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Nov 10

#447 – Feasting Without Guilt, Healthy Fast Food Choices, Indulgence Vs. Hedonic Food Consumption, Diet Pressure, Male Vs. Female Societal Eating, If It Fits Your Macros, And More!

Intermittent Fasting

Welcome to Episode 447 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, biohacker, founder of AvalonX, and author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine, and Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC

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Enjoyment or indulgence: What draws the line in hedonic food consumption?

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TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)


Melanie Avalon
Welcome to Episode 447 of the Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat, with no calorie counting, then this show is for you.

I'm Melanie Avalon, biohacker, founder of AvalonX, and author of What, When, Wine. Lose weight and feel great with paleo-style meals, intermittent fasting, and wine. And I'm joined by my co-hosts, Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC. For more on us, check out MelanieAvalon.com and BarryConradOfficial.com. You can submit questions for the show by emailing questions at iapodcast.com or by going to iapodcast.com. We would love to hear from you. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time, and get ready for the Intermittent Fasting Podcast.

Hi, everybody, and welcome. This is episode number 447 of the Intermittent Fasting Podcast. I'm Melanie Avalon. I'm here with Barry Conrad. Barry, how are you today?

Barry Conrad
Hey, everyone. Hey, Mel, I'm doing amazing today. I am back in New York and I am currently looking out the living room window at the City Lights, the New York City Lights, actually, literally. So I feel pretty amazing.

Glad to be back on the show with you. How are you doing? How are you doing on this great Tuesday?

Melanie Avalon
Yes, I am. I'm so jealous of your view. It just sounds so beautiful and amazing and such a vibe. It is a vibe.

Outside your window. I am good. I had the, so when this comes out, okay, so this comes out. Oh, well, this comes out November 10th, which is the day after my birthday. Wow. Wow. That's weird to think about.

Barry Conrad
It's exciting to think about.

Melanie Avalon
Eh.

Barry Conrad
No?

Melanie Avalon
Yeah, yeah, another year older.

Barry Conrad
Another year younger, you know.

Melanie Avalon
No, you're younger. It's funny how you go from remember like when you're little like your birthday is the most the most exciting thing.

I don't know if it was for you. But for me, it was like you look forward to that. Like it is everything. And then or no, did you not?

Barry Conrad
I did, but what, are you doing anything for your birthday this year? Or did, okay, it hasn't happened yet, but are you going to do anything for your birthday this year?

Melanie Avalon
I'm actually currently trying to... I was actually working on that today. I think so, actually.

I think I'm gonna get... It's TBD. My dad might come in town and we might see a show, but I might turn into a group thing. If you wanna come, I really wanna go see Taylor Tomlinson, the comedian. Do you know her?

Barry Conrad
I've heard of this person.

Melanie Avalon
Yeah, she has her specials are on Netflix, but she's like younger and I just think she's really funny. I went to her first touring special a few years ago.

I love comedy shows. I love going to comedy, but I don't go that much because I don't know any comedians. Like I, it's like, I know I like it, but I don't, it's kind of like knowing that you like a certain cuisine, but you actually don't know anything about the cuisine. So you can't just like order it, you know? Like I wish I knew more comedians that I thought were funny. So she's one of the few that I actually have seen and really like, and what are the odds that she's coming here the day before my birthday for her show at my favorite theater in LA, or sorry, in Atlanta, the Fox. So I feel like I have to go.

Barry Conrad
You have to go and it's not a, you know, what are the odds of the timing is perfect. So you've got to make it happen.

You got to do. Also, I didn't actually know that you were into comedians. I didn't know that you liked, you enjoyed that.

Melanie Avalon
I feel like I didn't know that either. And then I realized I did. But you know, whenever you go, do you like comedians?

Barry Conrad
I do like comedians. I don't get to enough shows, but I have. I did go to a stand-up night just before I left Sydney, and I loved it. It's funny. I love laughing, so I'm all for it.

Melanie Avalon
Like, laughing is so good for you. So whenever I do, like, on the rare times I go to a comedy show, I'm like, this is so healthy for me.

Like, I need, and you're like, it's, you're with people, you're laughing, assuming it's, you know, like a style of comedy that, because people have different styles. So assuming it's a comedy style that you appreciate and think fun, I think it's funny.

Barry Conrad
That's awesome. That sounds like a good nod out to me.

Melanie Avalon
I think so. And then especially if my dad comes in town and it could become a group thing, you could come.

Barry Conrad
You know what, I'm going to check my calendar to see what the situation is.

Melanie Avalon
Actually, check.

Barry Conrad
Yeah, but I also do need to get your address. Thank you. Can you please send me your address?

Melanie Avalon
Yes, I will give you my addresses because I have, well, yeah, I have my address, but then I actually have like a package receiving facility. So I have like two addresses type things.

Barry Conrad
Oh, fancy. So like, what's the address that you would receive things?

Melanie Avalon
It depends if it's a letter or flowers or packages. Letters and flowers go one place, packages go somewhere else.

Barry Conrad
That's like, yeah, it's so weird. Is that an American thing that they, if it's an apartment complex, like is two different, no, it's so confusing to me.

Melanie Avalon
I feel like it's whatever, because like when I first moved here, everything just came to my address. But then it was such a hassle that they installed these lockers for a while.

So a lot of apartments do like a locker system, so you have a different address. But now we have just this off state. I was really, when they started it, I was like, this is not going to work. Because the place the packages go to, like the address I would give you is a completely different city. And I was like, so I'm going to have my packages go to a different city every day and then you're going to bring it to me. But they do.

Barry Conrad
That's so interesting. Whatever works.

Melanie Avalon
I know. In Australia, is everything always just one address?

Barry Conrad
No, I feel well, yeah, I get like no one's ever told me I've got like unless they have a PO box for fan mail or something. It's like usually just one address.

It is very so far in my limited experience. American, very American situation.

Melanie Avalon
I know you're gonna have to keep me updated on things that you find to be so American, you know? Like...

Barry Conrad
I did a self-tape earlier today, and the guy was saying, you are see say air con and we say AC and like, you know, in the slate, we say like full body slate and you guys say long shot. It's like just like all these isms like there's always like whatever it is.

Melanie Avalon
What do you guys say for sleep?

Barry Conrad
like to do like a long, like a slight, but then do like a long shot. But in, apparently here you get, you say, there's like a full body, full body, uh, slate. Yeah.

Melanie Avalon
Yeah, there's probably just like tons of it. And you say, I mean, we say AC or air conditioner.

Barry Conrad
We say aircon, the aircon is good.

Melanie Avalon
That sounds like a flight. It does. Like a flight, like a airline. I'm flying air con.

Barry Conrad
Yeah, actually it does. It actually really does.

Melanie Avalon
That's funny. Oh my goodness. Well, speaking of slates and movies, quick plug. Because when this comes out, hopefully it's still in theaters, you know, it should still be in theaters.

So this for me personally, this past weekend, I saw I know I've talked about on the show before and told you about it, Barry, but my friend Carmen and me has this first feature film playing clothes. And it is doing so well on Rotten Tomatoes. It doesn't have the audience score yet, because it's not, it's not out in theaters yet. It has like 60 reviews. And it has last time I checked 87% on Rotten Tomatoes, which is amazing. It's doing so well. It stars Tom Blythe from The Hunger Games and Russell Tovey. And it's an incredible film. This was my third time seeing it. They were screening it at the Out on Film Festival here in Atlanta, which is an LGBTQ film festival. And I went with a group of friends. And again, my third time seeing it. And it's just a stunning, stunning film. And it's doing so well. And I got to see Carmen. So it's actually going to be in theaters nationwide, October 3. That's incredible. If you go to magpictures.com slash plain clothes, Magnolia Pictures is their distributor. And you can see where it's showing. It's showing in a handful of theaters in most states. So it's actually going to be showing here at our legendary one of our like one of my favorite theaters in Atlanta movie theater is called the Terra Theater, which is like a it's just like a legendary theater here that shows mainstream stuff and also independent films. So everybody go see plain clothes. And Barry, you have to meet Carmen because he lives in New York a lot. I love that. He's like all over but he's often in New York. So you guys have to meet up.

Barry Conrad
And I'd love to see the film if I can. I've actually written down the URL now, magpictures.com slash plainclothes, so I can check out locations. I'd love to check it out.

Oh yeah, you should. That's so exciting. And that's, I'm so happy.

Melanie Avalon
So in New York, it's going to be showing, oh, in Syracuse. So he's from Syracuse. Oh, at IFC Center 5 in New York, that's probably in the city. That one is actually, oh, it's already playing there.

And then it's going to be playing at, oh, OK. So for the bigger release, it's going to be playing at Rosendale, Williamsville, Orchard Park, Watertown, Who Keeps Sea? So five different other theaters, but then it looks like the one I mentioned before is probably the New York City one. How good is that? I'm so proud of him. And he's literally just one of the nicest, kindest, most magical human beings that I know. So love you, Carmen. And Carmen and Barry, you guys have to meet.

Barry Conrad
It's gonna happen. Let's put it out there. Let's do it. Awesome.

Melanie Avalon
Awesome awesome

Barry Conrad
Also, speaking of seeing things, guess who I'm going to see tomorrow.

Melanie Avalon
Who you're going to see? Yeah. Not what you're going to see?

Barry Conrad
It's a music artist.

Melanie Avalon
Oh, can I have a hint?

Barry Conrad
Female music artist, pop, is actually friends with Taylor Swift.

Melanie Avalon
friends with Taylor.

Barry Conrad
Well, based on exchanges and just like, you know, stuff on stage that they've, you know.

Melanie Avalon
Oh, I bet you're going to see Sabrina Carpenter.

Barry Conrad
No, but that's a really good guess. Okay. Okay, I'll give you another clue. They have brown hair. Brown sort of wavy hair. I think wavy hair.

Melanie Avalon
Can I have another hint? What does it start with L? If you if you say it's not if you say it's not Lana, don't tell me it's Lana

Barry Conrad
You would die if it was Landau, I know it's not Landau, but yet.

Melanie Avalon
I would die if it was Lana.

Barry Conrad
You would, wouldn't you?

Melanie Avalon
Yeah, I would. Oh, Lord. I actually was looking, I was almost, I was thinking of going to her concert here. I didn't. Oh yeah, fun. Do you like Lord? Obviously you're going.

Barry Conrad
And also she's a Kiwi, so you know, gotta support Aotearoa, support New Zealand artists.

Melanie Avalon
Oh, she is?

Barry Conrad
Yes, she is.

Melanie Avalon
And I know that.

Barry Conrad
Yeah, she's a New Zealander, so going to go and support. And I love, especially some of her older stuff, so I can't wait to... Madison's Great Garden is going to be a vibe, can't wait to go.

Melanie Avalon
Oh my goodness. Have you been in Madison Square Gardens?

Barry Conrad
I've actually never been to Madison Square Garden and this is the thing like I realized being in New York like everyone comes I guess most places in New York like America just everyone tours here right so much better.

Melanie Avalon
Oh, my goodness. I was thinking of going when Billy Joel was having his last show, but then he canceled it. Did he? Mm-hmm.

Barry Conrad
He would have been amazing to see, he's a goat.

Melanie Avalon
Yeah, oh my goodness, let me know how that is. Ah, it's so fun. Have fun.

Barry Conrad
You're about to freak out, like, is it Len Lomé?

Melanie Avalon
Oh, I would have died, yeah. Do you like her new album?

Barry Conrad
I haven't heard it, but I did hear that Taylor Swift has this whole new thing coming out and like a film and everything. Is that, can you know about that?

Melanie Avalon
Oh, yes. Well, that'll be in the past by the time this comes out. But I will be going to that. Yes, I will be going and I'm dressing up because I'm actually seeing Fiddler on the Roof on Saturday.

And then I'm going to go to Taylor Swift's movie on Sunday.

Barry Conrad
There you go, I can't wait to hear all about it.

Melanie Avalon
I know. All right. Shall we jump into some fasting related things?

Barry Conrad
Let's do it.

Melanie Avalon
Okay, so I'm so excited about the study that I found.

Barry Conrad
You were saying that you're excited to bring the study, right?

Melanie Avalon
Yeah, I think it's really unique. The study is called enjoyment or indulgence. What draws the line in hedonic food consumption? The reason they were doing this study and contemplating these thoughts is actually for the tourism industry. So disregard that because I just find what they discuss really, really interesting.

But it's basically looking at the idea of indulgent consumption and hedonic consumption. So the idea of like eating a lot of food and gratuitously maybe or feeling like it's hedonic, feeling like it's indulgent, maybe feeling guilty, it breaks it down into two different forms. Because it's saying that we tend to lump that into one thing when really there's hedonic consumption and there's indulgent consumption and it all comes down to goal conflict. So basically, if what they consider hedonic consumption, that's doing something because it's pleasurable, it's enjoyable, it's fun, but it's not in conflict with your goals, then there's indulgent consumption, which is doing something that feels excessive, you feel guilty about it, you feel bad about it. But the takeaway is that not all pleasurable behavior, and especially behavior that might involve a lot of seeming quote, excess. So I'm relating this to fasting because I'm thinking about how you and I, you know, like in our one meal a day, have all this food, and we have like our big meals and everything that technically because that's not in conflict with our goal, that to us is hedonic consumption, not indulgent consumption. And so pleasurable actions only become indulgent if it conflicts with your higher goal. So be that health or weight loss or even like money savings or self control. So many people doing fasting might think, you know, if I had this big delicious feast in my eating window, am I indulging in a way that you know, you should feel guilty about and what this study is proposing. Again, it's not talking specifically about fasting, but with the theory, it's saying no, not necessarily it's saying if you eat in your window, and it's aligned with your fasting practices, and your meal supports your goals, then that's just hedonic enjoyment. It's not indulgence.

But if you were to push past your satiety, choose foods that are sabotaging your health goals, not aligning with what you want to be eating, or if you feel like it's derailing your progress, then it would become indulgent because of the goal conflict and no longer hedonic. So I think it gives like a cool new reframe on the idea of guilt that we might assume comes with eating these, you know, big amount of foods in our eating window. And it makes it much more personalized, and it can help with a mindset shift. So you know, people, when people are eating, especially if they're having like a big one meal a day type situation, they can ask themselves, okay, like, was that indulgent? Was that excessive and I feel guilty and it's in conflict with my goals and it's in conflict with my my fasting or my food choices?

Melanie Avalon
Or is it in line with my fasting, it's supporting my goals, it's hedonic, it feels good, but it's not something indulgent to feel quote, guilty about. So yeah, what are your thoughts on this on this concept?

Barry Conrad
This is really eye-opening because it seems really simple, but it's totally like it's a reframing. Like you said, it's kind of all about the context. It's almost like not the what, but the why.

Like what I found really eye-opening is that the enjoyment only turns into indulgence when it clashes with the goal. So for example, like someone can look at, you know, can you hear, are you eating all that food tonight? They can see that as an indulgence, but they don't realize that that's all in line with my goal and the same for you. So it's just like it's all about the context of it. Like you still will experience the pleasure in the moment, but it's more like the little voice in your head afterwards is whether it's going to say you're going to regret this later or not, depending on your goal. You know, yeah, it's so interesting.

Melanie Avalon
Exactly. And the reason I find it so refreshing to read is because I'd sort of been dancing around this concept in more of a nebulous way. And that I think... Because it's speaking to the idea of pleasure and it's saying pleasure isn't something that you have to necessarily feel guilty about. And I find it really interesting that I think we are, depending on how you were raised or what religious background or family background or traditional background or philosophical background, and people can have different ideas. So this is just me pontificating.

I know for me, the way I was raised, I think it was this idea that things that are pleasurable are probably not good, like something to feel guilty about. And so this is a more like a clinical look and it's like, no, no, no, there's pleasure and it's literally pleasure. And the guilt comes in if it's in conflict with these higher goals that you have. So I agree with their hypothesis, basically. And I find it really freeing. I think it's a good reframe for viewing anything that you're doing pleasurable in life.

Barry Conrad
I actually was about to, I was thinking exactly the same thing while you were talking that it kind of applies to so many areas of life, right?

Melanie Avalon
Mm-hmm. Yeah

Barry Conrad
Not just food.

Melanie Avalon
yeah, money, relationships, like anything related to, quote, pleasure. So yeah, and like I said, the actual article is talking more about how it applies to the tourism industry.

And I'm trying to remember how I found it. I think it's because I was searching, I was really curious if there was any literature, scientific literature on the idea of indulging a lot in like an eating window and having guilt about it. I was just curious if there was like, thoughts on that. And so that's how I found it.

Barry Conrad
That's an amazing find. What's something that you really enjoy that never feels indulgent to you because it aligns with your goals? What do you reckon?

Melanie Avalon
So two thoughts there, which is a great question. And this is what's interesting, because I think I needed, like, I think I needed to find this article for me because I still, even though I've done one meal a day fasting for how long? Almost 15 years, I think, and it supports my goals. I love it. I genuinely enjoy it. I don't have goal conflict with it.

And still, still, I sometimes feel guilty, like still. And I'm like, where is that coming from? And I think it's coming from, like I said, well, two things. One, how I was raised with a perspective of like pleasure coming from a religious perspective. And then two, in society, eating a lot of food, just because eating a lot of food in society is typically seen as an indulging thing that you would feel guilty about, because it's not taking it into the context of having it in like a fasting, feasting pattern. So it's like something I personally have not been able to completely lose. So do you ever have that feeling?

Barry Conrad
No, I guess now that I think about it, I always really look forward to my one meal a day like it's such an event like I prepare everything and it's like it's never like a whim like it's always. This is what I'm gonna have and I can't wait like I'm it's like an incentive and then when I have it it's like I feel like a king of feel like I'm feasting.

Melanie Avalon
It might be like a male-female thing too.

Barry Conrad
Really?

Melanie Avalon
Yeah, also go back to that. Sorry to interrupt that that like sparked my memory. Yeah, because you were saying you feel like a like a king.

Barry Conrad
Yeah, I feel like I'm feasting and also at the same time when I feel fine with that, but then when people more if I share what I've had and people comment, then I can sometimes unintentionally will kind of go, Oh, is that too much? Am I indulging too much?

Even though I know that's not the case, but it's more like the outside perspective. It can be like, Oh, that's too much or that's that's excessive or that's not healthy. Or you're doing too much. You're eating too much. There's other people that need to eat that. But in the moment, I'm like, it doesn't conflict with my goals. It's not hurting me. I'm having all this abundance of food and drink and it's great. Yeah, it's interesting.

Melanie Avalon
Oh my goodness. Yeah. So that's a big, that's a big epiphany moment for me.

Cause I was saying it was two things for me that the guilt was coming from like religion and then society looking at fasting choices. But I think it's also the male female thing. Like I think there's like, if you're as a female, as a, like a biological female, the messaging, like the messaging towards women for as long as I can remember. And I think it's still this way is like women shouldn't, you know, be on a diet and should not be overindulging. And like you should be dieting compared to like men where it can be like this like masculine manly thing to like eat a lot of steak. There's not that guilt aspect that I think is just saturating society when it comes to females eating.

Barry Conrad
Do you think that that makes total sense? It's so sad that you say that that's pretty much still a thing now. It's still the expectation or like a silent expectation or not silent.

Melanie Avalon
And well, you know, what's also hard about it is, so I think that is the silent expectation. And then you're also not supposed to diet either. So like, you know, like when we, the women can't win because it's like, it's like, oh, you need to be dieting and you need to be restricting and you need to be like this thin body shape and every and everything. But also if you do that, then you're not accepting yourself and oh, now you're over dieting and now you're over restricting.

So don't do that. So like, literally, the lack of acceptance is horrible.

Barry Conrad
That sucks. I'm sorry that that's that's the reality.

Like I'll never understand, you know, not being a female, but not by and I'll never understand that. They're really, it's not reasonable. And I can see how that could confuse a lot of biological females, what to do, what to eat, when not to eat, what, you know, when to die, when not to die, what's too much, what's indulgent, you know, like what is indulgent then one P, like one quarter of a piece of cake or whatever it is.

Melanie Avalon
Like, yeah, like when does it become indulgent? Like, which bite makes it indulgent versus not, you know? Like, where do you cross the line?

Barry Conrad
So you've actually been thinking that.

Melanie Avalon
well, it's very subconscious. It's very, very tiny. And it's very subconscious. But it's like, so I'm not like actively it's not like every time I eat normally my mental experience of eating is very similar to you. And that I literally look forward to my one meal day so much every night, not in like a craving, I'm hungry, I need food away just in like a I love doing my work during the day. I love being productive. And then I love like being done with my work and like having my meal like it's so fun. And then the food tastes like eating food after fasting compared to like eating constantly throughout the day, it tastes so much better. Like the first bite just tastes so good. So I love like being in that moment.

And then I love the food. And then it makes me feel really good. And still again, it's not like I'm actively thinking it but there is underneath everything still a little tiny little kernel of guilt. I guess it's I guess it's guilt that yeah, that this is either in conflict with my religious upbringing or it's in conflict with what society says about what I should be eating. It's in conflict with like being a woman eating all this food.

Barry Conrad
I think it's really great that you are self-aware enough to share that I feel this and also I know that it's not true, it would be harder I think if you felt this and you didn't know what to do with that.

You mentioned like you're bringing societal messaging, silent expectations and not so silent expectations and then also bringing up the study, it just simplifies all this dogma.

Melanie Avalon
I agree. I think awareness is so key. So when it comes to all this, because I've just said a lot about my mental, emotional feelings about this, but what I think is really important is A, like you said, awareness. So being aware of these different views and voices in your head and where they're coming from. And it's okay to... I think it's okay that they're there because we don't even know where thoughts come from. I was reading a book yesterday that I'm prepping for the show and she's talking about how still we don't know where thoughts come from. They literally just pop up. You can't control what pops up into your mind. And people think with meditation that it's about not thinking. No, it's not about not thinking. It's about being aware that thoughts come up and that you are not those thoughts and that you can let them just pass through. So I think that's really important.

So I'm not saying that I'm a bad person. Not that you were saying that, but I'm not saying that it's bad. I'm having these thoughts. I'm just saying I'm aware that they're there. And I think others can be aware of them in their head as well. And then two, I also don't want to have a victim mentality. So even if this is the case in society, which I think it is, that doesn't mean I am forced into... That I'm a victim of society or that I'm forced into eating one way or the other. I can still make agency to do what I want to do. And if that's eating fasting with one meal a day, then that's what I'm going to do. So no victims as well. That's my soapbox. Wow. Soapbox.

Barry Conrad
No, honestly, Melanie, that was actually incredible. Thank you so much for sharing that because it's just you being really honest.

And I think I know that so many listeners will get so much out of this right now. So I'm so glad you found the study because I'm certainly thinking about it. I'm going to read up more about this after we finish making a note because it's interesting and it just takes the pressure off of you as well, you know, it really does.

Melanie Avalon
Yeah, I think that's the takeaway is that it's like this like sigh of relief that we don't have to funnel everything into this guilt lens, that there are options of how we view this. And I'm so enjoying this conversation.

Thank you so much. This is like one of my favorite conversations I've had on the show. So thank you for

Barry Conrad
Well, thank you for bringing it up. And of course, this is a big and we'll have to do pipe be offline. It's just really interesting.

Melanie Avalon
Farron, I always talk after. I feel like we're going to be going down the rabbit hole.

So awesome. And I would love to hear listeners thoughts on this as well. I should post, I'll post in the Facebook group to get some engagement going around this for sure.

Barry Conrad
Wait till people get a lot of this i think so many people gonna have so much to say imagine the confusion so many people feel like i feel tormented by this guilt and i don't know where it's coming from and that's that's a big struggle that a lot of people go through especially with food.

Lots of other things but food especially i mean a lot of the times you know.

Melanie Avalon
Yeah. And so actually in my book, I talk about the first time I can remember. I can literally remember the first time I became aware of this concept of dieting in society and this need that you should be dieting. Really? Yeah. It was when my older cousin that I really looked up to, I heard my aunt tell my mom, I don't know, I heard some family exchange and they were saying that my cousin was on a diet and I was like, what's a diet? And it was like this idea. Yeah. And I just remember that. Never since then I was like, Oh, like maybe I need to be on a diet to lose weight. So yeah, it's really interesting.

Barry Conrad
Pretty crazy.

Melanie Avalon
Well, okay. Well, on that note, I was wondering, I guess it would actually be a good segue. Speaking of perspectives of guilt and things like that, should we talk about the fast food stuff? Yeah, let's do it.

So I find this really interesting because when it comes to speaking of guilt and food, I feel like fast food locations are not to be judgmental. But if a person has, quote, like guilt around eating somewhere, like it's fast food places, you know, it's often associated with unhealthy food choices. So I was really curious, I asked in my Facebook group, which again, for everybody friends during my group, it's called IF Biohackers, intermittent fasting plus real foods plus life. Barry and I are in there. We talk a lot with you guys. So definitely join. And I posted a poll. And I was really curious because what I posted was I said, if you had to eat a fast food meal, what would you choose? And I was curious if people would go the route of like, speaking of the study, I'm being indulgent. I'm just going to eat what I want to eat, like all the things, or they're going to give options of like healthy versions of things that you can eat at fast food. And we kind of got both. And I'll be curious, Barry, because I don't know which, which of these restaurants they have or which of these fast food places they have in Australia. So should we go through them?

Barry Conrad
Let's go through them. I'm curious. I've just actually caught live literally in real time. Just commented in on the thread

Melanie Avalon
Oh, somebody just commented while we're talking? Yep, just now. Oh, that's, I love it. That's amazing. Okay, so, okay, well, McDonald's. Do they have McDonald's in Australia? Yes.

Barry Conrad
They're definitely at McDonald's in Australia.

Melanie Avalon
Is it different? Have you been here?

Barry Conrad
It's better in Australia.

Melanie Avalon
I bet. How's it better?

Barry Conrad
The meat tastes better. The fries taste better.

It doesn't taste as quote unquote fake. It's better in your gut. I find to digest it. I don't know what's different, but it's, it's definitely, it feels for lack of better words, fresher or more real, even though it's, you know, processed, very ultra processed.

Melanie Avalon
I completely believe that for sure. So if you were, if Barry, if you were to, because okay, if I were to eat at McDonald's, I would just order lots of burgers with no bun. I'd be like, can you give me like 20 burgers? I've actually been, it was funny, because I don't remember the last time I went to fast food. I've actually been having this random like urge to go somewhere like McDonald's or Burger King or something and do that, like order like 20 burgers and like see what it tastes like. I think that would be really good.

Oh, one. Just to see if you like it. Oh, true. I guess I probably should start there. Yeah. Good idea. Before I order 20. So Susan says McDonald's fish with a half bun, fries and diet coke, usually when traveling by car. Also Arby's beef with a couple of curly fries. If I'm trying to be good, then Chick-fil-A grilled chicken cubes. Do they have Arby's or Chick-fil-A in Australia?

Barry Conrad
They don't have Arby's or Chick-fil-A, but I will say I love me some Chick-fil-A. I haven't had it in a while, but it's pretty good. It's not too bad, actually, in terms of badness.

Melanie Avalon
You know what it is? Do you want to know what it is? Tell me. It's one of the ones that I think is growing up, I thought was really healthy and it's actually shockingly horrible if you look at the ingredients.

Because you're thinking like, because you're thinking like chicken, like chicken, you know, this is great, but the, like the fried versions are, oh my gosh. And then the grilled version even has all this stuff in it. I've, I've gone down the rabbit hole of trying to find the most like unprocessed form of meat that you could get at a restaurant, at a fast food place. And I think Arby's, if you get their beef, I don't think it has stuff in it. Well, Arby's roast beef. Okay, never mind. It has beef, water, salt, sodium, phosphate, sometimes a salt solution. I think the best you can do honestly is go somewhere like Burger King or McDonald's and get just the burger if you don't want stuff added. Sabrina says in and out. Well, in and out. Have you been to in and out?

Barry Conrad
I love In-N-Out so much, and actually, okay, Mel, In-N-Out's actually really good because they cook the meat fresh there and they also have like these bundler's burgers there like just in lettuce. It's really good.

Melanie Avalon
Yeah, and they're like, they taste really fresh.

Barry Conrad
they're really delicious because they cook it all fresh, even the fries are fresh. It tastes like old school as if you're in another era.

Melanie Avalon
I miss In-N-Out from California. So Sabrina says, In-N-Out triple flying Dutchman, mustard fried with chopped chilies, soda water with lemon and fries with a side of mustard for dipping.

Andrea, I haven't heard of this. Runza, do you know what that is? Or is that a food? She says cheese, runza and frings with the best ranch. If you know, you know, I clearly do not know.

Barry Conrad
I don't know, what's Runza?

Melanie Avalon
We don't know I'm seeing if it's a if it's a restaurant or it's oh it is a place Well, it looks good I've never been there Okay, Holly says fresh kitchen. I don't know what that is

Barry Conrad
I don't know that one of the...

Melanie Avalon
That sounds good. Yeah, people are giving like, some people are giving like, healthy answers. And some people, not so much.

Amy says, Super Chicks. I don't know what that is. David. Oh, here's one. Chipotle. Have you been there?

Barry Conrad
I have been to Chipotle. Chipotle is not too bad because it's like burritos and whatnot. It doesn't feel so bad and it's like, you know, rice and steak or chicken. So that's, to me, that's not so bad to me.

Melanie Avalon
Chipotle you could totally make work, you know, like you could get you. Yeah, I think you could or like I could order at Chipotle and Feel good about it You always just have to go look up because you have to look up if they're adding stuff to the like the beef and things Because you'd be surprised at different places what they might add, but yeah Chipotle Okay, and then we got another in and out Laura says protein style burger from in and out.

I agree protein style That's where they put on the lettuce. I think right?

Barry Conrad
That's what it is. Yeah, protein style, that's right. Yeah.

Melanie Avalon
And then, I don't know this, the habit. I haven't been there. Santa Fe beef salad, that's what Nydia said. Nydia, we answered your question last week, in case you missed it.

Nancy says this is an odd answer, but Taco Bell, I'm going to keep reading, but do they have Taco Bell in Australia?

Barry Conrad
I actually don't think that they do, and they might do, but I've never had it there, but I have had it here, not in New York, but in America, and I don't love it.

Melanie Avalon
You don't love it.

Barry Conrad
I don't, do you?

Melanie Avalon
I mean, that there's two answers to that. Do I love it? Like, emotionally, mentally? Like, I would, it would taste so good.

Barry Conrad
Really? Maybe I got the wrong thing. Maybe I just ordered the wrong thing.

Melanie Avalon
It's like the greasy Mexican food that you have growing up from fast food, but yeah. Is it Taco Bell that has like the quesadilla that's just so good? I think so. They have a quesadilla that's just delicious, like to die for.

Oh, man. Okay, so Nancy says, Taco Bell, bean burritos minus cheese plus their hottest sauce. I find two to three of these to be a satisfying one meal a day, along with black coffee and lots of sparkling water. I have tested this out on an extended road trip, always makes me feel really good, even with the physically grueling circumstances and suboptimal sleep. Oh, cool. So she gets the bean burrito. She removes the cheese and she adds hot sauce. And she has two to three of those. And then the rest of the day she has black coffee and sparkling water. Cool, Nancy.

Barry Conrad
Sun, do you like hot sauce? Or have you ever liked hot sauce? What's your thoughts on hot sauce? Because it's delicious to me.

Melanie Avalon
Yeah, I don't like hot sauce. Do you?

I love it. That's good to know. I need to know that's, I'm running and making a note of that. I feel like people are either hot sauce people or they're, or they're not.

Barry Conrad
Have you seen that show? Is it Hot Ones?

You know, it's a show we interview celebrities and he goes through like a series, I wanna say like nine chicken wings and each wing has a different level of hot sauce.

Melanie Avalon
Oh, I think I've seen this.

Barry Conrad
It's really fun because it gets harder and harder and the thing is the guest can't give like they have to see if they can finish the hardest wing. It's really funny.

Melanie Avalon
I know what you're talking about. Yeah, that's what's the hottest thing you've tasted.

Barry Conrad
I've eaten a whole chili like a day, like a massive chili in India.

Melanie Avalon
help us that.

Barry Conrad
You know, that face was on fire for like a long time.

Melanie Avalon
Yeah. Have you ever had like, I don't know, is it the ghost pepper that's supposed to be like the one of the hottest?

Barry Conrad
I haven't tried it, but I do love spicy in general. I can do with that, but I can. I love spicy.

Melanie Avalon
I think I might talk about this before you know humans were the only species that engage with that seek out spicy stuff which creates pain for like no reason like there's no like no other animal does that.

Barry Conrad
You have mentioned them. It's very fascinating, but it's not. That's pleasure.

Melanie Avalon
Yeah, because animals seek out bitterness.

Barry Conrad
I guess it is pain too, but...

Melanie Avalon
Yeah. It's interesting that it's pleasure to some people, not others. It's not pleasure to me.

Oh, my goodness. Okay. Let's see what the next one is. Oh, and then Damon said he also does bean burritos, sometimes also. Shout out to Damon. And then Teresa Quodoba, or Doba Quodoba. Do you know that? Okay, that or Chipotle burrito bowl. Yes, there we are. Steak and chicken, extra meat, extra guacamole. That sounds good. That sounds yummy. Do they have Culver's in Australia?

Barry Conrad
They don't. You have so many. We have so many things here. So many options.

Melanie Avalon
Chrissy says Culver's kids meal with the free scoop of custard. Maybe she's having flashbacks of childhood or Chick-fil-A grilled chicken without the bun, add Colby cheese and fruit. It depends on the week I have had.

So this is, I'm going to use this as an example. So like Chick-fil-A grilled chicken. Like you would think that that's just chicken, right? Let me tell you what's in it. Chicken is boneless, skinless chicken breasts containing up to 17% that's one, that's almost one fifth of the chicken. 17% solution of water, seasoning, yeast, extract, onion powder, sea salt, garlic powder, sugar, salt, corn, maltodextrin, gum, Arabic, natural flavor, lemon juice concentrate, vinegar solids. Then they add chicken flavor, which is chicken breast meat, chicken stock, salt, and maltodextrin, modified corn starch, dried vinegar, apple cider vinegar, water, I'm not done yet, soybean oil, sugar, more sugar, cane, molasses, salt, spices, chicken, fat, dehydrated onion, yeast, extract, corn, maltodextrin, I already said that, but it's here twice, lemon peel, dehydrated garlic, red bell pepper, paprika, parsley, xanthan gum, natural flavor, including smoke and calcium, um, de-sodium, EDTA, hyaluric canola oil. So we got seed oils. This is all just in the chicken with dimethyl polysiloxane added to reduce foaming.

Barry Conrad
That's scary to hear.

Melanie Avalon
That was all in the chicken.

Barry Conrad
in this little chicken breast that you think is just chicken but it's not.

Melanie Avalon
And we're only, I'm not even reading the rest because we be here all day. That's just the chicken.

Then you go into what's in like with the bun. Oh, and then they just add like canola oil in general to it.

Barry Conrad
Okay, so this is another thing because with Jimbros or people, not just Jimbros, but people who do go by the calorie deficit train of thought, some people I've seen online are like, whatever goes, goes as long as it's within the quote-unquote calorie count. What's your thoughts on that?

Because some people use fast food within their macros per se, like calorie count for the day. You know what I mean?

Melanie Avalon
Yeah, well, I mean, if I mean, that works for people, there's like, if you if it fits your macros. And we do know that if you're doing calorie restriction, and you're losing weight, like there are health benefits to that. So multiple things can be true. You can be calorie restricting, eating all of these additives, losing weight, getting health benefits.

And that doesn't change the fact that some of these compounds aren't good for you. And could be, you know, you could be having like immune reactions, people have problems with the seed oils, you know, the processed sugars, all these gums and flavors and additives. So basically, yes, it can work. Yes, you could even be, quote, healthy. Is it ideal and optimal for you? I don't think so.

You know, just, and like why eat, I mean, I know, like money and things like that and flavor, but you also could eat chicken without all of that. You know, and Ian, if you wanted to add some flavor, you could add like some mustard or salt and pepper rather than I mean, that was the such a long list.

Barry Conrad
It was.

Melanie Avalon
So I remember this is what I mean by like to play like the difference between me thinking the healthiness and then reading this thing is just like shocking to me.

Barry Conrad
Would you, okay, maybe putting in the spot, but what fast food would you eat if you had to? Like out of all those options, because you said some of those options are like not too bad, what would you, or where would you go?

Just, okay, just out of the list that we've read here today.

Melanie Avalon
So, because I want to answer that and I want to hear your answer. Can we read the rest because I might get more ideas? I might get more ideas from the answers.

Damon said, I've been eating Arby's on my road trips. I get the biggest meat sandwich they have. Like I said, Arby's had a little bit of additives, but not, not that bad. Joy said, had to, oh, it literally makes me gag thinking about it. If I had to, I guess I could choke down a no meat egg McMuffin. What's funny is like, I would love to do this. And it would be a had to cause I would feel emotional going back to our first conversation, I would feel emotionally guilty about it, but I would, it would taste good.

So Amy Chick-fil-A spicy Southwest salad with creamy salsa dressing. Teresa Taco Bell is the only one that's gluten free. Oh, interesting. So I'd pick that, but if there were no consequences, I get a sub from Jimmy Johns. Oh, do they have like subway and do they have any sub places? In Australia.

Barry Conrad
Yeah, they have subways everywhere in Australia. I actually like subway now and then. It's not too bad.

Melanie Avalon
Subway, I feel like, again, that's something where I think you'd be surprised, people, not you, but people might be surprised if they looked up ingredients like in the chicken, like you would think it's just chicken. I don't think it is.

It is more approachable and that you can, you know, make things work for you. And then let's see. So the rest of them are Phyllis, said Chipotle, or In-N-Out. Kate, I'm a big fan of Roll Up. Not sure if that's a chain that's exclusive to Milwaukee or not. I think I've never heard of it, but I suspect there are others similar. They have fresh spring rolls and salads. I love me a big mama roll with tofu, veggies, and extra freshmen. Kenna, says Applebee, Tex-Mex Shrimp Bowl. Do they have Applebee's in Australia?

Barry Conrad
Don't put it actually every name that you list off I'm just like I want to try these places just because it all sounds really good even though, you know, it does

Melanie Avalon
I mean, it tastes good. Tastes amazing.

Stephanie says Chipotle, Anna says Chipotle, bowl, keto, extra main guac, berry. You said for fast food in the US, Shake Shack, In-N-Out Burger King, Popeyes. Are any of those in Australia?

Barry Conrad
Burger King was in Australia, but we call it a Hungry Jax. It's kind of like the same thing, but just a different name.

Melanie Avalon
Whoa, whoa, whoa, whoa, whoa, whoa. Is it the same company?

Barry Conrad
I don't know, but I remember like in New Zealand, for example, it's Burger King, and in Australia, it's Hungry Jack's, it's, I don't know, but there are, I think there are Burger Kings in Australia. I'm not too sure why it's separated, but it's pretty much, it's same-same. Okay, let's see.

Melanie Avalon
Burger King Hungry Jack's is the second-largest franchise of Burger King. It's a Burger King franchise. That's fascinating. Okay.

Barry Conrad
So when I go to Hungry Jack's, I get like a double whopper. Like the burgers do taste really good there. Like they taste.

Melanie Avalon
Like the grilled taste that they have to it. Yeah.

Barry Conrad
It tastes better and it's thicker meat like patties, you know.

Melanie Avalon
Yeah, I used to, my favorite thing growing up was a kid's double cheeseburger from Burger King. Man, my favorite like fast food meal. Oh, do they have Wendy's in Australia?

Barry Conrad
They have that so okay this is weird in Australia we have Wendy's but it's only desserts in New Zealand we have Wendy's and it's like the full when he's like burgers and stuff I don't know why it's like that.

Melanie Avalon
Wait, so what is it? Frosties?

Barry Conrad
Yeah, it's like, I don't know why it's like that. Let me just look this up because it's weird.

There's no burgers instead of burgers. And yeah, and fast as you'll find soft serve corns and Sundays and hot dogs.

Melanie Avalon
Whoa, hot dogs?

Barry Conrad
Yep. But in New Zealand, it's the full thing. Like you can order burgers and fries and everything. It's really interesting.

I don't know why when I moved to Australia, I'm like, where's the burgers at? It's just like soft, like soft sort of ice creams and like hot dogs and stuff.

Melanie Avalon
Wow, I'm learning so much. Well, to answer your question, and I'm, yeah, I think, so I would have said one thing before reading the poll, but I forgot about Chipotle.

So I think, I have to look up the meat and the ingredients in Chipotle. Like, Have you tried Shake Shack? I actually haven't. I feel like, when did it come out? I feel like it came out after I kind of, I feel like it, yeah, when was it found formed? Do you know?

Barry Conrad
I don't, but the beef, like the patty is not dissimilar to the feeling and the patty of like in and out patty, like it feels a bit more like pressed down beef rather than like a pre-made thing.

Melanie Avalon
Yeah, like, I mean, it looks really good. Let's see.

I want to see, basically, to answer your, oh, here's, I found the ingredients. Okay. Okay, so I would have to do a deeper dive, because I'm not certain if they add Echovole, if they add stuff. Like, if you can get it plain, they probably do, because it's seasoned, right?

Barry Conrad
Yeah, definitely.

Melanie Avalon
Marinated, okay. I think I would, yeah, I might go to a Burger King or McDonald's.

No, actually, no, no, no. I would go to like In-N-Out, somewhere where I know they use good quality beef, like In-N-Out and just get tons of the burgers.

Barry Conrad
Do you remember the last time you were talking about, you know, people eat like these blocks of butter and stuff like that, like, you know, keto, people are, oh, carnivore eaters, carnivore diet. I saw this lady on Instagram, and she, I want to say that her partner is someone that you know, or who follows you or something. I don't know why, I forgot who it was, but she's of Asian descent. And she's kind of like popular on social media.

And she was talking about like a hack you can do for carnivore followers. And maybe and she's like, she went to McDonald's and bought like all these patties and just had the patties and like, apparently, if you ask for it, then it's like, you can get them for cheaper. And it's like, just the patties. I don't know. It's just this hack she was giving people who ate carnivore.

Melanie Avalon
Well, first of all, if you think of who it is, I'd be curious who it is. That's the thing that's surprising is I think a lot of people would think with these options that you could get like, quote, the least additives at somewhere like Chick-fil-A or Chipotle or something.

But if you just want meat and nothing on it, like McDonald's burgers, Burger King burgers, they don't add stuff to the plate. There is the problem, though, with the gluten cross-contamination, I think. But you get what I'm saying? The way to get plain meat is one of the burger places, honestly, probably.

Barry Conrad
That's pretty that's a good that's good to know because it means that you actually can you can make it work if you went to those places if you really wanted to.

Melanie Avalon
I would be worried, though, about the gluten cross-contamination. Yeah, so what would you get?

Barry Conrad
What would I get? All those places I listed, like, are pretty good. If I had to choose one, I've got to say In-N-Out.

In-N-Out's pretty good. I'll get, like, an animal-style fries, double-double, a couple of double-doubles for sure. That's pretty yum.

Melanie Avalon
I forget for the double double does that mean that it's what it like for patty or like what is it like? How does it translate because don't they do like the two by four like aren't there like different numbers they use?

Barry Conrad
Okay, so the double doubles, no, yeah, they're just two B-patties. Oh yeah, so I get two double doubles because one's not enough for me. Just has two B-patties and one double double.

Melanie Avalon
Yeah, I'll get like 20.

Barry Conrad
So I'll get that and then I'll have, yeah, it's just so good. It's so tasty and fresh and the thick shakes are pretty good too. Like they're really thick.

Melanie Avalon
I used to have them. You know, they put a Bible verse on the bottom of every cup.

Barry Conrad
I saw that.

Melanie Avalon
Little hidden, little hidden something. Awesome. Well, this is a cool episode.

Barry Conrad
It's very interesting, all food-centric, a food-focused episode, which I think is important.

Melanie Avalon
emotions, the guilt, ordering differently, all the things. So, okay. Shall we break our proverbial fast? Let's do it. All right. So Barry, what restaurant do you have for us today?

Barry Conrad
Okay, Melanie, I have a restaurant today called the 360 restaurant. And this restaurant, why it's so special, it's record setting.

The wine cellar in the sky holds the Guinness World Record for the world's highest restaurant wine cellar ever at 351 meters elevation. It's the CN Tower dramatic views. So basically, the rotating dining floor and panoramic city views.

Melanie Avalon
made with a rotating dining floor.

Barry Conrad
Bring visual flare combined with the serious wine service and the vibe is meant to be elegant but not overly formal so you go for the view but you definitely stay for the food in the wine and i'm about to send you the where is it you'll see it right now as i send it to you have a look have a look where is it.

Melanie Avalon
What, where?

Barry Conrad
It's in Canada.

Melanie Avalon
Oh, Canada. Canada. I love this. Oh, okay.

Barry Conrad
So you want to go to the the Ellicott.

Melanie Avalon
Okay, wait, I'm looking at a picture. Hold on. Wait, whoa, it's up there. Oh, whoa, whoa, whoa, whoa. That was not what I, I don't know what I was expecting.

Wait, you can, you can do no. Wait, Barry, did you look at the brave the edge walk? Is that where the restaurant is? Do you see this? Did you click this? I do see it. Okay, friends. So this tower thing is like, very tall, you can brave the edge walk and it looks like it looks like they harnessed you to the building and then they let you walk around, because it's round, you get to walk around outside, like free world, like, would you do that?

Barry Conrad
I don't love heights. I don't know if I would do it, but I'd do my best to slight myself up to try, but I don't know if I'd go through with it. It's pretty high. It's really high, isn't it? Look at it. It's crazy. Are you seeing the video playing? Are you watching that? It's nuts.

Melanie Avalon
I, you know, it's funny. So I, I don't want to do it. I don't have any interest in doing it.

Like the walk thing, I could do it though, like, and it's not like something where like there are some things where I'm like, I just I know I can't like I could do that. I don't think I would like it. But I can do it.

Barry Conrad
If I had to do it, I could do it, but I wouldn't enjoy doing that.

Melanie Avalon
Wow, so the restaurant though is right is inside there?

Barry Conrad
Yes, exactly part of that tower. So you know that little top bit there. So if you click on dine at 360 restaurant, I mean, I don't know if you see them. I think it's maybe, yeah, but it's insane.

Melanie Avalon
Oh, local and sustainable. I want to see what it looks like on the inside. Like, I want to see the restaurant on the inside. 360 is what it's called. 360 restaurant.

Barry Conrad
It would be awesome to dine out there. I mean, the car hired it, yeah.

Melanie Avalon
Okay, yeah, so it's like circular. Would you be would you have any anxiety dying and dining inside of there?

Barry Conrad
I wouldn't because I mean, it'd be high, but there's something about it being inside and whatnot.

Melanie Avalon
Oh, is it a chain? Oh, it's a chain because they have a lot of them. It looks like like here's one in Florence. Here's one in is it is it Istanbul?

Barry Conrad
But this particular one has the Guinness World Record for the world's highest restaurant wine cellar.

Melanie Avalon
Oh, okay. Okay, okay, okay. I want to see if it's all the same company.

Barry Conrad
Pretty high though.

Melanie Avalon
Yeah, our spaces. Oh, yeah, is is more than the home of the world's high. Okay. Okay, so menu. Sorry, I got derailed. No pun intended. Okay, so we're doing the menu.

Barry Conrad
So menu and then go into a la carte and then that takes you to another page with Appetizer's main side dishes seafood bar.

Melanie Avalon
Oh my goodness, they use your terminology. Actually, no, you don't use appetizers though.

Barry Conrad
Yeah, we do appetizers.

Melanie Avalon
I thought you'd do entree, main.

Barry Conrad
We do appetizers sometimes, but appetizers mean something different for us. Appetizers is more like an entree type thing. We say entree or appetizer, but appetizer doesn't mean main or entree doesn't mean main, if that makes sense.

Melanie Avalon
Well, according to this menu, appetizers comes first and oh, oh, okay.

Barry Conrad
What's catching your eye?

Melanie Avalon
You know.

Barry Conrad
Mm-hmm. The worst is?

Melanie Avalon
The AAA beef carpaccio, don't tempt me with carpaccio, comes with pine nuts, Parmesan, oyster, oyster, AOE, mustard sprouts, Maldon sea salt. I would get all of that on this side.

Yeah, how about you?

Barry Conrad
I will get the oysters, the dozen oysters.

Melanie Avalon
Oh, to share. I missed to share. Oh, okay. Oh, there's oyster. Oh, okay. Well.

Barry Conrad
I'll get the oysters and then i'll also get the handcrafted 360 charcuterie and cheese because i love a charcuterie situation just to have that.

Melanie Avalon
Can I taste from the charcuterie, the, the prosciutto? Yep. Awesome. Okay. Are you getting half a dozen or a dozen oysters?

Barry Conrad
getting a dozen, half a dozen is nothing. That's like, no way.

I actually, Melanie, when I was in, um, I went to New Zealand for a week and this place had me like eat there and I have to post about it. And one of the things I ordered was an entire dozen oysters, which was amazing for myself.

Melanie Avalon
sounds amazing. I want to like oysters and I won't make this a whole oyster tangent but in theory, in theory oysters should taste good because there's so nutri- like there's so many nutrients in there so I don't know why they don't they taste horrible.

Maybe it's too toxic maybe there's too like too many nutrients and so our body's like we might get like over nutrients too much zinc.

Barry Conrad
It's going to be great when you finally come around to it. But anyway, we're here to mains, mains now.

Melanie Avalon
Yes.

Barry Conrad
And this looks very delicious. So Melanie, what are you going to choose? Because there's a few things I think you'd like.

Melanie Avalon
Okay, so let me have a look-see here. I would like to get...

Barry Conrad
Good choices, right?

Melanie Avalon
So I'm going to get the King Cole Duck, which is pan roasted breast, confit croquette, French beans and partridge berry juice. But I'm going to get all that on the side.

And then also a steak, a Canadian Triple A steak. I will get the eight ounce tenderloin prepared belue, as belue as they will give it to me.

Barry Conrad
You're not going to go rare plus? A little rare plus.

Melanie Avalon
No, blue, blue, blue, blue.

Barry Conrad
Okay, just to zoom out, we are getting like we were requesting a larger table in general so that we can order extra things so I'm gonna actually gonna get three things I'm gonna get a tenderloin as well.

Melanie Avalon
Three things? Oh my goodness.

Barry Conrad
Yeah, Rare Plus, the Spiced Ontario Lamb Chops and the Nova Scotia Lobster.

Melanie Avalon
and what comes with the lamb chops.

Barry Conrad
Yes, the lamb chops comes with beet puree, rapini, pearl onions, red wine jus, and then no Scottish lobsters, cream spinach, fingerling potato, Ontario corn, drawn butter. That sounds incredible and I'm getting a whole one.

Melanie Avalon
lobster.

Barry Conrad
Yeah, a whole lot of stuff.

Melanie Avalon
Can I taste the lamb chops? How are you getting lamb chops prepared?

Barry Conrad
I'll do that medium, eh?

Melanie Avalon
And have I told you my first experience of lobster and crab? So lobster and crab, and let me know if this was your experience.

Do you remember the first time you... Actually, and scallops. Do you remember the first time you had lobster, crab, or scallops, and or scallops?

Barry Conrad
Actually, hold on. Did you say something like you expected it to be sweeter or sweeter than you thought or something like that?

Melanie Avalon
Yeah, just that like all of them they don't taste at all what you think they're gonna taste like at all at all like Shocking to a shocking degree. I thought they were gonna taste like Fishy, I thought they were gonna taste. Ah Very hates it when I say fishy But like I fished can taste fishy. I thought they were gonna taste Like you know the sea and fishy ness and they take like crab and lobster just tastes like sweet Succulent delicious and and scallops. They're all like sweet and yummy.

They're not what you think they taste like honey

Barry Conrad
They're very good.

Melanie Avalon
Wait, what's the seafood bar? Oh, side dishes. Seafood bar. Oh, is this like separate? Oh, we could have gotten some of this as the appetizer.

Barry Conrad
Are some of these side dishes? You may know the seafood bar.

Melanie Avalon
the Seafood Bar.

Barry Conrad
Okay, let's go to the seafood bar, so.

Melanie Avalon
feel like we need to backtrack. So going back to the appetizer, I would also order some things from the seafood bar.

Barry Conrad
What would you get, caviar?

Melanie Avalon
I would have some caviar. Yes. Do you like caviar? Only if you want some caviar.

Barry Conrad
I do like Kevia. Yeah, I love Kevia.

Melanie Avalon
Okay. And then definitely a shrimp cocktail. Oh, wait, they have, they have samplers.

Barry Conrad
Yeah. Look at that sample. It's got like, it's like a tower. Like that looks pretty good.

Melanie Avalon
whoa the tower come okay the tower comes with two lobsters you could we could do that and then you would not get your lobster for the entree

Barry Conrad
Let's zoom back, I mean, let's rewind back. Let's, let's, we have to redo this whole thing. Let's delete the, my lobster and let's add a seafood tower.

Melanie Avalon
Okay, the tower or the three, the tower? The tower.

Barry Conrad
A tower, of course, more food.

Melanie Avalon
Well, there's also the 360.

Barry Conrad
Oh wow, the three saw.

Melanie Avalon
Okay, so for listeners, so the tower has one lobster, 12 oysters, East Coast mussels, Cape Dior salmon gravlax, three-piece jumbo shrimp cocktail. The 360 has two lobsters, 18 oysters, East Coast mussels, Cape Dior salmon gravlax, four-piece jumbo shrimp cocktail, two Fogo Island snow crab clusters.

I think we need to change around because you ordered oysters in the beginning of the appetizer, we could like mix that and instead get this 360.

Barry Conrad
Yeah, I think so too. Let's get the 360 and the charcuterie. Yeah.

Melanie Avalon
Yes. No, and the carpaccio.

Barry Conrad
And the carpaccio and then I'll keep the lamb chops and the steak.

Melanie Avalon
Okay, and I'll get the steak. Okay, I'm glad we figured that out.

Barry Conrad
That sounds like a pretty amazing feast. Any side dishes catching your eye are not really.

Melanie Avalon
Let's have a little look-see. You know what's funny about this? What? Is there ever a situation where a side dish would be like a meat-related thing?

Barry Conrad
Not really, it's always like a vegetable or something like that.

Melanie Avalon
that's how i would do it though like i would want like a side of chicken a side of scallops a side of crab

Barry Conrad
his grilled shrimp.

Melanie Avalon
side of shrimp oh they have they do they have the side of grilled shrimp oh my I don't know if I've ever seen this before like a like a protein side oh my goodness yes add that

Barry Conrad
And I would get, because I do love potatoes of some sort, I would get like, like a baked potato. A baked potato is fine.

Melanie Avalon
What do you get on your potato?

Barry Conrad
I get some butter, some delicious butter, and just salt and pepper, and some braised mushrooms because they're just go down really easy and they're good to have. That's it.

Awesome. Great. That sounds delicious. Well, we're not done. We've got to drink.

Melanie Avalon
We miss the indigenous menu, foraged mushroom soup, hunter style rabbit stew and sweet corn cake. That sounds cool.

Barry Conrad
It actually sounds really good. You know what, I think because of this, we need to also, well, I'm going to order the Hunter style robots too. Are you going to get, you want to try some of that?

Melanie Avalon
They might not let you order at all a cart.

Barry Conrad
Yeah, maybe not. If not, then we will. Yeah, if they do, then we will. If not, then...

Melanie Avalon
You should get that and then I will be.

Barry Conrad
Get everything else?

Melanie Avalon
No, I'm gonna I'm gonna see if I can get like rabbit playing like so can I get some rabbit?

Barry Conrad
Oh my gosh, better than that. Can you get some rubber, please?

Melanie Avalon
I would want that as a thing, like a rabbit, you know, I don't know how you order rabbit, like a rabbit, a rabbit breast, a rabbit filet.

Barry Conrad
Yeah, I'm not too sure what the lingo is for that. Okay, shall we go to the drinks? There's a plethora of options, Melanie.

Melanie Avalon
Yes. Do they have a dessert menu? They have a children's dessert menu.

Barry Conrad
It's pretty that if you got a pre-fee prefix, then there's appetizers, mains, and desserts.

Melanie Avalon
That's only on that menu. There's not a...

Barry Conrad
I'm sure that they could whip something up. Let's just go there anyway.

Melanie Avalon
Okay. Yeah, we'll work with what we have. So from that, I mean, I don't, what would you get?

Barry Conrad
dark chocolate and sour cherry torte, because there's no milk chocolate then, sorry, because I don't love white chocolate that much. I mean, so the best next thing would be the dark chocolate and sour cherry torte.

Melanie Avalon
You know white chocolate is technically not even chocolate.

Barry Conrad
Well, that's disappointing.

Melanie Avalon
It's like certain solids from the plant, but it's not, yeah, I went down a rabbit hole learning about white chocolate.

Barry Conrad
What would you get from this situation?

Melanie Avalon
Honestly, so I would not well, I would get depending on what I like the most I would get a repeat of that because that Tower that we got had a lot of stuff on it so but probably I would get more carpaccio because that's normally the thing that I Like just love love love love love. So probably another carpaccio.

But if I were to get a dessert on the kids menu they have They have a cookie and I love cookies so I might get the cookie

Barry Conrad
I'm glad that you're getting cooked. I think this might be the first time you've ever actually ordered a dessert.

Melanie Avalon
No, I'm not getting it. No, I'm saying if I had to like, no, no, Barry, don't get your hopes up. I'm not actually getting it. I'm saying like, if I like had, you know,

Barry Conrad
What about just like a bite, like a morsel of it? No.

Melanie Avalon
Oh man, I can't wait till we have a meal in real life and we can experience you trying to convince me to have just a bite and my resilient, you know, not having a bite, it's going to be fun. What's fun about it is I think you probably think you can convince me, but the amount of like my, my like boundary barrier there is so firm.

Like you cannot break through. I cannot be broken. It'll be fun.

Barry Conrad
All right, it will be fun for sure. And then drinks? Let's go to drinks and there's so many options. There's rosé there, there's wine, there's, I mean, there's white wine, red wine, cocktails.

Melanie Avalon
So what would you get? For me, it takes a while because I have to look through.

Barry Conrad
Okay, to start, I always like to get a cocktail first. That's just my kind of way in any restaurant, then I'll usually go into the wine.

So I'll go with the fare of the place, which is, there's a 360 sunset, it's like a trademark 360 restaurant, so I'll try that. And then I'll go onto maybe like a rosé. Why not? Since I'm on that rosé vibe at the moment.

Melanie Avalon
I like that they have 5 ounce pours.

Barry Conrad
Get like a bottle, bottle of rosé, for the table. Perfect.

Melanie Avalon
Okay, which one the the French one? Yeah, and then for me I would have to do my whole little like research see what's organic Oh, which by the way a little fun fact for friends.

So I have learned that you can Take a photo of the wine menu at a restaurant go to chat GPT say Are these organic you can like ask all your questions like are these organic which ones are low alcohol and then it will give you like all the information that you need right away, so that has been a game-changer and Just really optimizing my restaurant experience because now I can quickly get information So I would do that and then based on that I would pick a wine that is organic lower alcohol dry all the things

Barry Conrad
Sounds great or Melanie, this would be a feast very high in the air, but quite a feast. Like this is a lot, this is probably one of the most amounts of food we've actually ever proverbially ordered.

Melanie Avalon
I think so. I was thinking about that because the tower alone that starts it off is kind of like five meals for two people in one thing.

And then you still kept the Turkutari board and the carpagio. To be fair.

Barry Conrad
You know that seafood is so much easier to eat and digest, it's not the same as eating like a steak, you know?

Melanie Avalon
Yeah, no, we've talked about this before. And honestly, like thinking about it, I can't even envision.

So if I was only eating seafood, I don't, I can't even envision feeling super full from it. Even if I ate like pounds and pounds, like there's some, it's weird, because there's something in like chicken and steak that gives you that satiety feeling that just doesn't come from seafood.

Barry Conrad
I mean, I think salmon graveleks, which is absolutely delicious. I had it during Christmas. That's probably going to be the only thing that's going to be salmon, salmon graveleks.

Melanie Avalon
What is that? Was that what I read on this menu earlier, actually?

Barry Conrad
Yeah, it's like it's kind of like smoked salmon type situation, but like with salty, the way it's prepared, it's very, it's very delicious. But that's probably the only thing that will feel filling, per se, but I could just eat seafood for days and just it'll just be so feel very hedonic. Let's say that way.

Melanie Avalon
Oh, hey, yes, yes. That was literally what I read earlier and I didn't know what it was. Okay, so salmon, Gravelix. So it's like smoked salmon.

Barry Conrad
Kind of like that, that's sort of the way it's prepared, but it's like overnight you press it down. It's like it's a whole situation, but it's actually very, very good. It's very good.

Melanie Avalon
Awesome. Okay. Well, good find. We must go. Oh, and there's a picture of the tower. Do you see it?

Barry Conrad
Oh, whoa, whoa, whoa, whoa.

Melanie Avalon
Look at all of your little oysters at the bottom all 18 of them hanging out

Barry Conrad
You're going to have so many, I can't wait for you to try it.

Melanie Avalon
Oh my gosh, that's a good find. I did find out, so my dad, he loves, he loves like fine dining. And so he would love to come, except I just found out he has a horrible fear of heights, so I don't think he could actually come with us next time.

Next time. Well, this was so, so fun. Good find friends. Thank you so much for being here with us for all the things. If you would like to submit your own questions for the show, you can email questions at ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can get these show notes at ifpodcast.com slash episode 447. That will have links to everything that we talked about. So definitely check that out. And you can follow us on Instagram. We are ifpodcast, I am Melanie Avalon. Barry is Barry underscore Conrad. All right. Think that's all the things. Anything from you before we go?

Barry Conrad
Thank you once again for tuning in, everyone, and we'll talk to you next week.

Melanie Avalon
Alright, talk to you next week!

Barry Conrad
Okay, bye.

Melanie Avalon
Hi! Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed.

If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by podcast doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

See you next week!



Nov 03

#446 – Clean Breath While Fasting, Fasting And Blood Clots, Essential Oils, Natural Depression Solutions, Fasting For 50-Year-Olds, Stubborn Weight Gain, And More!

Intermittent Fasting

Welcome to Episode 446 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, biohacker, founder of AvalonX, and author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine, and Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC

SHOW NOTES


SPONSORS & DISCOUNTS


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LINKS

Featured RestaurantProhibition

Essential Oils Recipes: A 52-Card Deck for Healing and Home: 50 Recipes

The Healing Power of Essential Oils: Soothe Inflammation, Boost Mood, Prevent Autoimmunity, and Feel Great in Every Way

Melanie's DIY Breath Spray Recipe

STUDIES:

Intermittent fasting inhibits platelet activation and thrombosis through the intestinal metabolite indole-3-propionate

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Original theme composed by Leland Cox, and recomposed by Steve Saunders.


Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.


TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)



Melanie Avalon
Welcome to episode 446 of the intermittent fasting podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you.

I'm Melanie Avalon, biohacker, founder of Avalon X and author of What, When, Wine. Lose weight and feel great with paleo style meals, intermittent fasting and wine. And I'm joined by my co-hosts, Barry Conrad. Actor, singer-songwriter, and creator and host of Banter with B.C. For more on us, check out MelanieAvalon.com and BarryConradOfficial.com. You can submit questions for the show by emailing questions at iofpodcast.com or by going to iofpodcast.com. We would love to hear from you. Please remember the thoughts and opinions on this show do not constitute medical advice or treatment. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine. If it's that time and get ready for the intermittent fasting podcast. Hi everybody and welcome. This is episode number 446 of the intermittent fasting podcast. I'm Melanie Avalon and I am so excited to be here with Barry Conrad because listeners, we have not personally recorded in a while. So this is so exciting. Welcome back to America.

Barry Conrad
Thank you so much hey mel hey listeners it's so good to be with you today and so good to be back on the pod you probably don't really record like notice because we've done it in advance but we haven't. Record it in a hot second so it's really really exciting to be back now i'm stoked how you how you feeling.

Melanie Avalon
I am good. I actually, I picked out a question to ask you during our little chat.

I mean, you've already seen it because it's in the prep doc, but Damon said, didn't even know you stopped recording. Like you just said, people don't realize. You guys must have done a lot of future shows to prep. How was the show? So listeners, Barry was in Destiny, the Melbourne Theater Company in Australia, the lead man. How was it? How'd it go?

Barry Conrad
It was incredible. Honestly, Melanie, I finished the season just feeling so much gratitude, so much happiness. It went way beyond what I could ever have expected.

The reviews were amazing. The audiences were amazing. This role has been like a role of a lifetime for me. It's been the most challenging but the most fulfilling role I've ever had as an actor. It's just really been a game changer. I had the best time. I got to have the people that I love there as well come and see it from New Zealand and abroad. Words can't really capture how much it means to me. From the beautiful work that Kirsty Marillio created who played the female lead to the direction from Zinzio Kenyo and just the joy of working with the amazing cast that we had bringing Ezra Jones, the character that I played to life, was so meaningful, serendipitous and honor. I have to give a massive shout out to the whole team for making my Melbourne Theatre Company debut a dream. I absolutely loved it.

Melanie Avalon
I am so sad I could not go. I wanna watch it. Will I be able to watch it? Is it gonna be recorded anywhere?

Barry Conrad
You know what goes with theater you go to enough theater to know now just never translates on screen i mean it was yeah it was filmed for an archival but that's not that's not you know.

Melanie Avalon
unless it's like I feel like they did a pretty good job recording Hamilton on Disney Plus, you know, if you have like a whole, you know, really intense thing like that.

Barry Conrad
you're just gonna have to come see me perform in New York.

Melanie Avalon
I know.

Barry Conrad
when that happens.

Melanie Avalon
Wait, I know. I literally like I'm there. I'm like front row gonna be there. I'm so excited. It's gonna be amazing

Barry Conrad
Would you do your, you know how you do your signature walk down the aisle whenever you go to, are you going to do that?

Melanie Avalon
Yes. But you know what, for you, Barry, I will not enter second act late. No, definitely not. No. I know. Normally, I kind of come late. Why?

Barry Conrad
What are you doing?

Melanie Avalon
I thought I've told you this before, have I not told you this before?

Barry Conrad
No, I didn't know it was regular.

Melanie Avalon
it's two reasons. So reason one is, this is like when I'm at the Fox Theater and they have this beautiful marquee club with like wine and food and things like that. And I just don't like stressing. And so I sometimes end up being there a little bit too long.

And then if you miss, like if you miss, if you're not right there when it starts, they kind of hold you sometimes until like after the first song. So by that point, you might as well just wait a little bit longer. So that's one reason. And the second reason is I really like the experience of watching, like walking down and watching the show, like while walking down the aisle.

Barry Conrad
That's really funny, I didn't know that was the reason.

Melanie Avalon
Uh-huh. Yeah, but I won't do that when I come see you, I promise. You won't have to look for me walking down at the top of Act 2.

Barry Conrad
see the silhouette of hair and this long gown. Yeah. I just think it's

Melanie Avalon
fun. But in any case, so you said that this what you said this was your most favorite acting role, serious acting role, intense acting role. What did you describe it as just now?

Barry Conrad
It's the most challenging and the most rewarding. Yeah, definitely.

Melanie Avalon
Was this your first, like, play lead or because they've done a lot of musicals and stuff.

Barry Conrad
Yeah, I've done lots of musicals, but this is my first play and male lead in a play as well, and it's just all acting. There's nothing to really hide behind. Not that you're hiding when you do musical, but there's often a song that you can find a break. You can sing and recover, but this is just all out there, lots of dialogue, big stakes acting-wise, and there's nowhere to hide, which has actually been the best lesson for me, Mel, because I've really walked away from this feeling more bold and confident in what I do than ever before, and just allowing myself to be seen on stage and just going for it.

What a treat. No words. I feel so, hopefully, you can hear through my voice, but I just feel so happy, so grateful that I've experienced that.

Melanie Avalon
That's so incredible. Wait, so were you on the entire time? Like no for each act?

Barry Conrad
No, we wasn't on the entire time, but it was in most of the scenes, so there's not sometimes you were from like intense anger to levity to crying to, you know.

Melanie Avalon
And and I kind of like stalked the theater because I love looking at venues also, I was trying to make sure That my flowers got to you. I was like trying to figure out like the layout of the theater It looked like the perfect size too. Like it looked like it was a nice size where it's like Substantial and large but also it looked like it looked like it felt close up in the front like with seats and stuff

Barry Conrad
Okay, first off, I have to say, listeners, Melanie sent me flowers for opening night. I was so taken aback.

I got into my dressing room and saw these amazing flowers and I'm like, Melanie, what? And she was, she was like, I was stressing that it wasn't going to get to you. It's like, I love you.

Melanie Avalon
I was really stressed. They were blue, right?

Barry Conrad
They're very blue and so you hit the money right on the head.

Melanie Avalon
Yes, awesome. The venue was a nice size that you appreciated.

Barry Conrad
Yes, it was definitely a nice size. It was substantial enough and not too small, not too big.

I couldn't really... I don't know what you're like when you have performed Mel, but I actually can't allow myself to see the people. I have to kind of block it out. I can't do it.

Melanie Avalon
Oh, really? No. Oh, my goodness. This is a mind-blowing moment for me.

Why? I'm thinking about how... Oh, wow. I'm having an in-real-time moment right now, because whenever I go to a show, one of my favorite things is trying to connect with the actors on stage, and now I'm realizing some are probably just completely blocking us out. Like, they don't even see us.

Barry Conrad
It sounds rude, but it's-

Melanie Avalon
Oh, that's funny. Oh, wow.

Barry Conrad
No but wait, no but at the end then the wall comes down like in my head and I allow myself to see everyone because it takes me out of the world if I notice people, you know?

Melanie Avalon
Yeah, that's so interesting.

Barry Conrad
But then some people like hey did you see so-and-so in row so it was like how are you doing the scene and finding these people I can't do it.

Melanie Avalon
No, it's funny. I guess like I and I haven't been on stage in quite a while, but I don't like overly look at the I wouldn't overly look at the audience, but I don't think I've completely blocked it out.

Like I would see them. So, oh, yeah. OK, so you won't see me when I.

Barry Conrad
I probably will see. This is what I'll do. When I know people are coming, I'll know they're going to be there. That's enough.

I don't want to know which row. Don't tell me which row or which area because that's going to freak me out.

Melanie Avalon
Well, you already know which row I'm gonna be on.

Barry Conrad
If you like run up the front trying to make eye contact, Barry, look at me, Barry!

Melanie Avalon
Oh my gosh, that's so funny. Well, congratulations. I'm so happy for you.

And I'm so excited that you're back in New York. Now it's time for all the New York City adventures and the U.S. adventures for you.

Barry Conrad
totally white Christmas and the whole thing.

Melanie Avalon
Yeah. Yes. Yes. Right.

Because you haven't had that before. Well, I mean, right? Because you've always lived like it's listeners. Can you imagine being Christmas and it being summer? This is like mind blowing to me.

Barry Conrad
I mean, I can. You can.

You remember the shrimp and the barbie thing we talked about a few shows ago about, you know, the shrimp? Mm-hmm. Yeah. You know, barbecues, all of that kind of stuff. It's very Australian, very not American at all.

Melanie Avalon
where are all the the um and when does this air so this episode airs hold on a let this actually this episode airs november 3rd so when this comes out it will be winter

Barry Conrad
very much.

Melanie Avalon
Yes, October, November, December are my favorite months of the year.

Barry Conrad
Because Melanie loves to freeze everyone in case you already don't know, pick that up. She likes to be cold and so she can be warm rather than be too hot.

Melanie Avalon
Mm-hmm. I love the cold and you're gonna have to get to experience it here. What are you doing for Christmas this year? Oh goodness. I have no idea yet.

I know I'm seeing like three shows that week. So I gotta figure that out

Barry Conrad
Three shows.

Melanie Avalon
Yeah. Actually, I think I've seen like four Christmas shows. Elf, Christmas Gandene, I don't know, quite a few, quite a few different ones.

Barry Conrad
Speaking of shows Mel speaking of all things festivities and whatnot. I know that you love Disney so much, right?

Melanie Avalon
Mm-hmm

Barry Conrad
Well i have come up with a fun little game for you to play you can.

Melanie Avalon
A game? Yes. I always- I love games.

Barry Conrad
Okay, so this is in theme of Disney, so you're gonna have some multi-choice and you're on, here we go.

Melanie Avalon
Oh, okay. Is this, wait, is this like a quiz? Yeah, it's a quiz. Wait, like a right-wrong quiz? Like, I'm gonna get it wrong?

Barry Conrad
You might get it right, there's going to be multi-choice and...

Melanie Avalon
Okay, no, I'm okay. I'm ready. I'm stressed. Okay, I'm ready. I'm ready. Yes

Barry Conrad
Okay, Mel, which Disney park is home to the restaurant Be Our Guest, which is themed after Beauty and the Beast? Magic Kingdom.

Yeah, you got it. I was going to give you multi-choice. You got it. What makes the Blue Bayou restaurant at Disneyland in California extra magical?

Melanie Avalon
It's inside that Pirates of the Caribbean ride. Ah, you already got it.

Barry Conrad
What's the point of even giving you the multi-choice?

Melanie Avalon
Keep going, this is so fun!

Barry Conrad
At three, at Epcot in Walt Disney World, guests can dine in a giant aquarium at which restaurant?

Melanie Avalon
the coral reef, or is that what it's called? Coral reef.

Barry Conrad
Yes, correct. In Disneyland Paris, what unique dining experience can you have at Bistro Che Remi?

Melanie Avalon
That's a newer restaurant, I believe. I will take the multiple choice. Does that have to do with the ride being there? And if it's not that, then I'll take the multiple choice.

Barry Conrad
A, eat inside a giant teacup. B, shrink to the size of a rat in Ratatouille's world. Or C, dine with Lumiere as your Metra D.

Melanie Avalon
This is a restaurant, not the ride.

Barry Conrad
It's a dining experience, yep, that you can have at Bistro Sherimi.

Melanie Avalon
Okay, because I know in the ride you shrink to a side of to a size of the rat. What was the third one, though? Who is your?

Barry Conrad
You can dine with Lumieri as your matri-d.

Melanie Avalon
Well, I know you shrink in the ride. Oh man, this is like being on who wants to be a millionaire. I'm going to, I'm going to say shrink.

Barry Conrad
correct five which disney park features megalins which is an elegant globe filled restaurant hidden inside a fortress do you want multiple choice

Melanie Avalon
I think I know, but I think it's, don't tell me the choices yet. I think it's either Tokyo or the one in China. What are the options?

Barry Conrad
So A, Tokyo Disney Sea, B, Hong Kong Disneyland, or C, Epcot's World Showcase.

Melanie Avalon
Okay, it's number one or number two. Let me think about this for a second.

Barry Conrad
You're doing great.

Melanie Avalon
Thank you. I'm going to go with Tokyo. Yes. Oh my gosh. Five out of five.

Barry Conrad
What's special about Space 2020 at Epcot in Walt Disney World?

Melanie Avalon
Well, it's the only adults-only lounge. I can tell you more things special about it. There's an elevator that you take up to it. It's space-themed. Is that one of them? Is that the answer?

Barry Conrad
I'll give you the, uh, multi-choice. So A, guests dine underwater in the submarine. Underwater is in quotation underwater. B, the restaurant simulates dining 220 miles above earth. And C, every table has a hidden Mickey.

Two. B.

Melanie Avalon
be, yeah.

Barry Conrad
Correct. Seven, Melanie killing it. In which Disney park can you find Queen of Hearts Banquet Hall, themed after Alice in Wonderland?

Melanie Avalon
What are the options?

Barry Conrad
A, Disneyland Paris, B, Tokyo Disneyland, C, Shanghai Disneyland.

Melanie Avalon
Okay, is it Shanghai?

Barry Conrad
It's Tokyo.

Melanie Avalon
Uh, I missed it. Oh, you tripped me up. You had two tokyos. I went with the logic because I didn't okay.

Barry Conrad
Okay, number eight. The Hollywood Brown Derby in Disneyland's Hollywood Studios is famous for which iconic dish you might need the most to choose.

Melanie Avalon
Is it the grapefruit cake?

Barry Conrad
It's the cub salad.

Melanie Avalon
Oh wait, well, I could have guessed if you, if I've given that, cause they're, they're famous for a few different ones. I would have guessed that if you had given me the choices.

Okay. That one we were throwing out.

Barry Conrad
That's where I got that one. At Carthé Circle Restaurant in Disney California Adventure, the building is a replica of what?

Melanie Avalon
It's a replica of, oh, I know this. One of the options, I'll know it when I hear it.

Barry Conrad
a. Walt Disney's first animation studio, b. the theater where Snow White and the Seven Dwarfs premiered in 1937, or c. the original Sleeping Beauty Castle model.

Melanie Avalon
oh actually okay wait it's a or b wait so either his studio or the premiere place i'm guess what was b

Barry Conrad
The theatre where Snow White and the Seven Dwarfs premiered in 1937.

Melanie Avalon
And the other one is his animation studio.

Barry Conrad
Yeah, it's first animation studio.

Melanie Avalon
Oh, then probably B. You're right. Yes, okay, I can see it, I've been there.

Barry Conrad
Okay this is the last one okay so Melanie if Disney let you design a brand new restaurant which character or movie would you see what after and this is whatever you want it to be.

Melanie Avalon
Okay. You know, that's a really good question because, you know, I would want to go. I have my favorite characters, but also I have to think about the food aspect, you know, like what food do I like? So, cause I mean, obviously I love frozen, but I don't know if I like frozen food.

Am I, where do they have like, uh, I'll probably go with, it could be the emperor's new groove that you could eat at the rec, but that's not a fine dining. I'll Thank you. How about you? How about you for the restaurant?

Barry Conrad
I actually have no idea.

Melanie Avalon
It could be African food.

Barry Conrad
Yeah, exactly. And lots of lots of animal protein, so it's very much me.

Melanie Avalon
Although that's, it's a little bit ironic, because you're like, you'd be eating the animals from the movie. Well, I guess we don't really eat lion, but a circle of life that actually really works, you know.

So, oh my goodness. Well, thank you so much. That was so fun.

Barry Conrad
Yeah, I just thought why not.

Melanie Avalon
All right. Well, on that note, shall we jump into some fasting-related things?

Barry Conrad
Let's do it.

Melanie Avalon
All right, do you have a study to start us off with?

Barry Conrad
I do have a study and the study this week that I'm bringing is called intermittent fasting prevents thrombosis by improving platelet function in humans. This was carried up at Shanghai Zhou Tong University School of Medicine in China by Dr. Zen Wang and his team. It was published earlier this year in Life Metabolism, which is part of the Nature Family of Journals.

Here's the situation. Researchers recruited 80 healthy adults, 40 men, 40 women, all aged between 25 and 45. None of them had any chronic health issues, none were taking medication, and their body weights were in the healthy to overweight range. Not a group of people with serious illnesses at all, they were just every day relatively healthy people, which makes the results even more interesting because we're looking at what fasting can do in a general healthy population.

This study was a randomized crossover trial. Instead of splitting people into two groups and comparing them separately, each participant got to try both approaches at different times. One phase where they ate normally and another phase where they did intermittent fasting. For the fasting phase, Mel, they used the classic 16-8 approach. For any new listeners out there, welcome, first of all. Secondly, that means 16 hours of fasting followed by an 8-hour eating window. It's one of those common fasting protocols, so relatively simple enough that people can realistically stick with it outside of a lab, which is why it's been used for this study.

The big question here was whether fasting couldn't actually change the way blood clots form. For me, this is quite close to home because of my vein situation that I had, so I was really interested in it. Clotting listeners or thrombosis, as doctors call it, is something we all need when we get a cut. Without clotting, we bleed out, but when clots form in the wrong place, for example, inside your blood vessels, they can block blood flow. That can cause stroke, heart attack, deep vein clot in your leg. That's the gnarly stuff.

Here's where it gets pretty fascinating. During the fasting phase, people's platelets, which are tiny, little, itty-bitty little cell fragments that trigger clotting, actually calmed down. They weren't as sticky, they weren't clumping together unnecessarily, and the overall clotting potential of the blood dropped. The researchers measured things like thrombone generation, which is a key marker of how your blood clots normally, and they saw its shift towards a much safer range. Even more impressive is the platelets themselves were healthier. The mitochondria, which is the little energy engines inside each cell, were working way better and oxidative stress, which is cellular wear and tear, was lower. Fasting wasn't just stopping these platelets from overreacting, it was really improving the health of the platelets themselves. This is super important because these benefits weren't just from weight loss or better blood sugar.

Barry Conrad
What the researchers saw was a direct effect of the fasting schedule itself on the biology of the blood. In other words, it's just changing when people ate. Just changing when people ate seemed to have a reprogramming effect on their platelets in a healthy way. Yeah, it's pretty relatively short, the study, and only in healthy adults, so we can't really say for sure what it would be for people who already have heart disease or whatnot.

These are lots of pretty powerful, they're pretty significant, and it suggests fasting could lower the risk of those silent but deadly events like heart attacks and strokes by literally calming your blood down. That's really exciting. Mel, once again, is showing that fasting is not just about the outside, it's what's happening deep down to the behavior of our blood cells. Pretty extraordinary. What do you think, Mel? Any thoughts on the study?

Melanie Avalon
Awesome. No, I think this is a incredible find.

And what I really like about it is I feel like we talk about and focus a lot on the endpoints of things affected by our blood. So things like, like you mentioned, like heart attacks, and just in general, like we focus on like specific organs or specific conditions, but we don't really talk about our blood that much, like as the thing to be addressed. And it's really interesting because there's actually, I don't know if you've heard of like the young blood transfusions things in the world of longevity. Have you heard of this?

Barry Conrad
Yeah, I have actually a little bit elaborate.

Melanie Avalon
Yeah, so basically, there's this idea that our blood is so key, like the health of our blood and the status of our blood is so key to our health and longevity that some people with a lot of money and the longevity sphere will even do like blood transfusions with younger people. Because they've seen when they do that in rats, that it makes the rats live longer. And I will say as a caveat, it's hard to know if it's the actual younger blood that's increasing the lifespan. Or is it just the dilution? Like is it that as we get older, our blood gets clots and the platelets aren't functioning correctly? And so just by diluting it, does that actually increase health biomarkers and such? The point is that was a little bit of a tangent. But the point is our blood is like the health of our blood is so, so important.

I don't think I've ever I don't think we've ever talked about it specifically on this show. So I'm so happy that you found this study. So I find it fascinating regardless. And then the fact that intermittent fasting has all those effects is incredible. That's like such a foundational change in the body. I love it. And you said the fasting window they did was what was the fasting window?

Barry Conrad
So not long at all.

Melanie Avalon
Yeah. So the type that, you know, a lot of people do, I mean, probably the most popular. Awesome. And this was a relatively new study, January 2025, or this year, at least.

Barry Conrad
Yeah, it's really exciting. And just like, yeah, we don't often talk about, we don't associate conversations about intermittent fasting with blood. So it was really refreshing to read as well.

Melanie Avalon
Yeah, I love it. Awesome. Awesome, awesome. Okay.

Well, we will put that link to that study in the show notes. Those will be at ifpodcast.com slash episode 446. And shall we jump into some listener questions?

Barry Conrad
Let's do it. Let's jump in.

Melanie Avalon
Okie dokie, would you like to read the question from Sharon?

Barry Conrad
I will. So Sharon sent in an email to us and that reads, Love your podcast. I await eagerly each week for a new podcast.

Lost 30 pounds since starting last August. My question is any research about using essential oils while in a fasted state. I love my essential oils, lemon slash peppermint oil in my water, et cetera. Just curious your thoughts on this. Thank you. Melanie, what do you think?

Melanie Avalon
Awesome, Sharon. Well, first of all, congrats so much on your weight loss. That's amazing. Yes, essential oils. So I love essential oils. Barry, do you use any essential oils, by the way?

Barry Conrad
I actually used to swear by Essential Oils that when I was doing Beautiful to Carole King musical, I used them a lot, but I just ran out of them and didn't buy any more. But they're awesome.

I love them.

Melanie Avalon
Which ones did you use?

Barry Conrad
I like peppermint. I like there's something called ice blue. What is ice blue?

Melanie Avalon
blue. Was it like a proprietary blend or something of oils?

Barry Conrad
Yeah, exactly.

Melanie Avalon
Yeah, that sounds so, so cool.

Barry Conrad
What did you use? Did you use any?

Melanie Avalon
Yeah, so I, well, peppermint I actually use to, I make my listeners probably know about this, but I make my breath freshening spray that I'm obsessed with. It's the best thing ever.

Have I told you about this, Barry?

Barry Conrad
I've heard you talk about this but I forgot about it so tell me how you make it.

Melanie Avalon
So basically friends, because people to like freshen their breath will do things like chew mints or chew gum. And I used to do all that all the time. And it's not usually like none of that is very fasting friendly, because you don't want to be full for gum, you don't want to be chewing because that's sending your body a signal that you would be eating. So I don't like that.

And then it's really hard to find mints, like I could never find mints that were not sweetened, even if it was sweetened with like stevia or something like that. But I don't like having the sweet taste during the fast because it like we talked about with clean fasting, like I think it, you know, can mess with insulin and with your cravings and your hunger. So my solution that I came up with was if you buy organic food grade peppermint oil on Amazon, and I can put a link in the show notes to what I buy, you buy that and then you buy these on Amazon, they also have these rainbow glass bottles that are like really, really small, they're spray bottles, you put a few drops of peppermint into that little bottle, add some water, close it, shake it up. And then you just like keep it with you and you just spray your breath and it is the most effective. Like, it just makes your breath feel so minty and fresh. And there's nothing problematic because it's literally just essential oil peppermint. It's so great. I highly recommend you'll get to see it when I meet you in person because I'm so obsessed with it that I will have like a, not a panic attack, but if I ever leave and if I'm going to a social event and realize I don't have it, I will probably turn back and go get it.

It's that important to me. So we will put links to all that in the show notes. So peppermint and then for like sleep, I use lavender essential oil every night. I love, I can never say it, ylang ylang. I really like that. I like sandalwood. My go-to, but to answer Sharon's question, so the go-to person that I love for anything essential oils is Dr. Eric Zielinski. I've been following him. Honestly, I have been following him. He's one of the OG people when I first started getting into the world of biohacking and health and wellness that I was following. And it's because I learned about essential oils and his book, he wrote The Healing Power of Central Oils, which is like one of the most, you know, well-known essential oil books out there. It's basically like the Bible of essential oils. I've had him on the show a few times and what's so amazing is he lives in Atlanta and we're like friends now. So I go out with, like me and my sister have had, we go out with him and his wife and they have, they have, is it seven kids now? I think it's wild. It's crazy. It's like Noah's Ark situation. In any case, I highly recommend listening to the episodes I've done with him checking out his books. The most recent time I had him on the show was in June of 2025.

Melanie Avalon
That was episode 305. And that was for, he made this really cool recipe book deck. It's just called Essential Oils Recipes. And it's a 52, 52 card deck. And friends, if you need, it will, A, if you want to make your own essential oil recipes, I highly recommend this deck. B, this is like an incredible present for people. Like it's so cute. It's so approachable.

And they have so many uses of essential oils, everything from, you know, sleep and relaxation to cleaning products that you can make to like massage oils to it's literally anything you could ever want to do with essential oils to actually answer Sharon's question about the fast. So her question is just taking them in a fasted state. Yeah. So, so basically there's different ways that people use essential oils. So if you're doing like a diffuser in your room, obviously that's fine. A lot of people put them onto their skin. And if you're taking it orally, they're all technically fine because they're not caloric. They're, yeah, I mean, I know it isn't oil, but I don't think it's, you're using such a tiny, you know, minute amount. So it's really more about the, like the flavor and taste and is it something that is going to feel like food to you. So if you were going to do like an orange essential oil, you know, or like a fruit related one, maybe not. But I think the majority of the ones that you would be using, it should be completely fine. Like she's saying lemon peppermint oil in her water. Oh yeah. Well, so, so lemon would be another one where it's like, you have to like figure out what works for you. So does that lemon flavor make you feel like you're having food? And do you feel like it's, you know, messing with your, your insulin or your fasted state? I would just be intuitive there. Peppermint, all the mints I think are totally fine. The fruits, like I said, like lemon, I would, I would just evaluate how you respond to it. If it's not affecting your hunger or your, your feeling of the fast, I wouldn't worry about it. What are your thoughts Barry?

Barry Conrad
It's a great question i think you answered it really well and i used to use peppermint as well in the shower if you ever tried the smell where you put a few drops on the floor and as soon as the hot water hits it just like you get this steam of peppermint that wakes you up so if i'm feeling tired it's really good.

Melanie Avalon
That's really cool. Yeah, because peppermint is great for alertness.

Barry Conrad
Yeah, and that would like be I'd have my coffee, my two coffees, two black coffees, and then I'd put a few drops in on the shower floor while drinking the coffee. And then by the time I start the shower, it just like wakes me all the way up.

It's so good. That's awesome.

Melanie Avalon
Yeah, so you can use them. It's great for like waking up and going to bed.

The lavender at night really really helps me with sleep And that I just rub into my skin. I'm gonna have to try your shower thing

Barry Conrad
And Sharon, consistency is the name of the game, as always. And if something small like using the essential oils is going to help you show up day after day, and it's not something that, as Melanie said, is going to remind you of food or bring on that response, then it's doing its job.

And it really does come down to how you feel, like Melanie said as well. If you're still seeing results, if your energy feels steady, if your fast is clean and you're enjoying it, then give it a shot. Let us know how you go and what, quote unquote, flavors or types you use. Thanks, Sharon.

Melanie Avalon
Awesome, awesome. Okay, should we jump into our next question?

Barry Conrad
Let's do it.

Melanie Avalon
So now we have a question from Michelle and this is from Facebook and Michelle says, this might be off topic, but are there any good natural supplements for depression? I get seasonal depression and I'm looking for a mood lifter, but I don't want to be on prescription meds.

Barry Conrad
Wow. Well, Michelle, first off, thank you so much for opening up and asking this question in particular. I know I can feel vulnerable and like you're putting yourself up there bringing something like seasonal depression up, but you're definitely not alone. And I know for me, I can sometimes feel that shift in mood when the seasons change. And when winter hits especially on those colder days when the days are shorter, my energy naturally dips personally. So the fact that you're looking for ways to manage it in a natural, thoughtful way is I really respect that.

So first off, I have to say again, I'm not a doctor, so I can't really give you medical advice. But if things feel heavy or too overwhelming, I always encourage talking to a professional e-trust. That said, I can say from experience as well and from conversations with people close to me to help keep spurts up, especially when the seasons mess with my mood, one thing that does help is a good old shot of vitamin D. We call it vitamin, sunshine vitamin for a reason. Naturally, our vitamin D levels can drop when there's not as much sunlight and that can really affect mood. And if something sounds really simple, but for people who have had their levels tested and found that supplementing even just a little bit can make a huge difference. And I try to get natural light in every day, even if it's just a short walk. I notice how much better I feel when I do that. And back here in New York, I'm making the most of it before it starts to get super cold. Another natural support could be omega-3 fatty acids, which is what you find in fish oil or algae oil. They're really great for overall brain health and some research suggests that they can play a pretty significant role in supporting your mood. I've tried them in the past, not a lot, but I have tried them, not specifically for depression, but more for general health. And I did feel like they kept me sharper and steadier. Then there's also movement. I know it's not necessarily a supplement per se, but honestly, regular exercise is one of the best natural supplements you could ever give yourself. Just moving your body and going for a walk. If you don't go to the gym, just moving your body, doing some stretches, even just doing that can get those endorphins flowing and make a world of difference to your mindset. If I skip just a few days of exercising, my mood takes a massive hit, definitely. And so I would say a combination of fasting and daily movement is something that's going to keep you really balanced and hopefully the suggestions of the vitamin D and the omega-3 fatty acids do help.

But Michelle, definitely want you to know that you're not alone in feeling that way as well. And there are ways to support yourself naturally. Start simple and then layer in those supplements thoughtfully if you feel like you need that extra support. And if things do get too hard, reaching out to your professional nearby is going to help. It's going to be one of the strongest moves you can make. So you're already showing resilience just by asking this question.

Barry Conrad
So be kind to yourself. Michelle, experiment with what feels good. And yeah, it's all about your well-being. You got this, Michelle. What do you reckon, Mel?

Melanie Avalon
Awesome. So I love everything that you said. And yes, thank you, Michelle, so much for your question. And so many people go through this and a lot of what I was going to say echoes what Barry said. The fact that it is the seasonal form does insinuate that it could largely be involved with the vitamin D like Barry was saying. So like he was saying, you know, getting sun exposure, you can use the – I actually haven't used it, but I've talked about it and I've heard about it a lot. There's the Dminder app and that actually shows you based on where you are located, when to best go outside and for how long to get the optimal vitamin D exposure – or vitamin D creation naturally from the sun. And then obviously there's the vitamin D supplements as well.

And then Barry was mentioning the fish oils and, you know, those just have so many incredible nutrients in them. And we actually can get some vitamin D from eating food like fish and things like that, too. And I will say just because you were saying, you know, that you're hesitant about taking the medication, I'm prepping for an interview right now. I haven't done it yet, but the author is Julia – I need to figure out how to say her name. I think it's Julia Hotz. And the book is called The Connection Cure. And it is absolute – it's a fascinating look at our – I guess our health issues today and how we have really dived into a pharmaceutical approach to treat them and how that's just not working so well. And how these other approaches, a lot of it involving connection, so connection to nature, connection to other people, connection to movement, how that has a radical effect on health conditions, including curing people's depression. And she talks in the end about – and people are probably pretty familiar with this, but the – relatively recently they have, when it comes to antidepressants, they've kind of – like meta-analyses and reviews of all the literature on antidepressants have shown that they aren't working the way we thought they were working, especially when it comes to things like serotonin reuptake inhibitors. And that oftentimes they're no better than placebo and or comparable to something like exercise. Or exercise can be even better than that without any negative side effects. I feel like the farther we go and the more we learn, the more the medications, which do work for some people. So I don't want to say that they don't work. I don't want to say that if you're anti-depressant works for you and it is bringing benefit to your life, by all means, keep on keeping on with that. At the same time, it seems like we've been way over-prescribed as a nation, and it's not necessarily always effective. And there are all these other approaches that really can radically help people's mental health and wellness. And so much of it isn't even supplements, which I can mention some other supplements which may help, but a lot of it is just foundational things.

Melanie Avalon
So your diet and your food and your lifestyle, a lot of people actually can have mental anxiety or depression coming from foods they're eating that aren't working for them, but for their personal body constitution and how their immune system might be reacting. Being sedentary, staying indoors, not getting exercise. Like I said, the studies on exercise as an anti-depressant are really, really fascinating and supportive. And then social connection, so, so huge. The loneliness has been shown to have extremely negative health effects, like shockingly so.

And in a lot of longevity studies, they actually find that social connections are one of the things most correlated to health and wellness, especially mental health and wellness. So Michelle, so a broad foundational approach, I'm saying there may be a lot of things that can help there. I know for me, cryotherapy, so cold exposure, there have been studies on that and how it releases feel good neurotransmitters like dopamine and norepinephrine, and that can actually last for quite a while. So the mood boost I get from a cryotherapy session is insane. Like if I go in not feeling so well, I go in for three minutes, I come out and I feel like really good. Same with cold, cold showers can do that, cold ice baths. And then going back to I said I would mention some actual supplements, some natural things you could experiment with like Rodeola, Rosea. Is it Rosea? I think so. I always just call it Rodeola. So that's an adaptogen. It's actually been shown to basically adaptogens the way they work is they help your body reach a state of homeostasis. So if it's like if you have anxiety, they help calm you down. If you're depressed, they help lift you up. So Rodeola is one in particular that has been shown to work well for low mood states. So that's something you could try.

I've tried that in the past. Lion's main mushroom has been shown to help with mood. Also, Sammy is probably the one that is most closest to, it's not a pharmaceutical, it's naturally occurring in the body, but it has a lot of studies on it for antidepressant like effects. But that is one that you do want to be careful with monitoring to make sure that you don't have a negative reaction or go too far. So another one is St. John's Wort. And that is also an herbal remedy. And it's been shown, it has a lot of research and evidence on it working for depression to the extent that in Germany, you actually have to get it by prescription, you can't buy it over the counter. But it is a herbal supplement. So that's something you could definitely try. But you do want to be careful because it can actually interact with other medications like SSRIs or birth control.

So be aware of that. And then in general, something I talk about the importance of magnesium all the time. Magnesium is just so crucial for overall whole body wellness. And in particular, you can get my Avalon X magnesium nightcap.

Melanie Avalon
That's a special type of magnesium called magnesium L3N8 that actually crosses the blood-brain barrier. So it gets magnesium into your brain. And there are a lot of studies on it to show how it can benefit mood, memory, rest, relaxation, all the things. So I would definitely get my magnesium nightcap and try that.

And if you want to get that, you can go to AvalonX.us and use the coupon code IFPodcast. And that will get you 10% off of that. Yeah, I'm just sending you Michelle, so much love and goodness. And I'm sure you can find things that work for you, make you help you feel better and all the things. Would you like to read the next one?

Barry Conrad
Sure. So Nydia on Facebook says, yes, I'm 51 years young. And is it good for me to fast 19 to 22 hours? The 23 hours is only when I get out of work late, but I fast every day except Sunday.

Is it good for my hormones? I recently have been gaining so much weight. Don't matter how many hours I fast. Melanie, what do you think of this question from Nydia?

Melanie Avalon
Yeah, Nydia, thank you so much for your question. And we get this question a lot, not this specific question, but a lot of people are curious about the age of a woman and when it is or is not appropriate to fast.

A lot of people seem to think that when you get older, that that's not, that fasting is more problematic. When the majority, like honestly, when I think back through people I've interviewed who are experts on fasting, thinking, for example, like, well, Cynthia, they're low, a former co-host here, or Dr. Mindy Peltz, quite a few other women, they're very pro-fasting for women as you get older, especially because you're no longer in this intense, like your fertility is, not that fasting negatively is gonna affect your fertility, but your body is not as sensitive to calorie deprivation and having a negative stress response. So a lot of women, especially like in menopause, find that fasting is a wonderful time to do it. The one thing that you definitely don't wanna pay attention to is that you're getting enough protein because the older that we get, the more protein we need, the harder it is for us to assimilate and break down protein just because of the aging process in general. So yes, and then when it comes to hormones, there's so much research and anecdotal evidence of people doing fasting and it helps regulate their hormones. So I would say definitely green light for fasting in your hormones at your age. I wouldn't be concerned about that as long as you're getting enough protein.

That said, your experience that you are gaining so much weight and it doesn't matter how many hours you fast, to me, that sounds like, it sounds like there's something to look at beyond the fasting that I think would be most effective here. So I wouldn't put all the focus on the fasting for the weight loss or stopping the weight gain. I would look at a broader picture of what is going on to make you gain the weight in the first place. So is it the eating choices? Is it changes in hormones from aging? Is it your sleep? Is your sleep off? Is it stress? Did you start taking a new medication? Like we were saying before, that can have an effect. So I would take a step back and relax into it and look at your dietary choices. What are you eating? Can you make any sort of changes there? If you're not eating a whole foods based diet, can you eat more whole foods? If you're not, basically there's a lot of options here. It's a good thing. If you aren't doing any sort of macro approach, so like a low carb or low fat, maybe that's something to try when it comes to the fast. It sounds like you're fasting, I mean, you're fasting a lot every day. So I don't know that there's that much that you can actually change there. I would go more with maybe looking at the food that you're eating within that window. Or you could try something like maybe ADF, where instead of fasting longer each day, you're not fasting every day.

Melanie Avalon
But then on some days, you're either fasting completely the entire day, or you're only having like a 500 calorie meal. There's a lot of things that you can definitely work with here.

But I would not, I do think, yes, it's good for your hormones. And I think there's a lot that you can look at for the weight gain issue. So including sleep, make sure you're getting your sleep. Barry, what are your thoughts?

Barry Conrad
No, Melanie, you answered that perfectly and so many of the things that you said or I was going to mention in not the hormonal situation, because I'm not an expert in female hormones, so I'm glad you addressed that, but I was definitely going to talk about maybe looking at food choices, because you are fasting so much, I pretty much fast around 20 hours every day as well. Like there's only so much fasting you can do each day, so Melanie's right, zooming out and seeing what other factors there could be.

Is it, are you stressed out? Are you sleeping enough? What are you eating? Because a lot of the times we think, not everyone, but some people can think, oh, I'm fasting so much, so it's going to be fine for me to have this extra insert, whatever kind of food you want. So those things do matter, they really do, even more than we realize, even sometimes we eat way more than we think that we're eating, we don't even know what's in the food, that could be something, maybe it's a medication, that's definitely something, are you taking medications? Everything that Melanie said, I completely echo, so we wish you the best and we really want to hear back what you found.

Is it the hormones? Is it the food? And report back to us, Nadia.

Melanie Avalon
Yeah, and it's kind of like the terminology, like when the focus, because, you know, she doesn't even mention what she's eating. And so the focus on like, no matter how long I fast, and like all the focus is on the fasting really says to me, like you said, like, zoom out.

And what beyond the fasting can we address here? And then you might find that the fasting just falls in line naturally.

Barry Conrad
Right. She does say here, but I fast every day except Sunday. So we don't know what's happening on that Sunday as well.

Melanie Avalon
Oh, good point. Yeah, I miss that. Yeah. So what also what's happening on Sunday?

Barry Conrad
Yeah, because it can be easy from personal experience before I started really dialing down on my nutrition, it can be easy to just blow out on like a day where you don't fast or whatnot. So it's important to realize that just because we're sort of front loading our fast during the week and not fasting on Sunday, it doesn't necessarily mean that it's a magic bullet just to sort of eat or drink whatever we want. Not saying that you do that, but it's just a point, something to keep in mind.

Melanie Avalon
Yeah. Actually, to that point, I'm not saying I don't know what Nydia's situation is, but like a situation, like hypothetical. Say you're in a situation where your food choices are not necessarily the most supportive of weight maintenance or weight loss. And then on top of that, maybe you're not sleeping well, and then stress, all the things, and you're fasting. So basically, maybe that alone would be maintaining you, but then you have this blowout day where it's all the things. Now the scale is tipped towards weight gain, because the rest of the days, you're just kind of getting by with maintaining. And I'm not saying at all that that's the situation. That's just a situation that could apply to somebody.

Barry Conrad
Cause another thing Melanie is, is like, you know, especially with females, well, a lot of females I've met as well, they find it hard to kind of get everything in, like if she's, if Nydia is eating fasting for 19 to 22 hours a day, sometimes 23, that's like a couple hours to eat. And most people, no, I'm not going to say most, a lot of people find it hard to eat massive volume like you and I can, especially in a short time.

So if just as a scenario, taking Nydia aside, if someone were to just eat all day on a Sunday, they have more room to eat more incrementally throughout the day, but a lot more rather than just being unable to eat on those fasting days. You know what I mean?

Melanie Avalon
Yes, exactly. So there's just so many potential factors here. So I think taking a breath, stepping back, looking at the bigger picture, and then reevaluating.

Barry Conrad
Let us know, Nydia.

Melanie Avalon
Awesome. Okay, shall we have our proverbial breaking of the fast moment?

Barry Conrad
I'm so excited for this moment. Let's do it.

Melanie Avalon
Me too. We haven't done this in forever.

Okay. Okay. So I have today's restaurant. I've been collecting berry while we haven't been recording. I've been collecting a lot of restaurants. Really? Yeah. Yeah. So I'm excited about these. So this one, here, I'll tell you about it a little bit first and then I'll send you the link. So it is a, it's in Mansfield, Ohio, and it is a Civil War era beer cavern.

Barry Conrad
Thank you for watching.

Melanie Avalon
It's called Prohibition at the Caverns. It's 30 feet beneath Hudson and Essex, which is the city's fine dining spot upstairs. And they found it by accident. So they were conducting renovations of the building above, and they found a hidden sandstone chamber beneath. And apparently, there have been legends of tunnels under Mansfield for years.

And then they found them. And so the history of it is this is from the mid 1800s. And it's when thousands of Germans fled political unrest and went to all these different cities in the US. And they brought beer with them. And they started brewing all this beer. And it led to, especially during the Prohibition movement, these secret breweries underground. So they probably were dug in the 1860s. Let's see. And so the way it works, though, so you can't just walk in, you have to have reservations. They do four courses on Friday nights, eight on Saturdays. And the way it works is you start upstairs at the restaurant, you take an elevator down. And then let's see, there's warm, soft candles. And it's in these caverns, the menu is seasonal. And you can have wine pairings. And then they also on Thursday nights, they do a dinner movie series where they make the menu be themed to different movies like Casablanca or Pulp Fiction or Ratatouille. So was that fun?

Barry Conrad
This place sounds awesome.

Melanie Avalon
Yes, let me send you the menu. Should we do the dinner in a movie menu or the normal menu?

Barry Conrad
Dinner in a movie kind of sounds like a moment, let's do that.

Melanie Avalon
Let's see if they show CR a full movie calendar. What are they doing right now? Does it say what movie it is?

Barry Conrad
Yes, I clicked on the see our full movie calendar and it has different things in different dates, like there's American Psycho, there's It, there's The Lost Boys, there's Friday the 13th, I guess because of Halloween, I'm guessing it's the scary, yeah.

Melanie Avalon
I guess they don't have the menu, though, for what the actual movies are. I mean, they have a menu, but it's not. Let me look at their normal menu. Yeah, let's go back.

Barry Conrad
the normal ones, see what they got. I love this idea. I think it's...

Melanie Avalon
Go ahead. Maybe we can do the normal one since there's more choices. Should we do eight course or four course, eight course, right? Let's do eight course.

Always. OK, so this is the Saturday night eight course menu. Oh, wow. You either get it with or without wine pairings. See, here's the problem, Barry. I would obviously love doing wine pairings, but I'm so specific in what I drink that I would rather just pick out my own wine.

Barry Conrad
I was about to say that I was like, we could do one appearance, but I don't think that's really a Melanie Evelyn situation because you want to choose it.

Melanie Avalon
Yeah, so maybe no wine pairings. So first course, Breaking Bread, Vegetable Cracker, Cherlo, French Butter, Peach, Saffron Jelly. Would you like that, Barry? You can have my bread.

Barry Conrad
Yeah, I love a good bread, especially if it's fresh. I always try it.

Melanie Avalon
Okay, so Barry will take over that course. And then, homage to an homage to an egg, that's a cool title.

Barry Conrad
It is.

Melanie Avalon
Crab and artichoke brulee with caviar and Prosecco.

Barry Conrad
That sounds good.

Melanie Avalon
I would have the I'll tell you how I'll tell you what I'll have from this. I'll have the caviar part of the caviar.

Barry Conrad
you'll take it off like wherever it's served, like you'll pick, you know, take it off.

Melanie Avalon
Yeah, I'll have like a like a like I'll like pick one up and then you can tell me how the rest is. So then we have trying to figure out menus hard to read.

Do we pick from the next? Okay, no, no, we just I guess it's all the same. So then do you want to do you want to read the next course La Milpa?

Barry Conrad
The next one is called La Milpa. It's corn chowder zoodles. Is that zucchini noodles?

Melanie Avalon
Yes.

Barry Conrad
corn chowder, zoodles, salsa verde, cotija, lime, cilantro oil, and chili. And then it has French colambard.

Melanie Avalon
I just realized maybe we should run the movie one cause I think you can pick your entree. You can. I think so.

Wait, cause here the main, so the main entree here is tuna, I think, and then confit duck leg. Wait, let me see. Let's look at the dinner in a movie.

Barry Conrad
Let's see the best situation for our tastes.

Melanie Avalon
Dinner, oh wait, dinner and a movie, okay, well, you can't win because dinner and a movie you can pick, but I actually don't want any of that.

So maybe we can go back to the, back to the A course. Okay, wait, hold on, I keep losing it.

Barry Conrad
So we just did the La Milpa, and the next one is, what do we have there, Mel? It's, I like the names, Air to the Ground.

Melanie Avalon
Wait, I like the four-course menu. I am all over the place here. Four-course menu, they have for the third course, you can pick a filet mignon.

Barry Conrad
Okay. Do you want to switch to that one? Do you want to switch to the full horse? Yeah. Okay. We're switching. We're officially changing our minds.

Melanie Avalon
We have now come to this restaurant three different times. Three different times.

Okay, we're starting over. We're going on a Friday, guys. Four courses. Okay, starting over. First course, what would you like?

Barry Conrad
First course. Wow, okay, I'm gonna go for the lobster roll. Lobster roll, kyupai mayo, shallots, herb, green onion, roll, kyewertsraminer. Got that completely wrong, but just go with it.

Melanie Avalon
That's the recommended wine pairing. Oh, it is? Yeah. I'm going to go with it. Okay. I will have, can I have a piece of the lobster from the roll? You can have a piece.

Barry Conrad
Yes, you can.

Melanie Avalon
like a tiny little piece of lobster.

Barry Conrad
Yes. Oh, Melanie is a side note, but not really a side note. When I was in Melbourne just before coming back, the hotel I stayed at, they do this incredible lobster roll. It was so good.

So I do love lobster rolls. Do you like them? I like lobster. Not their whole so much.

Melanie Avalon
Which, oh wait, speaking of, didn't you go to one of our restaurants?

Barry Conrad
Melanie I went to Gimlet. Yeah. I went to Gimlet and it exceeded expectations. Yeah, it was delicious.

It's the first time ever that I've actually tested a restaurant in the wild like after we've talked about it. And it was such an awesome feeling as well. It's like, hey, we talked about this restaurant. The ambience is amazing. The food was 20 out of 10. Really delicious, tasty, incredible.

Melanie Avalon
Oh my goodness. And did you remember the menu at all?

Barry Conrad
I tried to remember, but I don't really know. I did have the oysters though. I remember that much.

Melanie Avalon
That's another thing I've been saving while we haven't been recording. I think I have like 10 different articles about oysters because every time an oyster article comes up, I'm like, I'm going to share this with Barry. And now I literally have like 10 of them.

Barry Conrad
Better not be anything that debunks the amazing joy that oysters bring to my life.

Melanie Avalon
One of them I really liked, the person hated oysters. I was like, this is a great article.

Barry Conrad
That person's terrible.

Melanie Avalon
know, it's like random things like this is the best oyster place. I don't know. It's just like random oyster articles. Okay, awesome choice. Yeah, I'm so excited that you went there. That's so exciting.

So okay, I would get I'm gonna get the galette. Is that how you say it? We're always butchering names. So it's a salad. I'm just gonna eat the prosciutto off of it. It's prosciutto, peaches, ricotta, thyme, rosemary, arugula. I'm gonna eat all the prosciutto prosciutto.

Barry Conrad
Can I have the rest of your things?

Melanie Avalon
What if I asked, okay, yes, nevermind. I was gonna say, what if I asked them, can I get this salad with just prosciutto, like only prosciutto?

No salad, just prosciutto. Then they'll bring me like, what if I did that?

Barry Conrad
What about the irregular salad or the rosemary? You don't like that? There's like a little garnish on the side of the plate or something.

Melanie Avalon
Actually, it's so funny story. I actually do like salad. It doesn't always as my mom says I like it It doesn't always like me. I actually don't like arugula though

Barry Conrad
You don't? Mm-mm. I've only started eating more of that since coming to America, funnily enough. And so far, so far, I'm like nothing to write on about yet, but it's not bad, it's just don't love it.

Melanie Avalon
Yeah, I don't like... No, I don't like the... It's got that... It's got like a negative... Okay, the lettuce I like. I obviously... Well, iceberg is fun because it's like water with like a like a crunch to it and a little bit of freshness.

It's like green water, pretty much. Yeah, I used to... Instead of eating... I don't know if you knew this, you might have known this. Instead of my cucumber fixation, it used to be lettuce. I would eat like... Because, you know, I like to like eat my cucumbers while drinking my wine and everything and then add it to my meat as kind of like a digestible, like hydrating substance to add to the meat. I used to do that with heads of lettuce. Like I would eat like... I'm not kidding, like four heads of lettuce.

Barry Conrad
That's a lot of, but it's very hydrating though.

Melanie Avalon
So hydrating, I know. So I love lettuce and romaine. Everything else, not so much.

Barry Conrad
I like to have with iceberg lettuce, like a bundler's burgers, if I make them at home, like, that's good.

Melanie Avalon
That is good. Yeah. Okay. Yeah.

So I'm just going to get prosciutto. Oh, no, no, no. I'm getting the whole thing so you can have the rest and I'll eat the prosciutto. Okay. Second course. Second course.

Barry Conrad
What are you feeling? What's looking good?

Melanie Avalon
So the scallop, arancini, what does that mean?

Barry Conrad
I knew you were going to go to the UN straight there.

Melanie Avalon
But what is that? Can I just get scallops? We'll see. Scallops.

Barry Conrad
Because arancini, if it's what we call it in Australia, they're little balls. You know those things? Like little balls? Like an arancini?

Melanie Avalon
Oh, yeah, it is. I looked it up. OK, so I'm going to see, they're going to hate me here. I'm going to be like, can I, can you just get like some scallops?

Barry Conrad
What if the same we can't do that in the ball so.

Melanie Avalon
It has to be in the ball. I'd be like, wait, so it's pre-made? Is that what you're telling me? No, I wouldn't, I wouldn't be snarky.

If they said no, then I'd be like, well, you can, what does Barry want? Barry, you can have mine.

Barry Conrad
Not the cannot the house solid because that to me doesn't seem festive the corn chowder i'm curious about but corn chowder like a like a seafood chowder. I probably get if i had to use a property this color and she and the corn chowder is a second.

Melanie Avalon
Okay, perfect. So, okay, and then third course, this is why we switched menus three times. I know what I'm getting.

What are you gonna get? Oh, and I'm really curious if you were gonna get, okay, well, I'm getting the filet mignon.

Barry Conrad
That's exactly what I was going to get.

Melanie Avalon
Okay, perfect. Yes. How are you getting it cooked?

Barry Conrad
I know you're asking this with a judgmental tinge in your voice. How are you doing? Is it going to be medium or done? No, it's going to be medium.

Melanie Avalon
I accept everybody.

Barry Conrad
It's medium rare, but I always say more on the medium, more on the rare side of medium rare.

Melanie Avalon
See, Barry, that's like, that's probably the most right answer, if there's like a right answer. So no judgment.

That's like the correct answer. Like you, you like scored on the fine dining correct answer.

Barry Conrad
And I said that, and I do remember, I promise I do actually remember saying that at Gimlet. Medium rare, please, but on the rare side of medium rare.

Melanie Avalon
And did it come out on the rare side of medium rare?

Barry Conrad
Absolutely. And they were really happy with that request. Like, oh, of course.

Melanie Avalon
Nice. You know what technically the rare side of medium rare is if you're technically using the correct restaurant speak? Oh, wow. No, do you know what it is? Like what you would say? You would say rare plus. Don't say it though because servers hate it.

Why? Because technically that's the correct terminology. So it's like rare, rare plus, medium rare, medium rare plus, medium, medium plus, medium well, and then well. I don't think there's a medium well plus. I think it just goes from medium well to well. But when people use the pluses, you're like, Oh, man, because you're like, it's one of these people.

Barry Conrad
Oh, okay. It's like has a competition. Oh, they're gonna be really they're gonna be like a nightmare to you know

Melanie Avalon
Yeah, so it's correct, but don't use it.

Barry Conrad
Okay, how about I'll use it only if, like, all my other courses preceding this course. We've had a good banter, it's been really friendly, and I'll be like, oh, I'll get Rare Plus, and then I'll be, oh, great.

Melanie Avalon
Yeah, if you've established yourself, although if you're with me, I'm really very pleased with

Barry Conrad
on the side of a rear, please.

Melanie Avalon
So it comes with pesto, cannellini, beans, parmesan, red wine vinegar, and parsley. Would you get it that way it comes?

Barry Conrad
Yeah, I reckon I get it the way it comes because I'm assuming it's not going to be all drowning in that. Hopefully, it's going to be on the side a little bit, but I'll try all of that.

Melanie Avalon
Awesome. And I'll have mine completely plain. Salt and pepper, at least. No.

Barry Conrad
No. No. Okay. Why am I surprised? I know that. You like to have a plan.

Melanie Avalon
Nothing, nothing, nothing, and as blue as they will bring it.

Barry Conrad
on the rare side of rare, on the rare, not even a plus, like minus.

Melanie Avalon
Awesome. And then fourth course. Oh, wait, can I guess what you want?

Barry Conrad
Yes, and you're probably going to get it.

Melanie Avalon
I think you want the Black Forest cream puff.

Barry Conrad
I do and also I know that you're not going to order from this section so I'll get the other one too.

Melanie Avalon
Perfect. Do you want to read them?

Barry Conrad
So at the Black Forest cream puff is a pate a show dark chocolate cream, red one poached cherries. Yum, mascarpone, whip, cherry color reduction with some port over born. The milly fugly is the second dessert and that's spiced cream, crispy filler, lemon curd, love lemon curd, strawberry curd, pistachios, lemon peel, port or bourbon. This actually sounds really refreshing.

So I'd first have the chocolate and then finish with the citrusy deliciousness that sounds great. Awesome. What a find. Thanks, Mel.

Melanie Avalon
You're welcome. And then I would get like drinks wise, I would find a organic European lower alcohol wine, because I don't see a drink menu on here.

Barry Conrad
Yeah, I don't see it. I'm having a look. I don't see, but I'm sure that they will gladly.

Melanie Avalon
Out of the pairings that I see, they have a cab fronk, so I know I would... Ooh, and a cabernet rosé. I've recently gotten more into rosés and orange wines.

Barry Conrad
We've talked about this before. Do we talk about orange wine before the show?

Melanie Avalon
I think we talked about it on the show or offline. We're talking about the stereotypes of drinking Rosé.

Barry Conrad
We did. And I actually, in Melbourne, I drank a lot more, guess what, a lot more rosé than Pinot Grigio in Melbourne. Oh, really? Yes, after our conversation.

Melanie Avalon
I love Rose. What I was saying about the stereotype was that for some reason, well, I guess because it's pink, I don't know, people associate like girls and women drinking Rose, like it's like a quote girly thing to do.

But if you think about it, like they think it's more girly than a white, but technically Rose is more skin exposure. So it's closer to a red. So if you're going to look at it as like a red wine is masculine thing, then technically Rose would be more masculine than a white wine. I'm just saying.

Barry Conrad
You're right. And also, yeah, got over the complex. And also, dry rosé is actually pretty low-calve too. It's pretty good.

Not by much, but in comparison to Pinot Grigio. So I smashed the rosé in Melbourne. And also, orange wine's delicious. What made you want to get into that?

Melanie Avalon
actually a few different things. Well, actually, so it depends for any wine. I feel like it depends on the wine, but I had one that my friend got me for a birthday present and then I found this company called Bliss Wine Concierge online because I was looking for a specific wine that I love that's organic that I used to get from dry farm wines. They didn't have it anymore.

I could only find it from this Bliss place and they have a lot of other really amazing wines and they have some incredible oranges that I have become obsessed with. And he has a lot of, his name is Andre. He's amazing and he has a lot of really, he sources a lot of organic low alcohol, whites, rosés, oranges, and some reds. So listeners check it out. The website for that is, I've been posting about it on my Instagram a lot. It's blisswineconcierge.com. I highly recommend it.

All right. Well, this was so, so fun. Oh my goodness. It was so good to catch up.

Barry Conrad
I know, so great.

Melanie Avalon
And I'm really excited for next week. I have a really fun study to talk about. I can't wait.

So awesome. Well, listeners, friends, these show notes for today's episode will be at ifpodcast.com slash episode 446. You can get all of these stuff that we like at ifpodcast.com slash stuff we like. You can submit your own questions by emailing questions at ifpodcast.com or you can go to ifpodcast.com and you can submit questions there and you can follow us on Instagram. We are ifpodcast. I am Melanie Avalon. Barry is Barry underscore Conrad. I think that's all the things.

Anything from you, Barry, before we go?

Barry Conrad
That's all the things. Thank you so much for tuning in again, all of you amazing listeners, and we will see you and talk to you next time, I should say.

Melanie Avalon
Awesome! I will talk to you next week!

Barry Conrad
See you next week, bye!

Melanie Avalon
Hi! Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed.

If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by podcast doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

See you next week!

Oct 27

#445 – Special Guest Dr. Chris Rhodes, Mimicking 36 Hour Fasts (Without Fasting!), Fasting Metabolites, Making Fasting Easier With Mimio, OEA, PEA, Nicotinamide, Spermidine, Appetite Suppression, ADF, Lifespan Extension Studies, And More!

Intermittent Fasting

Welcome to Special Guest Episode 445 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, biohacker, founder of AvalonX, and author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine, and Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC


Dr. Chris Rhodes is a PhD in Nutritional Biochemistry from UC Davis, and an expert in nutrition, biohacking, and longevity. He has spent the last 8 years of his research career unraveling the mysteries behind intermittent fasting and its incredible ability to optimize health and extend lifespan. During his clinical research into prolonged fasting, Dr. Rhodes uncovered that a 36 hour fast was able to greatly enhance the biological function of the human body, taking already young healthy people and optimizing their cellular performance, recovery, and protective systems. Dr. Rhodes discovered that these effects were due to a unique set of molecules that are produced in the body only during long periods of fasting and that these “fasting metabolites” could be used to recreate the beneficial effects of fasting without actually needing to fast. To share this breakthrough with the world, Dr. Rhodes co-founded Mimio Health, a biotech company creating first-of-their-kind biomimetic supplements designed from human biology to optimize health, slow aging, and enhance longevity.


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BiOptimizers’ Probiotic Breakthrough, featuring the patented P3OM strain, is a single-strain, stress-hardened probiotic designed to survive stomach acid and support gut health. It’s proteolytic, helping break down protein and improve overall nutrient absorption, while promoting a balanced gut microbiota. This plant-based, vegan-friendly, and travel-ready supplement multiplies in the gut for powerful effects without refrigeration. Get 15% off with code IFPODCAST15 at bioptimizers.com/ifpodcast.

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Original theme composed by Leland Cox, and recomposed by Steve Saunders.


Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.


TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)



 
Melanie Avalon
Welcome to episode 445 of the intermittent fasting podcast. If you want to burn fat, gain energy and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you.

I'm Melanie Avalon, biohacker, founder of Avalon X and author of What, When, Wine. Lose weight and feel great with paleo style meals, intermittent fasting and wine. And I'm joined by my co-hosts, Barry Conrad. Actor, singer, songwriter, and creator and host of Banter with BC. For more on us, check out Melanie Avalon.com and BarryConradOfficial.com. You can submit questions for the show by emailing questions at I have podcast.com or by going to I have podcast.com. We would love to hear from you. Please remember the thoughts and opinions on this show do not constitute medical advice or treatment. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine. If it's that time and get ready for the intermittent fasting podcast. Hi everybody and welcome. This is episode number 445 of the intermittent fasting podcast. I'm Melanie Avalon and I am here today with a very special guest. It is a repeat guest. That's how you know we love these people. So I am here today with Dr. Chris Rhodes. He is the founder of an incredible company called Mimeo that we have had him on the show before actually episode, I was just saying this episode 379, so quite a while ago. And Chris and I met, we met through email right before meeting in person.

Dr. Chris Rhodes
Yeah, absolutely. Yeah, I think we actually met through Vanessa Spina on the Yeah, the keto girl podcast.

Melanie Avalon
Yes, yes, yes, that's right. So former IF podcast co-host Vanessa, that's right. Yes, we all met that way. And I was immediately overwhelmingly fascinated with what Chris does with Mimeo because they actually, and we're going to talk about this on the show, but they make a fasting mimicking supplement, essentially a supplement that you can take that creates biomarkers in your body that mimic the fasted state. And this science is just so incredibly cool.

And we were just talking before this, Chris, they are always doing really incredible research surrounding the supplement. So in today's episode, we're going to revisit that we're going to talk about what it does, how it can benefit you, how it compares to fasting, how it can potentially supercharge your fasting. And we're also going to dive into all the newest updates. I know so I'm now I am now seeing Chris at two biohacking conferences in real life in person. And he was really excited to see me. Well, that feels so that sounds so pretty just.

Dr. Chris Rhodes
I was, I definitely was.

Melanie Avalon
I was going to say you were excited to see me to tell me about a new formulation that you were working on. So there's just a lot of really, really cool stuff here.

So Chris, it's always a pleasure to talk to you, dive deep into all these things, and thank you so much for being here.

Dr. Chris Rhodes
Yeah, absolutely. Thank you so much for having me back.

I am really excited to be here. I am really excited to talk to you as always. We've got some fun new stuff to share and just totally ready to dive in.

Melanie Avalon
I am too. And I actually pulled out all my notes from our last episode. And I think it was long enough ago that we can make the assumption. We're going to make the assumption that people have not heard that episode rather than just reference it perpetually.

So to start things off, can you recap your story of how you came to be in this field? Because it is such a specific supplement. And I'm thinking in my head, I don't know that anybody else is doing is anybody else doing anything like this?

Dr. Chris Rhodes
No, no, we are 100% the only biomimetic supplement company. So really taking the time to look at human biology in these interesting regenerative states, whether that's fasting or exercise or sleep or meditation and really decoding what's happening in the body during these interesting times and figuring out ways that we can recreate those benefits on demand. And that's really what Mimeo is all about.

So Mimeo itself is a combination between mimic and biology together. So that kind of gets at our underlying biomimetic research approach.

Melanie Avalon
Is there a difference between the body manifesting these different states being created from you doing something to create that state endogenously versus just taking something that mimics that state? Like, how do we know if that's the same or different?

Dr. Chris Rhodes
for sure. Yeah. So there's definitely going to be some differences.

So kind of like to orient people who have not been, you know, listening to the podcast where we didn't hear the other episode before Mimeo basically mimics the same things that happened in the body during a fast. And how we know that is that we did seven years of clinical research, looking at what happens in the body during a 36 hour fast. And basically what we found there was that when people fast for 36 hours, there's this unique set of molecules that are produced by the body that are really only elevated during a fast. And we found that those were the ones responsible for activating a lot of these cellular health and longevity benefits of fasting, whether that was, you know, creating anti-inflammatory effects or antioxidant effects or promoting autophagy, what have you. So we basically just took those molecules, put them into a daily supplement so that you can take it. And this recreates fasting at the molecular level, uses those same molecules that your body would naturally produce to activate those same beneficial fasting pathways and create these same cellular and longevity health effects, but without actually having to fast at all.

Melanie Avalon
And so to that point, because I asked for the audience for questions about fasting mimetics and Marissa had a really good question. She said, if you fast daily with just black coffee and plain water with a typical window of 20 to 24 hours, do you really need these?

And then she added, I do take your Sarah peptase in my fasted state. But so basically, if somebody is fasting anyways, potentially experiencing these states anyways, what is the benefit of adding this to that?

Dr. Chris Rhodes
Yeah, absolutely. It's a great question. So this is basically kind of a jump start to a lot of the fasting that people would ordinarily be doing. So, you know, most people are doing the 16.8 style. The question was about 24, 20 hours of fasting. So Mimeo was designed to mimic a 36 hour fast, which is a, you know, a portion of fasting that people don't normally approach all that often. Right. So we found that the molecules that are elevated during a 36 hour fast are very uniquely elevated during a 36 hour fast. So you're not really going to experience the elevation of these metabolites. Your body isn't going to be making them ordinarily during these shorter term fasting windows of like 16 hours or 20 hours or 24 hours. So if you are already fasting, then these can be a great way to kind of supercharge your benefits and get the benefits of longer term fasting that you might not otherwise experience during these shorter fasting states.

And the great part about Mimeo is that because of the molecules that we actually identified, they have their own unique effects and benefits as well that can actually help to make fasting itself easier. So one of the molecules that we identified was ole oil, ethanolamide OEA, and that's involved in the gut brain access helps to stimulate satiety, reduce hunger. So that molecule can really help to make fasting easier because it has appetite suppression effects and it has P part alpha activity, which basically means that it can help your cells themselves switch over from carbohydrate metabolism, which you would normally be running in a typical fed state to beta oxidation, ketone production, fatty acid, utilization that you would experience during fasting. So it can really help to just get your cells in this more deeper state of fasting while still in a shorter fasting window. But we have also identified that this formulation, the Mimeo formulation can recreate the benefits of fasting, even when you are eating. So we've done three clinical studies that have basically shown that we can get these fasting-like benefits even when people are eating. So if you're a normal faster, but let's say you're going off of it for whatever reason, right? Like you are just taking a break, you have a day where you're not fasting, Mimeo can really help to keep you on track, give you those benefits of fasting, even when you're not.

Melanie Avalon
Yeah, this is so cool and it's really exciting for me because I think people might think, given how much I talk about fasting for, I mean, approaching a decade now and have been doing it for over a decade, that I would regularly engage in fasts that are, you know, longer than 24 hours. I really don't, like it's, and it's not easy for me.

And the reason it's not easy is it actually might not be what some people think because some people might think I would find it difficult going longer, but it's not an appetite thing for me. Like I'm not, I don't have any issue feeling hungry at the end of my fast. It's just the sleep piece. Like I can't sleep on an empty stomach. So because the days are not 36 hours, I find it really difficult to fast longer because I just need to eat before I go to bed. So this is really incredible because it sounds like it's a way for me to achieve those benefits that I would like to get in a longer fast while still getting to not go to bed on an empty stomach.

Dr. Chris Rhodes
Yeah, that is exactly right. And that's what we've proven out in those three clinical studies that I mentioned before in all of them.

People have just been taking Mimeo eating normally and not altering their diet or lifestyle at all. And we can still achieve those fasting like benefits, which is really, really interesting. And kind of, again, speaks to that underlying biometric approach that we're doing really taking what your body would naturally do during a fast and then just giving it back to you on demand.

Melanie Avalon
So in my use case scenario or somebody who's doing a one meal a day, for example, like say, let's say they're eating dinner, when would you take it to get the effects? So would it matter if I take it during my fast during the day? If I take it with food at night? And like, when does the timeline start?

How long does it last? What's happening there?

Dr. Chris Rhodes
So actually, the way that you use it is, I think, very similar to the way that I use it. So I'm also on a one meal a day schedule. And that is an artifact of back when I was originally doing the foundational research for Mimeo. I was doing experimentation on myself, on my own cells. I did a 72 hour fast and basically was taking my blood, looking at my cells every few hours throughout that time course. And what we found there was that when people and when I fast for 36 hours or longer, there's this really profound effect on cellular functionality that happens. So cells become more resistant to stress, they become less inflammatory, they become more antioxidant, they have better metabolic flexibility, they become more cardio protective, all of these really amazing things. And when you look at that as a young kid, like I was when I was first seeing this, I was like, wow, something that I did actually affected me. And it made my cells so much healthier, even though I was already a young healthy guy to begin with. So I got very into the fasting lifestyle.

I was like, I can do something, I can make a change, I can actually improve my health, I can turn my ordinary healthy cells into basically super cells. That's so cool. So I got really into that lifestyle, started doing alternate day fasting and stuck with that for about two years. But there's an interesting element of social isolation that comes along with that, right? Because so much of our society is about bonding over food. So you're not, you know, having lunch with co workers or dinner with family and friends. And if you are having, you know, those meals with those people, then you're like, okay, cool, I'll just, you know, watch you eat while I just sit here and stare at you and drink water, right? And like, no one's about that. And so my sister eventually told me like, you know, Chris, you are gonna live longer, that's gonna be very cool. But like, what's the point of living longer if you have to live less? And that really struck a chord with me. So I ended up modifying from like an alternate day fasting schedule to more of a one meal a day schedule. But how I supplement with that is I take Mimeo in the morning, that gives me the appetite suppression effects that gives me the like the kind of cognition and energy impacts that I really want out of the day. I'll finish my work day out, go to the gym, work out in a fasted state, and then have my big, you know, one meal of the day kind of like as a reward situation really help promote the pro growth, pro protein, pro muscle incorporation pathways in the body with that meal. And that's just my day to day schedule now. And I find that that works so much better just to exist in society with the fasting lifestyle.

Melanie Avalon
This is so cool. So when you were doing the ADF, you were doing like eating nothing one day and then eating regularly the other day.

Dr. Chris Rhodes
Yep, that's exactly right.

Melanie Avalon
Yeah. Oh my goodness. Could you sleep on an empty stomach when you were doing that?

Dr. Chris Rhodes
Yeah, I could.

It was definitely hard to adapt at first.

I would say that it took me probably around two weeks.

And it's very jarring, you know, the first time you do it, because I think that we have this mental preoccupation with food that's kind of been ingrained in us since we were kids just in American society, right?

It's like you have to eat three meals a day, like plus snacks, you should never ever be hungry.

And if you are hungry, that means something's going horribly wrong, like your body's eating itself, like you're starving, right?

And then you kind of have to break through that mental barrier of like, Oh, no, it's fine to be hungry.

It's fine to go to sleep hungry.

But there were definitely times when I was first doing it where I was very, very convinced, especially when I was like on a 48 hour fast, trying to go to bed on a 48 hour fast, there's just something I don't know, primal in your body that was like, if you go to sleep, you will die, you will never wake up, you know, that kind of thing.

And like once once you get through that, it's very empowering, because you kind of have this sense of Oh, wow.

Yeah.

If, you know, I just don't have to be eating all the time, if something pops up, and I don't want to eat it, I don't have to like I can go 48 hours without eating and be totally fine.

So there's a certain amount of freedom that comes with that.

Melanie Avalon
Yeah, I could not agree more. And still, I don't know. I don't know if I would ever adapt to the sleeping aspect of it.

Yeah, I think I did in total, maybe like three or four times I did a 36 to 48 hour fast and never really was not my cup of tea question because you mentioned the OEA. And didn't you test like over 300, like over 370 different molecules to find the four?

Dr. Chris Rhodes
That's correct. Yeah.

So when we looked at what the differences were between a baseline state and a 36 hour fasted state, we did find over 300 metabolites that were significantly different between those two states. So like 300 metabolites that were uniquely upregulated during fasting. And those were the ones that we screened through to see which could kind of mimic those beneficial cellular effects. And we ended up finding that combination of four of them that eventually became the Mimeo formulation.

Melanie Avalon
And I get just a little bit overwhelmed thinking about all of the potential, I forget the math terminology, permutations, whatever the word is for all the potential combinations of things there. How did you, and this was presumably before today's current AI, how did you like figure out that combination of four? I'm just overwhelmed by those numbers.

Dr. Chris Rhodes
Oh, I know. Yeah, it is a very overwhelming set of numbers. And yes, unfortunately, this was really before the advent of AI. So I was just, you know, a struggling grad student at the time being like, well, I have this list of 300 molecules, best get to researching. So that's exactly what I did.

I just I took that list of 300. And I looked at all of them through pub med, which is, you know, where you can find all of the scientific literature that's ever been published. And we were able to identify from that list of 300 around a two dozen or so that already had some kind of scientific literature behind them of having what we call bioactivity. So these molecules can actually impact cellular functionality, whether that's creating these anti inflammatory effects, these antioxidant effects, these autophasic effects. So from that list of, you know, two dozen or so, we then started screening through the individual molecules on these cellular assays that we have just looking at what the individual molecules themselves did to cellular functionality. And that's where we found, you know, these four different molecules that could, in some way or another, recreate the benefits of fasting. And then when we combine them together, could basically recreate all of the cellular effects that we were seeing through fasting. So that included creating those anti inflammatory effects, creating those antioxidant effects, creating those cardio protective effects, those cellular protective effects, those metabolic flexibility impacts. And really significantly, when we combine those four molecules together, we were also really interested in how this affected longevity and lifespan. So we did an experiment looking at how the four molecules together impacted longevity in C. elegans and found that we could increase their lifespan by 96% just through supplementation. So doubling their lifespan, but without any kind of fasting without any kind of caloric restriction at all, just by using this, you know, biometric fasting, the medic formulation.

Melanie Avalon
I have so many questions here. I just love talking about this.

Okay, so just a quick question about C. elegans. One, I'm just smiling and laughing to myself because I feel like I feel like C. elegans are used in lots of studies, especially on things like fasting, like I read about them a lot.

Were you actually like doing the research and like, like, like how big are it? Like, can you see C. elegans? How big are they?

Dr. Chris Rhodes
Yeah, you can definitely see C. elegans. That's a lot of the research that goes behind them. So we have, you know, we have a lot of cellular studies that happen with C. elegans. We have a lot of kind of like phenotypic studies that happen with C. elegans looking at how the genetics alters how they behave, how they look, how they grow, all those things like that.

But one of the assays that you can do with C. elegans is kind of like a, you know, a vitality assay for lack of a better term. So that's really just you looking at them under a microscope and seeing how vigorously they, you know, thrash around how fertile they are, you know, what their actual movement patterns and their activity levels look like over time. And that's really what we ended up seeing with the C. elegans lifespan. So like, not only could we extend their total lifespan, the amount of time they lived, but it also seemed like we could really extend their health span as well because these C. elegans were really like moving around. They were much more fertile, even in later stages of life where they would normally become more like docile and more dormant. So really not only just increasing their lifespan, but also it seems like their health span as well.

Melanie Avalon
Is there an understanding in the scientific community around life span extension with C. elegans for how this translates to humans?

Because I feel like we see, you know, we see 96%. Like you're not, you're not, you're never going to get 96% extension in a human. I mean, not right now. That'd be like almost double your, your life. Like what practically does that mean when applied to humans?

Dr. Chris Rhodes
Yeah, it's a really good question. And I think it varies depending from experiment to experiment, from organism to organism.

But typically how the progression of longevity research goes normally is you identify some candidate for a lifespan extension and you start testing it out in cells, right? And normally they're not even human cells. They're probably mouse cells or I'm like, maybe even see elegant cells, something like that. Once you find these cellular effects, then you move up to the organism level. And usually that next step is C. Elegans because they typically only live about a month anyway. So it's very easy to test lifespan extension interventions on them, but they still share a very good deal of genetic similarity to humans, which is really interesting. Then after that, you would probably go into a higher organism, maybe a zebrafish or like a drosophila, a fruit fly. Then you would go up to mice. Then you would go up to maybe dogs, and then you would go up to like chimpanzees, and then you would go up to humans. So the pathway of these lifespan extension interventions going from the initial cellular research up to the humans has a lot of gaps in between, I would say. And I think that the cool part about the bioemetic research that we're doing is that we kind of bypass all of that instead of starting in cells and then kind of leapfrogging our way up from organism to organism to organism and kind of hoping that it's going to have an impact on human health, we actually start with human research and then kind of confirm our results through the lifespan extension and animal models. So we know that whatever we discover from the human research, especially this bioemetic research is going to apply immediately to human health because that's where the research started. That's where the discoveries happened. And we're just seeing, does this thing that definitely has a context within human biology also work in these lower organisms?

Melanie Avalon
And so to that point, and I would love to go through the four different compounds, two questions that are related. One, because this is a supplement, not a medication, did that make it easier for the process of going through the studies?

And then, wait, side note question, did you ever think about going the pharmaceutical route versus a supplement?

Dr. Chris Rhodes
Yeah, yeah, no, definitely. I mean, me coming from the scientific and clinical background, I would have actually really liked to go down the pharma route. But the problem is that the way that the regulation happens with pharma is really, really antithetical to the biomimetic approach. So how things work in pharma is essentially, it almost always operates on a one-molecule, one-target style approach, meaning that we're going to create a chemical compound that targets a specific cellular pathway that's related to some kind of disease state ordinarily. So let's put it in the context of longevity and say like rapamycin. Rapamycin is specifically targeted towards inhibiting mTOR. And it doesn't do anything else. And that's kind of where it got its drug status from.

Just one molecule, one target, and lots of clinical research. For the biomimetic approach, we're talking about things, like we said before. In the fasting state, there are 300 metabolites that are upregulated during fasting. So if you really want to recreate these beneficial effects of fasting, and more holistically and accurately regenerate what's happening at the molecular level, you would need to use all 300 of those metabolites. And the pharma pathway cannot allow for that. Because the way that the regulatory works for pharma is that for every individual ingredient that you have within a formulation, you have to do individual testing for each ingredient, as well as testing for each various combination of those ingredients. So as you increase a formulation's complexity, then you also kind of create a higher and higher and higher mountain for yourself that you have to climb to get through the final pharma pathway to the point where it's basically impossible to do so. So in order to actually recreate the full biochemical complexity of the human body that happens during fasting, you cannot go down the pharma pathway. It's just not possible from a logistics, a financial, an economic, a timing perspective. So that's why the supplement pathway made a lot more sense. So really, we went down the supplement pathway because it was the way that we could make a better quality product at the end of the day with these multi-ingredient formulations that actually have these scientifically validated synergistic effects, because otherwise it just wouldn't have been possible to even make the product.

Melanie Avalon
Wow, yeah, that is so fascinating. Did you have, I know you said you were thinking about it, did you have a serious moment where you really did consider going the pharma route?

Dr. Chris Rhodes
Oh, yeah, absolutely. I mean, we were thinking like, like, okay, we only have four molecules, right? Like, what would this process actually look like? And what would the expense behind it be? And then what would the final kind of output be for it, right? It would have been, you know, hundreds of millions of dollars to be able to take this formulation through the pharma pathway. And then at the end of the day, it would have been kind of cordoned off from the general population, right? It would have been a drug with a specific use case for a specific condition or disease.

And that's what it would have been prescribed for. So you're taking something that was originally designed to help everybody and give them, you know, the power of their own biology on demand. And then you would have had to put it in the context of like, you can only use this for maybe, you know, 0.5% of the population who has this one specific condition. So it really would have, you know, taken a lot more time, a lot more expense, not been available to people who actually need it, who is, I think, in my opinion, like everyone, right? It's the universal human biology that we're mimicking here. And it just, you know, it would have really taken down the accessibility of the product. It would have prevented people from getting the benefits of them, which I think they deserve.

Melanie Avalon
This is such a fascinating conversation, and it reminds me of, I've had on the show David Sinclair a few times, and in his book Lifespan, he talks about how until aging itself is a disease, you're not going to really be able to have drugs to quote, treat it. So there's just like not a pathway there.

Dr. Chris Rhodes
Yeah, exactly. And I think that there's some really important strides that are being taken in the field right now to kind of address this a little bit.

I don't know if you've heard about the company loyal.

Melanie Avalon
Is it loyal?

Dr. Chris Rhodes
Yeah, loyal. So they are a they're a pharma company who is looking specifically at dog longevity.

And they are the first company to have ever gotten the FDA to acknowledge that aging is a disease and that can use drugs to treat it. And again, specifically, this is in dogs, right? So this hasn't been totally applied to humans yet. But loyal is the first company that's ever gotten, you know, FDA approval for a longevity treatment of any kind. So that's a very, very exciting kind of milestone in the longevity field of kind of opening the doors for human longevity extension drugs.

Melanie Avalon
super cool so maybe we can have a memo for dogs in the future pharmaceutical

Dr. Chris Rhodes
Yeah, oh, not to give too much away, but we are actually already working on a Mimeo for dogs products. So we just got the first prototypes for that made and are really excited to start doing the clinical testing after that.

Melanie Avalon
Oh, super cool. Congrats. That's really cool.

Dr. Chris Rhodes
Oh, yeah, we're very excited about it because I have you know, I have a seven year old husky pit bull mix who I love to death and I'm like must keep him around forever.

Melanie Avalon
And I think with dogs, doesn't their longevity correlate to their size? I think.

Dr. Chris Rhodes
Yes, it does. Yeah.

Well, smaller dogs definitely live longer than older dogs. And that's actually one of the things that Loyal as a company is trying to figure out. So they think that one of the reasons why larger dogs don't have as good longevity is because larger dogs tend to have higher circulating levels of IGF-1, which is of course a growth factor, right? So that gives them larger size, but it's also generally not great for longevity because it promotes cellular division, cellular replication. And the more your cells divide, the more they replicate, the more opportunity there is for DNA damage, mutations, kind of cancer formations, a lot of things that can go wrong, right? So that's kind of the thinking behind why larger dogs versus smaller dogs have these differential lifespans.

Melanie Avalon
Yeah, it's so interesting. But what's weird about it, because that completely makes sense.

And then you also wonder, though, why do we not see that across the entire animal kingdom? Why do whales live so long? And they're massive.

Dr. Chris Rhodes
Yeah, yeah, exactly. Yeah, I mean, the longevity does not take a straight path. Like if only it was that simple, maybe we would have solved it long ago. But yeah, exactly.

Like you have things like tardigrades, right? Like, you know, the little water bears that are also really highly used in longevity research because they're so hardy and can survive space and, you know, crazy amounts of radiation and things like that. And they can go dormant for 50 years and then like come back to life and you spritz bits of water on them. And then yeah, you have something super huge like elephants too, which are pretty long lived, but not as long lived as tardigrades or not as long lived as tortoises or, you know, some birds too. It's kind of, it's kind of just really interesting how the cellular mechanisms of longevity come about in the animal kingdom. And you have, you have like the jellyfish too, the immortal jellyfish that can just kind of button their way through life. It's really, really fascinating.

Melanie Avalon
It's funny, on the Mindblowing podcast, we actually talked about tardigrades the other day because we open it up with a mind-blowing fact. And we just talked about these things because A, if you Google them, they look terrifying. And then B, apparently they're just like the most resilient animal ever. Like they just don't die.

Dr. Chris Rhodes
Yeah, they truly do not they are they are fascinating to study and yeah, like, when you look at them really close up, they're super horrifying. And then if you take like, you know, just one step back, they're super cute.

Melanie Avalon
Yeah, they're super cute. So it's really interesting to see. It's so funny. Oh my goodness. Okay. So back to these four compounds. So you mentioned the OEA, then you also have PEA, correct?

Dr. Chris Rhodes
Yeah, that's palmitoyl ethanolamide.

Melanie Avalon
Okay, and then you have the nicotinamide-related one.

Dr. Chris Rhodes
Yeah, then they had nicotinamide itself. So that's serving as a broad spectrum NAD precursor in the formulation so when you take nicotinamide it gets converted by your cells into nicotinamide riboside and nicotinamide mononucleotide and NAD itself, so it's kind of giving you the Advantages of all three of those molecules, but just with one molecule and then nicotinamide itself is much more Well researched because we've been doing nicotinamide research probably since you know, the 1930s versus nicotinamide riboside or nicotinamide mononucleotide which we've really only started paying attention to More rigorously in the past, you know, 10 15 years or so

Melanie Avalon
Yeah, and for listeners with those other two that Chris is mentioning, people probably hear them referred to as NR and NMN, and it's the ever ongoing debate about which one to take and what is doing what.

Did you consider using one of those instead, or was it pretty clear that nicotinamide was the way to go?

Dr. Chris Rhodes
Yeah, we definitely considered using one of the other ones instead. But when we looked at the actual data from the fasting study, we didn't find that NR was upregulated.

We didn't find that NMN was upregulated. We found that nicotinamide itself was upregulated. So that was kind of our cue to say, all right, well, this is the molecule that we want to use and then the downstream benefits of also, you know, creating the NR and creating the NMN and creating the NAD were really important to us as well, because that's, you know, if you've existed in the longevity space for a long enough amount of time, you kind of come to realize that the whole NR, NMN, NAD debate is a lot of marketing hype and a lot of marketing press. And when you look at the actual scientific studies, the clinical studies that have been done with each of the molecules, they have, they all have very similar effects, which makes sense because they're all part of what we call the NAD salvage pathway. So that's that interconversion between nicotinamide, nicotinamide, riboside and nicotinamide, myonucleotide and NAD, they all just kind of like swap back and forth between each other from a biological and biochemical perspective. So as long as you're getting a form of these precursors that can actually be absorbed by cells, you will most likely be getting, you know, all the same effects, regardless of which variation of them you take.

Melanie Avalon
Yeah, I'm so, there's just so much information out there and I think it's very confusing to people. I've landed kind of in what you're saying that I think I would just, to be safe, take NMN and NR and I could take Mimeo and get all the things. The one that I feel, if I use NAD patches that I talk about a lot, I feel that the next day. Like that's what really, I notice a difference. So that's why I like that route.

But yeah, it's confusing. And I wonder, do you think when they were potentially banning NMN, that was because they wanted to make it into a pharmaceutical? Was that?

Dr. Chris Rhodes
Yeah, that was exactly the pathway. In the whole NR, NMN drama, there is definitely the impacts of what David Sinclair was doing and his NMN company, his NR company, where the patents fall, right? Because True Nyogen Chromadex is the one that actually owns the patent for NR, which is kind of why NMN ended up becoming so popular because people were like, well, we want an NAD precursor, but NR is already walked up with patents, so we need to create another version of it. So we'll do NMN instead.

And then NMN got all controversial because everybody started using it. And then, yeah, we wanted to make a pharmaceutical out of it. The FDA regulations around that are basically, if it's been sold for six months legally as a supplement, then it's grandfathered in. So even if a pharmaceutical is developed from NMN, then you would still also be able to sell NMN as a supplement. But then of course, the pharmaceutical companies that were making NMN didn't like that. So then they petitioned the FDA to kind of like, you know, make an exception for NMN so that they could sell exclusively and it couldn't be sold to the supplement. So it's, yeah, there's just like a ton of weird regulatory drama that goes along with all of this stuff, which is kind of another reason why we ended up choosing nicotinamide for the Mimeo formulation, because we didn't want to have to deal with any of that regulatory drama while still being very scientifically and clinically sound, because again, of basically the hundred years of research that has already been done on nicotinamide itself.

Melanie Avalon
Oh, yeah. What was the timeline of making it versus when that all happened? Because I know, for example, I was literally about to make an NMN and then all that drama happened and I was really sad.

So had you already had did you already have memo when that was happening?

Dr. Chris Rhodes
So this was happening at around the same time. We were seeing all the drama around NR and NMN, and we were kind of just like, I, like, you know, as a scientist, seeing all the clinical research, I can kind of recognize this as like, this is marketing drama, essentially, right? Like this is people fighting over technical definitions and patents and, you know, regulatory stuff. And we just don't really want to be a part of that when we don't have to be, right?

Like if I truly saw in the data that NR or NMN had these, you know, far better effects than just nicotinamide proper, or if they were really different pathways or really different metabolites, you know, we would have entered the fray. But what we saw from our own research, what we saw from the existing clinical evidence just showed us that nicotinamide was the more well-researched one. It was the safer one. And it was the, from our experiment, more effective version. So that's what we ended up using.

Melanie Avalon
Awesome. And then the fourth one, Spermidine, which I remember, I feel like there was a moment, I remember when people started talking about Spermidine and then I feel like there was this massive wave where it was like all the Spermidine all the time.

I might've mentioned this last time, but the moment where I became really intrigued with Spermidine was actually when I read an interview Dr. Michael Greger for one of his longevity books or maybe his like How Not to Die Book, I think. And he had a whole section on Spermidine and he mentioned this one study, which I probably should go and look exactly at how they did it, but they looked at a lot of different foods, I think like hundreds of foods. And they tried to find what was most correlated to health and longevity and Spermidine was like the thing, like the amount of Spermidine in the foods. And I was like, oh, that's really interesting. So Spermidine, what's going on with Spermidine?

Dr. Chris Rhodes
So sperminine is really interesting. Sperminine is what's known as a polyamine. So it's a breakdown product of amino acid metabolism. And in sperminine's case, it's specifically a breakdown product of arginine. And sperminine exists in a lot of foods across the food stream, but especially whole grains, because it's a very important growth factor for seeds and grains and things like that.

So one of the most abundant places to get it is wheat germ. That's where a lot of the current extracts come from. And sperminine itself is an autophagy promoter. That's kind of the thing that it's most known for. And the way that sperminine promotes autophagy is still up for a little bit of scientific debate. But basically what we know right now is that it is an inhibitor of an inhibitor of autophagy. So it's not entirely like directly promoting autophagy so much as it is inhibiting something that.

Melanie Avalon
would turn it off.

Dr. Chris Rhodes
Yeah, turn it off. Exactly.

That's kind of what we see in a lot of the literature research as well is that spermidine is really good at promoting autophagy, especially in the context of fasting. And what's really interesting about spermidine, kind of to your point before, is that it's been really well correlated with human longevity. So higher intakes of spermidine are correlated with longer health span, longer longevity. And there was actually a recent paper that came out kind of looking at health outcomes and dietary spermidine intake. And it seems like you get a really big inflection point for better health outcomes, better longevity outcomes at around 30 grams of spermidine intake per day. And Americans on a whole eat around eight grams of spermidine per day. So we seem to be pretty deficient in our general spermidine intake. So taking a spermidine supplement really seems like a great idea, especially with all of the large scale observational data that we have for spermidine intake being tied to longevity.

Melanie Avalon
Wow. Okay.

So, so to go back to its mechanism of action, I guess an analogy would be, if you wanted cars to go, you could make them go faster or you could just remove stop signs. So it's like removing stop signs. So out of these four, the OEA, the PEA, the nicotinamide, the spermidine, were they all... So spermidine, it sounds like a nicotinamide had a lot of research. Were OEA and PEA well known for these benefits or did you kind of piece that together?

Dr. Chris Rhodes
Yeah, we were definitely the ones that put PEA and OEA within the context of fasting. No one really knew that those molecules were upregulated during fasting before.

And in fact, OEA for a very long time was thought to only be upregulated when you eat food, right? Which makes sense, right? You're eating food, your body is going to produce OEA as a signal to say, hey, we have food, we're full, we don't need to be hungry anymore, we're all good. We found that yes, OEA was upregulated during these fed states, but it was even more highly upregulated during the fasting state. And we think that this is actually a evolutionary adaptation, right? Because let's say that you are in a 36 hour fast, it really doesn't do your body any good to have you doubled over in hunger pangs, right? Unable to move, unable to focus on anything else except for the hunger. So we think that OEA is the body's natural way of suppressing appetite in these longer term fasted states so that you can then focus on, I got to go find those berries, I got to go hunt that, hunt that gazelle, right? And actually be able to focus and concentrate on getting the food you need to get out of that fasting state.

Melanie Avalon
Awesome. Okay. And then the PEA, it's a natural endocannabinoid?

Dr. Chris Rhodes
Yeah, that's right. Yeah, it's an endocannabinoid involved in that whole system. It's able to cross the blood-brain barrier and specifically stimulates through PPAR alpha, simulates through CB1, CB2 receptors, as well as being a COX1 and 2 inhibitor. So what all of that means together is that essentially it's acting almost like your body's natural CBD.

So it has these mood elevation effects, it has these cognition enhancement effects, it has these anti-inflammatory effects, and then it also has this really interesting effect on pain relief. So you really get a relief of nerve pain, joint pain. There's been a lot of interesting studies on PEA in terms of like fibromyalgia or diabetic neuropathy or even menstrual pain where PEA has shown really, really great effects and even greater effects than ibuprofen when they compare the two together.

Melanie Avalon
Wow, that's cool. And these effects, is it something where you have to be taking it for a while to get the benefits or does it work pretty immediately? What does it look like for people?

Dr. Chris Rhodes
Yeah, that's a great question. I would say that there are some effects that you might be able to feel right away, like the hunger suppression effects from the OEA or the discomfort pain relief effects of the PEA. What we have seen in our clinical studies, which have typically taken course over an eight week timeframe, and a lot of the other clinical studies that have been done with the individual ingredients, it seems like it takes around eight to 12 weeks for significant impacts to really be able to be measured from the biomarker analyses, from the quality of life analyses, from like the surveys and the questionnaires and things like that. But we have had plenty of people who are on the MIMIO formulation who can feel the effects right away and have had especially the appetite suppression effects.

So one of the things that I was really excited to talk about today was we just finished our large scale, randomized, double blind placebo controlled study with the MIMIO formulation. And in that study, we were basically looking at what happens when we take older folks, 55 years and older, and in equal proportion of men and women, we put them on MIMIO or placebo control for eight weeks, but we don't have them alter their diet or lifestyle anyway. And what we found there was that there was this very profound effect on appetite suppression, hunger control. So these people were rating their distractions from cravings as significantly lower after eight weeks, their maximum and overall daily hunger as lower after eight weeks, they had much better ability to eat only when hungry, and they had a much better satiety. So basically getting fuller faster and staying fuller longer from the meals that they were actually eating. So that was a really big effect there. We saw lower bloating, lower digestional discomfort when people were eating meals. And then when we looked at the blood markers themselves, we saw these really powerful impacts on metabolic markers. So better glucose levels, better cholesterol levels, lower LDL levels or bad cholesterol levels. We have lower cellular stress levels. We have lower inflammation levels. So all of the things that fasting would be doing for you, but just through two capsules a day of MIMIO and without changing diet or lifestyle at all.

Melanie Avalon
Oh, wow. First of all, congrats. Amazing. That's incredible.

Wow. So going into and setting up that study, did you have to choose to power it to detect? Because you just mentioned so many benefits. Were you focusing on, you know, measuring only a few of those or like how many things can you realistically test in a study?

Dr. Chris Rhodes
Yeah, we had the advantage of working with a really great decentralized clinical study operation called People Science. They really helped to reduce the cost of the clinical study overall, because usually you would do these things through a university or through a third-party research organization that has a singular physical location and that has a lot of overhead that's related to it.

Using these decentralized clinical study platforms, we can reach a lot bigger audience because we're recruiting from everywhere around the country, so we not only get a larger audience but a more representative population of the American public. And then we can have them all just go into lab cores which are all around the country to get their their blood work done. We can use app integrations to get their questionnaires and do cognition games and like all kinds of cool technological tracking of their bio data. So it was really really cool to be able to work with People Science and do this clinical study where we got to touch a lot of different data points for much lower overhead costs than we would have otherwise had to spend to do a clinical study of this magnitude.

Melanie Avalon
That is so cool. Okay, I just have a question.

Was there a moment, like do they give you an indication or do you see the results of that's coming in or is it like completely you don't know and then there's like a moment where you...

Dr. Chris Rhodes
We were blinded throughout the whole thing, which basically means that, you know, we don't get to see the data until the entire study is finished. And even after the entire study is finished, when we do the analysis of the data, we don't know which group is which. So it's all completely unbiased when we do the analysis and we get the data.

Melanie Avalon
So was there a moment where it was like the result moment?

Dr. Chris Rhodes
Yeah, there was definitely a result moment. Leading up to the trial finishing, it's a hugely stressful moment, right?

Because up until that point, we had already done two clinical studies showing that the MIMIO formulation worked, right? But they were a bit smaller scale, because that's how science operates, right? You start small and you get bigger, you go bigger, you go bigger, you go bigger. So this was our first gold standard, randomized, double-blind, placebo-controlled study in a very large population set. And throughout the process, I was like, man, fingers crossed, fingers crossed, fingers crossed, fingers crossed. So when the data actually came in, and we saw these great impacts, I was just like, yes, we have something that is super impactful. It's making a difference in people's lives, and we can see the data. I think that was the biggest thing for me, especially as a clinical scientist, is like, there it is in black and white, kind of unimpeachable in a gold standard study. This works.

Melanie Avalon
amazing. Wow.

Yeah, I'm not justifying this. But just hearing that story, you can, I can see how people, you know, or entities will fund these studies and then not get the results they want. And then they kind of, you know, make the abstract and title pull out like one piece of data, you know, to that supports them. And it's not I'm not justifying it. But it's like, it must be exhausting for people who actually go through all that and then don't get the results they want.

Dr. Chris Rhodes
Yeah, no, absolutely. I think that you do end up seeing that all the time. And a lot of times when companies do this work, if they don't get the results they want, they won't even end up publishing. And then like you said, the ones that, okay, well, we got one or two hits off of the 20, 24 things that we actually tested, we're going to put that in a paper and just be able to use it.

This was actually a big controversy that happened with another dog longevity company, Leap Years. They kind of had a big blowback because they were making very big claims about a clinical study that they had done with dogs where they had tested kind of like 20 things. They got one hit and they were like, oh, okay, cool. In this one, we improve things. And they started making these big claims about it improves dog cognition and prevents brain aging, that kind of stuff. I think that we have to be very careful about that as an industry of not putting the cart ahead of the horse and really focusing in on let's make sure that we are actually giving people something that works and something that's going to make an impact in their lives. So the way that I think about it is very much like I always call myself a selfish founder, because I'm making products that I want in my life and I want them to work for me. So it doesn't do me any good to sell anybody snake oil because at the end of the day, I want the benefits of the product and I want all the things that I say are happening with it. So I'm motivated to make a product that actually does work because I want it to work for me.

Melanie Avalon
I cannot agree more. That's exactly how I am.

I think going back to the conversation about pharma versus supplement companies, I feel like that's much more common with supplement companies where it's founder-focused. You know who's making it and why, and they often want it for themselves. So awesome, incredible. So is that your latest? Are you working on another study? Because you mentioned you had a few different things.

Dr. Chris Rhodes
Yeah, so the two things that we're working on right now are the pet side of the coin. So getting that made and getting that tested out, I'm really excited for that because of the great lifespan extension data that we already have from the C. elegans and the great clinical data that we have in humans. I'm very confident that this is going to be a great pet product as well.

But then on the back end, we are also, of course, as just part of our biometric research platform, looking at these other interesting states of the body. So just like we ran this process with fasting, we're really excited to run it with things like exercise and meditation and sleep and cold exposure. And it really tees out what is happening in the body during these states. And is there a way that we can recreate those benefits on demand? And the next one that we're really looking at is exercise. And we already have a couple data sets that we're working from where we can see, oh, there are these specific molecules that are uniquely upregulated during different types of exercise. And we're thinking that we can use them to kind of recreate those exercise-like benefits.

Melanie Avalon
Oh, awesome. And would this be something that athletes could take or are there issues with what you can and can't take being a professional athlete?

Dr. Chris Rhodes
Oh, yeah, no, definitely. So everything that Mimeo works with is all going to be things that are naturally produced by the body, right? So by the by the FDA regulatory framework, anything that's a metabolite can automatically slot into the dietary ingredients category. It's so it's a natural molecule like that. So it shouldn't it should be totally water compliant because it's all just going to be part of natural human biology anyway.

Melanie Avalon
Awesome, awesome. Oh my goodness, this is all just so incredible.

So vet listeners are super eager to get some Mimeo now. What forms can they buy it in? What's like the dosing protocol? We do have a code for listeners, so we'll give that.

Dr. Chris Rhodes
Yeah, so the form factor right now is just two capsules per day. That's what we have done in all of our clinical studies and that's how we're selling it right now.

We definitely want to explore some more things down the road like gummies or maybe incorporating it into mouth dissolvable strips that are coming onto the market. So that's something that we have on our radar for sure. But otherwise, yeah, just two capsules per day and you can take that with food. That's how all of our clinical studies have been performed. Or you can take it like I take it as a fasting enhancer to just kind of jumpstart, supercharge the benefits of your fast and make fasting easier.

Melanie Avalon
Awesome. So listeners go to memiohealth.com. That's M-I-M-I-O health.com and use the code I have podcasts to get 20% off.

So again, memiohealth.com M-I-M-I-O health.com and use the code I have podcasts for 20% off. Perfect. Oh my goodness. Well, this has been so incredible. We're just going to have to have you on annually if you're down because there's just so much. I just love geeking out on all of this with you. And you're always doing so much. And it sounds like there's many developments on the horizon. So thank you for what you're doing. We'd love to have you back again.

Dr. Chris Rhodes
Absolutely. This is always a good time. I love nerding out about longevity and biohacking and all this fun stuff with you, Melanie. It's always a good time. So happy to come back whenever you like.

Melanie Avalon
Awesome, awesome. And hopefully, hopefully I'll see you at Unimonia Conference.

Dr. Chris Rhodes
Yeah, absolutely.

Melanie Avalon
Awesome. Well, thank you, Chris. We will talk really soon. You are the best. Again, listeners, MemeoHealth.com. Use the code IF Podcast for 20% off. And awesome. I will talk to you next time.

Dr. Chris Rhodes
Alright, awesome, thanks for having me.

Melanie Avalon
Bye. Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes.

We couldn't do this without our amazing team. Editing by podcast doctors, show notes and artwork by Brianna Joyner and original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week. you





 

 

Oct 20

#444 – Fasting, Food & The Bible, Processed Foods Vs. Whole Foods, Dieting Problems, Offending People With Food Choices, Cultural Food Choices, Fasting And Gas Issues, Digesting, And More!

Intermittent Fasting

Welcome to Episode 444 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, biohacker, founder of AvalonX, and author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine, and Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC

SHOW NOTES


SPONSORS & DISCOUNTS


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LINKS

Featured RestaurantLe Bernardin

STUDIES:

Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts!

Original theme composed by Leland Cox, and recomposed by Steve Saunders.


Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.


TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)


Melanie Avalon
Welcome to episode 444 of the Intermittent Fasting podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat, with no calorie counting, then this show is for you.

I'm Melanie Avalon, biohacker, founder of AvalonX, and author of What, When, Wine. Lose weight and feel great with paleo-style meals, intermittent fasting, and wine. And I'm joined by my co-hosts, Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC. For more on us, check out MelanieAvalon.com and BarryConradOfficial.com. You can submit questions for the show by emailing questions at iapodcast.com or by going to iapodcast.com. We would love to hear from you. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time, and get ready for the Intermittent Fasting podcast.

Hi, everybody, and welcome. This is episode number 444 of the Intermittent Fasting podcast. I'm Melanie Avalon. I'm here with Barry Conrad. Barry, how are you today for episode 444?

Barry Conrad
That's so crazy. Is that like good luck or something? What is that? 4-4-4?

Melanie Avalon
I mean, I think if we say it is, then it is.

Barry Conrad
We've decided it is. It's good luck. That's a good thing.

I'm great. I'm doing good other than I actually have an injury. Oh, I, this week, the beginning of this week, there's a scene that we do where there's like, it's a towel fight. It sounds really mundane, but I'm running around doing this towel fight. And I basically, as I was flicking my right arm at the exact same time, I knocked my foot against one of the tables. So the way I flicked my arm sort of rotated in a tricky way and it aggravated an old injury that I had like five years ago from doing a high dance musical theater show. And so I've been in the physio the past little while.

Melanie Avalon
Oh my goodness, I'm so sorry. Is it getting better and is it limiting or impeding when you, you know, rehearse?

Barry Conrad
Thankfully, like, thankfully I can just use the other arm for the action and when I also have to pick up one of my co-stars, but it's not too high. So it's been thankfully okay.

Like I'm so glad you don't want to go into the season and be injured. But yeah, just like, it's so crazy how there's an injury from so long ago, like rotator cuff. My right rotator cuff is just like, it's just like annoying. Like if it gets niggled, because now I haven't been able to go to the gym this past week, but I can go, I've been given the okay to go back on Monday. So that's good. I just have to take it easy and ease into it.

Melanie Avalon
Do you have a red light device?

Barry Conrad
I actually don't anymore because I left it in Sydney, so I don't have 9-0. It's annoying.

Melanie Avalon
Yeah. Cause that's really helpful for things like that. Um, I am so sorry. Oh, that's you. It's not your fault, but yeah, that you could do.

It's, it's interesting. Listeners should check out episode 438. I interviewed on that show, Dr. Christopher Meadows, Barry, you would, you would really like the conversation. He, I met him through Cameron chestnut, who is kind of has a large social media following for cosmetic surgery and procedures that he does, but he has a very like biohacking, like approach to recovery. And he doesn't even use traditional anesthesia and things like that. Somebody at his clinic is Dr. Christopher Meadows, and he played football at UCLA. And then he went to medical school and his focus is regenerative medicine. And so this he, what, what he does really is work with people with injuries and helping them recover. And we talked about, you were mentioning how this kind of like reactivated an old inner injury. So he was talking about using diagnostics to treat like new injuries versus chronic injuries that you've had. And we talked a lot about the role of fasting and recovery. So that was a really, really good episode to listen to for people who might be experiencing things like Barry with, with injuries, either ones that won't go away or new ones and also the role of fasting and all of it.

Barry Conrad
Yeah, that sounds really interesting. I need to get that, need to listen to that for sure.

Melanie Avalon
So yeah, it's a lot of like peptides, stem cells, like PRP treatments and things like that.

Barry Conrad
I've done, I did needle it, they did needling on me as well, which really did help a lot. Have you done that before?

Melanie Avalon
I have, yeah. And I actually had it done at a physio type place. I've had it done in my jaw actually. Your jaw? Yeah, for like TMJ, TMD. Okay. Did it help you?

Barry Conrad
I think it really did. It's a bit achy, but there's more of a release, and I definitely feel like by the time Monday rolls around, because she also took me through my range of motion and movement now, and the shoulder, and it's bounced back pretty well, so I've got to also give intermittent fasting some credit for that, because it was pretty quick.

Melanie Avalon
Yeah, I think the fasting is so good for just maintaining an anti-inflammatory state in the body. And then with the needling, my understanding that the way it works is that it helps... One of the ways that it works is it stimulates a minor injury in that area that helps boost stem cells going to the area and helping repair.

I think that's one of the mechanisms of action there. So your own endogenous stem cells, basically.

Barry Conrad
It's actually so amazing because it was talking to the physiotherapist and I said, who invented this technique? Like it's, it's so crazy how someone just made this up or discovered that this works. You know, it's amazing needling.

Melanie Avalon
Yeah, because it's been around forever, right? Like traditional Chinese medicine and things like that.

Barry Conrad
Thank you, Panksha. Yeah, exactly.

Melanie Avalon
Well, keep us updated.

Barry Conrad
I will.

Melanie Avalon
Hope you're back to complete sparkles very soon

Barry Conrad
I won't go mountain climbing or anything today, it's all good.

Melanie Avalon
Yeah, maybe maybe don't do that. I mean, I would never go mountain climbing, but

Barry Conrad
How you doing?

Melanie Avalon
I am I'm good I'm in a big transition phase right now with my business we're actually hiring three people so I've been doing lots of lots of interviews. Which this this is something it's so interesting to be on the like the hiring side of the table because you realize you realize.

Because I just get flashbacks to when I used to interview for things and I'd be like I would think I was like the perfect candidate and you realize there's so many things that go into it that are not necessarily even you and I especially with like auditions and things you know like you just don't know like all the factors for why they've cast certain people. So it's been an interesting experience to like I think I've interviewed like I don't know 15 people or so and just the seeing like who I ended up picking and why and then also feeling like it's such a big decision that's going to have such a big effect on my future of my company so it's it's been it's been a lot been like baptism by fire but I've been enjoying it I'm really excited about the new team I'm creating.

Barry Conrad
That's amazing. Give me an example of what you mean without going into detail of in terms of it's interesting what you how you selected them and it made you realize it's so not just about X, Y or Z.

There's so many factors.

Melanie Avalon
Yeah, so like an example would be being I now understand how you can be overqualified for a position. So like we had one girl who was really amazing. And she's getting her master's right now, she's going to graduate, you know, in a year or so I don't know when she's when she was going to graduate. But I remember thinking because the job she was applying for is very applicable to her right now. But once she graduates, you know, she probably would either really up her rates or might look for a full time job elsewhere. So it's like she's almost too qualified for the position, if that makes sense. And that she I don't think she would like stick with the position in the future. So things like that.

I had a lot of well, if you're ever applying for a position with me, if you want to know so when I'm like going through all the all the proposals, because I've been using Upwork a lot to do this. And so you get tons of proposals, like tons. So you have to go through and you have to just like quickly, you know, eliminate a lot of them. So people who use long dashes. If I could tell if I could tell they use chat. Nope. So, you know, I mean, use chat, please use chat, but clean it up so it doesn't look like chat. You know, so yeah, but it's, it's been a really great I'm actually I'm very excited about the three girls that we are hiring.

Barry Conrad
That's very exciting, very, very exciting.

Melanie Avalon
Yep, shall we jump into some fasting related things?

Barry Conrad
Let's do it. You have an amazing study for us today, Melanie Avalon.

Melanie Avalon
I do. I'm very excited about this Barry Conrad. Barry Conrad, who I appreciate so much in my life, telling you that right now.

Okay, let me get the study. So this study is called, well, it was published in Cell Metabolism. It was 2019. But the reason that I picked it is this was actually the first ever randomized controlled trial that looked at the effects of ultra-process foods and if they cause weight gain or not. And it's by one of my favorite researchers, Kevin Hall. I'm like a fangirl of a researcher. I should try to have them on the show. Let me write that down. So the study is called, ultra-process diets cause excess calorie intake and weight gain and inpatient randomized controlled trial of ad libitum food intake. So the setup of this study, the purpose of the study was, as they say in the intro, that scientists at that time had not yet been able to actually demonstrate that ultra-process foods cause obesity or problematic health effects. So they wanted to do an actual randomized controlled trial to look at this. And I find this so interesting. So the setup was they had 10 men, 10 women who were at a stable weight and this was an inpatient situation. So they weren't doing this at home. They were like, it was very controlled. And they did it for 28 days and they were randomly assigned to either an ultra-process diet or an unprocessed diet. And they did both of them for two weeks. So basically like 10 of them did two weeks of ultra-processed while the other 10 did processed and then they flip-flopped. And the way it was done was they just presented three meals a day, but they give them snacks as well. And they gave them two times the amount of calories that they needed to maintain their weight. So basically it was like a free-for-all, all this food, eat whatever you want, we're going to see what happens. And the people who ate whole foods, it was whole foods. The people ate ultra-processed foods. And the definition of ultra-processed foods according to the Nova classification is, so those are industrial formulations made with multiple ingredients, including those found in processed foods like sugars, oils, fats, salt preservatives, plus additives for taste and convenience. So it's things like soda, chips, American cheese, frozen pizza, packaged cakes. meat products, chicken nuggets. And by meat products, it's like processed bologna or pepperoni or something. So what they found was... Oh, and what's really important is they tried to match, as close as they could, they tried to match the meals for total calories. So it was the same amount of calories for the processed and the unprocessed, same energy density, same macronutrients. So they tried to make it the same amount of carbs, fats and proteins, same fiber, same sugar, same sodium. The only thing that was different was... Well, the main thing that was different was how much of it was processed versus unprocessed.

Melanie Avalon
And then also there were some things that they couldn't quite match up because it just... They couldn't do the math. Like it didn't work to make it match. And that was things like added sugar. So there's clearly way more added sugar in the processed foods, insoluble to total fiber ratio, saturated fat. There was way more saturated fat in the processed foods. And then omega-6 to omega-3 fatty acids, there was more omega-6 in the processed foods. And so what they found... And again, these people were not told to try to lose weight or gain weight or anything. They were told just to eat, was that the people when they ate the un... So when they ate the processed foods... Let me get the number. They actually consumed around 500 calories more when they ate the processed foods. And they also gained more weight.

The patients on the ultra-processed diet gained around a pound during the ultra-processed diet. And they actually lost around a pound on the unprocessed diet, which is so fascinating because these people weren't told to try to lose weight. And by eating just unprocessed foods as much as they wanted, they actually lost weight. Whereas by eating processed foods as much as they wanted, they gained weight. And what's also interesting is that the experience of the people was the same. So when they were eating processed foods versus unprocessed foods, at the end of their eating time, they felt equally satisfied. So people were eating 500 calories less and feeling the same as the people who ate 500 calories more than that just because they chose whole foods versus processed foods. And they actually saw in the unprocessed food group that their levels of ghrelin, which is a hunger hormone, actually went down. On the flip side, they found that the hormone PYY, which actually suppresses appetite, went up. So they were experiencing beneficial changes from eating the whole foods diet that made them less hungry, essentially.

One of their theories, because this is also interesting, was they seemed to eat the same amount of protein both groups did. It's just that the people who ate the processed food ate way more fat and way more carbs. So they were saying that this might be the protein leverage hypothesis showing up, which is basically that we keep eating until we hit the amount of protein that we need. So it's possible that the people eating the processed foods kept eating the processed foods until they hit that protein number, and then they stopped. And so in that process, it made them eat more fat and more carbs. Yeah, so that was the main takeaways from it. Basically, their conclusion was that processed foods have a big effect in actually leading to weight gain, making us eat more linked to negative health conditions. So going the whole foods route is the way to go. So what are your thoughts on this, Barry?

Barry Conrad
As soon as you mentioned the title for this, I was like super interested to see what was going to happen. And I'm not surprised that it probably took the ultra-process group longer to probably get the satiety as well and just keep eating until they got those macronutrients that the process slash whole foods goop had.

I'm not also surprised that it's interesting that it's like a pound either way for both groups. I actually maybe thought that would have been a bit more even for the ultra-process. Do you know what I mean?

Melanie Avalon
It's like shockingly similar. It says with participants gaining 0.9 plus or minus 0.3 pounds during the ultra-process diet and losing 0.9 plus or minus 0.3 pounds during the unprocessed diet. Almost the exact same amount, which is really crazy.

I agree with you. I thought about that. Like maybe with the ultra-process diet, you just like from a literal time perspective, it takes a second to get that satiety signal. And so you probably eat more before you feel full, before your body to give you a feedback loop.

Barry Conrad
So the processed food, to clarify the process, is the ultra-processed? Because did you say ultra-processed versus processed?

Melanie Avalon
culture process.

Barry Conrad
Okay, so the ultra-processed food, naturally, that makes total sense that the 8500 calories more. You could just keep eating as well, because when I'm having a bag of chips, for example, I'm going to keep eating that bag until it's done, whereas if I'm having a steak, I'm going to feel so much more satisfied and satiated, because my body's going to tell me, so it's just... Yeah, but still, even with that, I'm still quite surprised that it's not that much more than a pound gained.

I was expecting a bit more weight, which is crazy, because it's basically heaven for people who love junk food, quote-unquote, just to eat as much as they want, you know?

Melanie Avalon
So to that point, because I think that's like such a good point, we do know, I think this might have been a little bit protective. We know that there's something called the Hawthorne effect, which is basically when you know you're being monitored, you change your habits accordingly.

So just the fact that they're in being like in a study, being monitored, they probably, with the ultra processed diet, they probably didn't eat as much as they would have if this been like at home, you know, because I do think I'm actually I am surprised they only gained that, you know, only 0.9. But do you get what I'm saying?

Barry Conrad
What's that called no the what effect hawthorn effect that's really interesting and makes total sense because if you are being watched so. It's like any situation like if i'm being seen or watched i'm not gonna be behave exactly the same way i might behave. Depending what it is you know if i was at home alone with anyone watching.

Melanie Avalon
Yeah, it's so it's like defined as individuals modify their behavior simply because they are aware of being observed during a study or experiment. It actually makes it really, really hard to do unbiased research because you can't control for this effect because people are going to modify even if they don't know they're doing it.

Barry Conrad
I didn't even account for that because I was initially looking through all these other points you made like 10 women, 10 men, very in a clinic, inpatient, you know, very controlled. And so I'm like, well, then how is it only a pound?

But now that you mentioned that, that makes total sense.

Melanie Avalon
Yeah, so and on top of that, so two things. A, that observation probably made them, you know, not eat as much as they would have. And then B, we know that when people are going on like a any sort of prescribed diet, even though it was ad libidum and they can eat whatever they want, regardless, when you go on like a prescribed diet type thing, you tend to actually eat less. So just by that change, so that probably it's a similar factor.

But and I just I just pulled up, I hadn't looked at this, I just pulled up the supplementary PDF that goes with it. Do you want to hear like what what the diet kind of was? They have pictures of the meals and everything.

Barry Conrad
Yeah, sure. I want to see it. Yeah, awesome. Tell me.

Melanie Avalon
So it's things like, for breakfast, like Honey Nut Cheerios, whole milk with Nutrisource fiber, blueberry muffin, lunch was like beef ravioli, Chef Boyardee, Parmesan cheese, white bread, margarine, diet lemonade, oatmeal raisin cookie. And then dinner was like Tyson's steak with gravy, mashed potatoes, margarine, corn, diet lemonade, low-fat chocolate milk.

They go through the entire two weeks. So let me see if there's anything else. Like, let's see, hot dogs, potato chips, cranberry juice, bagels, a lot of diet drinks, apple juice, cheeseburgers. So it's things that people are eating all the time, you know, like normally sandwiches with deli, turkey and American cheese. So it's wild that these foods that are so seemingly normal to people, that people just eat 24 seven, that it could be having that big of an effect on, you know, I mean, everything with our weight loss and our health.

Barry Conrad
Of course, and just like even being in a workplace, meaning like I'm not normally in a workplace unless I'm doing a show, you know, I usually do my own thing, but when being doing a show and seeing people's habits and whatnot, which is all power to whatever you want to do. But it's just there's so many snacks, there's so many, there's so much access to snacks and things like that.

And it's interesting to see what people see as like, Oh, this is just a normal little thing. I feel hungry. So I should eat this in my head, I just wouldn't, you know, it's just so interesting. Yeah.

Melanie Avalon
I think about this a lot kind of similarly, like I think about this like with the snacks like you mentioned, the if somebody gets like a they could get like a cookie, like a thing of cookie snacks, or I think of chips, and it could be like, you know, 300 calories. And you can just eat that so fast, and it's like just a little snack and like what like what hard like what harm is it going to do?

Think about how much whole foods you could get for that same amount of calories.

Barry Conrad
I 100% know what you mean. It's scary actually.

Melanie Avalon
Really is. I actually, I don't know how we're not bigger than we are.

Barry Conrad
But also, like, again, and I just want to make clear as well, I'm not demonizing you. Everyone eat whatever they want to eat.

I'm just saying it's interesting how what is what people believe based on just conditioning or what they have grown up with, they think is just okay, it's just something little and it's no big deal. But in, I think for people like Melanie and I who have more, we're just more informed with what the content of food is. And just to see, wow, that's that's a 500 calories, quote unquote, snack really small. But I can eat so much like animal protein and, you know, and so much more satisfying.

Melanie Avalon
Yeah, I think it's like we just we just don't see it. You know, if people could just see it.

One other thing that was really interesting. I'd be curious why you might what you think might be going on here. There wasn't a big. So when they ate the whole foods, there wasn't a big difference. Like they basically consume the same amount throughout the two weeks. But with the unprocessed, there was a linear decrease. So basically, they ate more in the beginning with the ultra processed foods. And then as the day went on, they actually started it they titrate it down a little bit.

Barry Conrad
Well, my thought on that is it's the whole thing where if you can't have it, it's more fun to have it, but if you can have it, it's like, Oh, well, your body's probably more checked into like, I don't, maybe I don't actually don't want as much of it. You know, it's like, it's that initial feeling like, yeah, I can do whatever I want. That's my thought psychologically.

And even physiology, physiologically, feeling not as great eating too much of it, you know, getting bored.

Melanie Avalon
Yeah, and I think I think also maybe maybe the body does adapt like maybe like when you first get exposed to if you if you're coming from like a unprocessed diet or just not an all processed diet, the body might like at the beginning you probably just need to like eat all the things to even feel full and then maybe the body starts adapting to it you know your microbiome changes and then you can maybe get along without having to quite stuff yourself quite as much but yeah I don't know.

Barry Conrad
I do think one of the amazing things about intermittent fasting, Melanie, and tell me if you agree or not, is that over time, it doesn't mean that you might not still want trinkets or junk food and things like that, because for me personally, I still enjoy it. But it's interesting that knowing that I can have it if I want to, but just that knowledge means like, oh, it's actually not an emergency that I'm not having it.

It's like because I can have it, it's not a demonized food. So does that make sense?

Melanie Avalon
It completely does. So I'm a little bit different in that I guess I could have anything. I just know if I were to have it, I would not be happy or having it, nor for me, because of the feeling that it creates in me. And what I'm thinking of in comparison is what I like about fasting is not having food during the day and looking forward every night to like this wonderful meal is just so fabulous compared to when I was back in the day like dieting and like I think the most miserable experience of dieting is you're never full because you're just constantly you know restricting and then you have to finish eating before you're full and then you have to wait again to eat at which point you're not going to eat until you're full again and then you have and then it ends. It was so sad. It was like such a sad existence. Not I mean I wasn't like emotionally sad but I'm saying like it was not fun. Like I still it's been so long since I've done that and I still shudder remembering it like how horrible it felt.

Barry Conrad
I still believe, well, because I see it, that that's still something that's preached, but especially online anyway, certainly online that don't eat until you're full or, you know, it's okay to go to bed hungry. It's fine if you want to be skinny, just it's dangerous. I don't like that.

Melanie Avalon
I hated going to bed hungry. Oh my goodness. I just hated like being hungry all the time.

Whereas now I do get hungry during the fast actually but if I ever do it's not an emergency feeling and it's more like oh I'm excited to eat later feeling if I get hungry.

Barry Conrad
It's also, just to add to that email, I just think, in general, food is just such an emotional topic for people. It really is, and so personal. People get so, not triggers the wrong word, but just passionate about, well, why can't I have that? Or, I don't know, it's just very, it's very interesting. Very, very, very interesting.

Melanie Avalon
Actually, that's crazy timing, so this is going to be way in the past for listeners. But the episode I'm releasing this week on the Melanie Avalon biohacking podcast is with Ben Greenfield, who is like a legend in the biohacking sphere.

We actually talked on the show because he's Christian, and we talked a little bit about like his bio, like was Jesus a biohacker? And one of the things we talked about that I really liked was there's this verse in the Bible. There's this story in the Bible where it's a, I don't know if you remember it. It's about eating certain things at the table and like whether or not to eat them. Do you know which Bible verse I'm talking about?

Barry Conrad
Can you say the verse so I can, maybe it'll.

Melanie Avalon
Okay, so it's 1 Corinthians 10, 27 through 29. And it says, if one of the unbelievers invites you to dinner and you are disposed to go, eat whatever is set before you without raising any question on the ground of conscience.

But if someone says to you, this has been offered in sacrifice, then do not eat it for the sake of the one who informed you. And for the sake of conscience, I do not mean your conscience but his.

Barry Conrad
Hmm, I do remember that.

Melanie Avalon
Yeah, and because I remember I used to, I actually used to get into arguments with my mom about this verse, because when I first started doing low carb, I think it was in college and I would go home and I would like not, I would at the restaurant, I would, you know, not I would not eat the cake. And I think it kind of made her like sad, because she wanted me to, you know, things that were like emotional, and like memories, I but I wouldn't eat them anymore.

And it's funny, because we would argue over this verse, because she was saying like, versus eat the things I'm like, Mom, the verse says that you don't have to eat the things or like that. I was saying that the verse was saying that you shouldn't inflict your own diet on other people. Like you could use this verse to say either either way, because maybe I'm going to the dinner and not eating the things and that's the problem. But also maybe it's saying that, you know, that you shouldn't question what other people are eating. It's just funny, because Ben Greenfield and I were talking about it. And we're talking about like dietary dogma and having your own choices. But also, you know, when should you change your choices based on the company that you're around? I don't know how I got on this tangent. But I think it's really interesting.

Barry Conrad
It's, Mel, this is fascinating because now that you brought this up, I do remember as a kid, we were always taught, or whatever's served at the visitor, we call it visitors, at the visitor's house, just you eat it. Just be polite and just you eat it.

Just don't question it. Just eat it, unless you're allergic, just eat the food. And I took that into a lot of my adult life, whatever they cook. And in most cases, because we are different in that way, I will eat more of a range of things because it doesn't cause as many health situations in terms of it. But I don't love it sometimes, but I'll still eat it because it's like, I guess I can eat this. But I'm always happy doing it. Now I don't do as much at all.

Melanie Avalon
What's so interesting though is like it's so, because like I said, we used to use this verse and we would use it to say different things because on the one hand, because it's basically the first part of it is saying, like in your example, when you go to somebody's dinner, eat what you're served, like for, you know, for them, because you don't, and like what this verse is saying is you don't want to make it like a whole, a whole thing for them. I was using it to say the opposite, which is like, I feel like the spirit of the verse is that in general, we shouldn't impose our own dietary beliefs on other people.

So if I want to eat low carb, I should be able to eat low carb, you know? Yeah. Now I just, I just eat whatever I want to eat. So I'm trying to think if I've been in a situation where it's very cultural, like I would struggle, it would be hard if I had to go somewhere where it really is going to be really offensive, you know?

Barry Conrad
Totally. I think in that case for me, I would try and I probably wouldn't succeed entirely, but I try to see, okay, what is the protocol? What is the situation I'm going into? Are they going to expect this, this, or this? And if I'm comfortable doing that, I should totally go.

But if I'm not comfortable, then is it worth? I don't know. Also, some people might say it's just food. Deal with it.

Melanie Avalon
it's so emotional, it's so cultural. And of course, you don't want to offend people, especially if you're going, if it's like a situation where it's cultural, and it's gonna be very offensive to not eat it. But, and then also, though, in my head, I'm like, well, I should not have to eat something I don't, don't want to eat, like, I don't think it should actually be offensive to people. So, but that's coming from a completely different foundational view of it.

And people have different perspectives. So, like you said, I, I think if I knew it was something where it was going to be super offensive, and it was something where I knew I was not going to feel well in the situation of eating it, I probably would just not go. This is only this is I mean, I'm good anything in America, I'll go to, but if it was something like, I don't know enough about different cultures. So there I know there are probably situations where it would be like a horrible offense culturally. I wouldn't want to do that to them.

Barry Conrad
Because I do know definitely food is very personal to some, like, for example, going to like a Samoan family's Sunday lunch, like, they get offended if you don't not only eat whatever's everything on the table, but have more and more, like, no, keep, no, have some more, like, that's like a sign of, it's so interesting how different food and amounts of food, even like what it means to different cultures, so crazy.

Melanie Avalon
Exactly. And then like I'm saying in my head, I'm like, I think people should be able to eat whatever they want to eat.

It's like, it's like, yeah, it's like being in a state of freedom and then going somewhere where there's not freedom. And it's just you don't have the same cult, you're just not on the same foundation to understand each other.

Barry Conrad
Even with fasting, Melanie, the whole thing about, well, why don't you just eat with us now? Because we're all eating.

But then for example, doing Destiny, there's these things called cook sisters, which is their South African donuts. And so one of the cast members' moms made these donuts and they brought them into the rehearsal room. Obviously, that was during the morning slash day. I took a couple and wrapped them up for the time I broke my fast. The old me, who used to be very people pleasing, would have said, I guess I'll just eat them because I'll feel bad that I'm not eating with everyone else. But you just have to do you.

Melanie Avalon
I am so good at it now. Like I go to family events all the time and I, I just drink wine. I'm like, yeah, but it, it took a long time to, to get there for me personally.

It sounds like you too, you know, like now you feel comfortable bringing them home to have later. Yeah, one thing you can do, and I've shared this before on the show, but oftentimes people, so you not accepting the, the meal or the thing that was made feels like a rejection of that person's offering of love to you. Cause that's what food often is. It's like an offering of love. So you can decline that food and then provide them an opportunity to give you love in a different way. So, and again, I've talked about this before, but if say they're like, oh, here's this, if your grandmother's like, I made this cake for you, you can be like, you know, thank you so much. I'm, you know, either I'm not hungry right now. I'm, you know, whatever say, but could you make me some tea or like, or, you know, give them like an alternate that they can, it doesn't have to be food. He'd be like, but instead could we like do a puzzle? I don't know. Like if you give them something else that they can then gift you, they won't feel as much like the ring rejected.

Barry Conrad
Yeah, just yeah. I do think for some people, like the emotional intelligence or maybe just it's so steeped in their conditioning that they probably wouldn't be able to see the reason why.

Why can't you just eat it? You know, like it's just hard to explain sometimes to people, you know? It's a constant thing.

Melanie Avalon
This is why you got to just find your fellow internment and fasting person or family.

Barry Conrad
But also, Mel, don't you agree that if you don't actually make a big deal of it and you just stand there drinking wine and you don't bring anything up, most people don't notice. But if you make a big deal like, oh my gosh, I'm so hungry, I can't wait to eat, then you make it a big deal, you know?

Melanie Avalon
Mm hmm. Yeah, I have gone to so many like dinners dinners and not this is typically when I'm going on like a like a this happens a lot with like a biohacking conference when I go to the dinner because I want to go to the party thing party thing and part of it's a dinner. And I mean, again, biohackers are more accustomed to fasting, but I've done this at like non health conferences. I just sit there and I'm like, I'm just you know, I'm not eating right.

I'm eating later or I just drink water and wine and don't make a big deal of it is the point.

Barry Conrad
Yeah, don't draw attention to yourself.

Melanie Avalon
And if they're super concerned and obsessed, that's their problem. That's not you.

All right, shall we answer a listener question? Let's do it. So our first question comes from Teresa and the subject is, can we talk about gas? Love it. And Teresa says, I'm sorry to bring this up but hoping I'm not the only one with this problem. I've always had periodic issues with gas odor like once a week but since beginning intermittent fasting a month ago, it's every single night, all caps. We are talking, husband sleeping on the couch kind of bad. Oh my goodness. She says, I've been to a doctor and have blood work done so I'm not looking for medical advice but just wondering if anyone else has been through this and what the problem was. Thank you so much. And then she signs off stinky in Seattle. Love it.

Barry Conrad
That's really funny. That's hilarious.

Well, Teresa, thank you so much for your question. And don't be sorry for asking any questions. The great thing about intermittent fasting is it's really good for inflammation and weight management and clarity. But it also can come with a period of digestive adjustment. And yeah, that can also mean your gut bugs can sometimes throw a bit of a nighttime party that your partner obviously is noticing. So when you collapse your eating into a tighter window, not only does your body adapt to burning that stored energy, but your microbiome also recalibrates. So if you've filled your meals with high fiber powerhouses like veggies, beans, lentils, I don't love beans, by the way, or whole grains, you're giving your gut bacteria more fermentable substrate. So by day, you're happily digesting. But at night, as the house settles down and intestines take over, those microbes feast and have a nice little gathering and produce extra gas, the result can be, well, more like an acoustic situation that you might not like, that your partner doesn't, your husband doesn't like. So you might try, maybe try sliding your eating window earlier in the evening, maybe. And if you've been breaking your fast, say, around noon and eating till 7 or 8, maybe consider closing shop at 6 PM as an experiment. That extra hour or two, maybe, of daylight digestion could, maybe, reduce overnight fermentation. And another thing is mindful chewing and not just attacking your plate. Well, this is coming, the kettle calling the pot black because I devour my food. But maybe mindful chewing is another underrated tip you might try. And if you take a moment to really break down each fork full and reduce large food particles heading into your intestines, that could help. And even a gentle 10, 15 minute walk after a meal, your final meal could be good. It doesn't need to be like a workout, just leisurely stroll around, could help food transit more smoothly rather than let it sit away and bubble away and marinate. I've heard of people having a scoop of digestive bitters or something like that, a bit of an enzyme supplement even before dinner. And that primes your stomach's acid and enzyme output, which front loading the breakdown of proteins and stuff, which could help too. And if you're suspecting it's FODMAP triggers, common offenders could be garlic or onions or apples, beans. It can be eye opening to keep a simple, maybe like a log or like a little diary for a week or so just to see what you're having. And if it makes a difference to maybe take it out for a little while, jot it down. And you might also spot when you have a lentil salad or a big helping of Brussels sprouts the next night. If it gets noisier or more odorous, then you can maybe rotate or reduce those specific ingredients. Hydration's massive as well, Teresa. So definitely making sure that you have enough water, because a lot of us think we are. But even mild dehydration, which is not intense, but mild dehydration can slow digestion and really worsen that gas buildup as well.

Barry Conrad
So aim to really consistently sit throughout the day or make sure you're just getting enough water in there. Last but not least, I reckon just don't be too hard on your microbiome or get too doubt in yourself.

If your body's adapting to a new routine or a novel routine, that phase could maybe take a little while. So with those little tweaks, those little tips, see if that makes a difference. And I reckon your gut will likely settle down into a schedule. And those nocturnal announcements might dwindle a little bit. But yeah, hopefully convincing your spouse to give you the sofa for a bit of a break as well, and you won't feel so bad. But Mel, what do you reckon?

Melanie Avalon
Oh, my goodness, Barry, that was so, so, like, descriptive. We got little, little gut buddies doing, having their party, making those little acoustic sounds. It's like, it was a vibe. Love it.

And that was overwhelmingly comprehensive and incredible. So I was going to say a lot of really similar things. And so something that I was going to say at the beginning was my first question, if I were to hear this from anybody, would be, do you experience this when you're not fasting? And so the fact that she does like once a week that she's, that it's not uncommon to her tells me that at least at some point, some of the foods that you're eating are the type of food that are creating gas in you. So not the fasting, creating the gas with just the food themselves. And that could be either beneficial or not so beneficial. So if it's being created by quote, good gut bacteria, that gas can actually serve as something called postbiotics. So it actually can have a beneficial effect on the flip side.

If you have a microbiome or some bacteria that aren't so beneficial for you and they're creating problematic gas, that's, you know, slowing things down, creating digestive issues, inflammation, that's not good. So when you, if you're, if that's happening anyways for you, if you're putting all your food into it, like Barry was saying, a concentrated window. Now that's a lot of food to deal with a lot of more potential for, a lot of things are slowing down and completely makes sense that you would be experiencing this. So I love, I love all the suggestions Barry gave. The first one I would give, he mentioned FODMAPs. So I'm really passionate about FODMAPs. I, FODMAPs for a lot of people can be the thing causing digestive distress. And actually they've done a study, they've done a few studies on this. They've found that a lot of people who think they're actually reacting to gluten may be reacting to FODMAPs, which is far more extensive than, than gluten. It's it stands for fermentable oligosaccharide, disaccharide, monosaccharide and polyols, and these are just food substrates that yes, can feed good gut bacteria, and also they can easily create, encourage the formation of gas, digestive distress, all the things.

So I would try, I have recently found this incredible enzyme that's specifically made to break down FODMAPs. So it's called FODzyme. We love them. I love the company too. I've been talking with the company a lot and they're really awesome people. There's no capsules or anything like that. It's just a powder packet and you actually, you actually put it onto your food, it's tasteless, and then it directly breaks down the FODMAPs and the food. And it can be a game changer if you have digestive distress.

So I would definitely try that. It's called FODzyme. We have a code for 25% off, which is incredible. So for that, that's for your first order, go to FODzyme.com. That's F-O-D-Z-Y-M-E.com and use the code IF Podcast. You will get 25% off. I love FODzyme. So I would get that. I would start sprinkling that on your food. I think that will really help. And then I would also, I love all the other suggestions Barry was making.

Melanie Avalon
So maybe eating a little bit earlier so you're not eating all that food right before bed, you know, lengthening your window a little bit if you need. You can also try other digestive enzymes as well. You can try poutine HCL, which is a, that supports your stomach acid. That's going to help you break down protein, because especially if you're not breaking down the protein, that can kind of, kind of like a traffic jam because protein takes a lot more time and energy to digest and enzymes to digest. If you're not breaking down the protein, it can kind of make everything else kind of like get backed up. And now that fiber is fermenting, those FODMAPs are fermenting, you're creating gas, all the things. So I would, I would focus hardcore on digestive support. I would get those enzymes. You can ramp them up if they're not, if it's not working enough, but just one packet might actually do it for you. Those are really the main things.

Basically, I do wonder cause she was asking if other people have experienced this as well. I would be really curious. Oh, that, that is something that I know. I know that, Barry, I think you mentioned this too. A lot of people will have like an adjustment period when they first start fasting and they have more gas at the beginning, but then their body gets used to eating in a concentrated time window. You start producing more enzymes, your gut microbiome adjusts, but if it's not going away, which it seems like it's not, definitely try out the things we were talking about.

So Barry, do you struggle with gas or digestive issues? Do you get like GI issues much? I feel like you're, you have like a stomach of iron.

Barry Conrad
No, I don't, not really. Like I don't, like I rarely do. And this, and if I do, it's usually because I'm sick. So no, not really. No.

Melanie Avalon
That's so amazing. I think I used to be that way. Uh-huh. I mean, well, growing up, I could, I didn't, I don't have memories of having like digestive issues until I got them.

Barry Conrad
Why do you think that changed your-

Melanie Avalon
Well, I got I got food poisoning in 2014. And then that just started off and this happens to a lot of people. There's like a quote inciting incident where something happens, usually it's like food poisoning, some sort of like exposure, something happening is you get really you get really sick. And then you never quite.

Yeah, it's like a journey from there. So but I'm good now as long as I do my my enzymes, my fasting, I know the foods that work for me.

Barry Conrad
Yep. But Teresa, keep us posted. Like, and thank you so much for your question and good luck, but I hope it's not stinky in Seattle anymore.

Melanie Avalon
Yes, I agree with you, Barry. We love all questions. All right. Shall we have our proverbial breaking of the fast moment?

Barry Conrad
A proverbial breaking of the fast moment is about to happen right now, so I'm going to send you the place and

Melanie Avalon
So Barry, what restaurant do you have for us today?

Barry Conrad
So, the restaurant that I have for us today is called Le Bannadon. Hopefully, I'm saying that properly.

It's based in NYC, another New York restaurant, and it's Eric Rippert's Seafood Sanctuary. So, I know that you love seafood, so do I, Mel, offering a refined menu of kudo, sashimi, style tuna, miso glazed black cod, world-class, by-the-glass pours of wine, an encyclopedic cellar of white burgundy, champagne gourish, sous-vise. The vibe is like muted gray walls, vaulted ceiling, and customer-read-inspired art. They create a serene under-the-sea ambiance, which I thought you might like, and this place has maintained a four-star rating from the New York Times for over two decades.

Melanie Avalon
What? Two decades? That's stressful.

Barry Conrad
to maintain. Yeah, that's a long time. Don't mess up.

Melanie Avalon
Amazing. And did you know how we talked about this before? I think we've talked about this before. Yes, we have. We might have even talked about it really recently. I didn't used to like fish.

Barry Conrad
I know, which is you actually have said that before, which is so surprising to me.

Melanie Avalon
Yeah, I just thought about it because looking at this menu, like this would have been so scary to me growing up. Right now it looks amazing.

Barry Conrad
So it's really seafood heaven. And so Melanie, on that note, is there anything, I know that you're not gonna have one thing at least there in the beginning, but what would you like to start with from this situation?

Melanie Avalon
Okay, so it looks like this is a prefix, right?

Barry Conrad
You can download the menu PDF if you want, click on that.

Melanie Avalon
Okay, it's a prefix, which normally I get hesitant, but there's a lot of options on this. So there's the, so we start with the almost raw course.

Barry Conrad
Let's start with almost raw, yeah.

Melanie Avalon
I think I think we're gonna have to get maybe we should get three for the table so that we can or Four for the table so that we can pick I think so too at least three. Let's get three

Barry Conrad
And Melanie, I don't know if you're the same as me, but with seafood as well, I could eat a lot more of it.

Melanie Avalon
Mm-hmm. Yeah. I was actually gonna ask you about that when we were talking about just not getting hungry from, or sorry, not getting full from processed foods. And then last week when I was talking about preferring tougher steaks because they make me fuller, with seafood, it doesn't fill me up as much, even if it's the same amount of calories. Have you, have you noticed that?

Barry Conrad
I definitely have noticed and do notice that all the time it's so interesting how and why that is like why do our bodies you know why does it register differently even the same volume or even the same calories like why same grams and macronutrients.

Melanie Avalon
know what I think it is? I think it relates to my tough steak theory.

Because I've thought about this because with fish, you're never like, you know, because it's like a white meat normally, like a white fish, compare that to chicken or pork or some other land white meat. You don't really eat.

Barry Conrad
It's easier to eat, so in that case we're going to be here for quite a while, so you think we should do

Melanie Avalon
Wait, we're going to wait. You're saying we're going to need more. Wait, what do you think?

Barry Conrad
Yeah be at the restaurant for quite a while and have multiple multiple dishes of things.

Melanie Avalon
On the one hand, it feels like we would be here less because we eat it faster. But you're saying like we need more dishes.

Barry Conrad
to feel full satisfied, yeah. Exactly.

Melanie Avalon
Yeah. Okay. So what are we going to do? Are we going to do are we going to do three orders?

Barry Conrad
I think we should do four. I think you should pick two and I should pick two. Okay.

Melanie Avalon
I wonder how often people do that probably not that much okay I love that okay I'll wait I won't say it yet um there's something I want to point out when we get to it okay so for the almost raw oh what's number two and number three

Barry Conrad
Oysters, yes. My favorite.

Melanie Avalon
So what two are you picking?

Barry Conrad
Well definitely the oysters so i'll do the oyster uni because that seems quite exotic and cool so i'll try that and also the looking down looking down the.

Melanie Avalon
Tuna. The oyster uni is a sea urchin oyster medley. Have you had sea urchin?

Barry Conrad
I actually have. I actually love Sijuan.

There's a place in Melbourne actually that I went to just before starting rehearsals for Destiny and I went with a friend and they specialize in oysters and sea motion. It's so good.

Melanie Avalon
They take all the prickles off, right?

Barry Conrad
To take all the pickles out, it's really, really easy to eat. It's almost like a dessert. Not that it's sweet, but it just melts in your mouth. It's delicious, Melanie.

It's the first time I've ever had it. And it was absolutely incredible. It was so good.

Melanie Avalon
I'm having flashback all the sea urchins on the on the beach. Well, with our little porcupine this.

Okay, so you're getting that and the tuna, you said. Cool. Do you want to read the tuna description?

Barry Conrad
The tuna is layers of thinly pounded yellowfin tuna, foie gras, toasted baguette, and chives.

Melanie Avalon
That's perfect because you know me now I love I love pounding things. I'm like so excited now to like pound all the things in the kitchen. I have so much fun. It's so fun.

I highly recommend everybody get a mallet pounder thing and start doing this.

Barry Conrad
Is your countertop sturdy? It's not breakable, right? Because you're pounding all that.

Melanie Avalon
Yeah, it's not breakable, but it's funny because I do this when I have my meal very late at night and I'm like, are the people below me? I'm sorry.

Okay, I'm gonna get all of this is almost raw. I'm going to get... I think I'll try the Gambaroni Rosso, which is shrimp tartare and lemon saffron emulsion. That sounds good. And the... maybe the caviar.

Barry Conrad
YUM! That sounds great!

Melanie Avalon
Is it Ocetra caviar? Okay. Moving on to the...

Barry Conrad
Barely Touched. I like these titles. Almost raw, barely touched, lightly cooked. Love it.

Melanie Avalon
Yeah, I love it. Love it. Love it. Barely touched. So sensuous. Okay.

What do you... Let me look. I see. Okay. I know. I want the trout, the warm smoked sea trout with verjus fine herbs emulsion. And I think lobster, steamed lobster, kumquat and charred cucumber, spiced shellfish, citrus broth. And with all of my choices, I'm going to get it, you know, plated separately, deconstructed things on the side and then you can have the side stuff.

Barry Conrad
Yeah, I was going to do the lobster for that section, but I'm going to save it for the lightly cooked. So for this section, I'm going to go Black Cod Nobu San, which is miso glazed, black cod, summer roll, citrus, olive oil dressing.

And I'm also going to get the red shrimp, get my shrimp fix, which is seared shrimp, fennel, mousseline, sauce, boula, boula base. Again, listeners, we apologize if you can't pronounce these. We struggle. is the takeaway, but we really love your menu.

Melanie Avalon
We do love and we love the we love the countries that we are completely messing up pronouncing things correctly. Okay, now we are at I'd like good choices, by the way, now we are at lightly cooked.

And there's also this is what I was gonna say earlier, I like that they also have a pawn request and then you can add in, well, interestingly, so you can add in two non seafood items, three non seafood items and then also red snapper. Whoa, it's a whole red snapper and it requires 24 hours notice. Oh, it's for two. Oh, wow. You know me. I love whole fish. Okay, but so what are you gonna go with lightly cooked?

Barry Conrad
So for the lightly cooked, I'm going to definitely go for the lobster situation, which is poached lobster, glazed celesophis, white balsamic tarragon, bernaise, and then I think, well, not I think, I know I'm going to also get a sorted wreck of lamb as well.

Melanie Avalon
I was confirming that sole is low mercury fish. Have you had scape before? Isn't that kind of like a stingray or something?

Barry Conrad
I've never had that, actually.

Melanie Avalon
Oh, yeah. It looks like a stingray. Is it a stingray?

Barry Conrad
That's a Stingray?

Melanie Avalon
I'm looking it up skate versus stingray. They're similar in appearance. So they look different. They look the same Uh, oh Oh, do you want to know a fun fact tell me so Stingrays have long whip like tails with a venomous barb skates have a shorter thicker tail with thorny projections But they don't actually have a stinger skates are Ava par ava paris meaning they lay eggs whereas stingrays are viva paris meaning they give birth to live young What I just learned so much that I did not know but they do look very similar They they look like like if you google it escape it look I would not I would think they're the same thing They look the same to me.

Oh, wow. Yeah I will have the the dover soul Pan seared dover soul romanesco and cauliflower florets toasted almonds soy lime emulsion and Oh It's just i'm just hoping that i'm going to be full enough from all this fish. I think and then salmon barely cooked salmon root vegetables I can't say these words leek truffle something else

Barry Conrad
Mountaineer.

Melanie Avalon
Mm-hmm. Yeah, okay

Barry Conrad
Great. You're not going to go for the red snapper situation.

Melanie Avalon
Snapper is not super low and mercury is the problem. I'm always trying to spread awareness about mercury. And then is there a dessert mini?

Barry Conrad
There is a dessert menu, so we got to go to the go back to the previous page. There's dessert menu there.

Melanie Avalon
And by the way, this was really fun to have like a whole seafood only menu, minus the lamb that you got.

So you don't, so you don't feel like we're, we're like, you know, not speaking what we're talking about earlier with like going with the culture, do you feel like we should not get the lamb because

Barry Conrad
You know what, you're right. Maybe if you're just seeing as everything else has been seafood. Let's just negate the lamb, negate my South African urge to have just meat.

Melanie Avalon
Me too.

Barry Conrad
What are you going to swap it with? I'm going to swap it with the... We should get the skate. No, no, no. That looks creepy. I don't know if I want to eat that.

Melanie Avalon
No, no, wait, Mary, we can't not get the skate now. Wait, you realize we cannot not get the skate. We have to know. Don't you want to know?

Maybe it's like a sea urchin situation where it tastes, you know, I think it's going to taste like a sea urchin.

Barry Conrad
Okay, well, let's let's do it. Let's get this K and try it.

Melanie Avalon
Okay, I'm excited.

Barry Conrad
And then dessert, is there anything catching your eye? There's quite a few delicious.

Melanie Avalon
Can I guess what you want? Sure. Okay. I think you want, let me look. Well, hmm, are you going to get the Peruvian dark chocolate?

Barry Conrad
Yep, that's so, I'm so predictable when it comes to desserts.

Melanie Avalon
which is the warm Peruvian chocolate tart with Tahitian vanilla ice cream.

Barry Conrad
Very plain, but not plain. Your dessert looks amazing. I'm just saying it very simple and just like what wins for me. I love that.

Melanie Avalon
I love that you talk to them like they're listening.

Barry Conrad
No, just in case, like, you know, what if they're like, who are these people tagging us in this thing, you know?

Melanie Avalon
They might be. And then I think, Oh, this is hard. I think.

Barry Conrad
There's at least a couple things that i would get as well.

Melanie Avalon
Are you feeling the, the citrus Madeline? No. Do you like banana?

Barry Conrad
I do. I do like... Yeah, I do actually. I do.

Melanie Avalon
You do. You like neutral do or you like do do?

Barry Conrad
No, I actually do. Like whenever I get waffles and stuff, I always get sliced banana and chocolate stuff. So I do like banana. Yeah.

Melanie Avalon
You do. Okay, so are you going to get the banana toffee?

Barry Conrad
Yep, I'll get the banana and toffee.

Melanie Avalon
banana sticky toffee pudding with bourbon cream anglaise. And do you like, do you like, do you like peanuts? I gotta, I gotta know this so that I can really nail your dessert menu going forward.

Barry Conrad
I do like peanuts, but it's not never going to be my number one, but I do like peanut. I really do.

Like all sometimes I went through a phase of like eating peanut butter out of the jar. Like I love peanut butter and peanuts.

Melanie Avalon
Okay so what was that what you would have picked or what would you have picked.

Barry Conrad
I would have picked the banana toffee situation for sure. Yeah, good job.

Melanie Avalon
Thank you. I'm just looking because I realize there's a chef's tasting menu that's a little bit different.

Okay. For dessert, I'm going to get... Really, it's going to depend on what I like the most thus far and I will get a repeat of that. So it might be maybe some more caviar. Oh, I know what I want. Disregard what I just said. I know what I want because I wanted it from the Bailey touched menu, but I'd already filled up the thing. I want the salmon caviar for dessert.

Barry Conrad
Salmon caviar, there you go. That's pretty cool. I want to go here.

Melanie Avalon
Are you gonna go?

Barry Conrad
You know what I'm all the New York ones are definitely I have to check out because otherwise I wouldn't pick them So definitely it looks pretty good

Melanie Avalon
good. Are you making a list?

Barry Conrad
Yep, I am.

Melanie Avalon
Oh my goodness, amazing. Have you been to one yet that you've talked about since we've recorded? Because I want you to like tell your experience because that will be wild.

Barry Conrad
Okay, I definitely will go to Gimlet, which is in Melbourne, which I'm still in Melbourne right now, and I'll definitely report back here because that was one of ours from the past.

Melanie Avalon
Oh my goodness, so exciting. Okay, awesome. Awesome, well great find. I am like really hungry now.

This was amazing. Listeners, thank you so much for being here. We appreciate you so much. These show notes for today's show will be at ifpodcast.com slash episode 444. That will have a full transcript as well as links to everything that we talked about. So definitely check that out. You can submit your own questions by emailing questions at ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can follow us on Instagram. We are ifpodcast. I am Melanie Avalon. Barry is Barry underscore Conrad. I think that's all the things. Anything from you Barry before we go?

Barry Conrad
No, thank you so much all of you guys for listening and we can't wait to be with you next time.

Melanie Avalon
Awesome. I will talk to you next week.

Barry Conrad
I'll see you next week, bye.

Melanie Avalon
Thank you so much for listening to the Intermittent Fasting podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed.

If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by podcast doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week! 

Oct 13

#443 – The Inertia Of Weight Loss, Exercise To Enter Ketosis, Telling People What They Mean To You, Whole Foods For Satiety, Alcohol And Weight Loss, HIIT And Zone 2, And More!

Intermittent Fasting

Welcome to Episode 443 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, biohacker, founder of AvalonX, and author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine, and Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC

SHOW NOTES


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LINKS

Featured Restaurant: Bourbon Steak

STUDIES:

The effectiveness of self-directed meal replacement-assisted intermittent fasting in adults

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts!

Original theme composed by Leland Cox, and recomposed by Steve Saunders.


Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.


TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)




Melanie Avalon
Welcome to episode 443 of the Intermittent Fasting podcast. If you want to burn fat, gain energy and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, founder of AvalonX and author of What, Win, Wine, Lose Weight and Feel Great with Paleo Style Meals, Intermittent Doctor, singer-songwriter, and creator and host of Banter with BC. For more on us, check out MelanieAvalon.com and BarreConradOfficial.com. You can submit questions for the show by emailing questions at iapodcast.com or by going to iapodcast.com. We would love to hear from you.

Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine. If it's that time, and get ready for the Intermittent Fasting podcast. Hi, everybody, and welcome. This is episode number 443 of the Intermittent Fasting podcast. I'm Melanie Avalon. I'm here with Barre Conrad. Barre, how are you today?

Barry Conrad
Hey Mel, how's it going? I am good. I'm doing really well. It is a sunny morning here in Melbourne on a Saturday and it's been a packed day. I feel like it's already the middle of the day.

It feels like 3 p.m. for me. I've been up all morning doing some brand work and stuff like that, which means like content creation and things like that because part of my job is is doing that as well. So I've been doing that. But Mel, I went to a musical this week. This week just gone.

Melanie Avalon
I know what you went to. I saw the picture and I'm supposed to go, hopefully in a month. I don't have my tickets yet. You went to Kimberly, right? Kimbo?

Barry Conrad
Yeah, exactly. You go into that.

Melanie Avalon
Yes, I was excited to talk to you about it. I want to. Didn't it win Best Musical, I think?

Barry Conrad
I think it did, but I have to say this production was so much fun, and it was directed by Mitchell Beattel, who's incredible. He's like an actor-director.

He actually directed the very first musical I did, which is called Violet. And yeah, it's a feel-good show, because it's based on this girl. She kind of has this, for audience, for listeners, that this girl, she has this rare genetic condition similar to sort of progeria, which makes your body age rapidly. So she's like 16 inside, but she looks and lives like a woman in her 60s. She's pretty intense, but it's just fun, and she falls in love, and it's sad as well. There's tears, there's laughing. It was really fun. You'll love it.

Melanie Avalon
That's a real condition, right?

Barry Conrad
It's sort of called, it's formerly Hutchinson-Gilford-Progerio syndrome, so it's a situation.

Melanie Avalon
And when people have that, do they die young as well?

Barry Conrad
Yes, and I don't want to give.

Melanie Avalon
Okay. Well, I've, I've, yeah, no, no, no spoilers. Although I listened to the, I listened to it. Yeah, I'm just like thinking about what that would be like. That's wild.

Have we talked about this? Do you ever listen to musicals and you read the plot along so it's kind of like watching it?

Barry Conrad
No, I actually never do that. Do you do that?

Melanie Avalon
Yes. For like all the musicals I do. Like when the Tonys come out, like the top, you know, all the ones that are nominated, I go watch them in my head.

Barry Conrad
So you first listen and read them before you go so that you like know what's coming up.

Melanie Avalon
Okay, so here's what you do. This is gonna be a new like hobby for you.

Okay, so you most of them on Wikipedia have the plot breakdown and they include when the when the musical numbers happen. So you so you like read the little bit of the plot and then it'll be like this song, it like says in parentheses, the song. So then you listen to the song, then you read the next little part of the plot, then you listen to the song. So it's like watching it.

Barry Conrad
I think you're, well not I think, I know you're the first person ever that I've met that does this.

Melanie Avalon
Really? Yes. That's so strange.

Barry Conrad
I'm sure there are people that I know that do it, but the first person that's told me that they do that.

Melanie Avalon
Well, it's funny because to me, I thought everybody would do that if they like musicals.

Barry Conrad
Yeah, wow, I didn't know that. Okay, well...

Melanie Avalon
It's really fun.

Barry Conrad
And I actually had no context going into this musical because Melbourne Theatre Company, who's producing Destiny, they are producing this one. That's why we went.

The cast went to it. Oh, cool. Yeah, so I had no idea what it was in for and that's kind of good. Like after a big day of rehearsal, just escape to this like surprise. So I was like really surprised.

Melanie Avalon
I'm trying to think we should switch because I should go to a show where I haven't done this before, which I have done before. But normally I watch it ahead of time, like I said, in my head.

So I should go to a musical blind and you should go to a musical having watched it in your head.

Barry Conrad
You know what, deal, let's do it. And also it kind of tracks that you do that because I know that you don't love surprise, like surprises.

Melanie Avalon
There's, okay, so the reason, well, I know I love, well, I don't like surprises. Okay. Surprises I don't like are people being like, hey, surprise, happy birthday. Here's a whole party and you're not dressed up. Like that's what I don't like.

But surprises if I'm in a safe space of watching a show is totally great. I love that actually.

Barry Conrad
And definitely not a surprise of people turning up to your apartment when you're, you know, just chilling out and, hey, Mel, can we have drinks and food? Like, no.

Melanie Avalon
Nope, nope. So yeah, but you should you should try this the re I started doing it because I wanted to Be what I wanted to see all the musicals, but I can't see all the musicals.

So you have to this is the way you do it and another reason is you know how like songs you like the more the more you hear them and

Barry Conrad
Definitely.

Melanie Avalon
So i get concerned because what if i'm going to a musical and what if it has a song in it that is gonna be my new future favorite song but i haven't heard it yet so the first time i hear it is when watching it so it's not gonna land as emotionally with me so i need to like prep myself and find the songs i really like and then listen to them a lot and then i get to experience it with anticipation of like the song is coming.

Barry Conrad
That's really I love that you're so into it. That's awesome. It's quite like you want it to be an experience for yourself, right?

Melanie Avalon
Yes, yes. Here, here.

The next one I'm going to though, the next, wait, is that the next one? I'm going to the whiz and I actually have never listened to or seen the whiz. So I will not. And I will just go in.

Barry Conrad
Speaking of the Wiz, did we ever talk about Wicked cause you love, you like Wicked, right?

Melanie Avalon
Oh yes.

Barry Conrad
Did you see the movie? The film? What did you think of the film?

Melanie Avalon
It's like the best thing ever it's i think we have to talk to about it about it because i i dressed up like linda went to the theater.

Barry Conrad
That's right, we did talk about that, because I saw the trailer for the next one coming up. That's out? Well, it comes out like November, which I think could be now, depending on what time this comes out.

Melanie Avalon
Okay. This airs October 13th. So I think it'll be in like a month, right? Cause it's, it comes out around Thanksgiving. Yeah. Yeah. We should go.

Barry Conrad
Well, did it actually really imagine that?

Melanie Avalon
being the same.

Barry Conrad
country. That'd be really cool.

Melanie Avalon
You know what's funny about that is it seems so much more approachable that we can do things now and the only, and the criteria is that we're in the same country, like that, that makes you seem so much, it seems so much more possible. Even though you're still really far away. So.

Barry Conrad
not too far away. Also, it's so funny because I was talking to my mom and she goes, it's just so different.

When I used to know that you would just like a hop and a skip across the ditch in Australia because it's so close to New Zealand. But now she's like, you live in New York now and it's just the comfort of not knowing that you're there. Yeah, it's different when you know someone's there, right?

Melanie Avalon
Mm-hmm. Here's okay.

Here's something to kind of tie everything together what the the beginning and then what we just said now and all the things So i'm reading I just finished a book called 12 questions for love It's by this guy topaz adid adi I just learned how to say his name before I interview him adid adidas adiz is a It's by a guy named topaz He did this really cool film project that won I think like Emmys and went to Sundance Definitely went to Sundance. I won a lot of awards and um, he basically went around for a long time and he would have He would record couples having conversations and they would give them these 12 questions that they formulated that Help, I don't know deepen relationships and all the things spoiler the last question Is it the last question one of the last questions involves Like what would you say like what would you say to somebody? Like what do you really want to say to somebody? Um, the thesis was basically that we wait for really intense moments like When somebody's dying or when we're not going to see them again to say these really profound deep things We want to tell them and he makes the case we should be telling people things All the time and not like wait for really intense moments.

How do you feel about that? Whoa things got really deep

Barry Conrad
Yeah, real deep, real quick. No, I actually, funnily enough, when I was watching Kimberly or Kimbo, that's like a massive part of, you know, thematically what it's about. So it definitely, I agree, you know, like, why wait till if you know you have a time to, well, to be, to be fair, we all are, which sounds morbid, we're all dying every second, right?

Like, you know, like, it's, it's fine. So why? Just because we don't know the time, why do we wait? Like, why do we do that? I try to, really tell people how I feel. Maybe I don't always succeed, but I definitely try to live in the moment and try to, you know, compliment people or tell them how much they mean to me and things like that. I think why withhold that? I really think it's important. What do you think?

Melanie Avalon
Yeah, I agree. I feel like I try to do that too. My question for him that I want to ask, and I have a lot of questions for him, and I'm going to be really, the whole book is about how we ask the wrong questions. So I'm going to be very self-aware of am I asking the right questions in this interview?

But in any case, it's like how big of declarations are these? And can you do those too much? You know, like, I don't know, I wonder if there's a difference between telling people how you feel and gratitude and things like that, versus these really intense things that we say for like people's deathbeds and when they're leaving and things like that. Like, can you say those too much though? Like maybe, you know, I want to know, I just want to think about it.

Barry Conrad
I do think that it's about reading the room and knowing the relationship you have with someone. If you're close enough to someone, if you count them like a real friend, which typically for me, I only like to have real friends. I mean, obviously there's acquaintances, but if someone's a friend, I'm not going to withhold. I think you're awesome.

You really bring a lot of meaning to my life. I love hanging out with you. We have such a good time. Things like that. I mean, I don't know how much more grand it gets unless you're in love with someone or someone professes their love for you or something like that, but I think there's nothing wrong with just read the room and tell people how you feel based on the temperature of your relationship and the depth of your relationship.

Melanie Avalon
I agree. I think we should have another podcast where we talk about where we do these sorts of topics.

Barry Conrad
Yeah, I think I think as well because it's so funny because when I left Australia, certain people, even just friends that maybe aren't as verbose or descriptive with your language, they really like confessed all these things to me about how they feel. I'm like, oh, thanks so much.

Not that it's insulting that they waited that long. It's just like, oh, I didn't realize that. Thank you. It really means a lot. Why do people do that?

Melanie Avalon
Why do people do it right before they leave? Or why do people not tell people?

Barry Conrad
You know, a lot of people do it right before you leave it.

Is it because you think it's like a sense of like, uh, finality, like you won't see them again or it's, it's so sad in a way, bittersweet.

It's nice and sad, you know.

Melanie Avalon
Yeah, I think so. I think it relates to what your mom was feeling where, you know, I think we take things for granted when they're right there, but when they're not going to be right there anymore, then we have all these realizations of how much it means to us.

Barry Conrad
Do you say things to, do you often tell people, quote unquote, deep things also like, what does deep mean? That's so interesting. We need.

Melanie Avalon
I feel like I feel like like you I mean I feel like I tell people I mean a lot I mean I really value you I love our friendship and our hosting

Barry Conrad
Listeners, I will always say this about Melanie Avalon. She is so generous, not just as a person, but with her words, with her accent. She's just very thoughtful and it's not just because we're co-hosts. She genuinely is a great friend and just very, very, very, just a beautiful spirit.

And I think there's, you know, that's the kind of friends that you want in your life. People that are genuine, not just lip service or just like it's contextual or situational, you know? So, value too, Mel.

Melanie Avalon
I echo all of that back to you. That's something that I just have thought is so amazing about you for so long.

Yeah, how genuine you are and kind and real and you show up and committed and just a good human being. So, yes.

Barry Conrad
Love all around!

Melanie Avalon
Love all around. I know. Well, that was a deep opening to the show.

Barry Conrad
That's a deeper one, but a good one. And also this is, you know, hopefully this like emboldens you to do this. Tell someone today how you feel about them in a good way.

Melanie Avalon
I think I should start a new habit. How do you feel about this? What about every day? We just tell a random friend, not like a random stranger, but...

Barry Conrad
the store at Whole Foods, hey.

Melanie Avalon
Yeah. Well, think about it because they say that, okay, here's my thing. They say that a person can maintain what, around like 300 relationships at any one time. That's almost a year's worth of, although that might include people you don't want to reach out to.

But my point is once a day, you could reach out to somebody and just tell them how much they mean to you. If it wouldn't freak them out.

Barry Conrad
I think that's a great idea and that, you know, it's a good reminder. I want to do that. I'm going to do that today after we finish.

Awesome. I didn't ask you how you were, by the way. I'm great. Okay, good.

Melanie Avalon
I can catch you up more next week if you like. There's some things. Sounds good. Should we jump into some fasting related things?

Barry Conrad
Let's jump right in.

Melanie Avalon
Awesome, awesome. Okay, do you have a study to start us off with?

Barry Conrad
So I have a study this week and it's called the effectiveness of self-directed meal replacement assisted intermittent fasting in adults.

Melanie Avalon
Oh, that's a cool title.

Barry Conrad
Yeah, it was carried out at the evidence-based medicine center, Department of Preventative Healthcare and Department of Clinical Nutrition in China, and their eight-week trial was published in the BMC Complementary Medicine and Therapies in 2025, so pretty recent. And the situation is that they recruited 126 adults, average age 35 and about three-quarters woman, all carrying a BMI of around 26.6 kgs per meter squared. So everyone had a stable weight history and signed up wanting a sustainable way to shed kilos, which a lot of people come to intermittent fasting for.

So the researchers split them into two groups. One was they followed a balanced calorie-controlled plant every single day, so roughly 1,000 to 1,400 calories of whole grains, lean proteins, fruit, and vegetables, and aimed for about 10,000 steps daily. So pretty simple. The other group did the same on most days, but on Tuesdays and Fridays, they swapped breakfast, lunch, and dinner for a powdered shake, totaling around 800 calories. So, you know, mix-up blend situation. On the non-shake days, they returned to the 1,400-calorie target and the 10,000-step encouragement, matching the first group. And the findings, Mel, was after four weeks, the shake and fast crew had lost an average of 5.1 kgs, about 6% of their starting weight, while the straight diet group, just eating whole foods, dropped roughly 2.8 kilograms or about 4%. So that early drop can sort of feel like a win on week one when the scales barely budge. So fast forward to eight weeks, and the shake group averaged about 6.6 kgs, lost around 8%, whereas the diet-only group sat around 4.1 kgs. So it's super interesting, because when the researchers modeled weight loss over time, they found that sticking with the plan week after week was the biggest drive of success. So in other words, whether you're having shakes or real meals, the underlying thing here is consistency was far more important than the specific strategy. The meal replacements did speed up on the early weeks, but steady effort kept both groups moving downward on the scale. So body composition data showed both groups lost fat mass and reduced visceral fat around the waste, which we love. And the shake and fast group saw a slightly greater percentage of fat loss, about 17%, compared to 15.5%, while preserving most of their lean muscle, which I love too. The balance matters because you want to keep strength and energy when you're losing weight, not just hollow out the muscle. And metabolic markers also improved more quickly in the meal replacement group. So fasting blood glucose, total cholesterol, triglycerides, and liver enzymes all trended downward with more magnitude, and both groups experienced healthier readings by week eight. So what does this mean for our listener's mouth, for example? If you're keen for an early win, maybe you've hit a plateau, or maybe you want to get a bit more momentum in that first month, maybe pairing fasting with some high protein balance shake could take decision fatigue out of some of your meals.

Barry Conrad
On the other hand, if you prefer whole foods and you're confident with that situation and can hit your calorie targets and macros without the shakes, that's still great too. And at the end of the day, whether you're blending a shake or plating up your animal protein, like Mel and I, the real superstar is the consistency.

So just keep showing up, stick into the plans, stay on the course. Mel, what do you think of this study?

Melanie Avalon
Okay, so first of all, super cool that you found this. So to clarify, the group that was doing the Tuesday, Friday, quote, fasting, they were given a shake of 800 calories that day on those days?

And so were they, could they have it at any time throughout the day? Like was it a fasting window or was it just that on that day they were given an 800 calorie shake?

Barry Conrad
They didn't specify the time for that. They just said, on Tuesdays and Fridays, they swapped breakfast, lunch, and dinner for a powdered shake.

That sounds like it's just a non-fasting day then because breakfast, lunch, and dinner.

Melanie Avalon
Okay, they so they were given the meal replacement shake and each serving was 47 grams of powder. So it was 200 calories ish, 12.3 grams protein, 26.1 grams carbs, 5.2 fat.

Okay, so I guess they were given it. So this is what's so interesting is the word fasting. And we've talked about this before in prior episodes, how people use word fasting to mean all different things. Because it looks like in this study, they were calling it like a five to intermittent fasting thing. And so the fasting days, the two days were really just a really low calorie 800 calorie day with made of shakes. So I okay, what I like about this is I like the some of the takeaways and I don't know if they pointed this out in the study or if this was you concluding this, but I do agree that having especially for people who are not seeing changes and are having a lot of decision fatigue about what to do, doing something like a super buttoned up shake, where it literally just locks you in to that low calorie day. I think that actually is can be really helpful for people, especially if they want to try this where they're having the two days with what doesn't really surprise me that much is that they did like lose more weight and everything because they were having two days where they ate, you know, a lot less calories than than the other group.

Barry Conrad
Yeah, definitely. It's more controlled. I mean, those shakes are very, as you said, buttoned up. There's no guesswork.

So it's very much the same, whereas if they were doing different volume shakes each day, it'd be different again. So it is very controlled in those days, the shake days.

Melanie Avalon
They titled it, you know, self-directed meal replacement assisted intermittent fasting. So I, I wonder like what they were trying to prove, like that, that people do well with meal replacement shakes. You know?

Barry Conrad
I think what we wanted to compare will definitely says how much both of them both groups lost fat mass and visual fat which is really good and only that first week. Was the biggest step for the shake the shakers let's call them the shakers and then after that afterwards it sort of evened out towards the end.

Melanie Avalon
Yeah, which I love that point as well, because this is actually a reason because people will say that you shouldn't do like really extreme diets and like short even short term, you know, like these, these fat loss protocols like doing extreme calorie restriction. Whereas I think for a lot of people having an initial win at the beginning can be very motivating.

Like some people need to like to get out of the rut that they're in, they actually need to do something extreme where they see, even if it's like water weight on the scale, where they see something that gives them momentum because inertia is everything. So if you're stuck in the inertia of not being able to make change, it's really hard to commit to a new pattern. And then on the flip side, in support of what you're doing, if you get a bigger whoosh at the beginning of weight loss, by doing something a little bit more quote extreme, that inertia can keep you going to, you know, stay on a new paradigm that continues to help you lose weight, even if it slows down.

Barry Conrad
I agree. And for example, Mel, I'm going to be doing a sort of aggressive cut after this weekend, personally, because by the time this airs, my play would have been done by then, but the character has got to be pretty lean.

He's 24 years old. He's a university student on the run. So I'm going to be doing a pretty aggressive cut after this weekend. I'm enjoying the trinkets this weekend, but after that I'm going to go mainly protein for this coming week only, and then kind of go low carb again after that. So it's going to be a challenging week, but it's just short term to drop that extra body fat and wait for the character.

Melanie Avalon
Okay, so a few questions. One, right before you're gonna start it, are you gonna have like an all out feast?

Barry Conrad
Absolutely. So today, actually, after we finish recording, I'm going to today is going to be my feast day.

Melanie Avalon
day.

Barry Conrad
Yeah, it's a day.

Melanie Avalon
Yeah. And what are you going to, yeah, what are you going to, are you, are you going to have things like what are you going to have?

Barry Conrad
I'm just going to have whatever I want like I bought I got some pizza bases and I make some pizza maybe I'm going to have some chocolate I'm just going to have what I feel like having and I just have to remind myself that it's not an emergency if I if I forgo the things that I love for a short term. You know for a short time so it's for a reason so I'm I'm excited and also you know I love food so much I love my trinkets so it'll be interesting to see how I go mentally we'll see.

Melanie Avalon
And when you do the, the basically protein only, are you going to be eating like lean, like lean meat? Like what are you going to be? What do you think you're going to be eating?

Barry Conrad
I'm going to have lean meat for sure between five and ten percent, you know, fat, lean meat, chicken, beef, Greek yogurt, I'll do Greek yogurt as well, even though that has some fat in it because it's a lot of protein in their eggs. So I'm really going to, I'm going to go for it.

I haven't done this in a while, so, and also we have, yeah, it's full on days, so wish me luck and I'll keep you posted.

Melanie Avalon
It's kind of, it's so interesting to me because there is the missing of the, as you, you know, you say the trinkets and stuff. And at the same time, I like, I so love all those foods you just mentioned that I get excited at the idea of like just eating tons of lean meat. It sounds good.

So it's like you're like seeing changes, you know, at the same time. Wow. You have to, yeah, keep us updated. I will. Well, awesome. Fine. Any, any, are you going to have any days of protein of these meal replacement shakes?

Barry Conrad
Absolutely not. You know, I think it's great. It's great. If people want to have shakes, I'm all for that. For me, I just prefer to eat. What about email? I just like food, like eating food.

Melanie Avalon
Yeah, if I had to choose between, I mean, think about this, like 800 calories of a shake compared to 800 calories of like chicken, I would be so starving with the shake. And the chicken, you can get a lot of chicken for 800 calories, even steak.

Yeah, I liquids don't fill me up. They just, they don't fill me up.

Barry Conrad
They just frustrate me.

Melanie Avalon
Yes, me too. Yeah, they're like the worst teas. I just can't. I cannot.

Barry Conrad
Yeah, so the answer is no.

Melanie Avalon
I want to know though, listeners, do some of you guys get full on shakes? Cause I feel like some people, it works for them.

Barry Conrad
And to be clear, we're not slamming or hating on shakes at all. That's great if that works for you. It's just, we just prefer to sit down and feast away on and chew away on food.

Melanie Avalon
I actually even, this is really going down the rabbit hole tangent, so I apologize to listeners, but should I even say this? I have realized that I feel more, okay, because I love, as you know, eating my steak. And I love trying all different types, like grass-fed beef, and I also love bison. I love like Maui Nui, like I love red meats. And I like different cuts, but I really like lean cuts. I've realized that tougher cuts are more satisfying to me, because like a filet mignon, it just melts in your mouth. It feels much more easily digestible. I don't feel like I'm like working through it.

And so I have recently discovered, I think I might have told you about this, I have round steaks, which is a special, it's a certain cut from beef. And it's cut like a steak, it looks like a filet, it's super lean, probably even leaner than a filet, but it's actually really tough, but it's not fatty. So if you cook it right and like mash it with a hammer, you can tenderize it, but then it still requires work to like eat it and digest it. And I find it more satisfying.

Barry Conrad
You were telling me about this!

Melanie Avalon
I think I did, yeah. I don't think I mentioned that it was more satisfying though.

I think I was just trying it for the first time, but I've been I've been doing it now and I've decided it's more satisfying for me than a filet mignon.

Barry Conrad
Do you think it's the action of just chewing like the physicality of it?

Melanie Avalon
I think so. I think like, and this is why I thought about it, because with the shakes, there's something about just, even if it's the same amount of calories, not having to chew it and digest it and it just going straight into your stomach does not give me that full feeling, which actually next week I have a study about this a little bit, so.

Barry Conrad
Really? Oh, can't wait.

Melanie Avalon
Yeah. So how about you? Do you feel like if, if it's a tougher cut of steak, that it's more satisfying? Oh, I just like, yeah.

Barry Conrad
I like, in general, when I eat, I like to chew and, you know, like work my way through it. Not just, not like have a soup, like there's a time and a place for a soup.

I love soups, but when I'm eating, I want to really eat and just like, you know.

Melanie Avalon
Exactly and I tried for the first time a bison filet mignon the other day and it was the most it was so delicious so tender but it was so tender that I was like I need more I need I gotta chew this more I need more. So listeners takeaways from this is maybe if you want to make your meals more filling I'm not saying to go by eye of round and and tough cuts of steak but favoring whole foods and things you actually chew probably the way to go there.

Okay, shall we jump into some listener questions?

Barry Conrad
Let's do it. So the first question we have is Andy on Facebook says, love the podcast and I've listened to every episode. I've been IFing for about one year and it's been a game changer for me. I've never been truly overweight but was very inflamed and just felt sluggish and foggy prior to starting, even with working out. I love the energy and mental clarity from fasting.

I typically do anywhere from 16.8 to 22.2, depending on the day and what social activities I have going on. I have a number of autoimmune issues. So I have fully embraced the quote unquote health plan with a side of weight loss philosophy. I found myself having a glass of wine when I am a few hours into my fast. I only drink dry farm wines as I am obsessed, obsessed in capital letters and don't think I could ever go back to conventional wine. I'm not in denial that this is breaking my fast but I can't help but wonder how much is it really setting me back? Especially if it's low in sugar, is it just setting back the clock while I am metabolizing the alcohol? I also exercise mostly spin class, running and weights. So on that same token, how much does exercise speed up the process of getting into ketosis and obtaining those amazing benefits and all that energy? I can tell the next day after I have the wine that I don't kick into ketosis quite as early as usual but wondering if there's any science behind it. Thanks for all that you are doing to empower people through this way of life. Melanie, what do you reckon?

Melanie Avalon
Awesome questions Andy. Okay.

So this actually made me think of something to ask you Barry. What was it? Oh my goodness Oh, I was gonna say you doing your Your protein only thing for how long did you say you're gonna be doing that?

Barry Conrad
I'm going to do like initially this week definitely straight the whole week and then the next week super low carb.

Melanie Avalon
So you know what you'll be cutting out? Well... Oh, wait. I don't actually... I don't know what you're about to say.

Barry Conrad
Are you about to say, are you going to cut out wine?

Melanie Avalon
Oh no, I was assuming you're keeping that and are you cutting that out.

Barry Conrad
No, definitely not.

Melanie Avalon
we'll talk about that in the question. I was going to say nightshades. Remember how I think last episode or the episode before we were talking about nightshades?

Barry Conrad
Potatoes, yep.

Melanie Avalon
And I was saying like, what would it be like if you didn't have them? I wonder if you would notice anything.

Barry Conrad
Yes, like tomatoes and potatoes and stuff.

Melanie Avalon
Yeah, so you're gonna be cutting that out. Well, I thought about it because Andy was talking about cutting out, or how, and I don't know if it's a boy or a girl, so they were talking about how they cut out, or sorry, how they experienced reduced inflammation from fasting.

I was just thinking, I wonder if you'll notice anything from cutting out other foods that you might not realize. I'm just curious.

Barry Conrad
Yeah, I mean, I definitely think regardless of whatever other carb, I think me sticking to mainly protein, it's good. I know having done this before, even after the first day, I'm going to drop a whole lot of water away, you know?

Melanie Avalon
Oh, I bet. Yeah, definitely. Okay. Well, we should talk about the wine.

So it works well, because Andy was asking about that. First of all, Andy, so happy that I have has been such a game changer for you. And that you're seeing all these, you know, benefits with the brain fog and feeling sluggish and, and the inflammation and the autoimmune conditions and all those things. So yay for that also yay that you love dry farm wines. We obviously love those around there around here they are, they're organic free of pesticides, lower alcohol, low sugar, listeners can get a bottle for a penny at dry farm wines.com slash if podcast. Okay, to answer your question about alcohol and fasting and is it setting you back. So there's a few different things here. Basically, when your body, when your liver is processing alcohol, alcohol in the priority list gets first priority. So when you have different macronutrients in your body, you know, fat, carbs, alcohol, protein, alcohol is what the liver immediately goes to to process. the liver is also responsible for creating ketones. So while it's processing alcohol, it's not going to be creating ketones, which would be from the fastest state. Of course, it wouldn't be doing that anyways in the fed state, but that does stop that process. And then on top of that, this is really interesting, alcohol actually depletes glycogen, liver glycogen, which is the stored form of carbs in the liver. So there's a little bit of an irony here in that, yes, by having the alcohol, that does add, quote, some time because now your body is going to shut off whatever ketone production it was doing. It's going to process the alcohol. It's going to focus on that before really processing your food. So that could elongate the amount of time that you enter the next day. Interestingly enough, the alcohol possibly depleted more liver glycogen than you would have without it. So you might, once you get through that elongated entrance to the fasted state, more quickly enter the fasted state because of the depleted liver glycogen. I'm not going to say it's going to make you enter fasting sooner. I'm just saying it has a really interesting relationship with liver glycogen. So yes, it probably will extend your entry into the fast the next day, which you said you realized because you said that you said you can tell the next day that you don't kick into ketosis quite as early. The reasoning will be for all the things I just discussed. As far as can you have this, how much is it really setting you back? There's so much context here because I think oftentimes people add alcohol or wine or whatever they're drinking to their diet and then they might not make as good food choices along with that. And so the question is, was it the alcohol that was the problem really setting you back or was it the changes in what you were eating with alcohol that was setting you back? If you are, and this is my, just from what I've researched over the years and years and years, studies pretty much, it's interesting because women specifically when they add especially wine to their diet, that's correlated to weight loss.

Melanie Avalon
That could be because women tend to replace what they're eating with what they're drinking rather than making it an add-on. If you are, as far as is it setting you back, I would just look at the literal real results of what you're experiencing. Are you not losing weight like you want to? Do you know as if you look at what you were experiencing and then what do you experience when you add the alcohol and what do you experience when you remove it? I don't think it automatically sets you back massively.

There's also, if you're drinking dry from wines, you're drinking really polyphenol rich wine and quite a few compounds in wine have actually been linked to fat loss and burning fat. There's a compound in wine called PCA-tanol for example, it's a polyphenol and it's been shown, this is in rat studies, but it's been shown to actually inhibit the formation of new fat cells. There are other polyphenols in wine which may be contributing to a beneficial inflammatory state and a fat burning state. And then on top of that, alcohol itself may have a thermogenic effect and actually make you burn a little bit more calories. So I said a lot there, but basically you really just have to see what you're experiencing and is it something that you want to tweak and see how it affects you? I know for me, I can and I could historically lose weight. I have lost weight, a lot of weight historically and I was drinking all during that. I didn't cut out wine. That was not something I ever really cut out to lose weight. I focused more on the food choices and making healthy food choices and doing the fasting. That's because that's what works for me and that's what I like. So you have to find what works for you and what you like. Before we get into the second one, Barry, dying to know your thoughts. Also, you can elaborate on why or why not you would cut out wine while you're doing a cut.

Barry Conrad
Yeah, it's so interesting. And this is a great question, Andy. Back in the day when I was really into the bodybuilding side of things, like just the not doing bodybuilding, but just like the techniques and getting ready for shoots and stuff like that. I know that drinking red wine was this hack that people would talk about to dehydrate you before shoots and things like that. So I don't do that anymore. Or I don't really know if that's even works that well. But I mean, I've never really, the only time I cut out wine is when I'm preparing for a test, like blood test or stuff or something like that, or something medical. But other than that, I drink pretty regularly. If I have something on the next morning, early, I typically won't maybe drink too late. I do definitely agree with you, Andy, that I feel that I enter ketosis later in the next day, for sure. Like today, for example, I feel like I'm not quite kicking. I don't feel the same because I drank last night quite late. So I agree there. But I'm not going to cut out wine completely. I may limit my wine, be mindful of it rather than drink too much of it. But it's definitely not something I'm willing to give up during this cutting phase.

Melanie Avalon
I think it makes it much more bearable too. Yeah.

Barry Conrad
I can still have my meat and my wine, you know, it's like I still feel like I'm feasting.

Melanie Avalon
It's kind of like honestly like I think the original carnivore diet there was that diet it was like let me find it It was like it was basically you like drank and ate meat

Barry Conrad
That's a thing? Well, that was the origins of it.

Melanie Avalon
Yes.

Barry Conrad
I do think that even now, colloquially, a lot of people still believe, and I talk to so many people about this, and they're like, yeah, I'm trying to cut back wine because I just gained weight, and it's not the wine, it's what you have with the wine, and that's something that people still don't really understand. They think the wine is making them fat.

It's usually what people might eat alongside that. That's what I really think that.

Melanie Avalon
I agree and it's interesting. I actually was recording an episode this week and the topic of alcohol came up and the person said that anybody who tries to defend the health benefits of wine or alcohol is an alcoholic. And I was like, that's a big jump. That's a big thing to say.

And I think it's just such a sensitive topic and people have different relationships with it that it can be hard to look objectively at what actually is doing what in the context of things. Because I think the biggest factor is the food that you're eating. I don't know why I can't find this diet. There was some diet, there was like a book written, I think it was like in the 1800s and they basically, you basically like ate meat and like drank alcohol. And that was like the weight loss diet.

Barry Conrad
I'll be doing the diet mel i'll be doing i'll be full.

Melanie Avalon
I mean, I did that basically for quite a while, a while ago. Andy also wanted to know, with exercise, spin class, running weights, how much does exercise quote speed up the process of getting into ketosis? That one I can much more confidently answer, which is yes. So exercise is definitely going to help you get into ketosis faster.

It is true that if you're doing really, really high intensity exercise that actually is, it's fueled more by carbohydrates. It's a different energy system in the body, and it actually can turn off that burning. So that's something to keep in mind. So if you really want to expedite the process into the facet state, and you probably don't want to be doing a lot of high intensity exercise only, you would want to do something like high intensity interval training, where you're doing short bursts of high intensity exercise, because that's going to help deplete that glycogen pretty quickly. But it's not going to turn off your fat burning system, if that makes sense. But doing moderate exercise, definitely doing things like weights, all of this movement is definitely going to help you get into the whole state faster. You're going to burn through glycogen faster with cardio. With strength training, you're going to increase your insulin sensitivity. It's also going to help promote your muscle while fasting. So that's good. That's going to help just everything in general. So yes, yay, team exercise. I just wouldn't do only high intensity cardio only. I would do moderate, low and a blend with strength training. How about you, Barry?

Barry Conrad
I 100% agree with this and Melanie actually speaking on that at the moment I don't know if you've seen but on instagram and tiktok there's this trend of if it's a trend but. A lot of these pts are saying what people think burns fat and they'll split the screen and on the one side of the screen is people sprinting. And running for miles and miles and miles and the other side of the screen is people walking on an incline. Just walking and they say the walking burns more fat rather than just like high intensity.

You know what I mean so it's really interesting that that that's this new thing right now so that speaks to what you're saying about if you're just doing a high intensity all the time it doesn't necessarily mean you're going to. You know go into katosas quickly.

Melanie Avalon
And not only does it, and I'm glad that social media is catching up to this idea, but not only does it not burn fat, it actually turns off that system. It kind of locks you into a glycolytic state where you are preferring to burn carbs rather than fat.

So doing that lower exercise or lower intensity exercise like zone two is definitely the way to go to burn fat. With the exception, like I said, that high intensity interval training, those short bursts, you're actually going to get max benefit there without the problems of locking you into that state and turning off that burning.

Barry Conrad
Melanie, I think it's also, I really believe it also ties back into the whole paradigm or thought that people think, you know, the more effort you put in, the more calories you're burning because it's calories in, calories out, it doesn't work like that. It's not just calories.

Melanie Avalon
Exactly. And it doesn't have to be that hard.

If you're smart and you know how to hack your biology with things like fasting, like timing of food, the food choices you make, the type of exercise you do, you don't actually have to suffer that much to move toward... You don't even have to suffer, I don't think, if you do it right to move towards, say, the body composition you want. And then I was gonna make a joke, I was gonna say, and throw in like a GLP1 agonist and now you're off to the races.

Barry Conrad
I do think even Andy, for me, I do 35 minutes of weight training three times a week, and then I do the treadmill on an incline for maybe 30 to 35 minutes, not fast, just walking. And that's it.

I'm not out there trying to die and sprint my brain off. You know, I do hill sprints, like short bursts, but I don't run for miles and miles and miles. I just don't. And you look...

Melanie Avalon
amazing!

Barry Conrad
Well, that's very kind. Thank you so much.

Melanie Avalon
I can never say the phrase. What is it? You walk, you walk the walk, you don't just talk the talk. I try. All right. Well, speaking of, shall we break our proverbial fast? Let's do it.

Barry Conrad
I'm so excited.

Melanie Avalon
I'm excited because last time I was bringing the restaurant, I couldn't find the menu because it wasn't up yet and I now have it. So let me get it.

Barry Conrad
I'm excited for this.

Melanie Avalon
I just realized it's a chain, but it's like fancy chain. Have you been to a bourbon stake before?

They're in Charlotte, Delray, Las Vegas, Los Angeles, Miami, Nashville, New York, Orange County, Scottsdale, DC, and then their new location, Orlando.

Barry Conrad
I have not yet, but I do know of, I have seen this place online, not, not the specific one like menu, but I do know of it.

Melanie Avalon
Okay, so I was going to do the new one because one of my favorite restaurants at Disney World used to be Shula's, also a chain, like a nice fine dining steakhouse at the Swan and Dolphin. It's at the Dolphin Hotel, and now it got replaced with Bourbon Steak, which is run by Chef Michael Mina. He has a lot of awards. I think he has Michelin stars, I believe.

Should we do the one in Orlando, or should we do the one in New York, because you could actually go?

Barry Conrad
I think you should choose the one that you want to go to.

Melanie Avalon
I wonder if it's the same menu.

Barry Conrad
Because which one's the newer one? Because the one if the newer one is a bit more festive and has new additions, you know?

Melanie Avalon
Just open so we can do that. That's the one in Disney World.

Barry Conrad
which is very Melanie coded, there we go.

Melanie Avalon
why I picked it. Like I said, it's replacing.

And this is really cool. So this speaks to a restaurant that clearly had, I think, a good environment because I read that the previous staff that was at Shula's, they all stayed. And they're the staff at this new restaurant. Isn't that cool?

Barry Conrad
That says a lot about the management of the restaurant.

Melanie Avalon
They said it was 100% retention of the staff.

Barry Conrad
Wow, that's amazing. So I just sent you the Orlando. So I'm looking at the dinner menu right now. It's loading. Yes, yes, yes, yes. I see things that I like already.

Melanie Avalon
too. Okay. Oh my goodness. The first thing on the menu.

Barry Conrad
Exactly. I think you tagged me. There was one of the people on Melanie's Facebook group.

Melanie Avalon
I did, yes.

Barry Conrad
Was talking about cuz i think your question on is like what's your favorite meal something like that and they said raw oysters and other things and Melanie was like. What's good about that i think she tagged me and i said like it's the best thing what's not to love about something like that it's like yes someone backs me up finally.

Melanie Avalon
blows my mind, blows my mind. So well, here we are.

So bourbon steak, and let me just read about it really quickly. It's an ode to the traditional steakhouse, celebrates the details that make meals memorable from perfect seers, tableside, old fashioned, to shared sides, milestone moments. Again, it's that acclaimed chef. And yeah, and the new one is at the Dolphin at Disney World. So to start things off, and apparently, because I've been reading reviews of the one at Disney World, apparently instead of bread service berry, they bring out three different french fries and three different sauces.

Barry Conrad
Let's go. That sounds awesome. I love that idea.

Melanie Avalon
Yeah, I'll hear I can tell you exactly what they bring up because I have the article. It was, so they bring out a medley of truffle aioli fries with a truffle aioli, regular herb fries with regular ketchup and then paprika fries with housemade bourbon barbecue sauce.

Barry Conrad
Oh man, that sounds amazing. I want that right now. I know. And you can have them all. That's such a good idea. Have you ever heard of a restaurant bringing out fries instead of bread service?

Melanie Avalon
No, but this actually reminds me of a restaurant I'm going to do in the future that relates to this. That's in LA. I'm going to make a note. Maybe I'll do that next time.

Okay. What would you like to start?

Barry Conrad
I'm definitely gonna go for the shellfish platter, which has oysters on the half shell, chef's ceviche, half main lobster, shrimp cocktail trio of sauces. We have to do caviar as well, right? Gotta do it.

Melanie Avalon
Yes, definitely. And I want the Oh, they have king crab. I think I like the shellfish potter too, but just the lobster and the shrimp.

Barry Conrad
I can have the rest.

Melanie Avalon
Yes, yes. With a trio of sauces. And you can have all the oysters.

Barry Conrad
There's also the cells and appetizers, so that's like a different compartment in my stomach, so we need to go to the cells and appetizers for the second part of the beginning situation.

Melanie Avalon
What are you going to get from this?

Barry Conrad
I'm going to forgo the salad because I feel like I want the room for the fries. I'm going to do the bacon wrapped scallops with Bing cherry turnip Marcona almond Madera and illusion.

I've never heard of a bacon wrapped scallop before, have you? Wait, really? No, just like scallops.

Melanie Avalon
Oh, that's very common here.

Barry Conrad
Oh, is that an Americanism?

Melanie Avalon
I guess so. This is so interesting.

It's so interesting things I wouldn't... I don't know if it's American, but I guess it's not Australian. Yeah, that's very much a thing here. It's so good too. And it's perfect as an appetizer because I eat a lot of scallops, so I don't like to get it as an entree. But in an appetizer version with bacon, yes.

Barry Conrad
But I'm trying to picture milk is because scallops are quite tender. So the bacon would need to like tenderly be wrapped around. Like, how does it work? How does it.

Melanie Avalon
Yeah, they just do it. Yeah, they just do it.

Barry Conrad
Okay, what are you going to have? What looks good to you?

Melanie Avalon
I also want the bacon wrap scallops. So maybe, maybe we can share or get, wait, what's the other one?

Oh, that's truffle. Yeah. Or maybe the tuna tartare, but I, yeah, maybe the tuna tartare. I just get nervous about the mercury, but, and then for the actual meal,

Barry Conrad
Oh my gosh, this looks amazing. Oh, wow. I'm looking, uh, I'm going to have to go with, uh, the strip, the a five strip line specialty cut from Japan.

Melanie Avalon
You know, that's not a lot of meat. It says it's four ounces.

Barry Conrad
So if I, oh yeah, it's not going to be that big. I'd like to get like a side of that.

Melanie Avalon
Actually, I think the, nevermind. I think the price is per four ounces. Maybe it's I'm unclear available in four ounce increments. I don't know.

Maybe that means they, they charge that for every four ounces. That's an expensive state.

Barry Conrad
Okay, I'm going to, I'm going to scrap that one rewind. I'm going to go, I'm going to do a, the wag you SRF rib cap.

Melanie Avalon
Mm-hmm. Do you like do you like fattier? Have you have wagyu?

Barry Conrad
Is this why do you think that's more fatty?

Melanie Avalon
Yeah, it's it's like really fatty. It's that that it's it's like actually it's not as much saturated fat, but the wagyu Stakes are really they're like raised to be really really fatty

Barry Conrad
Your reaction is really fun. It's just like hmm. You like

Melanie Avalon
Well, I just don't I don't I always feel like you don't like fatty as much but I feel like

Barry Conrad
Which one of those do you think would be like the biggest and the smallest.

Melanie Avalon
probably the porterhouse, which would be a strip and a filet. Yeah, the porterhouse, because you would get a strip and a filet.

Barry Conrad
I'll do that one.

Melanie Avalon
perfect. And then I think I, I love a good center cut filet mignon, not cooked, preferably blue. And I'm trying to think if I would, because I'm probably still going to be hungry. I think I would get, yeah, I think I would get the, the center cut filet mignon and then for dessert, I know what I'm going to get to fill me up.

I might add, I might add something to it too. You can add grilled prawns maybe. That's Australian language. Yeah, it actually really is. Yeah, we don't, because that's shrimp, right? Or is it different?

Barry Conrad
Exactly. I would get a bourbon steak sauce over my porterhouse and I don't think I'm going to get any sides because we're getting those fries and by the time we get this main situation, probably would have gone through two or three servings of fries.

Melanie Avalon
that's highly likely. Yeah. How would you get it cooked?

Barry Conrad
Medium rare, not too medium on the rare side.

Melanie Avalon
Sounds good. Okay, should we look at the dessert menu?

Barry Conrad
Let's fast forward. There's a lot. There's other things there, but I feel like I'm happy with my choice.

Melanie Avalon
Oh yeah, the rest is, it's like fish and chicken and then sides, right?

Barry Conrad
Let's do this dessert menu, what do they have?

Melanie Avalon
For dessert, I'm going to have whatever from the appetizer, like the medley that I like the most. So if it was like the shrimp cocktail, if it was the lobster, I'm going to get like another round of that. That's my dessert.

And that comes from the cold part, not the warm kitchen. So they won't hate me as much.

Barry Conrad
I'm going to do there's a couple things that I'm going to do the bourbon steak chocolate bar, which is peanut butter crunch, chewy chocolate brownie, as well as the brûlée Basque cheesecake, which is roasted Harry strawberries, Grand Marnier turbinado crunch that looks pretty good.

Melanie Avalon
Interesting that they have a chocolate bar. I don't really normally see that before, you know. Are you gonna get an after-dinner beverage?

Barry Conrad
I sure am. Let's go to, what do we got here? There's dessert wine. Oh, there's a wine list. Let me get a, let's first go to the cocktails. So beverages, hmm. I'm gonna go bourbon steak, old-fashioned. You know, I like to try the specialties of the establishment, so I'll try one of those.

And then I'll also get a, like a good red wine, like a good, cause they're eating a bit of meat there. So maybe some Pinot Noir, the 2022 Bell, glass, Clark telephone, Santa Maria, California, Pinot Noir. What about you, Mel?

Melanie Avalon
I would have to look through. So they have a massive by the bottle list. So this would be a situation where I'm doing my whole research and because I am sure on this massive list that they have something I like, which would be, you know, European, probably French, lower alcohol, lower sugar, maybe a cab prong, maybe a pinot. They do actually have a wine by the glass that says it's organic. So that's cool.

It actually says on the menu, they don't normally, you know, say that I feel confident I could find something awesome. And then this would be in the most magical, one of my favorite places in the world, the in the Swan and Dolphin Hotel.

Barry Conrad
So good. How long do you reckon we, Mel, when we finally do eat together, how long do you think we need our reservation to be?

Melanie Avalon
Yeah, well, the thing is, here's the thing. I like eating later. I don't know. We're going to be there a while. I think I feel like we'll be there like four hours.

Barry Conrad
I reckon so. We'll just be eating, drinking, eating, drinking.

Melanie Avalon
at least three will be that table like that table, that annoying table that won't leave.

Barry Conrad
Table twenty two still going can you just please take over I have to go.

Melanie Avalon
I'll be like talking to servers like you guys you guys can close out like we can a different server the closer can take Us now if you need I Won't take it personally. I know the lingo.

I know the lingo You can do your side work and like do we can go ahead and pay so you can do your paperwork and the closer can take us Man awesome awesome. Well, this was super fun. Yay, and it's so fun because it's like a celebratory night where you're gonna eat all the things

Barry Conrad
I know I'm so this is getting me ready for it too I'm getting inspired by all these.

Melanie Avalon
Oh my goodness, I love it. Awesome, awesome.

Well listeners, friends, thank you so much for all your questions and all the things. These show notes for today's episode will be at ifpodcast.com slash episode 443. Those show notes will have a full transcript as well as links to everything that we talked about. So definitely check that out. And then you can submit your own questions. You can email questions at ifpodcast.com or you can go to ifpodcast.com and submit questions there. And you can follow us on Instagram, we are ifpodcast, I am Melanie Avalon. Barry is Barry underscore Conrad. And I think that's all the things. Anything from you, Barry, before we go?

Barry Conrad
That's all the things we just want to say that we really appreciate each and every one of you listening and taking time out of your day to spend with us. So thank you so much and we'll catch you next time.

Melanie Avalon
I know, right? We really appreciate you guys telling you now. Awesome. Well, I will talk to you next week. Bye.

Thank you so much for listening to the Intermittent Fasting podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team editing by podcast doctors, show notes and artwork by Brianna Joyner and original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week. 


Oct 06

#442 – Special Guest Nayan Patel, The Glutathione Revolution, Shocking Antioxidant Facts, Boosting GSH, The Importance Of Protein Substrates, Vitamin C Pro-Oxidation, Skin Support, Alcohol Detox Support, Copper Peptide Serums, ATP, Enzymes, NAD+, & Amino Acids, Effective Clean Skincare, And More!

Intermittent Fasting

Welcome to Special Guest Episode 442 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, biohacker, founder of AvalonX, and author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine, and Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC


Dr. Nayan Patel is a sought after pharmacist, wellness expert, and thought leader in his industry. He has been working with physicians since 1999 to custom develop medication for their clients and design a patient specific drug and nutrition regimen. He has been the pharmacist of choice to celebrities, CEO’s and physicians themselves.

He recently published his first comprehensive book, “The Glutathione Revolution: Fight Disease, Slow Aging & Increase Energy.” After more than a decade of clinical research on the master antioxidant, glutathione, Dr. Patel finally shares how powerful and essential glutathione is to the body’s detox system. He speaks about the various benefits it has with slowing the aging process down, and explains how you can increase your levels naturally. Dr. Patel is a firm believer in providing the body with tools it needs to defend itself and promote a healthy lifestyle that fits the pace of the modern world.

Nayan Patel, Pharm.D is globally regarded as the foremost go-to expert on absorbable forms of glutathione, and holds the only patent on transdermal glutathione. In addition to many other topics such as cellular function and hormone replacement, Patel is a highly sought after global authority on the critical role in that glutathione, and all other antioxidants and endogenous molecules play in the body. Along with traveling the world educating practitioners on advanced biochemistry and anti-aging science, Dr. Patel also serves as adjunct faculty at the University Of Southern California School Of Pharmacy where he is also an alumnus.

He is currently a licensed compounding pharmacist that is still involved in designing and compounding drugs and nutrition therapies for his patients that includes athletes, CEO’s, highly stressed actors, physicians themselves and the community where he has practiced for 27 years. Besides being a pharmacist, CEO, and leader, he is a father to his three kids, husband to his supportive wife and a son to his dad who is the inspiration to help heal the world.


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Original theme composed by Leland Cox, and recomposed by Steve Saunders.


Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.


TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)



Melanie Avalon
Welcome to Episode 442 of the Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat, with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, founder of AvalonX, and author of What, When, Wine. Lose weight and feel great with paleo-style meals, intermittent fasting, and wine. And I'm joined by my co-hosts, Barry Conrad, actor, singer-songwriter, and creator and host of Banter with B.C. For more on us, check out MelanieAvalon.com and BarryConradOfficial.com. You can submit questions for the show by emailing questions at iapodcast.com or by going to iapodcast.com. We would love to hear from you. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time, and get ready for the Intermittent Fasting Podcast.

Hi, everybody, and welcome. This is episode number 442 of the Intermittent Fasting Podcast. I'm Melanie Avalon, and I am here today with such a special guest. Friends, I am so excited about this conversation. So this fabulous guest I have actually had on the Melanie Avalon Biohacking Podcast twice now, and I have met him and hung out with him multiple times at multiple conferences. He just happens to be one of my favorite humans in, I mean, this whole sphere. And that is Dr. Nayan Patel. I first met him when I read his book, and it is called The Glutathione Revolution, Fight Disease, Slow Aging, and Increase Energy. And friends, when it comes to our health and wellness, we talk a lot about antioxidants. And you might have heard, I mean, I feel like most people have heard of glutathione, you know, and you might be doing things like getting IVs even, or taking, you know, supplement forms, or, you know, trying to boost your glutathione levels. And there is a lot of confusion out there when it comes to what is the best way to actually support and boost glutathione in your body because it is our master antioxidant. And especially friends, when it comes to things like fasting and diet and fitness, antioxidants are so key to feeling well during everything and not only feeling well, but really optimizing your life. And I now honestly, so I read the book, I learned all about what glutathione actually is, how it functions in the body, how you actually can increase it. And I started using Dr. Patel's transdermal form of glutathione. I use it every single night of my life. And I have now for years, that is a true statement. And on top of that, I also use some of his skincare products, which are incredible for your skin. Prepare to have your mind blown because this is going to be just an epic conversation. So Dr. Patel, thank you so much for being here.

Dr. Nayan Patel
Well, thank you very much for having me here today. I appreciate the introduction.

And I'm glad that your audience is savvy and they're looking to improve their health. And I appreciate this. I can't believe this is a 4 and 20 second episode and your audience is still here. So that means you have some great information. And I'm glad to be here as a messenger for the Health and Wellness Journey.

Melanie Avalon
I think now we've seen each other maybe at maybe three conferences and it's always like super hectic and I feel like we always like squeeze it in like one of us is leaving but it happens every time I do see you and also fight on because you I forget you you taught at USC or went to USC.

Dr. Nayan Patel
So I didn't do my graduate school at USC and I'm still have edging faculty over there as well.

Melanie Avalon
Yes, awesome, awesome, awesome. Okay, so I have so many questions for you. It's exciting because I pulled out all my old notes from when you've come on before and I have so many notes here.

So glutathione, a little bit about your personal story. When did you realize that you were going to become the glutathione guy and how do you feel about that?

Dr. Nayan Patel
Boy, you know when you grow up as a kid, no one wants to be a glue with iron guy They want they would be an astronaut. They want to be they want to conquer the world They want to be a doctor They would have been something something very very nice and cool, but not a glue with iron guy for sure And that was not my dream either But you know what I I learned something differently if you keep your arms open and in your heart open The universe will guide you to what's necessary and what's what what people want And I thought I was guided towards working on this molecule by I don't know who but anyways I was guided to to work on to bring this to the To the world and hopefully they can experience the power of what glue time does inside a body Naturally, and so I thought this journey back in the late 90s early 2000 When I was hired to work on actually like liposomal vitamin C And they thought the vitamin C is the next the best antioxidant that ever existed so can we make it better and so I started doing some research and I found out wait a second Glutathone is by far the most powerful antioxidant ever body produces.

Why are we talking about glutathione and The doctor that hired me told me oh, no, that's too hard to work with so let's just stick to vitamin C So I did his project but on the side. I said wait a second Why is this so hard and so that was my first introduction to bring something in the marketplace back in the late 90s early 2000 and The rest as I say is history because all you can do is once your heart gets into something to work on We discovered a stable form of glutathione in seven years.

So by 2007, we already have a stable molecule It was able to get through your skin inside your cell the cell membrane took me another 13 or 14 more years to do research to figure out how much to give you how often to Give you how long can I give it to you for? Am I gonna get results results repeatedly if you take it for five ten years in a row? Is it gonna get better and better every single time? And so I had a lot of questions and not enough answers in the world So I said I'll do my own research and eventually by 2021 We were able to release the product of the to the public in the mid in the middle of the pandemic So that's my story

Melanie Avalon
Wow. Okay.

So many things here. So interesting about, you know, them saying glutathione was too difficult to study. And then, you know, you worked for years and years to get this form that we can get into our body. Something I learned in your book, actually, is so glutathione, is it the second most abundant molecule in our body?

Dr. Nayan Patel
That's right, next to water. That's crazy. It is, and the thing is, we don't even make water, we drink water.

Melanie Avalon
Yeah. Wow. Okay. So I mentioned in the introduction, like this word, antioxidants, and you've mentioned vitamin C now, glutathione, for listeners, because I think people hear antioxidants and they think, oh, like good things that, you know, help us.

So how do antioxidants actually function in the body? And in particular, what is the difference between, because you just mentioned we don't, we drink water, we don't, you know, create it. What is the difference between antioxidants that our bodies naturally create versus taking them in through food and supplements and things like that.

Dr. Nayan Patel
Absolutely. So that's a great question. I think there's like three or four questions in there, and I'll try to get everything into like one example. So hopefully everybody gets the whole picture of it.

But when you look at antioxidant, there's lots of fruits and vegetables and vitamins in the marketplace today that claims to be an antioxidant. At the end of the day, there are only three ways to reduce oxidation in our body. Now, the reason we need antioxidants is because our body is exposed to oxidation every single second. Because you breathe oxygen, when the oxygen gets inside your body, if it's not getting used up, the excess oxygen is actually producing oxidation to your body. When the oxidation inside your body increases to a point where your body can neutralize those oxidation, it becomes oxidative stress. And that oxidative stress leads to all kinds of diseases.

But that's a stick on the oxidation part. And so what's the big deal about oxidation? I'll give you a simple scenario. If you just take a piece of nail, an iron nail that you get it from your local hardware store, if you put some water droplets on there and put it outside in the sun, within a few days, it will get rusted, right? And once it gets rusted, that's it. And if you don't do anything about it, then eventually the whole thing will just become powder and it's gone, right? And so the whole process is called oxidation. So the oxidation is happening inside our body all the time. Either we breathe oxygen or the oxidative components that are introduced inside our body because of chemical reactions that happens every single second in our body. All those leads to oxidation and will lead to oxidative stress eventually.

So antioxidants is what we need to neutralize those parts. And that's one of the reasons why we body produces so much glutathione because it's the master antioxidant our body produces. And by the way, there's only three or four things our body produces that are considered as an antioxidant. One is glutathione. I'll put them in bucket number one. The bucket number two is the body produces three enzymes, which is catalase is one of them. Superoxide dismutase is SOD. By in short, I believe there's a major skincare company that uses SOD as their flagship product to deliver as an antioxidant. And the third product is glutathione peroxidase enzyme is GPX for short. So these three enzymes are basically are components that helps reduce oxidative stress. And I put them in bucket number two. And the bucket number three is all the antioxidants that you take from outside sources, like vitamin C. Our body does not produce vitamin C. We take it from the fruits and vegetables that we eat. Vitamin E, CoQ10, the juices that you drink and the pills you take. I mean, there's so much things that's out of the bucket number three.

And I'm going to tell you something really, really profound right now. That is bucket number one, which is glutathione. Glutathione by itself is more powerful than bucket number two and three combined.

Dr. Nayan Patel
And so I just want to make people understand that part that if you only have one chance, one chance to get yourself healthier, are you going to put yourself in antioxidants from outside sources like any carrot juice and orange juice and things like that? Or are you going to put all your faith into one molecule which is glutathione?

Which me, personally, of course, is glutathione because it's by far the most strongest one, the most powerful one, the most abundant molecule producing your body that will deal with all these problems for us.

Melanie Avalon
Oh my goodness, I see friends. This is why I love this conversation because we are actually getting the information on antioxidants. I have so many questions.

I have a very random, just really quick question to ask because I was contemplating this actually last week. When you go and you look at the steaks at the store and they're red and then some are turning brown or you have them, you bring them home and then they turn brown, my understanding is that the steak oxidized. Is that correct?

Is that why it turned brown?

Dr. Nayan Patel
That's exactly right.

Melanie Avalon
So is that, this was the question that I have. If you still eat some of the steak that had turned brown, does that have a problematic ingredient in it for your health since it's oxidized?

Dr. Nayan Patel
So there are a few components in there. You're not eating steak for antioxidants. You're eating steak for amino acids. There's a bunch of protein in there. There's a monosylic topping down into various amino acids. And that's what you're eating the steak for.

The top layer that is getting oxidized, it's the tissue that's getting oxidized. Is it bad for you to eat oxidized food? Kind of. But the thing is, the majority of the food that you're eating on the steak is inside, not the top layer of it. So the grand scheme of the whole thing is not a bad thing. Keep in mind, whenever you cook any meats, any meats, the top layer is going to get oxidized anyways, always. Because it is going to oxidize. So the top layer of all the meats is what we call them is advanced glycation end products, A-G-Es, or in short form, H. And guess what the advanced glycation end products do to you? They make you age faster. So A-G-Es are not good for you. In moderation, their body can deal with it. As long as you have enough glue or thion, they will neutralize those A-G products out of your system and you go back to normal. But eating a lot of those foods is definitely a problem. The number one food has the highest amount of A-G-Es in there, is guess what?

Melanie Avalon
while protein reacted with sugar, right? So, I mean, I don't know. I hope it's not cooked meat.

Dr. Nayan Patel
because it is the very high temperature and very short amount of time. They try to zap every single thing with a very high temperature and that that pizza has the highest amount of AGEs or advanced glycation end products in them.

Now of course if you have home-good pizzas that you do a low temperatures and different story but I'm talking about store-bought pizzas that's the same thing. So going back to your steak if it's out at the top part is brown I'll rather not have that but you know what the grand scheme is not as bad as you think it is.

Melanie Avalon
Thank you so much. This question has been haunting me. I said last week, that's when I was really pondering it. But honestly, for years, I think it, I think it every time. So thank you.

Little thing about the AGEs. It's just funny to me because I always assumed that it just was a coincidence that AGE, like that advanced glycation in product, that that was the acronym, but they actually purposely, it was purposeful. I think I want to, I've heard something about this. Like they actually called it that in part because it made that acronym. So the science community has their, their, their humor, I guess.

Question about the timeline because you just mentioned how there's these three different groups of antioxidants and, you know, glutathione way surpasses its potential of the second two groups. And that, that third group is the one I think most people think of with antioxidants because they're thinking of fruits and, you know, different foods that have vitamin C and vitamin E and all these antioxidants that we often think of a reason this may be a good thing. And it's going to, that will be answered in part with my question is what is the, the timeline of all of these different antioxidants and the body, the curiousness I have here, especially with the intermittent fasting podcast audience is, you know, when people are doing their fasting, we do a lot of water only fasting here. So it's not like people are going to be drinking fruit juices for antioxidants during their fast. So how does it play out when people are fasting and detoxing and needing these antioxidants and using up antioxidants, where are they coming from?

What's the timeline? So like how, how do we keep glutathione like going during our fast? If we ate antioxidants the night before, are they still around during the fast? How does that all work?

Dr. Nayan Patel
So to produce glutathione, we need three amino acids, glycine, glutamine, and cysteine. So cysteine is one of those amino acids that is not abundantly following most diet. So if you just put in a furious search engine, cysteine-rich foods. And so as long enough cysteine coming from your diet on a daily basis, you could not eat for a whole day, and your body has enough cysteine to keep on producing this glutathione for the rest of the day, not a problem whatsoever.

So we just have to make sure there's enough basic components that it needs to produce its own glutathione as it demands increases. Now when the intermittent fasting people has lived a different story because what they're triggering is autophagy or senescent cells. What's triggering is that, hey, it's trying to get rid of all these dead cells, zombie cells that could be high in inflammation and low in any kind of energy source. So you want to try to get rid of it. And so that's what the IF community was all begun with, is to increase that component. But having to produce glutathione, I mean, you can fast for a couple of days and your body still has the ability to produce its own glutathione on a regular basis as long as there's enough cysteine to die because cysteine stays in the body for a little bit longer time. I can tell you another thing because this was interesting to me when I first started doing my research in glutathione is because they were injecting this glutathione into the blood and initially they got the results. Then there was no results for a while, like for six hours or so, and they said the results again. And it says, why there was a gap? What they found out was when you inject glutathione, the body sees glutathione as a protein, that's like three amino acid chain protein. What does the body do with the protein? It chops it down into various amino acids. It does not absorb any proteins whatsoever or a peptide, whatever. So the body was chopping it down and the chopped up item was, it was chopping it down between five to 20 minutes, something like that, very short on time, it was all gone. The chopped up material was actually cysteine. So cysteine was reabsorbed into the bloodstream. And so they saw three or six hours later, there was a sudden increase of cysteine in the blood and that cysteine was actually being used to make your own glutathione naturally. So what I'm saying is that for your patients, for your community, that is fasting, as long as the diet has some sort of cysteine in there, the body will store it and use it to produce its own glutathione as it needs.

Melanie Avalon
Wow. And what I think is such a paradigm shift here for people is again, I think when people think antioxidants, the general bucket, they mostly think fruits and vegetables, like that's what they think they need to get.

And now we're talking about how glutathione is our master source of antioxidants and it's created from protein, not these fruits and vegetables.

Dr. Nayan Patel
That's right. And the thing is, okay, so we just talked about antioxidant melanin, but I think the audience needs to know that if the body produces so much glutathione, is their job is only to be an antioxidant? That's it? It's just one job, right? If we produce so much of this molecule inside the body, and by the way, the body has a system to recycle, because guess what? If the glutathione neutralizes a free radical, it itself gets oxidized. An oxidized molecule basically becomes trash, right? There's no use for it.

But the body has a system built into it where it recycles this glutathione. It accepts energy from sun and other molecules that you eat, and it becomes reduced again. So again, it becomes an antioxidant. Just to give you an example, I'm going to give you an example. You take vitamin C. Vitamin C is the number one antioxidant sold in the world today, and I'm about to tell you something that is absolutely profound. Vitamin C as a chemical is not an antioxidant. It is actually a pro-oxidant, yes, it's actually a pro-oxidant. But the thing is, at low concentration, vitamin C actually provides the energy to access form of glutathione and revives them back to normal to make it a reduced form of glutathione that can be used as an antioxidant again.

Melanie Avalon
That's mind-blowing. So you're saying the benefits, the quote, antioxidant benefits from vitamin C are actually not that. It's actually helping recycle glutathione.

Dr. Nayan Patel
That's exactly right, yeah. And the medical community knows about this thing, but they said, well, that's true, but you know what? It still works. Just because something works does not mean it is going to work every single time.

As a pharmacist, my mind is always working towards, if it works in one person, it should work on everybody. If you have a problem, if it works in one person, it should work on everybody, if it's the same problem. And if it's not, then it's not the issues with the problem, it's the issues with the product that you're using, why it's not working. And so that was my quest originally to find out. I said, if gluten is so good for you, it should work for everybody. But even the IVs did not work for everybody. Even the other technology products that are out there does not work for everybody. And my question is, why not? Why is not working for you? If your body needs gluten, it should work. And the answer is the body has to make its own glutathione from scratch. Doesn't matter what you do. And if the body doesn't have the ability to produce glutathione, you can take all the building blocks in the world and the body is not able to make glutathione. And if that happens to any one of you, you'll go down really fast. I mean, two to three years tops, you have all kinds of diseases and you have no idea what happened to you. And you get cancer, you get all kinds of things that happen to you. And all of a sudden, oh my God, you're going downhill from here. It happens that fast.

I want to make sure people understand that antioxidants that you take for fruits and vegetables are all actually reviving glutathione as an antioxidant for itself.

Melanie Avalon
Wow. Okay. So some questions from there. So you mentioned this recycling power of glutathione, which is awesome.

I also read in your book that can it not be recycled when it's used for detox? Like there was a certain type where it's not recycled.

Dr. Nayan Patel
So that's the second part, right, Melanie? We talked about one job of growth is an antioxidant, and that's a big job. That's a huge job. There's a bigger job than that is to help your body, help your liver detoxify every chemicals and whatever you consume out of your body. And if you do not get the garbage out of your body, within a few days, months, or years, your body will be filled with all those toxic chemicals, and that's usually going to be the end of us as well.

So the two parts that glutathione does for us is as an antioxidant, it recycles itself as a detoxifying agent to help conjugate and get rid of the toxic chemicals outside the body. But when it does that, it uses the whole glutathione molecule once and for all. And so for detoxification purposes, your body has to keep on producing more and more glutathione all the time. Only for antioxidant purposes, the body will recycle the glutathione itself.

Melanie Avalon
Wow. So that in particular, because when people do fasting, which is very, you know, very beneficial for the body and supports health, and you were mentioning autophagy and all these things, it also, you know, upregulates the detoxification process.

So I would imagine supporting your glutathione production while you're fasting would be really, really important. Would that be?

Dr. Nayan Patel
Oh my gosh, this is one thing that we have time and time over. People that do IF intermittent fasting or just fasting is in general, their detoxification activity is skyrocketed when you add growth to the whole regimen.

It is by far the single most important thing that will make a profound impact on your health and wellness.

Melanie Avalon
Wow. Okay.

Just to clarify, because I realize people might still be wondering about that, the vitamin C being a pro-oxidant thing. And you were mentioning some people, and you just mentioned now with glutathione how people take IVs and things like that, and it may or may not work for people. So with these different exogenous forms of substances, it sounds like with the vitamin C stuff, even though it's a pro-oxidant, do we need to be concerned about that, or does it all work out in the end? And then with the exogenous glutathione, and we'll talk about the form that you've come up with, but that form aside, people taking IVs and pushes and oral supplements, is that just doing nothing? Is it just sitting in the bloodstream? What is it doing?

Dr. Nayan Patel
No, so the vitamin C at low concentrations is actually providing the energy to recycle the glutathione. So it's a great product to have it, but in moderation. You don't want to over-consume vitamin C ever.

So if you take like 500 milligrams or 1,000 milligrams per day, it's plenty. It is plenty to recycle your glutathione all the time. Now, of course, if your oxidative stress is pretty high, then you may need a little bit more. But I would say that in that case, just make sure that you have enough glutathione in your body in the first place. So vitamin C will help recycle some of the glutathione. You take more glutathione to increase the concentration of those things. All the other antioxidants, so-called antioxidants in the food sources are just a helper. They're helping inch away the increase of glutathione inside your body. So I would say not to stop it, but do not over-consume any of these products, including glutathione itself, or consume that either. Now, I'll share the story about that one too, but everything in moderation is going to be good for us. Excess, the body does not have anywhere to store it and use up any excess products. So don't give anything excess to the body.

Melanie Avalon
Yeah, definitely. And then for the glutathione, the exogenous, and when I say exogenous, I mean forms that you're taking in that you're not creating inside.

Are they doing anything? Are they just sitting in the bloodstream? What happens with that preformed glutathione?

Dr. Nayan Patel
So the preformed glutathione is actually in every single cell in your body. So it doesn't matter if it's blood or tissues or any cell, any cell that produces that smartochondria is going to have glutathione in that cell. So you need the glutathione in each and every cell in your body. So it doesn't sit there forever because the glutathione is a very short life also.

It stays in the body for maybe a day or at the most for two, but I don't think it goes anything beyond those two days. So the body has to constantly produce more and more products all the time. So if you fast for seven or 10 days in a row, there might be some issues. But if you're just fasting for half a day or a day at the most, it's not a big deal at all. In fact, it's helping detoxify your body as well. I'm not sure if that's the question we're asking or not.

Melanie Avalon
Yeah, or so when people do like a glutathione IV, so that that glutathione, what happens with that glutathione?

Dr. Nayan Patel
So that gluten gets broken down into amino acids, cysteine gets reabsorbed, cysteine is later used to produce your own endogenous glutathione inside your body.

Melanie Avalon
Oh, we break it down and reuse it.

Dr. Nayan Patel
And that cysteine will stay in your body for maybe a day or two. So even though you take an IV, the results are not there immediately. Well, the results are there immediately before about five or 10 minutes, and then the results are not there for another six hours. And then once the cysteine kicks in, the body produces more glutathione. Now you have some more results coming in. So you may have results for another day or two at the most.

But the thing is, keep in mind, I don't care what form you take the IVs or the liposomes or the capsules, and the body breaks down and takes the amino acids and produces own glutathione. You are at the mercy of the body's ability to produce glutathione. Now don't get me wrong. You can produce glutathione until the last day. You can make new cells until the last day. Imagine you get a cut when you're 15, and imagine you're getting the same exact cut when you're 60, which is going to heal faster.

Melanie Avalon
Yeah, 16.

Dr. Nayan Patel
VF15 and 16, it's going to heal much, much faster than you are at 60, 65. You know why? Because to heal, you need to have all the immune markers, all the nutrients that it needs to heal the body correctly and efficiently. So even though your body can produce glutathione until the last breath, it produces less and less and less as we age. Because I only told you in these three components, glycine, glutamine, cysteine, there's three amino acids. It also needs two enzymes. It needs two molecules of ATP, which is energy. And as you can know, people as they start aging, the energy levels is drilling down anyways, right?

So if there's no ATP energy, but if you have all the enzymes and all the amino acids, your body still cannot produce enough glutathione. And the last thing for electron transfer, you also need NAD. What if your NAD levels are low as you age, which happens all the time? And so even though you may have all the ingredients, but if you do not have the energy source to make your glutathione, your body will not be able to make enough of it. And so if you tell a 50 or 60-year-old person to take glutathione supplementation and they say, well, I get some results, but not like fantastic results, or sometimes they don't even know. They think this is the best that can happen to you. And I said, no, it's not the best that can happen to you. The best is if I get you enough glutathione inside your cells that your body is used to having when you are 10 years old, 15 years old, if I get those levels back to you, that's what your body needs. And eventually, that's what your body is going to be using to heal itself from inside out.

Melanie Avalon
Okay. So that, yeah, that was going to be one of my questions earlier and you perfectly answered it, which was, I was wondering the role of just taking in the substrates that you need to create glutathione versus actually creating it, like what goes into that.

And it sounds like, you know, like you said, there's all these other things involved in AD and enzymes and the whole process. So, you know, it really requires holistic support to, you know, create this glutathione naturally when it gets harder as we age.

Dr. Nayan Patel
Let me ask you the next question. We want the body to make natural it all the glitter time. We want them to do all that work for us, right?

It's not like we want to take away that job from the body. But at the same time, as we age, if your body cannot produce enough, and if there is a way to give a little bit so that it reduces the workload for your body, that to me is still a good option than to just completely rely on the bodies that we do all the work for us.

Melanie Avalon
Yeah, no, that completely makes sense. And now I understand better what you're saying about the pulse effect when people were taking, or I don't know what they were using in the original studies, but if a person takes an IV, they get this initial boost because it's there, but then they break it down so then you don't see it, and then it rebuilds it up again, which again, if you're, you know, aging and have other taxors and, you know, aren't efficient at producing glutathione, I guess you could take, you know, all this, all these glutathione IVs in the world, and it could be difficult for you to actually reconstitute it into the glutathione that you need.

What did you discover with the form of glutathione that you sell and that you created that I mentioned that I now take every night? So what is happening with that glutathione?

Dr. Nayan Patel
I'm going to ask you another question afterwards too, Melanie, but I'll answer your question first. So when I first created the topical version of this, again, my goal is not to create topical version, it's just that the best scientists in the world are the one that observes things and let it happen the way it comes to you, not trying to change it. And so I was not about to change the form, I was just about to change, I was just about to learn how it works. And it happened to be the topical form was the best way to get the gluten inside your body, inside your cell membrane, inside your cells itself. And so when we discovered that, what we found out was that every single human being, regardless on what genetic makeup they have, were able to absorb the gluten inside your body. And I'll tell you another about the genetic makeup. There's a very small subset of people that we do gene testings today. Now for the last 15 years, we've been able to do gene testing. So we can find out gene mapping studies for people that have gene SNPs that they cannot do certain things in their life. There's few gene SNPs, which are GSTM, GSTP, GGT, these are all different genes required to produce glutathione. And if you're a mutation and your body cannot produce those enzyme that produces glutathione, no products in the world is going to save you. And so that to me was a major, major blow.

Now if you cannot produce glutathione at all, it's an easy one you'll find out very, very soon because you're going to go down really fast. What if people have other gene mutations like MTHFR, the most common gene mutation is MTHFR or COMT, where your body can produce plenty of glutathione, but the workload has increased to double, right? Because now the methylation path is shut down, somebody needs to detoxify your body, so needs for detoxification has gone up skyrocket. Since there's no methyl groups to do that work, the work is now falls on the glutathione to do the additional work. But the body says, oh, I'm already producing maximum amount of glutathione that you need. I cannot produce any more. Now what happens? And so what I discovered is those people had a profound impact on their life immediately after they had the type of glutathione because for the very first time, they had something in the cells ready to use up and help the body detoxify them immediately. And so to me, that was like an aha moment, I said, okay, now I have something to give to everybody. What if the people have, if they're young people and they're producing a glutathione? Well, they don't need my product at that time because the body has enough of it. And it would be in my best interest not to sell them a product because I said, hey, you know what? Your body can make it enough. Just stop drinking alcohol, stop doing crazy things, don't eat junk food, just drink water, and you'll be fine. You'll be literally, you'll be fine. If you want to cheat once in a while, it's not the end of the world, but I'll try not to do that, but it's not end of the world. But if you're an older person, when I say older, I don't mean that old by the way you are.

Dr. Nayan Patel
Anybody over the age of 30 and above, they're not old, but the body is now not able to produce enough glutathione. They will have an impact immediately after using the product because it is actually getting inside your cells, right?

And when it first happened to me in 2007, I got so scared because some of the really sick people had a major detox reaction. Like when that happened, I got scared because, oh, you know what? As a pharmacist, as a medical professional, our first goal is not to do any harm. And so if I had no answers for it, I said, you know what, let me find out. So we stopped the production, we stopped selling the products. We made a prescription item only. We started talking to the doctors. And so for 14 years, all we did was sold via prescriptions and told the doctors to report back to see what kind of problems you're having.

And so we found out, actually, how much to give you, how often to give you, how long can I give it to you for? And the amount we give you, like for IVs, I can give you one grams, two grams, five grams, 10 grams of IV push, and nothing will happen to you. For the topical version, I can only give you 100 milligrams at the most 200 milligrams. And that's it.

Melanie Avalon
Wow. Okay. I'm just curious because I do, like I said, I take this every night. How many sprays is that the equivalent of?

Dr. Nayan Patel
Also, four sprays is the typical dose. Four sprays is about 100 milligrams.

This is on the regular version. The plus version, I didn't even release the plus version until 2022 for the very first time. And that's because most of my clients, they get too much money and they go, if less is good, the more is better. I says, no, it's not. And they don't listen to me. So they just said, can you give me more blood? I hate to keep on applying more and more sprays. So that's why we lose the stronger version. But since we're losing the stronger version of the Glothine, we had some more studies done on that as well. And they have some merit to it as well. But overall, I still think that the regular version product is going to be sufficient for almost 90% of the people. No problem.

Melanie Avalon
Awesome, okay, and so to clarify, so what you're saying with this form is that it bypasses what we were talking about earlier about needing to break down the glutathione and recreate into glutathione. This actually gets the glutathione directly into the cells to be used.

Dr. Nayan Patel
That's right. It gets in skin cells and then from there it gets transferred to the rest of the body.

Melanie Avalon
to that point. And this is something, and I know you've explained this to me before, I just can't wrap my head around this, actually with anything really.

It's hard for me to wrap my head around how whatever the supplement may be, but we'll talk about, you know, oral glutathione in this case, how putting it in one area can have a systemic effect. How does that work?

Dr. Nayan Patel
So yeah, the thing is, if you look at the medical literature, there's multiple ways the signals are transferred from one part of the body to the other part of the body. For example, if you step your foot on a nail, how fast will you take it off? It's really fast, right? But the brain got the message that, oh my God, Melanie just stepped the foot on the nail, and it hurts.

So there's a signaling from the, those are the neurons that send the signals straight to the brain. I said, hey, what do I do? I said, what do you do? Take the foot off, right? And you're done. The same signaling pathway that we have for the neurons, we also have to transport nutrients. And so every cells are closely bound to each other. Like a cell is not by itself, right? So a cell right next to it, there's another cell touching to each other. And this cell is all over the body. That's why if you put something in your tongue, under your tongue, like a sublingual drop, right? Let's say you could, let's say you took a B12 drop sublingually under your tongue. Within seconds, your brain's going to feel it, right? Or if you drink a caffeine, right? If you take a caffeine pill inside your stomach, instantaneously, within minutes, it's going to hit you, it's going to hit in your brain. How do you get transferred to all the systems, right? It's not the blood's going, the blood's not transferring nutrients. It's the cell-to-cell transfers, right? And so there's something called lipid rafts on each cell. On the lipid rafts, there's some ACE receptors. The receptor is basically accepts a nutrient from outside sources. And then once again, inside your cell, all the excess, it keeps on transferring to the rest of the body.

Melanie Avalon
Pretty magical.

Dr. Nayan Patel
The body is absolutely magical, as I said, our job is not to recreate the body, it's just understand and work with it.

Melanie Avalon
And so does it still, in addition to having this systemic effect, does it also, could you concentrate it on a certain area if needed for something on that area for skin or an injury?

Dr. Nayan Patel
This is so most of people they apply let's say for the joint issues that join directly and the pain goes over the joint right there is a local effect that's the same. Only the excess gets transported to the rest of the body so if you have let's see if you have skin issues and put in your face the facing of the first.

I refuse all use of all the price on the face that you need the rest extra yes transfer out of the rest of the body.

Melanie Avalon
Okay. Yeah. Because I've been wondering actually with using the skin products, I'm like, I wonder if any excess glutathione is, if I'm getting any excess, or is it just staying local in my skin?

Dr. Nayan Patel
No, you are getting access because the skin product that I have made up is actually a little bit stronger than the regular product. And the reason I make it a little bit stronger is because most of the people that apply the skin care product is applying a very small area, a localized area only.

And so I had to make sure that I get an impact immediately. So I made it a little bit stronger skin care product so they get the localized effect faster.

Melanie Avalon
Awesome. You said you had a question for me?

Dr. Nayan Patel
question for you. You said you've been using this product for a while. Can you share me a routine and what makes you use this product every single day?

Melanie Avalon
Sure. Yes. So, and I'll be curious how my routine compares to, you know, what I quote should be doing. I use it though, I use the, the Oro spray and I use it every single night. I use it at night because that's when I'm having my glass of wine and winding down at the end of the day.

And I spray it on my chest actually. I did, I knew it's funny, um, Dr. Patel, because I can remember when we first talked about this, when you first came on the show and I had just started using it, I think I'm pretty sure. Um, and it probably would have been 20 around 2022. Cause I, I think you had out, I think you would just release the extra strength version. In any case, I remember I was communicating to you that it smells soul furry. And, and I was like having to get used to that because it definitely, it definitely has a distinct smell to it. And when I first started using it, I was like, oh, this is an intense smell. I don't even really notice it now. Like I'm so used to it. It really, it doesn't bother me at all is the point. So listeners, my, my point is if the soul fur smell feels like a little bit much to you, just keep going. You won't even, you won't even realize that in the end. And the nice thing is it doesn't, it doesn't linger. It goes away pretty fast. I do a couple of sprays every night and I do it with my wine. And then if I'm, if it's a night when I'm going out and I'm having more than I am, I have it when I, when I'm going to bed and then what's the half-life on it? I might be overdoing this. If I wake up in the middle of the night, I will like spray some more on me.

Dr. Nayan Patel
It's about four to six hours, yeah.

Melanie Avalon
Okay, that's perfect. So yeah, cuz I'll usually like wake up, you know, like four hours later, and I'll, I'll spray some more. And I find it to be a wonderful tool in my toolkit for those nights out. I love it so much.

But I don't do it during the day. I wonder if I should be

Dr. Nayan Patel
No, thanks for sharing that part. The normal dose is about four sprays twice a day, and if you're going to have a glass of wine, then by the way, each glass of wine will wipe up your gluten levels to zero for the next four hours, and that's unfortunate.

Every drink of alcohol will do the part, so I'm glad that you applied the gluten right away, so that way your wine never fills the wrath of not having any gluten itself. And the reason you're waking at nighttime and applying it again, because your gluten level is not increasing fast enough, but it's an amazing tool to help you increase your deep sleep, especially after alcohol, so your HIV will not drop so low, and hopefully you'll have a restful sleep. The whole idea behind this thing is that it helps you metabolize the alcohol faster, so it does not linger on to give you the sleep disruption that it can normally cause with alcohol. But if you use it twice a day, twice a day is probably the most ideal way of using this product. And the reason is because I'm a creature of habit, right? I only use it once a day for four years, but I tell people to use it twice a day, because the thing is I never form a routine for myself. So about two years ago, I really sat down and wrote down my routine, my morning routine and evening routine, and I taped it in my room mirror, right? It's my morning routine. And then once I put the routine in the place, it took me about six weeks to do it twice a day, every day. And ever since that time, I do it twice a day, every day.

And over the years, over the last two years, I've done multiple tests to find out about my age and my metabolic markers and my organ health. And I can tell you right now, I got no problems, first of all. That's the best part is that my biological age is decreasing finally. I did another test, another one again right now. So I'll get a different number again for the next time I see you. But my overall health and wellness has just gone skyrocketed in the good direction. So all I'm saying is that, yes, it was hard for me to do it twice a day. Once I put the routine in place for the last two years, it has really transformed my whole body in the last two years, more than ever before.

Melanie Avalon
Which testing did you use for the biological age?

Dr. Nayan Patel
So, I'm using a generation lab at this time, so I'm measuring all the organ health, because you're only as good as the weakest organ, right? If one organ is telling me that you are aging 65 years of age, then I don't care if everything else is 20 years of age, my dead organ is 65, I'm 65 right now.

For example, heart. If my heart is old, if the heart gives out, does it matter if your liver is 20 years old? No.

Melanie Avalon
Yeah, there's so many out there. So that's why I was really curious.

And that's a good point about looking at the organ specific ones. I love that. I might have to, okay, might have to change my routine, start having mine in the day as well.

Dr. Nayan Patel
Well, twice a day is better. But I think the morning one, I usually do it like half an hour 45 minutes before shower. So that way I wake up, I put my glove on first, do my morning meditations, my stretching. An hour later, I usually go shower. By the time it's done. So it does not see the body for long anyway. So it's okay.

Melanie Avalon
And what about the role? So my favorite of the skincare products right now, cause you have other things coming, is I love the citrine serum so much.

So your high dose, well, is it high dose vitamin C and glutathione? What is in it?

Dr. Nayan Patel
high dose vitamin C. The glutathione is just there to support the vitamin C getting into the complex, but the real work is done by vitamin C itself. Now, as you know, a body doesn't produce vitamin C. It's a pro-oxidant, but it's a very, very low grade pro-oxidant. It's enough to stimulate your cells in your face to have cognitive production, to put defense around it. So it is stimulating your body to do the right things to having cognitive production. So you have normal wrinkles, normal fine lines, things like that. So yeah, the number of products, unfortunately, people like citrine more than the glutathione itself when it comes to the face, but I'm just telling you my thing is G serum is good because yes, the results are not instantaneous, but the thing is once you do get the results, which is sometime during the cup of second, third month, it's a very profound impact in your life as well.

So that's the way I look at it, but your skincare, it's a statin skincare, right? All products are different. If you want to do one product, you submit any serum first, and then you pair that with the moisturizer that goes with that serum, and then the third thing you put the second serum on, and then the fourth thing is put the moisturizing pair that go along with it. All four products have different ingredients inside. All four work synergistically. You can start anywhere, but if you want to start anywhere, start with the serums first and then pair them with pair them with with with its moisturizer.

Melanie Avalon
And I will say to this point, because my audience has heard me talk about the importance of effective and clean and safe skincare for years and years and years. Friends, I have had conversations with Dr. Patel. I trust you so much with your production of these products.

Like we've had offline conversations about just what goes into creating them and sourcing and the materials and I just trust you so much. And I am so grateful for what you're doing with creating these products, because there's a lot of problematic products out there that not only might not be effective to the point that you would think, but also could be problematic with their ingredients and toxins and endocrine disruptors and such. So thank you for creating these products. And I know they're hard for, I know I don't wanna like speak for you, but I know a lot of energy and time and money goes into making these products and they're not easy to make, I don't think.

Dr. Nayan Patel
Thanks for saying that part because that is something that is, if I want to take the product myself, I want to clean product for myself. I don't care about anybody else. For myself, I do care as much as myself. So I want to make sure that anything that I put inside my body is clean.

So like for example, ascorbic acid, vitamin C. Ascorbic acid, again, I don't advertise this anywhere else because it's not my job to do that part. My job is just to create clean products. Ascorbic acid, 100% ascorbic acid in the United States comes from corn, all of them, right? And it's the cheapest way to get your ascorbic acid. It's the cheapest that you can buy. But guess what? All corn in the USA is GMO. It's all modified. And so I said, I cannot, even though it's a very small amount, I don't want to have to put in myself any molecule that is GMO. So guess what? The ascorbic acid that we use is non-corn-based ascorbic acid. Is it cheap? No, it's not cheap. It's not made in the United States. It's made in Europe, right? But guess what? I had to make sure that I get clean products for myself.

Now, this could be a great marketing tool if I want really to market it. But then to do that, I had to put every other product down. And that's not my goal either. My goal is to work with everybody. And I'll just do the right thing for myself. And hey, if the consumer finds out, that's good for them. But if not, I know in the back of my mind that I'm creating good products. That's how it matters.

Melanie Avalon
Yeah, I just, I just love and appreciate this so much. And I remember us talking about that and I was like, wow, this is legit. Like he really, he really goes, you know, all in with this, which I just so appreciate.

Dr. Nayan Patel
One more thing, Melanie, is resveratrol. Resveratrol in the whole world is laced with heavy metals. And the thing is, cosmetic companies that sell the resveratrols, guess what? They're all with heavy metals in there. But the thing is, it doesn't go through your skin, right? So it's OK.

That's what they're telling you. But with my technology, I can push it through there. And if that's true, then I don't want to have resveratrol with heavy metals in there. So I really have to find a source, again, another source, then to clean up my raw materials, completely give me metal free. And if I can get those metals, I can use what cosmetic. Again, this is not something that I like to advertise all the time. But it just tells you what I have to do to make sure that I, myself, get clean products to use on my body.

Melanie Avalon
Yeah, well, it's it's super important to me and I know this audience really appreciates it as well.

So yeah, we are we are team we are team what you're doing will taking or using oral glutathione spray and then also the skincare products will by giving our body this exogenous glutathione what will our body produce less.

Dr. Nayan Patel
The answer is yes. I think it will. I think so. Again, I do not know for certain, but knowing the science, I think it will do that part because the body does not do anything excess.

The body senses that you have something. The body says, okay, I can use energy to do something else. I don't have to produce this part because we have plenty of it, right? And so being that I know that part of the science, I'm assuming the body will not have to produce glutathione. And that was the reason why I found out how much to give you, how often to give you, because I never want to shut down your own production ever, right? But I want to replace a lot of the work by giving you exogenous or outside the body glutathione. If I can do that part and still maintain the body's ability to produce glutathione, then my job is served.

Now, keep in mind, glutathione is not a hormone. It's not like if you take an exogenous glutathione and the body stops producing it, the body will forget to make it. So when you really need it, the body will not know how to make it. The example I'd like to give you is when you're building a house. If you build a house, and if you live in Georgia, you build a brick house. If you're building a brick house, I'm just joking, by the way, I live in California, and there's no brick house because of earthquake.

Melanie Avalon
Oh, whoa, I never, wait, I lived in California for 10 years. I don't think I ever put two and two together there. Oh my goodness, I'm having like a real time epiphany right now.

Dr. Nayan Patel
So let's say you're building a brick house. What's the number one ingredient you need? Bricks. The bricks, because without the bricks, there's nothing that's happening.

And so the body does not take bricks from outside sources, right? If glutathione is the number one ingredient in your body, and if you give glutathione, the body goes, no, no, no, I can't take that. If you give me a brick, I'll break it down, make it into a powder, and then I'll make my own bricks again, and then I'll use it to build a house, right? That's what the body does right now. But let's say you somehow you convince the body to give the brick, okay, so you're done. If that happens, and then you got the brick, and it's already made up and ready to go, now all of a sudden, your body says, okay, if I have the bricks, I don't have to make the bricks, I can use the same energy to do the work because the labor force is still the same. If the labor is still the same, guess what? They can do some other work. And what's the labor force in the body? ATP energy, enzymes, and NAD, and amino acids. The amino acids can be used to make a countess of the peptides and proteins. ATP energy can be used to do other peptides and proteins as well, so does the NAD. So you never lose the ability, but the number one ingredient that your body needs is given to you, so all of a sudden, how much labor force do you need now that you don't have to make the bricks? Much, much less. Much less. And that's the reason why everybody that uses a glutathione for the first time, within two weeks, you have surplus of energy, ATP. Because for the first two weeks, the body goes, oh, I have more energy. Maybe I can do this. Maybe I can do that. I can do this. And after that, I say, yeah, I did everything possible, and I just have to maintain it. So now the extra energy, it shows up in the mitochondria, and I say, now, oh, my God, I got energy. I can do better. I can function better. I can walk. I can run. I have the energy to think better. And so all of a sudden, now, every single organ cell starts getting more and more energy. And over time, over two, three, five, 10 years, every single cell in your body is going to have surplus of energy to work with. And that's my goal, right? Not to take over the body's own pressure of glaucoma is to relieve the body of the number one job it does and allow the body to do the rest of the organs and get them better.

Melanie Avalon
Awesome. Okay.

So basically, so while we're supplementing this, our body now has more energy, more time and resources to do other things. And if we stop supplementing, then it will just dedicate time and resources again towards creating it. It's not like it shuts off the glutathione system.

Dr. Nayan Patel
No, it doesn't shut off because the thing is, if you take too much of glutathione, your body will go to a reductive state, which is not a good state. As soon as you do that, the body will have rashes and itching and diarrhea and headaches and things like that.

You know, right away, that something's wrong, right? So you back off anyways. And the dose that we are giving you is not 100% replacement. It's like 90% replacement, maybe less than that. And so that way, you can literally do it twice a day, every day, and never hit 100% from outside sources. You still have to rely on your body's ability to make some. Now, there are people out there that have enzymes, defects, and they cannot make anything. And they need them much higher. And so that's why we created a plus version. And so those plus versions, it's a godsend for them. And so now we have both the regular version for everybody and the plus version for people that have major issues with it.

Melanie Avalon
So listeners, I bet, are super excited to start integrating this into their life. Again, I can't recommend it enough. I use it, well, every single night, and now it looks like I'm going to be using it day and night. We have a 10% discount code for listeners.

So if you go to MelanieAvalon.com slash Auro, that's A-U-R-O. That will redirect to Dr. Patel's website. Use the code MelanieAvalon10, and that will get you 10% off your order. So again, that's MelanieAvalon.com slash Auro, A-U-R-O. Use the code MelanieAvalon10 for 10% off your order. Thank you for that, Dr. Patel. And I really can't recommend this enough. It's a staple, busy staple in my life. And it's funny, so when you, I remember, I remember when I first got the pitch about your book, and I saw the title, and I was really excited because I wanted to learn about Glutathione. And I also saw that you had a company that made Glutathione products, and I was like, oh, is this book just going to be a pitch for his products? And then I read the book, and it just blew me away. I was like, whoa, this guy knows everything I could have ever wanted to know about Glutathione. So thank you. Thank you for what you're doing. Not only are you creating the products that are really changing people's lives, but you're also doing this educational piece, which I just think is so important. Yeah, and you're just such an incredible human being. So if listeners ever go to a conference, because you guys, you're at a lot of conferences, definitely go say hi to Dr. Patel, because he's a, he's a shining figure, you and your wife and the booth and everything. It's just really, really wonderful. I just love it so much.

Dr. Nayan Patel
Oh, thank you so much for that. But again, it's nothing that I'm doing. I have so many angels like yourself that has come into my life and helped me spread this word because we all know, we all know we can only survive if we work together and figure out how to live together, right? If you try to do it by yourself, every single thing, it's not fun, it's not easy, and more than likely you're not going to be able to make it. But if you work together, I think we can all survive and we can all live for a very, very long time.

We've been very healthy. So I appreciate you having me here today and passing this message around. I know there's a part of this about intermittent fasting, so I just want a last foot for thought for people that are doing IF or fastings in general. It's a really, really good thing for a lot of people, not necessarily good for everybody, but it's absolutely an amazing thing for a lot of people. I have done myself intermittent fastings for a very long period of time, and I still do it on a regular basis as well, except for once in a while I may cheat on a Saturday or Sunday with my kids. But other than that, I do practice intermittent fastings all the time.

And with the help of glutathione, my inflammation markers have completely gone down. And so I just want to make sure that people, when you do these kind of things, I want to help people for this community because their goal is to get rid of all these dead cells, the zombie cells, or things like that, and those are mainly for inflammations. And once you get rid of those things, your inflammation will come down. Glutathione is absolutely going to be helping you in this wellness journey.

So please make it part of your routine and please support Melanie for what an incredible job she is doing to spread this word. So thank you so much.

Melanie Avalon
Oh, thank you so much. Yeah, I just think this is one of such a key important thing, especially for people with a fasting lifestyle.

We didn't even touch on this, but in your book, you talk about its role in fat burning and just all the things. What's next for you right now? Anything?

Dr. Nayan Patel
Absolutely. We've been studying for the last few years, another peptide molecule. It's a 3-aminosuccine peptide, GHK. It's called the beauty peptide. The reason is because it is a signaling molecule for your skin cells to do the things to get your skin back to normal or younger. And so with our technology, we will be able to do this GHK copper. We just did a human trial for 30-patient trials and about from patients, for people from 33 years of age to about 70 years of age, something like that. And the results are absolutely mind-blowing.

So I want to make sure that people have access to it. So I am going to fast-track this product, and I'm going to be able to make this product available in the third quarter, sometime in the middle of the third quarter. And so I know this is October, but it's going to be available to everybody really, really, really soon right now. So please watch out for that one. As soon as it comes in, I'm hoping that everybody gets to try it for 30 days and see the results that we are seeing in the clinical trials over here. It's just crazy.

Melanie Avalon
And actually to that point, so a few quick points about it. One, when I saw you at the conference, you had samples of it and I am so excited and it's such a pretty blue color. It's so pretty.

Listeners, stay tuned for episode 448. I'm having Jay Campbell on for that episode and he's like the peptide guy. And I don't think we actually talked about it in that conversation, but in conversations I've had with him and in his book, he's talked about this peptide, this copper peptide and how just mind-blowingly incredible it is for the skin in particular. Because he talks a lot about how most peptides with the skin don't actually do anything or certain forms don't work, but he talks about how this copper peptide is really, really incredible. So I'm excited. I can't wait. I can't wait. I can't wait to start trying it and using it. And that's incredible about the studies. Congratulations, by the way. I know that's a lot to do those studies.

Dr. Nayan Patel
Absolutely.

I think, see Melanie, you go to all the medical conferences so you get a sneak peek when I give to the doctors and so you got early access to it because the doctors had this access for over two years now and they have been raving about this product for a while but the thing is until I see the data coming through it I don't I don't release the products I have to see the data coming in before I release the product to the public and so now the data is in I cannot wait to get this out to the public now.

Melanie Avalon
It's so exciting, I can't wait either. So, okay, fingers crossed.

Hopefully it will be out by the time this airs. If not, stay tuned for it. And I'm assuming it'll be on the website with all the other products.

Dr. Nayan Patel
It will be there. Yes, it will be there.

Melanie Avalon
Awesome. Okay. So again, listeners, friends, go to melonyavlon.com slash auro use the coupon code Melanie Avalon 10 you'll get 10% off site wide there.

That's where you can get that transdermal spray that I love the skincare products, the citrine and then hopefully soon the copper serums the copper peptide. So thank you so much, Dr. Patel. This was so fun. I just I love talking to you. I always just feel so much lighter. You're such an incredible human being and can't wait to see you hopefully soon at another at another conference. Are you going to eudaimonia by chance?

Dr. Nayan Patel
No, because that week I'll be in Mexico. Oh, Mexico.

Melanie Avalon
Hopefully see you at another one soon, for sure.

Dr. Nayan Patel
Yes, for sure.

Melanie Avalon
Awesome. Well, have a beautiful rest of your day and I will talk to you soon.

Dr. Nayan Patel
Thank you so much for having me. Bye. Bye.

Melanie Avalon
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed.

If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team, editing by podcast doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week!




 

 

Sep 29

#441 – Fasting And Smoking, Are 12-Hour Fasts Harder, Fasting Mediterranean Diet Health Benefits, When To Take Supplements, Fasting Social Reactions, Fasting In Older Adults, And More!

Intermittent Fasting

Welcome to Episode 441 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, biohacker, founder of AvalonX, and author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine, and Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC

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Original theme composed by Leland Cox, and recomposed by Steve Saunders.


Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.


TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)



Melanie Avalon
Welcome to Episode 441 of the Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat, with no calorie counting, then this show is for you.

I'm Melanie Avalon, biohacker, founder of AvalonX, and author of What, When, Wine. Lose weight and feel great with paleo-style meals, intermittent fasting, and wine. And I'm joined by my co-hosts, Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC. For more on us, check out MelanieAvalon.com and BarryConradOfficial.com. You can submit questions for the show by emailing questions at iapodcast.com or by going to iapodcast.com. We would love to hear from you. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time, and get ready for the Intermittent Fasting Podcast.

Hi, everybody, and welcome. This is episode number 441 of the Intermittent Fasting Podcast. I'm Melanie Avalon. I'm here with Barry Conrad. Barry, how are you today?

Barry Conrad
Hey, Mel. How's it going? I'm doing great. I'm doing really good today.

It's my weekend here. So I'm feeling pretty relaxed, but excited to be back on deck with you again, which is always exciting. And I'm still in Australia. How's everything going in ATL? How's your weekend been so far?

Melanie Avalon
Things are good. Barry, I wish you could have gone with me last night or the night before, whenever it was, to the event I went to. You might have seen it on Instagram. It was a women and wine event.

Barry Conrad
What happens there?

Melanie Avalon
It was the first annual women and wine event at the Fox Theater, which fun fact, I didn't know this. So the Fox Theater here at Atlanta where I go all the time and see shows, they are the highest grossing theater under 5000 seats in the entire world this year and last year.

Isn't that wild?

Barry Conrad
That's very impressive.

Melanie Avalon
So like ticket sales, wine sales, highest grossing, entire world under 5,000. Like it's a really, it's a big theater, but it's not, you know, like a stadium. Yeah, so kudos to them.

But last night or the night before, I went to this Women in Wine event and they had a lot of wineries represented from all over. They had a lot of local Atlanta, like people who are big in the wine sphere, like Sommelier's and like a girl from like the Sommelimpics and like local wine shops and you got to do tastings. And I actually found, I like went around, I felt really bad because I went, there were so many tastings and I would basically, this is how the conversation would go most of the time. I would like go up to the, you know, the booth or whatever. And I'd be like, do you have any organic wines? And if they're like, they usually be like, well, you know, no, but you know, and I was like, and I'd be like, okay, well, I only drink organic wine, then I would like leave. I felt really bad, I felt like really unsupportive.

So yeah, and then, and the second question was like, do you have any low alcohol wines? And they were just, yeah, I met, I met like this incredible, this incredible woman who works at, or who has a winery called Ancient Oak Cellars in California and she like used to be a neuroscientist and I don't know, it was really exciting.

And then I found this one winery that made these epic wines that were not technically organic, but you know, practicing organic and then low alcohol and tasted delicious and then very, are you ready? So they did like a panel and then they were giving away wines with raffle tickets and I won the first wine. Do you know the moment of like holding the raffle ticket and they like read the numbers and it's like your number? It was like a $500 bottle of wine.

Barry Conrad
That's awesome. What kind of one was it?

Melanie Avalon
It's a Chardonnay.

Barry Conrad
And you don't normally drink, you drink a lot more red, right? So this is a good little change.

Melanie Avalon
Why I'm not going to, so it was, it's called, it's called Morley. Apparently it was like a really exclusive bottle.

I'm going to give it to my dad for Christmas. He doesn't listen to the show, so he won't know that.

Barry Conrad
That's a really good gift. Five hundred dollar bottle of wine, damn.

Melanie Avalon
I know and but like the moment of I was getting like all the flashbacks of childhood when you're like doing raffles and bingo and Stuff. Have you ever won anything like?

Barry Conrad
It's such a good feeling because like, it's like, it's me, it's me. It's like, what numbers is me?

Melanie Avalon
It's okay, I like jumped up like screaming. Everybody's like cheering. I feel like I've like saved the world or something.

Barry Conrad
I could just pick your face you'd be so happy.

Melanie Avalon
Oh my gosh. Yeah. Wait, what's it? What's the biggest thing you've won?

Barry Conrad
biggest thing that I've won. Gosh, like, I think like a meat hamper, which is actually perfect for me because I like me. Oh, what? A meat hamper.

Melanie Avalon
A what? A meat hamper?

Barry Conrad
Yeah, you know what that it like it's kind of like basically like a big thing of me like a basket for like all this Meat like steaks, you know, do you guys have to have meat hampers and stuff? That's very Aussie

Melanie Avalon
oh okay like a gift basket yeah yeah like a meat box like a box of meat yeah

Barry Conrad
Meet hamper

Melanie Avalon
Meat hamper is not coming up like it's like the thing I mean, it's coming. Wait, meat hamper Australia. I'm seeing if this is like an Australian word. This is like a meat hamper, you know, beef. You know what? And this must be Australian because like the first thing that comes up is beef and brew, gift, hampers made in Australia, Australian meat, emporium, gift packs with hampers are artisan hampers.

Okay. Meat mates.

Barry Conrad
All these different things. It's going to be changing soon. You know, the more I, when I'm back home, it'll be all the same. Yeah, that's exciting though. The wine, that's so cool.

Melanie Avalon
It was so fun and it was really nice to be in a supportive community of a lot of women, empowering women and all the things. So it was fun, but you could have come with me and had fun.

Barry Conrad
That's just a woman's thing, right? Isn't it just like, you know, a lot of estrogen?

Melanie Avalon
It was called women and wine, but there were some men there supporting the women. If you like to support the women, oh, oh, and then, wait, actually really quick, my favorite wine that I got, like it was like a man, there was like a lot of men representing the places.

And then at the very end, so not only did I want a bottle of wine, by the end I had a lot of wine in me. And then they just came up and like gave me another bottle. I don't even know who gave it to me, but my friend was like, they said they have a gift for us. And then yeah, they came and just gave us more bottles of wine. And I don't know who gave it to me. I know somebody specifically wanted to give it to us, but I don't know who it's like, it's like secret Santa or something.

Barry Conrad
It's like a wine admirer, an admirer of yours. Yeah.

How good is that? How about you? You know what? I think I may have mentioned this to you, Mel, but early this week, actually, I was walking into the rehearsal room, into the building.

Melanie Avalon
Yes, I'm excited. I was hoping you're going to tell this story.

Barry Conrad
Yeah. And our director for Destiny, the play that I'm doing, her name is Zindzi Okenyo. She's amazing. Shout out to Zindzi.

She was walking up with the headphones on. It's like, Hey, how's it going? It's like, I just finished, I was just listening to you listening to your podcast. I'm like, which one is because the intermittent fasting podcast. And it's like, really? And my face lit up and she had so many genuine questions. She's like, it's so interesting. Wait, so we need to talk about this. And she was like trying to ask all these questions before we got started for the day. And she's like, I actually think I want to give this a go. I have more questions. I'll talk to you at lunch. And so she was super curious about it, but I was also saying to Mel listeners, how people can get, so after spending a bit of time with you, because now we're three weeks in, right? So people see you during lunch break and whether you eat, whether you don't eat and people are like, so I've noticed, you're not really eating, you're not really eating, like what's the deal? And then they start asking and it's like, yes, now I can share about it. But I will say reactions go from shock to offended to curious to like, super curious. So it's really interesting to see people's journey. Cause they see that you're not making it a big deal. And then they start asking more about it. And then they listened to the podcast and now someone else is listening to it as well. So it's great.

Melanie Avalon
So amazing when you and I were talking about it before and you were mentioning it now, it's like you got to let like not them come to you but you know like we don't go out there just like preaching fasting and throwing in people's faces like let the people ask the questions when they want to. I feel like most people come around like as far as like not being shocked anymore at the very least.

Barry Conrad
Definitely. And even Kirstie Morelia was also the playwright. When I told her, she's like, oh, you fast. How long? And I said, 20 hours. And she goes, 20 hours. She was like, she literally like, she was so shocked. And then now she's just so curious about it. She's like, that's so cool. Asking all these questions. It's great.

I love it. I love when people come to us and we have the podcast that we can just say, listen to this and answers all the questions.

Melanie Avalon
And to that point, so like the 20 hours reaction, I remember it's so like interesting to think back on our own lives. Like I remember back in the day when 20 hours would have seemed like so long to me, you know, but now that doesn't even like, I don't even think about hours really.

Like nothing faces me. Remember before you tried like, like way back in the day, 20 would have seemed kind of crazy.

Barry Conrad
And also I think when people realize you've been doing it for a long time as well, that's like, ah, so this is not just like a week long thing like you've been doing for like seven years. Yeah, exactly.

Melanie Avalon
Not a fling.

Barry Conrad
Not a fling. So shout out to, and again, like, I think I can speak for both of us when I say that we definitely do not, as Melanie said, preach to anyone about this.

Like we love this. And that's why Melanie created this podcast and why I'm a co-host. We genuinely are passionate about intermittent fasting. And it's so great when people have questions and they're happy to share, but we never, I don't think either of us lead with, Hey, I'm Barry and I'm an intermittent fasto. Like, it's just, it's not our shtick. And I don't think that's any way to be in general, whether that's any kind of views, you know, like, let me preach at people and hit them over the head with what I think, you know,

Melanie Avalon
Exactly. Like, I'm really fascinated by the concept of identity in general. And I don't, at least for me, I don't feel like my identity should ever be wedded to something that I do, even though I probably do that.

I probably consider actually, I'm like saying this, but then I actually do think of myself as like a podcaster, like a, but but I don't know, the idea of like identity and like, I'm a vegan or I'm a faster, I'm a carnivore is really interesting, because life changes.

Barry Conrad
It does. It really does.

Melanie Avalon
And you don't have to do like one window your whole life either with fasting.

Barry Conrad
I also did say to Kirsty, shout out to Kirsty as well, I said to her, this is a way, it's not the way, like nothing that we do is the way, like this worked for me and I love it so much, but I'm not trying to tell you that you should do it or you have to do it to be happier, to be healthy. I can share why it's so beneficial, but I'm not trying to tell you or preach to you and she was like, oh, that's so true and that's right.

Melanie Avalon
Yeah, exactly. Like, I think if anybody ever says like, this is the only way, especially like diet and fitness, like, probably don't listen to them, or listen and take what's helpful. But you know, be skeptical and congrats on destiny.

So this comes out September 29. So the show will be going on, right?

Barry Conrad
So the show and put it just just finish so yeah you like.

Melanie Avalon
Well, congratulations, very future berry.

Barry Conrad
I know. That's pretty well. The time is flying, so it's going pretty quickly. When you have it.

Melanie Avalon
Having fun. Yeah. All right. Well, shall we jump into some fasting things, speaking of?

Let's do it. So I have a study to start us off with. So this study is called the impact of intermittent fasting and Mediterranean diet on older adults, physical health and quality of life, a randomized clinical trial. So this was published in nutrition, metabolism and cardiovascular diseases, May 2025. So this year, pretty new. And what I liked about this study, so I feel like there can be a problem sometimes, not a problem, but something to keep in mind with a lot of intermittent fasting studies is they'll just look at like fasters versus non-fasters, but then that doesn't really take into account what the people are eating, you know, which sometimes that's the point because sometimes what you're looking for is can just fasting, you know, have certain effects regardless of what you're eating. It's also nice though, if you're eating the same thing, because then you can more tell specifically like the actual effects of the fasting, because the diet is controlled to be the same. And what's interesting about this study is they were looking at they were using a quote, like a healthy diet that has been shown to have beneficial effects and then comparing it, that healthy diet to that diet plus fasting. And the diet they're using was the Mediterranean diet. So the study included, they started out with 20 people ended up with 17. And it was all adults over the age of 60. So this was older adults. And they were given a Mediterranean diet that was tailored to their preferences. So they made sure that it was a diet that they, you know, enjoyed. And it included things like olive oil, fish, nuts, legumes, fruit, whole grains, they were encouraged not to eat refined grains. Let's see what else. The specific things they were encouraged to do was three pieces of fruit per day, whole grains instead of refined grains, legumes two to four times per week, vegetables two times per week, olive oil as the main fat, eating more fish than meat, avoiding red and cured meat, eating three to seven eggs a week, eating two servings of dairy products per day. Interesting. So they had, again, so they had the Mediterranean diet or they had a Mediterranean diet with time restricted eating. And this was not a long fast that they had them do. So the people who were doing the Mediterranean diet with fasting, it was only 12 hours. For me, I would put that at like bare minimum. I feel like 12 hours is right when you're kind of switching over to the fasted state. So it's interesting to me that they found the effects they found, even with such a small fast. And even with not that big of a difference from the control group who weren't fasting, because those people, their fasting time was anywhere from eight to 10 and a half hours. So some of the people in the non-fasting group were still just not that far away from 12 hours. But the average amount of fasting time in the non-fasting group was 9.11 hours. They found both groups, so things in common. They both had improved quality of life. They both had better stool consistency and regularity.

Melanie Avalon
So constipation and digestive issues can definitely be an issue for people. And I think constipation, especially in older adults, can be a problem.

So it's nice that they saw improved quality there. As far as the markers they were looking at, so the fasting group specifically saw significant reductions in their BMI, so in their weight, in their waist circumference, their hip circumference, and their blood pressure. So it seemed that the fasting arm had a greater effect on central adiposity, so that unhealthy visceral fat around the waist, which is really important for health, like not having that. So the fasting had a more beneficial effect on that and also a more beneficial effect on liver health accordingly. Interestingly, they saw a better effect on GGT in the Mediterranean diet. And GGT is a liver enzyme that can be elevated and it was actually not, it was benefited more by the non-fasting group. And I was really hoping that they would comment more on why that might be, but they didn't really. All they said was that the significant decrease in GGT levels in the Mediterranean diet group, compared to the fasting group, aligns with the results of a meta-analysis conducted by Sanguini et al., which reported a significant reduction in GGT levels across the eight included studies. So the conclusion of the researchers was that both of these approaches, so just the Mediterranean diet and the Mediterranean diet with fasting, had positive effects.

So they, just in general, they positively influenced various health conditions and individuals over age 60. That said, specifically the fasting group resulted in significant reductions in BMI, waist, hip circumference, and also systolic blood pressure. Something though that was interesting was the Mediterranean diet group only. So the non-fasting group, 100% of them wanted to keep going when it was done. They felt like they could keep going and adhere, but only 20% of the fasting group did. So I'm really intrigued by this because in the past, I feel like in general, one of the benefits of fasting type approaches is adherence usually tends to be high.

I've seen so many studies on this where when people do fasting, they are really able to adhere to it without wanting to drop off or stop doing it. And so something I wonder, so they have some ideas that they proposed for why this may be. This study took place in Spain, and they said that Spain actually has one of the longest eating windows anywhere. So they start eating at like 7 a.m. normally, and they tend to stop eating it. They'll have dinner at 10 p.m. So the population is a population that is not used to the fasting type approach. It also might be that older adults have problems adhering to the fasting approach than younger populations. And then my theory about it is, this is my theory, is because they were putting them on a Mediterranean diet, I would imagine that that naturally, because now they're switching to like a whole foods type diet, a healthy diet,

Melanie Avalon
they probably naturally were calorie restricting, or at least compared to what they were before. So it could be, I have a few theories, it could be that the, you know, switching to a diet that would create more of a calorie restriction and fasting, which is too much for them to adhere to. And they're older and they're in Spain, where they're used to eating all throughout the day. But basically, so I found it really interesting that there were more beneficial effects in the fasting group.

And yet they, you know, were not so much down to continue doing it, only 20% wanted to keep doing it. So yeah, Barry, do you have thoughts on this?

Barry Conrad
That's such a great study, and to echo what you just said just now, I think that's really surprising because you say that the Mediterranean diet group who also fasted was only 12 hours, which is not long.

Melanie Avalon
Yeah, that reminded me of my other thought, which is like, maybe they weren't actually getting into the fasted state enough to get the appetite suppression effects, you know? Because it's like, if you're just like, if you're right at the cusp, but you're not actually really getting into ketosis, because you're not fasting long enough, then you're probably just going to kind of feel the misery of not eating without it, without it becoming easy. So in a way, like, fasting less can actually make it harder, I think, for some people.

Barry Conrad
Definitely. It's not surprising. I mean, it is, but now that you said that, that's a good point. You're just not there yet.

You haven't really switched into that state. You're still in the struggle street state. Because it's only what? Nine and a half hours on average for the nonfasting group and then 12 hours for the other year. That's not much time difference at all between the two.

Melanie Avalon
I almost wonder like if they have been fasting in the fasting group like 14, 15, 16 hours, would it have been easier for them? I think it actually might have been.

Barry Conrad
I had a thought when you're talking about the blood work as well.

My mom actually told me just two days ago that she started intermittent fasting.

I think I told you that, but she just got her bloods done.

And she said, she's like, I've just got my bloods done.

And they're like, amazing.

Like the best they've ever been.

And when I did them last year, they were not great.

And the only thing that I've changed is now I'm consistently intermittent fasting.

So,

Melanie Avalon
Oh wow, amazing.

Barry Conrad
It's amazing. She said it's definitely the fasting. That's really encouraging.

It's great that the BMI went down. It's great that they're still finding these benefits, even with just the 12-hour fast. It just goes to show you don't have to, even though, yes, maybe you're not feeling like you're in that state because it's 12 hours, there's still benefits. Non-scale.

Melanie Avalon
So yeah, it's like, it's funny, because we're saying both things. We're saying like, maybe the less fasting made it harder. And maybe they would have seen more benefits.

But still, like you said, literally, they said, TRE, so time restricted eating combined with the Mediterranean diet offers superior health benefits compared to the Mediterranean diet alone. So they still saw benefits even with not that long of a fast. And something of note, that's something I was going to note was was going to point out they did, like teach the people how to ease into fasting. So they did like counsel them on how to do that.

Barry Conrad
I wonder how they show them that. I wonder how they demonstrated it or if they just sent them a document to read or how that worked.

I can tell you. Let's see. I also thought it was really interesting about the GGT and why it improved a bit better in the nonfasting group.

Melanie Avalon
So GGT, I know it's related to muscle. It's like it's a liver enzyme

Barry Conrad
But I wonder what the difference would be if it's just a few hours, essentially.

Melanie Avalon
So it's an enzyme primarily found in your liver. It's also in your bile ducts, your kidneys, your pancreas and your spleen. It plays a key role in the transport of amino acids and in the body's glutathione metabolism, which is crucial for detox.

Let's see. So, well, TragiBT is saying that fasting can potentially affect GGT, but usually only mildly and not in a way that's likely to cause major spikes or drops. Yeah, I really wish they had commented more on it because I found that really interesting but they kind of didn't really talk about it. To answer your question about how they were taught to do fasting, and before I say that, just because I'm reading now, they said they chose a 12-hour fasting period because it is less restrictive than shorter eating windows and it aligns more closely with typical eating patterns, making it easier for older individuals to adopt and maintain. They were guided through a structured process. So they had a consultation and then they got detailed instructions on how to gradually adjust their meal timing. So for example, because they got to pick their eating window, so if they typically ate from 7 a.m. to 9 p.m., then they were advised to make their first meal 8 a.m. and 8 p.m. and then slowly, well, I guess that would have done it. That would be a 12-hour window. But so they were advised on how to shift it down.

Barry Conrad
This isn't related but not, but this week we had our first, well this will be in the past now, but when we had our first full run-through of the play and they introduced actual edible food because there's scenes where we're actually eating, like there's something called a...

Melanie Avalon
Can you actually eat on stage?

Barry Conrad
you actually eat. So there's a, it's something called a Bri in South Africa, which is a barbecue. I've talked about that before. And basically we had like baked potatoes or barbecue potatoes. And I just decided I'm going to do it. It was like, I want to say, it was like 10 30, 11 AM in the morning. But I thought for the sake of everyone is using drinking the liquids and eating the foods for the purpose of the scene. So it was like, I'm just doing it today, but I'll tell you Mel, as soon as I had that one bite of potato, for the rest of the day, I was in agony. It was like, Oh, I'm so hungry. And just again, I'll let it again. Like I don't think about, I do not get hungry when I'm fasting. I don't.

Melanie Avalon
It's so true. And it's wild how like the one little bite can because it starts back up that digestive system, messes with your insulin, like it's kind of crazy to me, you know, and people might not understand if they haven't tried fasting, they're like, Oh, how can one bite, you know, matter?

I'm like, Yeah, I just need to stay in the fastest state in my good my good zone.

Barry Conrad
But that also again relates back to the group doing 12 hours, maybe it's just not quite enough time to get past that feeling of like, I'm hungry, you know.

Melanie Avalon
Yeah, that's what I feel might be happening. So, okay.

Barry Conrad
Great study, Mel.

Melanie Avalon
Thank you. And also congrats on your first full run.

Barry Conrad
Thank you, thank you.

Melanie Avalon
I mean every, every episode, sorry, every show you eat on stage.

Barry Conrad
Yes, there's a scene where I drink quite a lot, but it's just water and a beer bottle, which is fine, which is fine. I also, by the way, I also have to smoke on stage.

Melanie Avalon
Wow, you know what we should talk about the question that was related to that actually like actually spoke like cigarette spoke

Barry Conrad
So with theater, and they do this in screen as well, they have like menthol cigarettes. So it looks exactly like a cigarette. It's not completely foolproof.

So I'm going to talk to them to see if there's another option as well, because the menthol, it kind of inhibits that it makes you feel like you can inhale more smoke because you don't feel that, that, you know, nicotine in that, that tobacco. So that can still be damaging if you're inhaling so much more, because it's easier to smoke, but I have to smoke in the, the play a couple of times. Yeah.

Melanie Avalon
Oh, wow. So it's is so it does have it is like smoking, it's just less of the stuff.

Barry Conrad
It's like menthol, I need to, it's not technically toxic, but I think cause you're inhaling more smoke easily, it's still going to make you more prone to.

That's not great.

So I'll see if there's another solution, but it's, I got to do it for the.

Melanie Avalon
looked it up. Yeah, I just looked. I just, I just asked Chad about it. It says menthol smoking is toxic with some added concerns. Oh.

Barry Conrad
Oh gosh, okay.

Melanie Avalon
All cigarettes contain harmful substances tar carbon monoxide formaldehyde benzene ammonia arsenic whoa hydrogen cyanide I didn't know that what menthol adds menthol is a chemical that gives a cooling menti sensation it doesn't eliminate the toxins it just masks it increases nicotine absorption.

Barry Conrad
Well, I'm going to ask if, because I know there's two different options, but that's the one that they cost. Well, that's not great because I used to be a smoker. I think I've told you this before.

Melanie Avalon
Yeah, they're banned in the European Union and Canada.

Barry Conrad
Really?

Melanie Avalon
uh-huh

Barry Conrad
So, listeners, don't do as I do. I'm doing this for a role, an acting job, but I'm going to try to see if there's a different solution or a different type of cigarette, because I do need to smoke for the play, but...

Melanie Avalon
Yeah, we did not plan this. But we have a question about this. We didn't plan this at all. Should we do the question about this?

Barry Conrad
Let's do it. So Amy sent an email in and the subject heading was smoking while doing IF. And she's like, I know, I know. Smoking is bad, but this is a question from my husband who wants to start doing IF along with me.

He is doing OMAD and eats around 6 to 7 PM and doesn't have any snacks. But he tends to smoke throughout the day. So is smoking during his fasted period? He is doing IF for weight loss purposes, because clearly he's not too healthy if he's still smoking. Anyway, does smoking increase insulin slash break a fast? Should he increase his eating window and only smoke during the window? Melanie, what do you think?

Melanie Avalon
Really good question and interesting. I don't think we've received this question on the show before and like over 440 episodes and the answer is gonna be really interesting at least I think it is so smoking I mean, I think most people are pretty much aware that smoke like smokers tend to be thinner and Smoking is linked to weight loss and there's a few different reasons for that but nicotine itself Seems to have a lot of beneficial effects on Weight specifically so it has a an appetite suppressing effect nicotine does it affects energy expenditure in part by actually it actually can encourage the formation of brown adipose tissue and Like it affects the the regulation of energy there and what brown adipose tissue is it's it's basically called brown fat And it's a type of fat that actually burns calories for energy So it's a healthy type of fat So nicotine has a beneficial effect by increasing energy expenditure in that type of fat in your body Again, and then it can also turn white fat into that brown fat but also could help with glucose regulation and it can increase just energy expenditure in general and The way it does this it might do this by affecting activity in our hypo thalamic Neuropeptide system in our brain also by affecting AMPK, which is something we talk about a lot in this show But AMPK is an energy sensor mechanism in the body that it's activated by fasting.

It's protective of longevity nicotine might actually like increase those levels and this is a reason that I think smoking tends to be Ironically, it's been linked to longevity in certain populations like certain Centenarian populations Some of them it's thought that like there's smoking might actually be having a beneficial effect.

I know this is really controversial and wild I'm not seeing the smoke smoking isn't that good? Congratulations, by the way, very on quitting because I know that's you know, really hard and not easy to do and at the same time Nicotine does seem to have beneficial effects.

I Like the dopamine effect from it. It's preventative of Parkinson's maybe preventative of Alzheimer's so this is a long way of saying that nicotine itself and because you're getting nicotine from smoking it actually May help weight loss.

It's not gonna hurt your your weight loss effects Does it break the fast? No, it doesn't have calories in it And if anything, it's like I said helping you burn fat And I know that's a really like ironic a controversial answer, especially because you know, you're saying Amy for your husband. He's doing IF for weight loss Because he's clearly he's not too healthy if he's still smoking So yes the smoking very unhealthy not good That said smoking is probably actually helping him in his weight loss efforts So just as like a heads up if he stops smoking, you know, he might gain weight He might find it harder to lose weight So he might want to try a like a nicotine type patch approach, especially if he's weeding off and then as well The smoking itself is not gonna break the fast.

Melanie Avalon
That said the opportunity I see here is If he's just smoking in his eating window, then he's cutting down on smoking, which is great. So I almost wish it did break the fast because then you could be like, oh you can't have it while fasting because You know because then that would be a way to kind of like help cut down on the smoking So should he only smoke during the window? I'd say yes because that's Gonna help with his health and getting off of smoking.

Does it break the fast? No.

What are your thoughts Barry?

Barry Conrad
Oh, you answered that. You nailed that. Mel was so great at exactly what you said.

Smoking, it doesn't really, it doesn't trigger an incident response like carbs or anything else. So it's not technically breaking it as a former smoker. It's really, really hard to quit. It took me three times to quit, but it's so worth it. I think that baby steps and progress over perfection. So I think, no, I think I know it would be beneficial for him to stick to, or to try smoking within his eating window. Cause as Mel said, it's going to help him maybe wean off it over time. And also, yeah, you'll just be smoking less, which means better health. So there's nothing more that I can really add to that, but it is really interesting how I did not know that it had all those benefits as well.

And all like nicotine. And also it made me want to ask, how did you, and why did you want to start wearing a patch? Like who told you about it? How did you find it about that? Do you really notice much of a difference? Yeah, that's interesting.

Melanie Avalon
I have a question for you as well about your experience quitting. But to answer your question, when did I first start using nicotine patches? I've used them for a long time.

They're actually, they're kind of, they're one of the things in the biohacking world that people experiment with. I think I probably just heard about them on different podcasts. Like I know Dave Asprey has talked about them a lot as have other like biohacking type people. And I've like seen the beneficial effects on them for like the studies on them for being preventative for cognitive decline and Parkinson's and the way for me personally, cause I think, I think when it comes to any sort of substance, so alcohol, nicotine, marijuana, even like psychedelics, like they're all these different caffeine, like all these different substances, some work well with people's body chemistry, some don't, or even all the, even like pharmaceutical drugs, like, you know, people who are, take like Xanax or something, like people react all differently to different substances. So I think it's important to know things important to like weigh the cost benefit of things, the harm or not, you know, how addictive is it to you? How does it make you feel? Like again, what is the cost benefit? And when it comes to nicotine patches, I can't, like you don't have the carcinogenic effect of smoking. Yes, it can be addictive at the same time. You don't have the addiction, social cues of smoking. So it's not like where, cause a lot of, I've, and I'd be curious your thoughts, your thoughts on this, but from what I've read, a lot of smoking addiction, a lot of it can be the, like you're used to like having a cigarette and like that, like that activity itself becomes really addictive in addition to the nicotine, whereas like with a patch, if you've never smoked and you're only doing a patch, you just put a patch on or don't put a patch on. And you can like titrate up dose or titrate down dose. So you don't have that, that environmental social thing that comes with smoking that I think can be really hard for people to get through. But I just really liked the way dopamine makes me feel like it makes my brain really alert, helps me focus. Yeah, I don't see any, I don't personally experience any negative effects from it. And if I were to not put one on, I probably wouldn't notice if that makes sense. So like, I like the added benefit I get, but if I don't put one on, I don't really, it's not a big deal. I will say if you experiment with the nicotine batch, start slow, because if you just, you will get sick if you put on too much, trust me. And I didn't realize it the first time either, because I put one on and I, and then I got so sick, like I was like throwing up and I was like, what is happening? I haven't, and then I was like, oh, so yeah, be careful. When you quit, what was the thing that, because it's that you said it took you three times, what, like what actually did it for you the third time?

Barry Conrad
Thanks for sharing before as well. I'm really curious to maybe even try out this patch situation.

Melanie Avalon
I love my nicotine.

Barry Conrad
The three times were in a pretty short-term succession, like I tried three times, but the biggest kicker for me was my voice and my career and health. I'm so passionate about my health and fitness and always have been.

I'm like, long game, do I want this? Do I want this to be in my life long-term? No. So, I just kind of had to do it. Like the why became bigger than the habit.

Melanie Avalon
Yeah, totally makes sense. It's funny.

So when I was looking through my goodie bag from the last biohacking conference they and one of the things in it because they gave us like a lot of things. One of the things was actually like nicotine, like chewable things. I actually haven't tried it because I've actually never tried like a chewable nicotine. Maybe I should try it sometime.

But I just think it's funny that that was literally in like our biohacking like gift bag.

Barry Conrad
And so I need to try these things. I just had no idea that even the patch was a thing. Like you could wear one just to like, do you feel, is it like a, is it a slow release since like, what's the situation?

Melanie Avalon
I buy a 21 milligram patch and I cut it into four.

So, you know, a little bit over three milligrams and it's slow release.

And that's, so it's a tiny amount that I'm putting on.

I've done more than that in the past, but interesting.

Yeah.

And it feels for me, it just, it's kind of just like a little, like, little dopamine, some good focus, you know, feeling productive.

Barry Conrad
Well, Amy, we hope that that is helpful, and good luck to your husband. Hopefully that'll keep us posted.

Melanie Avalon
Yes, please, please do, please do. I wish you could tell them that it breaks the fast, but to be super clear, I'm not saying to smoke. Smoking, not good. Carcinogenic, not good.

Barry Conrad
Isn't that so interesting that this is the first, like, I'm surprised. I've actually never thought of that, of people asking those questions like, does smoking break the fast? No one's ever asked that before.

Melanie Avalon
If anything it supports the fast ironically because it i don't want to say that but you know it helps you burn fat increases energy expenditure it kills your appetite that's why just try nicotine instead if you want those benefits.

Barry Conrad
my mom's side of the family, Mel, like smokers, like really, really smoke. And they always used to say, yeah, it doesn't make me angry.

I could just, I just have to just keep smoking. I don't get angry. You just like, you know, they just smoke away.

Melanie Avalon
I mean, a lot of people, that's why people, you know, stop smoking and they gain weight.

Barry Conrad
We're not sent to smoke, everyone just saying disclaimer or not, yeah.

Melanie Avalon
I know, I know, I have to be so clear about that.

Barry Conrad
Okay, so Kimberly on Facebook asks when to take supplements. I overthink this.

Melanie Avalon
Awesome question, Kimberly. So it is very easy, I think, to overthink this one. And it's still it's still a really good question. And there are things to keep in mind.

So most supplements, I mean, you really want to look at ingredients and make sure they don't have, you know, things in them like maltodextrin, which is a form of sugar and, you know, oils and toxins and things like that. So you want to get really clean, pure supplements. But as far as like when to take it, the way I look at it is, if it's like a food based supplement, I tend to take it with food. So like, if it's magnesium, I'm like, I take that with my food because it like adds the nutrition, I actually take the vitamin, I take vitamin D with, because that's something we would be getting, well, we get that from the sun, but we also can get it from food. I actually, because it's like fat soluble, take it with my food, even though I then I take it at night and vitamin D they'll often say to take during the day because of its effects on circadian rhythm. But like spirulina that I consider a supplement I take with my food. So food related nutrients, you can take, you know, with your food. Things like mycelia peptase, which is great to support the fast, break down problematic proteins in your body, clear your allergies, take that in the fasted state, preferably right when you wake up. Something that's really going to help you with blood sugar control like berberine, you're going to want to take that definitely before meals to help with the blood sugar response of the meal. When it comes to things like just neurotropics or, you know, like adaptogens to not ever think it, I would just look at the bottle. Like when does the bottle say to take it and take it accordingly? I interviewed, so Jay Campbell, I had him on the Melanie Avalon biohacking podcast. He's also going to be coming on this show as well. He's really big with peptides. He does make a really strong case in his book, one of his books, that if you really want the full beneficial effect of a supplement, that it should be taken not with other things, which I know is hard when we're taking like a million things. But if you're taking something specifically for like fat burning or like peptide related like that, isolating it is going to probably give you a more potent effect. But again, it's really hard to do that when you're taking lots of things. But so like my daily supplement routine, the ones I think are really important about timing are like seropeptase in a fasted state, really important. Burberry, making sure that it's before meals, although I also take it in the morning to the morning, the afternoon when I get up to support the fasted state. Obviously, things like digestive enzymes and HCL, anything that's food support will be taken with your meals. Circadian rhythm related things like melatonin or magnesium, my magnesium nightcap, which crosses the blood-brain barrier you can take in the evening to support your sleep.

Melanie Avalon
So really, yes, don't overthink it. Look at the supplement and ask yourself what is this supporting? Is this supporting something about the food and digestion? Then take it with the meal.

Is it supporting my sleep? Take it in the evening.

Does it need to be on an empty stomach like your thyroid medication or seropeptase on an empty stomach?

I'm trying to think there's any other like big blanket categories of things. I like the way she started though, which is don't overthink it. You can always just look at the bottle.

What do you think, Burry?

Barry Conrad
When it comes to supplements or medication for that matter as well, I just follow the bottle. Like, I'm not going to overthink that at all when it comes to that.

I think if it's something that you're taking by choice, which is not like a medication that's more of a supplement, then yeah, like Mel said, food-related, take it with food. If it's not relevant to that, I do like the idea of what you said. What was the guest that you mentioned before, Mel? The guy that talked about? Jay Campbell. Yeah, I love the idea and I really agree taking... To me it makes sense that isolating those kinds of supplements would be more potent. You don't think? Because I think that makes sense to me.

Melanie Avalon
Yeah, and like things like, if you're taking some sort of like fat burning supporting compound, which there are quite a few different supplements out there, you might want to, you know, take them by themselves. Also, if you're evaluating how something makes you feel, like nicotine, for example, you probably want to take it for the first time when you put it on like not with other things so you can see, you know how it's making you feel.

I feel good because I just I was curious and I put in chat GPT, like when to take supplements and I feel like I did cover because I was like, I feel like I'm making this specific to me, but I think those are the pretty big categories, like some things I left out. So B vitamins. So those are going to be energizing. That's something to keep in mind.

Like is this energizing? If so you want to take it earlier. So B vitamins might be energizing.

Barry Conrad
melatonin, take it at night, you know?

Melanie Avalon
Yeah, something like zinc that going back to like taking with food people sometimes sometimes get nausea from that So you would want to take that with food other ones at night might be like L theanine CBD or I left that out CBD Gaba, you know, those are gonna help with sleep probiotics.

I would probiotics. I would take with food unless it says Not to so like seed probiotic, which I adore It's one of my favorite probiotics of all time that you're gonna take on an empty stomach is how they say to take it I will give you a link for that by the way you

Barry Conrad
Yeah, and even things like, I guess, fish oil or spirulina, like, you know, you can clearly also see the food related, so probably take them in my eating window, you know?

Melanie Avalon
The fish oil one is really interesting and really quickly so for seed which is my favorite probiotic seed.com slash if podcast with the code 25 if podcast will get you 25% off.

The fish oil is so interesting because historically I always thought taking it with food and that's what chat GPT is saying and still I've read some of the people and I'm running together in my head who said what but some books that I read they say fish oil like take it in the fasted state and then some say only take it with food so fish oil I'm really on the fence I personally would take it with food though.

Barry Conrad
Yeah, but it is a really good question, and actually it seems simple, but I'm glad that she asked that. So thanks for your question.

Melanie Avalon
Yes, awesome, awesome. Shall we break our proverbial fast?

Barry Conrad
I think we should do it. I'm so excited about this restaurant.

Melanie Avalon
Okay, Barry, I am so excited. What restaurant do you have for us today?

Barry Conrad
Okay, so I have chosen a restaurant that I think you're going to love. It's called Carbon, I think it's pronounced that way, and it's based in New York City.

Melanie Avalon
Oh, I know you gotta start and you can go to these places.

Barry Conrad
Exactly. So, this place, why it's special, it's got a retro chic revival of mid-century Italian-American dining situation from a major food group, and it was opened in Greenwich Village in 2013.

It's got ala card gems like Spicer, Rigatoni, vodka, and veal parmesan. Each plate rendered with theatrical polish, which I think you'd like, Mel.

Melanie Avalon
with what? Theactrical?

Barry Conrad
Theatrical polish like theatrical flair.

Melanie Avalon
Oh, oh, okay. Oh, okay. I thought you were saying like, like a literal substance that was called theatrical polish. I was like, what is theatrical polish? I want it, but yeah.

Barry Conrad
Nearly every dish is table side plated, which I actually love that idea, which marries nostalgia with modern hospitality and one of the things you're going to love is the wine list is extensive and Italian selection.

Melanie Avalon
Table-side all of them table-side plated almost that's cool

Barry Conrad
Yeah, and the vibe which haven't been yet but apparently it's like a dark leather booth with emerald bank bank it's set against glossy white tablecloth tops perfect for indulgent date nights or lively group dinner so sounds like my kind of place have you seen a looking at it.

Melanie Avalon
Yes, I'm at the I'm at the website. The yeah, the vibe is totally oh Locations they have another location.

Oh, New York, Miami, Dallas, Las Vegas, Hong Kong, Doha, Ria Coming soon to Dubai and London. I want to go

Barry Conrad
Well, when you come to New York, this is great because we could do this and I can come to the ones in Atlanta. I know. Let's go to the dinner menu and see what we got there.

Melanie Avalon
We get to use Italian words for the category so we don't have to fight over, like, entree appetizer-ness.

Barry Conrad
The mains, entree, yeah.

Melanie Avalon
Okay so antipasti.

Barry Conrad
Antipasti, anything they're grabbing, catching your eye.

Melanie Avalon
actually yes I want the okay so actually I want two things I want the prosciutto and melon will you eat the melon

Barry Conrad
Yeah, definitely.

Melanie Avalon
And then I want to taste a baked clam, but I don't want the whole thing.

Barry Conrad
I knew you were going to say that.

Melanie Avalon
I've never had, I don't think I've had clamps, which is, I think we've talked about this.

Barry Conrad
Yeah, we have. I'm getting the deja vu, but also I can't remember why you said no.

Melanie Avalon
last week we talked about the bubble room at Sanibel and like clams are on probably every menu there of all the restaurants but growing up I didn't like fish like I didn't like fishiness and then by the time I realized it

Barry Conrad
Ah, here we go again.

Melanie Avalon
Yeah, Barry does not like it when women say, say that bitch is bitchy.

Barry Conrad
It's fish, it's, it's, it's, can't taste chickadee or steaky.

Melanie Avalon
days of it fishy captures the like the negative aspects of the sea you know like the fishiness so I haven't had clams because I like didn't have fish stuff or seafood growing up and then I just never by the time I don't know by the time I was eating fish which I love I just wasn't like eating clams like they're just not they're not on the menu a lot I don't think they're on this I feel like they're gonna taste like a scallop but they're not scallops right so I don't know

Barry Conrad
It's very, very similar actually.

Melanie Avalon
Are they sweet like scallops?

Barry Conrad
Yeah, they're sweet. They're not better at all. They're really easy to eat. Really delicious. Same consistency. Really good.

Melanie Avalon
I would like to get those and hopefully I like them. And if not, you can have them.

Barry Conrad
Sounds good to me. What do you want?

Melanie Avalon
Oh, wait, wait. Oh, I miss carpaccio Ah backtrack. I don't want prosciutto anymore. I want carpaccio. I love carpaccio

Barry Conrad
I am going to go the calamari Marco. I love calamari so much. And also I'm going to go for the assorted baked clams. I just, they're delicious. They're so good.

Melanie Avalon
So I think we should get one order and I'll taste it.

Barry Conrad
I wonder how many you get.

Melanie Avalon
And then if we like it, we can get another one.

Barry Conrad
Get another one and you know and this is kind of a wild card which you won't be expecting me to say no but i'm also gonna get.

Melanie Avalon
Wait, wait, wait, can I guess? Well, there's one thing on here that would be like super wild card. Is this like super wild card?

Barry Conrad
Yeah, kind of. I've never actually ordered something like this before in all the episodes we've done.

Melanie Avalon
eggplant and zucchini. You got it. I know you so well.

Barry Conrad
You do, but the reason why I am choosing this eggplant, Mel, is this week I did an episode of banter with BC with my co-star, Kirsty Marillier, for Destiny, and it was presented in such a way that A, it didn't look like an eggplant, B, it tasted amazing. It's kind of, it was like two, imagine two rectangular type tubes on a plate, like marinated, like meaty, like not soft, like just really good, like really, really, really delicious.

At this place called Miss Pearl, it was so good, it was amazing, loved it.

Melanie Avalon
You know the problem with eggplant and zucchini, right? Like why I haven't is, wait, let me check if zucchini is. Let me pull up my app, FoodSense Guide Shameless Plug. For friends, if they're curious, if you get my FoodSense Guide, it is a comprehensive catalog of over 300 foods for 11 potentially problematic compounds.

Oh, okay, zucchini is not this. Okay, that's cool. Eggplant, though, is a nightshade.

Barry Conrad
So explain why that would be bad for me, or bad for you, I should say.

Melanie Avalon
I don't want to like add any sort of food fear. So if you're not feeling, if you're not having issues with it, just don't even think about it.

Some people though have problems with nightshades and they contain a compound called, I think it's called, let's see, I'm literally looking in my app. So the compound is called, it's the family solanacea and there's a compound in nightshades that people, if they struggle with them, they might get like an inflammatory response, arthritis, things like that. So common nightshades are, eggplant is a big one, tomatoes, potatoes, paprika, goji berries, bell peppers, sweet peppers. So if you notice that you react to those foods, you might have a problem with nightshades.

Barry Conrad
So, Mel, can I just say something that's going to be really good for me to say? Paprika, tomatoes, potatoes, what do those things have in common? Me, I love them so much and I eat them so often, like on the daily.

Melanie Avalon
and you don't react to them that you're aware of. No. Yeah, so you must be good with nightshades. Me for you. I would be curious if you stopped eating all of them if you notice anything.

Barry Conrad
That's so interesting because I think I was raised with a lot of potatoes and a lot of tomatoes. I don't know if that's an epigenetic kind of a situation or even just like a conditioning situation, but yeah, I don't have a problem with them, I guess.

Melanie Avalon
Well, that's good. So all the eggplant and zucchini for you. And I don't know how to say the word, scap, scap. We've, if we know one thing is that we butcher language on this show.

Barry Conrad
Didn't you say someone said, it's so funny trying to hear you and Barry?

Melanie Avalon
Oh yeah, they liked it. That made me happy.

Somebody in the Facebook group commented on us trying to pronounce things and I don't remember which area of the geography world we were trying to pronounce, but we did it really poorly.

Barry Conrad
We're not gonna guess it, but it was, yeah, it wasn't great.

Melanie Avalon
But she said she liked it. This is eggplant and zucchini.

Barry Conrad
I want to say, I could be wrong. Please don't come for me guys. I'm trying.

Melanie Avalon
Okay. Are you going to get a super salad? I can read that. It says zupa e insalate. I don't know. It means soup and salad, right?

Barry Conrad
Yeah. I think I'm going to get... Oh, actually, I do like a good minestrone, actually.

Melanie Avalon
Okay, I'm gonna I'm gonna pass

Barry Conrad
You're like, okay, yeah. Okay, what would you like to get from the macaroni?

Melanie Avalon
Okay, I feel like now is where we enter entree territory entree slash main territory because there's macaroni so like pasta options there's pesky so the fish options oh I see what I want and the carny. Okay, and then it's like sides okay I see one of I see on this menu Barry one of my favorite meals to order at restaurants ever and I get so excited when they have it so we're in a good spot right now.

Barry Conrad
That's really good. What's catching your eye? Tell me. I want to know what it is.

Melanie Avalon
I mean, you can completely get rid of one whole category, so that helps. I don't think you know. I don't know if I've talked about this on the show.

Barry Conrad
I feel like you're going to get rid of the macaroni one.

Melanie Avalon
Yeah, so no pasta.

Barry Conrad
And if you haven't talked about this on the show.

Melanie Avalon
It's something from the fish department.

Barry Conrad
Okay, let me think about this.

Melanie Avalon
And I can I give you a hint. I feel like a reason I love this dish is because it makes me feel very like ancestral and it's like a whole experience and I feel very primal eating this.

Barry Conrad
Ahol, Bronzino.

Melanie Avalon
Yes.

Barry Conrad
Yes, I got it right.

Melanie Avalon
I love whole brands, you know, it's like one of my favorite things.

Barry Conrad
Describe it for me.

Melanie Avalon
So have you had branzino? I have not.

Oh my goodness. So it is, I'm pretty sure it's lower mercury. It's this delectable, delicious white fish and they normally serve it whole. So there's like the, like the whole thing is there like the head and everything. And it's, it's just like, I was going to say moist. No, I'm kidding. I'm kidding.

Barry Conrad
Now that you know that's bad.

Melanie Avalon
Now you don't like it. Okay. It's very luscious. Is that okay? Luscious? Is that word okay?

Barry Conrad
Succulent, luscious, delicious.

Melanie Avalon
luscious, delicious, like this white meat, also still kind of lean. And you get it in the whole fish form. So you get to like, like I said, feel, feel like primal. And you know, if the, if the head is there, you can like eat the brain.

Barry Conrad
You eat the brain.

Melanie Avalon
If you want if the head is there

Barry Conrad
You're very surprising to me sometimes, Mel, because I know that you, because you listeners, you probably heard us talk about this before, like how we'd eat, you know, in front of people. And Mel was like, you want to take little bites and kind of like, she's like, I wouldn't cover my mouth, but I mean, this is like, um, this is a primal experience. You'd be using this like bones and the whole thing and eating the brain. I just can't picture it.

I'm trying to, I'm trying to picture you navigating this dish.

Melanie Avalon
I feel like I feel like we need to, yeah, we need to go to a restaurant where I can get order this because we can go here. We can go to carbon.

I like that you called it carbon. Isn't it carbon? Has an E at the end. I did say carbon, didn't I? Are they like carbon? Maybe, I don't know. Your accent kind of like changes it around. But yes, I love the whole, and I know, I know, I'm pretty sure I've talked about this. Like Barry, when you're back in New York, you can go to Whole Foods and you can get a whole branzino at Whole Foods and you can cook it.

Barry Conrad
Is Bronzino there?

Melanie Avalon
Yeah, yeah, yeah. They'll debone it for you.

Barry Conrad
Oh my gosh, it's all happening.

Melanie Avalon
at the fish counter for free, and then you can cook it. And so it'll still be the whole brands, you know, like it'll still have the skin, the head, the eyes, I don't eat the eyes, but they'll have everything but it won't have the bones because the bones are where it gets tricky because you're like eating and then you literally impale your mouth. It's a vibe.

So that's why I feel about whole brands, you know, so I'm getting that. And I probably want some meat too. But is there a fish that you want?

Barry Conrad
Well, the way that you describe me that is pretty good, but I'm not going to get the same thing. So I reckon I'm going to go for the Lobster Fratia Volo.

I love Lobster, so I reckon I'll go for that baby and then for sure.

Melanie Avalon
What fraud Diablo is like so do we know what that means Barry and I do this show so we can get educated on Like what things mean on menus? Oh It's like it looks like a pasta

Barry Conrad
like a pasta, I'm not mad at that. I mean, I would have that.

Melanie Avalon
Oh, it has a tomato sauce berry. This is your dish. This is your dish.

Barry Conrad
It's my dish.

Melanie Avalon
This is like literally your dish though

Barry Conrad
It actually is, yeah, I definitely get that. And then what about from the Carney menu, Mel?

Melanie Avalon
Okay, so this looks so good. I would like... Oh.

Barry Conrad
It's so funny. Oh, it's like a new processing. So it's like

Melanie Avalon
I was kind of craving a filet and they don't have a filet, so, oh my goodness. Wait, we should get the prime porterhouse for two. Then we can just like cover the meat section and we'll be like, good.

And a porter, wait, a porterhouse has a filet. What am I thinking? Duh. The strip and a filet. So, but how are we going to get it cooked?

Barry Conrad
See, this is where we might be at odds because you're going to want to blue, blue, blue, blue, and I'm going to want to maybe like medium rare.

Melanie Avalon
medium rare. What if we what if we do like rare plus, which is like in between rare and medium rare.

Barry Conrad
I've never heard that before. Okay, we can do rare plus.

Melanie Avalon
If you feel more comfortable with medium rare, we can do medium rare. That's fine.

Barry Conrad
I can definitely do rare plus for sure, but then I also feel like if we're doing that, I would love to get a different meat as well as a second option in addition like a chicken or a veal situation.

Melanie Avalon
It's a real parmesan.

Barry Conrad
Yeah.

Melanie Avalon
They have a pork chop and peppers, peppers.

Barry Conrad
Oh my God, you know, this place looks really good. I'm

Melanie Avalon
Realizing Italy is definition of nightshades, that's what I'm realizing. It's like peppers, tomato, eggplant.

And to clarify, black pepper is not a nightshade, just pepper peppers, like, you know, peppers.

Barry Conrad
I know what you're saying. You call peppers, we call it, it's not called peppers in Australia, capsicum. We call it capsicum.

Melanie Avalon
Oh, oh, you call like pepper spice capsicum?

Barry Conrad
I think that, is pork chop and peppers, is peppers meant to be like... I'm guessing it's pe-

Melanie Avalon
pepper. So like, okay, so pepper, like pepper singular is like spice. But if it says peppers, that's going to be like, you know, peppers.

Barry Conrad
Yeah, like capsicum.

Melanie Avalon
Oh wait. So capsicum is a pepper pepper. What? I'm like so confused. Okay. So capsicum for you guys is the full thing. Like not the spice. The full thing. Okay. That's helpful.

What is a ribeye Diana? I thought it, I did think I thought it was Diane. They call it Diana, but it's really good. Steak. Diane is pan fried beef steak with a sauce made from the pan juices.

Barry Conrad
Delicious. That looks good.

Melanie Avalon
Okay, so what do we settle on to the Porterhouse rare plus, which is like really annoying to the servers. I'm so sorry in advance and

Barry Conrad
And then we can get the, cause I feel like the robot and Diana, Diana is this, it's still a steak steak. So I feel like we're not going to do the papers.

Cause that's like a nightshade, right? So we're going to do, let's do the veal parmesan.

Melanie Avalon
You can get that it's on the side and this is for you because I got well, I've got the brands, you know We've got the lobster. Oh my goodness

Barry Conrad
we got so much. Can you imagine our table? When we actually finally eat, it's going to be so much food.

Melanie Avalon
Yeah, it's going to be like, we know we probably should do, we probably should just go to somewhere like Texas State Brazil, you know, where you just eat the meat, you know what I'm talking about? Like the Brazilian state houses.

Barry Conrad
Yes, do they have that? Is that a big thing in the states? Because I know it is here.

Melanie Avalon
Mm-hmm. Yeah, Fogo de Ciao, Texas-Dade, Brazil are the two like big chains that do it, but there's a lot of, you know, restaurants that do it.

Just like, actually, I don't know if there's a lot, but it actually, it's like a thing a la carte as well. And I haven't been forever and I kind of want to go to one.

Barry Conrad
I think that would solve our problem of animal protein, like of not having enough.

Melanie Avalon
Yes, let me get this. Okay, do we want a side?

Barry Conrad
Yes. Well, for me, I diff, I would love some potatoes. And then I think that you don't like, do you like broccoli or not? Really?

Melanie Avalon
I mean, I yes, it's spicy, though. And I mean, I mean, if it's, you know, I like it. As my mom would say, I like it, it doesn't like me as much. My mom says that all the time.

Barry Conrad
Like about food, I guess.

Melanie Avalon
Like, I love this, or I like this, it doesn't like me.

Barry Conrad
That's funny. Probably just the potatoes. I reckon that's it. What about you?

Melanie Avalon
You know, I'll pass, we'll eat more meat.

Barry Conrad
Dessert looks good. This place looks so good. I love it What's catching your eye

Melanie Avalon
I'm going to get, so for my dessert, if I liked the clams, you know, we had at the beginning, I'll get another order of clams. I'll probably, though, get like carpaccio or something for dessert.

Barry Conrad
That sounds good.

Melanie Avalon
or like salmon or Dover. No, no, it's bicata, nevermind. Salmon or I will revisit whatever I really liked from before.

Barry Conrad
Mm-hmm. I will definitely get the chocolate raspberry cake as well as the tiramisu.

Melanie Avalon
That's what I was going to guess. I was like, he's either going to, yep, yep, yep, yep. If I were to get one and like have it, but not have it, it would be the carrot cake.

Barry Conrad
Really?

Melanie Avalon
Yeah, do you like carrot cake?

Barry Conrad
I do like carrot cake. I do actually. I would definitely have that.

You know, we played a game last episode about, you know, would that, is it eating window worthy? Carrot cake is eating window worthy for me. I would definitely have that.

Melanie Avalon
but you didn't order it as your two things. So it's not as worthy as chocolate raspberry cake and tiramisu. Which tiramisu I do not like. This is where we diverge. I can't do like the coffee vibe.

Barry Conrad
That's so interesting because you like coffee.

Melanie Avalon
Well, I mean, yes, not in dessert, though.

Barry Conrad
Not to eat it, you don't want to eat your coffee, you want to drink it.

Melanie Avalon
I have never like so like whenever I see like a dessert or any food that has coffee integrated into it no interest it's like conflicting because coffee is like a drink that you have in the morning and like wake up and conquer the day you don't want it in a like a food.

Barry Conrad
That's like an affogato. We've talked about this as well.

Do you remember what that is? No. It's like a affogato. It's like picture like a glass with like a shot of chocolate liqueur over like ice cream. It's really delicious. It's delicious.

Melanie Avalon
No. How about the drinks? I bet they have really good wine here.

Barry Conrad
So I've clicked on the drinks part, not the wine part, and then there's actually wine and cocktails on that list.

Melanie Avalon
Oh, perfect. Okay.

Barry Conrad
I like the font of this place too, it looks, it really gives off a vibe, like this place looks really good.

Melanie Avalon
I know you know what I'm thinking right now, because we're currently trying to finish our design for my glow coffee and I really like the font. I think this might be a good font for our bags.

Barry Conrad
That's good. Is anything, there's a few drinks there.

Melanie Avalon
Okay, so basically their list is so expansive that I feel very confident I can find something. It's going to require, I'm going to have to like research and look them up, see if they're organic, see if they're low alcohol, but I know I can find something definitely by the bottle.

Barry Conrad
Do you know what? I feel like we should do considering what we've just ordered, like thinking about the food options you've just had.

We should definitely get a bottle of white and a bottle of red, and then I'm going to get a cocktail as well.

Melanie Avalon
Perfect.

Barry Conrad
Do you know what I mean?

Melanie Avalon
Yes, I do. So when we go, I will do a lot of research and I will find the perfect bottles that are, are you good with like the organic low alcohol situation with the wines?

Barry Conrad
I'm sure that I'll be good with consuming it, but if I'm being really honest, I have not actively sought out. Let me find out the best. I try to always get the most high quality one, but I'm definitely not as versed as you in the organic go-to's.

Melanie Avalon
So hear me out. I really feel like the organic wines are the most high quality because they are doing the, they're like creating wine the way it's supposed to be created, like from the earth, all natural, exposed to the elements, not spraying it with all these chemical compounds.

So like, it's kind of interesting to me that there are so many wines that are really high priced and yet they do these modern, you know, pesticide situations that just like don't, I don't know, I think if you want like high quality, organic, biodynamic is the way to go, and then preferably lower alcohol if you want to, like, if you're like me.

Barry Conrad
Select what, like 10% or something? Is that?

Melanie Avalon
So I like to cap it at 12.5%.

Barry Conrad
So it's still, yeah, okay.

Melanie Avalon
Ideally, it would be 11.5. Ideally, it would be like in the 11s, 11s or 12s.

Barry Conrad
Interesting, so it's pretty yeah, okay, all right

Melanie Avalon
So like the whole low alcohol wine is not, I'm not talking about like de-alkalized like soup. I'm talking just like not 14% basically or 15%.

Okay. We should get a Pinot Grigio white. That's what we should get. Yeah, definitely. So we will get an organic Pinot Grigio and then we'll find a red and then what will you get for your cocktail?

Barry Conrad
I think because we're at this, I usually like to get a margarita, but I think because in the theme of being in at Cabo and I'm going to get a Manhattan and I have been having a few more of those.

Melanie Avalon
Perfect. Excellent, fine. I love the vibe and you should go and let me know how it is. Okay.

Well, this was so, so amazing. Friends, listeners, we hope you enjoyed traveling with us today. The show notes for today's episode will be at ifpodcast.com slash episode 441. They will have a full transcript as well as links to everything that we talked about. So definitely check that out. If you would like to submit your own questions for the show, you can email questions at ifpodcast.com or you can go to ifpodcast.com and submit questions there. And you can follow us on Instagram. We are ifpodcast. I am Melanie Avalon. Barry is Barry underscore Conrad. Yeah, I think that's all the things. Anything else from you, Barry?

Barry Conrad
No, thank you so much again for tuning in. We really appreciate you. Have an amazing week, and we'll see you next time.

Melanie Avalon
I will talk to you next week.

Barry Conrad
Talk to you next week. Bye.

Melanie Avalon
Thank you so much for listening to the Intermittent Fasting podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed.

If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by podcast doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week!

 


 

 

Sep 22

#440 – Fasting And Biological Age Reduction, DEXA Scans, Measuring Body Fat Percentage, BMI Problems, DNA Tests For What To Eat, CrossFit, And More!

Intermittent Fasting

Welcome to Episode 440 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, biohacker, founder of AvalonX, and author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine, and Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC

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LINKS

Featured Restaurant: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Bubble Room

Episode 412 with Special Guest Dr. Matt Dawson

STUDIES:

Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk

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Original theme composed by Leland Cox, and recomposed by Steve Saunders.


Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.


TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)



Melanie Avalon
Welcome to episode 440 of the Intermittent Fasting podcast. If you want to burn fat, gain energy and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, founder of AvalonX and author of What, When, Wine, Lose Weight and Feel Great with Paleo Style Meals, Intermittent Fasting and Wine, and I'm joined by my co-host, Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC. For more on us, check out MelanieAvalon.com and BarryConradOfficial.com. You can submit questions for the show by emailing questions at iofpodcast.com or by going to iofpodcast.com. We would love to hear from you.

Please remember the thoughts and opinions on this show do not constitute medical advice or treatment. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine. If it's that time and get ready for the Intermittent Fasting Podcast. Hi everybody and welcome. This is episode number 440 of the Intermittent Fasting Podcast. I'm Melanie Avalon. I'm here with Barry Conrad. Barry, how are you today in Australia?

Barry Conrad
I'm good. Hey, Mala. Hi, listeners. Hope you're all doing great.

I am doing well. It's a Sunday morning here in Melbourne, Australia. It's kind of gray, kind of cold, but it's not too bad. Nothing to complain about here. How about you?

Melanie Avalon
Sunday morning in the park. I think it was the 4th of July. Is that the song?

Barry Conrad
Yeah, actually, yeah. Do you want to give us a little?

Melanie Avalon
or Sunday in the park, I knew you were going to say that. I knew you were going to be like, so I purposely Sunday in the park with George then.

Yeah, exactly. Yeah. Awesome. Yay. Is this, so it's kind of fun to be podcasting like back in the old days with you over there, me here.

Barry Conrad
Yeah, it's so funny. Just before we jumped in on the podcast properly, listeners, we were talking about how I was in New York last time we recorded.

So now I'm back in Australia again. So it's like back and forth. But after this stint, after this work trip, I'll be back home, my new home, New York. So we can be in the same time zone.

Melanie Avalon
And for listeners, I did ask Barry if going to New York felt like he was going home and he said no, you know, you said that like going you felt like you were traveling to Australia.

Barry Conrad
Yeah, exactly. Yeah, it feels it's so strange how that can happen. But now coming back here feels like a work trip, which is not bad. It's just different.

Now I'm like, when I go home, a.k.a. NYC, that's a good feeling. I like that.

Melanie Avalon
Well, in honor of you being in Australia and in honor of food, since this is the intermittent fasting podcast, can I rapid fire this article to you? Did I show you the title? I know I saved it for the show, but did I show you the title or do you know what this what it is? It's 11 Australian sweet treats that need to be on your radar. I want to know if this is accurate.

Barry Conrad
Okay, I'm down. I like games. Let's do it.

Melanie Avalon
Okay, so you're gonna rate each one like, does this need to be on our radar? So like, yes or no. And also, what is it? Okay, ready? Number one, Lamingtons.

Barry Conrad
Yes it's kind of living since it's kind of like picture like a square little mini cake with coconut flakes on it it's pretty good.

Melanie Avalon
Literally the picture I'm looking at you describe that really well. You're like a hesitant. Yes

Barry Conrad
Yeah it's like if it's in front of me and it's like my treat day i'll have it but it's not like i'm not gonna go to my way to get it you know.

Melanie Avalon
Okay, so the question I guess is like, is this worthy of your eating window tree day?

Barry Conrad
This is not worthy of my eating window, nah.

Melanie Avalon
Okay, number two. Oh, I know this one. Fairy bread. Yeah. We don't have that here.

Barry Conrad
Really?

Melanie Avalon
No, because it's like so cool. It comes up on things I look at. It's like that cool. But we don't we don't do this. Do you just like to kids like to do kids like eat this?

Barry Conrad
It's like a kid's birthday party situation. Also, Mel, I'm surprised that you don't know this because to me, as soon as you said fairy bread, it made me think of fun, fitty cake.

Is it not kind of the same? No.

Melanie Avalon
It's like a fun fatty cake wannabe because it's literally just for listeners white bread butter and hundreds and thousands oh that's the name of it the australian name for sprinkles what you call you call sprinkles hundreds and thousands.

Barry Conrad
Yeah, don't you? Yeah, of course. That's the only way to call it.

Melanie Avalon
No, I've never heard that in my life.

Barry Conrad
That's so straight. No, that's weird. You guys are saying it the wrong way.

Melanie Avalon
No, hundreds and thousands. It's very like they need to make a choice. Is it hundreds or thousands? It's end.

It can't be. Here's the thing. If it's hundreds, it's not thousands. But if it's thousands, it's hundreds. Think about that for a second.

Barry Conrad
This is not like the one meal a day debate, the hundreds of thousands debate. We're not doing that.

Melanie Avalon
Okay, so fairy red. Eating window worthy?

Barry Conrad
Still a no. I need something. I need something else. What else you got?

Melanie Avalon
Okay, next Pavlova.

Barry Conrad
Yes. Okay, Pavlova. Yeah. I don't know what this is. So it's basically, it's hard to describe this, but it's made with a lot of egg whites. It's sort of like a, you know what a meringue is?

Melanie Avalon
But yeah, that's what this says it is.

Barry Conrad
Yeah, picture like a giant meringue, but also there's a couple layers maybe, put them on top of each other, and then you kind of top it with cream, strawberries.

Melanie Avalon
Does it have a marshmallow-like center? Yes. Oh, this looks good.

Barry Conrad
I know I can make a pretty good one too. I'll have to show you a photo. Yeah, it's delicious and

Melanie Avalon
Okay, wait, next, and Zach Biscuits.

Barry Conrad
Yeah. Anzac biscuits are pretty good. They're pretty, they're an Australian staple.

You know, if you go oatmeal cookies. Yeah. Yeah. Yeah. It's pretty good. Chocolate crackles. I don't think I've tried that. I don't know. That's definitely enough for me.

Melanie Avalon
It's a, it's a childhood birthday party thing. It's like, looks like Rice Krispies with chocolate, hmm? Caramel slice.

Barry Conrad
Oh, yeah. Hell yeah. Caramel slices are the best ever. They're so good.

It's self-explanatory. It's like a picture, like a brownie type consistency, like a square that you get in a bakery, but this is like, has a caramel, like crystallized topping. It's so good.

Melanie Avalon
It looks really good. They say it can be found in almost every bakery in Australia.

Barry Conrad
That's 100% correct, pretty much.

Melanie Avalon
Okay, okay, we're almost there. Oh, this one we've talked about before, Tim Tams.

Barry Conrad
Oh, Melanie, you have to try these, it'll change your life, it's so good. I'm not going to try it.

Melanie Avalon
This is really good. You can only hang out, you can have it.

Barry Conrad
Melanie look at your instagram real quick your messages as a sent you a pavlova that i made.

Melanie Avalon
Oh, okay. Oh, okay. Hold on. This is so exciting.

Barry Conrad
Yeah, from the top, it looks really good. It's really good.

Melanie Avalon
Oh, so does it always have the same type of fruit or can you do like whatever fruit you're feeling?

Barry Conrad
You can have like plain, you could have whatever fruit you're feeling, you could put blueberries on there.

Melanie Avalon
This was your first attempt. Yeah. Okay.

Barry Conrad
But Tim Tams, real quick on the Tim Tams Mel, like when you get Tim Tams, there's a thing, it's like, it's called like the Tim Tams Slam, so this is the scene.

Melanie Avalon
Yeah, I'm literally that's what it says. It says you can participate in Tim Tam slam. What is Tim Tam slam?

Barry Conrad
You basically, you can get your hot chocolate or whatnot, and you put the Tim Tam into the hot chocolate vertically, and then you suck out the hot chocolate through it like a straw and it melts. The Tim Tam melts.

It's so good.

Melanie Avalon
Uh, I think you've told me about this. Yeah, that sounds complicated. It's not.

Barry Conrad
It's not complicated. It's a straw. Actually, you know what, we need to do this and film it and you do it.

Melanie Avalon
Mm-hmm. I'll film it. I'll film it. I'll film you Okay, how about ice bobo

Barry Conrad
I don't know what's that.

Melanie Avalon
The Arnett's Biscuit Company makes ice phobos, golden biscuit with icing, jam, and coconut. You guys like your coconut.

Barry Conrad
And it's a really good brand, so I would have that because they're pretty reliable with their taste palette. It's really good.

Melanie Avalon
Neenish Tarte.

Barry Conrad
Nah.

Melanie Avalon
Vanilla Slice

Barry Conrad
Yes. Yes, yes, yes, yes, yes.

Melanie Avalon
firm vanilla custard sandwiched between two pieces of puff pastry. This looks this looks good. Actually, so thus far, this looks the most alluring to me. Really? Why? Yeah, I love vanilla.

Barry Conrad
Oh, you actually do. I do know that.

Melanie Avalon
It looks like cake. Does it have cake in it? It looks cakey.

Barry Conrad
It has a cake-like consistency.

Melanie Avalon
I like custard. I like cake. I like white. Let's see. Last one. Hedgehog slice.

Barry Conrad
I haven't tried the hedgehog slice.

Melanie Avalon
What a bummer to end on that. It says that it's a prime Aussie snack.

This no baked dessert appeared on the Australian culinary landscape in the 1930s. Where have you been very popularized in the 1970s rumors that it was inspired by 1920s German dessert, but it may have been from England. This is all over the place.

Barry Conrad
I've never seen these in a bakery.

Melanie Avalon
Okay, so we're fact checking you, Tasting Table.

Barry Conrad
I always see vanilla slice, I always see caramel slice, and at nice sort of bakeries, there'll be like a pebble of cake in the little cabinet as well. So those are my top three as well.

So and Tim Tams, of course, you can buy that at the store.

Melanie Avalon
Well, this was epic. I love that.

It's interesting, you know, yeah, none of those. The only one I'd heard of was Tim Tams, I think, because you and I had talked about before, and then fairy bread, because like I said, it comes up on, you know, I just have a love for like rainbow desserts. So it comes up that way. But yeah, oh, I was clarifying why it's not as good as funfetti is it's just bread, and you're hundreds and thousands and and butter, right? But funfetti is like cake with sprinkles on the inside and

Barry Conrad
I still feel like this is an elusive, it's like a mythical thing that just can't, I've never seen funfetti cake in the, in the, in the wild ever, ever.

Melanie Avalon
This is wild to me. You're in New York now, not right now, but you will be. You'll see it, you'll see it.

You could go, you could buy it at the store. Like a, you could Pillsbury, like you could buy a mix, you can make it. Oh please, can you do that? What? Like buy a Pillsbury, funfetti cake mix and make it. They have a gluten-free one too.

Barry Conrad
you know i'm gonna write this down because that's actually an experiment of the willing to participate in to see if it's fun.

Melanie Avalon
Oh, you could, oh my goodness, get both. Oh, see if it's fun and you get the gluten-free and the normal and you could compare and see if the gluten-free is just as good as the normal.

I will like eagerly watch this, like whatever social media content you create from this.

Barry Conrad
Tillsbury mix by it. Okay, cool, I'll put that down as a note.

Melanie Avalon
Perfect. Okay, well, I've been saving that article for like months. So thank you for entertaining me

Barry Conrad
Well, thank you for doing it. Your reaction was so funny at the end, you're like, hedgehog slice. I'm like, I've never had that. Oh, that was disappointing.

Melanie Avalon
And then they go on to say how it comes from like all these other countries. So yeah, poor choice on their part. Well, should we jump into some fasting things? Do you, do you have a study for us?

Barry Conrad
I do have a study for us and the study that I'm bringing today is called fasting-like diet lowers risk factors for disease, reduces biological age in humans, and this is published in Nature Communications in February 2024 by Professor Volta Longo's group.

Melanie Avalon
Valtter Longo represents, he's been on this show, and I think actually I just, God we're talking about this, he just confirmed to come back on either this show or my other show. Awesome, how good is that?

Okay, so this one is about the biological age effects of fasting, a fasting mimicking diet maybe?

Barry Conrad
Yes, it lowers the risk for disease and reduces biological age, which is pretty good, and a topic that we both like. They enrolled just under 100 men and women aged between 18 to 70, and they're all carrying at least one metabolic risk marker.

Everything from elevated fasting glucose to borderline fatty liver rather than full water fasting situation, the participants in the intervention followed a five-day quote-unquote fasting mimicking diet, FMD, once per month for three to four consecutive months. Each FMD cycle provided about 800 to 1,100 calories per day in the form of plant-based soups, bars, and supplements rich in unsaturated fats and low in protein and carbohydrates. Outside of those days, those five days, volunteers ate their regular diet, with half of them assigned to the FMD protocol and the other half maintaining either the usual eating pattern or more of a Mediterranean-style diet. What I find super interesting about this is how – and this is one of the reasons why I love fasting – how seamlessly this fits into a busy life. You don't have to think about every meal or count calories daily. Just commit to a short five-day metabolic tune-up each month. Judging by the 80% adherence rate for this, most of the people found it surprisingly doable, not surprising to us. Complaints were pretty minor, so occasional headaches were fatigued during the fasting days, especially for newer participants. Notice here is adverse events, which really speaks volumes about its practicality. Results-wise, the first up was the metabolic health. The FMD group saw a significant drop in incidence resistance measured by the HOMA and reflected in an average of 0.3 percentage point decrease in HPA1c. So, to put that in perspective for listeners,

Melanie Avalon
That's a lot.

Barry Conrad
It's crazy, so you normally chalk that up, that kind of improvement to months of discipline diet and exercise, and this just emerged after just a handful of five day cycles, which is crazy. They also take a little fat, so non-alcoholic fatty liver disease. It's a silent epidemic, especially in people carrying extra metabolic risks, so MRI quantification showed a 20 to 30% reduction in hepatic steotosis. So among those FMD participants, that was that 20 to 30% reduction. So while the control groups liver fat remains stubbornly unchanged, that's not just like a cosmetic win, it's lowering the risk of progression to type 2 diabetes over time, which is another win.

So there's also the immune system situation. So by analyzing blood cell subpopulations, the researchers observed a massive increase in lymphoid to mellow cell ratio, which is a hallmark of a more youthful immune profile. So essentially FMD pulses the body's autophagy and stem cell renewal pathways. So basically our body clears out all immune cells and then replaces them with fresh recruits, which is exactly what you want if you're gearing up for, like here in Australia, for example, flu season or dealing with chronic stress, which so many people experience.

But the true headline stealer for me email was the epigenetic clock analysis. So using the Levens DNA methylation algorithm, the team showed that the FMD group's biological age fell by an average of 2.5 years. So almost like hitting the rewind button on your cellular calendar, which is pretty crazy. So while the control group saw just a minimal change. So that kind of age reversal is kind of unheard of in like diet studies alone and like suggests like just like profound effects on long term health span.

So for anyone out there like juggling, you know, like demands of work or even like touring, for example, like what I'm doing right now, this approach could offer like a really significant trade off five days a month of modest calorie restriction in a prepackaged, easy to follow format in exchange for sharper metabolism, clearer liver, rejuvenated immunity and a younger epigenetic profile, you know, and yeah, there you have it. It's like it's a human centric low tech blueprint for turning back the clock, boosting resilience and rewind your metabolism all without changing your entire lifestyle. Every single day. And that's the power of eating like medicine, you know, it's like so cheers to feeling younger and healthier. I reckon one month at a time. Mel, what do you reckon?

Melanie Avalon
Awesome, awesome. Well, this is a great find. And I'm excited because I'm looking at this study. So the original study was published in Nature Communications, and it's called Fasting Mimicaine Diet Causes Hepatic and Blood Markers Changes, indicating reduced biological age and disease risk.

And I'm excited because I also see on this study Morgan Levine, who I've had on the Melanie Avalon Biohacking Podcast, and she actually developed a pretty cool algorithm for determining biological age and to just super clarify for listeners. So biological age is this concept that you can measure your true age of your cells and your body rather than your chronological age. So yeah, super cool study that you found, super cool that the fasting mimicking diet, you know, had that intense of an effect. And I'm excited because with the fasting mimicking diet specifically, the commercial version is called Prolon. And it's super cool because it provides a way for people to just like Barry mentioned, when he was reading some of the information about the study, they have these pre packaged kits. So you can just implement this fasting mimicking diet approach, which is basically eating super low calorie, it's all plant based. And you do it for I think, yeah, five days is the cycle. They recently released a new version made with organic ingredients. It's more like whole foods base more sustainable. So I'm really excited about that.

So if listeners want to try that and potentially reduce their biological age and potentially experience the other effects that Barry was talking about, they can go to prolonlife.com slash if podcast. So that's p r o l o n l i f e.com slash if podcast, that will get you 15% off with the code I have podcast. And you also get a $40 bonus gift when you subscribe to their five day nutrition program, if you do that as well. So I think this is cool. I really appreciate the work of Dr. Longo when he's doing with fasting. And I understand that like with Prolon, its intention is to mimic. I mean, that's why mimic mimic is in the word. But its intention is to mimic doing a longer fast rather than like the daily intermittent fasting that we talk about a lot on this show. But it's really cool to see that people can get such really dramatic effects from not that much time investment.

I mean, like you were saying Barry, the HP and C reduction, that wouldn't only take like a 0.3% is a big, big difference there. And then the liver fat and you know, all these other things. So very cool. And the 2.5 it says the 2.5 years was independent of weight loss. So just due to the weight loss. But what they're saying here is people experience that reduced biological age, and it didn't matter, you know, how much weight they lost. So that's cool.

Barry Conrad
So cool.

Melanie Avalon
Very cool. Good find. Well, thank you so much for finding that. Yay for younger biological ages. Shall we jump into some listener questions?

Barry Conrad
Let's do it and the first one we have this week is from Lorena and Lorena on Facebook she asks, can I get my bone density and my percentage of body fat checked without an MD? And a question about those DNA tests, is there one that will tell me whether I would do better on low fat or low carb and that will tell me if I would do better in a cold climate or hot climate?

Melanie, what do you think?

Melanie Avalon
Awesome, Lorena, thank you so much for your question. So this is perfect timing.

I have so many thoughts here about so many things. First of all, and Barry, did I tell you about the Sprint app that I tried?

Barry Conrad
I don't think you did. Tell me. When did you try it? Yeah.

Melanie Avalon
because Lauren is asking about getting your bone density checked and your body fat percentage. Few things here. So bone density, yes, you can get a DEXA scan without an MD. Basically, just Google DEXA scan near me and you should be able to find places near you, hopefully, where you can just purchase a DEXA scan a la carte. That is totally doable.

And then a DEXA scan, it measures your bone density and it also shows your body composition. So your percent of muscle, your percent of fat. So I actually interviewed last week this incredible human being, his name was Jason Moore. And he's developed a lot of technology that has been used in different health related apps. He basically creates AI health technology. Now the way it's manifested is this thing called the Sprint app. And it is, it blew my mind Barry, I think you would absolutely love it. So you download the app and then it uses your phone's camera and you just take two pictures. So one is standing forward towards your phone. It walks you through how to do it. You set your phone on the ground and then you take the picture with your hands up and then you turn and you take one from the side. And it gives you an extremely nuanced report of your body composition comparable to a DEXA scan. So it's so cool. It shows you your exact lean mass percentage, your exact fat mass percentage, your muscle mass percentage. And it's really cool because you can basically be like updating this and testing it all the time. So you don't have to go into a DEXA scan, pay a lot of money. You can just do it from the comfort of your home. And then the app uses a lot of AI to walk you through how to make changes. So if you want to build muscle, if you want to lose fat, like what to do, and then you can actually monitor your progress by doing the scan regularly. It's really cool. It shows also your fat distribution pattern. So whether or not you have more androids fat, which is the unhealthy visceral fat versus the gynoid fat, which is in the hips, thighs, and buttocks. And that's the quote healthy fat. So you get to see your percentage of that. You get to see where you fall and the ratio for that. So like, are you healthy or not with that ratio? I'm just going through it in real time looking at what I have. It's really cool. I will send you the information because you I think would love this so much.

Barry Conrad
I would love this. I want to try it. I wonder if I can use that only when I'm back home, back in New York, or if it's just like anywhere. Probably back in the US, I'm guessing.

Melanie Avalon
I think it's a US app, so I don't know, are you able to download like US apps?

Barry Conrad
Hmm. No, I don't think so. It might not show up. No, I'll wait till I get home.

Melanie Avalon
Okay. I really think you're going to be like a little bit obsessed. It's that cool.

So if listeners would like to check it out, they can get the app in the app store. So again, again, it's called Sprint, S-P-R-E-N. Use the code Melanie Avalon. That will get you a free trial and it will get you 50% off your first month. And so to clarify this, this does not show bone density. So a DEXA scan is also going to show bone density. But if you want to know the body composition, the fat, the muscle, the BMI, literally, this is what you want. I'm really really excited about it. So that can help Lorena. Barry, have you had DEXA scans done or do you measure your body composition?

Barry Conrad
You know what, just as you were talking about this as well, I literally not even getting looked up a place not too far from where I'm staying because I'd like to get a DEXA scan. I'm curious to see, I'm anticipating around maybe 10 to 12% body fat.

I really want to see where it's at. I'm curious.

Melanie Avalon
like what you are. I'll be curious if you get that done and then download the app when you're back in the US and see how it compares.

Because like I said, I was really, really impressed with their like they're validated to be comparable to a DEXA scan for body composition. And I think it's, again, we just know that muscle mass is so, so important. And so this is a way for people to actually see, like this is way better than something like BMI, which tells you, I mean, like calculating your BMI from your just your height and weight is not actually going to tell you your actual, you know, body fat, or muscle, it's just going to tell you your BMI, which, I don't know, I feel like it's not that helpful.

Barry Conrad
I don't think it's awful at all. And I think a lot of the time it almost feels outdated now because someone could have a lot of muscle and weigh significantly more on the scale and then be obese.

But, you know, BMI, which is not really true and not obese. You know what I mean?

Melanie Avalon
Like, yeah, so to that point, so they have a body composition chart and it's four different quadrants and it'll tell you if you're in like low lean mass but not obese, sarcopenic obesity, so obese and low lean mass obese, so high muscle and high fat or high lean mass. So yeah, basically there's four different quadrant options here that are just not reflected in BMI.

Like, BMI is going to tell you one number. It's not going to tell you any of those four things I just said.

Barry Conrad
It sounds really really good. I actually can't wait to try this now.

Melanie Avalon
Yes, it is so, so cool. So that's the DEXA answer.

And then for Lorena's question about the genetic testing, so also good timing because I recently have tried quite a few new genetic tests. So one that I know for sure shows about like the carb fat, macronutrient, like what diet to follow is wild health. So they give you a really, really cool personalized report. And like shows under diet and nutrition, my genetics related to diet and nutrition and it shows me that I, let's see, so like what fat intolerant genes do I have? What carb intolerant genes do I have? What saturated fat intolerant genes do I have? From that they show you what, like what percentage you should be eating. So like it's recommended macros for me are actually well 40% carbs, 35% fat, 25% protein. So kind of like a balanced diet. I clearly don't really follow that. Here are the comments it makes. It says for me, I appear to tolerate saturated fat well and may consume it as desired. I tolerate carbs well and may consume complex carbs as desired. I tolerate fat well and may consume fat as desired. I guess that's why it's recommending kind of like a balanced approach because apparently I tolerate the things. But then I do have, I have a risk associated with, oh, with BCAA concentrations. Really? Yeah. It says a polymorphism that people with this often have higher BCAA levels and thus have less weight loss with high fat, calorie restricted diets. That's interesting. And then I have some risks associated with insulin resistance and diabetes in response to a diet high in fat. But it, oh, so that's actually, so that's where it gets complicated because like, if you look at the risks, like some will be good for fat, but then some are risky for fat. So what I like about wild health is they do, they really like go through and break it down and tell it to you in words that you can understand like what you should actually be doing. Let me see if it does cold tolerance. So they, they have a lot about exercise and recovery recommendations. They have a lot of sleep recommendations or how you tolerate caffeine, mental health recommendations. I don't see anything about hot and cold though, but I, so I do really recommend them. The link for them is wildhealth.com and the code Melanie Avalon will get you 20% off. And I actually had, I had Matt Dawson on this show. We had Matt Dawson on this show and he actually is, so he was actually on episode 412 of this show. So I will put a link to that in the show notes and he is the CEO of wild health. So that's one option for listeners. And then I recently tried a new for me testing and it's called sequencing. So they provided a really intense, like they have so many different reports and it's like pages and pages. And the reports that I have showed more about the, there's a lot for like mental health, things that affect your mental health, how your body tolerates medications related to that.

Melanie Avalon
It shows a lot of your risk factors for different diseases. So things like, I mean, everything from cancer to diabetes, metabolic health, liver disease, all the things. And I was really happy to see that I actually didn't have that many like high risk things. I actually did have a risk for lung scarring, which was interesting, especially because my mom. Really? Yeah, my mom's been struggling with that recently. So I thought it was really interesting that that came up as something on my genetic report and she's been experiencing that. And then I was super high risk for arthritis and osteopenia. And that really runs my family as well. So that was interesting.

But like I said, the reports I got, they focused on the type of exercise to do. So they do have a metabolic health report, but it's more so about your propensity towards different metabolic type diseases. I did not have one about which carbs are fat to eat. But either way, I thought it was really, really fascinating and really helpful. And so the code for that, if listeners would like to get that, they can go to melanieavalon.com slash sequencing. And that link will directly give you 20% off. And you know what, they might have a nutrition report. Maybe I just didn't download it because in my overview of it, it does say they have nutrition reports. So that's definitely a resource to look into. Just the information that it provided was overwhelmingly extensive and so helpful. So I definitely recommend them.

And then I know for sure that self-decode, if you do their platform, they definitely have reports that show you if you tolerate fat or carbs better. That's created by Joe Cohen. I've had him on my other show a few times. He's really, really cool. There's so many customized reports there. So for that, you can go to melanieavalon.com slash get self-decode and use the code melanieavalon for 10% off. But as far as the question about the heat and the cold, I haven't personally in my different DNA tests seen that yet, but I will keep my eye open for it. I'm trying a new one right now called Life DNA, but I don't have my results yet. But there's just so many, there's so many DNA things out there. Barry, have you tried any genetic reports or things like this to show you what you tolerate or what works for you?

Barry Conrad
Yeah, I think we talk about this briefly on another show and I really, when I'm back home, I want to try all the things over there and just get that done and because I'm curious. I mean, I think what's really interesting about what you shared about your, the balanced profile that it gave you about the fat, the carbs and the protein is really, that's a good position to be in that you can tolerate all of them pretty well.

But the protein one made me laugh because you definitely eat more than, what was it, 20% or something?

Melanie Avalon
Yeah, yeah, I encourage people like don't take your genes as the Bible. Basically, you know, there's genetics, then there's epigenetics. So, you know, you can have a genetic tendency towards something, but the environment is so key. And we know that epigenetics, so whether or not your genes are turned on, how your genes are affected by your lifestyle, your diet, your fasting, that can radically change what happens. So I think like, for example, I think even if somebody has a genetic tendency not to tolerate a certain macronutrient, for most people, I would say, if they're eating a really healthy diet, and it's a different macronutrient composition, like you can create a really healthy type environment that maybe you're not like perfectly optimized for it. But if you're happier eating that way, I wouldn't, you know, feel destined by your genes.

And then on top of that, like I gave the example with the wild health report, like it literally said that I can, you know, I do well with that. And then it said that I have some genes that don't help me do well with that. And I've read on other reports that I've had that I, like I've read on other different reports that conflicting things is my point. I still really recommend these reports, because I think they really give you a really cool look into your body and what can be helpful for you just take everything with a grain of salt and it's not destiny. No pun intended. Berry conference shout out. Everybody go see Destiny in Australia.

Barry Conrad
Awesome. Also, Melanie, that's very sweet. Melanie, what you were saying about these tests, how do you typically do it? Do you have to give blood if it's like a kid? How does it work?

Melanie Avalon
That's the thing that I like about this is their saliva test.

Barry Conrad
Oh, perfect. Okay, great. So just swabs, yeah.

Melanie Avalon
If you're schooly-mish at all, every DNA test I've done has been saliva.

Barry Conrad
That's so quick. So just take a swab, mail it back, I guess, and then they, is the turnaround a lot? Is it long?

Melanie Avalon
The actual turnaround is usually really long. I have, I have yet, the good thing is I often get kind of like bumped up in the priority because I'll be like testing the brands to work with them. But yeah, in general, it can take, it can take a while for, cause they have to like run your, they have to like analyze your DNA, which I guess is not a quick process and one thing I really liked about wild, okay.

So what I liked about wild health in particular was how they made a lot of really actionable, practical things. Like I found out I should be taking like a methylated folate and that I should be doing like, I don't know, it just provided really actionable insights. And they also look at your blood work and they, they, they tell you like, Oh, here, based on your blood and your genes, this might be why this is happening. Here's what you should do. I thought that was really cool. Like the combination of the blood work and the genes for sequencing. The thing I think I liked the most was literally saying out of hundreds and hundreds of diseases, what do I have a propensity towards? And then also you can see they go through hundreds of medications and tell you if those medications might be toxic for you. And guess what Barry, guess what was one of the like only medic, quote medications. It said might not be the best for me. What? I don't consider this a medication. Do you want to guess? It's something I really enjoy. It's not alcohol.

Barry Conrad
That's not all Cole.

Melanie Avalon
No, that's not a medication.

Barry Conrad
Magnesium?

Melanie Avalon
No, it's something that they give you when you get procedures.

Barry Conrad
Ah, the gas, like the laughing gas situation.

Melanie Avalon
Yeah, nitrous oxide.

Barry Conrad
Oh my gosh, that's hilarious.

Melanie Avalon
I don't care. I've survived this far.

But isn't that funny? Yeah. And then I got a little bit sad because it made some recommendations for my, what was it that it made this recommendation for? One of the conditions that had the recommendation was to not wear high heels. Really?

Barry Conrad
That's so random and specific.

Melanie Avalon
I was like, this is really sad, but okay.

Barry Conrad
Why? Why would they say? Why did they say that?

Melanie Avalon
Actually, it's on my Instagram, so let me check because I probably should get context for that. Let's see. It was for my arthritis risk.

Barry Conrad
Hmm that you wear high heels like you always wear high heels don't you for going out and stuff?

Melanie Avalon
Yep. And with that, I think it's kind of like a, I don't know, a cost benefit. You have to, okay, it says avoid wearing high heels often. Okay, that's important.

Such as multiple times a week, as this will further increase your risk of knee arthritis. But so I, you know, I go out like once a week, I wear my heels, they make me happy. I think that's anti-inflammatory. So we really got to just take everything. You got to figure out what makes you happy and what's worth the, you know, the cost benefit, in my opinion.

Barry Conrad
And what did you say? I take things to the grain of salt and like, you know, it's, yeah, it's about the bigger picture.

Melanie Avalon
Yeah. Do you know for you, speaking of, I know Lorena's question was about diet, but I mentioned how a lot of these genetic tests look at your, you know, type of exercise that is better for you. Like, do you know if you're more like a strength person versus a cardio person, like from your genetics? I guess you haven't done a genetic test.

So do you know what you think you would be?

Barry Conrad
I think it would be more of a strength person. I mean, I, I have like power, but I do like cardio, just not for long periods of time.

Melanie Avalon
Yeah, same here. And when I got my sequencing back, I'm like very far in the power based sports training and not far not very far away from endurance.

So as I'm more likely to excel in sports requiring physical power and strength, less likely endurance.

Barry Conrad
Next thing listeners, Mal, you'll see her on her Instagram. I'm doing a crossfit class. You're doing like, you know, these competitions. That'd be so funny and not surprising if you do.

Melanie Avalon
I don't think that's in the cards for me. Have you done CrossFit?

Barry Conrad
I have done CrossFit. I floated with CrossFit for a little while actually a few years ago, but the reason why I stopped was because you're just too prone to injury. And I actually injured myself a couple of times and it's really explosive movement. And if you're not properly trained or coached, then you're going to hurt yourself. So it's like, I can't sustain this kind of training week in and week out.

So yeah, let me pivot.

Melanie Avalon
Yeah, I think that's smart. You have to really be super aware. I think a lot of people don't focus on injury prevention, recovery, all these things, and it's so, so important. So kudos to you for listening to your body.

Barry Conrad
Sorry to interrupt, one of the first things that I did with CrossFit was like a kettlebell. Do you know what a kettlebell is?

Melanie Avalon
Mm-hmm. I speak I speak that

Barry Conrad
a kettlebell, maybe it was called something different in Atlanta, just like the hundreds and thousands.

Melanie Avalon
just Atlanta, it's called something different. Here we call it a kettle. I don't know, I was gonna make a joke and nothing's coming to me.

Barry Conrad
One of the first things I did for CrossFit was a kettlebell swing challenge and no one had walked me through the form so I was just like going for gold and swinging and there was like a coach standing right next to me and I was like bro you could have told me to watch my form and basically after that I was out for two weeks and my back was jacked in the worst way.

Melanie Avalon
Yikes to be. Yeah, this is why I just go to Msculpt.

Barry Conrad
Or you lay there and then it goes duh-duh-duh-duh-duh-duh-duh-duh-duh-duh-duh-duh.

Melanie Avalon
I just lay there and I let it do the right form and yeah.

Barry Conrad
Oh my gosh. And you're probably doing emails, right? At the same time, like you're doing something multitasking.

Melanie Avalon
Well, I can't, I can't, when I'm doing my arms, I can't use my hands. So I normally do work calls during it.

I schedule calls during M sculpt. And then I have to apologize at the beginning. I'm like, if you hear a weird sound in the background, that sounds like cicadas. It's yeah, it's the machine.

Barry Conrad
Is your voice going like that like to people go how can you.

Melanie Avalon
No, but there's like this, but it makes this like really loud. It literally sounds like cicadas, like sound in the background.

Do you know what cicadas are? Do they have that in Australia? What's that? Oh, man. So like that, like, okay, wait, in Australia, do they have like, when you go out in the, that night, that like, that crickety, that loud cricket, screaming cricket sound, but not cricket? Yeah. That's a cicada. There we go. Yeah. So, all right. Well, thank you, Lorena, for your question. Well, very, shall we have our proverbial raking of the fast moment?

Barry Conrad
I'm so ready for it, let's do it.

Melanie Avalon
Okay. Oh, this is me. Okay. So let me pull up the restaurant.

Barry Conrad
It's been a minute, so I can't wait to actually see what you've chosen. Like if you go on Disney routes, if you go on a different route, if you go on, I don't know.

Melanie Avalon
Okay, the reason I chose this restaurant is in Disney. My favorite restaurant actually, I don't know if it was my favorite, top three restaurants, it actually wasn't in the parks. It was at the Swan and Dolphin, it was at the Dolphin Hotel. And actually it was a chain restaurant, but I just had so many good memories surrounding it and it was called Shula's.

It is now gone. And as of this recording, which will be in the past, but it just reopened this week as a new restaurant.

Barry Conrad
Win. That's awesome.

Melanie Avalon
Yeah, it's like brand new. It's from a Michelin-starred chef. It actually, I think what I read was previews. So it's not actually open yet.

So I don't know if we can look at the menu. What? I might have to pick a different one.

Barry Conrad
So, but it is reopening, which is exciting. That's good, right?

Melanie Avalon
Yes, it is reopening. So actually, I have to pick a different one because it's just in previews right now, so we can't look at the menu.

Barry Conrad
That's so exciting for you because it's your one of your faves is going to be coming back.

Melanie Avalon
Yes, yes, yes. Okay, so I will, I'll just rapid fire pick a different one in Disney. Okay, so since I can't do that new restaurant yet, I guess I'll have to do it next time.

We're gonna go kind of close to there, not really, but Sanibel Island is where I used to go there every summer growing up and my parents have a condo there now. And there are so many incredible, cool restaurants. And one of the most fanciful vibe of a restaurant, it's actually on Capitiva Island, which is connected to Sanibel. It's called The Bubble Room. I'm sending you the link, Berry. It's so whimsical. It's like an emporium of Christmas lights and Coca-Cola memorabilia and Disney stuff and Christmas stuff. It's chaotic. If clutter bothers you, don't go here. I don't know if there are pictures online. Do you see, let's see. It's just like souvenirs everywhere and really weird things. It's a vibe.

Barry Conrad
It's very Disney-esque because I totally get why you picked this based on the aesthetic.

Melanie Avalon
It's really cool. It's just like being immersed in like Willy Wonka Wonderland-ness. And they have an incredible, you'll like the dessert list. They have tons of like cakes that are insane.

But let us look at the food. Dinner menu. Dinner menu. Okay. So I'm just getting so nostalgic. I want to go there right now. It's so cute. Do you see any appetizers that you would like?

Barry Conrad
I actually do what's jumping out at me straight away, which doesn't maybe is not exciting to people, but I love any kind of seafood or clam soup or anything like that crab soup. So the shi crab soup, I'm definitely going to get that as well as the, ah, the flaming soccer cheese.

That looks pretty interesting. Caseri cheese, flamed with brandy, served with bread and, ah, you can't tune a piano. Oh, that's hilarious. Dad joke tuna. It's this is, it's felt like you can't, and then T U N a to the, you know, actually I'm definitely getting those, those three you can't tune a piano. Yeah. What about you?

Melanie Avalon
Solid choices. I think I would get I would appreciate the cheese through you I would also like that.

I would like the tuna tartare. Yeah Definitely the you can't tuna piano you we have to get that that's like that's like Barry Conrad right there

Barry Conrad
That's hilarious. You got to, I don't know why that's so funny.

Melanie Avalon
And then, okay, for your actual meal. Okay, here we go. And keep in mind you're like in an eye. Oh wait, Barry, have you been to Florida?

Barry Conrad
Yes, I have. A few times.

Melanie Avalon
Okay, have you been to like the keys or like the golf? Have you been to the golf?

Barry Conrad
I have not.

Melanie Avalon
So this is like an island in the Gulf. So it's a different vibe than the Atlantic ocean. It's like warm and I don't know. It's warm on the other side too, but I don't know. It's a different vibe, like the Gulf vibe.

So what would you like for your entree?

Barry Conrad
This looks really good. There's a few good choices here. I'm like, what am I going to choose? I think I'm going to go for, uh, I've got to go for this.

It's the some like it hot, hot, hot, which is shrimp and tequila, hot butter with rice. No, no, no. I'm scrapping that cause I don't love beans. I'm going to go to captain's courageous, which is salmon and coconut, coconut shrimp with rice and chili sauce. Let's go.

Melanie Avalon
Nice. That's a really solid choice, especially like where you are. I feel like that respects the island.

Well, I kind of just because it's called Marilyn Mignon instead of Marilyn Monroe, which by the way, there's also like Marilyn Monroe stuff everywhere. Like I can't, I'm not describing this place well, but just look up Bubble Room Captiva. Well, I think, okay, so maybe the Marilyn Mignon, which is a filet mignon wrapped in bacon. Oh, over demi-glace with onions, but I would get it without the sauce. Although I think I would ask what the fish of the day is. And if it's something low mercury, I might get that too. I might get both. Yeah. Yeah. And so that's called smoke gets in your eyes.

Barry Conrad
I like these names, they're so good.

Melanie Avalon
Yeah, yeah, that's what I'm, that's what I'm feeling.

Barry Conrad
Good choice. I'm also gonna I have to add another mains to my mother another main meal.

It's going to be the pork chops. It's the Charlie Chaplin chops. Good name pork chops with bourbon mango or mushroom at Merlot sauce. I'm going to do the mushroom.

Melanie Avalon
I was wanting the pork chop too. So that makes me happy.

Haven't you eat a lot of pork Mel? Oh, not really. I love pork. Yeah. Every now and then I'll get like a really intense craving for it and I'll like have to have pork. I don't know what, what nutrient is in it that I'm craving.

Barry Conrad
Yeah. I don't know if it's an American thing or not, but in New Zealand and in Australia and South Africa, when we have pork chops, we like to have it with like mustard. You do that too?

Melanie Avalon
No. I mean, like, I mean, I mean, it might be a thing, but it's not like a thing thing, you know, it's not like, it's not like you're like pork chop, oh, mustard, like Dijon mustard, creole mustard, I went through a mustard phase, and I even like made it myself, it like almost blinded me, or is that the horseradish?

Like, I remember I think it was horseradish. Have you ever, I'm trying to think it was the mustard that I chopped up or the horseradish that I chopped up and they say like, don't look into it. Oh my goodness, don't look into it. You will go blind.

Barry Conrad
Like, audience sort of thing, but worse.

Melanie Avalon
Yeah, no, yeah, like sear your eyes out like I think it was the horseradish.

Barry Conrad
Did it taste? Do you feel like yours tasted good, the one that you made?

Melanie Avalon
uh-huh yeah yeah you should try it it's like really approachable like you know you just go get some horseradish at the store and then like chop it up but don't look inside

Barry Conrad
So you just want to have like the top and then have.

Melanie Avalon
You got to let it air out. You like cut it into squares and you put it into a chopper and then you like let it sit and you don't look at it.

Okay, and then we get to, I guess we're gonna, are we skipping from the garden?

Barry Conrad
Yeah, I don't need the garden. I'm not doing that.

Melanie Avalon
Yeah, these are the desserts that they're massive and the pieces are huge and I'm getting so many flashbacks right now And I'm getting really nostalgic and emotional. It's fine

Barry Conrad
Oh my god this smell you know me and there's so many things right now that making me excited looking at this dessert menu.

Melanie Avalon
Am I guessing for you?

Barry Conrad
Sure. There's a, there's definitely two minimum for me that I immediately would.

Melanie Avalon
Well, do you want the French chocolate, Tort?

Barry Conrad
Yeah, yeah, we'd have that.

Melanie Avalon
Was that one of two or you would have? It wasn't one of the two though.

Barry Conrad
Was it wasn't one of the two but don't if you're gonna say it wasn't

Melanie Avalon
I didn't think it was, I, yeah. I knew you wanted, okay, wait, is it the butter crunch ice cream pie? Oh wait, very moist chocolate cake, I missed that. I missed, okay, I thought there was only one chocolate.

I'm taking my answer back, I'm starting over. Very moist chocolate cake.

Barry Conrad
Yes, but I kind of cringed when you said that because I'm not going to say the word, but that second word in that sentence, I hate that word so much.

Melanie Avalon
You're one of the triggered people. You can't do the word moist. Moist? No! Don't say it! Why does it bother people? I don't understand. It doesn't bother me.

Barry Conrad
I said it to my mom, I said, mom, I don't like it. She goes, I said, well, I said, there's so many different ways to describe a cake like

Melanie Avalon
But it's moist. Do you see the picture of it? Do you see the picture? If you click through the pictures, look how good it looks.

Barry Conrad
It looks so good. Melanie, I want that right now.

Melanie Avalon
Oh, it's so good. And the red velvet cake is to die for.

Last time I went there was back in my cake eating days. And I think actually, wait, true story, like confession moment, I am obsessed with red velvet. And I think it's very emotional for me. And I think it ties back to having it here. Like the first time I think I had red velvet cake was at this restaurant.

Barry Conrad
This is a moment, I actually would, I'm obsessed with Bella cake and chocolate cake, so both of those. Oh really? Yeah, both of them, yeah.

Melanie Avalon
That was your other one that you would get? Well, that's perfect, too perfect because the very moist chocolate cake is probably your best cake.

Why would you say that to me? With the red velvet. So even hearing it bothers you? Yeah.

Barry Conrad
It's like hearing and seeing it. I just I can't deal especially here

Melanie Avalon
It's funny is that that's very common, you know, like a lot of people feel that way. Really? Yeah. Oh, you didn't know this

Barry Conrad
Well, I thought people like try to make it seem like Barry. Why? What's the deal? It's just a word.

Melanie Avalon
I'm validating you right now. No, no, no, this is like, no, no, no, no, no, no. This is like a thing. People do not like that word.

So like you'll read reviews of restaurants and they'll like not say it. They'll be like, they'll like make it like a curse word. They'll be like, M you know, asterisk. Really? Yes. This is a thing. This is like, you are, you are not alone. Don't listen to the people who say that you're alone because you're not, you're not alone.

Barry Conrad
It's kind of it's it's kind of like nails on a chalkboard or like what's another sound like when people write do you say Sharpies in America like you know when you write on you know there's like sharpies I hate that the sound of that and I hate the sound nails of chocolate.

Melanie Avalon
Oh, really? Yeah, I can't do it. There are some things I hate the sounds of, but neither of those bother me. There's something that really bothers me and I'm trying to think what it is.

Oh, I don't like, I don't like, this might be more a texture thing, I don't like Kleenex rubbing together. Kleenex? It's very specific. I know, I can't really quite explain the situation that I don't like, but it involves Kleenex.

Barry Conrad
I've never heard that one before.

Melanie Avalon
And when i think of something else i'll let you all be like this really bothers me.

Barry Conrad
Yeah, but I'm literally I'm having a physical reaction thinking about sharpies on a book like I'm literally like physically something's happening thinking about it.

Melanie Avalon
Wait, oh wait, you're talking you're not talking about sharpies. You're talking about dry erase boards

Barry Conrad
Yeah, you know, it's like there's a like, like a pen on a whiteboard, you know, and you can wipe the board off like

Melanie Avalon
So this is going to be helpful to know. This is helpful for you to know because Sharpies here, well, oh, wait, does Sharpies, they make dry erase.

So when we say Sharpies here, we think of like Sharpies that you use on paper.

Barry Conrad
Oh, that too. Oh, I can hear it right now. It's crazy. It's so visceral.

Melanie Avalon
Oh, I love that sound. It makes me happy. It reminds me of being back when I was little my dad's office and like getting all the markers and writing on the whiteboard and feeling really like cool.

Barry Conrad
This is good because maybe I should use, I can use this for like a scene that I meant to feel just in agony.

Melanie Avalon
What you could, you could, like the response it's going to make in your body is going to be so authentic. They're going to be like, cast him, you'd be like, what, like, what did it for you? They'll be like, well, you know, when you just had that visceral response of like complete anxiety and displeasure, we knew, we knew it was you.

Barry Conrad
That's so funny.

Melanie Avalon
And then the wine list, I feel like I got to bring in, well, is there a cocktail that you want?

Barry Conrad
No for sure you already know me i'm gonna go for i'm trying to find my eyes is trying to find a tequila based one here i will golden age of hollywood. Give a golden tequila grandma and lime upgrade to an a list with the trans silver and control do that as well sounds good i'll have a cocktail.

Melanie Avalon
Amazing. And I will, I'll bring a bottle of dry farm wines.

I'm looking at the wine list, and it's a little bit like US conventional. So I have been to the one of those wineries though. Two of those wineries. Two of those wineries. Yep. Behringer and Francis Coppola, which is a very stuff from the Godfather there.

Barry Conrad
That's so cool. Are there any wineries in New York State that you know of that I should check out?

Melanie Avalon
Oh, I actually, I don't know, I'm sure there are. You should add that to your to-do list. That'd be...

Barry Conrad
What about ATL? Any around there?

Melanie Avalon
Yes, there's quite a few like North Georgia, North Georgia wineries. And they're so cute. And like very beautiful. So when you come, we can go.

There's one place called the chat. Oh, I'm gonna save that for a restaurant. Never mind. Save it, save it, save it. Okay. Well, in any case, listeners, friends, thank you for being with us on this in the spirit of the bubble room restaurant whimsical journey through life, dancing through life. The show notes for today's episode will be at iapodcast.com slash episode 440. They will have a full transcript. They will have so many links to the things we talked about because I was taking so many notes with so many links. So all the codes, all the discounts, everything will be there. If you would like to submit your own questions, you can directly email questions at iapodcast.com or you can go to iapodcast.com and submit questions there. And you can follow us on Instagram. We are iapodcast. I'm Melanie Avalon. Barry is Barry underscore Conrad. I think that's all the things. Anything from you Barry before we go?

Barry Conrad
That's all the things. Thank you so much for tuning in once again everyone. Have an amazing week and we'll catch you next time. See you all!

Melanie Avalon
I will talk to you next week. Bye.

Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes.

We couldn't do this without our amazing team. Editing by podcast doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

See you next week!


 

 

Sep 15

#439 – High Protein Processed Foods – Good Or Bad, Social Problems With Fasting, Fasting Inconsistency, Protein Leverage Hypothesis, US Food Options, Protein Metabolism Benefits, Hunger Hormones, Ultra Processed Foods Problems, And More!

Intermittent Fasting

Welcome to Episode 439 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, biohacker, founder of AvalonX, and author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine, and Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC

SHOW NOTES


SPONSORS & DISCOUNTS


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LINKS

Featured Restaurant: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Canoe

https://www.instagram.com/p/CnH-86tua07/?igsh=N2NiaTdxbnc5ZzAx

Book: The Longevity Leap: A Guide to Slowing Down Biological Aging and Adding Healthy Years to Your Life

STUDIES:

Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts!

Original theme composed by Leland Cox, and recomposed by Steve Saunders.


Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.


TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)



Melanie Avalon
Welcome to episode 439 of the Intermittent Fasting podcast. If you want to burn fat, gain energy and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, founder of AvalonX and author of What, Win, Wine. Lose weight and feel great with paleo style meals, intermittent fasting and wine. And I'm joined by my co-hosts, Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC. For more on us, check out MelanieAvalon.com and BarryConradOfficial.com. You can submit questions for the show by emailing questions at iapodcast.com or by going to iapodcast.com. We would love to hear from you.

Please remember the thoughts and opinions on this show do not constitute medical advice or treatment. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time and get ready for the Intermittent Fasting podcast. Hi everybody and welcome. This is episode number 439 of the Intermittent Fasting podcast. I'm Melanie Avalon. I'm here with Barry Conrad. Barry, how are you today?

Barry Conrad
Hey, Mel. Hey, everyone. I am doing so good today.

Melanie, on the weekend, I actually went to a Studio 54 themed birthday party. It was like a joint birthday for some new friends, and I reckon you would've loved it. It was like 70s, 80s kind of vibe. Yeah, it was so much fun. I've never been to one of those before, Studio 54.

Melanie Avalon
What do you think? I think that's it for now. Bye.

Barry Conrad
I wore this like white, sort of like a white cream polo with navy trimming orange pants, like orange trousers. These white kicks and I combed my hair out like Afro style.

So like Jackson 5 kind of vibes.

Melanie Avalon
Yeah.

Barry Conrad
Yeah, it was so much fun.

Melanie Avalon
Because Studio 54 is 80s, right?

Barry Conrad
mid-70s through to 80s. And I thought of you that night because some of the girls were wearing all these sparkly things and one of the girls said, I'm wearing all the sparkles of like, oh, this is such a Melanie thing.

She'd love this.

Melanie Avalon
We would have been friends. It's amazing.

Barry Conrad
Have you ever been to one of those?

Melanie Avalon
No, but the closest thing is not last biohacking conference, but biohacking conference before that. The theme was 80s.

And I was like, I can't, like the 80s is so disguised, I just, there's nothing redeeming about the 80s in fashion and clothing. And then I, that's when I found Studio 54, I was like, oh, I can kind of do that vibe rather than like 80s.

Barry Conrad
What about the 80s do you not, you know, feeling the big.

Melanie Avalon
hair.

Barry Conrad
You don't like that?

Melanie Avalon
No the clothing like 60s you can make you 50s you can make use 70s you can make you 80s is rough

Barry Conrad
It's like rockstar vibes.

Melanie Avalon
Yeah, I guess if I can just wear a lot of glitter, it's kind of like 80s and then like 90s shoulder pads like who I hope that I bet that trend won't come back because I feel like that was one trend that was about like feminism and stuff.

What's that one? Like the shoulder pads and for women in the 90s.

Barry Conrad
I still see shoulder pads in some fashion stuff like really definitely

Melanie Avalon
I get ya. I just, I feel like it's contrary to the way the feminine form is natural, like I don't, I just don't understand it.

Barry Conrad
So it's a note for you to wear shoulder pads and to your next show that you go to.

Melanie Avalon
Yeah, I just I don't want to look like a man. That's not my style.

Barry Conrad
your vibe, going for it.

Melanie Avalon
No, I'm all about the equal rights and working like a man, but I don't want shoulder pads.

Barry Conrad
What about you? How's your week been? How's your weekend?

Melanie Avalon
It's good. I'm excited because I'm looking ahead at when this airs.

So this airs September 15th. Do you know what I will have done a couple of days ago? What? I will have gone to Hans Zimmer concert front row. Really? Yes. Have you seen him live?

Barry Conrad
I sadly have not yet and that would be absolutely incredible, that would be amazing.

Melanie Avalon
I was looking at clips of like the potential lineup from past concerts and it's like, you know, like Pirates of the Caribbean and Lion King and all and like Inception and all these like really epic songs.

Barry Conrad
That would be amazing. Who are you going with?

Melanie Avalon
to be determined. Do you want to come?

Barry Conrad
TVC. Actually, because this is, I just realized this is...

Melanie Avalon
Oh my goodness, because you actually could have come, but you won't be here.

Barry Conrad
Yeah, I'll be wrapping up destiny in Australia, back in Australia, which is so wild to say.

Melanie Avalon
wild. Yeah, when is the last when's the last show?

Barry Conrad
like mid September. So exactly when you're watching Hans, I'll be maybe doing the curtain call.

Melanie Avalon
Whoa, wild. That's crazy.

I was watching actually this week. I was our people who make the show notes needed the link to your like to Destiny for tickets. So I was looking at the website and I was watching the video they have on there of you and your your co star, like talking about and stuff. It was really cool.

Maybe we want to go see it. I mean, I already wanted to see it. But I was like, I want to go.

Barry Conrad
I can't wait. You should come. You should come, but I know that it's, I think it's just a bit too far for Melanie to travel. And also, you'd have to be there for more than a day, so.

Melanie Avalon
yeah it's like oh it's a little far Yes, definitely. Someday, though.

Barry Conrad
I also saw a movie that I think that you I think you might like when I was watching it with this movie club

Melanie Avalon
What movie?

Barry Conrad
It's called the materialists. Have you heard of it?

Melanie Avalon
No. Is it new?

Barry Conrad
It's new. It stars Dakota Johnson, Pedro Pascal, and Chris Evans, and it's about dating. It's all about, like, she plays this matchmaker, a professional matchmaker. And it's basically revolves around this matchmaker who treats dating like a spreadsheet, like money, height, image, you're either in or you're out. I reckon you find it really interesting.

I didn't love the movie, but it did make me realize in a weird way how we can sometimes approach health that way. Like we want sometimes one shortcuts or hacks or perfect macros. But forget that the real transformation, whether in love or fasting, whatever, is isn't just about numbers. It's about showing up with consistency and tuning into what feels right and not just outsourcing, you know, just data. Do you know what I mean?

Melanie Avalon
That was such a beautiful segue and like, in comparison, I feel like you were made to be a motivational speaker.

Barry Conrad
What do you mean? I'm not motivational.

Melanie Avalon
I mean, that was really motivational, what you just said. I'm like, yes, sign me up.

Barry Conrad
But thank you. That's very kind. And also, I do think you should check it out because I think you'd find it entertaining. It's pretty funny.

Melanie Avalon
Is it in theaters right now?

Barry Conrad
It's in theaters right now, and it's savage as well, just that, you know, it's like really savage.

Melanie Avalon
Oh, how do you define savage? I feel like I don't use that word a lot.

Barry Conrad
sort of just really brutal, like really crazy what she says and what the people go to asking for like, this is what I want. This is what I don't want.

And it's stuff that things that you wouldn't say to people necessarily, but you're paying someone to set you up with someone. So you're saying all these really crazy things. You shouldn't. I think you'd like it. Let me know what you think.

Melanie Avalon
I like Dakota Johnson. A lot.

Barry Conrad
I don't know why I think that you would, but I thought that as soon as I was sitting there, I was like, I reckon Mel likes her. I don't know why.

Melanie Avalon
Did you, did you back in the day, read Fifty Shades of Grey? I feel like that, because that's kind of what, it's not kind of what like, made her pretty famous.

Barry Conrad
I didn't watch any of those movies, see that's not for me, I don't love those kind of romance novel things. It's just too much for me, erotica.

Melanie Avalon
The thing about it was, you know, because it came out after it was like all based on Twilight. Like that's, do you remember like the book? Really? Yeah, it was fan.

It was Twilight fan fiction. I know it's not the Twilight characters, but that's what inspired it. So and I was a big Twilight person. And then it was like a whole thing. People were like reading in. I read the first book. I was like, okay.

Barry Conrad
Did you watch all of the shades of grey ones, you know?

Melanie Avalon
So why did I do this? I saw the movie when it came out, the first one, and then I don't think I saw the others. And then like a, hmm, like a year ago, year and a half ago, two years ago, maybe two years probably, I was like, I kind of I'm gonna watch the Fifty Shades of Grey trilogy, like, I'm just gonna do that right now. And I did.

I don't know why. Yeah, it was fun. It's like, when you make it through, you know, watch it, when you watch like all three in a row, then you make it to the end. And they do like the really sentimental like montage, flashback of like the scenes in the beginning. And you're like, I'm getting emotional. And you're like, what is this? Like, this is not what am I doing with my life right now?

Barry Conrad
I feel like it's a female thing, I don't know.

Melanie Avalon
I think it is. Did we talk about this? How I met somebody who actually has

Barry Conrad
Also, let me zoom out for a second and say, I'm sure it's for everyone. It's just like more and more experience. It's not something a lot of guys I know watch those movies.

Melanie Avalon
No, I completely understand what you're saying. I think it is.

I mean, it was really... And like, the book was like a whole... Women read it a lot more. Have I discussed or have we talked about Fantasia? No. Okay, there's a reason I'm saying this because we're talking about reading books.

There's this thing called Aphantasia and it's where... Okay, so you know when like, you're reading a book and you picture it in your head? Like, the story?

Barry Conrad
All the time.

Melanie Avalon
Yeah, some people can't do that. What do you mean, you can't do that? It's called aphantasia and they don't, they literally can't make mental images in their head. It's like being blind in your mind.

So like if they're, and so then the reason I'm talking about it is I made a new friend and we were talking about like, cause he seemed like the reader type, like not that there's like a reader type, but I was saying how I used to read a lot growing up. I'm like, I bet you did too. He was like, actually, no, not really, but there's a reason for it. And then he said that he had aphantasia and I was like, Oh my goodness. Cause I had just, I had just read about it. So he can't, I was so excited. I felt like it was me as a celebrity. I was like, you have this condition, tell me more. So like you, when you have it, you can't, you can't make mental images. So he was saying like, he was never really intrigued by reading because you can't, you don't picture it in your head. You just read the facts.

Barry Conrad
That's really sad to me because the whole thing about reading for me, especially fiction, is the mental imagery that it evokes.

Melanie Avalon
Yeah, isn't that crazy?

Barry Conrad
That's really crazy. And at first, how's that possible though? How can you not imagine?

Melanie Avalon
I don't know. But then the thing is, the crazy thing is they can't imagine what it would be like to do that. Like to them, it makes no sense.

Barry Conrad
So can they imagine anything even if they're not reading like just imagine the summer's day or that they can't picture make any pic for many pictures.

Melanie Avalon
Yeah, no, no, they can't see anything in their head. Wow. Yeah, I was reading out because I went down the rabbit hole because I learned about this for the mind blown podcast. And then I was going down the Reddit rabbit holes, reading like things from people who had it.

And like one person was saying she was a painter. And the reason she liked being a painter was because it allowed her to actually create in the world what she couldn't see in her mind. I was like, Oh, wow, that's really deep. You know,

Barry Conrad
Yes. Aphantasia. Aphantasia. It's kind of like a very pretty name for a bad situation.

Melanie Avalon
I know, right? But I wish you could have seen me because I've known about it for a few months now. And then when I met the guy who had it, I literally freaked out. I was so excited.

I was like, I have so many questions for you. And some people don't realize they have it, like, because they don't, they don't know that you're supposed to, you know, it's like a thing like, it's hard, it's hard to notice the absence of something.

Barry Conrad
Yeah, I really love, I love the power of imagination. It's such an important part of being creative.

Melanie Avalon
Yeah. Yeah. And I mean, they can imagine, you know, situations, but they can't see, they just can't see any of it.

Barry Conrad
Wow.

Melanie Avalon
So yeah, reading would be so boring.

Barry Conrad
Yes, just data and numbers and letters.

Melanie Avalon
Yeah.

Barry Conrad
It's not for me.

Melanie Avalon
Me neither. Glad we don't have that.

Barry Conrad
It should be like, I don't know, it's not, not anyway.

Melanie Avalon
not something so pretty. Yeah. I feel like actually that the word for when you don't have feelings is also very pretty. I think it's anhedonia.

Barry Conrad
Yeah, that sounds like someone's name, like a girl's name or something.

Melanie Avalon
Anhedonia. So, so beautiful sounding, but it's the inability to experience joy or pleasure. What?

Barry Conrad
That's sad.

Melanie Avalon
Yeah, it's a common symptom of depression, but it's not actually depression itself. It's just literally not having, it's like feeling numb.

Barry Conrad
Aw, man.

Melanie Avalon
So anhedonia and

Barry Conrad
Aphantasia.

Melanie Avalon
Fantasia. I think of Anastasia. Anastasia.

Barry Conrad
I mean, I'm surprised to hear that. And speaking of surprises, Mel, I know that you mentioned something about you don't like surprise parties. Why is that?

Melanie Avalon
Oh, yes, just really quickly. Yeah, because because Barry was telling me about a surprise party situation, as he would say in his, in his words, and I was like, I can't believe we haven't talked about this. So basically, don't throw me a surprise party.

Okay. But why? Because I need to. There's a way that you can if you really want to, if you really want to, I have to think that I'm going to something like I want to like, look my best and like be prepared and like, so I need to think I'm going to something else where I'm already dressing up, then it can be a surprise party, I guess.

Barry Conrad
So basically, if there's a dress code or like the style of event, then you can work with that.

Melanie Avalon
Yes, like because I want to make sure that I'm in like the right party mode, you know, and I've like done the party thing. That's the other thing, like my schedule, like I need to be in the in the right energy, which means I need to prepare for it.

So I need to think that I'm going to something else. If you don't, what happens? I'll be not happy about the situation.

Barry Conrad
Is this kind of like that fought restaurant situation?

Melanie Avalon
Yeah, my mom knows this she's like I never threw you a surprise party because I know that you were not Although I did get thrown a surprise party once true story When I graduated early from high school my all my friends threw me a going away party a surprise party. I'm actually trying to remember Because you know what?

I remember. Um, oh, I know what happened I thought I was going over to like spend the night with my friend This is before I was crazy. I guess I was fine. I guess I was better with surprise parties back then I thought I was going over to spend the night I was so exhausted because they threw it like right after exams I remember talking about I was like i'm not gonna go i'm i'm too tired And she was like you have to go. I was like, no, I don't I was like, why do I have to go? She's like and then she and then she told me she was like I wasn't supposed to tell you but they're throwing a surprise birthday party or a surprise party So then I have to go

Barry Conrad
Do you think that you could ever revert back to liking them or not? Or would you ever like them and...

Melanie Avalon
I think I would like it if we follow the protocol I just gave.

Barry Conrad
like sans protocol if you were like so what if people turned up to your door like a massive surprise like all these people

Melanie Avalon
No, don't I don't want people coming into my my life.

Barry Conrad
Like if they basically like you just got back from choir therapy and all of a sudden you get this knock and the open the door and these balloons and everything and

Melanie Avalon
Don't do that.

Barry Conrad
Or would you just leave them outside like you can't come in?

Melanie Avalon
I'd be like, I'd be like, thank you guys. Can we do this another time? Can we, I'll meet you tomorrow night? Yeah, how about you? Are you down for any surprise party anytime?

Barry Conrad
You know what? I actually get shy at stuff like that because I'm fine with being on stage, being on camera, doing a podcast, anything like that. But when it comes to life, when it comes to attention put on me in personal situations like that, I get kind of bashful and shy.

I'm grateful, but I don't get mad. I just get shy, really shy.

Melanie Avalon
No way, in all social situations or just like this type.

Barry Conrad
Well, not also, no, I could like, you know, in life, I can hang out with anyone and stuff, but I think with surprise parties or surprise when people go around saying like, nice things, like, you know, stuff like that, I just get really bashful. I'm not used to like, I find that hard to sort of receive.

Melanie Avalon
Have I told you one of the most game-changing things for me in my life with this concept? Because I don't know if it's the exact same. I used to really not like getting compliments. I mean, it's the same thing, like it makes me feel, like I feel like I don't know how to receive, like you're saying like, I don't know how to receive it.

Like you want to kind of like downplay it or so, but then I read something and it was saying when somebody gives you a compliment, literally you can just say thank you. You don't have to say that's not true. You don't have to justify it. You can literally just receive it and say, thank you. Game changer, game changer in my life.

Barry Conrad
And to, and to clarify, like if someone says, excuse me, a compliment, it's very different, but it's more like if it's a group thing and, and they give a speech as a, I just want to disappear. Cause I feel so shy, like, you know, it's more like, yeah, I don't know why it's like a kid thing comes over me.

It's really interesting, but I'm so not shy, like put me in front of an audience and stuff. I'm great.

Melanie Avalon
Wow.

Barry Conrad
Yeah.

Melanie Avalon
Aw, we learned something new. Now we know how to navigate the world of surprise parties.

Barry Conrad
So turn up to Mel's door with balloons and everyone in the whole situation and she'll love it and she'll invite us in and make us steak and cucumbers in her robe.

Melanie Avalon
And I will have a party for you and I'll make sure everybody writes a really intense speech about how awesome you are and then we're going to all read it. Everybody's going to read it for hours.

We're all going to toast. Everybody's going to have their little speech. Yep. I'll organize this.

Barry Conrad
Does Danny like, listen to Danny, Danny, I like to call, but Melanie calls it Danielle. Does Danny like this kind of thing? Does she like surprises?

Melanie Avalon
I don't know, actually. I have to ask her. I guess we just weren't like a surprise party throwing family, really.

Barry Conrad
There you go.

Melanie Avalon
Well, shall we talk about some fasting related things?

Barry Conrad
Let's jump in, do you have a study first this week?

Melanie Avalon
I do. I'm actually very excited about this study.

It is called Short-Term Effects of High Protein, Low Carb, Ultra Processed Foods on Human Energy Balance. Okay. So let me explain why I'm so excited about this study. So I feel like we look at studies a lot or we talk about the research on fasting and protein and the effects of like if you overeat protein or if you add more protein, how does that affect your weight? It's normally we're talking about like whole foods forms of protein, like just adding more I mean, it's never like ultra processed food protein. So the purpose of this study was to see if you gave people and let them eat whatever they want, but it was ultra processed foods. If it's either high protein or normal protein, how did that affect like their energy intake, their appetite, their weight loss, all their thing, all the things. Actually not weight loss because it was kind of a short term study, but their metabolism.

So would you like to know what they found?

Barry Conrad
Yeah, tell me. That sounds super interesting. Tell me what they'll find.

Melanie Avalon
So they had two different groups. And really quickly, so in the beginning of the study, they talk about how there's this thing called the Nova classification, which, and I think we've talked about it on the show before, but it basically determines what the different forms of processing are. And so ultra processed foods are foods that have low cost ingredients. And then they're often modified by chemical processes with little to no intact, unprocessed, or mentally processed foods. And they also have additives, which are called cosmetic additives. So basically, you know, cheap ingredients, they modify it somehow, there's not really any like real food in there. And they also add in things to it. And then they talk about how over consuming these is pretty much, you know, known today to lead to it's very palatable. So we want to eat more of it, it's high calorie, and it doesn't really have good effects. And yet at the same time, what they were saying is that there's a lot of like, even though the ultra processed food industry is foods that don't seem to have good metabolic effects, they'll label them as like high protein. So it's kind of like marketed to us as a health claim, when it's an ultra processed food. So that's what they say in the beginning of the study.

And then they also mentioned something called the protein leverage hypothesis, which we've talked about before. And that is basically where the idea that people will eat to satiety with protein. So like you need a certain amount of protein and you'll be hungry until you eat enough. So they wanted to also see how that was involved with everything. So in this study, so it was 24 people, 13 women, 11 men, and it was a single blind crossover inpatient study in a whole room indirect calorie meter. So basically, what that means is these people were in a room where it was measuring by measuring the carbon dioxide levels, they could tell how much energy these people were actually burning. So you actually can like measure people's metabolisms in these rooms. So it's really tightly controlled. And then the way it worked was for the participants, they were randomized to two groups, and they would do one of the diets for five and a half days, and then like a washout period, and then they would switch the other diet. So the two diets were number one, the high protein, low carb group, and let me tell you what that included, that was a, okay, so the high protein, low carb, ultra processed food diet was 30% protein, which again, I don't even consider 30% diet, but 30% protein, 29% carbs, I don't consider that that low for carbs. And then there was a normal protein, normal carbohydrate group, which was 13% protein, 46% carbs, and both of these are being ultra processed. And so what they found was that the people who had the higher protein, oh, and again, like I said, it was ad libitum, meaning people could eat as much as they wanted, which is naturally because it's ultra processed food, that's naturally going to lead people to probably eat more.

Melanie Avalon
So in the end, the people, both groups did end up eating in a calorie excess. So they both groups ate more calories than their body needed.

So the protein leverage hypothesis, it could not prevent overeating. However, it did make the group that in the higher protein, they actually consumed less. So anywhere from 196 plus or minus 396 calories, less in the higher protein group. And so the techniques that they found was that protein, that higher protein led to less post-prandial ghrelin release, which ghrelin is our hunger hormones that actually makes you hungrier. So the people eating the higher protein, after they ate, they had less of the hormone, making them want to eat more. So it makes sense that they ate less. They also had higher PPY. And that's a hormone that increases satiety. So not only did they have less of the hormone that made them feel hungry, they had more of the hormone that made them feel full in the higher protein group.

What's interesting is this happened, even though the people that were eating the higher protein, their stomach actually emptied faster. So the food went through them faster, yet they still were less hungry, which is counterintuitive because you would think if your stomach's emptying faster, you would get hungry again. But that's not what they found. They also found this interesting. So the people in the higher protein group actually had higher 24 hour insulin levels. That might be surprising to people that it was lower carb higher protein, they had higher insulin, but that's because amino acids can stimulate insulin. So they think that's why that happened. But what was interesting is they did not have increased markers of insulin resistance. So basically, they made a comment about how you shouldn't, I'm paraphrasing, but basically this higher insulin levels, 24 hour insulin levels on the higher protein group, shouldn't be seen as marker of insulin resistance because that wasn't what was supported by the findings of everything that they were testing in these people.

The higher protein group also naturally led to a higher fiber intake. The higher protein group, they had higher metabolism both when they were sleeping and 24 hours. And the reasoning for that that they hypothesized was probably from two things, from thermogenesis. So protein just requires more energy to break down. So it's partly from that. And then apart also could have been from gluconeogenesis. So basically, the liver creates carbohydrates or glucose from protein. And that's actually an energy expensive process. So it requires energy to do that. So both of those factors together made the group that ate a higher protein, ultra processed protein to have a higher metabolism. So one of the main things that they really concluded about it though was, yes, both groups over ate. So ultra processed foods are going to probably make you overeat even if it's protein. But the higher protein, it increased their metabolism more and they ate less, but it was still in excess.

Melanie Avalon
My takeaway is ultra processed foods make you overeat. And even if they're high protein, they're probably going to make you overeat.

But if you're gonna eat ultra processed foods, make them protein because you're going to get less of the negative side effects. So yeah, what do you think about this?

Barry Conrad
Wowzers. Well, first of all, this is such an interesting study. I mean, ultra processed food, as soon as you even mentioned that is like, what is she going to say? Because we already know, you know, these foods are designed literally to keep us overeating. Like we can't, I was not surprised at all by the outcome of both groups eating more like in excess of what they needed.

Because especially because and also the whole thought of these foods still being marketed as healthy, you need this protein. So get this, it's still healthy, even though it's processed and people reach for that on the go. I thought it was really interesting that the higher protein group actually increase their metabolism, even though it's ultra processed food, that was not something expected, because it's within ultra processed food context. So it's what so their body just still worked harder to process the food then also, I wonder why that is.

Melanie Avalon
and it was in comparison to the other group. So basically eating more protein, they saw in the metabolic rates of the two groups, it would have been nice to have a control group, you know, that was eating maybe whole foods.

So basically, if you ate that, if you ate more protein, processed protein, you would burn more calories, but it but none of it is enough to make up for overeating that's going to happen from it all being ultra processed.

Barry Conrad
It also makes you wonder, like, does the metabolic boost from the high protein, like some people might go, it doesn't matter if the boost is from high protein, if you're still overeating ultra processed food? Like does it, you know, as long as you're still having protein, or is the insulin rising just from protein or is it the way it's processed?

That was interesting, too.

Melanie Avalon
Yeah, that was really, really interesting to me. It was interesting to me and I'll actually read the sentence that I mentioned about.

They said that the postprandial insulin, so what they did is they looked at the insulin to glucon ratio that can indicate the role of insulin resistance or not. So it was lower in the high protein group. So they said that the improved glycemic control during high protein, low carb, ultra processed food, despite a high calorie intake and high glucagon, suggest that increased insulin secretion in the situation does not reflect insulin resistance. So there was more insulin secretion, but it was not a negative insulin resistance type situation, which is very interesting.

Barry Conrad
Also, you know, it suggests I guess their bodies are working much harder to process the food, but still not enough to balance out the excess. It's like you can't out eat.

You also can't win. When you're eating ultra processed food, I know from experience, you want to keep eating it. It's so hard to stop. It's hard to have moderation with that.

Melanie Avalon
I agree so much. I'm trying to see what they actually like what their actual conclusion conclusion was

Barry Conrad
Also, to me, that's not really low-carb in the high-protein low-carb group. I know. 29% carbs is not low-carb, right?

Melanie Avalon
Not in my book. I mean, that's more just like, to me, like moderate cards, especially if people are doing like a balance, like 30, 30, 30 or the way I found this actually was I, it was a, it was a situation where I was reading another, I was looking for something else and then I saw it referenced and I saw the title and I was like, oh, this looks so interesting.

So yeah, this was published by the way in March of 2025 and nature metabolism.

Barry Conrad
such a awesome fine melon. And you know what, the, the jarring reality is now that I'm America, there's I was walking the other day, going from store to store, there's like so many stores, like every other stores, like a whole new grocery store, and like aisles of ultra processed snacks.

And like, there's no shortage. And I'm like, I need to really also like, if I can practice self control, and it still can be tempting at times, imagine what the everyday person must go through with just being bombarded with so many options.

Melanie Avalon
So does it look, I'm really curious by that. So it does, it's different, it's a different experience than walking around in Australia, like the food that you see everywhere.

Barry Conrad
Very different. First of all, the volume of it is insane. Like so much food.

Second of all, the ultra processed stuff is so cheap. I mean, that is sort of similar to Australia. But just yeah, it's scary how many options there are, especially in the ultra processed.

Melanie Avalon
Wow. That's so interesting. Yeah. Welcome to the US. Have fun!

Barry Conrad
But in saying that I also love the good thing is I also love that there's so much because there's so many options for other things like different is literally something for everyone, really.

Melanie Avalon
Yeah, this is true. We represent like, like all the different countries, you know, like you can get all the different food and so you can navigate it though.

Like I'm just saying like for me, like I, I have to like just not even I just don't even look at it.

Barry Conrad
Do you know what, Mel, I think you mentioned this before, but like you said, I think you said something like when you get to the US, it's going to be interesting how you go out. I'm trying, like this is the first week where I'm properly sort of eating the way I did in Australia because the first week was a lot of celebrations and a lot of going out and stuff like that.

So I need to find, find my staples here, I don't have my staples yet or like the brands that I like. So I need to probably take a little while to get that right. The brands of, you know, beef and da, da, da, everything, you know.

Melanie Avalon
Well, you know what I'm going to say to that, right?

Barry Conrad
All foods. Yes.

Melanie Avalon
Yeah, and this is where really like the whole walk around the perimeter of the store don't go in the aisles thing really helps.

Barry Conrad
It does help, although I did that the other day, actually today, earlier today, and I went to the outside and I saw lines of corn chips and I'm like, oh, damn.

Melanie Avalon
Oh, yeah. I mean, you gotta, yeah, you have to just like put on, it's like the opposite of beer goggles. Like you have to put on the goggles that just show you what you're going for.

Barry Conrad
Exactly.

Melanie Avalon
So, oh my goodness, keep us updated.

Barry Conrad
on my food adventures. Yeah, and just navigating. Yeah, definitely.

Melanie Avalon
Yeah. Well, thank you.

I'm glad you enjoyed it. I really, really liked the study. I thought it was so interesting. And just to put a bow on it, it is kind of frustrating to me like, and like the article talked about and then you commented on as well, like these foods are so bad for you. And yet they market them as being healthy, you know, like high protein. And it's like, it's like the worst of it is like when you see the breakfast cereals and they're like, heart healthy, like ADA certified, it's like how in the world is a, the American Heart, right, or AHA certified, how in the world is the American Heart Association, like certifying any breakfast cereal? I, I just cannot.

Barry Conrad
Yeah, it's crazy. It really is.

And people like a lot of people at time pause. So then they'll want to go into the store, maybe in a hurry, and they'll see like a bag of something that looks appealing that says protein, but it's like a bag of chips. I'll grab that, you know.

Melanie Avalon
The high protein thing kills me, like it, so look beyond the labels, just get the real protein. And you'll be a lot better off. Alright, so we jump into some listener questions.

Barry Conrad
Let's do it.

Melanie Avalon
So we have a question from Claudine. This is from Facebook and the Facebook group is IF Biohackers Intermittent Fasting Plus Real Foods Plus Life. And Claudine says, the social aspect of fasting is the toughest for me. My eating window closes mid-afternoon. So anything I do in the evening where food or drink is involved leads me to skip that fast, leading to inconsistency.

I've tried, but I can't move my eating window to evening only, it completely wrecks my sleep. So do we have help for Claudine?

Barry Conrad
We sure do. Claudine, thank you so much for your question. It's a real life challenge, and you're doing your best for the sounds to stay consistent with your fasting. You've found a routine that technically works for you and then come along to the dinner with the friends and the spontaneous hangs of the birthdays or the date nights and suddenly you're off track. It can be frustrating.

I've been there. It's not necessarily about discipline, it's just life. It can really happen. So first of all, you're not alone. The structure there makes sense. Like you eat, you close the window, and your evenings, they're clean and simple, but socially, it can feel isolating sometimes, the tension between goals and connection. I totally get that. I also hear you on the sleep situation. You've tried moving your eating window and what you're saying here to later, and it's not working for your body. And that can be a really common pattern, especially for people who are a bit more cortisol sensitive. For some eating later, especially heavier meals or meals with sugar or alcohol, that can really wreck your sleep or really hurt your sleep, spike your stress hormones and leave you, I guess just not getting that quality seat that you need. So I completely understand why that's a no go.

So what do you do? I think this is where the flexibility is gonna come in a bit more. So you've already got self-awareness, so you know that shifting your whole protocol to the evening throws things off. So maybe I'd suggest it isn't moving your whole window, maybe create a plan for this, maybe the special festive occasional situations. So something like intentionally doing a longer fast before the event maybe, or opening it, even a second little mini window, maybe with something light in the evening, or even just reframing that as a, like a maintenance day, planning for that. I mean, I know for myself, if I know something's coming up, I'll be, I can maybe tighten things extra tight and during the week and then for that week and I know I'm gonna maybe have a bit of a longer window and I plan for that, plan for those indulgences. And that's not a fail, the goal isn't to be perfect here, it's to be consistent over time.

And it's also something that's gotta fit into your life. You know, it's really important that that happens. So if you're fasting clean five or six days a week and then occasionally pausing for something meaningful with your friends and your loved ones, you're still building incredible metabolic benefits, that's not going away just with those one off moments. And emotionally, that freedom can actually take a lot of pressure off and motivate you for the week ahead. Another idea, you could keep your main eating window maybe as is, but sip on something like a sparkling water, or even like a non-alcoholic drink at a vent, so it's not too calorically dense or it's not gonna derail you. It sounds simple, but a drink in hand, even if it's just water without anything in it, and I think Mel and I have talked about this before too, it could just take the social pressure off as well if that's something that bothers you, even if it's just literally water.

Barry Conrad
And when you do choose to eat or drink, you make it worth it, not feel any guilt, no awkwardness, because you made that choice. So you're clearly being intentional, Claudine, I love that, just remember again, that's not a diet, this is a lifestyle, it's gotta fit into your life and be sustainable.

You're allowed to bend and break with, without breaking the whole rhythm of throwing the baby out with the bath, that doesn't have to happen. Your sleep matters, your joy matters, and the fact that you're even asking this means you're tuned in and doing the work. So, Mel, what do you reckon?

Melanie Avalon
Awesome. You, you pretty much said all the things I was gonna say, which is basically, you know, there's different routes and ways that you can approach it. But first of all, before that, I love what you're saying about the mindset. So I literally wrote for one of my notes, I wrote Don't Sweat It, but I don't mean Don't Sweat It. But what I mean is getting rid of the anxiety and stress and you know, reprimanding yourself for what you're doing is not going to help anything.

So being open to being more flexible, like Barry was saying, I think is great. I think it'll help so much. And then when it comes to the actual, like what to do, Barry just kind of ended with it, we've covered it before, you can choose not to break your fast. And that is an option. And that and really the thing with that is more about, I mean, it's funny, it's hard, like, it's more about being comfortable with yourself and what you think people think of you rather than, you know, any struggles with fasting for most people. So like Barry was saying, if it's like, if it's not like an actual like dinner, and it's just like a party situation, people really, I mean, if you're holding a cup of something, like Barry was saying water, like people really don't notice people are often more times focus on themselves and other people. I do get how if it's like an actual dinner type thing that can be awkward. I mean, I am really good at not well, actually, I typically like drink because then I eat later afterwards. So I've been doing this so long that I'm comfortable with it. I really get though that that, you know, a lot of people are not open to that. But I really like the idea because the other thing I wrote was was changed food. And what I what I meant by that was, you don't talk about what you're eating. So the and you don't talk about your goals or anything like that. Besides not wanting to wreck your sleep, which is really important. But basically, it's like, where are you in your fasting journey? So if you're just at maintenance, then a day of changing your fasting is probably not going to change much, especially if you don't go crazy. And or you do things like Barry said, where you kind of, I don't wanna say compensate, but make adjustments later to kind of like balance things out. So maybe you have more on this one day, because you're going out in the evening, and you're gonna have more. So then maybe the next day, you have just like a tighter window. Or if you haven't adjusted your food choices, there's a lot of power in the food choices aspect. So maybe, you know, the day when you're going to have a longer eating window, you make more conscious food choices about what you're eating. So there's a lot of flexibility here. I and I guess she doesn't say how often this is happening. She just has social aspect and anything I do in the evening. So is this like once a week, or once every other week? Or is it like, all the time? So that's that's a big question. But basically, I, I wouldn't stress about the inconsistency part, because that doesn't necessarily have to be a problem. And you can adjust for it.

Melanie Avalon
Yeah, I feel like I just said a lot of what you said. And then the completely wrecks your sleep part of it. It's so funny how like some people like I sleep so well on a full stomach, and some people don't. And it's so interesting how people are really individual that way.

I actually was interviewing Seamland. Do you know, do you follow Seamland? Do you know him? I don't know. I've been following him for years and years. He's beyond brilliant. He's from Estonia. He's really big in the biohacking movement. His books are he's young too. He's so young. He's like, he's so young. He's like much younger than me. And he's brilliant. And he has so many books and they're the deepest dive ever into health related things. And so he's he has one like on autophagy, like fasting. So I brought him on recently for his newest book, which is called The Longevity Leap. So it was the deepest dive that I have seen, honestly, into all the things affecting aging, how to reduce your biological age, it was fasting, diet, all the different diseases that we get, you know, how to what they mean.

But we were talking about eating windows, he talked about he talks in the book about how, yes, it probably seems like eating earlier is better from all the data. But it's also really important that you do what works for your chronotype. And some people, you know, stay up later. And what he was saying that he used to sleep on a full stomach, then he got married, and she wanted to eat earlier. And they both do fasting. Now they eat earlier. And he said now he enjoys going to bed on an empty stomach. And I was telling him, I was like, okay, I'm really curious if I actually if somebody forced me into that, if I would actually like it eventually. Like, how about you? Like, because you you you don't like going to bed on an empty stomach, right?

Barry Conrad
No way. I've been fasting for seven years plus now, and I'm used to having my own med later in the day and feeling satiated, satisfied, and not hungry.

Melanie Avalon
Yeah, like the idea of going to bed on an empty stomach, it's just so miserable to me. But it's interesting though, like maybe that it can change for people.

So one other idea I'm having talking about this, I'm curious like what aspect of it, you know, makes you like, wrecks your sleep. Maybe if it's like an eating situation, you can just eat like lighter at the dinner. You know, like maybe it doesn't have to be all or none. Like it doesn't have to be like, I'm having all this food because it's dinner. Maybe you just have like a longer eating window, don't stress it. And just eat light like a small appetizer. There might be a way to get best of both worlds.

Barry Conrad
It's honestly so, it's so doable. It really is.

Melanie Avalon
Okay. Do you think we should have our proverbial breaking fast moment?

And actually, before we jump into this, Barry, I was just thinking, because for listeners, we're recording in the evening. And I always have to, because I'm in an apartment, I'm on the fourth floor, I always have to, like, when we start recording, it's light outside and then it gets dark. So I have to close my windows. But your situation, are you you're high up, right?

Barry Conrad
I'm high up in a high rise and like on the 30th floor, it's now dark, like the sun doesn't sit here in New York until after eight. At the moment now it's late now, so it's like, it's 9.24 now, so the sun's well and truly set now.

Melanie Avalon
I'm just kind of jealous. I was thinking about this when I was closing my windows.

I was like, it would be nice because you don't have to worry about people, you know, like seeing in your apartment. It would be nice to be able to just keep the windows open.

Barry Conrad
Well, actually I'm looking out right now. It's such an amazing view. Oh man. Did I send you a photo?

Melanie Avalon
Yeah.

Barry Conrad
I did, yeah.

Melanie Avalon
You can see me more, though. I love photos.

Barry Conrad
It's I love looking out at the lights

Melanie Avalon
See, that's so nice. Do you close the windows at all?

Barry Conrad
not in the living, actually, no, not at all, not at night because, you know, no, just leave them open because it's like, it's too far away. It's too high up.

Melanie Avalon
Yeah, so I'm jealous is my point.

Barry Conrad
Well, you could leave yours open, no?

Melanie Avalon
No, no, no. That's what I'm saying.

I'm on the fourth floor and I'm in a courtyard. So directly across from the... If you look at my window, it's other apartments looking back at me. So people would see straight in.

Barry Conrad
That's not good.

Melanie Avalon
Yeah, which we can't have

Barry Conrad
We can't have it.

Melanie Avalon
Okay, so for our proverbial breaking of the fast moment, what restaurant do you have for us, Barry?

Barry Conrad
Okay, Melanie, I actually have a restaurant that you may even know of. I'm sending it to you right now. See if you know it.

Melanie Avalon
Wait, did we do this one on the show yet? Did we not?

Barry Conrad
I don't know, have we?

Melanie Avalon
Wait, this is one of my favorite restaurants in Atlanta.

Barry Conrad
It's called canoe. I don't think that we've done it.

It's nestled along the Chattahoochee River in vinings with serene waterfront gardens and walking paths. It is inducted to the nation's restaurant news fine dining hall of fame. And their wireless is thoughtfully curated to complement fresh, elegant fare. And apparently the vibe is pretty romantic, yet relaxed, which is great for milestone dinners or casual date nights by the water.

Melanie Avalon
Okay, so this is wild because when we first, because when we first decided to do this restaurant idea, I was like one of the first restaurants I'm gonna do is canoe because it's one of my favorite restaurants in Atlanta.

Barry Conrad
Really?

Melanie Avalon
Yeah, it's not my favorite. It used to be. It used to be my favorite.

Barry Conrad
So this is a first because there's never been a restaurant where

Melanie Avalon
We've been, no, no, no, no, no, old Disney, I've been to.

Barry Conrad
Yeah, that's right. But this is like in your hood in your

Melanie Avalon
It's really exciting that you picked it and I've been already.

Barry Conrad
That is actually pretty cool.

Melanie Avalon
Oh my goodness. Yeah. So what's really cool about canoe, I'm just like, go, go on this. Actually, it was funny.

So I've only gone at night, apparently has stunning views of the river and you can go for brunch and see it, but I've only gone at night. So I've actually never seen the river outside. The menu is very, they have a lot of food that you, like they have kangaroo, they have, which I know is a big, which I know is everywhere in Australia, but we don't have that here normally. They have like a kangaroo appetizer. They have like a rabbit. I've actually had a birthday dinner there. I've had dates there. I've gone out with friends there. It's, I love it.

Barry Conrad
Well, off to go then. That sounds great. I'm so glad that you've been there and that you like it. That's awesome.

Melanie Avalon
I do, yeah, yay, okay, this is so fun. Okay, so you go to the menu.

Barry Conrad
goes to the dinner menu, so I'm really interested then to see what you choose because you'll know exactly what you'd like, like more so than normal.

Melanie Avalon
Yes, this is cool. I know. I know. Last time I went I went over the holidays.

I went to the bar actually. But yeah, I've eaten there. I think I've eaten there maybe three times. And what's cool about it too is the location of it. It's not. So most of the most of like the like well known restaurants. I'm just thinking about how I wish that you were like here more in all the places we could go. But they're in like Midtown or Buckhead or downtown Atlanta, like they're in areas. This is kind of like just like off, like by itself. Somewhere, which is kind of cool. Appetizers, we get to use the US language.

Barry Conrad
Yes. What would you get seeing as you've been there?

Melanie Avalon
Let me... Oh, look what they have. You see what they have, right? Oistas. So I'm gonna get the... Wait, do they not have the kangaroo right now? Oh, yeah, they do.

So I'm definitely gonna get the peppercorn-crusted kangaroo loin. It's so good. It's rare. Well, actually, do I order it rare or is it always rare? I'm trying to remember if it's like tartar or not. I'm gonna get that. It's really good. Wait, question. How often did you eat kangaroo in Australia? Like, do people eat it all the time?

Barry Conrad
It's so easy to get so accessible and it's like it's like you are people have ground beef mints. It's like you can get like kangaroo stir fry. So it's like it's not like a just a fancy restaurant thing. It's like a everyday grocery store. Yeah.

Melanie Avalon
It's so lean.

Barry Conrad
Yeah, so lean.

Melanie Avalon
And I don't think it's legal in every state here.

Barry Conrad
That's surprising because it should be, it's also so high in protein as well.

Melanie Avalon
Yeah, it's like so good for you. I remember when I first found it.

I think it's Because I think I remember I would get it here. I would buy it here and I think I moved to california and I couldn't get it maybe Okay, so i'm gonna i'm gonna get two things i'm gonna get the the kangaroo, but i'm gonna so the way it normally comes prepared Is peppercorn crested kangaroo loin with bulgogi pork belly edamame soba noodles colby butter oreo oreo oreo furikake I would get a plane but barry. Do you want to try some like do you want me to get it like with the stuff on the side

Barry Conrad
Yeah, because I was going to order that as well, but I'd rather try some of that and order two of my own ones.

Melanie Avalon
Okay, so that and then I also would like some cold smoked Atlantic salmon, which comes with crispy potato cake, creamy goats cheese, caper dill cream. Again, I would get it plain, but do you want the stuff on the side?

Barry Conrad
Sounds good.

Melanie Avalon
Okay. Oh wait, they have Georgia white shrimp?

Barry Conrad
Yo, I'm gonna get that.

Melanie Avalon
Okay, okay.

Barry Conrad
All the good stuff. I'm going to get the Georgia white shrimp and the cold water oysters on the half shell, 40 of them, please.

Melanie Avalon
Oh my goodness.

Barry Conrad
So excited.

Melanie Avalon
I don't actually think that's the price, so there must be like two sizes.

Barry Conrad
I'm sorry, it was the other surprise.

Melanie Avalon
So you want the large size, basically.

Barry Conrad
Yeah, I want the large size, the full situation.

Melanie Avalon
Awesome

Barry Conrad
So we have the entrees, it's mains, the mains.

Melanie Avalon
No, but it's not called it here, entrees. I like that we respect the menu, you know, we respect the terminology of the menu. Okay, so entrees.

Barry Conrad
It all looks so good. It looks like a great place.

Melanie Avalon
It is good. I really like it.

And I can tell you, so I always wanted to order the Blue Ridge Rabbit, but they pre marinated in something so I wasn't, it doesn't, you can't get it without like a marinade.

Barry Conrad
Hmm

Melanie Avalon
Okay. I'm trying to remember what all I've had here.

I think I'm gonna get the, yes, I'm gonna get the maple marinated Rohan duck breast, except not marinated because I remember they couldn't make it without the marinade, which comes with toasted jasmine rice, red beans, jerked mushroom, pineapple pickle, but I'm gonna see instead if they can substitute and just give me like steamed spinach, if they have that. Mm-hmm. With some, yeah. Maybe some garlic. How about you?

Barry Conrad
I'm going to get the oven roasted Dürich pork chop.

Melanie Avalon
I was just looking at that and that was my, I was like, wait, should I have gotten that? Okay. I'm glad you're getting that. Sorry, I interrupted. What is it?

Barry Conrad
that's okay you know how the at the end they say chard avocado chard chard chard chard chard

Melanie Avalon
Are you going to ask for it to be non-chard? No, cool.

Barry Conrad
Didn't you say Chod's bad when it's meat, right?

Melanie Avalon
Anything Barry

Barry Conrad
I don't know. I feel like I need to respect the menu. Respect the terminology, respect the... I'm going to get that and I'm also going to get the scallop. That looks good too as a second situation.

Melanie Avalon
Would you like to read it?

Barry Conrad
Yeah, so it's called the Agnolotti of Georgia's Bank Scallop Dash Ramps. It's grilled baby carrot, minted English pea cream, shaved radish served with that.

It looks really good. And I think something light to have with the oven roasted Duroc pork chop, which I think would be quite good.

Melanie Avalon
And how are you going to get the pork chop prepared?

Barry Conrad
Medium rare.

Melanie Avalon
Oh, okay. Wow. I think we will go medium with pork.

Barry Conrad
Yeah, because you still can have it a little bit rare.

Melanie Avalon
I mean, I'm a bad person to ask. I'll eat anything like rare.

OK, and then I'm actually surprised. I don't know why I thought you would get it, but I kind of thought that you were maybe going to get the duck and beef burger.

Barry Conrad
Thank you.

Melanie Avalon
Yeah.

Barry Conrad
Oh, whoa, whoa, whoa. Did I miss that duck and beef? Ah, can I change my order?

Melanie Avalon
Oh my goodness, I know you so well.

Barry Conrad
Okay, I'm going to delete the scallop.

Melanie Avalon
OK, wait. Oh, you're going to. OK, that's fine. Yeah.

Barry Conrad
And I'm going to keep the duck and beef. Duck and beef burger. It's got sunny side egg. So does the sunny side egg perfect so it can melt all over the burger.

Pickled red onion herb truffle fries. Let's go. I'm so excited about that.

Melanie Avalon
Oh my goodness. I'm glad I pointed that out.

Good thing you have me here. We'll be at the restaurant and you'll be ordering. I'm like, wait, and I'll like stop. I'm like, he doesn't want that. I think he missed something on the menu.

Barry Conrad
Are you going to just, you're going to have to put up with my, uh, eating. Cause I, I really go in when it comes to burgers, I'm not trying to look cute. I'm just eating it, pick it up with my hands.

Melanie Avalon
I love it. I love it. It makes me feel less self-conscious about my eating, which I'm still going to eat, you know, the way I told you.

Barry Conrad
You tell people to look away and stuff.

Melanie Avalon
No, I just, I cover my mouth and I, I eat like very small bites and I go very slow. So like, when I'm at a table with, you know, lots of other people, I'm always the last person eating and I'm going slow.

And then they want to like take my plate. I'm like, no, I'm still working on that.

Barry Conrad
You know what when people take your plate before it's actually kind of offensive like that happened to be the other day like this still like one or so left.

Melanie Avalon
Yeah, I know why they do it though, because having been a server for a very long time, sometimes you're trying to, you know, get people to move along. But okay, desserts.

Barry Conrad
There's a, what are you, eyeing?

Melanie Avalon
So there's something here that I hope, I think I know what you're gonna order. I hope you order it because it's very unique.

Well, I'm giving things away. If I were, I'm gonna ask for obviously, I think I'm gonna get the pork chop for dessert.

Barry Conrad
I just don't, I don't know anyone in my, I've never ever met anyone in my entire life who orders them like a mains or a savory dessert.

Melanie Avalon
I'll probably get kangaroo again for dessert actually. Like a, yeah. I'll probably get like another round of kangaroo and salmon from the appetizers for dessert. I love the kangaroo, it's so good. And I can't get it anywhere. We should really actually really go here because then you can talk about kangaroo.

Barry Conrad
That'd be awesome, I'd love that.

Melanie Avalon
Okay, well, to-do list. If I were ordering a dessert, I would get, well, I'll let you go first. What would you get?

Barry Conrad
I would get the Georgia strawberry brulee and also the hummingbird cake.

Melanie Avalon
Okay, so you didn't get what I thought you might pick.

Barry Conrad
It's going to get the Republic adult down.

Melanie Avalon
I thought you were going to be intrigued by the popcorn ice cream.

Barry Conrad
You know, I don't know, like I don't love like popcorn on ice cream sound like that's a bit too much.

Melanie Avalon
Have you had that before?

Barry Conrad
Because in Australia, do you do this thing where you take like an ice cream and you dip it into your popcorn in the movies and eat it?

Melanie Avalon
No. Okay. So this explains why you didn't order it. So this is like not kind of like, this is weird. We don't do this here.

Barry Conrad
It's not a novelty. So it's like, okay, I've tried that before. It's, it's okay.

Melanie Avalon
Oh, okay. That explains. Okay, because I need to like explain why I got this wrong.

Because I think if it was a novelty, you would have been like, Hmm, but it's not clearly. Yeah, we don't do that. We don't. That's not a thing here. I don't think

Barry Conrad
You do it in the movies and as you get your pop your box of popcorn and then you buy like it's called a chalk top and it's like a you know the ice comes in like a rapper but you buy you take off the shell of chocolate you buy through that and then you dip the vanilla ice cream pie into the box of popcorn and eat it off it's just a thing in Australia.

Melanie Avalon
Whoa. Do you guys have Dippin' Dots? What's that? Okay.

Okay. So, okay. Hey, I've never heard of this little like popcorn concoction magicalness alchemy thing you do. We don't do that. The ice cream we do is Dippin' Dots.

Barry Conrad
I don't know what that is.

Melanie Avalon
Oh my goodness. Okay. So we have to go to a movie that has a Dippin' Dots machine if they still have them. So this is what, okay, ready? Imagine yourself being like a little kid, because that's when I did this last. And you go to this machine, it's called Dippin' Dots. And it's basically like ice cream from the future. I literally think that's the tagline. I think they're like Dippin' Dots ice cream from the future. And it's like little tiny, tiny little balls of ice cream. And there's different flavors like, you know, vanilla and chocolate and Oreo and birthday cake. And then the way they do it from the machine is you pick your flavor and then it's like a vacuum and it's like this thing comes down and like vacuums up the Dippin' Dots and gives it to you and then it comes out like a vending machine.

You should Google it, the Dippin' Dots. There's a rainbow. I'm going to Google it, Dippin' Dots. This is mind blowing to me that they don't have this in other places. Oh, wow. That actually looks really good. And it's okay. I'm looking at pictures right now, friends. I'm getting so many flashbacks. I can taste it right now. I can taste it. I can literally taste it.

Barry Conrad
Cause I was just at the movies on like last week and I didn't, well, we didn't have any time to get snacks, but maybe this was right there.

Melanie Avalon
Look around actually and like report back because I'm guessing they still do this. It is so good

Barry Conrad
Oh my gosh, I need to try it. Okay, next time, the next movie is happening probably, I think, this weekend, so I'm gonna look for it.

Melanie Avalon
see if they have a Dippin' Dot machine. And also next time we record, I have an article that came up and it was about Australian desserts.

And I wanna like go through them with you and see if they're actually real or if this is lies.

Barry Conrad
All these Australian myths need to debunk.

Melanie Avalon
I know, I know. Okay, so you're getting the hummingbird cake.

Barry Conrad
and the Georgia strawberry brulee that looks really good.

Melanie Avalon
Have you had hummingbird cake before?

Barry Conrad
I don't think so.

Melanie Avalon
Do you see the ingredients? How do you feel about that?

Barry Conrad
Banana, mascarpone, pineapple. I just think cake, I like cake, you know.

Melanie Avalon
I do too. I'm a cake person.

Barry Conrad
So I'm interested to see what the concoction would taste like.

Melanie Avalon
Yeah, I think I would probably actually the two things you picked if I were getting one, I would get that I want to I would want to try the hummingbird. I am intrigued by Georgia strawberry brulee.

Barry Conrad
Okay, Mel, if you click on the cocktails thing, it has the by the glass wine and cocktails on it.

Melanie Avalon
Yes. And I've actually, you know, like I said, recently been here. I'm trying to remember what I, I remember I took a long time looking through the list. What did I actually end up getting? I think, oh, okay. I see one that I recognize. The, the Pinot Noir, patriarch, Paris Feels, Borgone. I think that's probably what I would get.

I know. I think that's organic. How about you? Is there a cocktail that speaks to you?

Barry Conrad
Yeah, let me look here. What's it called then?

Maybe the, um, maybe the Tom Riddle, cause it has bourbon in it. And then I'll also get a, I think, you know, I might actually try some of the peanut, no, I you're getting, cause I think, you know, having, I'm having the, the meat and stuff as well. And then I might have like a whiskey on the rocks later as well. But yeah, Tom Riddle, one of your pinot noirs and maybe like a whiskey on the rocks afterwards.

Melanie Avalon
Tom Riddle's the Harry Potter reference, right?

Barry Conrad
Is it? Yeah, this transformative cocktail includes Mitch's bourbon housemate. Yeah, maybe it is.

Melanie Avalon
Yeah, Harry Potter. There you go. Awesome. Okay.

Well, we're going to have to go. And now we definitely, we were just talking about how we need to do more social media with stuff. We definitely have to like, for this post, I have pictures of being there.

Barry Conrad
We should put that in there, like a carousel or something, you know?

Melanie Avalon
Yes, I'm gonna make a note, add Melanie's pictures to Instagram, perfect. All right, how did you find this by the way?

Barry Conrad
I just, you know, as I always do, I just go for a deep dive and just look for interesting restaurants. And then I was like, Hey, this is in Atlanta. I'm wonder if Melanie's been there.

Melanie Avalon
Oh, well, you found it. You did not. You were not looking for Atlanta restaurants. No. Whoa. Mind blowing. So what list was it on? Like what? Do you remember?

Barry Conrad
I actually don't remember. I'd usually just kind of look for... I'd go by the structure of the restaurants that I've had before and do a search sort of like the same sort of feel or like, you know, good things about it, good wine list, and then a whole bunch of stuff just pops up.

Melanie Avalon
wow okay that's even more mind-blowing because i was like oh he was like i'm gonna find a restaurant in atlanta in honor of melanie i'm so self-centered that i literally i had that whole narrative in my head oh my gosh wow that's amazing that's so cool yeah they're they're super cool like i said it's been they were at one time when i first moved to atlanta a while ago they were my my favorite restaurant and then i found some others but i do really like them so

Barry Conrad
It looks really good, like really, really good, actually.

Melanie Avalon
we should go. It has good lighting too, by the way, which actually, just to like quickly give a note, I actually, if I have to put the hierarchy of what's important to me in a restaurant, I think number one is lighting.

How do you feel about that statement?

Barry Conrad
Yeah, because you can't eat in bad lighting.

Melanie Avalon
I just cannot. So like, it's actually more important to me than the food because the food could be amazing.

Everything could be amazing. The theming could be amazing. But if it's like bright lighting, I just don't want to be there.

Barry Conrad
Yeah, it was jarring, like, elevated, yeah.

Melanie Avalon
So the lighting here is, it's very dark. They have booth, they have the booths that I like that are like the, I don't know how you describe it, like the wall booths where it's very like, very like very big booths where like a party of five can sit, but you're all like in the booth.

Barry Conrad
That's cool. Also, they have a dress code that says Canoe upholds a smart business casual dress code.

Melanie Avalon
Yes, I like a dress code. I'm always down for a dress code.

Barry Conrad
Hey, this is a woman I encourage to wear pant-slash-skirt suits. Wear dresses or pant-slash-skirt suits. There you go.

Melanie Avalon
Art suits. Oh, that's like where you have like the like the blazer, I guess.

Barry Conrad
Well, it's really, it's very specific. I like that though. Cause it adds to the vibe where, you know, it's, yeah, the whole feeling.

Melanie Avalon
What's interesting about it is because I was talking about the location, so everybody who comes there is very intentional. You're not just going to accidentally show up.

All the other restaurants are in places where you might just walk in because it's like you're in midtown, you're in downtown, you're in Buckhead, but here you have to choose to go there. So I feel like people who are there are very intentional about being here, if that makes sense.

Barry Conrad
I get what you're saying. Also, where are we going? Can't wait.

Melanie Avalon
I know, can't wait! Shout out to Canoe!

Barry Conrad
And then you'll be like, he's not getting that, hold on, he's not ordering that.

Melanie Avalon
Yep. All right. Well, this was so, so fun. Thank you so much, Barry and the listeners for all the things.

Listeners, you can go to ifpodcast.com slash episode 439, and there will be a transcript as well as links to everything that we talked about. So definitely check that out. And you can follow us on Instagram. We are ifpodcast. I am Melanie Avalon. Barry is Barry underscore Conrad. And also congrats to you, Barry, for maybe rapping Destiny when this airs.

Barry Conrad
Thanks so much, really appreciate it.

Melanie Avalon
So, this was so much fun, anything from me before we go?

Barry Conrad
Thank you so much as always for spending part of your day with us listeners and we'll catch you next time and I'll talk to you next week.

Melanie Avalon
Talk to you next week.

Barry Conrad
Bye!

Melanie Avalon
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed.

If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by podcast doctors, show notes and artwork by Brianna Joyner and original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week!


 

 

Sep 08

#438 – Special Guest: Dr. Chris Meadows, Fasting For Surgery Recovery, Resolving Chronic Pain, College Sports Injuries, Supporting, Not Stopping, Inflammation, Curing Arthritis, Stem Cells & PRP, Muscle Growth & Protein Intake, Natural Anti-Inflammatories, And More!

Intermittent Fasting

Welcome to Special Guest Episode 438 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, biohacker, founder of AvalonX, and author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine, and Barry Conrad, actor, singer-songwriter, and creator and host of Banter with BC


Dr. Meadows is a dual boarded physician holding certifications in both Physical Medicine and Rehabilitation as well as from the American Board of Electrodiagnostic Medicine. Dr. Meadows has expertise in neurological rehabilitation, musculoskeletal medicine, diagnostic and procedural ultrasound, and electrodiagnostic medicine. His background as a collegiate athlete at the University of California of Los Angeles where he played cornerback and wide receiver for the Bruins, was instrumental in developing his passion for sports performance. He carries what he’s learned in these experiences to develop a unique and scientific approach to patient care where he incorporates principles of exercise, nutrition, supplementation, and recovery guiding patients to maximize their own performance either at the gym or in the work place. His training in Physical Medicine and Rehabilitation gives him a keen understanding of tissue specific modalities for optimal performance and healing. This set him up with a great foundation and a natural pathway towards Regenerative Medicine, where he has focused his most recent efforts into understanding and applying. His Regenerative Medicine approach focuses on best practices for health optimization, injury recovery, and age reversal.

Dr. Meadows has always enjoyed teaching. In residency he was peer-elected to be Chief Resident where he supported curriculum development. He has maintained his academic roles over the years serving as the Associate Program Director for the St. Luke’s Rehabilitation PM&R Residency Program, Clinical Assistant Professor at the Department of Medical Education and Clinical Sciences at the Elson S. Floyd College of Medicine at Washington State University, and Clinical Faculty through the University of Washington School of Medicine. He’s also contributed as an author to major medical texts in the field of Rehabilitation Medicine.

Outside of work, Dr. Meadows puts into practice what he teaches by committing to a life of health and fitness with regular exercise and focus on nutrition. He enjoys strength training including olympic lifting and has recently taken up racing triathlons. He also remains passionate about youth sports by volunteering as a coach for his young children and running athletic development programs for high school and college athletes.


WEBSITE | IG 



SHOW NOTES


SPONSORS & DISCOUNTS


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Links:

The Melanie Avalon Biohacking Podcast Episode #211 - Christian Drapeau

The Melanie Avalon Biohacking Podcast Episode #280 - Christian Drapeau

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts!

Original theme composed by Leland Cox, and recomposed by Steve Saunders.


Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.


TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.)

Melanie Avalon
Welcome to episode 438 of the Intermittent Fasting podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, founder of AvalonX and author of What, When, Wine, Lose Weight and Feel Great with Paleo Style Meals, Intermittent Fasting and Wine, and I'm joined by my co-host, Barry Conrad. Actor, singer-songwriter, and creator and host of Banter with B.C. For more on us, check out MelanieAvalon.com and BarryConradOfficial.com. You can submit questions for the show by emailing questions at iapodcast.com or by going to iapodcast.com. We would love to hear from you.

Please remember the thoughts and opinions on this show do not constitute medical advice or treatment. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine. If it's that time and get ready for the Intermittent Fasting Podcast. Hi everybody and welcome. This is episode number 438 of the Intermittent Fasting Podcast. I'm Melanie Avalon and I am here today with a very special guest that I am so excited about because we are going to tackle a topic that honestly we get questions about all the time and we have never really had an expert on to address it. So the backstory on today's conversation, maybe like a year ago or so, our mutual friend, Ben Greenfield, who has been on the Melanie Avalon Biohacking podcast, introduced me to an incredible doctor, Dr. Cameron Chestnut, and I had him on that show. The topic, he does a lot in the world of cosmetic surgery and cosmetic procedures with a, I would say like a biohacking, like a holistic, a regenerative medicine, a biohacking type approach. And so friends, if you have questions about all the cosmetic things like surgery and fillers and Botox and everything like that and recovery, definitely check out that episode. We will put a link to it in the show notes. So I just had the best time having that conversation and he also has a really incredible following on Instagram that you can check him out. So that was Dr. Cameron Chestnut. In any case, through him, I met another incredible doctor at his practice, Dr. Christopher Meadows, and we did a call to just like learn more about him and what he does and what he focuses on. And his story is really incredible. We're going to talk about it on today's show. He has a background in actually like college football at UCLA. My, um, not my nemesis, but I went to USC, so it's all good. In any case, he has a really incredible backstory of his sports background and then transitioning into this world of regenerative medicine, rehabilitation, recovery, all the things. And with talking to him, I realized he was so educated and nuanced on the role of fasting in surgery, recovery, health in general. And I just knew that this would be a really epic conversation to, to really talk more and dive deep into that. And I'm sure we won't just talk about that. There's so many things that we can talk about. I have so many notes here, but in any case, Dr. Meadows, thank you so much for being here.

Dr. Christopher Meadows
It's such a pleasure to be here. Thank you so much for the warm introduction. And I'll try not to hold it against you, our alma mater nemesis here.

Melanie Avalon
know, it's all good. I think we talked about this when we talked. What years were you there at UCLA?

Dr. Christopher Meadows
I was there, I graduated in 2009.

Melanie Avalon
That's right, because we think we might have like, because I was there 2009 as a freshman. So I probably saw you, yeah, play, which is wild because like, especially freshman year, that's, you know, like freshman year is like the year you're like really, really invested.

You go to all the games.

Dr. Christopher Meadows
games. Exactly. In the student section.

Melanie Avalon
Yep, in the student section. Oh my goodness, I'm gonna get emotional. It's all good.

So in any case, with that introduction, yeah, where to start. So well, first of all, I would like to start there. Did you always have goals of playing like sports in college? Because that's a big goal.

Dr. Christopher Meadows
Yes, I grew up a huge sports fanatic, athlete, loved playing sports, loved watching sports. And from very early on, I knew that I wanted to play college football. I wanted to go beyond that, play in the NFL. That was my dream. So I knew that from a very young age.

Melanie Avalon
It's so interesting, especially like when if you've like been to college, the college football players, I mean, you guys are like celebrities, you know, like if you're like in a class with one, it's like, oh, so yeah, that's really amazing.

And appropriately enough, though, I'm so I actually interviewed last week, Dr. Heather Sanderson, and she has a book called reversing Alzheimer's. She talked about this holistic approach, she actually published, I think the first study that shows their their lifestyle type interventions actually reversed our reverse cognitive decline, I think. One of the things she talked about was just things that you could do, you know, to support your brain, one of which was sports and movement, but only certain types, and one of which was avoiding sports. So she literally was said, like, don't play football.

Dr. Christopher Meadows
Yeah, the head trauma can certainly be a negative impact. So I mean, it's not a not an easy decision when you're thinking about it.

People ask me all the time because I have two boys and are you going to let your sons play football and right now they're in flag football, which is a growing sport, which is awesome to see and is going to be in the upcoming Olympics. So I'm super excited about that. But oh, it is. Oh, yeah.

Melanie Avalon
Wow, I didn't know that.

Dr. Christopher Meadows
Yeah, so that's a growing sport. And I know in Southern California, it's very popular amongst the youth and much safer environment. Obviously, you're not running and colliding into each other and creating head trauma. So a lot of benefit to that.

So I'm torn on that. We can go into that in more detail in my opinions. But certainly having recurrent head trauma is not beneficial for long term cognitive health. That's for sure.

Melanie Avalon
Yeah. Did you ever have any intense injuries while playing?

Dr. Christopher Meadows
I always joke when I say this and say, I don't remember. But no, fortunately, I kind of stayed safe. I was a coroner when I played college, so I was in the outside and for the most part avoided big collisions that running backs and linebackers play on a regular basis. So I didn't have too many major head traumas, but there's certainly enough there that I'm going to be paying attention to my cognitive health as I get older.

So what happened?

Melanie Avalon
So you did the football, you had thinking of going to the NFL, what transitioned with your career?

Dr. Christopher Meadows
Yeah. So as I started thinking about what I was going to do long-term, of course, I still wanted, you always have to have this vision that you're going to go to the next level, right? If you're not, if you're not actively thinking about how I'm going to get better or how I'm going to kind of try to get to the next level of competition, then you're not really coming with the mentality of competing, right? And so of course, when I was early in my college career, I still had that mindset.

I wanted to go to the NFL, but I started to have more and more conversations about what I'm going to do, you know, from a professional standpoint, what is it you're going to major in and what are you going to do after football is over and thinking realistically about life after. And it's a hard conversation for many of them. You talk with anyone and they all really kind of tunnel visions. Like I don't, what do you mean life after football? What is that? What is that? I don't, I don't know of anything outside of what I'm doing now. That was when, and, you know, along with that, I had a couple injuries and that sidelined me for a bit. And so that's when, you know, things start to hit. You have a little bit of a reality check and say, no, you really need to start putting some thought into this. And I always had interest in health and medicine. I always had this idea that I was going to go into the healthcare field to some degree that I started as physical therapy. I had my, my mindset on that because I had injuries and I was in the physical therapy office and I really liked that environment and helping athletes get back, get back to the field and get better playing. Then unfortunately, I had a shoulder injury that required surgery and I was introduced into a orthopedic surgeon. And that's when I thought, wow, this is really where you want to be. This is the space where you're knowing medicine to its fullest. You're knowing all the ins and outs. You're seeing surgical interventions and getting exposed to the inside of anatomy. And I was just blown away with the surgeon's knowledge and the outcome that I had from my surgery. And so that's when it was determined that medical school was the route for me. And when I made that decision, there's conflict there. There's only so many hours in the day and I could not invest to my athletic skillset as I needed to, to keep up with the competition that was coming in. And so I saw that I was kind of reaching my limit and my peak capacity on the sporting world as I started to put more time and effort into the academics. So there was a challenging time there where I had to come to the realization that my sporting career was coming to an end, at least at the collegiate level. I still maintain my identity as an athlete to some degree and still maintain that pursuit for my general health now. But I knew that I needed to spend more time with my pursuits on the medical side. And so I had my sights set on medical school and that's where we are now.

Melanie Avalon
Wow, so many things. Yeah, I thought about this a lot with the with the whole sport thing and that so I personally, I was never a sport person. I think I like in elementary school, middle school, like I played every sport at least once. I think my dad was convinced if I like, you know, I think he made me play everything at least once because he was hoping I would like like one of them. But I've thought often what you were just talking about, about this identity crisis shift that probably happens because, you know, if you're doing these really grand sports where it becomes your career and your life focus, so football, the Olympics, all the things, then I can't even imagine what it's like for that to just, you know, end for people. So I'm grateful.

I'm grateful that my goals and passions from when I was little weren't things that had a ticking time bomb on, you know, then potentially ending due to like age. I mean, age, I guess, really. Yeah, wow. So kudos to you for the career choice that you made, because that's incredible.

That's no small feat. Are there I have so many questions. So looking back with everything that you've learned, do you approve of some of the rehabilitative work that you experienced when you were a college athlete? Do you shutter at some of it? Would you have done things completely differently? The same? Like, what do you think looking back?

Dr. Christopher Meadows
Yeah, that's a good question. And it's tough to say because medicine is changing so fast. You know, there's newer surgical techniques, there's newer treatment options. You know, we live in a world now where regenerative medicine is at the forefront and that just simply wasn't available at that time. I was fortunate, despite all of the injuries that I had, that none of them were surgical except for the one shoulder surgery that I had. So, you know, I've always had the mindset of trying not to undergo surgery if not needed, taking the more conservative approach. That doesn't mean you're not aggressive from a rehabilitation standpoint. You know, undergoing surgery is a difficult task and it's, you know, it requires its rehabilitation process. And so anyways, I was fortunate that I didn't have any major surgical needs at that point. And so I am happy with the rehabilitation protocols that I underwent at that time.

However, if we were to replay that with what's available now, would I have pursued additional techniques or options? I certainly would have. And so that's just, you know, I would have hoped that that would have given me an opportunity to return to the field faster, recover faster, recover to, you know, instead of being at 80%, be at 90%, 95%. So those are some of the things that could be offered in the regenerative medicine space. But again, it's just simply wasn't available at that time. So I think I was in the right hands with what was available at that time. And, you know, again, medicine is just changing so fast. And that's a good thing. We're getting some newer techniques and newer developments. And that's just the way of the world. Things get better with time.

Melanie Avalon
I'll share a little bit of your bio involving your medical career because it's really intense. So you've served as the associate program director for the St. Luke's Rehabilitation PMNR residency program, clinical assistant professor at the Department of Medical Education and Clinical Sciences at the Elson S. Floyd College of Medicine at Washington State University, and clinical faculty through the University of Washington School of Medicine. And you've also contributed as an author to major medical texts in the field of rehabilitation medicine. So not only are you learning it, you know, practicing, but also, you know, teaching as well, your passion with this work that you do.

How do you feel like when you're teaching about it versus like doing the work in clinic? Like where's, where's your heart? How do you feel when you do those different things?

Dr. Christopher Meadows
Yeah, that's a good question. I've always envisioned myself as a teacher, even with patients, you know, yes, we're diagnosing disease and we're coming up with treatment protocols, but a huge majority of what we're doing with patients is we're educating. We're educating on the background of the disease process. We're educating on what the expectations are moving forward. What are the outcomes with various treatment options that patients are pursuing? So there's always an underlying theme of being a teacher as a physician.

And so that's always been something that I've carried with me and I've had a natural inclination to be able to share knowledge to patients in a genuine way, in a way that's understandable. And that's carried over into the educational side for, you know, learning physicians. So residents, resident physicians who are young physicians that have chosen the specialty in physical medicine and rehab, which is what my specialty is, I've been able to, you know, have the privilege to take them kind of under my wing, so to speak, and to teach them the pearls that I've learned over time. And that includes lecturing, that includes having them in clinic with me and allowing them the exposure of the clinical pearls that I have. And it's just so natural for me to share that with them. And it's fun to see how they develop over time and improve on their skill sets. And when you see light bulbs go off and they start to make these connections and they feel confident in their skill sets, they feel confident in their abilities to take care of patients. I mean, that's such a gratifying experience for me. So I love doing that. So it extends in both, in both realms, both in front of patients and how I'm educating them, which is a unique skill set, but also teaching residents as they grow up to become full blown attendings. And so they're both fun for me.

Melanie Avalon
I love this so much. This is literally what I look for. Honestly, whatever I'm trying to find a doctor for whatever it may be, because I think especially in today's conventional healthcare system, it can often feel very, you know, systemized and like there's not usually a dialogue that easily can happen between the patient and doctor at least in my experience again with like the conventional system. And so what I'm always looking for is a doctor that is, you know, learning and educating and having those conversations. And so this is just the best of both worlds. So thank you.

Before we get into some questions about, you know, surgery and recovery in general, what type of procedures do you actually do?

Dr. Christopher Meadows
Yeah, so my practice is primarily in the orthopedic space. In physical medicine rehab, we train to be experts of the musculoskeletal system as well as the nervous system. And so we learn in detail pathologies of tendon, pathologies of joints, pathologies of nerves. And so within that, you know, again, with my background in the sports medicine world, that was my interest is I wanted to treat patients and athletes to help them recover, help them improve, help them to get back on the field, you know, and recover from injury or even prevent injury.

So a majority of the patients that I see are coming to me with joint related concerns, tendon related injuries, whether acute or overuse injuries. And so in my practice, I do a lot of diagnostic ultrasound that is really key for my evaluation process because it allows me to see the structures underneath and no radiation involved, no real significant side effect profile. So I can just at the bedside see what's going on with muscle, see what's going on with tendons and joints. And from there, make really clear diagnoses to whatever issues are going on. And so if we do find a pathology, then we can talk about treatment options, which are primarily peripheral joint injections or tendon injections. And so this is where we get into what's available regarding regenerative treatment approaches, including things like PRP, PRF, stem cells. And so the majority of treatments that I offer are bedside ultrasound guided injections to areas of pathology to stimulate regenerative capacity.

Melanie Avalon
Awesome. And then would you ever do surgery or refer out for surgery?

Dr. Christopher Meadows
Yeah, so I'm not a surgeon myself, so I can refer out to surgeons if that's needed.

Melanie Avalon
Awesome. So okay, big question here, because I feel like there's two, you know, two big camps of, and this is me not, I mean, you're doing this every day, so I might be wrong with these camps, but I would envision there's like two big camps of people, people who, you know, have a recent injury and, you know, they know it caused it and it's fresh, it needs to be addressed.

And then these people with chronic injuries, you know, like shoulder pain that never went away or whatever it may be, is there a different, do you have a different approach to addressing something that happened more recently compared to something that somebody's been struggling with for a long time?

Dr. Christopher Meadows
Yeah, that's such a good question. And you're absolutely right. These are different pathologies, there's different mechanisms of injury that result from these different scenarios that you describe. So in an acute injury, you have usually a trauma or you have, you know, some sort of abnormal position that a person was placed in. Oftentimes we're talking about in an athletic competition, you know, there's a mechanism of injury that you can see clearly caused an injury.

And that is vastly different from a chronic overuse injury. So use the example of shoulder pain, an individual who's had shoulder pain, maybe 15 years, 20 years, maybe has had a couple of acute issues there where they fell on it or something, but never really had any significant trauma that required surgery or anything. And so it's been a long time of just recurrent injury pain that's never really gone away. Maybe you've tried therapy here and there, and it's just lingered. So that type of progression is dramatically different. If you look at these different types of pathologies under a microscope, you would see totally different types of immune responses. You would see different types of changes to tendon or to cartilage. And so certainly you would not want to have the same approach because they're completely different. And how you address that, how you choose to utilize whatever your treatment protocols are, are going to be very different in those two circumstances.

Melanie Avalon
For the chronic example, have you found when you do your investigation or ultrasound, you know, you isolate what the problem may be. How much of it is a one-to-one for you can see the problem and that correlates to what the person is experiencing versus how much can be, I don't want to say in their head, but you know, we have this concept of like phantom pain or, you know, people who will ongoing injuries, but when you actually look at it, it might not signify that that would be what they're experiencing. Like, so how is it usually like you see the problem and it's pretty obvious or is it sometimes not?

Dr. Christopher Meadows
Yeah, that's a good question. And that's that's the challenge to the clinician is in particular when I'm doing diagnostic ultrasound, oftentimes, I'm finding lots of pathology, I'm seeing lots of different areas of abnormality. And the trick is to say, well, which one of these is actually causing the pain. And that's one of the nice things about ultrasound is that I can just do this at the bedside.

And I can actually have you move and I can say, well, why don't you show me what causes the pain and I can see it immediately under ultrasound and find that oh, this bursal gets all punched up, pinched up, and it gets, you know, inflamed, I can see it bulging out under certain movements. And so you get both ends of those spectrums where on the one hand, there's multiple abnormalities, and I have to figure out which one it is. And on the other end, you say, wow, well, this is a relatively normal exam, I'm not seeing anything, and trying to tease out, you know, how much of this is, you know, inorganic versus something that's made, you know, come from somewhere else. And you mentioned phantom and oftentimes, I don't run into too much phantom pain, but I do run into referred pain, which is pain that can be kind of your nervous system is designed to sense pain and tell you, hey, that's coming from this location. But when it comes to and that's, that's easily recognizable on your fingertips or something that has a high sensitive high nerve innervation ratio. But you know, your joints can be particularly difficult to really pin down, you know, oftentimes says, well, my whole knee hurts, it just kind of hurts everywhere. And that's where things get a little bit more challenging. But again, when you can see things under ultrasound that does help you, it is challenging when you say, or when you have a case that you just don't see any abnormality and trying to pin out, well, what is it exactly that's going on in those require a little bit more workup. But that is the challenge for the clinician to, you know, go through a thorough physical exam and a thorough diagnostic ultrasound to really find that and I find myself on the opposite end of that spectrum more often than not, which is I'm finding multiple areas of abnormality. So which one is it that we think is actually causing your pain?

Melanie Avalon
Interesting. So, you know, some areas are, like you said, are abnormal, but they actually might not, but they're not causing symptoms. Correct.

With those types of things, is it fine to just, like, let that go then? The ones that aren't causing symptoms?

Dr. Christopher Meadows
Yeah, you don't want to over-treat and you don't want to diagnose pathology or create diagnoses that aren't there. I don't want to make bigger issues than they are.

At the end of the day, when we think about pain and function limitations, those are really the areas that patients, I want to feel better, I want to be free of pain, and I want to be able to do XYZ, right? And so that's what I'm here to do, is help you get back to functioning or get back to your exercise regimen or get back to playing with your kids, whatever it is that you have interest in doing that you're being limited because of this pain, that's ultimately the goal. And so if I go and treat other areas that aren't bothering you or are not pain limiting, then we're not really achieving a whole lot. Now you could argue on the other side, and I do see this, where patients would say, well, why don't we just treat that from a preventative standpoint? And so we have to have those conversations on what to expect, what are our expectations in doing a preventative treatment approach? And so that's also a different conversation and a different regenerative mentality to think about when we're just doing preventative treatment as opposed to treating something that's abnormal and trying to get us back to function and reduce pain. So there's just different buckets of patient populations and different approaches to take in those circumstances.

Melanie Avalon
Yeah, I can totally see, especially in the biohacking community, you know, like for me, for example, if I were to see all the things, I'd be like, Oh, I will. Well, I want to fix all the things.

I've had an interesting experience because I have like a tight shoulder knot that is kind of always there. And I also get kind of, I get not too much pain, but tension and some issues, but it's all on the right side of my body. And every time I've had any sort of scan done by whoever is, you know, analyzing it, they've always told me the problem, same with like my mouth, like I have TMJ issues on my right side, I'm always told the issue is actually on the left side. And so that it's, and so that's what one of the reasons I've been so intrigued by, you know, the experience of the pain versus where it's actually coming from, because that always blows my mind when they told me that about things.

Dr. Christopher Meadows
Yeah, that's such a that's such a good point.

And then on the other side of that is, you know, when it comes to imaging and when you say you've had imaging, are you talking about ultrasound or x rays or MRIs or all of the above?

Melanie Avalon
So I've had MRIs, X-rays, I don't know if I've had ultrasound, definitely X-rays and an MRI.

Dr. Christopher Meadows
Yeah. And these are the things that we always talk about, you know, when I'm working with residents and doing some teaching, we have to be cautious on two fronts when it comes to imaging and these, you know, advanced imaging like MRI, they're static positions, you know, and oftentimes not normal positions, you're lying down and, you know, sitting there for 45 minutes while the magnet is spinning around you.

And it's oftentimes, you know, you wonder, well, what happens if we were to change positions, because there's always this standard position to be in, we think about that all the time when it comes to low back pain or neck pain, and we do an MRI of the spine. And you say, well, this person is laying down what happens when they flex forward? Or what happens when they side bend? And what kind of changes are you going to see in these different positions that could show more of what's going on? But again, going back to my previous topic about not over diagnosing things, you can't call every pathology that you see, there's a certain range of normal, right? And you say, okay, well, this disc is a little bit big here, or this disc height is a little bit, you know, small here, you have to really be a clinician and think about what is actually outside of our range of normal, and what is it that's truly causing this pain and discomfort. And so when you say, well, I have pain on the right side, but they always say it's the left side that bothers me, that doesn't mean you go and start treating the left side, you can, you know, focus on the side that's giving you problem, maybe you look somewhere else.

Melanie Avalon
Yeah, this is it's so fascinating to me. Quick question, because I actually appropriate timing. Yesterday, I got back a lot of data from a genetic sequencing. Actually, they're called sequencing was the company. And it generated all of these different reports for my, like my genetic tendency for different disease risk categories. And I was pretty much in the clear for most things, with some exceptions.

And one was which I, my, my mom has really experienced actually a lot of people in my family have had issues with arthritis, that type of pain. I came back like in the red for all of that, which I found was really interesting. So my question, I have not experienced that I'm aware of any arthritis pain to the at this point. But the role of genetics and epigenetics in any given situation. So when you when you see a person, like, like, how much do you look at their genetic data? Does it even matter their genetic data because of the power of epigenetics? How do you feel about the role of genetics and pain?

Dr. Christopher Meadows
Yeah, that's a good question. And genetics can certainly be an additional piece of information that can help guide you. And that could be in a circumstance, well, we see all these pathologies and we know what your genetic profile is, maybe it does make sense for us to be more aggressive and talk about what sort of procedures would be helpful or exercise routine or dietary approaches. So I don't do that standard with most of my patients.

If we do have, you know, you get a history and you talk with patients about what's going on, like you mentioned, you have a family history of arthritis. So going into that history can help to say, you know, maybe we should explore this a little bit more or you have patients that have recurrent injuries and you think, gosh, well, why is it that you're, you know, you're back again and now it's your left shoulder and we've already treated both knees and the right shoulder and now you start to kind of, you know, raise your eyebrows as to is there anything else going on? And you might think about doing some genetic testing to see, you know, a lot of those things give some good information and can certainly be additional pieces of information to maybe augment your approach and, and think about being a little bit more aggressive from a preventative standpoint, both from a treatment and preventative standpoint. So those are certainly helpful. We do that with a part of our practice is functional medicine where we do that, you know, more routinely for all of those patients. It's not routine for my patients with the exception of these circumstances that we think, gosh, we need to do a little bit more investigation to see if there's something underlying.

Melanie Avalon
Gotcha. Okay. Yeah. Yeah. I was like, when I got the report back, I was like, well, that makes sense based on what I know from my family history. And still, like, I don't ever want to feel destined by my genes that, you know, I'm going to manifest a certain condition because I think people have so much agency, you know, with what they with their lifestyle.

So when you're working with, you know, this population with pain, what is the role? So you mentioned like, you know, different types of injections, and we can definitely talk about those. And also at the same time, what is the role of the lifestyle that the patient is following? Is there, does that majorly affect either way, the effectiveness of the treatments that you're doing?

Dr. Christopher Meadows
Yeah, that's a good question. And this goes to my approach regarding treatment of patients, which is not a single modality. I just don't think of treatment with patients as a single modality, one size fits all type of approach.

And you mentioned earlier the introduction regarding Dr. Chestnut's approach to recovery, which is this multifaceted, you know, post pre and post-operative rehabilitation or recovery. And I think the same in my space on the rehabilitation side that a procedure is one piece of the puzzle. It's also thinking about your biomechanics and how you're moving. What made you susceptible to this injury? And what is it that we can augment in other areas from a nutritional standpoint or from an exercise regimen standpoint? Now, not every patient is really interested in going into that much detail or that much depth for their recovery, but those that are receptive and really want to approach this from a multifaceted approach and thinking about all of these additional areas, then that's when we can really have good conversation regarding, well, I'm going to do a procedure. I think this is going to help. But if we also do this exercise regimen on top of that, particularly when the first, you know, handful of days after a procedure where things are inflamed, but I want to keep things circulating. I want to keep muscles active. I want to keep tension on the tendons. All of those things are going to help in the efficacy of your treatment, regardless of what it is, whether we choose to do a PRP or a stem cell injection. They're going to support and augment your recovery process to help things not only recover faster, but allow for the full efficacy, the full potential of the treatments that we're doing. So I do have those conversations with my patients regularly.

Melanie Avalon
And so you actually touched on something I had a big question about. So you mentioned, you know, this inflammatory state that people can be in. What is the role? I'm very haunted by this actually.

So I think people are pretty familiar with the idea of acute versus chronic inflammation and you know how acute inflammation is actually in theory, a healing process. Like it has a purpose there compared to chronic where it's just not going away and it's creating more damage in that initial injury phase where there's inflammation or even like inflammation, post-surgery, whatever it may be. What is the role of like reducing and suppressing that inflammation versus letting it play out? Like, do you need that inflammation?

Dr. Christopher Meadows
Yeah, that's such a good question. And my perspective is that we do want that inflammation when we acutely injure something. You know, you say you're walking, you sprain your ankle, for example, and it gets swollen, it gets red and hot and uncomfortable. The pain sensitization goes up, so you're more sensitive to any stimuli. And that's part of the initial inflammatory phase. And this is part of the healing cascade. And you want it to naturally transition from that inflammatory phase into the proliferative phase and the remodeling phase. Those are your phases of wound healing. And you want it to do that.

And there's, when I was in medical school, actually, we had a lot of conversations regarding acute fractures and what's the role of anti inflammatory, specifically NSAIDs, which is like your ibuprofen, your Aleve, your aspirins, those sorts of medications, which are intended, they're anti-inflammatories, they go in and they block the inflammatory response. And you will feel better, it reduces the pain, it reduces the swelling. But what impact, what potential negative impact does it have by skipping the steps to go through the rest of the wound healing cascade? And so I still maintain that approach. I'm not a big fan of utilizing anti-inflammatories in the acute phase. We can talk about the post procedural approach that I have as well. But the natural cascade of the inflammatory process that peaks after an acute injury and is allowed to go through its full progression will allow for the maximal amount of healing that is necessary for that area. Now, if we have recurrent trauma, or we get back to play or sport too soon, and we now have recurrent injury, and a now low grade inflammatory response, and it swells up again, and we have more pain, and whenever I do this, it really swells up and starts to bug me. You know, those are those are signs that we've not allowed for full healing, we've not allowed this to to fully recover. And so we need to be more aggressive with our rehabilitation, we need to maybe scale back on the activity, we need to scale back on the intensity of exercise or what have you. And we want that inflammatory phase to fully subside to fully come down and allow maximal healing before we start to put in more stresses. But so again, I am against I am against the idea of trying to blunt that response just to allow for improvement in symptoms.

Melanie Avalon
And what about so you're talking in the role of, you know, like pharmacological insets and things, what about if people were to do, you know, high dose, I don't know, turmeric, and, you know, omega threes and cold exposure, what about those ways of doing, you know, creating an anti inflammatory response during the inflammatory phase?

Dr. Christopher Meadows
Yeah, that's a good question and that kind of stems from where the inflammation is coming. I think when people are doing those, they're talking about systemic inflammation and what's going on, you know, full body cardiovascular health, overall metabolic health. And I think those are great for that type of inflammatory response, the systemic. Those are also great when we have infection or wounds and they can help to reduce the inflammation. What's nice about those is they don't blunt the inflammatory response in the same way.

When we talk about NSAIDs, we're talking about direct implication or direct inhibition of specific cellular mechanisms of the wound healing response, so specifically platelets, which are the main responder in that inflammatory phase. And so when we have medications that are going after and inhibiting them directly, then, you know, that can have a negative implication moving forward. But when it comes to these more, you know, herbal remedies, the turmeric, those sorts of supplements that we're taking, they don't have the direct inhibitory response that you see with these sorts of pharmacologic approaches. So they're not as negatively impactful. They do not blunt the immune response in the same manner. They do not impact the wound cascade in the same manner. So I don't see any reason with having to worry about taking those in the acute phase and they can potentially support that inflammatory process as well.

Melanie Avalon
Awesome. Okay.

And I don't know if this is specifically in your wheelhouse, but it's a question that I have all the time and I actually had today and it kind of relates, so I'll just go ahead and ask it. So I often will do M-sculpt for like muscle building, and I usually do like a cryotherapy session right after. Do you have thoughts on the post, you know, strength training session doing anti-inflammatory type things? Does that hinder muscle growth? And this is a tangent question, but I don't know if you have thoughts on that.

Dr. Christopher Meadows
Yeah, that's a good question. I mean, same similar process, right? When we think about an exercise regimen, we are, again, causing an acute inflammatory response. Now, it's not as robust as the ankle sprain example that I gave earlier, but it is still causing muscle damage.

You're having tissue and tendon injury that is of lower grade and is creating a stimulus for remodeling such that we can get stronger, right? Muscular hypertrophy and tendon strength. When it comes to, there's good literature out there regarding the blunting effects that cold plunge can have after strength or cold therapy can have after strength training with specific to the hypertrophy and strength gains. So that's out there. When it comes to body composition, I think there's less impact that that has from a negative standpoint. It's not going to impact that as much, but we know that the cold exposure can blunt that strength force development and hypertrophy effects. So that is something to think about, but it's not hugely robust and it's not a big thing to worry too much about, but it can.

Melanie Avalon
There's basically from what I've seen, there's just enough studies to make me like nervous about it, you know, okay, that that all that all makes sense. Also, while we're existing in the the lifestyle realm.

So fasting and this is something you and I talked about, talked about on the phone and something that I get questions all the time about. So what do you see the role of fasting so intermittent fasting on people's, I guess, inflammatory state pain state, and in particular, recovery from injuries, surgery, I can ask more specific questions, but in general, just fasting. Is that something that you recommend to patients that you like? What are your thoughts on it?

Dr. Christopher Meadows
Yeah, I'm a huge fan of fasting. I do it personally for primarily for metabolic support. So that's where I really got introduced into fasting and its potential for, you know, supporting insulin sensitivity, supporting cardiovascular disease, blood pressure, lowering, etc, etc. So that's my introduction to fasting was in that realm.

But what's been fun to see is how that's really carried over into the regenerative medicine space where fasting has been shown to support stem cell health, support stem cell number and regenerative capacity. And so, you know, talking with patients, again, if they have interest in pursuing this, fasting is a great potential additional tool that you can use to help regenerate. And in my space with doing peripheral joint injections or tendon injections, the recovery state like the, you know, caloric requirements post procedural is not significantly high. And if you can add a fasting, you know, a period of time of fasting after procedure, it can certainly help with that regenerative process. So we do talk about that with patients. Again, we have we have a variety of patients and their perspectives and their interest in doing that. But it's also well known that if we support the metabolic health of patients that their regenerative capacity is going to improve. So when we say, well, your fasting is not only going to support the recovery from this process, but from a general health perspective, your stem cells are going to be more effective, you're going to have more numbers of them. And they're going to be the capacity for regeneration is going to be higher and support you for the recovery of this injury, but also the prevention of future injuries and risks of future injuries. It's a great tool to use, obviously, it's low cost, and it's not a significant burden to anybody outside of the discomfort that you have when you're fasting. And you know, you can you can scale that back and have a different duration of time for which you do undergo a fasting window. But it is a great tool to use and use it regularly with my patients for the recovery and regeneration aspect.

Melanie Avalon
Awesome and something you said in there is like the question that we get from people which is you mentioned if the caloric needs or the you know protein needs I'm not sure I think you said caloric needs aren't too high. How can people know if they're in that state or not with it like a surgery in particular?

Dr. Christopher Meadows
Yeah, and that's where things get a little bit more challenging when you think about surgical states because these are more intense, you know, if you have a surgery, the catabolic aspect of that is so high and you really want to ensure that you have good caloric supplementation to meet the anabolic aspect of it that comes after the surgery. And so your surgeries are generally listed as mild, moderate to severe when we think about risk of perioperative surgical interventions. So that's one tool that you can use, but the duration of the surgery along with the location of the surgery can be a big factor to help you decide whether or not you want to embark on a fasting. Of course, you would want to talk with your surgeon to see. It's not uncommon, of course, as you know, you would be fasted going into the surgery, right? You're usually not eating by midnight the night before of a surgery. So you do go into your surgery, you know, varying degrees of having a fasted state. If you're eight in the morning, not as much, but maybe you have a 3 p.m. surgery and so you're fasted for a little bit longer. And if it's a pretty major surgery, they might keep you without eating until you have movement of bowels and you're starting to pass gas. And that's the typical kind of thought process around almost all surgeries.

But when you have things that are intra-abdominal or intra-thoracic, you're really getting into these large surgeries that fasting is probably not going to be a beneficial approach for you to take. Once you can start eating, you really want that caloric supplementation to help the recovery process and the protein supplementation, as you mentioned. So those are big aspects of the healing cascade that you want to make sure you're not limiting your body in addition to the micronutrient demand that you will have at that time. You know, zinc and magnesium, all of these micronutrients that you want to make sure you have in, you know, an abundance so that you can maximize your recovery. But it also is not uncommon for patients to fast in advance of a surgery to be going into it in a slightly fasted state. And the idea around that is having higher levels of ketones, which ketone bodies can be great for recovery as well. But as far as knowing what threshold, there's not a clear line of what the threshold is for what type of surgery, but those would be the considerations. If it's something intra-abdominal, if it's something intra-thoracic, the duration of surgery, those are going to be things that are going to help determine whether or not you would want to have a perioperative fasted state. If it's something that's really relatively minor, that maybe is on the periphery or cosmetic, that might be a better option to seek a fasted state in, you know, pre- or post-surgical.

Melanie Avalon
Actually, and a question related to that because you're, you know, you're talking about speaking with your surgeon about, you know, what is the best approach for people to implement with fasting and, you know, that lifestyle. We actually got a question, it kind of relates, what can people do?

This is not the question, I'll read the question, but if people are having a surgical procedure done, again, in the conventional medical system, what can they do to know how to appropriately integrate different recovery methods. So be it fasting, be it more regenerative things like that that we can talk about, but I'll read this question that will kind of like illuminate what I'm saying. So Macy, for example, she said, I literally had surgery yesterday and the biggest struggle has been finding out what works for post surgery protocols. My doctor who's totally supportive didn't feel comfortable with giving me timeframes for PEMF or red light therapy. It's a fine line to want to utilize all the tools at your disposal, but also not wanting to negatively impact recovery. So I can see this situation probably being pretty common for people because, you know, not everybody is always getting these procedures done with, you know, somebody like your practices approach. So how can people know like what they can be doing on their own to help their recovery in the more regenerative sphere?

Dr. Christopher Meadows
Yeah, that's such a good question. And I think it's difficult to say where patients can, you know, it's hard to make blanket statements to say, this is what you can do.

I mean, this is what I run into in my practice quite regularly, actually. It was where patients are having surgery and they're saying, what can I do to support my surgery, my recovery? What can I do in the weeks leading up to my surgery? What can I do post-operatively? And it is really unique to the specific surgery and, you know, what was intervened on to know what is gonna be safe and effective. For the most part, I mean, thinking about, and it's not, you know, again, seeing doctors that just don't have as much knowledge in this space kind of be uncomfortable. And so I do talk with patients about that who we would do consults with and say, here's what's gonna be great. And then having the collaborative conversation with the surgeon, if we need to, to say, here's what I'm thinking, this is what I would do, and here's what our potential side effect profile is gonna be. And most of these are really low risk when you think about PEMF and red light therapy, you know, again, depending on the location of the surgical incision and what it looks like. The one that really requires a little bit more knowledge around is gonna be hyperbaric because of the pressure involved. And so when you're thinking about intrathoracic surgery, you know, I had a recent patient who had a resection of a portion of the lung, and you know, you certainly would not want to increase intrathoracic pressure by putting in patient in a hyperbaric and you can run into some problems there. So that's one that you would certainly wanna look out for. But for the most part, there's not a whole lot of risk, but these are conversations that I would advise to speak with a provider who's knowledgeable in this space. And if there are any questions that come up, you know, they can contact the surgeon and they can have that dialogue as far as what would make the most sense. And it goes beyond some of those modalities, right? It's also nutrition and supplementation and medications, postoperatively, pain control, bowel support, hydration status, I mean, all of those things are factors that you wanna think about.

Melanie Avalon
Awesome, awesome. Yeah, I think it's, it can be hard for people, especially because if people are wanting to use like insurance and it can be hard to find like the dream, you know, doctor who can do the surgery and also be really knowledgeable on all of these more holistic approaches that people can be doing.

So going back to what you were saying you do a lot of in your clinic with the injections, you said, is it stem cells, exosomes? What type? Is it actually stem cells?

Dr. Christopher Meadows
We do stem cells, exosomes, PRP, PRF.

Melanie Avalon
So what's the latest on the stem cell legality situation?

Dr. Christopher Meadows
That's a good question. You know, this language around whether or not stem cells are legal or illegal I think is not really the right verbiage.

There are FDA approved pathways to utilize stem cell products and they are available here in the United States. You don't have to travel abroad to get stem cell products. But you know, there are certain requirements and tissue handling and tissue, you know, practices that need to be utilized that's overseen by the FDA. And as long as you're following suit and following those guidelines, you're well within the means to utilize stem cell products, exosome products for tissue repair for treating patients.

Melanie Avalon
And what do you see the timeline of healing or resolving of pain with these approaches? So I actually, I've had one stem cell treatment. I did something to my knee, I guess in like 2021 maybe. And the pain just, it was really bad at the beginning. And then it was just kind of chronic, like it would act up, especially if I wore heels or it just always, yeah, it would act up essentially.

And I got a stem cell injection like directly into it. And the thing that's hard for me to gauge is I can confidently say now that it's gone. Like it doesn't flare up. I don't feel it anymore. But it's hard for me to know if it would have been gone anyways because of the time.

Dr. Christopher Meadows
That's so good, yeah, you're exactly right and so I guess your question is like what is the expected timeframe for resolution of pain or symptoms for some of these issues and certainly it depends primarily on what the initial injury or what the pathology is. As we talked about earlier, in acute injury, you sprain your ankle, I'm expecting that to get better with time as long as we give it the right environment and we can try to augment that to speed it up but as we've all experienced, you get an acute injury and hopefully that heals well with time.

Then on the other end of the spectrum, you may have an injury or something just kind of gradually starts to bother you and before you know it, it's been a couple years and you try some therapy, it doesn't work and now it's five years and it just keeps lingering and you kind of try to do some measures but nothing seems to be working and those are where it gets a little bit more complicated because when you run into these degenerative conditions, you know we talked about arthritis earlier, these are conditions where the cartilage is starting to wear down, the tendon is getting a little bit more frayed and thick and tender and these types of injuries are really the ones that are more challenging to deal with and it's no secret that there hasn't been and you mentioned the traditional healthcare space, there have not been great tools to try to help these conditions. We have steroid which is great, again just like the anti-inflammatories, it's going to reduce the inflammation, it's going to reduce pain and you're going to feel great but it offers no regenerative capacity and it does not allow for, it certainly doesn't offer anything from a regenerative standpoint.

So when we think about how we're going to approach these chronic conditions, we have to say, you know this is a little bit more, it's going to take a little bit more time to reduce the pain and to improve function and it's not the same approach that has historically been where I'm going to reduce pain and you're going to feel better tomorrow. No, this is going to take some time, we're going to have to invest into this a little bit again thinking about all of the multifactorial ways in which we can approach this, lifestyle intervention, etc.

But when you look at the research out there around different regenerative products, the outcomes seem to peak around six months. So it's again, it's not a quick fix, it's something that takes time.

And when you look back historically at these patients that have been suffering with pain for five years, ten years, when they have improvement in symptoms immediately after, not immediately but you know three to six months after a procedure, you can directly correlate that to the procedure that was done because most of the time these patients have tried everything that's available and have not had sustained relief. And now the studies are going out to three years, five years and even seven years where you're seeing that persistence of pain reduction and improvement in function.

Dr. Christopher Meadows
So you're starting to see the long-term benefits of these as well.

So that's what's exciting about this because it's allowing for long-term healing, long-term pain reduction, long-term improvement in function and not just the quick pain relief that is seen or the alternative being a surgical intervention, you're not seeing that same sort of potential and healing in those spaces that you are with the regenerative techniques that we have.

Melanie Avalon
Actually, so hearing all that, that's really, you've really got me thinking because like with my injury experience, it was, it was probably a probably a year of the chronic, you know, flaring pain, and then doing the stem cell. And then, you know, six months later, it basically being gone, but also not knowing if it would have been gone either way.

But I actually just pulled up, I totally forgot about this, we did do a scan of my knee. And they saw because you when this was when you mentioned like the cartilage going away, they meant they saw that that was degenerating where the injury was. I just looked at my, I mentioned earlier the genetic, you know, tendency for arthritis, and it segments it into knee arthritis, hip arthritis and wrist arthritis, and knee arthritis is the one I have like a super high risk for. So I'm just thinking about it retroactively. And I feel like I got that injury, it looks like genetically, I'm very prone to knee arthritis, and I was definitely headed in that direction. And then I mean, if I don't experience it at all anymore, I should get a, well, I don't know what the radiation of that, I would be curious if the cartilage has changed or reversed.

Dr. Christopher Meadows
Yeah, that would be interesting and that's where things are really starting to get exciting from the regenerative medicine space because like I said, when we look at outcomes, a majority of the outcomes, the ones that we really care about is if I can improve your pain and improve your function, right? Because that allows you to live the life you want.

Now secondarily, there are studies out there that look at pre and post ultrasound or pre and post MRI, which is what you're referring to is like what would happen if I repeated the MRI? Would there be any significant change in the thickness of that cartilage that was noted earlier? And studies are showing that, that there's improvement in cartilage thickness and where there were cartilage lesions, they're resolved and that's where things are really exciting and that again shows you the potential, the power that these treatments have and again contrast that with a corticosteroid injection, which can actually be catabolic and actually worsen some of the cartilage that you have there.

So that would be interesting. If it's an MRI, it wouldn't be any significant radiation, actually zero radiation because it's just an MRI. So it's magnetic, it's not the radiation that you experience with the CT or X-rays. So if you wanted to do that, you should feel comfortable doing that.

Melanie Avalon
I wonder, because the initial scan I got, I got at the Urgent Care, would those type of places have an MRI machine?

Dr. Christopher Meadows
No, they're usually CT scanners or x-rays, yeah.

Melanie Avalon
Yeah, so I'm actually I'm very curious now. Okay.

And then for listeners, I will put a link in the show notes. I've done a few episodes entirely just on stem cells. And it's so fascinating the the healing potential with those. Do you do them like for yourself to yourself?

Dr. Christopher Meadows
Yes, I've had, oh my gosh, so I've had knee injuries, you know, these are the injuries that put me in the physical therapy office and that stimulated my medical career, but I've had MCL and meniscal injuries on both sides. I'm dealing with a meniscal injury on my left side that fortunately for me doesn't cause any significant pain or, you know, functional limitations.

So I'm fortunate on that front, but I am very active in trying to prevent that from giving me any problems in the future.

Melanie Avalon
Awesome, and do you find the patient success rate, does it work for most people? Some people, does it not?

Dr. Christopher Meadows
Yeah, we're getting good results. Our patients are regularly coming to us and saying how they've improved. So again, but it's not immediate. We have to give it time.

We have to invest into it. And you have to be proactive in supporting your stem cell therapy with all of the other additional factors. And so that's where we get the best outcomes. But it does take time. Patients usually don't experience anything in the first couple weeks. You're kind of thinking, okay, not seeing a whole lot, but just things gradually improve with time. And I have a unique approach to the way I deliver stem cells, partnering it with PRP and kind of leading up again to kind of improve the environment for which stem cells are introduced. But in looking back patients, we have a really good success rate with stem cell therapy across the board. We treat a lot of knees. You mentioned that knee osteoarthritis is probably the number one condition we see. And it responds very well to stem cell therapy.

Melanie Avalon
Wow, okay. And I'm looking at the recommendations for the knee arthritis in the in my genetic report and it's telling me not to wear high heels which are like my favorite thing.

Dr. Christopher Meadows
That's a challenge.

Melanie Avalon
I know. Do you work with a lot of women, men, like the population? Yeah, both, both. Do you tell the women not to wear high heels?

Dr. Christopher Meadows
You know, unfortunately, that is a challenging one. Sometimes it's knee and sometimes it's ankle foot, you know, they can really start to cause some discomfort of the foot. Obviously, footwear is important. You know, we have to choose our battles and we all have our, you know, vices.

So, you know, it's not that I'm trying to change anybody's appearance or try to change people's lifestyle, you know, you're doing the best you can. And we have to make there's a give and take there, you know, so I try to meet patients where they're at and say, you know, if this is what you want, we just have to acknowledge that these are the potential. Consequences of that and, you know, patients are reasonable and they say, you know, okay, I can expect them. I can accept that this is might not be the best thing for me, but I'm willing to make that sacrifice and address, you know, deal with the consequences after that. And that's fair.

Melanie Avalon
Yeah, I feel like my approach, you know, if I was in a position where I was wearing them every single day, I think I would definitely want to rethink that. I typically just go out like once a week though.

So I feel like the happiness that I get from wearing the high heels, you know, brings some benefit to my life. So.

Dr. Christopher Meadows
Yeah, absolutely. Yeah, and those are the exactly those are the give and take that we give so that's that's that's okay

Melanie Avalon
Also, another question, actually, no, really quickly, so the PRP, what layer does that add to it?

Dr. Christopher Meadows
So, the thing about, let's take knee osteoarthritis, for example, this is a great example of a space that is a chronic inflammatory state. If you sample the synovium of arthritic knees, the pH is low, so it's an acidic environment. It has a lot of cytokines that are pro-inflammatory, so these are signaling molecules that are continuing to stimulate that inflammatory response that we talked about, right? This low-grade inflammation that's persistent, it's not getting better, it's not going away.

Things like interferon gamma and TNF alpha, and these things are pro-inflammatory, and they're immediately toxic to stem cells. And so, when I think about treating a patient and I want to do a stem cell injection, if I want to get the maximal benefit from those stem cells, I don't want to put them in an environment to be interfered with from an inflammatory and low pH environment that's going to, you know, they have enough to deal with, I don't want to make an, I don't want to introduce them to an environment that makes their job difficult and can actually be toxic to them. And so, by prepping the joint, by utilizing PRP in a series of injections, I can actually reduce the inflammation in that joint because we know that PRP, which stands for platelet skin, and reduce some of that inflammation and improve the pH, reduce some of those inflammatory cytokines, and that helps to prepare the joint to receive a stem cell injection so that the stem cells can go to the area to regenerate tissue, right? And so, I utilize this regularly with my patients where we'll do a series of one, two, sometimes three PRP injections until we feel like we were able to calm the joint down. We can reduce some of the swelling, the swelling that may have been recurrent previously is now calmed down, and now we can introduce a stem cell to allow them to go to the sites of injury, to the sites of damage, and just focus all of their efforts into that space rather than having to overcome a toxic environment. So, that's how I use PRP and or PRF, you know, platelet-rich plasma versus platelet-rich fibrin, those are things that I use in advance of a stem cell therapy to really maximize the potential benefit of a stem cell injection.

Melanie Avalon
Okay, so is it basically getting rid of the distracting inflammatory signaling that might occur and then just going to the inflammatory signaling that needs to be addressed?

Dr. Christopher Meadows
Yeah, exactly. So the stem cells can go to areas of damaged tissue, and it's not just the inflammation that signals, but it's the damage, the sites of the areas that are exposed that should not be exposed, and the stem cells can see that, and they can go to those areas to stimulate the regenerative process. But if it's an inflammatory state that's just widespread and throughout, again, that is just directly toxic to the stem cells. So if you get X number of stem cells injected, you can reduce that by 50% almost immediately because of the toxic environment that you've been introduced into.

So your army is not as big, and the potential is not as great.

Melanie Avalon
Gotcha, that completely makes sense because I guess, ironically, you wouldn't want to get rid of all the inflammation because then the stem cells, you know, wouldn't necessarily go anywhere potentially. So, okay, very, very cool.

Actually, so another question, just looking more at your bio because you, so you currently do training with Olympic lifting and racing triathlons?

Dr. Christopher Meadows
Yeah, I try. As I mentioned, I try to maintain my identity as an athlete. My focus has shifted from being in college where it was all about performance on the field and trying to be fast, jump high and explosive and that sort of deal. Now it's been to the whole health and wellness side where I'm focusing on what are the metrics that are going to help me be healthy and live long. There's a period of time where I was freshly out of college and the only workouts I knew how to do were the ones that I had been doing in college for the last four years. I didn't really have a focus. It's like, what is my purpose of trying to rep 225 pounds? Yes, there's a strength component and a muscular endurance component, but it wasn't until later that I started to realize that there are markers of longevity and there are objective measures and things that I should really focus in on. It was great for me because now I had a framework to work with. I knew what the new metrics were that I can hone in after to support my health and longevity. That's my focus of training now.

That does overlap a bit. I do some power training still because I want to maintain explosiveness and type 2 fiber, density. Those are the things that I continue to implement in my workout regimen, but also recognizing I was never a long distance athlete at all ever in my life. Football plays are measured in seconds. Thinking about doing a 5K or 10K or triathlon was never really on my radar, but I recognize that there's health benefits from that, from doing sustained long endurance training. I got into doing some triathlons and I've done a couple marathons in my life. I've learned the importance and recognized the importance of implementing that into my exercise regimen, so I try to cover both ends of those spectrums. Again, just thinking about longevity and just overall health.

Melanie Avalon
Awesome. Well, I'm the same in that I lean more towards power, not endurance.

And actually, my genetic test also said that I was on the power side of things. So doing all with all this training, because you mentioned earlier that you personally practice intermittent fasting, what type of fasting window do you do?

Dr. Christopher Meadows
Yeah, so I do once a week I do a 24 hour fast and then quarterly I do a 72 hour fast water only.

Melanie Avalon
Okay, with that once a week, 24 hour fast, is there any specific rules or how do you time it around your athletic endeavors?

Dr. Christopher Meadows
Yeah, so it's on my day off. I usually do my last meal Friday night and then won't eat again until Saturday night and I don't typically work out on Saturday. So that's what I do.

Sometimes I will change, because breakfast is my favorite meal, I will change to eat breakfast on Saturday morning and then not eat again until Sunday morning. And again, I'm usually not training or doing much around that. If I do train, I try to focus only on a long endurance, usually like a zone two type of exercise because I'm getting into that ketosis and I'm trying to stimulate fatty acid oxidation. And so I pair those up to try to enhance my ability to mobilize fatty acids and to utilize the fatty acid oxidation aspect. So I don't do a whole lot of high intensity strength training or power training in those realms when I'm doing my fast.

Melanie Avalon
Okay and then major question for you because we get this all the time. So when you are doing the type of training to build muscle, how soon do you need to eat protein after working out?

Dr. Christopher Meadows
Yeah, so that depends on how long you've been working out and how long you've been taken in your high protein meals because your body can adapt. When you're newly into exercise regimens and newly into paying attention to your nutritional side of that, the impact is greater by consuming your protein closer to the workout.

But your ability to consume and absorb and utilize the amino acids that you consume in your diet are improved with a more regular exercise regimen. So the more you work out, the more consistent you are in your exercise regimen, your ability to utilize and absorb protein is improved for longer periods of time. So it's not as important to take in within the first hour or first two hours. I still try to do that because I work out in the morning and then I'm going to get a big breakfast before I head out to work. So that's my rhythm and how I do it. But it's not as important, the more trained you are, but if you're early on to the exercise world and you're starting a new exercise regimen, then taking in a good slug of protein shortly after within that first hour is going to be ideal.

Melanie Avalon
Awesome, yes, we get that question all the time. Awesome, well, is there anything else?

And for listeners, this is so exciting. You can actually get 50% off a consult with Dr. Meadows at his practice. If you go to ifpodcast.com slash clinic5c, so that's ifpodcast.com slash clinic, the number five, the letter C. So thank you so much. What is the purpose of these consults? So is this for what type of people should come to you for this? Like what type of issues?

Dr. Christopher Meadows
Yes, great. Thank you for that.

A consult with me in the regenerative medicine space can be anything from an orthopedic-related condition, it could be autoimmune conditions, it could be any questions you might have surrounding the potential utilization of regenerative technology, stem cells, PRP, et cetera, to support the healing process of whatever you may be dealing with. And so a predominant, a good portion of my practice is in the orthopedic space, but we're recognizing how impactful these tools are being across the board of different diagnoses, neuronal health, cognitive impairment, that's what we started off with. Again, autoimmune processes, which I think is going to be the next big area in which stem cells are going to be beneficial for because of their immune modulating capacity.

So it could be across any of those. And again, I can kind of help patients guide them in the direction of what potential therapies there are out there. And again, we talked about some of the protocols, both pre and post-operative. So anything amongst those different avenues, I'm certainly here to available help.

Melanie Avalon
Amazing. And are those consults done virtually? Can they be done virtually?

Dr. Christopher Meadows
They can be virtually or if you're in the area in person, we offer both.

Melanie Avalon
And if people want to work with you, is any of that virtual or are they going to need to come in person?

Dr. Christopher Meadows
If there's any treatment that's recommended that we offer, of course, that's going to be in person, I certainly can offer the insight that I have into lifestyle management or adjustment treatment ideas that I would have. But if there's any sort of, of course, we talked about diagnostic ultrasound and ultrasound guided procedures, if any of that is recommended, I can certainly point you in the right direction if you're not able to travel up here.

But otherwise, if you're interested in me personally doing any of that, then of course, we'd have to do a little bit of traveling, but hopefully not too bad.

Melanie Avalon
And anything else? Thank you so much, Dr. Meadows. This has been so amazing, just so enlightening.

Is there anything else you wanted to touch on from your practice or especially, you know, with you what you were saying earlier in the show about how important education is to you? Just anything that you would like to educate our audience on?

Dr. Christopher Meadows
Well, I'm just excited to be here. I am thankful that I have the platform to continue to talk about stem cell therapies and regenerative medicine. I think it's a growing area of interest and a growing area of science, and I'm excited that I have the opportunity to share that with your audience here, and I'm grateful to have the opportunity to chat with you.

We've covered a lot of ground. There's still so much that we can chat about, but I think we talked about a lot of stuff here, and I'm grateful to have had the opportunity.

Melanie Avalon
Yeah, no, this was so, so wonderful. I'm just so, so grateful for everything that you're doing because like I was saying throughout the show, it's, it's really hard to, it can be hard for people to find, you know, sources where they can actually, you know, make change and what they're experiencing, especially when it comes to pain in their body and your approach is just incredible. It's fantastic. Thank you for everything that you're doing.

And yes, so again, so listeners, these show notes for today's show will be at ifpodcast.com slash episode 438. And those show notes will have a transcript. They'll have links to everything that we talked about. And again, you can get 50% off a consultation with Dr. Meadows and check out his clinic's website when you go to ifpodcast.com slash clinic5c. All right. Well, thank you, Dr. Meadows. Are there any other links you want to put out there?

Dr. Christopher Meadows
Yeah, so you can go to our website clinic5c.com. I am also on Instagram, meadows.md, so you can follow me there as well.

And so you can also connect with me. I'm on there pretty regularly. I chat with patients and answer questions there as well. So there's a couple areas that you can get some more information.

Melanie Avalon
Awesome, awesome. Well, we will put that on the show notes. Thank you so much for your time and we will talk again in the future.

Dr. Christopher Meadows
Look forward to it. Thank you.

Melanie Avalon
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed.

If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by podcast doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week! 


 

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