It's not surprising that it wasn't studied and even that happens, they're quite often. I did find it interesting that there are some variations in women that have or store creatine. So, I'd like to talk about that when we get a chance. But I didn't read this research that you read on sleep and GABA upregulation. Tell me a little bit more about that.

Cynthia Thurlow: It's interesting that it can have a positive net impact. There's an excitatory neurotransmitter and that's glutamic acid and then there's inhibitory neurotransmitter and that's GABA. The thought processes is that the creatine absorption will upregulate the inhibitory neurotransmitters, it also has some impact on neuronal ATP resynthesis, which impacts areas in the brain that will impact memory, cognition, and attention. Again, it's downregulating excitatory areas of the brain and helping to facilitate concentration as well as relaxation. There was research and in one of the articles that I had shared with you talking a little bit about the sleep piece, it wasn't a huge area of focus but I think in particular, for individuals that are north of 35 or 40, where sleep becomes much more of a-- I always say jokingly, it becomes an art form, all of a sudden you have to think a whole lot more about it. You have to think about what you're doing preceding bed, what you eat, what you drink, whether that's alcoholic or not, and all the things you need to do in order to help facilitate sleep.

One of the things that it talks about in particular was this brain metabolism and then also secondarily to that it's involved in the synthesis of key neurotransmitter, so it's actually found in the cerebral spinal fluid, which is important. There are actual dopamine and serotonin and creatine metabolites that they're finding in the cerebral spinal fluid, which means that it must have some good absorption. When we talk about the blood-brain barrier, there are some things that are able to cross the blood-brain barrier and there're some things that are not able to cross the blood-brain barrier and so that's pretty significant. If we're getting cerebral spinal fluid levels, then you've got some good absorption in the brain, which a lot of supplements and drugs do not have good absorption in the brain, and that can complicate how well or how effective they can be.

Scott Emmens: I saw another article on just specifically creatine and brain health and talk about being able to cross the blood-brain barrier. The fact that it was able to do that really gave the brain some neuroprotective properties as well. And they think that that also could be because the brain has more energy. That was interesting. I think this goes back to the ability to focus and concentrate, not get excited. It's usually if you have a stimulant or something that gives you energy going to make you jittery, but this has the opposite effect where it calms you, but also gives your brain the ATP that it needs to perform. And so, the hypothesis is that your brain fatigue comes from the fact that it's eating up the ATP faster than it can create it, so that that creatine crossing the blood-brain barrier really allows your cognition to be at a constant steady level, because, I think, where the real benefit for so many of us come from, if you're getting good sleep on top of that, well, then your cognition is going to just continue to enhance.

One thing I just want to go back to, Cynthia, you said when you first started taking it, you felt yourself getting stronger. I wanted to point that out because as a former bodybuilder and a trainer, one of the things that happens, you can start to lift heavier weight, it then becomes a positive cycle upward. Because as you lift heavier weight, you get stronger, as you get stronger, you get bigger and stronger muscles. Of course, you hit a point where you've hit a plateau, but the fact that that gives you that jumpstart to be able to lift heavier weights allows for both your skeletal system to get stronger, your joints to get stronger, as well as your muscles to get stronger and protect yourself from sarcopenia, and we're going to talk about later, which really is serious at the end of the day. I mean, it's sort of the beginning of the end stage of life and certainly a predictor for longevity.

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Cynthia Thurlow: I think that a good place to start is perhaps talking a little bit about gender differences. There's no question that men and women can both benefit. But it's interesting, from a perspective that women actually make less creatine than men as a standard. That could be related to so many different factors but understanding that just at a cellular level, our bodies make less of this substance. I would argue that it makes it even more important to consider supplementation to help maintain muscle mass, brain cognition. When we're really looking at such a small percentage of the population, back to brain health, only 7% to 8% of Americans right now are metabolically flexible. This is research looking post pandemic, pre-pandemic it was 12%. Now even less people. And so really thinking about ways to augment metabolic flexibility. One of those is really leaning into lifting weights, intermittent fasting or eating less often. It could be 12-hour feeding window, just really understand there are a lot of things within our control that we can do to utilize supporting health and wellness. 

I always say, "My greatest hope is that people look at-- They don't fear aging, but they understand that you don't want to just survive, you want to thrive at each stage of life." If you're peak fertile years, perimenopause, menopause, really important to understand you want to have a high quality of life.

Scott Emmens: Absolutely. There's definitely differences between men and women. Women do make significantly less creatine. From the research I could see, estrogen did play a role in that and it did go along with the cycle. There definitely seems to be something there, which to your point makes it all the more important for certain populations, I think women being one of them, which is ironic because it's been utilized in male bodybuilding role for so long. But in reality, women will benefit tremendously from creatine.

Cynthia Thurlow: Yeah. There's a really good graphic that's in this one study that I'm looking at. It's talking about the menstrual cycle may influence creatine homeostasis due to the cyclical nature of sex hormone regulation. You mentioned in particular that it's sensitive to estrogen, which also explains why women and perimenopause and menopause that are having these faltering amounts of estrogen may have even greater needs. But you can actually plot on this graph they have on the X-axis is creatine kinase activity and estrogen and progesterone concentrations and then on the Y-axis, they're looking at different phases. The follicular ovulation, luteal phases, which everyone in this podcast is very familiarized with. You can literally look at how they plot out. Glycogen storage, carbohydrate oxidation dependent on how much sex hormones are and where they are peaking and where they're ebbing and flowing throughout the menstrual cycle. 

It's interesting that we know that estrogen influences creatine and also creatine kinase, and that estrogen in and of itself is a master regulator of bioenergetics. What does that mean? As we are losing estrogen either in our menstrual cycle, or in perimenopause or menopause, it is a direct reflection of the loss of insulin sensitivity. So, obviously, in middle age, it's going to eventually be a permanent thing unless you're taking hormone replacement therapy. For menstruating women peak fertile years, they have cyclical alterations in their estrogen month to month and that is the ebbs and flows. They have days where it's higher and lower throughout their menstrual cycle, whereas with middle*aged women, they're on a downward trend. Ultimately, they'll be on a downward trend.

Scott Emmens: Yeah, that's very interesting. When you said that estrogen is the master hormone for-- what was the word that-- [crosstalk] 

Cynthia Thurlow: They use the term bioenergetics. 

Scott Emmens: Bioenergetics.

Cynthia Thurlow: Which makes sense.

Scott Emmens: So, essentially, once you have no estrogen, your bioenergetics is essentially completely downregulated.

Cynthia Thurlow: You're no longer in anabolic growth phase of any kind, you're really in this catabolic phase unless you're actively progressively working against it. From my perspective, is we've touched on sarcopenia, which is this muscle loss with aging. It's not a question of if but when. People if you think you do nothing and I can now recognize middle-aged women or even older women that are just skinny, and it's because they've lost their muscle mass. They really start replacing adipose tissue, which is highly inflammatory with our muscle tissue. I always use the analogy because I'm very visual. When we're looking at nonsarcopenic or healthy muscle tissue, it looks like filet versus a ribeye. People love eating ribeye but we don't want to become a ribeye, and I use that to understand, like the marbling in the meat is what starts happening to your muscle, because you're losing muscle mass. 

In fact, I was at an event this summer, actually, with Gabrielle Lyon and a few other people. There was a special type of scale that you stepped on. And it could tell you pretty accurately how much muscle mass you had on. She and I had a pretty good laugh when we're looking at my results. But the point I'm trying to make to everyone is that you want to maintain muscle mass, like your life depends on it. I don't think I appreciated that enough in my 20s and 30s. Certainly, you start seeing the slippery slopes. Forty is about when we start losing a significant amount of muscle mass, and then it just accelerates. So, you want to be doing all the things you can to maintain as much as possible, so that you're less at risk for metabolic diseases, insulin resistance, etc.

Scott Emmens: Cynthia, I've heard you talk about this on the IF Podcast before and in Everyday Wellness as well, that sarcopenia creeps up on you. But also, when you're in your 20s and 30s, what should you be doing? In my personal opinion and experience, people that have built up their muscle in their 20s and 30s, when they have all those natural anabolic hormones circulating through the blood tend to do much better when they hit their 40s and 50s if they're continuing, even if they're just doing a maintenance work out or just push up and pull ups, the basics. You'll see that the people that kind of had that foundation tend to stay better. It's never too late to start right, but if you're in your 40s, and you haven't been working out, you probably should hit the gym and get a trainer and learn how to work out is the point of no return. And that's the point where you've really got to face the fact that, "Hey, if I don't have muscle in my 60s and 70s, my knees are going to be rough. And that's the way you don't just have longevity, but you have health span. If you want to be healthy in your 80s, you got to be able to get yourself up out of a chair without using your arm, just to be able to stand up. And that sounds easy. But when you're 80, it's not so easy. 

I completely agree that, A, you've got to make sure that you have a foundation if you're 20 or 30 now you're listening to this podcast, start making your muscles strong now. You won't regret it. You will never regret having really strong lower legs and really strong arms and shoulders, and a strong back and a strong core. You've never going to regret that. And creatine is one of those things will help you get to that place in a very natural way. It's a natural substance that you get from meat, but your body is usually excreting more than it's taking in and extra creatine has been demonstrated time and time again to help you get there. 

The other statement which I thought was profound is that you're in a constant state of anabolic state, constant catabolic state after menopause. That basically means you're eating your own muscle tissue. And that is a dangerous place to be. I would really recommend those folks also hit the gym, take both protein whether that's in the form of essential amino acids or whether that's in the form of a protein powder, combined with the creatine, or get the protein from your diet. That’s how you got to be getting about a gram per pound, in my opinion, protein a day. It might be less, women may be 20 grams per pound, you definitely need to have that protein. And creatine is one of those things that'll make that proteins better for you. All that said, it's all going to work much better for you if you're working out with weight.

Cynthia Thurlow: No, I agree with you and you really bring up some excellent points. I always use myself as an example because it makes it relatable. We have muscle memory, so if we've been working our muscles for years, or even if we go through a period of time where we take a break, when we go back to training, we'll be able to get back to where we were a little bit faster than someone that's new. But in 2019, I spent 13 days in the hospital, I lost 15 pounds, all of which was mostly muscle. And there were many, many months where I was convinced, I was using bands. I mean they had me doing bodyweight exercise and then bands and then I could finally graduate to using weights. And the one thing my trainer said, because at that point I was coming back from a long hospitalization. I did hire a trainer because I didn't want to hurt myself. I remember him saying, "You're at an advantage. Although you've lost a lot of your muscle mass, your muscles once they start growing again, they'll know what they need to be doing." 

I encourage everyone to-- if you're not currently lifting or doing weight training, even if you start with bodyweight exercises and then graduate to bands and graduate to dumbbells and graduate to get to a point where maybe you're using machines, really take the time to be thoughtful about understanding the physiology of your body. I don't believe in having regrets, but I do wish someone had talked to me in my 20s and 30s about the fact that when you're at your peak bone and muscle mass, and then you just start to have this slow, slow decline that you may not even be perceptible for a long period of time. And men go through this too. Let me be very clear. Andropause is a real thing.

Men, much like women, they may not have as exaggerated demonstration, women go through reverse puberty, that's essentially what's happening in perimenopause. Men can go through andropause and they may have trouble maintaining muscle, they may have trouble building muscle. Most of the reason why men in the States start losing testosterone is from exogenous sources of estrogen mimicking chemicals, also from insulin resistance. Again, we go back to the same things about maintaining metabolic flexibility, how important that is, that I'm sure for those of you that are familiar with both Melanie and my single podcast, we talk a lot about toxins, we get exposed to our environment, our personal care products, our food, it is important, you do want to care about those things. But maintaining muscle mass is of particular significance. And if you're not currently lifting, you can change that. If you start off really simply, it can make such a big difference. 

The one thing that I found working in hospitals for over 20 years, there's nothing more sad than having a 55-year-old patient that can't get off a bedside commode because their muscles in their quadriceps, which are their big muscles in their legs have atrophied from lack of use. If you don't use it, you will lose it. And that's why I think it's so important to understand that we're not saying this is just related to aesthetics, we're just saying from a functional perspective, you want to be able to get out of bed, you want to be able to get off a toilet, you don't want to fall, fall risk is significant. You don't have to be 60, 70, or 80 years old to be at a fall risk. We had plenty of younger patients that were just so sedentary that they had really lost their muscle mass, they didn't even realize it until they got to the hospital and they were so weak, they just couldn't do normal, we call them ADLs, activities of daily living, and this is quite significant.

Scott Emmens: Yeah, absolutely. I can relate to that on two personal notes. First, at 52, I feel like I might be hitting andropause. Is that a real term?

Cynthia Thurlow: It is a real pause. It is a real term, but it's not utilized as openly probably as menopause.

Scott Emmens: It's getting more difficult for me to maintain muscle mass, but to your earlier point, two things. One, on a humorous note, you work out for 15 years, you put on 30 pounds of muscle, you spent 13 days in the hospital, and bam, you lose 15 [chuckles] pounds of the muscle like that. It's not quite fair on the working, how fast you lose that. But that goes to show you that if you're not maintaining it through diet and exercise and supplementation, you're going to lose it, just naturally. So, I do feel that. In fact, since we started working on this project together, I've been up my dose of creatine, I used to take every other day when I worked out. Now I'm taking it every day. I've actually seen a difference in about just the last couple of weeks. That's been nice. But my dad who is--

Cynthia Thurlow: [crosstalk]

Scott Emmens: Thank you. My day who is 74, this was four years ago, we went to Lake George, and we were at my uncle's house and he couldn't get out of the boat. I had to literally pick my dad up out of the boat. And I took my dad in the house and then we chatted as well later that night, I just sat him down and I said, "Hey, we're going to have to get you working out again because if you can't get out of a boat by yourself, and you're living on your own, I'm nervous where you're heading." I didn’t even call it sarcopenia but I said muscle wasting at your age is the first sign of you kind of going downhill. I know what your life goals are. And at 74, you shouldn't be not able to get out of a boat. And now he's on the Stairmaster doing an hour and a half a day, and I'm thinking he's doing better than I am. So, I'm really proud of him but I saw that firsthand at 74, he's in better shape at 78 than he was at 74.

Cynthia Thurlow: It just goes to show you that you don't have to be 20 and still see benefits from weight training and physical activity. We are designed as human beings to be active. I unfortunately, probably not our listeners, but looking at the general population here in the United States, people are far less active than they should be. It's almost like a domino effect. I'd plenty of cardiology patients that they would say, "It's too hard to get back in the game." One thing that I will share with the listeners is that, low testosterone and so that can happen in perimenopause and menopause. It can happen to men as well. It's important to know that a sign of low testosterone is a lack of motivation, a lack of desire. 

Last year, I was on a full complement of hormone replacement therapy and we found that I was on like way too much and so we stopped it. I had a six-week washout. You can imagine you go from feeling pretty good to then feeling pretty bad. I remember talking to Gabrielle Lyon and I said, "I can tell my testosterone is low because I have zero motivation to go to the gym, which is not me. I have zero motivation to do these things. So, I had to really just force myself to do it. But I want to just identify and be fully transparent and say that that can be a sign your testosterone levels are low if you're really feeling incredibly unmotivated." This also ties into one other benefit of creatine use that I think is really interesting. And we're looking at a study that it talked about, as an example, depression is not vis-à-vis, it's related to many factors, gut health, situational circumstances, etc. But we know that depression in women is two times higher. We know it's directly linked to hormone milestones like puberty. 

I have two teenagers, trust me when I tell you, they are grumpy and moody. It's also linked to menopause. What's interesting is that if you have a low creatine intake, either from diet or supplementation, you're at 31% greater incidence of depression than those that are taking exogenous creatine supplementation and/or getting it from animal-based protein. I thought that was really interesting, especially coming off the tail end of the past two and a half years. We won't mention what's been going on, we're all quite aware of it. But I think for a lot of people just also understanding that there's also this mental health benefit from creatine use that keeping adequate levels of creatine endogenously in the body is intricately interwoven with depression and anxiety as well.

Scott Emmens: That really struck me, was not only is it good for your cognition, your focus, but your mood as well. It seems to have from this early data we're looking at, some significant enhancement on your overall mood, motivation, and really depression, which is interesting. I'm not sure if there was a mechanism action identified in that but it's just remarkable how important creatine seems to be for your overall mental health.

Cynthia Thurlow: There was also some research I read about BDNF, so brain derived neurotrophic factor, which we know is a stimulatory protein, it diffuses across the blood-brain barrier, but we know that it increases new brain cell production. So, it's increasing neuroplasticity, while improving the performance of existing brain cells. And so higher BDNF is a lower risk of depression. So, I wonder if it's tied into that. It's interesting how just the process of aging and stress can decrease BDNF, especially those that are not actively learning your skills or hobbies. We're going to touch on neuroplasticity here but this is why you were going to be lifelong learners. We should always be learning. I just spent the weekend with one of my college roommates and we had an amazing time, and she's a teacher, and we were talking about this. She was saying even in like her own teaching population that she said those that are still continuing to take classes and learn are thriving, and those that are kind of at the standstill, colleges 30 years ago, and they haven't really taken-- they don't do continuing education, they're not investing in conferences, they're not listening to podcasts, they're not reading books, and how that's impacting their brain health. This just validates that aging and stress can impact BDNF. We also know that creatine in and of itself vis-à-vis can improve BDNF levels as well in the body. So, it's neuroplasticity, learning new things, exogenous supplementation can also be beneficial for brain health. 

Scott Emmens: Yeah, I'm obsessed with BDNF. Everything that I think can raise brain derived neurotrophic factor. I figure, "Well, how can that possibly hurt?" And exercise is one of those things. Again, we're back to a positive circle up. If creatine helps you get more motivated, helps you get better exercise, you get more exercise, we know exercise is good for BDNF as well. So, it's sort of a nice cycle upward instead of the cycle down. Lack of exercise is going to lower your BDNF, lower creatine is going to lower your BDNF. Again, this is a nice way to think [unintelligible [00:43:59] cycles down, how can you cycle up and the way that you do that, you take creatine which helps you exercise, which helps BDNF, which helps you exercise and helps BDNF. 

Just a quick aside, there was a recent study that came out as an avid tennis player, I have to mention this, they showed that tennis both extended your lifespan, but the longest of all sports, but also had the best impact on your overall brain health because it's both a sport of strategy, at the same time you're running around the court, but it also applied to pickleball for those of you who are getting into pickleball, which is the new rage. Even works in ping pong. Ping Pong had a really positive effect on the brain. So, you're looking for some exercises to help with your brain. Paddlesports, badminton, tennis, pickleball seems to be the best.

Cynthia Thurlow: Yeah, it's really interesting how important I think it is for people to be either it's the hand-eye coordination or just the concentration, but doing things that make you a little-- when I say uncomfortable, I'm not talking physically uncomfortable per se, but just intellectually, like pushing yourself, learning something new, getting outside your comfort zone. I have a friend that's learning, I don't know why she wants to learn a language. Someone in one of my group programs, who thinks she loves to do puzzles for that exact reason that she wants to push herself outside our comfort level. I was actually mentioning to my husband, he just started doing Brazilian jiu-jitsu right before the onset of the pandemic. He was a college athlete. Now that we're in a new part of the state, he is unable to play seniors level lacrosse. 

For him, he said, "It's like playing chess." But he gets to roll around on a mat with-- sometimes guys that are like 20 years younger than him, but he can hold his own and of course you know he is a former college athlete, he loves that. He gets that validation that he's still strong and virile. But I think for each one of us, we have to find ways to constantly be challenging ourselves. I think, on a lot of levels, we're just so fortunate to be in a time where information is accessible at any point in time. I have a large stack of books. I'm always reading. I'm always prepping for podcasts, but I haven't heard a lot about pickleball. I don't know how it differentiates from tennis, and I don't want to take like a huge rabbit hole jump. But I'm just curious how different is it than tennis, I know it's with a racket and a ball.

Scott Emmens: It's kind of if you were to combine ping pong and tennis and put yourself on the ping pong table, that would be the best way to describe that.

Cynthia Thurlow: Interesting. 

Scott Emmens: It's a lot less running and a lot more about sort of teamwork and strategy usually playing doubles. And it's just so much fun because it's fast paced and you get crazy wild points. It's just a lot of fun, but it's a lot of good exercise too without having to run all across the court. If you want to learn pickleball, it's the sport to get into. It's the fastest growing sport in America.

Cynthia Thurlow: I'll definitely have to check it out because my husband and I will be empty nesters in four years. For us, we're looking for all sorts of ways to do things together and new things together. Let's talk about some of the age-related changes that happen in our bodies and how creatine can potentially be a countermeasure to changes in muscle and bone strength. It can be implicated in reducing inflammation and oxidative stress. I did see a couple articles talking about improvement in bone reabsorption. But when I went down that rabbit hole, I didn't feel the strength of the research was strong enough to be able to say this is an indication per se. Maybe in the future, we'll hear more about it but I do think in particular for people in menopause, andropause, where we are de facto in a state of chronic low-level inflammation, sometimes high-level inflammation if we're insulin resistant and metabolically unhealthy, but how creatine can be beneficial for these specific timeframes.

Scott Emmens: Let's quickly address the bone issue. So, I went down the research rabbit hole on bone and couldn't find anything specific for creatine that was definitively positive. I think the reason for the mixed results, and this is just my personal opinion. But, again, I think it goes back to, if you're able to lift heavier weights or use heavier bands, really what we know for sure is that if you're putting weight on your skeletal system that can tolerate, it's going to stimulate proper bone growth given you have the right nutrition. I think what creatine can do is by making your muscles stronger, allowing you to lift heavier and heavier weights under the guidance of professional trainer and [unintelligible [00:48:34] hurt yourself. That, I think, in and of itself could be the way that creatine could help with bone. It may not be a direct result. It may be an indirect result of creatine. It's just a theory because I couldn't find anything definitive in the research.

Melanie Avalon: Hi, friends. I am so thrilled to announce that my next AvalonX supplement is official and almost here. It is something that I currently take every single day of my life and that is berberine. I first started taking berberine when I first started using a continuous glucose monitor which constantly monitored my blood sugar levels. I found that taking berberine had a dramatic effect on my fasting and post meal blood sugar levels. Berberine is a plant alkaloid which has been shown to rival Metformin when it comes to reducing blood sugar levels without any of the side effects. Blood sugar regulation is so important for health. It's a key factor in metabolic syndrome and preventatively taking care of your blood sugar levels or treating high blood sugar levels is so, so important for health and longevity. That's why I am thrilled to be making a berberine supplement. And it's not just blood sugar control, berberine has been shown to have so many benefits. It's been shown in studies to beneficially modulate adipose tissue. It can actually help change the composition of your fat to a more healthy profile. Think less visceral fat, which is the inflammatory fat found around our organs. 

It's also been shown to have beneficial effects on PCOS and reductions in inflammation and is a potent stimulator of autophagy, which is one of our favorite things. Berberine has also been shown to have a beneficial effect on blood lipids, which is huge, and I wanted to make the best berberine on the market. We looked so hard to find a source of berberine that tested to be high potency and free of pesticides. Yes, we did third party lab testing on our source, as well as testing to assure its quality. It is tested multiple times for toxins including heavy metals and mold, and has no problematic fillers. It also comes in a glass bottle to help prevent leaching of plastics into our cells and the environment. This is the berberine that you want, I promise. And it is coming midnight of Friday, December 16th. To get all of the updates about it, definitely get on my email list that's at avalonx.us/emaillist, we'll be announcing the launch special on that list. 

You can also get text updates and a 20% off coupon by texting AVALONX to 877-861-8318. By the way, if you would like to get a CGM to monitor your blood sugar levels and see just how berberine is affecting it, you can get $30 off on NutriSense CGM at nutrisense.io/ifpodcast with the coupon code IFPODCAST. If you'd like to get any of my other amazing supplements at avalonx.us use the coupon code MELANIEAVALON to get 10% off sitewide at avalonx.us. You can also use that coupon code MELANIEAVALON to get 10% off sitewide and my fantastic partner MD Logic Health. For that, go to melanieavalon.com/mdlogic.

Cynthia Thurlow: Yeah, I was the same. I went down that rabbit hole and I wanted it to be true. But I didn't feel like the research was strong enough to say this is an indication per se. But I would agree with you that someone that's going to work diligently about building maintaining muscle is very likely getting improvement in their bone health. One thing I just want to interject is that our bone building accelerates in puberty and then it plateaus. And then interestingly enough in andropause and menopause, but I can speak more specifically to women because I'm more familiarized with the research. What starts to happen as our bone diminishing activity starts, osteoclastic activity up regulates, which means we're actively breaking down bone as opposed to building bone. And that's why women in many ways are at greater risk for osteopenia, osteoporosis at that time in their lives. Obviously, osteopenia is kind of a lack of a better way to put it, it's a diagnosis that was created by the pharmaceutical company, it's really not a diagnosis per se because they're comparing the bone tensile strength of a 50-year-old to a 20-year-old and you can't compare that great of a difference in age. Osteopenia, I don't get terribly concerned about but obviously osteoporosis is significant, and really does need to be addressed proactively.

Interestingly enough, one thing that kind of accelerates a lot of these processes in the body in women is that as we have lower and lower estrogen level, so tail end of perimenopause because in menopause, we can have very high estrogen levels prior to going into menopause, is that this is what really drives inflammation, it drives the oxidative stress, it drives the degree of insulin resistance. And it also blunts muscle protein synthesis, and also satellite cell response to anabolic stimuli, which is a fancy way of saying strength training. It's not in your head. If you find that in perimenopause and menopause, it is a lot harder to build muscle, you are working against hormones. The hormones that are saying, "There's not enough estrogen around." Estrogen is definitely one of these hormones that we have estrogen receptors throughout our body, but directly impacts this muscle-protein synthesis, and so it is not in your head if you're struggling to maintain and build muscle. Estrogen and testosterone can definitely play a role in that.

Scott Emmens: The power of hormones is undeniable. You feel it when you go through menopause, you feel it when you go through andropause, you see it when people take artificial steroids. If you look a gentleman or woman on steroids, you can tell, at least I can tell. They're very powerful. People also underestimate the power hormones on your mental cognition as well. A lot of effects on your mentality, as you're alluding to earlier about when your testosterone lowered, you'd have no motivation. You think that's in your head, but it's not. It's a hormonal issue.

Cynthia Thurlow: Exactly. The Women's Health Initiative is a study that I definitely talk about on the podcast, but in 2002, the Women's Health Initiative really changed the narrative and the comfort level of clinicians prescribing hormone replacement therapy, made many, many patients scared. There's no other way to put it. Scared to take hormone replacement therapy. I did a really great podcast with Dr. Avrum Bluming and Dr. Carol Tavris talking about this. He's a clinician, he's a physician, he's an oncologist. She's a researcher and they really debunk the Women's Health Initiative. Unfortunately, it was done on an older population of women, they already had insulin resistant, they were former smokers or current smokers, they had high blood pressure, a lot of health issues, and they put them on synthetics, and then drew conclusions from that. I always like to just interject, there's no judgment, there's no shame. I see a lot of women who are fearful to take hormones and so they're white knuckling it into perimenopause and menopause. Each one of us has to make a decision. This applies to men as well. Each one of us has to make a decision that makes the most sense to us. But understanding that hormone replacement therapy can be very beneficial, in particular for muscle and bone and brain health, and cardiovascular health, etc.

Scott Emmens: I've heard that podcast and I paid very close attention because I was in the pharmaceutical industry in 2002 when that study came out, and I was partnered with Eli Lilly, I think they either funded this study. They were making a product for hormonal replacement therapy for osteoporosis is what it was. And doctors stopped using it and folks frenzy and I read that study, then I thought, "This seems awfully skewed." It's 20 years later and just the other day, I kid you not, I heard people talking about that study in a negative light, which is a lot what happened to creatine, what are some of the common misconceptions. People thought, "Well, it's bad for your kidneys, it's bad for your heart," and had all this negative press going into it. But that stuff is 20, 30 years old, it's been one of the most studied supplements there is. It's interesting that you use that study because this is tantamount to that like, this is one of the best things you could do. That study sort of ruined HRT for a lot of people, which is a shame.

Cynthia Thurlow: Absolutely, because there's a whole generation of women. I think about my mom's generation that have really suffered needlessly because they were told that it was going to give them cancer. We've now figured out that that's not actually the case. But let's sling back to sleep and sleep deprivation. The reason why I think this is particularly important, we get a lot of questions on the podcast about sleep. We know that high stress, chronic stress will actually deplete not just creatine stores, but actually ATP. So again, less energy circulating. And we know that supplementation with creatine based on the research that we've both been looking at, can impact tasks that rely on the prefrontal cortex, which is our executive functioning brain, the one that helps with cognition and attention and memory, very important. Also very important because we know women are more sensitive to sleep deprivation, and particularly women that are most at risk, or the women that are pregnant, breastfeeding, postpartum, and menopause.

Based on this research I was looking at and I thought that was really interesting, because for any woman that's listening that went through pregnancy and then had the postpartum period where you weren't sleeping for weeks or months on end, that's pretty harrowing, but also in the same research article, they were talking about menopause as the same degree of sensitization to sleep deprivation. I think a lot of women that are listening or women know of other women who have spent years of having terrible sleep deprivation in middle age both in perimenopause and menopause, and it's totally normalized. I think that's really, really unfortunate.

Scott Emmens: It is and there was actually a study, I don't know if it was one of the ones you have had send me or one that I had read separately, that talks specifically about creatine's ability to support brain fatigue and sleep deprivation. I wouldn't call that a band-aid, what I would call that is going to allow you to get the energy you need to function throughout your day properly, so that when you do go to bed, you're back in your rhythm because one of the things that we know about sleep is it's all about your rhythm, your circadian rhythm, your exposure to light, your lack of exposure to light in the evening, your cortisol spikes and peaks amongst other things, but sleep is a lot about rhythm. If you don't have enough energy during the day, and you're resting all day, and you're sitting down all day and you're not active, well then what's going to happen at night, is you're going to kind of be that wire-tired mode, you're exhausted, but yet you're tired. 

The information I looked at really said, "Hey, look, if you're in this sick deprived state, not only can it help you get out of it, and really help your brain heal itself and be as active as it was and it gotten that sleep." To me, that's a way to reset your circadian rhythm at least your energy circadian rhythm, and then you've got to do other things obviously to support that.

Cynthia Thurlow: I think it's really important. And it's something that I didn't realize until I was looking at the research that what has been different over the last couple months, in particular, because I've been taking creatine consistently, was my sleep quality is improved and how do I track that? I track that on my Oura ring? And then I probably will screenshot it and share it in IG stories and people say, "Oh, my gosh, how did you get that much deep sleep?" And I'm like, "I think it's a couple things." But I keep trying one thing, pulling that out, trying something else because sleep in many ways becomes an art form. And I don't think I ever thought about sleep to the degree that I do now. But knowing that potentially the creatine I've been taking has been improving that sleep support, which again I think most, if not all women, and men for that matter, would truly desire to have better quality sleep.

Scott Emmens: Yeah. I've been a chronic insomniac pretty much my whole life. Recently, I've been sleeping pretty good. Got the whole system down. I do the light in the morning, try to keep it dark in the evening, creatine, occasionally I'll do melatonin when I feel I just need to reset my clock. But I've been doing really well. I'm getting up at the same time every morning, going to bed at the same time every evening. And I have been taking creatine now for a couple of weeks almost every day.

Cynthia Thurlow: That's great. Well, probably important to talk about where we can get food sources of creatine. And then talking about dosing because I think that will be a huge question for many people. How much do I need? I'm carnivore-ish, do I really need more? The answer is yes. But what are some of the sources of animal-based protein that are most creatine dense, I guess is the way to put it.

Scott Emmens: It's going to be all of your essential meats. It's going to be steak, in turkey, things of that nature. I don't think fish has a ton, but it has more than that. But basically, the really only place you're going to get creatine in your diet is from various meats. So, it could be pork, it could be yak, it could be bison, but meat is really going to be the only substantive way to get it into your diet. Eating meat, you're going to really be at risk for being low in creatine. If you're a vegan or vegetarian, especially if you don't eat any fish, you're going to be at serious risk of a major creatine deficiency. Even if you're eating meat, there's not really enough per kilogram if you look, it's like, I don't know, I can't remember the exact numbers, maybe you've got it at your hands. But it's something like 0.8 milligrams per kilogram of meat. Well, the kilogram is 2.2 pounds. I don't eat 2.2 pounds of any meat. So, there's not a ton of creatine going in. And the data I looked at says that average woman stores about 100 grams of creatine and excretes a net 2 or 3 grams a day. Men hold 120 and excrete about 2 or 3 grams a day as well. So, you're always in this negative deficiency unless you're eating enough meat to compensate for that. 

When it comes to the dosing, for me it's somewhere between 3 and 5, or 3 and 6, or even I'd even go to 9 if I felt like I needed some creatine because I hadn't had meat in certain period of time. But I think it is dependent on what your diet is like, are you vegan? Are you a carnivore? Athlete? Like, for example, my daughter is a Division I track athlete and she runs the 400 meter, the 100 meter hurdles. No, that is a lot of energy. She's got three-hour practices every day. So, I've got her on 9 milligrams of creatine a day, broken up into three doses, one with breakfast, one with lunch, one with dinner. My [unintelligible [01:03:46] actually like to take 9 milligrams all at once. I don’t take 9, I usually take 3, 3, and 3 or 5 and 5. I like to break it up. I have her just on 3, 3 and 3. And that changed her trajectory because in high school she wasn't the star of the team. We put her on creatine, some amino acids, but this was the only thing, she practiced and trained with a lot of other things but she ended up finishing 100 meters [unintelligible [01:04:14] in Pennsylvania, six in the entire state of Pennsylvania. So, was it creatine? No, not alone, but did that help? Yeah, I bet you that helped.

Cynthia Thurlow: That's an incredible story. I think it's important for people understand that the average person listening could probably get away with 3 grams per day. Like Scott mentioned, his daughter's a Division I athlete, totally different. Needs based on research that we looked at, the vegetarians and vegans need probably 5 grams a day. And so just understanding that very athletic people, and by that, I mean ultra-level conditioned athletes. I'm not talking about person who does CrossFit twice a week. Although that's great, you're probably not the person that needs that high amount of creatine. And also, it's interesting depending on where a woman is in her menstrual cycle, she may need more or less. But we didn't want to get terribly nuanced about that because there're so many other factors that impact hormone regulation and insulin sensitivity throughout a menstrual cycle. But just understanding that 3 grams a day has been our recommended for the average person that includes myself. But certainly, if I were giving this to my very athletic, sports-oriented kiddos, it would probably be more because they're still growing.

And, obviously, if you are vegetarian or vegan, your creatine needs, because you're not eating animal-based food or products, is going to be higher. And what was interesting, and I just want to make sure I'd dovetail this into our discussion about vegetarianism and veganism, is that it was even discussed in some of the research that their needs for creatine just based on brain health or even higher because they're not getting those animal-based products. And we respect people's choices. I just wanted to make sure I mentioned that they have to take more creatine to ward off the brain health related concerns.

Scott Emmens: Yeah, absolutely. I think we all make our individual choices. We obviously respect those choices. But it is important for people to know when they make any choice, whether it's to eat meat, what those risks are, or to not eat meat, what that diet will require you to do. Like we know, most vegans know that vitamin B12 is an essential supplement. I would put creatine in that same bucket. If I were vegan, there's no question I'll be taking creatine. I take it anyway I'm not eating because I know I'm excreting a little more than I'm taking in. I can feel the difference. But for sure, if you're vegan, you're going to want to, at the very least you do some research on your own, talking to physician or a functional medicine specialist, and I think you'll find that creatine will be a great addition to your diet.

Cynthia Thurlow: Absolutely. Well, I want to make sure I'm respectful of your time because I know that you have a lot going on as well. This has been an incredible podcast. I hope listeners find it to be just super information savvy. A few things for listeners before we go. If you'd like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can follow us on Instagram, we are @ifpodcast, I am @cynthia_thurlow_, Scott is @longevityprotocol, and MD Logic is @mdlogichealth. The show notes for today's episode that will have a full transcript as well as links to everything that we've talked about will be at ifpodcast.com/episode292. You can get all the stuff that we like at ifpodcast.com/stuffwelike.

This has been wonderful, and we will see you next week. And before we go, I wanted to make sure that I also included the link to get on the waitlist for my creatine. It's cynthiathurlow.com/new-shop/creatine. Gosh, that wasn't made easy, was it? Got to make things complicated. I'll tell my team make it easier next time. Scott, is there anything that you want to add before we go?

Scott Emmens: Well, yes, I would like to add that I have your updated information and the product by the time this airs, I think is November 21st, that the creatine will be available for purchase on November 21st. So, if you are not on the list already, you can order. It should be able to be ordered through your site, Cynthia, on November 21st.

Cynthia Thurlow: That's super exciting. I feel like this has been many months coming to fruition and I can't wait to share with the listeners the next product we're going to be working on.

Scott Emmens: I can't wait either. This has been great. Thank you so much for having me, Cynthia.

Cynthia Thurlow: Awesome. This has been so wonderful, and we will see you next week.

Scott Emmens: All right. Take care.

Melanie Avalon: Thank you so much for listening to The Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team. Administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs. And original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription] 

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Oct 16

Episode 287: Thyroid Mysteries, Functional Medicine, Gum, Oral Microbiome, Halitosis, Electrolytes, 48 Hour Fasts, And More!

Intermittent Fasting

Welcome to Episode 287 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/ifpodcast To Get A FREE Sample Pack With Any Purchase!

AUDIBLE: This is Melanie's well-known secret for reading #allthebooks #allthetime! Audible provides the largest selection of audiobooks on the planet, in every genre! With Audible, you can listen on any device, anytime, anywhere! Every month, members get 1 credit to pick any title, unlimited Audible Originals, access to daily news digests (The New York Times, The Wall Street Journal, and The Washington Post), guided meditation programs, Audible Sleep, and more! Audible provides rollover credits, easy exchanges, discounts on titles beyond credits, and audiobooks you'll keep forever! For those with children, check out the free Stories.Audible.com! Go To audible.com/ifpodcast Or Text IFPODCAST To 500-500 For A 30 Day Free Trial, Including A Free Audiobook!

 JOOVV: Like Intermittent Fasting, Red Light Therapy Can Benefit The Body On So Many Levels! It Literally Works On The Mitochondrial Level To Help Your Cells Generate More Energy! Red Light Can Help You Burn Fat (Including Targeted Fat Burning And Stubborn Fat!), Contour Your Body, Reduce Fine Lines And Wrinkles, Produce Collagen For Epic Skin, Support Muscle Recovery, Reduce Joint Pain And Inflammation, Combat Fatigue, Help You Sleep Better, Improve Mood, And So Much More!! These Devices Are Literally LIFE CHANGING!! For A Limited Time Go To joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount!

To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

LMNT: For A Limited Time Go To drinklmnt.com/ifpodcast To Get A FREE Sample Pack With Any Purchase! Learn All About Electrolytes In Episode 237 - Our Interview With Robb Wolf!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

The Melanie Avalon Biohacking Podcast Episode #165 - Dr. Karen Becker

Go To yummerspets.com And Get 10% Off Sitewide With Code MELANIEAVALON!

How She Grew Pre-Sale! 

AUDIBLE: Go To audible.com/ifpodcast Or Text IFPODCAST To 500-500 For A 30 Day Free Trial, Including A Free Audiobook! 

Listener Feedback: Knowles - Thank you!

Listener Q&A: Sandra - Please help me!

Unfunc Your Gut

Listener Q&A: Tracy - Gum

The Melanie Avalon Biohacking Podcast Episode #162 - Danny Grannick (Bristle)

Ep. 153 – Fix Your Mouth/Fix Your Health: Reversing Tooth Decay Naturally with Trina Felber

Primal Life Organics!

JOOVV: For A Limited Time Go To Joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount!

Listener Q&A: Anna - Fasting, electrolytes and hot, humid weather

Ep. 213 All About Electrolytes: Symptoms, Causes, and Solutions for Electrolyte Imbalance with Robb Wolf

Simply Hydration!

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 287 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this podcast do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time and get ready for The Intermittent Fasting Podcast.

Hi friends, I'm about to tell you how you can get my favorite electrolytes for free. Yes, completely free. And the feedback we have received about LMNT electrolytes from our audience is overwhelming. You guys love LMNT and I'm so excited, because our new offer allows new and returning customers to get free LMNT and on top of that their super popular Grapefruit flavor is back. If you've been having issues with intermittent fasting, electrolytes may just be the thing that you need and/or have you heard of something called the keto flu? Here's the thing. The keto flu is not actually a condition. Keto flu just refers to a bundle of symptoms, headaches, fatigue, muscle cramps, and insomnia that people experience in the early stages of keto dieting. Here's what's going on. When you eat a low-carb diet, your insulin levels drop. Low insulin in turn lowers the production of the hormone aldosterone. Now, aldosterone is made in the kidneys and it helps you retain sodium. So, low aldosterone on a keto diet makes you lose sodium at a rapid rate. And even if you are consciously consuming electrolytes, you might not be getting enough. In particular, you need electrolytes, especially sodium and potassium in order for nerve impulses to properly fire. Electrolytes can easily be depleted while intermittent fasting.

Robb Wolf, who as you guys know is my hero in the holistic health world, worked with the guys at Ketogains to get the exact formulation for electrolyte supplements to formulate LMNT Recharge, so you can maintain ketosis and feel your best. LMNT Recharge has no sugar, no coloring, no artificial ingredients, no junk. They're used by three Navy SEALs teams, they are the official hydration partner to Team USA weightlifting, they're used by multiple NFL teams, and so much more and we have an incredible offer just for our listeners. You can get a free LMNT sample pack that includes all eight flavors. Citrus, watermelon, orange, raspberry, mango chili, lemon, habanero, chocolate, and raw unflavored and the raw unflavored, by the way, is clean fast friendly. You can try them all completely free when you make a purchase at our link, drinklmnt.com/ifpodcast. You can get this offer as a first time and as a returning LMNT customer and I know there are a lot of returning LMNT customers. The feedback I hear from you guys, "loving LMNT" is amazing. LMNT offers no questions asked about refunds on all orders. You won't even have to send it back and this offer is exclusively available only through VIP LMNT partners. You won't find this offer publicly anywhere else. So, again, the link is drinklmnt.com/ifpodcast and we'll put all this information in the show notes.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat but do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream and then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup maybe playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies, when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years. 

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later, maybe half of that lead has left your bones. On top of that there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on and friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their overnight resurfacing peel and vitamin C serum every single night of my life and their makeup is amazing. Check on my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out and you can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well. 

And lastly, if you're thinking of making clean beauty and safe skincare, a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like the Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order and we'll put all this information in the show notes. All right, now, back to the show.

Melanie Avalon: Hi, everybody and welcome. This is Episode number 287 of The Intermittent Fasting Podcast. Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, Melanie, how are you?

Melanie Avalon: I am good. Can I tell you the crazy hurricane story?

Cynthia Thurlow: Yes, please do.

Melanie Avalon: Oh, my goodness. So, at the time of this recording, Hurricane Ian just happened a few days ago and my family has a condo in Sanibel Island, where it basically landed in Fort Myers, Sanibel Lee County right in that area and they didn't know it was going to land there until-- The county didn't do a mandatory evacuation until 24 hours before, because they thought it was going to hit Tampa. Were you following it, the hurricane? I know you're crazy traveling.

Cynthia Thurlow: Yes, I've been following it because I was initially concerned obviously about all my friends impacted in Florida but I was also concerned I might not make it back from the West Coast. So, we had a very, very turbulent last 30 minutes of my flight on Friday.

Melanie Avalon: Oh, wow. Yeah, I bet. I didn't even think about that. 

Cynthia Thurlow: Yeah, and it's interesting as soon as we got on the plane, the two pilots were former Air Force pilots that had transitioned to the civilian sector and I jokingly said to the person sitting next to me, I was like, "I feel complete confidence because they have dealt with far worse than the impact of Ian coming up the coast." So, lots of turbulence, more than I've had in a long time but we safely landed and I'm grateful to have gotten home on Friday.

Melanie Avalon: Random quick sidenote about planes. When I flew to Austin on the way back after we landed, they told us that-- Basically, they were like, "Congratulations, we were actually testing autopilot to land and it was a success." And they tried to phrase it like it was like congrats and everybody on the plane was like, [laughs] "Is that a good thing?" I told my family and they're like, “We have never--” "Have you experienced that on a plane after the fact they tell you that?”

Cynthia Thurlow: Well, I think there are probably a lot of things just like when I worked in healthcare that go on that you have no idea is going on behind the scenes and then you just blissfully and naively get off the plane and you're like, "All is good." In the past week, I've been up and back to New York and then across the country to LA and back, and one of the legs of my flight, I think it was Denver to LA, there was some type of "dent" in the side of the airplane and so, we had a 90-minute ground delay while maintenance determined if it was "safe to fly." So, it was one of those things where I was like, "Dang, I don't want to not fly today." But obviously, safety is of the utmost importance and so we ended up flying without any issues but it was funny how they were talking about this dent and I'm thinking, "Is it a big dent, a little dent?" They didn't identify how large or small it was, but I'm grateful someone was paying attention.

Melanie Avalon: Wow. I remember my piano teacher growing up, she said one time on her flight, they were flying and then they didn't land. They were just circling and they told them it was because they knew something had fallen off the plane, but they weren't sure what it was. [laughs] So, then they found out later it was a hubcap to the wheel. So, it was fine. But can you imagine--?

Cynthia Thurlow: No, I can't. Sometimes, again, it goes back to that being somewhat blissfully naive to the interworkings of aviation is probably to my benefit, because I think both of us are probably very similar. I'm such a critical thinker. I'd be like, "What impact would that make? Would that impact drag on the plane? What would go on?" And I made the mistake of watching-- Anyone that's listening, don't watch the documentary about Boeing.

Melanie Avalon: Wait, wait, wait, is that the one where the pilot got sucked out the window? 

Cynthia Thurlow: No, this was about how Boeing was bought out and their safety and maintenance strategies changed enormously when they were bought out. And then there were two major airline disasters. I was saying to my husband, I was like, "Why did I--?" Because I tend to be a documentary nerd anyway and I was like, "Oh, I started to watch it." And then I was like, "I probably should not be watching this on a plane at the same time." Probably, not a good idea. Yeah, it wasn't about anyone getting sucked out but there were two major crashes in the late 2018, 2019 that were related to Boeing not wanting to properly train the pilots in this system that was helping the plane, like stayed kind of equal. Again, I'm not a pilot so I'm probably not explaining this properly, but there were some technical things that had changed about the newer planes that Boeing did not disclose.

Melanie Avalon: Wow, the pilot sucked out one scarred me for life. The window broke, literally the pilot got sucked out the window. I don't even know the details. I have to rewatch it. It was some United flight. But then the crazy thing is, they landed the plane because of the oxygen levels dropping from the window, it made the pilots be at the level of being drunk. They landed the plane successfully and the pilots survived. They've been holding on to him and he was outside the window, scarred me for life.

Cynthia Thurlow: Those were some good friends.

Melanie Avalon: I know. In any case, the hurricane. My mom had decided to stay on the island. My sister had evacuated and the night before it hit when we all realized it was going to hit the island, she was wanting to drive back after all, mostly, because she was worried about the car. My dad's car getting ruined in the garage and we all convinced her to stay, because we didn't want her to leave and get stuck driving in the middle of the hurricane. In retrospect, maybe she should have left because maybe she would have gotten far enough away. In any case, the hurricane hit Sanibel. Actually, I bet a lot of listeners have been to Sanibel, because I've been posting about this and I've been getting so many DMs of people who have been to Sanibel or knew about it. It’s this beautiful-- Well, it was. This beautiful, gorgeous island, 14 miles long, one mile wide, really nice restaurants and no streetlights. Like an old town feel, but really nice. 

So, in any case, that's where the hurricane hit and my mom said, the water-- She was on the third story at the condo. She said the water went up past the garage up to the first story of the condo. We think it was probably about 18-feet high, the water. She actually thought she was going to die. This is so sad. She said she was in the closet because she had our puppy and my sister's cat and she said that she thought she was going to die, and she was writing us all letters, and she put out a lot of food for the pets hoping they would survive. It's so sad. So, that was that night. And then we weren't really hearing from her because the cell signal was so spotty. And then the causeway to Sanibel, it broke. It's gone, half of it. The island got shut off from the mainland, covered in water. We weren't really able to get in touch with her. Most of the boats in Florida are all wrecked. All the ones that were basically on-- Not in Florida, but Fort Myers in that area and on top of that you couldn't even barely get down there. We were trying to find a rescue mission. Literally, all day, it was the craziest day of my life.

I'm friends with Kirk Parsley. I've had him on The Melanie Avalon Biohacking Podcast. He's a sleep doctor and a Navy SEALs. He connected us to this group of military and SEALs that help people with rescue-type missions. You can hire them ala carte to help you with things and they were so nice. The woman in charge, Stacy, shoutout to Stacey. She found us this guy, Captain Dave in Fort Myers who had a pontoon boat and so, the few times we were able to vaguely get a text through to my mom, which on top of that-- Oh, this is a good lesson for people, this might help somebody. If you're in a situation where you don't have good cell service like this situation, if you have your phone, set on iMessage, then you'll have a lot of issues getting through texts because it'll wait for iMessage to be online. Basically, my mom could only text my aunt, because she has Android and she wasn't realizing it was her phone settings. So, we were having to text her through my aunt and we're trying to communicate with her that she had to be on the beach the next morning at 8 AM and wave a signal. We didn't know she was going to be on the beach. It was literally the craziest thing.

And then Captain Dave in his pontoon boat, [chuckles] the next day went across the ocean to Sanibel with two other guys and picked up my mom and three neighbors and rescued them and my sister and brother had driven down the day before, so they picked her up. It's just insane and it's so crazy to see pictures of the island and it's so weird, because my whole childhood was basically there and to know that it's all just gone. It's very, very weird feeling. I'm so grateful. Last I checked, I think, I don't know what the death count is at, I think it's in the 60s, not just Sanibel, but the whole area where it hit. My heart goes out to everybody and it's just a crazy experience. So, I had to share that.

Cynthia Thurlow: No, I'm so glad that your mom was able to be rescued along with some of her neighbors. I have a lot of friends in the Naples area and the photos-- 

Melanie Avalon: Yes, that's where it hit too. 

Cynthia Thurlow: I have friends that left Northern Virginia, and were building houses down there, and they lost everything. They lost their cars, they lost their homes, the photos are just really, really heartbreaking. The irony is, one of my Hopkins nurse friends lives down there and her house was okay, but another friend of mine that I've known for, gosh like 15 years, I was able to connect both of them and I just think for all of us that are so fortunate that we're not adversely impacted by these storms, we owe it to ourselves as community members to try to find ways to help and donate. If you can donate money, donate time, or working with local organizations, because all of us probably know people that have been impacted. My mentor and the head of my mastermind, she actually had to evacuate and I've been at her home and-- [crosstalk] 

Melanie Avalon: Where is she?

Cynthia Thurlow: Tampa. A lot of people just picked up and took their pets and left because they had to. They were so close to the water or live on the water and gosh, there're so many people impacted but in terms of your mom's story, of course, it sounds like an incredible-- This is where networking and podcasting is so helpful. I'm glad that Kirk was able to get you connected individuals that could get her to a safe place and neighbors as well, and pets. Can't forget the pets.

Melanie Avalon: I'm so grateful. Yeah, that's the other thing that I forgot. In the condo, we had hurricane shutters. They actually stayed intact. Actually, the inside of our condo is okay, but almost every single unit, the shutters blew in and it's a situation where basically, the whole wall facing the ocean is window shutters. All the other condo units, they blew in. I can't even imagine if that had happened. But my mom, like she said, she thought she was going to die, because the whole building was shaking. Super grateful. I know from all the DMs. I got that a lot of people had situations, where they had friends or they weren't hearing from people and when we air this it will have been a while ago.

Cynthia Thurlow: I'm so glad that she's safe. I know we were texting over the weekend, and I was crossing my fingers, and grateful to know that there was a happy ending.

Melanie Avalon: Yes, indeed. So, anything you'd like to share before you jump in? I know you've been crazy with travels.

Cynthia Thurlow: Yeah, I've had some really cool professional things. I was able to speak at an event at Lincoln Center and having grown up in New Jersey, Lincoln Center is a really special part of Manhattan, and then I flew out to the West Coast earlier this past week and was on two of the biggest podcasts that are out there, not just in the health and wellness space, but two of the big ones and that was such a surreal experience and they were both incredibly humble, warm, made me feel incredibly welcome. I left hugging both of them and really just feel incredibly grateful. It's such a cool experience. I have a cousin who works at USC, so I got to see him and then some other friends for dinner the last night I was there but yeah, it was a whirlwind week between New York and LA. Literally, it was home for a day and then flew back out again.

Melanie Avalon: I can't wait to personally hear more about it. I know you literally texted me about it the day of operation. What my siblings and I are calling the operation delta-alpha, which stands for a name we've given my mom for her decision to stay on the island. You were texting me all during that, so I didn't really get to absorb it. I can't wait to hear more later about the actual experience because I'm really excited and happy for you. It's awesome.

Cynthia Thurlow: Yeah. Here's the thing. For anyone that's listening, I think vision boarding is really important, because the process of manifestation without going down a gigantic rabbit hole is just such a cool thing. Because one of these people was on my vision board from five years ago. When I was finished recording with him, and I was leaving, and he and his team were wonderful, and I just said, "I have to let you know, you've been on my vision board for five years and I knew one day I would meet you," and this is just such an incredible, incredible experience. I'm so very grateful and appreciative. Then I walked outside and flagged down an Uber [laughs] went back to my hotel. So, yeah, it was really cool. Really, really cool.

Melanie Avalon: Just one comment I love, because especially when you have a career like us, where it's very nebulous, because it's all creative and creating your own path and there's not milestones, per se. So, it's really nice to have those moments, things that were personal milestones. That's amazing. Have you had him on your show?

Cynthia Thurlow: No. I'll have Sean Stephenson on my show in November and I think Lewis is not doing a ton of press right now. He's got a book coming out in 2023. No, I've haven't had him on. That would be a gigantic unicorn guest. 

Melanie Avalon: Yeah. It's amazing. 

Cynthia Thurlow: Yeah. For context, Lewis House is who I'm talking about, but he could not have been more gracious and just how can I help you, very heart centered and very genuine. He's done the work. You can tell it. And yeah, I sit back and complete-- I'm just feeling very, very-- There's no other way to describe it. And I'm a pretty articulate person just sitting in complete gratitude. There's not a lot wrong in the world right now for me.

Melanie Avalon: It's amazing. Well, I have two quick announcements before we jump in. Speaking of pets, I will talk more about this next week, but there's a company called Yummers that I am obsessed with. If you listen to my episode that I aired with Dr. Karen Becker, which is one of my favorite episodes to date on The Melanie Avalon Biohacking Podcast, you will really, truly realize the importance of what we feed our pets and so, Yummers makes amazing toppings for your pets that are completely like everything I would design there. No problematic additives, just healthy, just the good stuff. And the founder is a personal friend and so, I just wanted to share it with you, guys. By the way, I was talking about our cat and dog that survived the hurricane. They love Yummers. So, I do have a link. You can actually get 10% off site wide with the code, MELANIEAVALON. That's at yummerspets.com. Y-U-M-M-E-R-S-P-E-T-S dot com. I'm going to talk about it more at length probably next episode. 

And then second announcement before we jump in. There is a summit coming up called ‘How She Grew.’ It's being hosted by five different influencers but one of them is my dear, dear friend Noelle Tarr, who cohost The Well-Fed Women Podcast. Noelle's one of my bestest friends and I've been listening to Well-Fed Women, which used to be called the Paleo Women Podcast, literally since it started years ago. It's one of my favorite shows and I still listen to it every week. Noelle created ‘How She Grew.’ The purpose of it is for women who really want to learn about creating their own business and just doing something like themselves that out of-- Actually, I don't even know, if it might be traditional jobs as well, but basically they just interview a lot of really successful women. I'm doing an episode. Cynthia might be, we're not sure we were talking before this. But in any case, I think it'd be super, super valuable. So, there is a prelaunch discount. I'm going to make a redirect. If you go to melanieavalon.com/howshegrew-- And then we don't know if Cynthia is doing it. We’ll put in your redirect. It might not be there. Would it be like cynthiathurlow.com/howshegrew?

Cynthia Thurlow: Probably.

Melanie Avalon: Okay. You can try that too. [laughs] But in any case, I think they're going to have the basic one, where you can get just the interviews and I think it's going to be around 199. And then before November 1st for premium access, which will include the videos, lot of bonuses, a Facebook group, lot of cool stuff that'll be $2.27 and then it goes up in price after November 1st. So, snag it now. You can use those two links that we just gave. I really do think it'll be really valuable. I had a really great conversation with Noelle. Ours is sort of focused on podcasting and influencer stuff, but yes.

With my super busy schedule and how I'm always on the go, I don't have a ton of time to do the things I want to do like reading and that's why I love Audible. Audible offers an incredible selection of audiobooks across every genre from bestsellers and new releases to celebrity memoirs, mysteries and thrillers, motivation, wellness, business, and more. Recent favorite is Jennifer Worth, Call the Midwife. As an Audible member, you can choose one title a month to keep from their entire catalogue, including the latest bestsellers and new releases. All Audible members get access to a growing selection of audiobooks, Audible originals and podcasts that are included with membership. You can listen to all you want and more get added every month. My personal favorite way to enjoy Audible is while driving in my car and also, while at the gym. Let Audible help you discover new ways to laugh, be inspired or be entertained. New members can try it for free for 30 days. Visit audible.com/ifpodcast or text IFPODCAST to 500-500. That's audible.com/ifpodcast or text IFPODCAST to 500-500 to try Audible free for 30 days. audible.com/ifpodcast. 

Melanie Avalon: Shall we jump in to fasting stuff? 

Cynthia Thurlow: Absolutely. We've got some feedback and it says, "Thank you, Melanie and Cynthia. I was so surprised to hear my name and question yesterday on the podcast. I really appreciate your in-depth answers and will be relistening to make sure I got it all. We had house guests last weekend and I ate breakfast to be convivial and was starving the rest of the day. I really prefer skipping breakfast and I'm happy to know that I'm not damaging my health by doing so. Thanks for all you do. Fondly, Knowles." Knowles, we're so glad that you submitted a question and we're even more appreciative to know that you found so much value in our responses.

Melanie Avalon: Yeah. And one thing I just like about hearing this back from Knowles is, so, obviously, her issue or her question had to do with really feeling like she had to eat breakfast. That did not suit her life. It made her more hungry. It's so interesting to me that people, because I know I'm this way personally. I struggle with autonomy. I need somebody to tell me that it's okay. This is probably a character trait that I should work on with my therapist. But I find it so interesting that people need to know-- Especially, with intermittent fasting, they just need somebody to tell them that the decision that they intuitively know is okay and right, is okay and right. So, I do want to empower people to feel what they're doing is okay but I like that we cannot provide that service, but that we can help out in that aspect to reassure people that they should listen to their bodies and do what feels right. And if they want to skip breakfast even in a social situation, that is okay.

Cynthia Thurlow: Exactly. And I think the other piece of it is, more often than not, when people are uncomfortable with the decisions that we make for our own betterment or our own self-improvement, it's really a mirror of their own issues and not your own. If people are bothered by the fact that you fast or you don't eat breakfast, feel comfortable and confident that you were doing what is aligned and most in step with supporting you and your body and don't feel you have to over explain yourself. That's the other thing and I don't know if it's life stage of where I am, but I'm definitely in a stage where I no longer feel I have to explain myself. I tried to just be respectful and respond to people's questions or concerns but by the same token, one of the things that I think we as a group of clinicians have not talked to our patients enough about consistently is the value in the power of N of one. Meaning, you as an individual and doing a degree of experimentation to find what works best for you, your lifestyle, etc.

Melanie Avalon: Exactly. I love that. All right, shall we jump into some questions?

Cynthia Thurlow: Absolutely. 

Melanie Avalon: To start things off, we have a question from Sandra and the subject is: "Please help me." And Sandra says, "Hello, beautiful ladies, first of all thank you so much for the amazing work you do with this podcast. I absolutely love it. Love the chit chat, the tangents, the honesty, and your personalities. I'm 29 and according to my blood work, perfectly healthy and yet I have all the symptoms of someone with hypothyroidism. I started IF exactly a year ago on March 14th, 2019 and had great results not only a weight loss, but also in my general wellbeing until this February. In the past one month and a half, I've gained the 25 pounds I had lost. I'm 5'1" and I'm weighing 135 pounds. I know the number on the balance isn't everything, but my pants don't fit me anymore and I feel extremely bloated, heavy, tired, and sluggish. I'm also presenting symptoms of IBS, bloating, abdominal pain, and constipation. I'm a Mexican student living and working in California. I've been to see several doctors including naturopaths and no one seems to know what's wrong with me. All my tests come back normal, but I feel so awful it's hard to function. I really don't know what to do and would love some guidance, advice, and help. Thank you so much. Love, Sandra."

Cynthia Thurlow: Oh, Sandra, goodness, there is clearly something going on. If you have gained 25 pounds in a short amount of time, I think more so than anything, the fact that you sound from what you've described that you sound like classic symptoms of potentially an underactive thyroid. I think that you need to find an integrative medicine or functional medicine doctor, MD, Nurse Practitioner, PA in your area. When people say, everything's normal, that to me sounds very aligned with an allopathic perspective. And so, the reason why I'm encouraging you to not settle with people telling you what's going on is normal. It is not normal because there's some degree of metabolic imbalance that's going on that has precipitated you feeling so poorly and it could be any number of things, which is far beyond the context of this podcast and that's why I think if you go to and I have no affiliation with IFM, but www.ifm.org, you can put in your zip code or your part of California that you live in, and you can find providers in your area that have special testing to look beyond just the traditional labs and labs that are covered by insurance, but looking at a full thyroid panel, looking at an iron panel, looking to see what else might be going, looking at your sex hormones, your blood counts, your chemistry panels, really diving into what's going on, probably doing some potential stool testing, food sensitivity testing, etc., but I would not settle for someone telling you that everything is normal if you feel that poorly. And to me, it's almost the analogy of peeling an onion. There're probably multiple layers of things that could potentially be contributing to one another, but you need an absolutely thorough diagnostic evaluation. Again, IFM, no affiliation with them, but that's generally where I send people that live in parts of the country, where perhaps I don't know have a personal recommendation in their area, but there's absolutely a provider that can help you.

Melanie Avalon: Awesome. Yeah, I think that's an amazing resource and I really empathize with you, Sandra, because it's so common and it's so confusing, and I've been there and often have existed there, which is just not knowing and not being able to find somebody who can help you and just not knowing what the source is. And I remember for me, especially when I was at the really-- And I'd be curious of your thoughts on this, Cynthia. When I was at my really low point with my energy levels and everything I was experiencing and before I knew exactly what was going on, I remember on the one hand thinking like, "I should be able to just intuitively figure this out." If I just listen to my body, I should be able to eat the foods that nourish me, and I should be able to sleep, and I should be able to rest, and I should be able to get better. 

But looking back, I actually don't-- I don't know that I could have intuitively lived my way out of my situation, because for me it ended up being severe anemia to the point of hospitalization and ended up being mercury toxicity, thyroid issues all along the way and I guess, I just say that to say the importance of finding a practitioner who will test and find the things that are happening. Does that question make sense? I've been haunted by this question for so long, like, feeling like you should be able to just intuitively get better versus needing to test and work with somebody.

Cynthia Thurlow: I'm probably not the best person to ask that up, because I come from a clinical background and to me, as she's describing what's happening, I'm thinking a really thorough medical history is important and then you need testing to backup what you're already thinking. And so, I think for anyone that's listening, even people like myself with as much knowledge as I've had, I definitely have had periods where I've had to humbly surrender and let a practitioner figure it out for me. Intuitive to a point, but then I think we also get to a point where we start second guessing ourselves. I'll give you a good example. 

I've had hypothyroidism for about six years and was doing pretty well till about two years ago when my Nature Throid was taken off the market and many people that are probably listening, they probably have been on a series of different medications. And now, I truly believe I'm working with probably one of the smartest physicians I've ever met in my entire life. And I don't just say that, because I know him personally as well as professionally. And I'm on compounded medication now and he is checking my thyroid levels every two weeks and he has told me, he said, "You have one of the most interesting thyroid panel results I've ever seen." And I was like, "I don't necessarily want to have the most interesting thyroid panel you've ever seen." But I do feel sometimes. we have to wait to work with the people that are going to be able to get us to the next level. 

And so, part of why I'm saying this in the context of answering Sandra's question is really understanding that the right practitioner is out there and it sounds like she's taking account of all the things she's experiencing and now, just needs the right practitioner to help her figure it all out. Really looking at that relationship as a partnership, so that they can work together, because how many people listening irrespective of what age they are are being told exactly these things, you have all these constellation of symptoms, you feel terrible, and you're being told everything's normal. And it's not normal, right? And so, part of this is empowerment and part of this is getting connected to the right people. 

Melanie Avalon: I'm so glad you mentioned that about your experience with the hypothyroidism, especially-- I know I've mentioned my journey and especially the doctor I'm working with now that I started working with because I actually found her under my insurance. Upfront, she actually tested all the things like TSH, free T3, reverse T3, everything and she seemed to really understand. But as we progress, the decisions she's making based on my thyroid medication, they don't make sense. They don't make sense and she also like you're mentioning your practitioner tests every two weeks. She's like, "Well, we'll test in three, or four, or five months." I don't know, after changing your dose if we should wait that long. All that to say, what Cynthia said at the very beginning answering Sandra's question, which I'm not being a good example of right now but the importance of finding somebody who really understands you can work with you. 

I do want to provide a resource actually that might be helpful for Sandra and other listeners. I just interviewed last week. I brought back Doc-Koz. His first book was called Unfunc Your Gut and people loved it. And he has a new book called Get the Func Out. Func is spelled F-U-N-C. It's like a play on functional medicine. That book is very comprehensive and covers basically the seven hormones that he thinks are related to health like fatigue and issue, thyroid related hormones, progesterone, testosterone, cortisol, all these things. It's very, very helpful and eye opening and he actually lists all of the tests that he likes specifically and I think it's just a valuable resource. Or, if you do find a practitioner to work with, especially if it is a conventional doctor under your insurance, it's empowering because you can actually have a list of things that your doctor might be opening to test. So, I'll put a link in the show notes. Actually, by the time this airs, because that book is coming out pretty soon, yeah because this episode comes out the 17th. It will be coming out next week. So, I'll put links to that in the show notes. Okay, shall we go on to our next question?

Cynthia Thurlow: Absolutely. This is from Tracy. Subject is: "Gum." "Hi, ladies. I'm thankful for your guys' podcasts and I think I've converted at least a dozen people since I started back in October. One being my husband, who has blown me out of the water with opening his window on 5 PM or 6 PM and closing it four to five hours later. He looks great and has lost all his pregnancy sympathy weight. He calls it ha-ha and then my mom who is down 30 to 40 pounds in the last four to five months or so with an average 12 to six-window. I am a hairstylist and I'm constantly in people's faces. I start work around 1 PM or 2 PM a couple days a week and much earlier on Saturdays. 

I prefer to chew gum throughout the day to make sure I'm not breathing bad breath at my clients. I brush my teeth often, but I just can't handle the thought of not having a piece of gum in my mouth while I'm talking away. I've tried the WOW Drops and peppermint essential oil, but it is just not the same in at times I'm working without any breaks for hours at a time. Would it be beneficial at all if I chewed gum a couple of hours before opening my window while working or would it just be the same as having cream in my coffee at the same time? I love to advocate the clean fast. I have kept 20 pounds off back to pre-baby weight thanks to intermittent fasting and working out three to four days a week as of having a baby in late June, but would like to continue to keep losing maybe another 10 to 15 pounds. I've been staying around the same size for a few months now. I know I lose weight when I can fast for longer periods of time consistently, but I'm struggling with workday fasting. I used to start work later in the day. So, this was not an issue. 

I find myself opening my window with food earlier on work days and leaving it open way past the eight hours, just so I can chew gum and eat after my day is over with my husband. I could care less about chewing gum when I'm not at work and closing my window early in the evening just doesn't work for me. My perfect scenario would be a 19:5 opening my window on 3 PM or 4 PM. Thank you and sorry, if this is a no brainer. I just wanted to know you guys’ thoughts and if you had other ideas on how to work around this."

Melanie Avalon: Awesome. Well, thank you, Tracy for your question. I'm just reading it. Cynthia, are you reading this as the gum is triggering her hunger, making her want to open her window earlier to eat? Is that how you're reading this?

Cynthia Thurlow: I think I can read it from two angles that or that she wants to chew gum because the purpose of the gum is to keep her breath smelling fresh for her customers and her clients and we could unpack that a couple different ways.

Melanie Avalon: Yeah, because she says, I find myself opening my window with food earlier on workdays and leaving it open way past the eight hours, just so I can chew gum and eat after my day is over. I'm not understanding is, is she opening the window with food, so she can chew the gum or is she chewing the gum which makes her hungry, which makes her open the window with food?

Cynthia Thurlow: I think it's more the latter. That's my assumption.

Melanie Avalon: Okay. In any case, I guess, regardless of the details, the gum situation is making her open her window earlier for whatever reason. So, Tracy, I as well have a slight borderline obsession with clean breath. And there's a reason because of this. I think I've shared this story on the podcast before. I don't know, I think I have. No, it was right after graduating, I went on a date with a man and I had gone through like a garlic phase. I just discovered garlic and I didn't realize how intense garlic was. And this was a first date with this guy and it was blind. I think he hit on me in Costco and asked me out. I don't know, but we had mutual friends. I went out on one date and then at the end, he tried to kiss me and I don't, in case boys are wondering, I'm not going to kiss you on the first date. So, I refused that kiss and then he made a comment about how I had had garlic earlier and then he said, but I should be flattered that he still wanted to kiss me even though of the garlic. 

In any case, that was a little bit traumatic for me and ever since then I have been uber obsessed with fresh breath. It's a problem. And it's the reason that I started using that peppermint oil spray that she talks about which we've started a fandom with on the show. We'll put links to it in the show notes. And it's on ifpodcast/stuffwelike. And I realized Tracy said, it doesn't really work for her, but it's a game changer for me. I basically just put a few drops of organic food grade peppermint essential oil, and water in these adorable little glass bottles that they have on Amazon and I keep those in my purse. Those really work for me. They're way more potent than chewing gum and they just clear out my whole head. 

All of that to say, Tracy, I know, you think gum is the only answer to the bad breath situation. But I would challenge you that gum is not the only answer. There are other answers here. One, it has actually nothing to do with the actual freshening of the breath. What you're eating and the timing of it and how you're digesting can have a huge effect on your breath. And also, obviously, the garlic is an example of something that stays with you, but there are things that you eat that because of those sulfur compounds and things like that will have a lasting effect on your breath the next day. I personally know that based on what I'm eating, it can affect how my breath smells. 

Something that might be really, really helpful. I recently aired an episode with a company called Bristle. They are incredible. They test your oral microbiome, which nobody is testing the oral microbiome. I’m becoming obsessed with this company, because I had thought for a long time that the oral microbiome was a big deal and nobody was talking about it and I'm pretty-- The more I learn about it through Bristle, the more I'm realizing that was the case. I aired an episode with Danny Grannick, who is one of the founders. I'll put a link to that in the show notes. It is the most eye-opening conversation ever about the oral microbiome. 

If you do Bristle, they'll test your oral microbiome and then it's all science based and they make personalized recommendations based on your gut bacteria. You basically get a list of results and it will show how your personal gut bacteria correlates to things like cavities, and gum disease, and halitosis, which is bad breath and then it provides personalized recommendations, not for products made by them, just ingredients that can address that. I would get that and I would follow the recommendations for the halitosis, because there might be some products that can work for you and I know the products, I know there can be a lot of debate about the toxicity of mouthwashes and things like that, but I think it's a very complicated situation and I think especially if you listen to my episode with Danny, you'll realize how there are multiple approaches to this, like, food, diet also products may work. 

I know, for example, I actually really like TheraBreath, the one that is unflavored and doesn't have any sweeteners or anything in it but it has an ingredient in it that specifically-- this is such a casual way of describing it. It deactivates the sulfur-producing bacteria, I think. I'm probably not correctly communicating what it does. But in any case, it has a lasting effect that really for me lasts all day. So, that might be something to try. All of that said, I will get Bristle-- Oh, if you'd like a discount, you can go to melanieavalon.com/bristle, B-R-I-S-T-L-E and the coupon code, MELANIEAVALON will get you a discount. I had to ask them for this. It will actually get you a discount on their subscriptions as well, which those are already discounted. So, that's actually a really good route to go, especially if you think you're going to be retesting. 

I would do that. I would reconsider that maybe you don't have to be chewing gum. I know you said you don't like the peppermint spray. Maybe if you just reevaluate and try it again. I know she said she doesn't like it. I just think there are other options than chewing gum. As far as if the gum actually breaks the fast, there're a lot of ingredients and different gums, a lot of them can be sweet and just the chewing process, I don't know that our brains know that when we're chewing gum, that it's not food. It's a very food stimulating process. It's definitely sending mixed signals to our body. I'm not a fan of chewing gum during the fast. And you're experiencing the effects of that. You're saying, it makes you more hungry. So, I would just reframe, if maybe that you can try some other options. Oh, I also really like oil pulling every morning. Cynthia, that was long.

Cynthia Thurlow: Yeah. No, that was a very comprehensive response. I would just echo that. I understand that desire to have clean breath. I am not a coffee drinker and so, when I used to round on patients in the hospital, I would actually chew gum, but discreetly chew gum. No one knew I was chewing gum, because one of my biggest pet peeves are when people chew gum in a noticeable way, which I know is not the question. But I always tuck gum up into my gum. And so, I would chew it in between seeing patients. And during the pandemic, I stopped chewing gum, because obviously, I was home and there was no need to do it. And I realized, I actually didn't enjoy chewing gum. I just felt this compulsion. It became a compulsion when I was in the car or when I was seeing patients and so, what that has demonstrated for me and why I think this is relevant to Tracy is that what I really need to do is be hydrating more, because when your mouth is hydrated with water, that breath concern is not a concern, because sometimes dehydration will mitigate the feeling of having poor smelling breath and the other thing is, a lot of people drink copious amounts of coffee and so that can give them that kind of stale appearance. 

But the other thing that I would loop into what Melanie said is, Trina Felber is an advanced practice nurse and she has a company called Primal Life Organics. I've learned a lot about mouth care and the mouth microbiome. And so, I do tongue scraping every morning, I use her clean dental products, which don't disrupt the mouth microbiome and we'll link up that podcast I did with her, as well as a discount to Primal Life Organics. But I really do think looking closely at what you're eating, what you're drinking, and then also oral microbiome care can be hugely impactful. And I think for a lot of people, it's really just a habit. I do think that when you're chewing gum, your body thinks you're going to be eating food that you're actually going to swallow food. And so, do you get a cephalic phase insulin response potentially. Most of the gums that last a long time in terms of flavor have artificial flavors in them. They've got sucralose, they've got a lot of chunky things. Let's be clear, the gums that are clean don't last very long and that's from personal experience I can tell you. You definitely want to try to mitigate the net impact of some of those foods as much as you can. Then does it mean that you'll go from chewing gum all day long to not chewing gum? Probably not, but maybe integrating some of these other thoughts and I do like Melanie’s suggestion to rethink whether it's you're chewing on a fennel seed, or you're trying the WOW Drops, or using some essential oils, or you're drinking more water, those actually have some health benefits versus gum unfortunately has a lot of things about it that probably are not ideal to be doing all the time and it sounds like it's actually making you hungrier, which makes sense that your body thinks food is coming. 

The other thing that I just have to loop in here is that you're obviously a young woman still probably at peak childbearing age. Fasting for your menstrual cycle is really important. You may find that you struggle more on days when you're closer to getting your period and you really want to know that there are times in your cycle where it's ideally optimized to fast from the day you start bleeding up until ovulation. And then as you're getting closer to your menstrual cycle, the last five to seven days, you may want to back off on the fasting a little bit. And certainly, it sounds you've got a very tight window, a very narrow window. And the last piece that all add in here is, just making sure you're eating enough food. You were saying you're still trying to lose more weight and your body may think that you're not eating food, if you're not able to get two good-sized meals into a pretty tight window. So, those are my thoughts. I hope that's helpful.

Melanie Avalon: That was so helpful. You exactly articulated what I was trying to articulate, but you're much better, because you had the personal experience, which was, like, you're talking about how you really thought you needed it and then you realized it was a habit. It wasn't really about the gun per se, because it's interesting. Tracy was saying that the WOW Drops and the peppermint essential oil aren't the same. If the goal is addressing the clean breath, drops and the peppermint essential oil, they're going to have a very similar effect. So, it not being the same as probably that habitual aspect of wanting to chew the gum like Cynthia was experiencing. That was very powerful. Also, I forgot, do you do tongue scraping, Cynthia?

Cynthia Thurlow: I do. I do every day. Actually, it's become part of my morning ritual that my husband thinks is really funny and I'm like, "Oh, but look at all the stuff you pull off your tongue." [laughs] 

Melanie Avalon: It's game changer for me. 

Cynthia Thurlow: Mm-hmm. That's great for breath and everything else. I remember feeling paranoid when I was rounding. If I didn't have a mint or gum, it was because I had been conditioned. I probably walked around dehydrated all day long, because I didn't want to have to pee, God forbid. If you're dehydrated, you can get funky breath just from that. In many ways, I think the freedom of not chewing gum anymore is that I don't feel that way. It's like, "Oh, I'm feeling my breath is getting funky. I'm going to go drink some water." And then inevitably, I feel between that and tongue scraping and changing my dental products has really made a big impact in a positive way.

Melanie Avalon: Awesome. Definitely, report back Tracy, if you find something that works for you implementing all of this. So, awesome. 

Hi, friends. So, you guys know how seriously I take my health routine. That is probably the understatement of the year. One of my literal non-negotiables that I talk about all the time that I use every single day of my life is getting my daily dose of red light therapy. For years now, yes, years I've been using Joovv and I love it because it is so relaxing and so easy to use. You've probably heard me talk about Joovv before. That's J-O-O-V-V. I use my devices daily to support healthy cellular function, which is the literal foundation of our health. If you've heard any of my episodes on mitochondrial health, you know this is true. Having healthy cellular function helps give me peace of mind that my body is working efficiently and has the energy that it needs to get through the day. There are so many clinically proven benefits from red light therapy and I have personally experienced so many of them. I use the red light to naturally regulate my circadian rhythm. I wind down with it at night and wake up in the morning with it. Whenever I have any muscle pain or soreness, I shine my Joovv red light on it and the pain instantly goes away. It's actually shocking. I love it for skin health. It makes my skin glow. 

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Melanie Avalon: Shall we answer one more question? 

Cynthia Thurlow: Absolutely. This comes from Anna. The subject is: "fasting, electrolytes, and hot humid weather." Anna says, "Hi, ladies, I love the podcast. Definitely wouldn't have got through the first few months of one meal a day, 23:1 to 20:4 without it as it took me two months to become fat adapted. I've been doing one meal a day for two to three months and now that I'm fat adapted, it's become so easy and the scale hasn't moved much. I thought I'd try a 48-hour fast. I have the weight to lose 25 plus kilograms. I work outdoors in the hot, humid tropics, very sweaty. I drink around 7 to 10 liters of water a day around 2 gallons. I also clean fast. 48-hour fast was going so well. I was feeling completely fine and happy at work until around hour 43, I suddenly got blurry spots in my vision, felt extremely lightheaded, and really couldn't focus. I could hardly see or think. I'm wondering if this is just because I didn't supplement with electrolytes. I honestly thought a two-day fast should be fine and it felt so good until the eye floaters popped up. I felt normal the next day again after eating and sleeping. I am a healthy besides being overweight ha-ha young woman. I just wanted to write in because I think a lot of the info you guys give out is more suitable for indoor workers and more temperate climates than where I live. Thank you both so much for all your hard work on this podcast."

Cynthia Thurlow: Well, thank you, Anna for your question. I would say, first and foremost, there's a couple things that come to mind. I think if you're working in an outdoor environment where it's very hot and humid, you're doing a lot of sweating and you're not using electrolytes you're setting yourself up to become dehydrated very easily. I love that you clean fast. I think that's very important but electrolytes and fasting go together. It's not an either/or. In fact, I teach women all the time that you salt your food, use electrolytes and no it's not a couple sprinkles of salt in your water. You need a comprehensive product. And so, understanding the role of magnesium, and potassium, and chloride, and sodium is very, very important. We know that when you're in a fasted state, you're also going to upregulate excretion of sodium in your urine. Even though, you're consuming 2 gallons of water a day, you're not going to hold on to it. So, you will get dehydrated. 

You mentioned what sounds to me, you became symptomatic during a longer fast which I also wouldn't recommend, if you're in an outside environment and you're going a long period of time. A couple things for anyone who's fasting, especially if you're in a hot, humid environment, you're outside, water with electrolytes together throughout the day. There are plenty of clean products on the market. I think about unflavored LMNT, I think about Redmond's, I also have a product called Simply Hydration, that's also safe to take, it will not break a clean fast. And then if you're comfortable consuming stevia sweetened product, LMNT also makes a wonderful product with lots of flavors. My favorite is orange, obsessed with it. In my house, grapefruit is also a very popular option as well but I think if you're setting yourself up for longer fasts and you're not using electrolytes, that's a great concern. 

The other thing is, you're mentioning that you're in a position where you still want to lose more weight and I think that you probably need to have some varying amounts of time in which you're eating. You have a very compressed feeding window, you're not going to be able to get enough protein in a very compressed feeding window. I would recommend at least two meals in a feeding window. If you really like OMAD and that's your preference, then I would ensure that you are not over fasting because your body may be holding on to everything in an effort to-- because it perceives that you're not bringing on enough food in an unfed state. So, just some things to consider but I would say electrolytes are going to be your friend, you want to embrace them, find a product you like. 

And then the other thing is, I know Mel and I’ve both on several podcasts with Robb Wolf. We'll be happy to link up our podcasts with him but he provides some really compelling research and information that makes electrolyte utilization really important with fasting. And then lastly, I don't know how old you are but you want to make sure that you're not over fasting in a timeframe around when you'll get your menstrual cycle, because that can also make it quite challenging to fast effectively.

Melanie Avalon: That was so comprehensive and so helpful. 

Cynthia Thurlow: Thank you.

Melanie Avalon: Appropriately enough. LMNT is a sponsor on today's episode. You can actually go and listen to wherever we run that ad in this show. So, if you go to drinklmnt.com/ifpodcast, that's D-R-I-N-K-L-M-N-T dot com slash ifpodcast I believe the offer right now is eight single serving packets for free with any order. So, like Cynthia mentioned, the unflavored one is just epic and wonderful to be clean fast friendly and then depending on the context, they do have a lot of really amazing flavors. And word on the street. Have you made--? Oh, wait, you don't really drink. I know a lot of people make a margarita with the citrus salt one. Yeah, so, I think everything that Cynthia said, I echo. Those are really great suggestions. 

I did want to clarify because she was saying that the info that we give may be more suitable for indoor workers in more temperate climates. In general, the longer fasts, I think for anybody they shouldn't just be done casually. I think indoor or outdoor, there's definitely be attention paid to doing it correctly and paying attention to electrolytes. And definitely thank you, Anna, for drawing attention to that. Definitely, if you are in a situation like her, where you're in the elements and it's hot, and dehydration possibly being a factor, needing more water that definitely people should not take that lightly. I know we actually have had questions in the past about that and it definitely can make a big difference and not even just with longer fasts, but with shorter fasts as well. So, yeah, I'd be curious, Anna, if you try it again with electrolytes, let us know how it goes.

Cynthia Thurlow: Yeah, I think it goes without saying, I see a lot of people, men and women that fast and then wonder why they're dizzy, or they've got cramping, or they're new to fasting entirely, and they get "keto flu," and just explain the physiology of the body and how when we are eating a lower carbohydrate diet, and we get these renal losses of sodium, how that can mitigate and precipitate some of the side effects people will experience. And so, I'm not a believer in white knuckling it through fasting and certainly, electrolytes to me go together so beautifully with fasting. You just have to find a product that you like. For me, it's orange salt all the way during my feeding window and then my other product that I have that is not too salty. That's one of the things. Sometimes, people will say, the unflavored varieties are too salty. I totally get it. You just need to dilute it with more water and it'll be totally fine.

Melanie Avalon: Well, I'm so glad you said that, because yes, some people love it as is, but you really can dilute it and make it last longer. I've given one of my friends a lot of boxes of LMNT, and she loves it, and she just drinks them like candy. Some people just like it as is. Okay, awesome. Well, this has been absolutely wonderful. So, a few things for listeners before we go. If you would like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can follow us on Instagram. We are @ifpodcast, I am @melanieavalon, Cynthia is @cynthia_thurlow_. And the show notes for today's episode that will have a full transcript, as well as links to everything that we talked about will be at ifpodcast.com/episode287. All right, well, this was fun, Cynthia. I feel we haven't talked a lot recently, because it's been so crazy. So, it's been really nice to record today.

Cynthia Thurlow: Absolutely. And it just means for listeners, we're going to dive right in on our next recording. So, we'll get more questions fit into our discussion.

Melanie Avalon: Yeah. So, all right. Well, I will talk to you very soon. But for listeners, we will see you guys all next week. 

Cynthia Thurlow: Sounds good. 

Melanie Avalon: Bye. 

Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team. Administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week.

[Transcription provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Oct 09

Episode 286: Thyroid Regulation, Iodine, Fasting For Your Cycle, Insulin, Glucagon, High Protein Diets, Surgical Menopause, Prescription Medication, And More!

Intermittent Fasting

Welcome to Episode 286 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

BUTCHERBOX: Grass-Fed Beef, Organic Chicken, Heritage Pork, Wild-Caught Seafood: Nutrient-Rich, Raised Sustainably The Way Nature Intended, And Shipped Straight To Your Door! For A Limited Time Go To Butcherbox.com/ifpodcast And Get A 10 oz New York strip steaks and 8 oz of lobster claw and knuckle meat FREE in your first order!

BEAUTY AND THE BROTH: Support Your Health With Delicious USDA Organic Beauty & The Broth Bone Broth! It's Shelf Stable With No Preservatives, And No Salt Added. Choose Grass Fed, Grass Finished Beef, Or Free Range, Antibiotic And Hormone-Free Chicken, or Their NEW Organic Vegan Mushroom Broth Concentrate! The Concentrated Packets Are 8x Stronger Than Any Cup Of Broth: Simply Reconstitute With 8 Ounces Of Hot Water. They’re Convenient To Take Anywhere On The Go, Especially Travel! Go To melanieavalon.com/broth To Get 15% Off Any Order With The Code MelanieAvalon!

To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get A 10 Oz New York Strip Steaks And 8 Oz Of Lobster Claw And Knuckle Meat FREE In Your First Order!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

The Melanie Avalon Biohacking Podcast Episode #12 - Elle Russ

Ep. 129 – Middle Age, Menopause, and Mindset: How These Components Affect Your Thyroid Health with Elle Russ

Ep. 105 Thyroid Physiology and Chronic Illness – with Dr. Eric Balcavage

Ep. 166 How to Maintain a Healthier Thyroid: Interesting Thyroid Physiology Health & Preventative Care with Dr. Eric Balcavage

The Melanie Avalon Biohacking Podcast Episode #1 - Dr. Alan Christianson

Ep. 154 How to Normalize Your Thyroid Function: What You Can Do To Help Support Your Body with Dr. Alan Christianson

Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist, And Use The Code Melanieavalon For 10% On Any Order At Avalonx.Us And MDlogichealth.Com!

Text "AVALONX" To 877-861-8318 For A One Time 20% Off Code for avalonx.us

BEAUTY AND THE BROTH: Go To melanieavalon.com/broth To Get 15% Off Any Order With The Code MelanieAvalon!

Listener Q&A: Ashley - Struggling with consistency

Listener Q&A: Monica - 3rd time is a charm?

High dietary protein intake, reducing or eliciting insulin resistance?

Effects of high-protein diet on glycemic control, insulin resistance and blood pressure in type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

Protein: metabolism and effect on blood glucose levels

Ep. 109 How To Transform Your Health With Diet And Exercise – With Dr. Ted Naiman

The Melanie Avalon Podcast Episode # 30 William Shewfelt And Ted Naiman

The Melanie Avalon Biohacking Podcast Episode #94 - Marty Kendall

Listener Q&A: Jessica - Menopause, HRT, etc

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 286 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this podcast do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for the Intermittent Fasting Podcast.

Hi friends, I'm about to tell you how to get two grass-fed, grass-finished 10-ounce New York strips and one-half pound of sustainable wild-caught lobster meat all for free? Yes, for free. We are huge fans around here of a company called ButcherBox. They deliver 100% grass-fed, grass-finished beef, free-range organic chicken, heritage-breed pork, that's really hard to find, by the way, and wild-caught sustainable and responsible seafood shipped directly to your door. When you become a member, you're joining a community focused on doing what's better for everyone. That includes caring about the lives of animals, the livelihoods of farmers, treating our planet with respect and enjoying deliciously better meals together.

There is a lot of confusion out there when it comes to transparency regarding raising practices, what is actually in our food, how animals are being treated. I did so much research on ButcherBox, you can actually check out my blog post all about it at melanieavalon.com/butcherbox. But I am so grateful for all of the information that I learned about their company. All of their beef is 100% grass fed and grass finished. That's really hard to find. They work personally with all the farmers to truly support the regenerative agriculture system. I also did an interview with Robb Wolf on my show, The Melanie Avalon Biohacking Podcast, all about the massive importance of supporting regenerative agriculture for the sustainability of not only ourselves but the planet. This is so important to me. I'll put a link to that in the show notes.

The value is incredible, the average cost is actually less than $6 per meal. And it's so easy. Everything ships directly to your door. I am a huge steak lover. Every time I go to a restaurant, I usually order the steak. Oh, my goodness, the ButcherBox steaks are amazing. And we are so excited because ButcherBox has an incredible offer just for our audience. You can get some of those steaks for free and lobster to go with it. You can go to butcherbox.com/ifpodcast and get two 10-ounce, grass-fed, grass-finished, New York strips and one-half pound of wild caught sustainably raised lobster meat all for free in your first box. Yes, completely free. That's butcherbox.com/ifpodcast and we'll put all this information in the show notes.

And one more thing before we jump in. Are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense, because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting. It's actually our skincare and makeup.

As it turns out, Europe has banned over eight thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disruptors, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup maybe playing a role in that.

Beyond weight gain and weight loss, these compounds have very detrimental effects on our health, and they affect the health of our future generations. That's because ladies, when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years. Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means, when you put on some conventional lipstick, 30 years later, maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves.

That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so, you can truly feel good about what you put on. And friends, these products really, really work. They are incredible, they have Countertime for anti-aging, Countermatch for normal skin, Countercontrol for acne and oily prone, and Counterstart for sensitive. I use their overnight resurfacing peel and vitamin C serum every single night of my life. And their makeup is amazing. Check on my Instagram to see what it looks like. Tina Fey even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more.

You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20, to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out. You can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you're thinking of making Clean Beauty and Safe Skincare, a part of your future, like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like the Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20, to get 20% off your first order. And we'll put all this information in the show notes. All right, now, back to the show.

Hi everybody and welcome, this is episode number 286, of The Intermittent Fasting Podcast. I'm Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, Melanie, how are you?

Melanie Avalon: Good, how about you?

Cynthia Thurlow: We were just commiserating about this. But when your thyroid medication gets changed, it can sometimes be a little bit of a bumpy ride. So, I'm feeling I need to prop up my eyes with toothpicks today.

Melanie Avalon: I've been on the same bus that you've been on with trying all different forms of thyroid medication. It's just so complicated because there's so many opinions and there's so many options. And it can be hard to really find what works for you.

Cynthia Thurlow: Totally, I think if anyone that has an underactive thyroid that's listening, I know you understand [chuckles]. I know you understand, so I'm trying to just wait it out. My functional medicine doc is encouraging me to wait it out another week and get my labs checked. Goodness, I feel I need a power injection in the afternoon because I feel like I need a nap. And who has time for that every day?

Melanie Avalon: Well, I will say, this actually made me think about this. Sort of recently, I was in a period where I was feeling I needed a nap every day. And I just realized you know how you don't really notice when the negative things are gone? I just feel when I'm experiencing something negative once it actually goes away, I don't you may normally realize it. I just realized, "Oh, I haven't been needing a nap every day." I think the difference is, when I got sick a few weeks ago and started really high dosing the NMN and I stayed on the NMN every day at a higher dose. I don't need naps anymore. I think that's what it is, I don't know what else it would be. Although I have realized I feel a little bit more wired at night as well. So, I'm maybe I'm too high dosing. So, that's a benefit. I didn't used to be a nap person, and then I was and I'm not. How about you?

Cynthia Thurlow: Every once in a while, might need it but I generally, power through my day. And on a lot of levels, the fact that I consistently every single day, I'm this tired, the only variable that's changed is the thyroid medicine. And I knew this would happen because what typically happens is I get insomnia. And then, I have a crash in the afternoon. That has been a consistent pattern. Even though they've increased my T4, they lowered my T3. And my functional medicine doc said, and I quote, "You have the most interesting thyroid panel I've ever seen." And I said I don't want to be interesting I just want to be normal. I'm trusting the process. And he's absolutely brilliant and one of the smartest physicians I've ever met, so I am trusting in the process but in between, I will need naps in order to function.

Melanie Avalon: Do you think you'll increase your T3?

Cynthia Thurlow: He might. I think it's interesting, I'm supposed to have lab, he wanted labs drawn two weeks after I started the medication. So, I've already got that appointment set up, and I knew as soon as I started, I knew that there would be this bumpy-- this has been the pattern every single time they've changed my medications. In fact, I thought for a moment, because I keep all my old medicines just to describe to people, I'm not kidding, I really have been on 10 different prescriptions in the past two years. And it's a bag of thyroid medicine. And my husband was like, "What is that?" And I was like, "I don't know, it's a trophy. I'm keeping this for posterity's sake, I'm not sure." But to really demonstrate this is what people go through. And I'm a clinician and we still haven't gotten it right, so it goes on to just suggest that many people listening, are probably struggling with the same thing. So, that's why I wanted to share, to be transparent and say, "Yes, I'm a clinician. But yes, I'm still struggling to get the right combination of medications."

Melanie Avalon: I don't love that you're experiencing that. But [chuckles] I love it that's your approach. And yeah, some good resources for listeners. Have you interviewed Elle Russ?

Cynthia Thurlow: I have Elle and Eric Balcavage, Balcavage, sorry, I just mangled his last name, he's wonderful. He does a great Thyroid Thursday on Instagram. So does a lot of teaching. I think he's a great resource. And we both have had Alan Christenson on, but I would say Eric does a lot of didactic teaching as a clinician, which I love. And then Elle is all about empowerment, which is fantastic.

Melanie Avalon: Yeah. And Dr. Alan Christianson, who you just mentioned, it's funny, when I first met him, I was really struggling with my own thyroid panels. He is the nicest person ever because I literally just met him, and we've been vaguely emailing actually about intermittent fasting stuff. We were debating the literature on it. I guess at some point, my own thyroid issues came up and he was so nice. At one point, he was like, "Well, send me your labs to look at." I sent them to him, and he called me, he was like, "I have to talk to you about this [laughs] We have to get this fixed now." I was like, "Oh my goodness. You're the nicest person ever." He has a book called The Thyroid Reset Diet. He was actually my first episode of the The Melanie Avalon Biohacking Podcast.

Cynthia Thurlow: You what's funny, so fast facts. Alan was part of my Mastermind. When I joined it, and I recall the very first time I met him in person, I was sitting next to him at a lunch, and I was trying to be really cool. Because sometimes when you meet these people that you've been following them for years, and then you're socially around them. All I say to myself is, "Just be cool. He is a normal guy." And he is as nice as nice could be. I just think Midwesterners in general are just such nice, down to earth, human beings. And he really is as nice as he appears to be, and very quiet and introverted and I really enjoyed the time that I had with him, but I think he's a great resource.

Another funny thing to share with you is that the podcast team that I had at the time that I recorded a podcast with him about his new book about iodine, the podcast title was Intermittent Fasting and Thyroid Health, and I just about had a minor heart attack, because he's not a big fan of Intermittent Fasting. And I literally was like, "You cannot put that out. You cannot do that." And then, I had to explain the context. I was like, that is absolutely the worst title you could ever come up with.

Melanie Avalon: It's funny, the way I met him actually was-- I don't know if it was him or it was probably his publisher, or publicist, or somebody. They pitched him to come on this show. And it was for his metabolic reset diet. And literally at that time, he literally had a video on YouTube about-- it was basically deconstructing intermittent fasting. I wanted to engage with them. But Gin was not too excited about the idea. And so, that's why I started talking to him via email and started discussing the studies. And he actually took down that video, I think, after it because we talked about it some more and I think he realized there was a slightly more nuanced perspective on that specific content that he had created. And I just thought that was so impressive. But yeah, I know, I love his work. He has the thyroid reset diet, the adrenal reset diet. What's the book on iodine called?

Cynthia Thurlow: No.

Melanie Avalon: That's the thyroid reset diet.

Cynthia Thurlow: Yes.

Melanie Avalon: I'm still haunted by that. I still don't know what I think about it.

Cynthia Thurlow: I don't agree, politely I don't agree.

Melanie Avalon: I need to reread it, because it's interesting, because it's so contrary. It's not like it's slightly different than the popular idea. So basically, for listeners, a lot of people in the functional health world, and I guess nonfunctional as well, advocate needing more iodine to help thyroid and just health in general. And a majority of the book is about how iodine is actually the issue, and we actually need to be on a low-iodine diet. So, yeah, I don't know.

Cynthia Thurlow: I think it's important to entertain the possibility that there may be aspects to that argument that are applicable, but I don't necessarily agree but I don't have enough background, I'm not an iodine specialist, but I do ask my functional medicine friends and I would say iodine is a controversial issue because you have people like Brownstein, who is pro iodine, and wrote the book, The Iodine Crisis. And then, you have other doctors that feel differently. So, we have to agree to disagree. And I don't feel I know enough to feel I could take a stand on it. I'm in a state of flux.

Melanie Avalon: Reading his book, it's very convincing. And I do think there's probably a lot to maybe the difference between people who are eating a conventional diet, so they're getting iodized salt, compared to people who might not be having conventional salt, and so not having that source, I do wonder what role that plays. I do know iodine-- I know I've shared this on the show before I don't know if I've told you before. It's the only supplement that I experimented with that I had such obvious scary reaction that I was like, "I'm never taken this ever again." My eyes literally turned bloodshot red.

Cynthia Thurlow: Really?

Melanie Avalon: Yeah, that's kind of frightening [chuckles]. I remember I can't-- I can't even know if I can go to work. It was when I was still waiting tables. Yeah, so we will put links in the show notes. To the interviews we have had with all of these individuals.

One little announcement I do want to share with listeners, by the time this comes out, I feel bad because I think that this special will have already ended but the concept is still available, which is all the more reason you need to be on my email list for my AvalonX Supplements, which is avalonx.us/emaillist. And also, you can actually get text updates, and a 20% off one time code. I'm so excited, I set up text updates. If you text 'AvalonX' to 877-861-8318-- I'm just going to emphasize for clarity, Cynthia, have you ever set up a text service?

I have not. It's really funny because I say text 'AvalonX', all of the iterations I get of people texting that it's not AvalonX, people will text Avalons, or, give me the code or all these things. I'm like, "No, you have to text just the word AvalonX." So, it's a kind of like-- I don't know, it's just really funny to see all the messages. So, that's A-V-A-L-O-N-X to 877-861-8318. And if you are on that list, you would have known that we launched magnesium subscriptions. And we actually had a two-week window where you could get grandfathered in for life at a 25% discount, which is the largest discount we should technically probably ever do. And you get it for life as long as you stay on the subscription, which you can also pause. So, that's amazing, if you didn't snag the 25% you can still get a subscription now at 15%, so that's an option. Anything else from you, Cynthia?

Cynthia Thurlow: I am hopeful that we will finalize a package for the creatine so that I can get a date that this will be available. That is, I've got my fingers crossed.

Melanie Avalon: I'm very excited for you. Then someday, you'll have subscriptions on that as well, probably?

Cynthia Thurlow: Yes, you'll be able to tell me all about text options too.

Melanie Avalon: That's the thing I've learned, is be very clear in what people text to you.

Cynthia Thurlow: Keep it simple.

Melanie Avalon: It is simple, but people just extrapolate and text all the things and I'm like, "No, that is not what it says."

Cynthia Thurlow: It says not direct access to Melanie 24/7.

Melanie Avalon: Is not what it says.

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Shall we jump into everything for today?

Cynthia Thurlow: Absolutely.

Melanie Avalon: To start things off, we have a question from Ashley and the subject is "Struggling with consistency." And Ashley says, "Hi, I have been a fan and I've listened to your podcast from the start, which means I started IF back in April of 2017. I wish I could say I have done IF every single day since then. But no, it has been the struggle bus for me to do it consistently." Typically, since 2017, I IF on average four to five days a week. Some weeks are better than others when I can complete six to seven days of IF, where other weeks are harder one to two days. My window varies from 16 hours to 24 hours. Really at this point, I have been in maintenance, at times losing and gaining 5 pounds.

Now that I'm approaching my third year of IF, I've hit a roadblock in the mornings. I find myself so hungry. I usually close my window at 7pm the night before having dinner with my husband is very important to me, which is why I don't want to break my fast in the morning. It seems lately, I can only make it to 12 hours before caving on eating something some days. What I'm getting at is, do you all have tips or advice for getting through these humps? Have you ever experienced it before? I'm disappointed in myself with the inconsistency I've done with fasting over the past couple of years, which I know leads to not getting the best results. I do love the health benefits of IF and never regret it when I do fast for at least 16. It's just some days I find myself starving, and then I cave. Any recommendations you have, I would appreciate so much. Thank you."

Cynthia Thurlow: Well, Ashley, I don't know how old you are. So, I'm going to just keep this a broad response. When a woman is telling me she really struggles to get to 12, 13,14 hours, I think you need to look at your macros. Are you getting enough protein? Are the meals that you're consuming in that feeding window, are they sufficient enough calorically to be able to fill your body? Where are you on your menstrual cycle? We know the follicular phase from the day you start bleeding up until before ovulation is a time that you can get away with longer fast. And then as you transition to the luteal phase, as you're getting closer to when you're going to get your menstrual cycle, I generally recommend women fast no more than 12 or 13 hours. So, I don't know if you're in a premenstrual situation and the end stage of luteal phase and that's why you're struggling. I would really dig into if you're feeling you're a little bit weight loss resistant, how's your sleep? How are you managing your stress? Are you getting enough macros in? Are you over exercising? So, there's a lot of variables that aren't entirely clear. And I just start to see a lot of women that get into these situations where they start to feel they're not seeing the results. So, they restrict more, they're just not feeling their bodies. And I get concerned that your body may in response to not feeling it's getting enough food and is really pushing the envelope. And if you're that hungry, I would definitely recommend breaking your fast, but also understanding that there are things you can do that could potentiate your fast, but I just feel I need more information to be more specific than I already have been. How about you, Melanie?

Melanie Avalon: Yeah, I thought that was great. I love how comprehensive that there are so many potential factors going on. I would just add to it that I think a lot of people, when they're having issues with and this is what you're talking about, but a lot people when they have issues with finding the fasting hours that work for them, they think the answer is in the fasting hours, like adjusting when they're fasting. But I personally find that looking at the food intake side of things can often be potentially just as helpful or more helpful than that. Especially when people send in questions, because we have a pattern of people who send in questions.

Some people, when they're discussing fasting and their issues, they also paint a very clear picture what they're eating. Some people don't mention it at all, it doesn't even come up in the question like this one. And I don't know this is the case but that says to me that it's possible that there's not as much of a focus on what you're eating as there could be that would possibly really, really help. So, making sure that you're getting adequate protein in your eating window, which we have a question about protein coming up. And for some people, it's looking at the macros that you're eating can actually be super helpful for satiety levels. So, some people do better with the lower carb approach, and that's what really helps them tap into fat burning and not be hungry. Some people do better with a higher carb approach, and actually, those carbs are what keeps them satiated. So, I would definitely look at what you're eating, there's a lot of potential to find something there, in addition to all of the other amazing things that Cynthia brought up.

Cynthia Thurlow: Now, it's such a good point, I think we have to look at things comprehensively. When a strategy is not working, it's okay to take a break from fasting. That's the other thing that I don't hear enough people talking about, that there are times and cycles in our lives when fasting really does well for us and times when it does not and it's okay to take a break. If you feel your body's really communicating that it's not working, there are definitely ways around that.

Melanie Avalon: Yes, exactly. Especially tying into-- I was just looking at the part where she's talking about how it's some weeks that are good, and some weeks that are harder. And I really, really wonder, you were talking about with the menstrual cycle, if it does align that way. I think oftentimes people, with the menstrual cycle, they don't make the connection that there's that connection going on there.

Cynthia Thurlow: Yep. Absolutely.

Melanie Avalon: All righty. Shall we go into our next question?

Cynthia Thurlow: Absolutely, this question is from Monica. And the subject is "Third time's a charm." "I've listened to your whole podcast. I love all the information. It has seriously been so helpful in my fasting journey. Fasting has helped me overcome so much. Major hormone imbalances and an obsession over food that is totally mellowed out with the control I feel with fasting. It's wonderful and truly life changing. My question is something I never really thought could be an issue. But I found an article that said otherwise. Can a diet focused primarily around protein contribute to insulin resistance? I follow Dr. Ted Naiman who is a huge fan of protein over pretty much all else. But if you're constantly getting the spike in insulin from protein, could not have the same effect on our tolerance of insulin as sugar does. For example, a diet of low carb high protein low to moderate fat. I'd love to hear your thoughts and research. Love you guys. Seriously keep it up."

Melanie Avalon: Okay, Monica, thank you so much for your question. Really, I got so excited about researching this question, and I did a lot of research. So, I'm so excited to talk about this. So, yes, protein does release insulin. The difference between how it releases insulin compared to carbohydrates, for example, it varies. I was looking at a lot of different literature and there are charts on different foods and insulin release. And some charts will say, for example, that beef releases more insulin than carbs. But then, something else I was looking at was saying that protein requires about half of the insulin of carbs. So, it seems to be all over the place. But the point is, they both do release insulin in substantial amounts compared to fat, which is very, very minimal.

The difference with protein is it also releases a hormone called glucagon. And you can think of glucagon as the counter-regulatory hormones to insulin. So, insulin reduces blood sugar, puts sugar into storage. Glucagon actually spurs the liver to release glucose into the bloodstream. Let's say you're just eating protein, and you are nondiabetic, and you are good with your insulin regulation in general, in theory, you would eat some protein. And because you're not eating carbs with it, this is my example, the insulin would lower your blood sugar, actually, and then glucagon would actually encourage your liver to release glucose. And then, you just have a straight-line response, and you wouldn't really have those dips and swings.

All of that said, there can be some issues, potentially with, one, the fact that protein does release insulin. So, if we are eating a lot of protein constantly, we could be getting-- it could potentially encourage insulin resistance from all that insulin release, especially in the context of if you're eating a mixed diet, and you're also getting insulin released from carbs and things like that. And then, releasing the glucagon can actually also potentially be a problem, because now not only are we releasing insulin to store carbs that we might be eating with a meal, but we're also potentially releasing glucose from the liver, which might create a longer-term blood sugar insulin issue.

On top of that, the constant release of-- protein stimulates something called mTOR, which actually, it's a growth signal in the body. And there are studies on mTOR and insulin sensitivity, and too much stimulation of mTOR constantly, might also encourage insulin resistance. And then on top of that, there's a lot of studies on BCAAs. So, those are branched chain amino acids. They are some of the potential amino acids that we can get from protein. And studies are pretty consistent that high levels of those in the blood tend to correlate to insulin resistance. But the problem is, we don't know if it's chicken or egg. We don't know if high BCAAs in the blood cause insulin resistance. Or if when you are insulin resistant, your body is unable to properly get those BCAAs out of the blood. And the studies are very conflicting and inconclusive on the BCAAs.

I found a very amazing study that literally looks at this question that Monica had. It's from July 2014 and it's called, "High dietary protein intake, reducing or eliciting insulin resistance?" And it looked at all the studies to date. So again, it's a little bit older of a study, 2014. But it was looking at the studies to date that all looked at high protein intakes in different situations, and how did it affect insulin resistance and glucose control in the subjects. And I actually, because there's a lot-- It's a very long article. I actually went through and counted, because they didn't really give a graph. I just went through and counted what they actually found. I'm going to tell you because I find it very telling.

In studies of healthy people who are not obese, who are not losing weight, so this is a short-term, energy-balanced high protein diet. Basically, just going on a high protein diet for the short term, not calorie restricted, not losing weight. Three other studies found that when they compare that to a normal diet, there was no effect on insulin resistance, so we didn't see a negative effect there. And then, one study found a benefit, so that's favorable. The second category was people who are overweight also doing the same thing. Short term, they're eating a high protein diet, but they are not losing weight. One of the studies found that when they made the protein high diet with whey protein that there was a benefit. And when I say benefit, I'm talking about on insulin resistance. One study found that there was no change, so there wasn't any difference. One study found when they use casein and whey that there was no change. Another study was six weeks, it was high protein, and the protein was from legumes and whey, and they found that it actually-- the high protein decreased insulin sensitivity, but then it actually normalized the longer the people were on it. Another study in diabetics with that setup found that the high protein improved insulin sensitivity. The conclusion was that it's inconclusive.

Then, they looked at people who are on short-term diets where they were calorie restricted and high protein, and losing weight. And in those, well, they started off by saying that most weight loss diets leading to weight loss increase insulin resistance. So, if you're on a high protein diet and you lose weight, you're probably going to see a benefit in insulin sensitivity. But it's hard to know if it's from the protein or if it's from the weight loss. They found that two studies compared high protein diets to other calorie-restricted diets for weight loss and the high protein diets had more of a benefit. One study found, comparing it to a control, so not to a calorie-restricted diet, it found a benefit. One study found that the high protein diet did not have as beneficial of an effect on Homa IR, which is a good marker of insulin sensitivity, but it did have a better effect on beta cell function and the pancreas. So, that's a little bit confusing. And then, two studies found that it was the same benefit. And then, one study found that it was looking at high protein versus high carb in a calorie-restricted situation, and the high carb was superior.

Last category, I'm almost done. And then, the section looking at long-term intake of high protein diets, one study looked at six months of people who are healthy on high protein diets. And they found that those on the higher protein diets had higher insulin resistance and more glucose issues. A collection of observational studies on diabetes found that high protein diets led to more issues. But then The Nurses' Health Study looked at low carb high protein diets and they did not find those issues. And then they actually did find that long-term intake of high protein from vegetable protein actually benefited insulin resistance. And then, there was another meta-analysis that they referenced. And that looked at 15 randomized control trials of more than 12 months on the long-term effects of diets high in protein. And it showed neither a positive nor a negative effect on glycemic control compared to diet low in protein in both healthy and insulin-resistant subjects.

Okay, sorry that that was so much information. But basically, there's been a lot of studies looking at this issue. Like I just went through all of those, the effects seem to be pretty mixed. It's interesting, because the study I was referencing, they concluded that high-protein diets and insulin action are not univocal, which means unambiguous. So basically, it is ambiguous. And that insulin sensitivity seems to have a beneficial effect in high-protein diets when people are overweight or insulin resistant, and they are losing weight. In the short term, having a high protein diet doesn't seem to really affect insulin action. But in the long term, there might be a-- or they say it seems to be deleterious when the intake is prolonged. And that this goes along with seeing high plasma BCAA levels in the blood, like I was talking about. Their ultimate conclusion is that in the long term, increased insulin secretion and consequent hyperinsulinemia might lead to reduced hepatic insulin sensitivity. Increased hepatic glucose output results in a decrease glucose control, although a direct effect in insulin action and insulin sensitive tissues can also have a role.

My thoughts stepping away from all of this is that yes, if you are doing high protein-- well, especially if you're doing high protein in the context of energy-toxic diet, a diet with too much energy in the long term, I think definitely can encourage an issue, contribute to an issue. If you're eating protein constantly 24/7, it could have those issues with mTOR. It could have basically all of these issues. In the context of weight loss, I don't think most people would need to worry about this at all. In maintenance as well. I'm not sure but I do feel for people who are doing intermittent fasting, we're getting that period during the fast of low insulin. We're getting that period of low mTOR. I think it's crucial that we get adequate if not high protein when we do eat. So basically, I really think that the issue here is energy toxicity, not protein completely. That was a really long answer. Cynthia, do you have thoughts?

Cynthia Thurlow: No, I am in awe of the research that you did. My clinical context, just thinking thoughtfully about this question is, I'm 100% in agreement that the energy toxicity, meaning you're eating too much food, is really the issue. Now, when we look at the bulk of the population, we know 92-93% is metabolically inflexible and unhealthy, it is likely not too much protein, that's the issue. It's the overall there's just too much caloric or the macros are imbalanced. It's overwhelming the body's storage sites. And it is less about protein, and more about all of the other factors. Most people, perhaps not our listeners, but most individuals here in the United States are drinking caloric beverages all day long. They're eating anywhere from 6 to 10 times a day. And when you're really looking at the degree of meal frequency, the average American is doing-- average westernized person combined with those beverages, I think that is a greater issue. And for them, if they suddenly go high protein, and they still have all these other behaviors that I've identified, then that can become a larger issue.

And it's interesting, Ted Naiman, I've interviewed and I'm very aligned with him on many, many things. And he has this amazing book that is only an electronic book, which means I don't own it, because I like having physical books for most of my things that I want to reference. But he posts a lot of fantastic content on Twitter and YouTube. And it's a great resource. And he talks about how a certain amount of protein and fats will shut that satiety, you'll hit those satiety hormones that you just physically can't consume more food. And I think that's an important distinction along with everything else that you said. But I'm so grateful you did all that amazing research. I'm just going to speak to it as a clinician, and I think it has everything to do with an overconsumption of calories, in general, that is creating this toxicity and this degree of lack of metabolic flexibility and insulin resistance.

Melanie Avalon: Yeah, what you just said is basically exactly how I feel. And I think the nuance as well is that, so say we are in energy toxicity situation on a low protein diet, the energy toxicity is primarily coming from carbs and fat. Just stepping aside, in general, energy toxicity is, I think, the issue. If you have low protein, the factor that you don't have going on in that situation, is that you're not getting that glucagon stimulation, that would be prompting the liver to be constantly also releasing glucose from the liver, which would be further exacerbating issues as well as the potential buildup of those amino acids in the bloodstream. Compared to when you do have the protein, you've got that secondary issue going on.

And I did want to throw in, because I left out one other thing because that was 2014. There was actually a 2020 meta-analysis, and it looked at 12 articles with 13 studies including patients with diabetes, and they actually concluded that a high protein diet does not significantly improve glycemic control and blood pressure. They didn't say that it hurt it, they just said it doesn't improve it. But it can lower LDL, TC, TG and Homa IR levels in patients with type 2 diabetes. Further studies are needed to clarify the effects of high protein diet and glycemic control, insulin resistance and blood pressure control and type 2 diabetes. I just want to throw that one in there because I left it out.

But I'm glad you brought up Ted Naiman, I love him, we can put links to the episodes that we've had with him. I also really love Marty Kendall. He had a really good article on the glucagon aspect of this that I was reading, and he actually referenced Ted Naiman in that study as well. All that to say I agree with-- what you just said is what I agree with that. I think the issue is the energy toxicity.

Cynthia Thurlow: No, it definitely makes sense.

Melanie Avalon: Okay, I don't know if Monica expected that long of an answer. [Cynthia laughs] All right, we have a question from Jessica, and the subject is "Menopause, HRT, etc." Jessica says, "Hi, I love this podcast and I learned so much about IF. My doctor advised me to start IF a month ago when she put me on HRT. I'm 37 and still breastfeeding my daughter aged one, but I'm also postmenopausal as my ovaries were removed in December. My doctor advised HRT because my estrogen was unsurprisingly very low, and my DHEA and testosterone were very high. I've been doing IF starting at 16:8 a month ago, and now usually doing 18:6 and sometimes 20:4. I have not lost a single pound. My clothes do not fit differently. I am at my highest weight ever and getting so discouraged every time I step on the scale.

I have now been on low doses of bioidentical estrogen and progesterone for a month while doing IF. And although I feel some benefits, it's helped some digestive issues. I need the scale to move in order to feel my health is improving. Losing even a few pounds would give me hope, but it is just not happening. How long do I stick with this before it's time to admit it is not working for me? I'm also a vegetarian, but I sometimes eat the occasional fish. I'm reading that the research on IF for women is mixed, and it may have negative consequences for postmenopausal women. Is it possible this just isn’t for me? I hope that's not the case. Because this is the only diet, I've ever tried that I felt was sustainable. Thanks in advance, keep up the good work."

Cynthia Thurlow: Ah, Jessica, you have a lot going on. Oh, my goodness. You're still a very young woman, and we know women that have their ovaries removed before the age of 42 are at greater risk for developing cognitive issues. So, I'm grateful that your doctor is being very proactive and considering hormone replacement therapy. My concern is, and I'm just going to start from the top, I'm not in agreement with women breastfeeding or being pregnant and fasting. You're wanting to lose fat, but your body is still feeding a baby. And I'm sure if she's one, she's probably eating a lot of solids. And so, her breastfeeding might be brief and just a few times a day. But just something to think about in the position that you're in, you're giving your body mixed signals. You want it to lose fat, but you still want to be able to sustain being able to breastfeed, and I find for most women while they're breastfeeding, it's harder for them to lose body fat. So, that's number one. Since you're so young, I'm curious to know why your ovaries were removed at such a young age because that's very significant.

You're mentioning that your testosterone was high. The question is why. Did you have polycystic ovarian syndrome? When I start thinking about the reasons why women can have high testosterone, that's almost always the first thing I think about. Does your husband take supplemental testosterone? Probably not, because you're both very young, but you can sometimes get exogenous exposure that way. Just in thinking about the bioidentical hormones, it could be a combination of too much stress on the body, breastfeeding, fasting. Going into menopause is a big adjustment, and you have surgical menopause, meaning the average age of a woman in the United States to go through menopause is 51. You're 37. So, you're very, very young. And so, from my perspective, it's trying to get a sense from what you've shared as to what could be going on.

The other thing that I get concerned about is most vegetarians in my clinical experience consume too many carbohydrates, not enough protein. And you really have to work at that very diligently. If you're eating very limited, animal-based protein, hopefully, you're eating some eggs, which will make that easier. But the challenge is, if you're trying to fuel weight loss and you are vegetarian, you're very likely overconsuming carbohydrates. And then, you're also breastfeeding, and your body needs a little bit of extra fuel to be able to make that happen. I wrote a whole book about women and fasting.

And I generally will suggest the women check that out. There is research on postmenopausal women. And I find the women that generally do the best are the women who have stable hormones, meaning, when you're no longer menstruating, your hormone levels are stable, much more stable day to day, week to week than a woman who's still in peak fertile years, or even a perimenopausal woman-- there's a lot of good research that women can do very well in menopause, with intermittent fasting, provided that they're sleeping high quality sleep, they're managing their stress. And as a new mom, it's not unstressful to have a little baby at home and then stressing about trying to lose weight. I mean, those are two big things, eating anti-inflammatory nutrition, and really thinking about, things that fuel insulin sensitivity. And I think about walking after a meal, and lifting weights and things like that.

So, there's a lot to unpack here, I would give it more time. If you're breastfeeding, you need to give yourself some time. I used to always say six months was always that time period that I felt most of my patients got to a point where they were starting to see some weight loss, 12 to 18 months. And if you're still breastfeeding, it's going to make it a whole lot harder to lose weight. So, please give yourself some grace. Make sure you're getting your hormones tested, make sure you've got a DUTCH as well as serum blood labs. I think that would be very helpful. And the other question that dovetails into that is why is your testosterone so high? Did you have PCOS? What was the precipitant for removing your ovaries? That's a pretty drastic surgery for such a young woman. I would imagine there's a good reason, but just not a reason that's entirely clear to me right now. What do you think, Melanie?

Melanie Avalon: Well, I thought that was absolutely amazing and comprehensive. That was one of the takeaways I really took away from reading your book, Intermittent Fasting Transformation, was the difference with fasting in pre-menopausal and postmenopausal women and where do you think this idea-- because people ask this a lot or say this, that there are negative consequences for postmenopausal. But have you seen that? I mean, would the concern be I guess sarcopenia, not getting enough protein? I'm just wondering where this idea is coming from.

Cynthia Thurlow: I think there's a degree of fear mongering This is why I'm not a fan of OMAD. And that may upset people but I'm going to just say it, you just can't get your macros in. And once you're going through perimenopause, and menopause, physiologically, we are just much more at risk for muscle loss and the way that you need to think about how important and-- Gabrielle Lyon has been on your podcast, she has been on my podcast, she's a really close friend. I tell her all the time that her work completely changed everything that I talked about. But you want to think about muscles as a glucose reservoir. They're critically important for being metabolically healthy. And as you are losing muscle, and that's being replaced by fat--

I always talk about the filet, which is young muscle. Melanie has young muscle Melanie, so Melanie is a big fillet. And I'm 51, so my muscles, if I don't work really hard, are going to look like a ribeye and a ribeye is delicious. But we want to be a filet for as long as we can be. And I'm not talking about aesthetics. I'm talking about musculature, it's so important. And the concern I get is when postmenopausal women, perimenopausal women are just bucking this trend of, "I'm only hungry for one meal a day and that's all I eat," I just have to remind them, one of the reasons why you're not more-hungry, is you're starting to lose lean muscle mass. And as Gabrielle says, "You are not overfed, you're undermuscled." So, it's really important to understand that I think a lot of the concerns and fear about menopausal women is largely a byproduct of this concern that they are going to lose muscle mass if they're not eating at least two meals a day, we're not talking about 6 meals a day, or 10 meals a day, which I eat two meals a day so that you can get enough protein in your diet.

The other thing that I think is important note is that we're de facto less tolerant of stress as we head into perimenopause and menopause. It's a byproduct of the loss of progesterone from our ovaries, as our adrenals are stepping in to help support our body, we are just not as stress resilient. That doesn't mean we can't manage stress, we don't manage it as well. And so, I think on a lot of levels, there's this concern that if women head into their 40s, and 50s and beyond, and they're overfasting, overrestricting, not exercising or doing the wrong types of exercise, that they can put themselves at risk for a lot of inflammation, a lot of bodily stress. But I sometimes feel menopausal women have an easier time because they don't have to deal with the factors of a menstrual cycle and follicular phase and luteal phase. I would say men and menopausal women can sometimes have the easiest time fasting of all because they don't have to worry about this biology of procreation and conception and fertility and infertility that younger women have to worry about. But I do think it's a huge problem.

In fact, I'm not going to say this person's name, but there's a person who just had a book come out and they love to fearmonger about women and fasting. And I've had to have this discussion quite a bit. And I don't want anyone to perceive that. If you're sleeping well and you're dialing in on your nutrition and you're managing your stress and you're fasting for your cycle and you're not overexercising, that fasting can't be a part of or eating less often, can't be part of your strategies that you use to feel good about navigating whatever stage of life you're in. I think a lot of that comes from well-meaning people who don't really know what's going on. That's my feeling.

Melanie Avalon: I cannot agree more. It's actually similar or relates to the findings speaking of what you're talking about earlier with protein, on protein and longevity. There are so many people, researchers and such like Dr. Valter Longo, who I've had on the show-- he's actually been on this show, and he's been on the biohacking podcast, but he and people in his sphere are very much pro low protein for longevity up until, I think, age 60. And then, you need higher protein. So, I think that does relate to everything Cynthia was talking about, about when you are at that older age and the more difficulty it is to create and maintain muscle, women in particular really need the higher protein when they're older. I don't think that should be lumped in with the fasting, which I think can happen. It just might be like Cynthia was saying that you need a longer window to get in that adequate protein intake if you're not like me where I eat all the protein.

Cynthia Thurlow: The unicorn, but I think that's one of the reasons why I love podcasting with you as we really speak to such a wide age range of women. And I think that's really important because if we were both 50 somethings or if we're both 30 somethings, we would not necessarily totally represent our demographic, right?

Melanie Avalon: Yeah, exactly. It's funny before I even started the show, way back, I remember brainstorming about what did I want the show to look like. And at first, I was like "Oh, I want to cohost with somebody like my age. And it'll be two girls having wine night, two young people." But when I met Jen, I was "Oh, this is actually much more appropriate," because it's just so much helpful to give the broad perspective, and then it's even better when we're friends as well. It's all the good things.

Cynthia Thurlow: Exactly. And I think it's important for people to understand that there's a genuine camaraderie here. So, we can both benefit from our own experiences. My kids know who Melanie is. When we talk about Melanie's eating window, and her sleeping habits and how different we both are, and that's the beauty of it is that there's listeners who very likely-- there might be someone who has a long, evening eating window and stays up really late-- And I think, it's only when I was traveling in Europe that we overlapped at the same time, like we were awake for the longest stretch of time at the same time. I was like, "This is cool."

Melanie Avalon: Yeah. It's funny, I get DMs from people because I do think my approach is very rare. But there are? I know you guys are out there who actually do it very similar to me, and quite a few people DM me, and they're just like, "Thank you for letting me know I'm not alone in my crazy late night, feast every night." So, we are out there, but it definitely doesn't work for everybody, that is for sure.

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All right. Shall we answer one more question?

Cynthia Thurlow: Absolutely. This is Mary, "Prescription meds breaking fast." "Hello, I've just begun IF." So, her eating is either 19:5 for two days or 20:4. "I've long abstained from between meal eating, so this was a fairly easy transition for me. I am determined to have clean fast. However, I saw a comment today on Facebook regarding melatonin, and the word was that it does contain sugar, so realistically breaks the fast. I have a long list of prescription meds. So far, I've looked at four that are must-haves, and they all have that same ingredient. My feeding window is 12:30 to 4:30. I can take my evening pills right at 4:30 and some of my AM pills right at 12:30. But some must be taken 12 hours apart. My question is, if I take the must-haves when I wake up, does that wreck my clean fast? Eager to hear. I want to do this right. Thank you for your time, Mary."

Melanie Avalon: All right, Mary, thank you so much for your question. So, something to clarify, because I can see how this can happen. You talked about how you heard melatonin, and it contains sugar, and so, it breaks the fast. And maybe this goes without saying but with something like melatonin, which is not a prescription, there are many brands of melatonin, and they do not all contain sugar. So, melatonin does not equal sugar, does not require sugar to be taken. For melatonin, for example, you can find a melatonin that is fast friendly. We love melatonin from MD Logic for example. So definitely check them out. You can use the codes, MELANIEAVALON or CYNTHIA, to get a discount on that I know Cynthia in particular has really benefited from that melatonin. So that's supplements like non-prescriptive supplements, you can usually find a version that is clean, fast friendly, especially when it's not a prescription because there's normally lots of versions of it.

When it comes to prescription medications, if you have to be taking your prescription medications, you have to be taking your prescription medications. Some of them might contain ingredients that break the fast like she has found out. I'd be curious what she found in it that was-- I'm wondering what the sugar ingredient that she's thinking. I'm wondering if it's something-- I'm just wondering what it is exactly. There are a few things. One, I think a lot of people don't realize this, but this is actually an option. You can actually get a lot of prescription medications compounded, I actually do. If you have a compounding pharmacy that you like and can work with, they can often make compounded versions of your medication with the exact fillers that you want, or even no fillers. It's not always a possibility. And sometimes if it's a possibility, it's extremely expensive, so then it's not really a possibility. But for some of the medications, it is a possibility. I've done that in the past for things.

If that's not the case and you need to go with the traditional prescription form, there are a lot of generic versions of a lot of prescription medications. You can look up the prescription and you can try to find the one that is the most "fast friendly." It does take a little bit of detective work, I'm thinking of little detective emoji in my head. But that is an option. And you can talk with your doctor if you want a specific generic version prescribed. All of that said, if you need to take the prescription medication and you cannot find a clean, fast friendly and you cannot get it compounded. It's okay, [chuckles] you have to take your medications when you have to take them. It's not like this is actual food. I'm not giving a greenlight to taking in minute amounts of sugar or anything that in general. But when it comes to medication, you have to take your medication. Don't stress about it. It will be very minimal, if anything. Those are my thoughts on medication. Cynthia?

Cynthia Thurlow: The irony is I have 45 cohort going right now, and we had our first group call. And that was the first question that I was asked today. And here's the thing, if you have to take a medication, you have to take a medication, period. There should be no stress about, does it break your fast, does it not breaks your fast? I'm always very transparent talk about the fact I take now compounded thyroid medicine, and I take that during my fasting window and that does not break my fast. Now, the issue with generics, and people may not know this, but you can get these tremendous variances. There are generics you can get sometimes like 20% variants. As an example, before I was taking compounded progesterone, I would sometimes wonder why some nights I'd sleep really well and some nights I wouldn't. My functional med doc actually pointed out, "Well, you realize, you probably remember this but for generic medications, even though it's a bioidentical, you still have this variance." And so, I would just state that-- sometimes the trade medications that you pay a little more for-- and by no means am I telling people to break their budget to do this, but if you feel you don't do as well on a generic, just understand it can be 20% different than the trade product. I had a lot of women, especially my thyroid patients, that would tell me they would not take generic Synthroid. They only took regular Synthroid because they had intolerances. I had patients on antihypertensive, so medications for their blood pressure, same thing. We're all individuals but please do not let the concern about breaking a clean fast be the reason why you perceive that you have to do all these different things to me make this work.

Now, there should be no sugar in melatonin. And if there is, then I would definitely look for another option. I speak very openly that the two options I use are Sandman, that's a whole other special conversation about that supplement. But the MD Logic melatonin is more efficacious, meaning it's stronger than the Designs for Health product I'd been using for several years, and I even used on myself as well as my patients. One capsule of MD logic was equivalent to three of the Designs for Health sustained release. To give you an idea, it's very cost effective, and I'm not sharing that to sell everyone on that brand, but just to share that's what works for me. Sandman is a per rectal melatonin, but it's also largely cost prohibitive for the average person, I probably use it twice a month. But with that being said, please don't let that be a concern. Now, if your supplement has sugar in it-- there was a woman in my other group who had a product that had 40 grams of sugar and 30 grams of carbs. And I was like, "First of all, you need to throw that in the garbage."

Melanie Avalon: In what? Supplement?

Cynthia Thurlow: Yeah, there were gummies. And I said, "Okay, well, a gummy is going to be full of sugar, because it's going to be soft and--" Anyway, a whole separate conversation. But the point of what I'm sharing is, we want to try to find the cleanest options that are out there. Things without gluten and dairy and grains and soy, just be diligent when you're selecting supplements to try to find really high-quality products. Yeah, that's my ramp. But please don't let concerns about your medication breaking your fast keep you from taking medications that you are prescribed and that you need.

Melanie Avalon: That's so fascinating. I know you said you've seen it in hypertensive medications as well. Do you find it is more the hormonal supplements where that's an issue or is it just across the board?

Cynthia Thurlow: Well, it's interesting, because many years ago, when I was taking oral contraceptives, I remember when I was a student at Hopkins, I had this one brand of oral contraceptives. And I also had mild phenotype PCOS, I had no idea why I had these crazy wild periods. Well, it's because I had PCOS and that's why I initially went on the pill. And the student health center was "Oh, we've got the generic version of what you're taking." I went on the generic and gained 10 pounds. And I remember them saying, "Oh, there's nothing different in this." And then, I remember talking to my faculty, and they were like generic is exactly that. They only have to have 80% of the formulation the same.

Melanie Avalon: Legally?

Cynthia Thurlow: Yeah, and you can have different fillers. There's lots of things that happen with these medications that I used to say-- Some people do fine with the generics, let me be clear, there's nothing wrong with generics. But I think there are definitely people who are much more sensitive to additional fillers and different formulations of medications. And so, that's where I think it's important to just have the conversation. If you're doing fine on what you're taking, great. If you're not, investigate what other options are available.

Melanie Avalon: Wow. It's interesting, because I had sort of vaguely wondered that in general about the generics, but I hadn't really looked into it.

Cynthia Thurlow: Yeah, up to 20%.

Melanie Avalon: Um, it's concerning.

Cynthia Thurlow: Yeah.

Melanie Avalon: Well, thank you. That's very valuable information. Thank you for sharing.

Cynthia Thurlow: You're welcome. It'd be a little depressing for everyone to hear. But the irony is one of my pharmacist friends and one of my doctor friends just happened to say that to me the other day, and I was like "Oh, my gosh, I forgot that. It's so true. It makes complete sense."

Melanie Avalon: Wow, wow, wow. Well, thank you.

Cynthia Thurlow: You're welcome.

Melanie Avalon: For listeners, if you would like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. The show notes for today's episode, which are going to have a lot of links, as well as a full transcript, will be @ifpodcast.com/episode286. And then, you can get all the stuff that we like at ifpodcast.com/stuffwelike. And you can follow us on Instagram. We are @ifpodcast. I am @melanieavalon, and Cynthia is @cynthia_thurlow_. All right. Well, this has been absolutely wonderful. And I will talk to you next week.

Cynthia Thurlow: It sounds good.

Melanie Avalon: Bye.

Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team. Administration by Sharon Merriman. Editing by Podcast Doctors. Show notes and artwork by Brianna Joyner. Transcripts by SpeechDocs. And original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Sep 11

Episode 282: EMF Protection, Insulin Levels, IF Weight And Fat Gain, Heart Palpitations, Electrolytes, Hydration, Digestion Changes, And More!

Intermittent Fasting

Welcome to Episode 282 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get Free Chicken For A Year!!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

SHIELDYOURBODY: Use The Code Melanieavalon For 15% Off Sitewide At melanieavalon.com/syb.

The Melanie Avalon Biohacking Podcast Episode #122 - R Blank

ATHLETIC GREENS: Get A FREE 1 Year Supply Of Immune-Supporting Vitamin D AND 5 FREE Travel Packs With Your First Purchase At athleticgreens.com/ifpodcast!

Listener Q&A: Erica - Eating and insulin levels

Listener Q&A: Kathryn - IF Weight and Fat gain

The Melanie Avalon biohacking Podcast Episode #45: Glenn Livingston, Ph. D.

Ep. 140 – The Nature of Bingeing: How to Break Out of the Food-Prison with Dr. Glenn Livingston

JOOVV: For A Limited Time Go To joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount!

Listener Q&A: Lydia - IF and Palpitations

LMNT: For A Limited Time Go To drinklmnt.com/ifpodcast To Get A FREE Sample Pack With Any Purchase! Learn All About Electrolytes In Episode 237 - Our Interview With Robb Wolf!

AvalonX Magnesium 8: Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist, And Use The Code Melanieavalon For 10% On Any Order At Avalonx.Us And MDlogichealth.Com!

Simply Hydration: Magnesium-Charged Electrolyte Concentrate for Rapid Hydration

Listener Q&A: Sarah-Lynn - Positive side effects

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 282 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this podcast do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Okay, friends, you can take chicken breasts off your grocery list. ButcherBox is offering our listeners an incredible deal that they have never offered before ever. Free chicken for a year. Yes, you can get two pounds of free-range organic chicken breasts for free for a year. I am not making this up. There is a reason we adore ButcherBox. They make it so, so easy to get healthy, delicious, humanely raised meat and sustainable seafood that you can trust. They deliver 100% grass-fed, grass-finished beef, free-range organic chicken, heritage-breed pork, that's really hard to find, by the way, and wild-caught sustainable and responsible seafood shipped directly to your door.

When you become a member, you're joining a community focused on doing what's better for everyone. That includes caring about the lives of animals, the livelihoods of farmers, treating our planet with respect, and enjoying deliciously better meals together. There is a lot of confusion out there when it comes to transparency regarding grazing practices, what is actually in our food, how animals are being treated. I did so much research on ButcherBox. You can actually check out my blog post all about it at melanieavalon.com/butcherbox. But I am so grateful for all of the information that I learned about their company. All of their beef is 100% grass fed and grass finished. That's really hard to find. They work personally with all the farmers to truly support the regenerative agriculture system. I also did an interview with Robb Wolf on my show, The Melanie Avalon Biohacking Podcast, all about the massive importance of supporting regenerative agriculture for the sustainability of not only ourselves, but the planet. This is so important to me. I'll put a link to that in the show notes.

The value is incredible. The average cost is actually less than $6 per meal. And it's so easy. Everything ships directly to your door. I am a huge steak lover. Every time I go to a restaurant, I usually order the steak. Oh, my goodness, the ButcherBox steaks are amazing. And their chicken is incredible, humanely raised, free range, organic and you can get it free for a year. Get two pounds of free-range organic chicken breasts for free in every order when you sign up at butcherbox.com/ifpodcast. That's two pounds of free-range organic chicken breasts for free in every order when you sign up at butcherbox.com/ifpodcast. Claim this deal at butcherbox.com/ifpodcast. If you've been wanting to try ButcherBox, now is the time. We will put all of this information in the show notes. 

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense, because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting. It's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disruptors, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup maybe playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health, and they affect the health of our future generations. That's because, ladies, when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years. 

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later, maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have Countertime for anti-aging, Countermatch for normal skin, Countercontrol for acne and oily prone, and Counterstart for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check on my Instagram to see what it looks like. Tina Fey even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready.

They have so many other products, deodorant, shampoo, and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20, to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out. And you can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well. 

And lastly, if you're thinking of making clean beauty and safe skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like the Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now, back to the show.

Melanie Avalon: Hi, everybody and welcome. This is Episode number 282 of The Intermittent Fasting Podcast. I'm Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, Melanie.

Melanie Avalon: How are you, Cynthia?

Cynthia Thurlow: I am doing well. I've got both my kids back in school.

Melanie Avalon: Oh, nice. More me time for you? 

Cynthia Thurlow: Well, at least they're not laying around the house. That's the one thing about teenagers is that they're like bears. They come out to eat, they come out to be taken places, and then they spend a lot of time in their rooms sleeping. And so, at least now during the day, my husband and I have a completely immaculate house, unlike when they're home. They're essentially savages. So, they're at least gone during the day. They're in school. They're being intellectually stimulated. It's all good.

Melanie Avalon: That makes sense. That's one thing I miss about being a teenager. It was okay to sleep like hours and hours and hours.

Cynthia Thurlow: It's interesting. My mom came to visit. My mom was very militant. We weren't allowed to sleep in, ever. And so, she was like, "You let your children sleep?" And I said, "Yes. Because they stay up late, and they need the sleep." [laughs] So, that's always the place I come from. I'm like, "As long as they get their work done, and they get their chores done, and they have good grades, I don't mind if they sleep," and it's really not an inconvenience to me. My husband and I go have half a day to ourselves before they wake up.

Melanie Avalon: That's the way my mom was growing up as well. That is something to be grateful for all the little things. Because that would have been miserable, if she had made us get up.

Cynthia Thurlow: Oh, my mom was just tough. I think because she was a healthcare professional, and was up early rounding, and seeing patients, and so, from her perspective, she had to be up, we should be up as well. [laughs] 

Melanie Avalon: Growing up, we would go to Sanibel Island in Florida every summer and I would always have a friend come with me. And it was funny, because I loved when I had the friend that had the same sleep schedule as me. We would both sleep until 2 PM. Because some of my friends were early morning birds. So, they would get up at 10 AM and have to wait for me for couple hours.

Cynthia Thurlow: So, this is not a new lifestyle.

Melanie Avalon: Oh, no, no. I think I've talked about this before on the show. I feel bad about it. I feel I should be a morning person. And every time I talk to my mom, my mom's like, "Melanie, you've always been a late-night person. You will always be a late-night person. Just accept it."

Cynthia Thurlow: We are very opposite.

Melanie Avalon: We are and I'm jealous.

Cynthia Thurlow: [laughs] No, I was thinking to myself, if we were ever in the same location at the same time, what would be the optimal hours we would be up at the same time? I'm like, "From 12 to eight." 

Melanie Avalon: Yeah. 12 is pushing it. [laughs] 1 to 8, 1 to 9. Is 9 pushing it for you?

Cynthia Thurlow: 9 is pushing it for me. Maybe 30, I'm generally like, "Okay, I want to go." I want to get on my PMF mat and start getting ready for bed.

Melanie Avalon: So funny. The socially acceptable hour that works for me to be like social is 7 or 8. Because most people are still like, they'll get drinks at 7 or dinner at 7. I know 8 pushes it for some people. But in any case, we have something exciting to share with listeners. Actually, two exciting things. One, would you like to share the winner of your giveaway?

Cynthia Thurlow: I would. The winner of our giveaway was Louise Sparks. So, we will be sending out your goodies within the next week. And I just wanted to take an opportunity to thank everyone for the wonderful, wonderful reviews that were left for the book. I'm so very grateful to be part of this community and very appreciative of everyone that submitted entries. 

Melanie Avalon: Yeah, it was really wonderful to read all of the reviews that, because I got to see them as well obviously being emailed in. It's just so wonderful how supportive, and kind, and just wonderful everybody can be. So, thank you. And what was the price? 

Cynthia Thurlow: We had very generous individuals, companies that donated products to the book launch. And so, there were some products from designs for health, some Redmond's products, all sorts of fun goodies. It was overwhelming how generous these companies were. And so, there were so much that was donated, we wanted to extend another option to share it with individuals that had read the book and loved it. So, thank you again, Louise Sparks.

Melanie Avalon: Awesome. Awesome, awesome. And then another exciting announcement. This is an opportunity to both learn very important things and also win very exciting things. So, okay, I'm so excited about this. I have a dear friend, R Blank. I've had him on The Melanie Avalon Biohacking Podcast. Cynthia, have you connected with R before?

Cynthia Thurlow: I have not definitely like on my radar, though.

Melanie Avalon: He's fabulous. He has a company called Shield Your Body and they are the global leader in laboratory tested EMF protection products. And okay, so, I am so passionate about this EMF situation. And it's interesting, because I feel people are skeptical of the health effects of EMF, but there have been-- Well, first of all, the World Health Organization lists EMF as a class to be carcinogen. So, this is not something that's woo-woo or not real. It's literally a carcinogen. And there's been thousands of high-quality peer reviewed scientific studies looking at EMF radiation from things like our cell phones and our air pods, and they found negative health effects like sleep disruptions, even infertility connections to Alzheimer's, obviously, connection to cancer. It's a really big deal. If you want to learn more about it, definitely check out my interview I did with R on the Melanie Avalon Biohacking Podcast. I'll put a link to it. 

The reason I really, really like what he's doing is, he is all about the science of everything and what is actually something to be concerned about what's not something to be concerned about, how can you actually mitigate it, and what is practical. He's not going to tell you to never have a cell phone or never use Bluetooth. Although, I think he personally, probably never uses Bluetooth. I don't want to put words in his mouth. But he's very good about making everything approachable and practical, which is why he has this company, Shield Your Body. And they have all these incredible products that will help protect you from EMF and they're tested, which is so, so key. But in any case, the exciting announcement. So, this episode airs September 12th. And on September 22nd, Shield Your Body is actually having EMF Radiation Safety Day. This is the fourth year that they've done it. It's actually on Faraday's birthday, so the guy who invented the Faraday cage. And the purpose of the event is just to spread awareness and help people learn more about the dangers of EMF exposure, how they can really shield themselves and protect their health, the health of themselves and their family. 

And so, basically, they offer tons of free, yes, free and easy ways to reduce your EMF exposure. And it actually according to them all comes down to two key rules. And no, I'm not going to tell you what those two key rules are. You have to get them for free. To get those two key rules and to be a part of Radiation Safety Day, because when you go to get all these free resources, you'll actually be entered into a giveaway to win a Shield Your Body canopy worth $2,000. So, that's just incredible. You can potentially win that canopy and in addition, they're going to be giving a lot of other prizes as well. So, you can go now to get the free resources and to enter to win. You will go to shieldyourbody.com/rsd. Again, that stands for Radiation Safety Day. And you can enter now all the way up until September 22nd. September 22nd is when they are going to do the raffle drawing. 

And in addition, while you're at Shield Your Body or just in general, if you would like to purchase any of their products, you can use the coupon code, MELANIEAVALON, and that will get you 15% off. I love their stuff. I'm actually right now using their wired headphones that do not have Bluetooth exposure. So, that's great. I really recommend their pad that goes underneath your laptop. If you are sitting with a laptop on your lap, again, there's studies showing that EMF exposure can affect fertility. So, it can be really, really important to have something like that protecting you from your laptop. They have bags, they have some apparel like a beanie, they have stuff for your kids. So, definitely, definitely check it out. Maybe you'll win that canopy.

Cynthia Thurlow: Ah, that sounds amazing.

Melanie Avalon: How do you feel about EMF exposure, Cynthia?

Cynthia Thurlow: Well, we had our house evaluated before we built it, the property and the geothermic forces underneath the house. And we have special material that was laid underneath our floors. And we have special-- [crosstalk] 

Melanie Avalon: I'm so jealous.

Cynthia Thurlow: [laughs] We didn't do a canopy in our bedroom. because I kept explaining to my colleague, I was like, "I am going to have teenage drivers. I can't be in an environment, where if there's an emergency and they're driving that I can't have my phone working. Maybe if they were a little younger, it'd be different." I would say, we probably did 50% of what was recommended. To do it fully 100% would have meant that there would have been absolutely no Wi-Fi at all upstairs in our bedrooms. And I was like, "That's not entirely realistic." We do shut down the Wi-Fi at night much to our kids' disappointment, especially because they are bears and they're up all night. But this house was definitely designed to be very conscientious. We have ethernet cables. All of our computers are wired into the wall.

Melanie Avalon: I am so happy right now to hear this. Same. I use ethernet. I'm on a wired computer right now. I turn off Wi-Fi at night. And we've talked, you know the EMF product that I'm creating, right? The issue that you just expressed, which I know is an issue for a lot of people. You need to have your phone on at night. So, what do you do about that? I'm actually working with R right now. We're working on a cobranded product. I am so excited. And it's going to be something to address that exactly. It's going to be something that you put on your nightstand, and you'll be able to put your phone in it, and it will shield you from your phone, but then you'll still be able to receive calls and you'll be able to charge your phone. I'm so excited. Stay tuned for that. But in the meantime, definitely go to that link, shieldyourbody.com/rsd. Enter to win the giveaway. Learn the two key rules to protect yourself and so much more.

Cynthia Thurlow: That's really important. And here's the one thing that I don't know, if listeners realize that some of us are much more sensitive to EMF. I'm a canary in a coal mine. And so, for me and my last house in Northern Virginia, there were so much external radiation and EMF that was coming into that house. As soon as we moved into the house, I stopped sleeping. And when Brian Hoyer came out and evaluated the house, he looked at me and he said, "You realize when EMF is this high, it upregulates cortisol and this is why you're not sleeping." And so, I just started to cry, because my husband thought I was nuts. But I'm trying to explain to him that there are those of us that are just much more sensitive to it and there are a lot of data centers in that part of Northern Virginia almost as much as what they have on Silicon Valley. And so, from my perspective, I think awareness is key, not to scare people, but just to bring awareness and then finding strategies that fit your lifestyle, I think is really important.

Melanie Avalon: Actually, when Gin was on the show, she had a whole experience, because she's always moving. She moved into a house and started getting a lot of sleep issues. And she thought it correlated to some other factors. And then when they were moving, she realized that her bedroom was right by the power grid and was thinking that that probably had something to do with it. It's so true. It affects people more than others. I actually also had Joseph Mercola on the Melanie Avalon Biohacking Podcast to talk about it as well. One of the really shocking things and this is just frustrating and it's maybe like the processed food industry or something. But the studies they use to set up safety regulations for cell phone use, the models don't match reality. The way they test for safety is not the way we would be using our phones. Normally, it's not the exposure we would be exposed to. It's very, I don't want to say rigged, but there's a way they keep continuing to make these devices that are having these health effects and it's really binging the rules and it's upsetting. But yes, there are things you can do. shieldyourbody.com/rsd. 

Cynthia Thurlow: Cool. 

Melanie Avalon: Shall we jump into some questions for today?

Cynthia Thurlow: Absolutely. This is a question from Erica. Subject is: "Eating and insulin levels." "I recently had a short conversation with Dr. Herring about insulin. Somebody on his Facebook page was talking about glucose and how if they have creamer in their coffee, their glucose doesn't rise after 30 minutes. I said, "If it doesn't rise, it's because insulin has been released and done its job." Dr. Herring then came in and said, "If insulin had done its job and the glucose reading would be lower." I asked, "Let's say you start with a fasting reading of 5 in just anything wouldn't a level go up to 7, insulin brings the reading back to a 5 or thereabouts. Are you saying that the levels should go even further down say, 2 or 3?" He didn't answer that question. Nearly three years living intermittent fasting now, thanks to you two for keeping me motivated via the podcast while I walk. I will never stop as it's just my normal now. 50 kilograms gone. Regards, Erica."

Melanie Avalon: And Erica is from Western Australia. 

Cynthia Thurlow: Perth is beautiful. 

Melanie Avalon: Oh, you've been there?

Cynthia Thurlow: I have not. But my boyfriend before my husband, who my husband has actually met, was from Perth and the photos, they had a farm, they were just beautiful. It's considered to be one of the most isolated areas of Australia in the world. But the photos were gorgeous. One day, I will get there.

Melanie Avalon: Oh, wow. I want to look up pictures. I love looking at pictures of places. That's so cool. Well, Erica, first of all, congrats on your success with the weight loss and thank you for your question. And so, I think this is good question because it taps into a lot of broad concepts that I think people get confused about or have questions about. So, I can speak briefly to it. Your blood sugar levels at any given time, there are so many factors that are affecting that. What's really crazy to think about-- It's actually mind blowing, if you actually think about it. The amount of blood sugar, so like, she's using millimoles to measure a blood sugar. But we in the US measure in the 90s or 80s, or one hundreds, that correlates to a very small amount of blood sugar. Like a teaspoon, I think is what I've heard. And so, it's really crazy to think that we will eat a bolus of carbs, like a massive amount of carbs. 

And when people who are diabetic can have issues. But even people are prediabetic, even that the levels might go high, but they never equal the amount of sugar that you're eating. The body does a really good job, even people who struggle with high blood sugar at keeping that regulated. Stepping back just to paint a broad picture, obviously, you can take in carbohydrates or sugar and that is a source of sugar entering your bloodstream. Or, your liver can release stored sugar or carbs in the form of glycogen into the bloodstream. Actually, fun fact, the majority of the blood sugar that you have in your bloodstream, including and diabetics is not from what you're eating. It's from the liver releasing it, which is just something interesting to think about. The third way would be the liver can actually make sugar, if it doesn't have sugar. Those are the three inputs. 

And then on the flip side like Erica was talking about, what's removing the sugar from the bloodstream is insulin, which is being regulated by the pancreas. And so, there's a lot of nuances here. And so, if you're taking in something that has carbs in it, presumably, that's going to lead to a blood sugar spike, which would go down, because you have insulin. In this case, she's talking about creamer in the coffee. And so, it's hard to know the actual creamer. So, this could be a creamer with carbs in it or it could be a creamer without carbs in it. If it had carbs in it and the glucose didn't rise, then yes, presumably, insulin put the carbs into storage and so they're not in the bloodstream. If the creamer real didn't have many carbs and it was fat-- And this is something that I think people get confused about as well. Fat is very easily stored. It doesn't necessarily require insulin to be stored. A reason that you could take in fat and not see a blood sugar rise and it's not because you put energy in your bloodstream and insulin got rid of it, it could be that insulin just wasn't even required. 

And the reason I'm saying all of this and sorry, if this is a lot of information, people are so unique. They'll do studies, where they have people basically getting a continuous infusion or injection of both insulin and glucose, and they can see how much insulin is required to keep the glucose level. Basically, how much insulin do you require to take in this blood sugar and not see any effect, any bump in your blood sugar level? And the reason that's important and the reason it relates to Erica's question is, that's going to be different. It's not like everybody requires x amount of insulin to take care of x amount of carbs. In this situation where the glucose didn't rise and she's asking, well, it should have dropped lower, it's completely an individual basis. Some people, they might release the perfect amount of insulin that they perfectly store it and it doesn't rise. Some people might release a little bit more insulin. And so, it actually drops lower than before, which would be the situation she was talking about the end. Or, if there weren't even carbs in it and it was just fat, which is a possibility. Insulin might not have been released at all, because in some wasn't required and there wasn't bump. That's a lot of information. Cynthia, thoughts? 

Cynthia Thurlow: No, I think you did a beautiful job. But the big takeaway is, fat has a much more negligible impact on blood sugar response. And so, that could explain why there hasn't been-- There's this negligible response. And so, I think it's important to delineate and discuss how blood sugar works, because I think it's oftentimes very misunderstood. I think people think about it in a very linear fashion, it's just one way. But there are multiple ways the body can impact blood sugar, insulin release, etc.

Melanie Avalon: I actually learned about something recently that I'm shocked. I didn't know about earlier. I'm very shocked. I used to always think that I had reactive hypoglycemia. I don't know if it's necessarily the example she gave, but it's the example she gave, where if you eat something, and then your body releases too much insulin, and your blood sugar drops lower than it was before, and you get feelings of having low blood sugar. I always used to assume that's what was going on. Maybe it was. But actually, I didn't know there was something called idiopathic postprandial syndrome and that's actually where it feels like reactive hypoglycemia. It feels like you ate and your blood sugar dropped. But if you were to actually test your blood sugar, it would be high. What's so cool about the reason that-- Well, I don't know if it's cool, but the reason that's happening there, like, theories about it, but it's likely because the body's trying so hard to control the blood sugar level that you get all of those hormonal feelings of anxiety, or shakiness, or fatigue, or adrenaline, and it's your body trying to control things rather than actually being low blood sugar. I'm just surprised. I didn't know that until a month ago. 

Cynthia Thurlow: Well, the word idiopathic really just means we don't understand why this happens. It'd really be a diagnosis of exclusion when they've rolled out everything else. But I think when we talk about reactive hypoglycemia, those are typically the people they get sweaty, they get diaphoretic, they get dizzy, they feel nauseous, they can get pretty symptomatic. And I think many years ago, when I was in school, we used to think of that as being very benign, but I look at it as it's sometimes that beginning stages of identifying that your cells are not well adapted to insulin.

Melanie Avalon: I just find it so interesting that you can have that exact experience and not have low blood sugar and that's like a thing. Got to love the word, 'idiopathic' for-- 

Cynthia Thurlow: Idiopathic means we don't understand why. That's basically what that means. People were like, "Oh, we'd--" [crosstalk] 

Melanie Avalon: But it makes it sound fancy. 

Cynthia Thurlow: Exactly. And I'm like, "It's really not." It means we don't understand why this happens and you're in this bucket.

Melanie Avalon: Love it. Love it, love it. Shall we answer a question from Catherine? 

Cynthia Thurlow: Absolutely. 

Melanie Avalon: This is from Catherine and the subject is: "IF weight and fat gain." And Catherine says, "Hi, I've read so many books and products you have recommended. I love this lifestyle and I love your books and podcasts. I've been wanting to write for a while and I kept telling myself, "I just needed to figure it out on my own." But as time goes by, my weight and fat keep creeping up, I thought I better seek your wise counsel. I began intermittent daily clean fasting, the first week of August 2019. I began my IF journey to maintain a weight loss of over one hundred pounds, but I've gained 20 pounds since starting IF. I'm 57 and 5'6.5". I walked 2.5 miles daily. I play pickleball." What is pickleball?

Cynthia Thurlow: I don't know. I think it's like a smaller bat.

Melanie Avalon: Pickleball according to Google is an indoor or outdoor racket paddle sport like you said. Like tennis with little, small bats. 

Cynthia Thurlow: [laughs] She's probably English. 

Melanie Avalon: Oh, yes. Okay. She plays pickleball or does it work out a few times a week. "Before if I was counting macros and every calorie I consumed or burnt daily to not regain. And I was successfully maintaining and still losing, but it was not fun at all, and I did not feel well. After dieting off and on, my entire adult life, I'm being overweight my entire adult life, I finally lost weight with the ideal protein diet. I think I heard Gin's recommendation to continue your current way of eating and add IF, but I did not follow that advice. Also, although I know it is not what you two would recommend, I just think I went overboard with eating what I had been denying for so long. I know that is not advised, but after limiting carbs or fat for so long, I just went for it. I love the simplicity of delaying and freedom of not denying but fear I have taken it too far." 

She said, "I usually fast for 19 to 20 hours and have a two to five-hour eating window. Typically, I have a shorter eating window on weekdays one to two hours and sometimes will lengthen it on weekends to three to five hours. I eat a healthy, typically paleo supper meal each day. I think my problem might be too much of a snack before and after that healthy meal. I started out between 125 to 130 pounds in August wearing a size four to six with very little fat on my bones and coming from a very restricted diet. I now weight 145 and I can see fat on my body. I can still wear the same jeans, but not all my clothes from 20 pounds ago. I feel great, I feel healthy, I look healthier. My hair is glowing. But I really liked the number 125 and I really liked seeing myself skinnier. if I'm completely honest, I looked pretty gone at 125. I do look healthier now. I hear all the stories of weight loss and feel, I should have at least been able to maintain my weight with IF. 

Honestly, I could probably be happy with 135. I do not want to continue gaining weight. I'm wondering if I need to deny sugar and chocolate indefinitely as it is probably a trigger for me. Should I start counting the calories of my snack or dessert? Is there anything you can recommend for me? I will not go back to dieting. I am IF for life. Thank you so much for your books and podcasts. I have learned so much from you. I so look forward to your direction and thank you in advance."

Cynthia Thurlow: Well, Catherine, thank you for your question and congratulations on the progress you've made. A lot of what I hear in this question is, you really like one number, but you feel healthier, better, your hair looks healthier at a different weight. And herein lies a lot of the problem in the weight loss industry. We get very fixated on numbers. And I'm speaking to you as a clinician that at a minimum, I would get some basic lab worked on, so that you can see where your triglycerides are, and your HDL, and look at your fasting insulin, your glucose, your A1C really get a sense of your thyroid and sex hormones to see really where you are. 125 pounds is pretty thin for 5'7" female. 

And you yourself mentioned that you've looked gaunt. From my perspective, it's really stepping back and objectively saying, what is driving the focus on that number? Because it sounds to me that you actually feel better at a different number. I would say, the other thing and this is a resounding theme for me is that if you're only eating within a very short window, are you eating enough food? Because your body could be perceiving that you are not enough food that you're starving and it's going to hold on to every single calorie and morsel of food. Really making sure that your meals are structured focused on protein, as well as non-starchy vegetables. You may be craving chocolate and sweets, because you're not getting enough food. And so, I really think you need to objectively and honestly look at, are you eating enough food in your feeding window? You may not be. And checking in with your primary care provider, your internist, your GYN to get some baseline labs, I think is a really important first step. And then also giving yourself grace. 

There are so much focus in our society on weight numbers, instead of focusing on health and what allows you to go out and play your sports, and to walk, and doing all the things you're doing it. It doesn't sound like for you that you want to track macros and that's okay. I would really try to be deliberate about getting enough protein in your diet and we usually focus in on a hundred grams a day. Hundred grams per pound of ideal body weight. And really focused in on healthy fats and non-starchy vegetables and also, that mindset shift. I know, both Melanie and I have interviewed Dr. Glenn talking a lot about our relationship with food. I think that those interviews would be super helpful to hear his perspective and he talks about the inner pig, not that we're a pig, but the inner pig in our brain that's telling us to behave a certain way. 

And make sure you're getting enough sleep. And make sure that you have great relationships with loved ones. And making sure that you feel satisfied in your personal life, I think is certainly a very, very important part of this. But the concerns that come up for me are, are you eating enough? Having this fixation on a number that may not be a healthy number for you to be at. I have had so many female patients that will say, "I want to weigh what I waited 18" and yet, this is 20, 30 years later, and it's woefully not realistic for them to weigh. What they did at 18 years old, when they probably weren't nourishing themselves or probably not getting enough sleep, etc. Melanie, what are your thoughts?

Melanie Avalon: First of all, I love all of that that you said, and I agree. I want to clear up one little thing. She says that she had heard Gin's recommendations about continuing your current way of eating and adding IF, so not changing the way you're eating. What's interesting about Catherine situation is, so, Gin's perspective on that it's normally not Catherine situation. It's normally people who are coming from a standard American diet and Gin says, "Start IF rather than cleaning up your diet at the same time." Whereas Catherine situation, she was on a really restrictive diet. And so, she did "change" when she started IF, because instead of staying on the restrictive diet, she started eating much more freely, which the two clarifications there is that I think-- I don't want to put words in Gin's mouth, but I think Gin would be more on board with that concept, actually. 

And then, two, I think people can do it either way, but I actually don't have a problem with people starting IF and making dietary changes at the same time. I actually think it's really great. I think if people want to like start, especially if coming from a standard American diet and they want to make a healthy, whole foods type choices at the same time as they start IF, I think that's great. I just wanted to clarify on that. I think everything that Cynthia said that that lower weights that Catherine was at might not necessarily be a sustainable weight, if you want to maintain certain health and energy related goals at the same time. So, really what you have to ask yourself, because I'm goal-- Am I goal agnostic? I'm goal agnostic for other people. I personally believe that our goal should be health and wellness and energy and vitality. But also, I believe that people can have whatever goals they want. It's their body. You can pursue what you want to have in your body. And for some people, if they want to be a thinner weight that requires dietary restriction, you can do that. It might not be a healthy approach to life and it might be hard to maintain. Because Catherine experienced that. She was calorie counting, she was macro counting, she wasn't enjoying her life, she didn't feel as good. So, that might just be what is required to have been at that weight. And so, you just have to ask yourself, "Is that what you want?" 

And what I am wondering, though is, I think there actually is a lot of room. Stepping back, I know you did actually, physically gain weight because you say with an exclamation point, how you can see the fat on your body. But I also do wonder if making this change from having been calorie restricted and being in a calorie deficit to sounds like you're just going and eating all the things. I wonder if there's a level of inflammation that came along with that style of eating, so there might be a happy medium. This is just an idea. But there might be a happy medium that doesn't actually require calorie counting, it doesn't require macro counting, it doesn't require restriction, where you're just cleaning up those food choices that you are making. I think that might be a place to start rather than trying to go the restriction route. 

Cynthia was talking about the importance of a high protein diet and the green vegetables. And so, maybe having a mindset shift, where we What are the healthiest foods you can put in your body in your eating window, what is the healthiest way you can approach your snack and your dessert? If you have them, can you possibly have other versions? Can you not have the snack or can you have other versions of the dessert and snack that might be more fulfilling or healthier for your body? I would just maybe approach it more from a health mindset with a few choices rather than a restriction mindset. Because I think it's completely 100% possible for you to actually have all the goals, which would be the energy, and the skin, and feeling amazing in your body from that perspective, and also, being at a weight that makes you happy, and it doesn't necessarily require restriction. Any thoughts to that?

Cynthia Thurlow: I do fervently believe a lot of it's a reframe. So, really thinking about your relationship, not only with your body, but with food as well can be very, very helpful, for sure. 

Melanie Avalon: Also, I love that you brought up Glenn Livingston. He is honestly one of my favorite people on the planet. His book, again, it is called Never Binge Again, which is a little bit of a misleading title, because it's not just for people who are struggling with binge eating disorder, but it's really wonderful for that mindset shift and reframing how you are seeing food, your cravings, your wants, your desires. I find it very helpful.

Cynthia Thurlow: That's a great book. Actually, I think twice this week already, I suggested that episode to women in different groups. 

Melanie Avalon: I love that. I love that. 

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Melanie Avalon: All right, shall we go on to our next question? 

Cynthia Thurlow: Absolutely. 

Melanie Avalon: I'm excited for this question, because it's a Cynthia question. This comes from Lydia and the subject is: "IF and palpitations." And Lydia says, "Hello, I'm Lydia. And recently, July 11th to be exact began doing intermittent fasting. I purchased Delay, Don't Deny and listen to the podcast regularly, as well as join the Facebook groups. Well, I soon began to have heart palpitations and I have read that maybe I was dehydrated. I upped my water intake, I added Himalayan salt occasionally, but I was really having a bad time with the palpitations. They especially occurred when I lay down for whatever reason. I'll be seeing a cardiologist soon after getting an electrocardiogram and after wearing a Holter monitor for 48 hours. But after I stopped doing the clean fasting and I stopped longer fast, the palpitations are mostly gone. So, is it possibly dehydration after all? Have you heard of others having this issue? I was so happy to have lost 10 pounds by August 14th. But now, I'm slowly gaining back since I haven't been clean fasting. By the way, my starting weight was 167 and I'm about 5'6". Now, I'm back to 161 after getting to 157 by August 14th." Thank you, Lydia.

Cynthia Thurlow: Well, Lydia, this is my wheelhouse. The listeners know that my whole background as an NP was in ER Med and cardiology. And the one thing that I know a lot about are palpitations, ones that are benign, but annoying and dehydration. And I would absolutely agree that if you are going too fast, you need electrolytes. And yes, Himalayan sea salt is great, if you're salting your meals. But you actually need a more comprehensive product and that one that is going to provide potassium, and magnesium, and sodium, and chloride. And so, anytime anyone is fasting, especially in summer, it's really, really important that you're replacing those electrolytes. And it more than likely, I would imagine that the palpitations are probably precipitated by low magnesium. And this is more often than not the electrolyte in particular that I see most people are not keeping optimal levels of. And really the blood tests that you want to ask for when you see the cardiologist and any cardiologists will order this as a red blood cell magnesium. It's much more accurate. But also doing a comprehensive metabolic panel. It sounds like they're doing quite a big workup if they're doing a Holter as well as an EKG. 

If you're seeing an association of fasting correlated with the palpitations and now that you are stopped the clean fasting and stop longer fast, and the palpitations are almost gone, I think, oftentimes, we'll say correlation is not causation, but this is clearly a relationship that sounds it is directly related to the dehydration. You're probably experiencing by not replacing the electrolytes in a fasted state. One thing I teach people when they're fasting for the first time is that electrolytes are critically important, especially, if perhaps at that time, you lowered your carbohydrate intake. We know when you tend to be lower carb, you have release of glycogen, which is stored sugar and you'll actually urinate out more electrolytes including sodium. And so, it's very, very important that you're replacing that. And there's lots of clean options. I have a product called Simply Hydration. There's LMNT and many other options that are out there. 

The other thing is you mentioned that your weight fluctuated from 161 to 157 pounds. It is not at all uncommon depending on what we're eating and drinking that our weight could fluctuate by three to five pounds. And so, I don't know what age you are, but that can happen around our menstrual cycles, it could happen if we had a lot more carbohydrates. And so, I wouldn't get too concerned about four pounds. It's always over the period of time. There's a colleague of mine that always talks about there's the Hell No Way. When you get to a point where you're like, "Okay, this is five pounds over where I generally am average wise and then it's time to ratchet in on the cleaner eating." I would absolutely follow up with your cardiologist. They sound like they're doing a really nice job. I would focus on comprehensive electrolyte replacement and especially, in a fasted state. More hydration, more electrolytes, and recognizing that there is that interrelationship. And it's probably related to low magnesium and I'm actually setting Melanie up, so that she can talk about magnesium. 

Melanie Avalon: I love that. Well, first of all, for listeners who might not be familiar, Cynthia, what is your background in cardiology?

Cynthia Thurlow: Well, it's interesting. I did general cardiology, but then when I transitioned into to predominantly doing office setting, I worked with a lot of our electrophysiologist, who are specialized cardiologists that do defibrillator, and pacemakers, and deal with arrhythmias. When I tell you that I know magnesium backwards and forwards, more often than not even in the benign arrhythmias, it was magnesium that was precipitating episodes. And more often than not in the lethal arrhythmias, things that originate from the ventricles, which are the bottom chambers of the heart. It was magnesium that was driving some of those symptoms. When I tell you that I know magnesium well, I've gotten very creative over the years with magnesium replacement. We could certainly if Melanie, if you want to we can talk about other ways to replace magnesium either with transdermal applications, or soaking our legs, or taking products by mouth. All can be very, very helpful when getting our magnesium levels back up.

Melanie Avalon: Yes. Well, first of all, I just love that you have that background and that knowledge. I will put in a plug for LMNT. Cynthia mentioned them. But we do have an offer for them. There are full-spectrum electrolyte supplements. So, not just magnesium. It's magnesium, potassium.

Cynthia Thurlow: Sodium chloride.

Melanie Avalon: Dah. Sodium. So, you can go to drinklmnt.com/ifpodcast and we have an offer there. I believe the offer right now should be to get free electrolytes at that link. Definitely check that out. And then, yes, it is so, so exciting that Cynthia is on board and on the same page as me about the importance of magnesium. So many people are deficient in magnesium. I'm actually not for taking all the vitamins all the time. I think it should be very nuanced and specific to the individual. And that, when possible, we should try to get our nutrients from food. That said, it's really hard to get adequate magnesium levels today. Our soils are depleted. It's been estimated that in the past one hundred years, the soil levels of the magnesium have gone down by 90%, which is crazy. And then on top of that, that's just the actual levels of magnesium. That doesn't account for the fact that pesticides and glyphosate in the soil actually chelate magnesium. So, a lot of that magnesium isn't even available to the body to be used in its proper form. And then on top of that, it is potentially toxic, because it's attached to a pesticide. 

The fact that most people are deficient is no surprise. And so, like Cynthia said, there's lots of ways that you can boost and raise magnesium levels. I recently released my Magnesium 8 by AvalonX and I formulated it to honestly be the best magnesium on the market. I promise, it is the best, because I wanted to make the best. It is eight forms of magnesium and their most bioavailable forms. But it comes with methylated B6 to help with absorption, not the non-methylated form, which is often used in supplements. And then it has manganese, because magnesium can often displace manganese. And then it's in a glass bottle, because I am not about plastics leaching into our bodies in the environment, which by the way, Cynthia, I just booked a guest. I'm really excited about. Matt Simon, he's the head editor at WIRED and he has a book coming out in 2022. He has some other books, but his book coming out in 2022 is about the effects of microplastics and the environment. I'm so excited, because I think that's a really big problem. So, I'm really excited to read this book and learn about that. 

Oh, and this was crazy. One of my best friends from college ever worked at WIRED. I emailed him. I was like, "I don't know how many people are on staff at WIRED, but do you know my friend?" And he's like, "Oh, yeah, we sit next to each other in the office." It's such a small world. So, all that to say, you can get my Magnesium 8, that is at avalonx.us. The coupon code, MELANIEAVALON will get you 10% off. I think we will have launched subscriptions by the time this comes out. If you get a subscription for that, you can get actually 15% off. The other ways of getting magnesium would be like transdermal.

Cynthia Thurlow: And I like a product called Ancient Minerals that we will link up. You can spray that into two cupped hands and rub it on your, I usually say, trunk. Like upper arms, legs, trunk. And if your skin tends to be sensitive, you want to pick the sensitive skin formulation. But you can leave that on for 20 minutes and then rinse off. That's super efficacious.

Melanie Avalon: So good resources there. Hopefully, that helps, Lydia. Do we have time for one more question?

Cynthia Thurlow: Sure. Our next question is from Sarah. Subject is: "positive side effects." "I've been doing IF since the first of the year as an experiment just to see how it worked for me. Your podcast has been a valuable resource for me and I'm grateful for all your tips. I don't need to lose any weight or gain energy, but I was tired of constantly thinking about when and what I was eating to get maximum nutrition benefits. I felt I was either eating or preparing to eat all the time. Needless to say, IF has changed that with a shorter afternoon window usually 3 PM to 8 PM. I have always eaten a pescatarian diet with a balance of nutrients. I do enjoy at least a small, processed food snack a day like Chex Mix or Cheez-It and I've not changed my diet at all. 

I am so much less stressed about food, and I think I can finally achieve the rest and digest state. One of the positive side effects that I've noticed in myself that I don't think I have heard you discuss is the change to my bowel movements and the decrease in gas. I often had gas in the evenings and carried Gas-X in my purse at all times. I have not needed to take it on the last two months. Also, sorry, if this is TMI, but my bowel movements were previously very soft. Since intermittent fasting, I noticed my bowel movements are now more solid and easier to clean. Just wondering, if this is truly a result of intermittent fasting and why the change. Thanks, and keep up the good work." Casey.

Melanie Avalon: Thank you so much for your question and we're very excited for you that you've experienced so many wonderful effects with intermittent fasting. Earlier, Cynthia was using the phrase "correlation, not causation and how it's hard to know." But I would say, it's very likely that if the only thing you perceived as having changed was IF and then you had this substantial change in your bowel movements, then it's probably related to IF or changes from IF that led to this. I mean, it's a good problem to have. So, I'm happy that we're not trying to find the problem and solve it. But there's so many different things that could be going on for why you might experience better bowel movements. By not eating constantly, it gives our GI tract. It allows for the natural peristalsis of the intestine, and it allows things to be moving. So, it can create a better synchronicity and rhythm to your system, where your digestive system has time to rest to clean out with those cleansing waves and not have things build up that are creating gas. It also might be--

You talked about how now finally when you're eating, you feel you're in the rest and digest state, so the parasympathetic state. That is so, so important for properly digesting our food, for creating stomach acid to digest our food, enzymes. The fact that you are just likely digesting your food better, it could be a huge reason that you're not having gas anymore, you're having better, more well-formed bowel movements. It's just helping your body process food better. And then the effects on the gut microbiome, so, there's a lot of effects that could be happening there. It's possible that this change with the fasting is actually supporting a more favorable gut population. There have been studies on fasting finding favorable effects on the gut microbiome. So, it's possible that you've had changes there. Cynthia, thoughts?

Cynthia Thurlow: I would echo your sentiments. And I think a lot about the migrating motor complex. And so, in our digestive system, we really do need four to five hours between meals to allow this sweet sweeper of the GI tract to be able to do its magic. And there's so much good research talking about the gut microbiome and the benefits of eating less frequently. And is it any surprise that your digestive processes is out now in a position, where it can properly package up and get rid of waste? And so, not at all surprised to hear that your bowel movements are much more solid. We use that Bristol stool scale. Melanie, have you seen that before?

Melanie Avalon: Have I? You're talking to like the-- [laughs] 

Cynthia Thurlow: We aim for the for. That's what we're working towards. And so, it just shows that your stool is-- there's enough time for your body to break down absorb nutrients, get rid of what doesn't belong, you're not dehydrated. I think our stool is really one of many indicators of our health. So, bravo and excited that you've had seen so many benefits so quickly.

Melanie Avalon: I probably shouldn't share this. I should probably envision thousands of people listening before I say this. It's funny, because they'll do things. I don't know who 'they' is. You'll see things where people say, "Eat something really pigmented, so you can figure out how long your transit time is," like do a beat test or like a blueberry test. 

Cynthia Thurlow: We used to do corn.

Melanie Avalon: Okay, corn. And it's funny. Whenever I see that I'm like, "Wait, doesn't everybody always monitor that, like, monitoring that 24/7?"

Cynthia Thurlow: You're hilarious. No, it's interesting. There's a program that I teach in the fall called RESTART. I think it's week two. I actually have them bring corn to class, and they ingest two tablespoons of corn, and then they let me know how long it is before they see it in their stool.

Melanie Avalon: I had an intake form with a doctor and he's like, "We're going to do this." I was like, "I do that every day. I can already tell you that." 

Cynthia Thurlow: You are like, I'm an ideal patient.

Melanie Avalon: I already know the answer to that question. All right. Well, this has been absolutely wonderful. A few things for listeners before we go. We will put links to everything that we talked about in the show notes. Those will be at ifpodcast.com/episode282. A reminder to everybody to definitely go to shieldyourbody.com/rsd for Radiation Safety Day. That's where you can learn the two key rules to help protect yourself from EMF exposure for free and get entered to win a EMF blocking bed canopy worth $2,000, as well as a lot of other prizes. All for free. Lots of resources. That's shieldyourbody.com/rsd And again, the coupon code, MELANIEAVALON will get you 15% off, if you would like to purchase anything from Shield Your Body. 

And there will be a full transcript in the show notes. You can definitely check that out. And then lastly, if you would like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. And you can follow us on Instagram. We are @ifpodcast. I am @melanieavalon, and Cynthia is @cynthia_thurlow_. Well, this has been absolutely wonderful. Cynthia and I will talk to you next week. 

Cynthia Thurlow: Sounds good. 

Melanie Avalon: Bye. 

Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team. Administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

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If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Aug 21

Episode 279: Organic Wines, Blood Ketones, Urine pH, Fasting Insulin, Continuous Glucose Monitors, Appetite Hormones, Lean Protein, ADF, And More!

Intermittent Fasting

Welcome to Episode 279 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

LMNT: For Fasting Or Low-Carb Diets Electrolytes Are Key For Relieving Hunger, Cramps, Headaches, Tiredness, And Dizziness. With No Sugar, Artificial Ingredients, Coloring, And Only 2 Grams Of Carbs Per Packet, Try LMNT For Complete And Total Hydration. For A Limited Time Go To drinklmnt.com/ifpodcast To Get A FREE Sample Pack With Any Purchase!

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To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

Visit IFpodcast.com/episode279 For FULL Shownotes, And IFPodcast.com/StuffWeLike For All The Stuff We Like!

LMNT: For A Limited Time Go To drinklmnt.com/ifpodcast To Get A FREE Sample Pack With Any Purchase! Learn All About Electrolytes In Episode 237 - Our Interview With Robb Wolf!

DRY FARM WINES: Natural, Organic, Low Alcohol, Low Sugar Wines, Paleo And Keto Friendly! Go To dryfarmwines.com/ifpodcast To Get A Bottle For A Penny!

The Melanie Avalon Biohacking Podcast Episode #5 - Todd White

Episode 26: IF & Low Sugar/Alcohol/Toxin Wines For Health – Special Interview With Todd White Of Dry Farm Wines!

Listener Q&A: Doreen - My first inquiry

The Melanie Avalon Podcast Episode #70 - Kara Collier (Nutrisense)

Ep. 132 – Continuous Glucose Monitors: Why They’re Not Just for Diabetics Anymore with Kara Collier

NUTRISENSE: Get $30 Off A CGM At Nutrisense.Io/Ifpodcast With The Code IFPODCAST

JOOVV: For A Limited Time Go To joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount!

For A Limited Time Go To butcherbox.com/ifpodcast And Get Free BACON For LIFE Plus $100 Off Over 5 Boxes!

AVALONX MAGNESIUM 8Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist, And Use The Code Melanieavalon For 10% On Any Order At Avalonx.Us And MDlogichealth.Com!

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 279 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time and get ready for The Intermittent Fasting Podcast. 

Hi, friends, I'm about to tell you how you can get my favorite electrolytes for free. Yes, completely free. And the feedback we have received about LMNT electrolytes from our audience is overwhelming. You guys love LMNT and I'm so excited because our new offer allows new and returning customers to get free LMNT. And on top of that their super popular Grapefruit flavor is back. If you've been having issues with intermittent fasting, electrolytes may just be the thing that you need and/or have you heard of something called the keto flu? Here's the thing. The keto flu is not actually a condition. Keto flu just refers to a bundle of symptoms, headaches, fatigue, muscle cramps, and insomnia that people experience in the early stages of keto dieting. Here's what's going on. When you eat a low-carb diet, your insulin levels drop. Low insulin in turn lowers the production of the hormone aldosterone. Now, aldosterone is made in the kidneys and it helps you retain sodium. So, low aldosterone on a keto diet makes you lose sodium at a rapid rate and even if you are consciously consuming electrolytes, you might not be getting enough. In particular, you need electrolytes, especially sodium and potassium in order for nerve impulses to properly fire. Electrolytes can easily be depleted while intermittent fasting.

Robb Wolf, who as you guys know is my hero in the holistic health world worked with the guys at Keto Gains to get the exact formulation for electrolyte supplements to formulate LMNT Recharge, so you can maintain ketosis and feel your best. LMNT Recharge has no sugar, no coloring, no artificial ingredients, no junk. They're used by three Navy SEALs teams, they are the official hydration partner to Team USA weightlifting, they're used by multiple NFL teams, and so much more. We have an incredible offer just for our listeners. You can get a free LMNT sample pack that includes all eight flavors. Citrus, Watermelon, Orange, Raspberry, Mango Chili, Lemon Habanero, Chocolate, and Raw Unflavored. And the Raw Unflavored, by the way is clean fast friendly. You can try them all completely free when you make a purchase at our link, drinklmnt.com/ifpodcast. You can get this offer as a first time and as a returning LMNT customer. I know there are a lot of returning LMNT customers. The feedback I hear from you guys, "loving LMNT" is amazing. LMNT offers no questions asked about refunds on all orders. You won't even have to send it back. And this offer is exclusively available only through VIP LMNT partners. You won't find this offer publicly anywhere else. So, again, the link is drinklmnt.com/ifpodcast. And we'll put all this information in the show notes.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting. It's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup maybe playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies, when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years. 

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later, maybe half of that lead has left your bones. On top of that there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They are counter time for antiaging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check on my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out. And you can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you're thinking of making Clean Beauty and Safe Skincare, a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like the Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now, back to the show.

Melanie Avalon: Hi, everybody and welcome. This is Episode number 279 of The Intermittent Fasting Podcast. I'm Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, there. 

Melanie Avalon: And Cynthia, I have a fun topic that we can talk about briefly if you would like. You already know this, because I asked your advice about it yesterday. For listeners, yesterday, I went to a gender reveal party for one of my friends and it was an evening event. And I knew there was drinks and wine. I actually asked her ahead of time. I was asking Cynthia, I was like, “Is it okay, if I bring my own organic wine to this pregnancy related event, if there's already drinks?” You said that you thought that would be appropriate. So, I did. But I did not bring Dry Farm Wines and I regret that decision. My [laughs] Oura Ring this morning, it's crazy how much it knows when you're drinking wine you shouldn't be drinking and maybe too much of it and not sleeping well. But what's really interesting is, my sleep was great, just my readiness score is awful. I bring it up because I think I need these moments to remember why I only drink Dry Farm Wines and you recently interviewed Todd White.

Cynthia Thurlow: I did. First of all, it was really interesting to prep for that discussion. And then when I got off the phone, I'm sorry, I got off the recording, I was saying to my husband it has been very common for me over the last several years to just send team members, family members subscriptions to Dry Farm Wines and how easy that has been. And I said, “I didn't fully appreciate and realize the differences between conventional winemaking here in the United States versus natural practices.” Certainly, from this point going forward, I really understand and appreciate the chemical and exposure load that you get from conventional wine, which I was really-- 

Let me be very clear. I think I'm a pretty well-educated person about processed food industry and nutrient dense Whole Foods, but I hadn't really considered the net impact of conventional winemaking here in the United States. And so, that was a really enlightening podcast. I can imagine how you felt differently. I think, if I recall from our conversations last few days, you were planning on bringing an organic option or organic options with you. So, even with the organic wines, you still felt poorly. I wonder if it was the alcohol content.

Melanie Avalon: I was telling you this already. But basically, at home, I only drink Dry Farm Wines. And for listeners that are not familiar, they're not a wine producer. They're like an investigator and a distributor. They go all throughout Europe, only Europe, because Todd says that, “None of the US wines meet their standard.” And I think that's in part, because of just how saturated the US environment is in pesticides, even organic like plots of land. The wineries from there, they did a test. I don't know. Did he bring up the test that they did a while ago and they tested all these different wines in California, including organic ones and every single one tested for pesticides, which is just crazy. They find the wines that are low in sugar, so less than I think one gram, and then low alcohol, so 12.5% or less, and then they test them for heavy metals, pesticides, mold. I noticed such a difference drinking them. 

But what I did for this party was, I do have a collection of wines that are not Dry Farm Wines that are organic that I just have from over the years that I'm not going to drink by myself at my apartment, because I really just drink the Dry Farm Wines. So, I bring them to events like this. But now in retrospect, I'm like, “I should have just brought Dry Farm Wines.” Then again, I did have a lot.

Cynthia Thurlow: Well, maybe it was dose dependent. Meaning, perhaps, if you had had one glass of the organic wine, maybe you were fine. Maybe it was two glasses might have been just enough to disrupt your sleep quality.

Melanie Avalon: Yeah, probably.

Cynthia Thurlow: That's my guess. I always say, “Maybe it's dosage dependent.” I say that to patients like, “Maybe it's the quantity and not so much per se that it was not Dry Farm Wines.” But the one thing that I think I was really surprised by when I spoke with Todd was the differences in alcohol content. Conventional wines can be greater than 15% alcohol versus six to 12.5 is-- Most of the Dry Farm Wines really run and they are, as you mentioned, lower sugar. And so, we know that that impacts us on pretty significant profound ways. So, but did you have fun? 

Melanie Avalon: Yes, I had so much fun. It was fabulous. And even that said, I'm still good. This is not my college days or anything. No, I did. I have not been to a gender reveal party before. 

Cynthia Thurlow: Neither have I. But that also says generationally where I am. My oldest will be 17 next week. And so, I'm just at a different-- When I was pregnant, people chose to either find out at 20 weeks what gender child they were having or not. And so, now, people can find out a whole lot earlier and it seems to be something that's very trendy and fun. And I think there's always opportunities to celebrate babies. It's such a fun exciting time.

Melanie Avalon: Yeah, I agree. It's funny. They wanted you to wear blue or pink based on what you thought it would be. I only wear black dresses. I wear a black dress, but then I wore sparkly shoes that were blue and pink.

Cynthia Thurlow: I like that. You're in a neutral zone. 

Melanie Avalon: Yep. [chuckles] So, yeah. But for listeners, to learn more about Dry Farm Wines, which I'm just so obsessed with, our link will get you a bottle for a penny. So, go to dryfarmwines/ifpodcast and that's where you can get that offer. And then, Cynthia when do you air that episode with Todd?

Cynthia Thurlow: Actually, next Saturday. So, it will be August 13th that episode will air.

Melanie Avalon: Okay. Awesome. So, that'll actually be aired by the time this comes out. We'll put a link to that episode. We'll also put a link to the episode that I did with Todd way back in the day. He was one of my first episodes on The Biohacking Podcast. Well, I'll also put an episode we've had him on the show. So, I'll put a link to that as well.

Cynthia Thurlow: Yeah, he's a great guy. It's interesting, because I'm married to a Todd. And my Todd really likes the red selections from Dry Farm Wines. And it's interesting. We recently placed an order and he always feels there's too much white wine in our house. I think because maybe our guests drink the red wine. This last order that we've received, he has been very happy with.

Melanie Avalon: Well, so, that's something because I know that you personally you don't drink at all, right?

Cynthia Thurlow: I don't. It's the only thing that really erodes my sleep. By this, for everyone who's listening, if you're not yet in the perimenopause range, it is the only thing that gives me hot flashes. So, I just don't drink for that reason because hot flashes, especially when you're trying to fall asleep are not fun. But yeah, that was a large decision why I stopped drinking much of anything. I didn't drink much to begin with. I've always been more of a very, very light drinker.

Melanie Avalon: With me having drank the Dry Farm Wines over the trajectory of there, because I probably started, I don't know, when they were founded.

Cynthia Thurlow: Seven years ago, I think, Todd was saying.

Melanie Avalon: Okay. I started drinking them in probably 2014 or 2015. I probably started drinking them right at the beginning, like 2015. They have not improved, but they have improved. You were talking about the red wine. In the beginning, most of the reds all were very, very light. They didn't have many more robust reds, because I think it's harder for them to find those that fit all their criteria. But they have evolved. That's a good word. They've evolved so much in the red wines that they source and some of their wines are just delicious.

Cynthia Thurlow: Awesome. You can drink them with a good conscience.

Melanie Avalon: Oh, yes. And now, I think I need these nights every now and then, like, last night to further appreciate why I only drink Dry Farm Wines normally. So, before we jump into questions, Cynthia, would you like to tell listeners one more time about the giveaway that you are doing?

Cynthia Thurlow: Yeah. So, this is the last week of the giveaway. And all we're asking you to do is, if you've purchased my book, Intermittent Fasting Transformation, please leave a review, screenshot the review, send it to questions@ifpodcast.com, and you will be eligible for an entry. You have to live in the continental United States and it's a grouping of some of my favorite products and designs for health, and a few other wonderful retailers that I work very closely with as a thank you. We'll pick one winner. This is the last week of the giveaway. So, please make sure you get your entries in and we will look forward to randomly selecting a winner.

Melanie Avalon: And I will just say, so, I know a lot of you guys have Cynthia's book, because we get feedback. I see it in the groups. But we haven't had that many entries and I'm just saying that to say you have a good chance of winning. So, if you have the book-- [crosstalk]

Cynthia Thurlow: The odds are in your favor. [laughs] 

Melanie Avalon: Yeah. I always like to emphasize this because I think giveaways where people think, “Oh, there's so many people entering. I have no chance of winning.” But a lot of people will think that and [laughs] you do have a good chance of winning. And it also just really helps support Cynthia's wonderful book and we'd be so appreciative. So, definitely, definitely do that.

Cynthia Thurlow: And I don't think until I wrote a book that I realized how important those reviews are. So, please know that each and every review, I appreciate on a level beyond I can properly articulate. There are so many people that have really benefited from the book. I'm speaking from a place of gratitude and I would love to be able to send these goodies to one select individual. So, definitely get those entries into us.

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Melanie Avalon: Shall we jump into some questions for today? 

Cynthia Thurlow: Absolutely. 

Melanie Avalon: Okay. To start things off, this is a long question, but she has a fun story and then she has a lot of questions that we could just do rapid fire. This comes from Doreen and she wrote this to us back when Gin was on the show. So, she says, “Hi, Melanie, hi, Gin. Let me start off by saying, I absolutely love the podcast. I feel like you ladies have become my friends. You make me smile and laugh. You're smart. You're funny. Initially, I was listening in no specific order, but then I decided to listen every Monday to the new episodes and backtrack when I'm walking. Like many of your listeners, I have many questions that sometimes get answered before I need to submit them. I have several drafts with questions, but I can't prioritize which questions are the most important. Finally, after listening to Episode 159 with Dr. Anna Cabeca, I've been motivated to get some questions answered.” Really quick question for you, Cynthia. You are personal friends with Anna Cabeca, right?

Cynthia Thurlow: I am. She's wonderful.

Melanie Avalon: I think she's actually been on this show twice and on my Biohacking Podcast, maybe twice. Done a lot of interviews with her. I really like her work. Doreen says, “I am 54 years old, a certified personal trainer and yoga certified. I teach mainly hot yoga. It's very tough with a mask. I was heavy as a teenager at 5’2”, 184 pounds. My family celebrates everything with food. I'm Italian. At 16 with mom's help, I joined Weight Watchers and reached my goal in 1981. I'm still an active lifetime member and still track and weigh every few months. Diet and exercise and healthy eating, I've managed to stay within a six-to-eight-pound window with the exception of having my two children and some health issues. 

In 2015, I was diagnosed with cancer. I caught it early Stage 1. I did have some weight gain that crept up and I don't weigh myself now because of the way my clothing had stopped fitting. My first thought during the pandemic was panic. I'm going to gain weight without hot yoga. So, I took to the pavement, I started walking. During walks when my friends got back to work, I would binge listen to podcasts and I didn't gain the weight. Based on listening alone, I began adding IF into my routine and I feel fantastic. It's also helped with health issues, IBS, and GERD, et cetera. Melanie, I tried to get your book and Barnes & Noble had no copies. I was very excited to crack the book on our road trip from Long Island to Vermont. One of our favorite stops is for a place called the Creamery, which is a cute little country store. It's a constant on our trips to Vermont. I promise there's a reason for this story. 

I'm a shopaholic. So, while my husband and friends were getting the ice cream, I was power shopping around the store. I looked up and could not believe my eyes to my surprise staring me in the face was a copy of What When Wine with Melanie's beautiful face on the cover. I screamed. I was so excited. And of course, I bought it. It was divine intervention and favor. In Ludlow Vermont, they're carrying Melanie's books.” Okay, I just have to stop. This blows my mind. [laughs] I can't believe my book was in this random country store in Vermont. That is so random to me. Do you think these stores just order books and resell them, I guess?

Cynthia Thurlow: Well, I suspect maybe the owner or someone who's connected with the owner probably is a fan. 

Melanie Avalon: Wow. That would be so exciting to me, if I was in some random little country store and saw my book. I would not know what to do.

Cynthia Thurlow: You've made it, you know? You've saturated the rural country market.

Melanie Avalon: I know, I know. So, Doreen, thank you for sharing that story. That really made my day. Okay, so, now, she has rapid fire a lot of questions. Here we go. Number one, “With regard to ketones, pH levels in urine and all measures to determine clean fasting and eating. During the podcast with Dr. Cabeca, she discussed how important it is to test your urine for pH levels regarding ketones. I believed you said one could be burning ketones, even though you don't turn the strip's purple. There's also a question about blood sugar. I remember a discussion of different types of testing for blood sugar and blood fasting sugar. What's the difference? It would be very helpful, if you can clarify the importance of measuring pH levels in urine, ketone burning, and blood sugar, and which tests for IF purposes would be best, and where to get these kits and tests, and will they cost a fortune?” Okay, so, ketones, pH testing, blood sugar testing, would you like to talk a little bit about this, Cynthia?

Cynthia Thurlow: if you've been fasting and you're not new to fasting, then I would not anticipate that you would have urinary ketones present. It's much more accurate to actually test blood. But for the purposes of your constellation of questions, I would say that as a woman that it sounds you're in perimenopause/menopause that it'd be most valuable for you to know a fasting insulin and a fasting blood sugar. And a fasting insulin, you can get drawn with regular lab work. A Keto-Mojo is a good meter to use if you want to track your blood ketones. 

And then lastly, a fasting blood sugar with a glucometer or if you want to have a continuous glucose monitor, typically where I stay, I think it's important to know what your blood sugar is when you are in an unfed state. I think it's equally important to know what your blood sugar is in response to stress, nutrition, meals, exercise, etc. There's a lot of different variables to look at. I did a really great podcast. I know that Kara Collier has been on my podcast and also, Melanie's Biohacking Podcast at least once or twice. And that's a really fantastic resource and we will link that in the show notes.

Melanie Avalon: Do you put much weight into measuring the pH levels?

Cynthia Thurlow: No, I don't. I really don't. I think that there are a lot of metrics that we can measure. It doesn't necessarily mean that the information is all that valuable. Because if you're eating a nutrient dense Whole Foods diet, and you're not drinking excessively, and you're not eating a lot of processed carbohydrates, then ideally, and I have encountered a few functional medicine practices that will have their patients do urinary pH strips, but I think it gets expensive. And I've come to find that most of us like you and I, if you were to measure our urinary pH, it's probably more alkaline based on the types of foods that we eat. 

With that being said, when people are trying to budget for different types of home testing or monitoring, I think the most valuable one of all is really looking at fasting blood sugar or looking at a continuous glucose monitor. If someone is new to a lower carb ketogenic lifestyle, and they have not been in ketosis, and they're obese and overweight, then testing at least initially with urinary strips for ketones can be valuable. But if you have been in ketosis and you've been fasting for a long period of time, they're not going to show up in your urine. They are going to show up in your blood. I don't know if you have anything that you'd like to add to that. 

I think the big thing for me as a clinician is, there're a lot of metrics that we can measure. It doesn't mean we should measure everyone. We should decide based on our budget and our interests what is the greatest priority? I'm getting ready to bring the Keto-Mojo individuals on the podcast to talk more about testing ketones, because I get a lot of questions about it. But it really needs to be taken in the context of what are your risk factors, are you insulin sensitive, what are you trying to measure, what are the metrics you really want to look at and going from there?

Melanie Avalon: Are you interviewing Dorian? 

Cynthia Thurlow: I am, but not until February. Because right now, I'm booking into March. Yeah, which is I took time off around the book launch and now, we're back into eager beaver stage where we're booked out like six months.

Melanie Avalon: I was having flashbacks, because I connected with him right when they launched, I think as well and had him on this show. I think we had him on the show. He's British, right? Flashback to his-- He has the best accent. 

Cynthia Thurlow: And then his wife, I guess, is Emma?

Melanie Avalon: Is she British, as well?

Cynthia Thurlow: No, she's American, but they're really cute. They're cute little couple.

Melanie Avalon: Aww. Yeah, I'll just echo everything that you said just to really bring it into people's heads. With the ketone urine strips like Cynthia said, if you've been fasting for a while, if you've been even ketogenic for a while, you might not see that on your urine. I think they're most useful for somebody going from a standard American diet, not fasting to either ketogenic diet or fasting, because it shows when you start, just in general creating those ketones and the excess are spilling into the urine. But then the body becomes more efficient and you don't see that as much necessarily. So, there's real a time window when I would use those. 

And then for the blood sugar testing, yes, we are major, major fans of continuous glucose monitors. Those will really give you, because you'd asked me about the difference between the fasted blood sugar and then just the blood sugar. It's always blood sugar, but it's either fasted or postprandial, which means after a meal. And the only difference is just based on if you ate or not. And so, the levels might be different based on that. And so, continuous glucose monitor is so helpful or can be, because it shows you constantly how your blood sugar is reacting to fasting or eating short of that with just like a finger prick type situation. And this is what Cynthia said, as well. So, I think we're very aligned, 

I think if you had to choose-- once you try a continuous glucose monitor, you will realize just how much potentially your blood sugar can change even minute to minute. And I say that because you might do a finger prick and get a number that if you had tested 15 minutes earlier would be pretty different. It's much more clear picture with a continuous glucose monitor. If you don't like pricking yourself or you don't want to be pricking yourself all the time and you had to pick one time to prick yourself, I would probably go the Marty Kendall route, which is right before eating to see if you actually are in a lower blood sugar state ready for that meal. Because his data driven fasting is all about how people will open their eating window when they actually have high blood sugar. They think they need fuel, but they actually don't. It's very interesting. The link for that is nutrisense.io/ifpodcast and the coupon code, IFPODCAST will actually get you $30 off any subscription to a CGM program. So, definitely check that out. That can be a really helpful resource. 

Her next question, she says, “I'm in between ADF and one meal a day depending on what's happening in my life. Sometimes, I will do four straight days of 18:6, but then eat regularly on the weekend. I thought this protocol was good. Is it there a gray area and discussion about this topic? Do you agree that every day shouldn’t be a short eating window? Please clarify. I find myself contradicting my thoughts and I feel worried about opening my window too early.” I'm actually very curious your thoughts on this, Cynthia, because Gin would talk about this a lot, which was, in particular in regards to ADF, which is something that I personally have never done ADF. But she would often talk about the importance of if you're doing ADF not having a shorter eating window and not under eating on your fasting day. So, I'm really curious your thoughts on that and also on just if somebody was doing one meal a day, every day type situation?

Cynthia Thurlow: Well, I think listeners are probably not surprised to hear that I don't like ADF or OMAD as a sustained strategy for women or men for that matter, because there's just no way you're going to be able to get enough protein in one meal or this alternate day fasting. And there's a lot of what I believe to be emerging, both anecdotal and also research to suggest, unless someone's really stubbornly obese and is really trying to break through plateaus, most of us that are close to our ideal body weight, you start looking at the law of diminishing returns. And so, you just can't build enough muscle protein synthesis. I've spoken to Gabrielle Lyon about this extensively. I've spoken to Ted Naiman. And for listeners, those are both physicians in that space about how to stoke appropriate muscle-protein synthesis. 

I do like people varying their fasting and feeding windows. I think variety is very important, not just in our fasting windows, but also in the foods we choose to eat. I like a lot of variety. Same thing with exercise. However, especially when someone is trying to figure out what works best for them, it requires a degree of experimentation. What gives you plenty of energy, what supports sleep habits, what is allowing you to break through a plateau, do you need to be honest with yourself about the fact that you're not eating a particularly nutrient dense diet, and then you're attempting to do these prolonged fast to work through challenges that you're experiencing? And I'm starting to believe and starting to speak about this more that I am starting to see many women in particular that are doing this over-fasting, overtraining, over-restriction in an effort to lose weight. And we will obviously unpack more of this as the podcast goes on and I'll certainly be talking about it on my own podcast.

But in the context of this question, I don't like ADF and OMAD for a sustained strategy for women. It’s just impossible to get your protein in. And I'm very protein centric and I admit that. But when I look at the research and when I-- I'm a 51 year old woman. I just realized that I had a birthday last week. I have to remind myself, I mean, you're older. It requires a bit of effort to get sufficient amounts of protein into my diet. It is work that I'm happy to do. But I think in the context of answering this question that that's my prevailing thought process. How about you Melanie? 

Melanie Avalon:I keep rereading her question because I'm actually a little bit unclear now what she's actually doing. Because she says, she's in between ADF and one meal a day, but then she says, sometimes, she does four straight days of 18:6.

Cynthia Thurlow: I think she's doing a lot of variety. 

Melanie Avalon: 18:6, for example, would you consider that like a one meal a day, a six-hour eating window? I guess, it depends what they're actually eating during it. 

Cynthia Thurlow: Correct. I think a lot of people are just eating one big meal and maybe they're not hungry at the end of their six-hour feeding window. And that's the concern that I have. The more I talk to other metabolic health experts, the more I start thinking that we have to be less rigid and we need to really lean in like-- I've been experimenting this whole summer with having a wider feeding window. And, especially, because I've been lifting more, I've been more hungry, I've been breaking my fast earlier, I'm finding that I'm getting better results. And each one of us has different goals and different aspirations. But I think a certain degree of experimentation is important to not be so rigid with-- If something has been working, try something and try something new. We have a wider feeding window. And by wider, it's not my feeding window was 12 hours. It might be an eight-hour, a nine-hour or a 10-hour, so that I can have more meals with my family.

Melanie Avalon: Okay, yeah, I love that. I feel we always say that it's individual and you have to find what works for you, which feels like a cop out answer. But it's so, so true, because people are just so different. 

Cynthia Thurlow: Bio individuality rules. 

Melanie Avalon: Yes. Because me, for example, I do a shorter eating window. Yeah, I was thinking about this with you're talking about how you're struggling to get in enough protein and so many people say that to us. We get so many questions about that. And it's just interesting to me, because it's so easy for me. [laughs] I just eat so much protein.

Cynthia Thurlow: But I think my appetite was different at 30 than it is at 51, because I've tried to reflect on that like, “How much more food did I eat when I was younger?” There was definitely a point in my early 40s that I felt my appetite change significantly. A lot of my patients, and clients, and friends, we'll talk about this openly. We're like, “Oh, yeah, we don't eat nearly as much food.” I think that is a biologic drive. If you talk to someone who's 70, they don't have the appetite they had at 20. It's because ideally, we should not be in an anabolic growth phase at that stage of our lives. Whereas, I have teenage boys and they're very much in this anabolic building stage and they're healthy, they're lean, they're muscular. It's a very different phase of life. And so, I think so much of it's dependent on where we are in time and space. It is a concerted effort. 

For me, to hit my protein macros every day and it's not that I don't like to eat. Protein will fill me up and then I'm full and I'm like, “Okay, now, four or five hours later, I ate another protein bolus.” And that's how I navigate. I eat a lot of eggs. Someone asked me the other day, “How do you get that much protein?” I was like, “I eat a lot of eggs.” Because I can eat a good amount of eggs and I don't feel nearly as full as I would if I ate a piece of steak. But I always like to shake things up.

Melanie Avalon: I'm super curious. When you did have a higher appetite, when you were in your 20s and 30s, did you ever do an approach like me where-- Literally, the foundation of my meals is lean protein., I don't really add-- It's hard to describe, but I basically just eat tons and tons of chicken, fish, scallops. That's the volume of my meat. That's the base of it. Did you ever do that approach or was it always in the context of adding some fats, some oils? I'm just wondering how much that affects how much you actually eat.

Cynthia Thurlow: Well, you have to remember that when I was 30, I was in a hospital working all day long. And I became a parent when I was 34, a second child at 36. And so, I would never have been able to manage the kind of eating schedule that I have now around those responsibilities, because you're lucky if you can eat at all [laughs] when you're working in a hospital and you're rounding on patients. I think that definitely would play a role in it. Personally, I don't do well with fatty meats. I never have. I don't like duck. I tend to lean into lean cuts of meat. I've always been that way. I have a child that's the same way. I think it's just some genetic-- It's this desire, like, we acknowledge. It's not that my body has trouble breaking down fats, because I eat healthy fats, but I don't eat a lot of healthy fats. I can definitely mitigate a carbohydrate load, if I'm exercising. Today, I lifted. And so, I'll probably have some fruit this afternoon after my dinner. 

But with that being said, I would not have been able to eat the way I do now, if I was still working in a hospital and had little kids. I acknowledge that my N of 1, what works for me now is largely because I'm an entrepreneur and I can break my fast whenever I want to. Generally speaking, I don't have to worry that little people are going to stick their fingers in a light socket when I'm trying to eat. Whereas now they largely-- I always say, they're free roaming mini adults right now. They're very self-sufficient for the most part. So, it's hard for me to answer that question because I just don't know. Even when I was in the beginning stages of perimenopause and I noticed that I had that drop off in my appetite, I really think and I haven't been able to get 100% good answer on this, because I've asked a lot of people. I think it's a combination of the muscle changes that impact insulin sensitivity in late 30s, early 40s. That [unintelligible [00:41:28] even though I was always lifting and eating properly, etc. 

And then I do think that there's some loss of estradiol signaling in the gut that may also impact that as well. Again, I haven't gotten great research to be able to back that up. But in talking to other researchers and clinicians, that's been the working hypothesis of why that starts to happen. But we also know that physiologically, we don't need as much food as we get older, whether some people that bothers them or not. I think Mark Sisson, who I know you just interviewed on the podcast as well, he kept saying, “Heck, I don't eat nearly as much food as I used to and I do just fine with--" As a guy, he's like, “I do just fine having one really big meal a day.” He's like, “I'm happy.” So, so many factors.

Melanie Avalon: Yeah, it’s so interesting. It's interesting that you and I are both really similar with that lean meat thing. I still do, basically, lean meats most nights, but probably once a week, I just crave salmon and I'll just do a bolus of really fatty salmon. And I've found that that works for me right now. It's really interesting just how the body changes over time and how your cravings change. 

Cynthia Thurlow: Absolutely. One thing I've noticed and this applies to our audience and listeners, too, is that I can tell where my estrogen levels are by how much cravings I have. I generally don't crave. I crave healthy food, but I don't have cravings that wake me up at night or I don't think about chocolate constantly or something sweet. But estrogen is this cravings modifier, if there's any way to explain it that when our estrogen levels are optimized, it helps with insulin sensitivity, it helps with those cravings, it helps buffer. 

And so, a colleague of mine and I were talking about how we can tell when women are in this perimenopause/menopause state. And a lot of people, they're never full. They might have just eat a meal, but they still don't feel full. And a lot of that can be this diminishing levels of estrogen. And so, really being proactive about getting your levels tested, knowing where they are, and if appropriate, getting some support and that could come in the form of supplements, that could come in the form of hormonal replacement therapy depending on the individual.

Melanie Avalon: Gotcha. So helpful. I so love having you on this show and having your knowledge about all of this. It makes me so excited. I'm like, “Oh, so much good information for people.” Okay, her next question. She says, “I've been doing well with IF. I learned midway through that Splenda and my black coffee and apple cider vinegar with seltzer was a no-no or so called “dirty fast.” I still found success before I learned this, but now, I have saved those things for when I open my window. The days when I did this and I don't open my window for 18 to 20 hours, can this dirty fast still be beneficial? What I mean is, I'll wake up, I'll open my window with coffee and half in half, I'll get sidetracked. I'm a touch ADD. And then several hours later, I've done 18:6, not on purpose. So, do you think my body does not repair like it would without the cream?” This is a good question.

Cynthia Thurlow: I think it's important to keep in the context of dairy as insulinemic. And if you are at your goal weight or whatever metrics you're tracking, you're happy with where your progress has been made, I wouldn't stress and worry if one day out of the week you have a little bit of half and half or cream in your coffee. However, and I'm laughing because I was just at an event this past weekend with Vinnie Tortorich and some other metabolic health people and getting clarification, because some half and half in your coffee for one person might be a teaspoon and for another person, it might be half coffee, half, half and half and that was the joke that Vinnie was telling at this event was that get clarification.

If you're having a teaspoon or a tablespoon, that's probably not going to derail your overall fasting regimen. But if you're derailing your weight loss efforts, because you're consuming a lot of fat, like, what Melanie and I were just talking about, fatty meats. Just fat in general. Fat is calorically very dense. It's great, but too much of any one thing is not beneficial. I think it really depends on what your goals are, but I don't want anyone that's listening to stress that if one day of the week, they decide to have a teaspoon of cream in their coffee that somehow that makes them a bad faster or a dirty faster. It's always in the context of what are your goals, what are you shooting for? If you're weight loss resistant, that's probably not the best choice I would rather that you just use-- 

You can change the flavor profile of black coffee with things like cinnamon, which can boost insulin sensitivity. You can use high-quality salt like Redmond's. And we'll include a link to Redmond’s. I love Redmond’s. They are such great salt. But it can really change the flavor profile, if you're struggling with how bitter coffee can be. But also remember, bitter means that there's a high polyphenol content in the tea or the coffee that you're drinking and you don't want to diminish the net impact of the benefits of those bitter compounds.

Melanie Avalon: That makes me want to go on a really quick tangent. Actually, two thoughts. One about the cinnamon. I'm interviewing on Monday, Ari Whitten. You said you are interviewing him, right? 

Cynthia Thurlow: I think in February. 

Melanie Avalon: Yeah. I haven't read his first book about red light therapy. But his new book is called Eat for Energy and he just goes into all the topics about diet and sleep and it's very supplement focused. So, what type of compounds and supplements can benefit that? It was interesting. His chapter on blood sugar, he goes really hard pushing the cinnamon. I didn’t really considered cinnamon that-- I knew it had those effects on blood sugar, but he really makes the case for having it with every meal, which was pretty interesting. 

Cynthia Thurlow: Like how much in terms of quantity?

Melanie Avalon: He recommends a teaspoon added to meals.

Cynthia Thurlow: Okay, so, it's not a lot. Obviously, when I was doing research for the book, it was something that really stood out as something that could be certainly efficacious. And so, I've recommended people sprinkle some in their coffee, but a teaspoon is a good amount.

Melanie Avalon: And it was interesting, because I do remember you talking about it in the book. And then I was just very, I guess, surprised about the link to which he talked about it. He talked about it and vinegar, which she talks about taking. Oh, since you said it, people are going to really be wondering. [laughs] You don't think or do you think how does cinnamon affect the fast in coffee?

Cynthia Thurlow: Well, it changes the flavor profile, but it's supposed to help improve insulin sensitivity. I don't recall from the research that I looked at so long ago now. It seems it was million years ago. What was the therapeutic amount? I would have to go back and do some digging. But it's certainly not something that is going to break a clean fast. I think that's the distinction our listeners are probably focused on. But it's oftentimes the hook that I get people interested in using black coffee is use Redmond salt or try cinnamon, and almost everyone is able to ease that transition. It just helps curb that bitterness of the plain coffee.

Melanie Avalon: I keep mentioning Mark Schatzker’s book, The End of Craving and I finally just finished both. I was so proud of myself, I read both his other two books in three days. Steak and The Dorito Effect. His books are just amazing. And now, I really want to re interview a carnivore figure like Paul Saladino, or Shawn Baker, or something. Because he doesn't talk about in the context of the carnivore movement or anything. But he makes a really good case for-- Because you're talking about polyphenols and the bitterness and how that might relate. He talks about how basically kids don't often like these bitter vegetables and stuff. And the carnivore movement, people will use that as an example of why we shouldn't be eating plants because they're saying like, “Intuitively, our bodies know not to eat it.” And then we conditioned ourselves to eat it.

When he makes the argument that the body is learning to eat it. It wasn't so much intuition that we shouldn't have eaten it. It was that our body had to learn and adapt in order to get the health benefits from it. I just thought that was a really nicely reframed on that concept with plant toxins.

Cynthia Thurlow: Yeah, and I think the one thing that I fervently believe having gone through a healthcare hiccup is that there was a time posthospitalization that the only thing my body tolerated was meat. But then I got to a point where I started to crave vegetables. I think as your gut heals, you become more tolerant to those plant-based compounds. I truly, truly believe that the average person should be able to eat a variety of macronutrients and not just protein. That's my feeling. I went through nine months of just eating meat. Anytime I tried to reintroduce a vegetable, it was a disaster. No exaggeration. But I think as my gut has healed. And it ebbs and flows. I don't think it's ever going to be perfect. I find myself craving certain things. It'd be interesting to see. I know that Paul is perhaps a bit more outspoken than Shawn. And I've met Shawn in person now. So, I feel I can comfortably say that. But it would be interesting to see what their take would be.

Melanie Avalon: Yeah, I'm just curious. When you were doing the meat only, were you still eating leaner cuts or did you eat fattier cuts?

Cynthia Thurlow: It's funny. I've never and it drives my husband crazy, because I'm sure for everyone listening, all of our meat prices have gone up exponentially. And my husband was grumbling about how the two ribeyes he bought were a third of the price is the filet that he bought for my birthday or whatever piece of fish I'm having. There is a cost difference, but I just feel so much better. I just don't do well with very fatty meats. And just you'll never see me using or eating duck fat fries, or using lard or tallow. Not that there's anything wrong with using those products. I just don't do well. It'll feel like I have a rock in my stomach and it's really unpleasant. I just tend and always have-- always done much better. Throughout my lifetime, it's not something that's just new to this stage of my life, but I've always craved leaner meat. 

Now, we're getting into minutiae. But for me, cartilaginous, very textured meat was just never something that appealed to me and I have a child that's the same way. There's team lean meat. There are two of us. And team fatty meat, they are or two on the other side. And generally speaking, when we buy a cow share it works out beautifully, because [laughs] there are 50% of the house likes leaner cuts and 50% is more flexible. So, it all works out. How about you? Did you always know that you were this way or was it just an evolution as you got more mature?

Melanie Avalon: When I first started doing keto back in the day, I ate fattier meats then and I ate a lot of coconut oil. [laughs] But in the context of a low-carb diet, I was much better with it. When I switched to high carb, I couldn't do the fattier meats and the high carb. It’s like I felt the fat in my system and is very like-- it’s like a feeling. But basically, the next day I just felt more sluggish. I felt I wasn't clearing the fat as much. I just feel better on lean meats. I find when it comes to craving, the thing I crave is the protein. I just crave that lean protein. So, I like fattier meats.

If I were to sit down to have a meal of a ribeye, it would be delicious, but I wouldn't feel as good from it. I don't think and that's why I was curious about when you're doing only meat. If I was doing only meat, I would be very curious. I might be better with fattier meats then, but I haven't done that in a while.

Cynthia Thurlow: No. They sent me home from the hospital telling me to eat a standard American diet. Essentially, a devoid of fiber, highly processed. And my gastroenterologist and surgeon were like, “You know exactly what to do.” And so, I recall it had to be stewed meat or braised meat. It had to be really, really cooked meat. I remember even reintroducing shellfish was a problem. It was a long journey. But I could eat a cooked burger like a champ and I probably ate burgers every day. It was one thing that my body really had a strong desire for, but it had to be a plain burger, nothing on it. Salt and pepper. That was about it.

Melanie Avalon: Yeah. I have one more thought. Oh, so, reading his book, Steak, where he basically travels all over the world. I learned so much and tried steak in all these different countries, and tried to figure out what makes a good steak. And after reading that book, I was craving a steak. I have quite a few steaks in my freezer from ButcherBox. I will say, “Oh my goodness.” Have you had the ButcherBox filets?

Cynthia Thurlow: Mm-mm.

Melanie Avalon: They're really, really good. I love carpaccio. I pulled it out and I was like, “I wonder if I can make my own carpaccio from this?” I sliced it rare and it was so tender, it was so delicious. So, plug for ButcherBox. They have really good steaks. And our link for them is butcherbox.com/ifpodcast. I'm not sure what the offer is right now, but they usually have really good offers going. I'm excited to interview him, but I think his takeaway was that the thing that most affects flavor, it's funny how just how different the different ideas are in different countries about what makes a good steak. The USDA prime concept is just about the marbling. It's nothing about the flavor. I don't know, I think it's very misleading as far as what makes a good steak. 

And then, wait, there was one other fact. Oh, this blew my mind. The criteria for Angus steak is so arbitrary that you would think it would be from the Angus breed, but it's not. They do it based on-- The criteria is like, “Is the cow black?” Because most Angus cows are black. And then all these other criteria, but none of it is actually is it an Angus steak. So, there's all of these crazy nuances in the steak world that just blew my mind. I was like, “Oh, wow, can't trust a label.”

Cynthia Thurlow: No, I think that goes for anything here in the United States, [laughs] unfortunately.

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Melanie Avalon: So, her next question. She says, “Due to my health history, I get bloodwork frequently. My glucose is often, high 109. I don't understand. It is frustrating, because I don't eat processed foods much at all. Could alcohol affect this? Before you answer that, if I'm being honest, I'm drinking more now than ever during COVID-19, but I mostly clear liquor, tequila, and vodka, and yes, wine several days a week. If my sugar is up, can I still be successful at IF? This is very confusing to me?”

Cynthia Thurlow: Well, clearly, it sounds like you're in perimenopause. You're going to be prone to less insulin sensitivity. If you're fasting blood sugar's 109, that's high. I would be asking for a fasting insulin. I would want to know an A1c, I want to look at inflammatory markers, like, a high-sensitivity CRP, and you would be an ideal person to have a glucometer or continuous glucose monitor without question.

A lot of things impact blood sugar, sleep quality, stress management, overexercising, inflammatory foods, gut health, toxins. I would say at a bare minimum you need a deeper dive. But a blood sugar of 109, if it's been that level multiple times, it's a wakeup call that you're setting yourself up to develop some degree of insulin resistance. It's time to have an honest conversation. If you're still eating gluten, and grains, and dairy, and alcohol, and processed sugars, all of those things can exacerbate insulin resistance. So, it's really a wakeup call.

Melanie Avalon: I agree. And just speaking to the alcohol piece specifically, typically drinking alcohol in the fasted state will actually lower your blood sugar. But if you're having alcohol with your meal, it also might lower the blood sugar effect, but it's very individual. For some people, it might have the opposite effect because the body's processing the alcohol. And so, the glucose from your meal is staying elevated in your bloodstream. Again, it's a thing where you're going to have to monitor with a continuous glucose monitor to see how it's affecting you specifically, but agreed with Cynthia that it's concerning. So, definitely something to look further into.

Not to put a Band-Aid on it with a supplement, but something like berberine might also be helpful supplement to integrate into your protocol. She also says, “She thought she was in perimenopause, but then she had a full-blown cycle” and she just wanted to point that out. I think she was saying this, because I cut down this question a little bit. But Gin had an experience, I think where perimenopause and the definition of it and then having thinking you're done, and then you're not, and so, she was referring to that. Do you see that a lot with your patients, by the way, Cynthia, people who think they're at a certain point with perimenopause or menopause and then have a surprise?

Cynthia Thurlow: No, not all that often, because so, let me backtrack. Over the past two years without getting controversial, if anyone received a vaccine for a virus that we have been in a pandemic over, I'll just put it that way. I've seen a lot of women in menopause that have started menstruating, again. I've seen women that are peak cycling years that have gone on to have months, and months, and months of irregular shorter, longer cycles. So, certainly, if you fall underneath those parameters, that may be directly related to the vaccine. Let me just put that out there. 

Number two, generally, if you've gone 12 months without a menstrual cycle, you are menopausal. If you suddenly start bleeding after that 12 months that absolutely warrants seeing your GYN or your internist to make sure there's no other reason to explain why that would happen. If someone is not yet in menopause, and they have 18 months without a menstrual cycle, and then they get one that's obviously different. This is a question that is best directed to your healthcare professional. But again, if you're 51 years of age or older, that's the average age in the United States for menopause. And you have not had a period for 12 months or longer and you suddenly get a period, you need to let your GYN know that requires follow up with them. And it could turn out to be completely benign, however, you need to make sure it's not related to another issue.

Melanie Avalon: She has one last question. She said, “She's not been able to drink diet soda or regular soda since chemotherapy, which is a blessing in disguise. And she also can't consume anything with artificial lemon or lime. They all give her a horrible aftertaste. But she can have cherry or orange Tootsie Rolls, which is strange.” She says, “She knows we're not doctors, but do we have thoughts on why.” I will just say, I don't know, but I will say, after reading, I mentioned it already. But in particular, The Dorito Effect and learning the mind blowingness about all of these artificial flavors, and how they're created, and what they are, and what they do, and how they signal to our bodies. It doesn't surprise me that going through something like chemotherapy, I don't know what happened, but it has some effect and how your body is interpreting these flavors. So, that's not surprising to me.

Cynthia Thurlow: Very common for patients that have gone through chemotherapy to develop. Sometimes, it can be transient, short-term, but also long-term taste preferences. And I think it would be highly dependent on the type of chemotherapy that you received. Whatever chemo toxic agent you received, some of them may have more lingering long-term effects than others. That would be my first guess. But certainly, something to discuss with your oncology team. If this is someone else that's listening that's experiencing this, I have someone on my team who very openly talks about being aggressive cancer thriver. That's how she refers to herself. And I fervently agree with that that she definitely had a period of time transiently, where she had some taste preferences, or things that tasted metallic or cottony in her mouth that ever resolved. But I think it's largely dependent on the type of cancer you're being treated for and the type of chemo toxic drug that you received.

Melanie Avalon: Thank you. That was so helpful. I did not know that. [laughs] And also, Doreen, sending you lots of love with that whole situation with your cancer and we're happy that you caught it early. And it sounds like the chemotherapy is going well. So, very happy for you with that. She says, “I want to thank you, ladies. I feel blessed beyond words to have been able to include you in my daily life. Love and light.” Oh, she goes by D. So, thank you D for your question, which apparently was our episode. 

Cynthia Thurlow: It was a long question, but our next episode, we're going to get a couple for sure fit in. 

Melanie Avalon: Yes. The show notes for today's episode will be at ifpodcast.com/episode279. Those show notes will have a full transcript. So, definitely check that out. If you would like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can follow us on Instagram. We are @ifpodcast, I am @melanieavalon, Cynthia is @cynthia_thurlow_. And again, a reminder to enter the giveaway for some goodies from Cynthia. If you have her book, Intermittent Fasting Transformation or if you don't, if you get it, which you should, just leave a review on whatever platform you bought it on. It's super easy to do and just send a screenshot of that to questions@ifpodcast.com to enter to win and this is US continental residents only. Yes, I think that is all the things. Anything from you, Cynthia, before we go?

Cynthia Thurlow: No, thank you. Keep those great questions coming. Obviously, today was an unusually long question, but we will definitely get to several on the next episode we record. 

Melanie Avalon: Awesome. Well, I will talk to you next week. 

Cynthia Thurlow: Sounds good. 

Melanie Avalon: Bye. 

Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team. Administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week.

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