Episode 315: The Oldest Cure In The World, The Fascinating Fasting History, The Subjugation Of Women, Religious Fasting, Bernarr Macfadden & The Body Beautiful, Starving Cancer Cells, Fasting Clinics, And More!

Intermittent Fasting


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Apr 30

Welcome to Episode 315 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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1:10 - NUTRISENSE: Get $30 Off A CGM Program And 1 Month Of
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3:50 - BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
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The Oldest Cure in the World: Adventures in the Art and Science of Fasting

10:05 - The Research That Went Into The Book

13:00 - Steve's Personal Story

The Melanie Avalon Biohacking Podcast Episode #87 - Dr. Alan Goldhamer

18:00 - Dr. Henry Tanner, The Father Of Fasting

25:55 - Why Don't Doctors Believe In The Power Of Fasting?

31:20 - Heroic Medicine

35:15 - Historical Theories About Endogenous Energy Sources During Fasting

37:30 - Why Didn't People Notice It Was Fat That Was Being Burnt For Energy?

39:30 - Fasting In Greek History

45:45 - Fasting In Religion

49:10 - Women Taking On The Role Of Fasting 

55:10 - catherine of siena

54:00 - ATHLETIC GREENS: Get A FREE 1 Year Supply Of Immune-Supporting Vitamin D AND 5 FREE Travel Packs With Your First Purchase At athleticgreens.com/ifpodcast

55:00 - The Oppression Of Women Through Diet Control

1:00:45 - Jainism

1:04:50 - The Loss Of Fasting In Christianity And The Creation Of Lent

1:12:15 - Bernarr Macfadden

1:19:00 - Upton Sinclair

1:26:10 - The Dismissal Of Fasting In  Fasting In Modern Medicine

1:28:20 - "Tricking" People Into Fasting

1:30:05 - Valter Longo And Fasting Mimicking Diet

The Melanie Avalon Biohacking Podcast Episode #115 - Valter Longo, Ph.D.

1:35:35 - AVALONX MAGNESIUM 8 - Get On The Email List To Stay Up To Date With All The Special Offers And News About Melanie's New Supplements At avalonx.us/emaillist, And Use The Code Melanieavalon For 10% On Any Order At Avalonx.Us And MDlogichealth.Com!

1:39:20 - Fasting Clinics

1:42:05 - Alan Goldhamer's Data On Blood Pressure 

1:46:30 - Steve's Experience At The Clinic

1:49:40 - The Future Of Fasting

1:53:15 - Steve's Fasting Practices

Early Vs Late-Night Eating: Contradictions, Confusions, And Clarity


Melanie Avalon: Welcome to Episode 315 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat not what you eat, with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of What When Wine and creator of the supplement line AvalonX. I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of Keto Essentials and creator of the TONE breath ketone analyzer and Tone LUX red light therapy panels. For more on us, check out ifpodcast.com, melanievalon.com and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. Pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time and get ready for The Intermittent Fasting Podcast. 

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One more thing before we jump in, are you fasting clean inside and out. So, when it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you what is possibly one of the most influential factors in weight gain. It’s not your food and it’s not fasting. It’s actually our skincare and makeup. So, as it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disruptors, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we’re using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream.

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Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That’s why it’s up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies and so much more.

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Hi, friends. Welcome back to the show. We have a super special episode today. This is going to be a little bit different from our normal show. I interviewed Steve Hendricks on my other show, the Melanie Avalon Biohacking Podcast. He is the author of an incredible book called The Oldest Cure in the World: Adventures in the Art and Science of Fasting. Friends, that book blew my mind when I was reading it. I was just like, anybody who's even remotely interested in fasting or even if you're not, needs to read this book because it is that fascinating. So, when I aired it on that other show, I immediately knew I needed to air it on this show as well. 

We talk about so many things, like the role of fasting in historical cultures. Did the Greeks actually fast? We talk about fraud in fasting. Yes, that is a real thing. We talk about how fasting might have actually been used to control women historically in the Christian church. That's interesting. We talk about Valter Longo and the fasting mimicking diet, Dr. Alan Goldhamer and TrueNorth Health Center. We talk about some pretty crazy, more modern people in fasting. Really just be prepared to have your mind blown when it comes to all things fasting. So, I really hope you guys enjoy this episode. 

This is also serving as a transition episode between co-hosts. So, Cynthia Thurlow has been the co-host of this show for about the past year and we talked about this in episodes leading up to this, but she is actually leaving the show. And so, next week we have our new co-host, Vanessa Spina, also known as Ketogenic Girl and host of the Optimal Protein Podcast. Friends, you are going to love her. I am so excited about this. So, get excited for that. Take this moment as a sort of intermission and definitely let me know what you guys think.

By the way, if you enjoy this show, you'll probably really like my other show, the Melanie Avalon Biohacking Podcast, because it's basically like this show. I interview so many people, the world's top doctors, authors, and researchers on all things health and wellness. We're talking physical health and diet and exercise and mental health and wellness. I bring on people from all different perspectives. So, the best of the best in the keto and carnivore sphere, the best of the best in the vegan world. I've interviews with companies for products that you guys love. So, Joovv, red light therapy, Dry Farm Wines, NutriSense CGM, Tim Spector with the ZOE program. Of course, I've also interviewed figures that you guys hear a lot about, like Valter Longo, Jason Fung, Megan Ramos, so many things. So, definitely check out that show. In the meantime, enjoy this fabulous conversation with Steve Hendricks. 

Steve, thank you so much for your time and thank you for being here. 

Steve Hendricks: Oh, it's great to be with you, Melanie. I hope I can live up to that fantastic and very kind introduction. Thanks a million.

Melanie Avalon: I have so many questions for you. I want to hear your personal story, but just a question to start off because I'm so curious. I mean, this book is like a textbook and it's like all of this history. How do you find all of this information? Do you look at Wikipedia? Where does one go to collect all of this information? 

Steve Hendricks: Yeah, I mean, the difficulty is that it's not in any one place, but that's of course, what makes I think the book very valuable. What I wanted it to be was to be both super comprehensive and it sounds like I checked that box for you, which is great. But I also wanted it to be lively. I wanted it to be a more vivid with characters and stories, a very relatable chronicle that people could-- you wouldn't think of a fasting book as a page turner, but that was my aim. My aim was to have the pages just fly by even though there was a lot of information. Now where do you go to find it? The book is sort of divided into three sections that are all sort of intertwined and overlapping. But as you said, it's the history of fasting and the science of fasting and my own experiences with fasting.

So, for the science of fasting, I go exactly where you go, which is reading those scientific studies and interviewing the most prominent researchers who have something interesting to say. The history was the trickier thing because there's so much written about the history of fasting, and unfortunately, a ton of it is wrong. So, you really have to dig pretty deep. And quite often there was an academic at some point will have written a book about fasting for a certain 500-year period in the Middle Ages, okay, awesome, great. So, I've got that period covered. Now what do I do about the other, like 2000 years of history before that and it's a real mix. 

Sometimes I'm reading academics books, sometimes I'm reading their studies. In a few cases, I'm going to the actual Greek or Latin or whatever sources, and I'm trying to find someone on social media who will be kind enough to translate sentences that I'm having trouble figuring out. But most of the time I'm relying on-- I'm a reporter, so I'm reporting on the work of academics. Unfortunately, while there's not as much out there about fasting as we'd like, there is a ton out there if you just uncover all the stones. That's what added up to the book. 

Melanie Avalon: I'm just blown away. I can't even imagine how much you had to read to get to it. I will say so you check the box about the comprehensive history. You definitely check the box, the second one about being lively and creating characters and page turner. There were literally times my mouth dropped open when I read parts about some of these things happening, which we can get into in this show. 

Steve Hendricks: If you could see me blushing now, don't stop, don't stop. 

Melanie Avalon: No, some of the stuff about the females fasting and the religious aspect of all of that. There're so many things. We can circle back to all that. Before that, your personal story, obviously, this is in the book. I'll just say, friends, listeners, we're not even going to remotely touch on everything in this book, so just get it now and you can hear everything. But you do share a lot about your personal fasting experience. So, could you tell listeners a little bit about that? You're a reporter, why did you become interested in fasting? Why are you writing about it now? I know you tried to write about it earlier and things happened with that, so why are you where you are today? 

Steve Hendricks: Yeah, so I first started writing about fasting in an article that I published for Harper's Magazine about 10 years ago. That was back in a time where there weren't a lot of people fasting as there are today. And so, it was viewed with a lot of skepticism. I wrote that article because I had come to become fascinated with fasting myself and I had practiced it myself. The center piece of the article was this 20-day fast that I had done. At that time, I was about 40 years old, maybe in my late 30s when I did this. 

I fasted for two reasons, one of which was the one that so many people come to fasting for. I just wanted to lose weight like a lot of people. I had put on a pound or two every year in my 20s and 30s and I'm 5'9" on a good day and I was weighing close to 170 pounds, whereas when I was at my lean in college I'd weigh 140. Partly I just wanted to lose weight. But I'd gotten interested in fasting and learned about fasting in the first place because I also was very interested in fasting for longevity.

I had originally started with caloric restriction, which as most of your listeners probably know, just means sharply limiting how many calories you're getting every day while still getting all your necessary nutrients. The problem with CR - caloric restriction is it is just fiendishly hard to do. It is just impossible. You're walking around hungry all the time and if you're a mere mortal like me, you're not some superhuman person. You just can't stick with caloric restriction. But the irony, well, of course, is that you can get many of the exact same benefits from a prolonged fast as you do in caloric restriction, yet you don't feel hunger. The irony is by doing the most calorically restricting thing of all just simply not eating, your hunger actually gets suppressed and so it becomes a much more doable thing. 

So, this was very appealing to me. So, someone who weighed too much and wanted to weigh less and was curious because I'd read these historic accounts of people who'd done long fasts. I wanted to see what it was like. Now I'll caution and say, knowing what I know now, I would not undertake a 20-day fast on my own without some kind of medical supervision because there are too many things that can go wrong. I'm not telling the audience what to do or what not to do, but I want to caution that fasting doctors have very good reason for saying you don't really want to be doing really long fasts on your own because some things could go wrong. But with that caveat, I did that 20-day fast. It went fantastic. I had a lot of ups and downs that a lot of other people have described when fasting, but ultimately found it to be a very satisfying experience and I lost all the weight that I wanted to lose. 

So, it was fantastic and I wrote this article and I'd like to tell you that in the 10 years since I wrote that article, it's all been a carpet of rose petals in my path, but that has not been the case. We can talk about that, but my health actually deteriorated over the years throughout my 40s, I'm 52 now, and it was eventually fasting and I believe dietary change that have rescued me. 

Melanie Avalon: That was something that I loved was that you've had so many experiences with fasting. Like, for me, I started doing intermittent fasting in college and I did the type I'm still doing today, which is one meal a day, eating at night. I haven't done a long, extended fast like you. I haven't done-- you've tried ADF, you've gone to fasting clinics. I was really thrilled because in the opening of the book, you talk about and throughout the book, Alan Goldhamer, who I've had on the show at TrueNorth and I was super excited to hear your experience there.

So, it's super valuable, I think that you have had experience with all of these different fasts. There's something I wanted to comment on really quickly. I love the distinction that you have between fasting and calorie restriction. For example, you talk in the book about people looking at World War II and starvation and saying, “Well, if fasting has all these health benefits, why did people not get really healthy from starvation in World War II.” And it's the subtle nuance of having just enough calories to not let you actually be fasting. And then they're also malnourished not having enough food so, there's so much complexity, and I'm so happy that you tackle all of it. There're so many directions I want to go with this. You talked about the colorful characters in the history of fasting. I imagine because there were so many different people, why did you settle on Dr. Henry Tanner as the father of modern fasting and why did you choose to open the book with his story and everything that he did? 

Steve Hendricks: Yeah, great question. So, Henry Tanner was this doctor who was born in the 1830s, say he was a doctor. He was indeed a doctor, but not a medical doctor. He was what was then called an eclectic doctor, which is something like a naturopath today. So, he was an alternative medicine practitioner and somewhere along the way he had picked up fasting, short fasts, a couple of days here, three days there as a useful tool. Well, it turned out in 1877, he had fallen on hard times. He had just lost his wife. He was living in Twin Cities of Minnesota then and he had all kinds of ailments. He had a stomach condition that may have been a stomach flu. He had basically something that sounded like a nervous breakdown. He had heart problems and so on. He decides then that he's going to fast long enough to either cure himself or by one account kill himself and he didn't care what the difference was. 

So, I started with him in part because he's such a quirky character. I'm not very good at remembering my own quotations and so on, but some of the things that he said were just out of left field, but also because he was the first person who in a scientific kind of way-- in a case study, scientific kind of way, sat down and said, “Well, I'm going to fast, and I'm going to see if fasting cures me and see what happens.” And he did it, there had been previous doctors along the way who had been noticing these cures and trying to write about it, but he did it in a way that got the message out to the entire world. What happens is he does this fast. At this time, it was expected-- people thought at this time you could not go longer than 8 to 10 days without food or you would die. 

What Tanner found is when he reached 8 to 10 days, not only had all of his problems started falling away and all of them eventually got cured in the accounts that we have of this fast, but he felt even better, he felt even stronger than he ever had before. And so, he ended up finding out on day 20 something or whatever of his fast, because he just kept going and going because he was curious to see how long this fast could go without his suffering. He would find himself walking 10, 15, 20 miles a day, which is vigorous exercise for 1877. That could be a lot of exercise today. So, he does this fast, he cures himself, he breaks his fast after 41 days, and he had no intention of advertising it, but a friend of his, another doctor who had helped sort of supervise him during his fast, reported it in a medical journal in Chicago. 

It got out to the world and everyone just completely ridiculed him, said, "He must be lying. There's no way that you could fast this long." Through series of other events, he's wanting to prove himself to redeem his name and an opportunity arises for him to go to New York City three years later in 1880, and there to repeat his fast of 40 days on a stage in front of people in New York. He was completely ridiculed at first, but there was this prurient interest in his fast because, oh, my gosh, he's going to fast beyond perhaps 8 to 10 days. What's going to happen? Is he going to die on stage? Interest grew and grew. This was a presidential election year. He was getting more coverage than the presidential contenders. His feat was being recorded all over the world. He went through the 8 to 10 days with no problem and kept fasting for 20 days and then 30, and eventually broke his fast at 40 days. 

What happened with this, unfortunately, when he was in New York, he didn't have anything wrong with him. He wanted to prove that fasting could cure, he didn't have anything to be cured, so it didn't make the splash that he wanted it to make. But because it was reported in every newspaper in the United States and most of the newspapers in Europe and even some in Africa and Asia, he got the message out, the idea out that fasting might just be curative. And from that point on, that's really where we see this more scientific interest in fasting for health taking off in a way that it never had before, because it's fasting and it's counterintuitive and people don't want to do it. It was a very, very slow growth to get from there to where we are today. But without Henry Tanner, we wouldn't be where we are today. 

Melanie Avalon: It sounds like social media, like the first-time fasting was in the eye of the public, and everybody was paying attention. So, on this stage, he literally just sat on the stage? 

Steve Hendricks: It was a very barren stage because they wanted to make sure that there wasn't any hidden food and that no one would sneak food into him. He had a cot and he had a chair, and people could bring him reading material if it had been searched before. It got to the extent that if people were sort of reaching up and shaking a hand with him, they would inspect his hands to make sure that there wasn't food being passed to him, being palmed off to him or something. So, yeah, it was just sitting there and talking with people for 40 days. Newspaper editors sent over teams of reporters to watch him for 24 hours a day. He also had his own sort of core of watchers drawn from medical students and other doctors and so on. But, yeah, it was just sitting there doing nothing but not eating. 

Melanie Avalon: What was the significance of his show off with Dr. Hammond?

Steve Hendricks: Yeah, so, Dr. Hammond, who was a former surgeon general of the United States, he was part of the occasion that gave Tanner the reason to go to New York to fast, and that's that Dr. Hammond was extremely skeptical of a group of women who were called the fasting maids. These were women who usually actually girls more than women, but young women and girls who had claimed a fasting power. They would claim that they could go months or in some cases even years without eating or with barely eating. And it was completely fraudulent. Not a bit of it was true. He had made it his mission to unmask these fasting maids. He'd even written a book doing his best to unmask them. It happened that there was one in Brooklyn in 1879, 1880, who had claimed to go, “I forget forever, basically, with hardly eating anything.” 

He had challenged her. Her name was Mollie Fancher to fast in public under the watchful eye of doctors round the clock. She said no, she could not be examined by male doctors. Her feminine honor would have been impugned and so on. That was the point at which Henry Tanner in Minneapolis, because all this was being reported in the newspapers around the country, Henry Tanner said, “Well, I'll come to New York and I will fast in her place.” 

Melanie Avalon: Hmm, got you. 

Steve Hendricks: I'm sorry you asked, so, what became of the standoff? Well, eventually, Hammond had to admit that people could, in fact, go longer than he had ever expected without food. He still, of course, rightly, thought that the fasting maids were a croc, but he had to revamp and revisit his ideas about just how people could survive in the absence of calories. 

Melanie Avalon: Yeah. Something I liked about that, like I called it a show off was. It felt like an analogy for a theme throughout the history of fasting with conventional medicine. People positing this other idea of fasting because it seemed like you're talking about how Hammond was a very respected conventional doctor and Tanner was of a different, I don't know what the word would be like woo-woo or alternative. So, it seems like that was a theme throughout, especially later in the fasting history, I think, there were so many forces against fasting. 

Steve Hendricks: Yeah, emphatically so, conventional doctors have always had a hard time accepting fasting and even today, it's the rare conventional doctor who will look at the science. 

Melanie Avalon: Yeah, yeah. Why do you think if you had to pick one, well, you don't have to pick one, but if you had to why do you think that is? 

Steve Hendricks: Sure. No, that's a great question. That's one I've been wrestling with for about 15 years. I think the biggest reason is simply this. Fasting is premised on the idea that the body can heal itself. If we get out of its way, it knows what to do. Now, it's not a cure all. I'm not saying it's going to fix every single disease, but my goodness, it can reverse cardiovascular disease and arthritis and diabetes and even one form of cancer, at least. I could go down a list of 50 diseases that we have good evidence that fasting, prolonged fasting in particular, can reverse. That is not something that doctors have been very good at hearing. 

Certainly, and I make this case throughout history, there was a period, even in the early 19th century, where the form of medicine that was most widely practiced by conventional doctors was called heroic medicine and it was horrible. The whole premise of it was, the doctor is going to be the hero. He's going to come in and save the day, and he's going to do this by bleeding the patient of-- leaders of his blood, of making him vomit, of making her have diarrhea with a purgative, of blistering the skin and all this that we're going to just whip the disease out of people, and it undoubtedly killed more people than it helped. 

But that mentality, of course, doctors aren't doing that badly today, but they still have this mentality that disease is something that we have to conquer with technology, with our know how, with our fancy medical degrees and all the stuff that we've learned in medical school and our residencies and so on, and letting that go and saying, “You know what?” If you just back off and monitor these people, make sure they stay healthy while they do their fasting, their bodies can actually do the healing without you. It's that without you part that's very threatening to conventional doctors. I'll just close this little sermon by saying, “Look, I've gotten a lot of benefit out of Western medicine. I think conventional medicine has a lot of amazing points to it.” So, I'm not trying to condemn all of conventional medicine. It has saved me more than once. However, this is an enormous oversight and I think that's where doctors fall down. 

Melanie Avalon: I'm so glad you brought up the heroic medicine. I was saying in the beginning how I'd have moments where my jaw dropped open hearing the things that people would go through with that. I just kept asking myself, “Why did people let these doctors do this to them?” To that question, was it a cultural zeitgeist of just believing the system that these things were helping? Was it ironically enough, the fact that because the body can heal itself that if people survived the heroic medicine and then the body healed themselves, then they would just credit the heroic medicine? How did this go on for so long? And relatively recently, if you think about it wasn't that long ago that this was happening relative to humanity. 

Steve Hendricks: True. Some iterations of this were continuing into the 20th century, for sure. It's some of all of what you say. So, yes, every time you tortured someone [laughs] who was sick and that person didn't die, well, gosh, if you were the doctor, you could claim that your heroic medicine saved them. And so, in the absence of the scientific method existed, but it was really rudimentary back then, and in the absence of any real science, it was just impossible for people to prove. You could discount it. You could say, oh, I doubt that, or something, but you couldn't prove that the heroic medicine had been more harmful than helpful. But I think the other piece of it that you hit on as well is it is an extremely counterintuitive thing for all people, not just doctors, to accept that if we leave our body alone, it wants to heal itself. 

So, you find these accounts when you go back and look through the history of medicine, of doesn't matter where it is. It could be the US, it could be Germany, France, Russia, you find these accounts from 100, 200, 500 years ago where a doctor writes something along the lines of, “It seems that if I leave my patients alone, some of them actually do better than when I give them the medicines.” That was emphatically true back then, the medicines of the day were almost all quackery, unless, by luck, they happened onto some herbal remedy of some kind. They seem to get better. But here's the problem. When a patient is sick, they call me to their bedside and what they want is a cure. They want a pill. They want a potion. It's very much like today. They don't want to hear, “Go home and don't eat for three days and see if that makes your fever better.” 

It's an extremely hard thing for people to hear and you can understand why. I mean, when you have all the science, it just seems ridiculous, like you want to just shake these people. But in the absence of the science, what people are left with are their own impressions. Well, what do we feel like when we don't eat well? We feel weak. Our minds quite often slow down. We're not able quite often to do the same amount of work as we did before. Everything in our own experience tells us that not eating does not make us feel better. I think when a doctor comes along and says try this, it's an extremely hard thing to accept on both sides of that picture, both for the skeptical doctors who doubt this remedy and for patients who are equally skeptical throughout history. 

Melanie Avalon: Chronologically, it's hard prescribing fasting for all the reasons that you just mentioned, and then retroactively, if the person does heal, there are so many examples in the book where fasting won't even be credited. You talk about the woman at TrueNorth Health Clinic and her spontaneous remission. They wouldn't say it was the fasting that did it, it was just spontaneous remission. Or you talked about, I think, a study looking at or I don't know if it was a study, but it was something looking at keto versus fasting-mimicking diet and fasting for epilepsy. And they didn't credit the fasting. They credit the diet aspects. So, even when fasting does work, it's like we can't give it the credit for what it did. 

But another thought that this made me think of was there were so many moments in the book where it was things I just took for granted that it had never occurred to me that people historically were not aware or saw things completely differently. So, for example, the idea that what we burn when we're fasting, could you talk a little bit about theories that people had about what we were running off of energy wise? 

Steve Hendricks: Isn't that incredible? We all know that we run on our fat, at least for most of the time. Yeah, we burn a little bit of protein and so on, but it's basically our fat. But no, people didn't know that, even as late as Henry Tanner's day. So, again, we're talking 1880. There were scientific journals about, there were scientific studies of nutrition and body composition and things like this. People debated endlessly what he was surviving on. Some of the theories were that the water that he was drinking had what were called animalcule, which was just these fancy word for just tiny, tiny organisms in his water, and that his body was surviving off of digesting those organisms. Other people believed that the air contained nutrients and the more people who were around then the more nutrients were being-- In theory, the nutrients were expelled by people who were breathing them out of their bodies, and then other people could breathe them in.

If you weren't eating, you could be nourished by breathing in these nutrients. There was one person who accused Henry Tanner of doing this fast in New York, because there were millions of people there. So, far more people breathing into the air. Other people would claim, of course, fasting has mostly throughout history been used for religious purposes, so people would claim divine assistance of some kind. That was, of course, the mechanism was never stated, but basically you didn't need to eat because your stomach was filled by the Holy Ghost or Jesus or whoever it was you were crediting that to. So, yeah, it was a quite a while, really, until the 20th century before people were-- science had settled the question of what do you burn when you're not eating, you burn your fat.

Melanie Avalon: I think one of the other ones was like, women burning their menstrual cycle or living off of that. 

Steve Hendricks: Oh, right. [laughs] 

Melanie Avalon: Crazy. Do you think if we had had the obesity epidemic earlier so if people were overweight-- When people lose weight from fasting or calorie restriction today, people can lose a lot of weight, and you can clearly tell something left their body, so it seems more obvious that you burned something away. But do you think because people weren't-- we didn't have obesity to the extent that we did today, it wasn't as noticeable that people were losing fat? 

Steve Hendricks: Yeah, that's quite probable. Another piece of it is, in order to lose a whole bunch of fat, you have to fast for a very long time. Although fasting has been around for a very long time throughout most of history, most people when they fasted were fasting for only a few days. There were a few people who fasted weeks or months, but they were very, very rare. So, even if you were obese, let's say you're my height, 5'9", you weighed 300 pounds, you fast for three days, you're not going to notice any fat loss. It's going to be very, very subtle. So, I think that was a piece of and that also changed after Tanner's fast. Once people realized in the late 19th century. "Oh, my gosh, you can fast 40 days and survive." Then you got people who were doctors, who were occasionally fasting patients as long as 50, 60, 75 days. And then, of course, it would have been extremely noticeable at that point whether the person was overweight or not, that they were losing their fat. But that didn't happen throughout most of history. So, that's probably a piece of it. 

Melanie Avalon: And so, you touched on this little bit just now with the types of fast that people were doing. You touched on it in the beginning about what was or was not true. So, something that really blew me away was, I think, for most people, if they think about the history of fasting and what they think they know about it, there's just this idea, like with the Greeks, for example, we think Hippocrates was all about "Let food be thy medicine." I guess we can question if he even said that. But there is this idea that, “Oh, the old ancient people knew what they were doing, and the Greeks were fasting.” And were the Greeks really fasting? What was happening there? What was the role of fraud in the history of fasting? 

Steve Hendricks: Yeah. So, I first started fasting, I was greatly relieved to hear that fasting was this ancient practice. If you're into fasting, you've all seen these quotes. Supposedly Plato had written, “I fast for greater physical and mental efficiency.” Plutarch said, “Instead of medicine, fast a day.” Hippocrates said, “To eat when you are sick is to feed your sickness.” There are all these quotations and stories out there and it turned out on examining them, one or two of which I had even related myself from what seemed like reliable sources when I first wrote about fasting a decade ago. When I dug deeper and really looked at the sources, it turns out, no. Almost none of that. All those quotations I just said, all bogus, every one of them. 

Melanie Avalon: It's crazy. 

Steve Hendricks: Yeah. And they're repeated, I mean, some of them were created pretty recently, within the last few decades. Some of them, there's a story about Pythagoras who was said to have fasted, was made to fast, before he became a student in Egypt for 40 days. Didn't like it, but he did it, fell in love with it, and made all of his students fast for 40 days as well, before they started studying with him. Well, it turns out that's not true. It wasn't something that was developed yesterday. That was developed by people who were trying to glorify Pythagoras and associate him through the 40-day fast with the 40-day fasting of Elijah and Moses and whoever else. So, anyway, these stories are told for various reasons, but the reason they persist today is because they are extremely comforting to people who are doing this weird thing that, until very recently, no one else was doing. They provide this kind of sense of, “Oh, you are part of this long worthy tradition with these noble people who came up with mathematical theorems and so on. So, it must be a good thing.” 

In fact, the truth is, while it's true that we owe probably the first really deep signs anyway of therapeutic fasting to the ancient Greeks and to people around the time of Hippocrates, they had no idea what to do with it. The reason they had and they had no idea what to do with just about anything to do with medicine. The reason is because there was a taboo on dissecting bodies. You couldn't look inside the body, you couldn't see what was going on, so, they made up these cockamamie theories. The one that eventually won out was called humoralism. It held that if you keep your body's four humors in balance, those were black bile, yellow bile, phlegm, and blood. So, they believed if you kept them in balance, then you would be healthy. When they got out of balance, then you would be unhealthy. That's why you get to such things as bleeding people, is that's to try to get their blood amount back in balance. Well, it was all completely nonsense, but all of medicine was based on that. 

The few things that have come out about fasting from this time are just useless, almost all of them. So, for instance, a writer in the Hip-- I should say, we don't know if Hippocrates wrote any of the works that are ascribed to him. There are about 60 works in the Hippocratic corpus. They were probably mostly written by family disciples, whatever, some by impostors. But anyway, within the Hippocratic corpus, one of these Hippocratic writers will say something like, “When you have hiccups or you have muscle spasms, you should either fast or overeat.” And it's like, “Well, which one?” Those are opposites. It was full of this kind of nonsensical stuff. 

Now, all that being said, the Greeks did because they were open to fasting and because their big contribution, big contribution that Hippocrates and his colleagues made was that previously medicine was just seen as something that happened by divine fate or something. They said, “No, there are actual causes to diseases. We can learn to understand what those are, and sometimes we may be able to treat them.” Now, the fact that their treatments ended up being wacky doesn't discredit this enormous advance they gave us. And because of that advance, people over the centuries started experimenting with fasting. Eventually they got around to just through random chance practically stumbling on some things that did seem to work here and there. They weren't very prominent, they didn't last super long, but you could see these kinds of bubbling up of fasting intelligence over the years. 

One of the reasons I went into kind of what you're calling them fasting fraud of these ancient quotations and stories and so on is because I just don't think that they're so widespread, they're everywhere, they're unfortunately, every health website and anyone who talks about fasting usually resorts to one or two of them. What you find is I don't think that helps us. What helps us is not sort of covering ancient fasting in a glory that it doesn't deserve, but actually understanding where fasting came from, being humble about what things we did know and didn't know when as a species and therefore treating fasting with a lot more care, I hope. 

Melanie Avalon: I feel like now I need to go through all my blogs and my book and my podcast. I'm sure I've been sharing some of this misinformation. This is just a random tangent. The thing you were saying about how the cure for what was it for hiccups was either to fast or to overeat. I actually was reading a study about fasting the other day. I was researching fasting's effect on pain because of a listener question for The Intermittent Fasting Podcast, and I found a really interesting study, and it was all about how both fasting and eating can relieve pain. Super random tangent. [laughs] So, maybe there was something with the hiccups, I don't know. 

Steve Hendricks: Right. I mean, well, there could have been something there. Had there been a more scientific way of parsing through the various evidence, something might have grown out of that, but they just didn't have that at the time. 

Melanie Avalon: Yeah. You mentioned it in the book, but when we're looking at these quotes, how do we figure out that these sentences weren't uttered by these people? 

Steve Hendricks: Yeah, so the first clue is, if someone's not offering a citation, don't trust them. [laughs] They may well be right, of course, not everything has citations. But the simple thing to do is to go and look, to see who is making those quotations with citations and then just keep following them back like you'll find that I don't know that this quotation say, “Let food be thy medicine and medicine be thy food,” from Hippocrates, which you see everywhere and no Hippocratic writer ever wrote that. What happens is if you start chasing it back, one article will cite another article, which will cite another article, and often this is in the scholarly literature, but no one will be citing an ancient Greek source. Once you get back to the very earliest one of these, that's maybe in 1910 or maybe it's in 1842 or whatever, and you found that on Google Books or somewhere like that, if you go as far back as you can and there's nothing more beyond that, [laughs] then you have to conclude that it's probably made up. You can check some of these by, if you want, emailing your favorite, I don't know, Hippocrates scholar and saying this quotation seems to be completely bogus. Are you familiar with this in any of the Hippocratic writings, nope. They'll usually be able to help you out in such a straight.

Melanie Avalon: Yeah, it's so interesting. It speaks to a broader problem of that just happening in general, I imagine, in the scientific literature, because all it takes is some idea to slip into some journal somewhere, and then that's quoted, and then that’s quoted and then we're lost with it. I know that happened with, I think with the quote about how many top soils generations we have left. I know there was something about that. Like somebody said a quote about that at some conference without a citation, and then it made its way into some literature, and then it just kept getting quoted. But I imagine it happens with a lot of things. 

Steve Hendricks: Yeah. Once it makes it into an academic publication, whether it's a peer reviewed scientific journal or a book by an academic, forget it. Then everyone in the world will cite it, and it's just a lost cause. 

Melanie Avalon: Well, you mentioned 40 days a lot and I think probably a lot of people when they think of 40-day fast, they might think of Jesus' 40-day fasts. I was super fascinated by the history of fasting in different religions. Okay, so to start, here's a quote people will say all the time, they'll say that, “Fasting appears in every major religion.” Does it appear in every major religion? 

Steve Hendricks: It appears in almost every major religion. Now, you could split hairs over what's a major religion, but yes, in virtually every major religion. The one exception is Zoroastrianism, which is in Persia, modern day Iran, Zoroaster, the founder of Zoroastrianism. Almost all religions experimented, and some wildly adopted some form of asceticism just being really savage to your body. One form that was available to everyone was fasting. 

So, every religion, practically, certainly every major religion that has evolved has had to wrestle with what is the place for asceticism in our religion. Zoroaster, after experimenting with it, eventually decided that it was extremely harmful. He thought that fasting in particular would leave you too weak to farm, too weak to create productive and strong offspring. He chose a kind of more hedonistic almost view of the world and said, “No, we're not going to fast.” What's curious about this is that it's basically, as I say, a slightly hedonistic religion telling people that this is not a sin and that is not a sin, and you can do a bunch of things that these other religions won't. 

Well, today Zoroastrianism has 200,000 followers, and that's it in the entire world. Meanwhile, the religion, it mostly lost out to is Islam, which in some forms is very strict about what you can and can't do. And there are a billion Muslims. So, I don't know what the heck that says about human psychology, but that's a long way of saying that with the exception of Zoroastrianism, virtually all other religions, certainly the religions most of us have heard of had some place for fasting, but it varied enormously. Some places, some religions, it was a very small role. In other religions, it practically took over the whole religion. 

Melanie Avalon: In Hinduism, because I think that was one of the first religions you talked about that was primarily for enlightenment, was the purpose of fasting? 

Steve Hendricks: Yeah, I mean, the idea was that if you could eliminate desire, you could reach nirvana. So, they would do all kinds of ascetic practices. They would deny themselves sleep, shelter, clothing, family. This is the first time you really get into really ascetic monks who are doing an almost athletic like training for the soul. One of the ways was fasting, this idea that it was a way of renouncing desire, which Hinduism at that time certainly saw as a holy path. Early Hinduism is one place where fasting just grew and grew and grew. And you can see how it happens. If a little bit of fasting makes you holy, then a whole lot of fasting--

Melanie Avalon: Really holy.

Steve Hendricks: Exactly and that's exactly what happens. So, you eventually get to a point where there are Hindu calendars in ancient Hinduism that have 140 days of the year set aside for fasting. The sad part of it is, eventually the men who ran the religion decided that the people most in need of fasting were women. So, the fasting burden fell very heavily on women, very lightly on men. It took a reaction many years later to sort of tamp that down. But even today, if you speak to Hindu families and say, “Who in your family fasts?” You are much more likely to find women who fast than men do. And this is not an uncommon theme. This is exactly what happened in Christianity as well. 

Melanie Avalon: No. So, I think this was my favorite theme [chuckles] in the book. I was blown away by how often it occurred and what happened when it occurred. So, even with the Greeks, I think you said that when there was fasting, it was more with women, I don't know, that just never occurred to me. I don't remember which culture or time it was, but there was one example where women could fast because it was the one thing they could do. Like, men would go on vagabond things and they could do all this other stuff, but the only thing women could do was fast. 

Steve Hendricks: Yeah, during the Middle Ages, fasting really took hold in Christianity probably 100, 200 years or so after the death of Jesus, who didn't have much at all to say about fasting. Like most Jews who fasted him, he surely fasted, but he didn't have much to do with it. Early Christians didn't have much to do with it. But eventually Christians decided that the church fathers who ran Christianity at the time, that fasting could basically be used to subjugate women. The problem was that men were these very holy, devout creatures. But, yeah, they were little bit weak. They were tempted by this temptress woman who God had just put down here to torment male Christians was almost the view. And so, the idea was that you could neutralize female sexuality by getting women to fast. Sexuality was important, because by this time in Christianity, the sexual being had come to be seen as impure and tainting and so on. 

Fasting was supposed to dry up the moist humors. Remember the crazy humoralism we talked about earlier was predominating. Dry up the moist humors in women that were supposed to behind female lust. If you took fasting far enough, it could obliterate womanhood. It could pare the hips, get rid of breasts and buttocks, it could end menstruation. This wasn't supposed to be a punishment, so the church father said anyway, this was supposed to be something to aim for, to make yourself more holy, and your reward would be becoming a bride of Christ. This was quite literally meant some of the creepiest erotic writings of late antiquity.

Melanie Avalon: It's so creepy. 

Steve Hendricks: Isn't it? Are these scenes where Christ is uniting with his virgin brides in the heavenly bridal chamber or something? It's just obscene. It's not to say that every woman in Christianity fasted herself to this near starvation, but that was certainly the ideal that was held out. And so, you find by the time you get to the Middle Ages in the Renaissance, the vast majority of saints who are women in the Catholic hierarchy, who have been sainted, are these fasting saints. They have these very anorexic traits. Some of them literally starve themselves to death. Most of them just starve themselves into illness and probably an early death because of it, though, of course, we can't say for sure. That brings us to what you just referred to. 

Devout Christians were supposed to be practicing some form of asceticism. It didn't have to be as crazy as what the saints were doing and so on, but it needed to be something. Lots of forums were open to men, and one of the biggest ones of the day was called mendicancy, which is just going around homeless from town to town, begging, saying, “I'm a monk, I'm a brother of Christ, please give me food, or whatever." Your penance was to have or not penance, but your sort of duty was to have a life with few possessions and to live on the goodness of others. When women tried that, there were a few who did, the most famous is known as Clare of Assisi. When she tried it, she was told, “Well, this homeless vagabonding is not in keeping with pure womanhood, so get back into your abbey and forget this kind of thing.” And so, what was open to her was the power over her own body? 

So, on the one hand, while it was a very misogynistic, very horrible set of doctrine that were being handed to girls and women throughout Europe of this time. On the other hand, some of them did this kind of reclaiming thing. Well, okay, all you're going to give me is the power over my own body, I'm going to use it to starve my way to heaven, they would basically think. So, you have one theory anyways to how you got so many of these fasting saints. There was just nothing else or very little else left over that they could do that would achieve for them the equivalent amount of holiness as the men were achieving through their asceticism. 

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Melanie Avalon: Yeah. That was such a crazy ironic dichotomy that on the one hand fasting was used to really oppress these women and repress their sexuality and control them. And then on the other hand, it was like the one thing the women could do to assert themselves. [laughs] It's so ironic. My sister came over the other night and I was telling her about the book and about all of this and I was telling her about these saints who actually were probably anorexic and died from that, and then they were canonized as saints. I found the page in the book that you mentioned with those passages of the bride of Christ stuff, and I was like, “You have to read this.” It's just fascinating. You talk about Catherine of Siena, who is one of the probably anorexic saints that died. You can still see her body, like parts of her body at places. 

Steve Hendricks: Yeah. There's this creepy thing in Catholicism where they have, in churches and cathedrals, these reliquaries and the relics that are in the reliquaries are often the body parts of saints. So, when a saint would die, sometimes it's a whole body. But people everywhere wanted a little bit of something, so they might chop off a finger and send that to one town, chop off a foot and send that to another town. So, anyway, her body is scattered around Italy. Catherine of Siena was perhaps, no doubt about it, was the greatest, most powerful fasting saint. She had an influence over the popes of the time. She had an influence over various princes and so on and their political dealings. She helped propagate one of the crusades that was happening in her era. 

She died very early, almost certainly because she had weakened herself too much through too much fasting. So, she died in her early 30s. She died in Rome. She was from Siena and someone chopped off her head at some point and brought her head back to Siena. If you go into the Cathedral in Siena, you will see her head still there. You can google it. It's online. It's shocking how well preserved it is, given that we're talking about something kind of forget the dates, but six or seven centuries ago. But yes, it's this creepy thing that is done in a lot of Catholic churches to take these various body parts. 

Melanie Avalon: Because I think we like to think that we're beyond this, but do you think this theme has kind of continued with maybe not as much today with the health at every size movement, but, like, Parisian fashion and runway models. Is that a continuation of that theme? 

Steve Hendricks: Yeah, it's a very good question, Melanie. And I'm not sure. I went into such detail about how fasting has been used to oppress women, because food and how much you should and shouldn't eat is, of course, still being used to just ruin women's lives, even if it's in a much more secular way of, say, Paris Fashion Week than a dictum from the Roman Catholic Church. I don't know. I never found a scholarly article or report or something that drew a very clear line and said, this is why we're having trouble today. The parallels to what was going on in the past and what is going on today with women's bodies were strong enough that I just wanted to lay that out there. You're astute to notice that, to ask whether there's a connection. In the book, I don't say and that I don't say because I don't have answer. So, possibly yes, possibly no.

Regardless of whether there's a straight connection, I think we can learn from it. It's not a super sophisticated message here. It's just that women have been screwed over by usually men telling them what the hell to do with their bodies. And I especially wanted to be sensitive to that because I tell you, when I talk about-- I mean, I've been talking about fasting with people for 15 years hands down. The ones who resist it far more. The gender that resists it are women more than men. Well, it definitely has to do with some of these themes. Whether it's directly linked to what happened in history, who knows. I think we need to recognize that and understand it and be sympathetic to it. 

Melanie Avalon: It's such a complex and complicated topic, and you're talking about women being resistant to fasting. I definitely see it, just especially with The Intermittent Fasting Podcast and all the questions we get, because there are a lot of studies on the science of the health benefits of fasting, particularly in women and particularly for hormonal issues, PCOS, a lot of benefits that can be had. There's also a huge concern that women shouldn't be fasting. It's hard to piece out how much of that is from themes we all just talked about societal issues of women and eating or how much it's just that women might tend to over restrict and be too restrictive in diet and lifestyle and fasting. I don't know, it's just a very complex topic, and another reason I love your book so much. I hadn't considered the history of fasting in women at all as a piece in it. So, it's really interesting. 

Steve Hendricks: Yeah, I would love it if someone could come up with answer to that question. Hopefully some scholar will turn to that someday. 

Melanie Avalon: Another religion that was super interesting, Jainism. What happens with fasting there and there's suicide fasting?

Steve Hendricks: Yeah, it's really something. Jainism probably took fasting to an even greater extreme than Christianity did. So, Jainism, certainly at that time, the belief Jainism, Hinduism, and Buddhism all kind of grew out of the same, they're called Vedic religions in ancient India, and they've interpreted them different ways and often in reaction to each other. Partly because Hinduism, even as crazy as it was with fasting, and Buddhism, which was much more moderate with fasting, because they were both kind of on the slightly more moderate side than Jainism. Jainism reacted by taking fasting to quite an extreme and they took a lot of dogma to extreme. Their main view is that life is either suffering or it's causing suffering. Even grass is alive, so if you walk across the grass, you're causing suffering. The problem with that is that all organisms are composed of karma, which they've conceived of as these sort of literal bits, sort of like atoms. 

Your karma are mostly bad deeds and they keep the soul from soaring to heaven. They literally weigh your soul down so that it can't soar to heaven. Fasting, they decided, burned off bad karma. So, they would take fasting to some very extreme practices. One of them was this year long thing that they called Varsha Thapa which, if I remember it correctly, you eat nothing from sunrise until sunset 36 hours later. Then you eat after sunset. Once you've done that, you start all over again. At sunrise, fast another 36 hours till sunset. Eat a little more, do it again at sunrise. You do this for an entire year, which is just insane. So, they had all these practices, but the one that has gotten the most attention is this suicidal one you referred to. That was called Sallekhana and Sallekhana was simply starvation unto death. The original idea was that if you were as enlightened as you could possibly be, you had nothing more to achieve in this life. You had burned off as much karma as you could. Well, what was the point in continuing to live? If you continue to live, you might just rack up some more bad karma. You might inflict suffering. You could starve yourself to death.

Very, very devout Jains did this. We don't have an idea as to how many people did this over time. We're not talking millions here. We're talking probably well, today we think that there are probably a couple of hundred people a year who are doing this. Now, in modern times, it's been modified somewhat, so you don't have to be near enlightenment and so on. If you have a terminal illness, you've got a terminal diagnosis, there's no hope for you, you can starve yourself to death rather than suffering. 

There are cases in the west, of course, not just in Jainism, where people have done this, not a ton, but a few, who I speak of a writer, Sue Hubbell, who in 2018 got a dementia diagnosis and it was getting worse and worse and worse. And she essentially practiced Sallekhana. She starved herself to death for about 34 days. And so, people report that this is not a completely painless death, but it is much more painless than many other ways to go, and that the pain is very manageable and that all in all, it's kind of a peaceful death. So, who knows. I don't have much else to say in favor of Jainism, but it seems like an interesting thing to consider for those who are terminally ill. 

Melanie Avalon: Jainism, when I was reading about it, literally, it sounds like the definition of you just can't win. You just can't win. [chuckles] Everything you do is not good. How do you think that compares to somebody dying on their deathbed and then they stop eating and that's how they die? That seems to be very common or more common. 

Steve Hendricks: Yeah. There's quite often in the last stages of death, if you have a cancer or something, then it's just one of these lingering things where you've been dying of the cancer for six months. Quite often, in the last two days, three days, seven days, maybe you'll just lose your appetite and that's your body shutting down and basically preparing for death, as I have had it explained to me anyway. And I think that makes sense. This is a different category of thing, this is-- I have cancer, it's a terminal diagnosis, I could linger for six months and deal with the pain, the medication, the whatever else or I could starve myself to death and be dead in 30 days. In the Sue Hubbell's case, she had dementia. Heck, she was only, I think, in her 60s. She might have lived another 25 years. The difference is it's consciously seizing the opportunity to shorten that period of what for a lot of people would be hell. 

Melanie Avalon: Something I would love to know. I've never thought about this. I'd be super curious because we know of all of the processes that are activated by fasting and cellular renewal and all of the benefits. I wonder when a person is on their deathbed and then they do enter that state where their body is shutting down and they stop eating, I wonder if they still activate all those processes or if it's different. 

Steve Hendricks: Yeah, that would be really interesting to know because the reason that most of us, well, many of us fast is because it initiates all these repair mechanisms. If your body kind of has some inkling, I assume that it's going to die-

Melanie Avalon: Like nose.

Steve Hendricks: -right, [laughs] would it bother with the repairs? I have no idea. I don't think it's ever been studied anywhere. 

Melanie Avalon: It would be a sad and a morbid study. I would be very curious, though. Just before we leave the religious aspect because I think people, especially since Christian is such a large religion, they might have been surprised to hear that fasting wasn't as prominent or as big as a part as maybe we have thought it might have been, especially with Jesus and the 40-day fast and everything. You talk about how-- I think when Jesus talks about fasting, he talks more about doing it in private rather than public. So, like, Lent, what's going on there?

Steve Hendricks: Yeah, so that's a really good question. What happened was, after Jesus, we have what we think is a pretty good record of what he probably said. But He didn't lay out how to build an entire society and how to do everything. The church fathers had to come up with a lot of doctrine. Although the early church fathers sort of heeded Jesus-- Jesus had come and basically said all these silly dietary laws and everything else that the Jews are doing, you don't need to mess with that. Like, just, “Do unto others as you would have them do unto you.” If you obey that golden rule, then the rest will fall into place. Just don't get bogged down with 3000 laws. So, one of those things that people assumed that he was talking about was don't get bogged down with fasting. In the first century or so after his death, there was not much fasting in Christianity. I mean, some of them had just-- they had been many of them, most of them, probably Jews. Jews fasted, so they'd probably done some fasting and so on. 

But then, what happened was that the church fathers found that they could make fasting into something extremely useful to them. I've discussed the importance of subjugating women in order to keep them in their place and not tempt men. It wasn't all just that. I mean, that was a huge part of what was going on. But there was also, for instance, there came to be an idea that evolved a century or two after Jesus' death that was called the [unintelligible [01:07:58] angelicus, the life of the angels. The idea was that you should try to be on earth as much as you would be when you become angel or a deceased or whatever they thought they would be in Heaven. And angels were obviously incorporeal. They didn't have bodies, so they didn't eat. So, to the extent that you were able to model that here on earth, by not eating, by starving yourself, you could achieve this life of the angels here on earth or as close to it as you could possibly get. So, for reasons like this fasting took on a life of its own and it just grew.

Most people probably heard of the Desert Fathers and Desert Mothers, these monks in antiquity who would go out into the desert and do all these kinds of ascetic feats. One of their ascetic feats was to fast for days or weeks or months. And so, fasting kind of gained a momentum of its own. Remember how I said before that in Hinduism, there were eventually as many as 140 days or something like that of fasting on Hindu calendars. On Christian calendars, it expanded so much that by the Middle Ages and Renaissance, some places in Europe had 220 or 240 days of fasting throughout the year. I mean, it was just overwhelming how it grew to this proportion. So, Lent grew from that just same general expansion. It had eventually been Easter. Easter originally was the holiest day of the Christian calendar. It was also the saddest. It was occasioned for mourning because Christ had been killed, he'd come down to save us, and then there was the joyous resurrection. It ended kind of joyfully, but it was a very mournful period. 

The Church Fathers found that if you wanted to emphasize to people just how mournful they should be, how sober and how contemplative that they should be, you should make them fast. So, Easter got preceded by depending upon where this was enacted a day, maybe two days, eventually maybe three or four days or a week of fasting, which eventually, over time because again, same thing as what we were talking about with the Hindus and the Jains of a little fasting makes you holy, a lot of fasting makes you holier. It eventually grew to this 40-day famine before Easter and it was honored in different ways. 

Some people just sort of famously, as we know today, they just give up one thing. I should say more commonly among the more devout, it was a partial day of fasting each day. So, you might fast until 03:00 PM in the afternoon, have a light meal, maybe a dinner, and then you do it all over again the next day. It wasn't 40 days without food for most people. So that's how Lent grew. It was the way that fasting tended to grow throughout the more primitive parts of human history, which is just this simple idea of, well, gosh, maybe more fasting is even better for us. 

Melanie Avalon: Those fasting days, like you mentioned in Lent, were those the type of fasting days like in Hinduism, when they would have all those days on the calendar? Would they complete fasts or were they just eating lightly? 

Steve Hendricks: Yeah, so for most of those, when I say 220 or 240 days on some of these medieval European calendars, most people observe those by eating lightly. Some people would just observe them by giving up desserts or maybe they would give up meat. So, it was a partial fast for most people. For the most devout people who really honored it, they tended to give up all food until mid-afternoon and then they tended to eat lightly for the rest of the day. One would assume they gorged the next non-fasting day that they had in order to make up the calories, because otherwise they would have been in quite a caloric deficit. But that seems to be what happened. 

Melanie Avalon: Little ADF action going on. 

Steve Hendricks: Right, something like that. 

Melanie Avalon: So, I think when people think back through the history of Christianity, they think of the moment of challenging all of this dogma and doctrines would be with Martin Luther and the Reformation. So, did that affect fasting in any way? 

Steve Hendricks: Yeah, I mean, absolutely it did. It probably wasn't as big a deal with Martin Luther as people thought when he nailed his-- well, he probably didn't, another myth of history. Yeah, he didn't nail his thesis to the door of the church, but when he published his thesis, he was upset about fasting. At that time, what had happened was at the same time that there was this one poll of fasting, which was this crazy, over the top, extreme fasting that led to the fasting saints and some of the stuff we've talked about. There was also this other poll in which ordinary people were trying desperately to get out of fasting any way they could because they hated it. So, particularly if it's on the calendar a couple of hundred days a year. 

The church had eventually gotten around to letting the rich buy their way out of fasting by making donations to the church. These were called dispensations and you could buy a dispensation to let you drink milk or eat butter or something during your days when you were supposed to be fasting. There's even one of the Cathedrals in France in Normandy has a Butter Tower. It's called the Butter Tower because this gorgeous Gothic tower was built on the money from the dispensations for laypeople to eat butter during Lent and other fasting days. So, Martin Luther didn't like all that, but he didn't make a huge deal out of it right there and then in his original protests. But he eventually became much more vocal as he was criticizing the pope in Rome and other members of the hierarchy of the church. He eventually went after them for these dispensations. 

Not only were they unfair to people who couldn't afford them, but who were these humans in Rome to be selling off something that was supposedly God's right to tell us to do or not to do? And so, from there in the Reformation, fasting played a pretty large role in getting people to revolt against the church, because fasting was something that was hated. The church was corrupt, it had tons of money, and rich people could get out of it. So, you had a lot of very ordinary people who were very primed by fasting to revolt against the church, which eventually led to the establishment of all these Protestant churches in countries across Europe. 

Melanie Avalon: Yeah, one of themes I found so interesting is the backlash and the responses surrounding fasting and especially politically or even with the government and things like that. And so, in the US, there were quite a few interesting people. I was wondering if we could talk about Bernarr Macfadden. I was so fascinated by him and what he did and this idea of the cult of the Body Beautiful and everything that happened with him. So, how does he relate to the fasting world? 

Steve Hendricks: Yeah. Bernarr Macfadden stumbles onto the scene about 20 years after Henry Tanner's fast in 1880. Macfadden was perhaps one of the greatest showmen in America. And I don't mean that literally. Well, he did do some shows on stage, but I mean just sort of as a carnival like media figure. He came along and in 1899 established a journal called Physical Culture, which by the time it was done with its first year, had 100,000 subscribers, which made it one of the biggest subscribed journals in the country and would just keep growing and growing. I think the number between the two world wars was that it sold 50 million copies. What Physical Culture was, was this Body Beautiful magazine. It showed people who exercise, exercise wasn't huge back then and lifted weights, which was even less huge, and he would show them what they could make of their own bodies and that was its power. 

It was like everyone has the power to be as beautiful and handsome as these models, who, not incidentally, he showed wearing next to nothing, sometimes wearing absolutely nothing. With the genitals artfully concealed behind a literal fig leaf or something. And so, he gained this enormous enormous following. He created one publication after another. It was kind of the beginning of this confessional, first person, lurid stories that played fast and loose with the truth form of so-called journalism. Some of his other publications were like, True Detective, True Romance and stuff. Supposedly the stories were true, but of course they weren't. At the height of his powers, with all of his journals and he owned a newspaper or two. He had a circulation of 200 million copies a year in a country that didn't have anywhere near the number of people who we have today, of course. 

He made all kinds of fantastic health claims. Like he had a way of regrowing bald heads, regrowing the hair on the heads. He had a way of one of the most famous was a thing that he called the penis scope, which was this, like, glass tube and a vacuum pump. It was supposed to give these middle-aged men with erectile dysfunctions like firmer erections. I mean, just crazy, quackery, nonsense stuff. But in the midst of all this, he also put out some really useful information about fasting, because he had discovered fasting when he was a child, probably had heard about Tanner's fasts and so on. But he had noticed, working on a farm that farm animals, when they got sick, stopped eating. So, one time when he got pneumonia, he tried it and believed that it had helped him. He did all of these very important things, but very poorly respected things because of who he was to promote fasting. 

He wrote books and there were articles in his magazines about fasting and he supported various fasting doctors and so on. It didn't take because he was such a quack on so many other things that the medical establishment absolutely wanted nothing to do with him, and he just blasted them left, right, and center in his publications. But it had so very little effect. What he did do, however, was to carry forward and not just carry forward, but expand on Henry Tanner's bringing of fasting into the public consciousness because what Macfadden did was he actually showed-- I'm not talking in any scientific way, but he would report cases of people who claimed to have been cured of their diseases by fasting. People who had skin diseases, headache, constipation, kidney diseases, on and on and on. It's a very long list. This sparked the curiosity of a very small number of doctors and scientists and sort of more judicious reporters than he was, who took fasting to the next step. But he's an enormously important transition figure. 

Melanie Avalon: So, fascinating, it just makes you realize you just don't know what's going to have an effect. I'm blown away. You said 200 million copies a year. 

Steve Hendricks: Yeah. 

Melanie Avalon: And today, there's only like 300 million, I think, citizens. 

Steve Hendricks: Yeah, we've got, I don't know, 330 and 340 million people here. So, yeah, these were-- one person might be getting five of his journals. It's not like it was going to 200 million people. That figure was in 1929 right before the Great Depression struck. He went downhill from there. But even as late as oh, I forget what the year was, early 1950s, let's say. There was this famous show, TV show, where you had to guess a famous person based on just a sentence that they read or something like that. I'm forgetting what the name of it was. It was really catchy, but anyway, 30 years after his peak, 20 years at least, he could appear on this TV show without his face showing, just his voice reading one line or whatever it was, and people could guess who he was. He had that much influence over the culture. 

Melanie Avalon: And he started his own religion. 

Steve Hendricks: He did. [laughs] He started it, had to be one of the shortest-lived religions in history. He started something called Cosmotarianism and Cosmotarianism was just a blend of Macfadden health doctrine and kind of some parts he had stolen from Christianity. It must have lasted six months or something. 

Melanie Avalon: Speaking of Cosmo, I learned about, I guess Cosmopolitan magazine used to be different than it is today. 

Steve Hendricks: Indeed, it was a serious journal that talked about, I don't know, gosh, the economy or the state of the French Army or what have you. It was not a sex tips and blemish free skin kind of journal. 

Melanie Avalon: There's another theme there that I think we see today, not specifically fasting, but even today, you just don't know what's going to take off, what's going to become popular, even with people who might have celebrity attached to them. You don't know if what they promote will be successful. So, I was super interested to learn that, like, Upton Sinclair, for example, who most people have heard of and are familiar with, that he wrote about fasting. 

Steve Hendricks: Yeah. He was really the next, I think, most important person after Macfadden. Upton Sinclair is the famous muckraking journalist, who when he was in his late 20s, wrote a book called The Jungle and was about the atrocious treatment of workers in Chicago meat packing plants and also about the completely unsanitary conditions there. But he had a much lesser known side to him and that was that he wrote a book called The Fasting Cure, which grew out of a couple of long articles that he had written for Cosmopolitan magazine back in 1910 and 1911. What Sinclair had a story about, like, a lot of people who come to fasting, which is, “I had all these illnesses. I couldn't shake them. I went to doctor after doctor after doctor.” I mean, he spent gosh, I think, translated into today's money something like $500,000 on doctors and sanitariums and retreats and so on, trying to cure himself of what sounds like a really unshakable fatigue, constantly upset stomach, headaches that would strike him out of nowhere and no one had any cure. 

Then he stumbles on some of this crazy stuff from Bernarr Macfadden and he tries fasting. To make a long story short, it cures him. All of his ailments go away. He is able to write more prolifically than ever, and he says, “Well, I got to tell the world about this. I've got a platform, so let's get the news out.” What he did that was very, very useful. In addition to writing these two articles for Cosmopolitan, he also put out a survey. I think it was at the end of one article and said, “Hey, if you have fasted, if you're reading this, would you please write and tell me whether you had a good response, bad response. Tell me if you were fasting to cure something. Did you cure whatever it was?” So, he did the first really sort of systemic attempt, and he's a layperson. He's not a scientist. He's publishing in something that ordinary people need to be able to read or his publisher will not sell it. 

As good as a layperson could do a very good job of assembling a whole bunch of case studies of people who said, “Yeah, I had a stomach ulcer, I fasted for 35 days, it went away, or, yeah, I had thus and such wrong with my liver or thus and such had a carbuncle on my toe. After a fast of 20 days, it went away.” What he was doing was he was saying, “Look, you don't have to take my word for it.” He provided the names and addresses of these or at least the cities that they lived in, which back then was good enough. He would provide information about these people and just say, “I just want men of science.” They were almost all men back then, of course. “I just want men of science to look at this seriously. It surely cannot be that we have all this evidence of all these people, more than 100, 90% of them, who said they got better when they fasted. It surely cannot be that we have all this evidence and scientists will not take a look at it, particularly because at that time medicine could not cure most diseases. It was really still a very impotent form of medicine back then. But of course, as you might have guessed, that did not happen. Scientists generally looked away. Most men of medicine looked away. 

Melanie Avalon: That's something I found so interesting. You talked about how when they really first started studying fasting for longevity, and it was a lot in rodent studies, I think, probably in the 1980s, but I think you made a comment about how there was all this really fascinating research on longevity and telomeres and shrinking organs and nuclei and stuff, but it took so long for people to apply that to humans, like to do human studies. Why do you think that is? 

Steve Hendricks: Yeah, again, it just goes back to how counterintuitive fasting is. It is just very hard for people to accept that not eating can make you stronger, that it can heal you. If we have it our sort of textbook ideal version of what a scientist or doctor is, as someone who's entirely dispassionate and doesn't have any biases and can look at things completely fresh every time, “That's not what's going on.” Doctors bring their biases. Scientists bring their biases just like the rest of us. Boy, I mean, I'm telling you, it's still a hard sell today, trying to convince doctors about this. In 1950, oh, my gosh even harder. 

To the point where I tell the story of this one study that this pair of scientists, this odd couple of scientists at the University of Chicago does about that time. It's somewhere in the ballpark of 1950. I don't remember the exact year. They find that when they fast rodents, they live vastly longer and they almost completely eliminate, I believe it was breast cancer was the one that they were looking at in these rodents. They had various groups of rodents and I'm saying rodents because I don't remember off the top of my head whether it's mice or rats, but they had various groups.

One, they fasted every other day. The other group, they fasted every second day. Another group, they fasted every third day. Then there was a control group that ate normally. Well, the one that did the best was the one that fasted the most. All right, but it turns out that those mice ended up being much smaller. They didn't grow to full size. Now, we now have the science to know that's because our growth hormones and our growth mechanisms are intricately involved in our longevity markers. You can grow more slowly and be smaller and live longer, or you can grow fully and eat as much as you want and stimulate your growth hormones and not live as long seems to be the message. But they didn't know that then. So, what did they see? They saw, “Well, hey, look, fasting seems to be able-- well, it certainly makes these guys live longer, almost practically eliminates one of the most dreaded forms of cancer.” 

But guess what? There's a problem here. They don't grow to full size. And they could not reconcile that. They could not recommend to people, “Hey, we might have a cure for cancer here or something close to it, but you're not going to be as huge and big and vigorous and so on as you might be.” So, they played down their own finding and played up one of the other lesser fasting groups who fasted less often and got fewer benefits and so on, because you wouldn't be hale and hearty and strapping if you've-- and I'm like, I shoot, I would trade two inches for 20 years of life. [laughs] It's not even a question for me, but it's a very, very difficult thing for people to accept. Again, just another aspect of it being so very counterintuitive. 

Melanie Avalon: It's also similar to this idea about the assumptions that they make on the findings and what people would want or willing or not willing to do. You talk about the role of advances in epilepsy and the keto diet and fasting, and then this recurring theme where basically, I'm going to say they say but they say that it's too hard to fast to address epilepsy. So, it's not even presented as an option to patients or to parents who have kids who are epileptic. They aren't even exposed to this thing that could possibly really help their children because it's just assumed it would be too difficult, which is very, I don't know. It's frustrating. 

Steve Hendricks: Yeah. You can understand where it stems from. I mean, you have doctors who have a very short amount of time with each patient, and they're supposed to tell them what exactly in their eight minutes of contact with the patient, “Hey, guess what? Your diet is terrible, so you need to completely overhaul your entire diet if you want to live longer.” The few times that they try to do that or you've got eight minutes with a smoker and you're trying to tell them how to quit smoking. That smoker has 25 years of smoking behind her, and she is not going to hear what you have to say in eight minutes. So, they get this impression that's not completely undeserved of. Look, when we give some kind of advice, not all advice, but when we give some advice, it is very hard to get people to follow it. 

It's hard enough when it's like, you could try eating less processed food or you could try stopping smoking, which everyone agrees with. Gosh, if you're telling them something crazy like, “Hey, how about fasting?” [laughs] What are the odds that they're going to be able to adopt it? I think it is true that if you only have a few minutes with a patient, the odds are very, very slim. However, that's the problem of the medical model. It's not a problem with fasting and it's not a problem with patients because there are a lot of patients who, if you said in those seven minutes or whatever, “Hey, I think you should really try fasting, I don't have time to go into it all with you. Here's what I can tell you in five minutes, and here are some books and websites and so on that you can go and look at, podcasts you can listen to,” and that might actually have some kind of effect, but most doctors aren't thinking that way. They're thinking very, very short term.

Melanie Avalon: Something I wish we could do. There's an issue surrounding it because I don't know if it requires deception, maybe it doesn't. I wish there could be a system where there could be a pill that's a placebo pill and it's a fasting pill. And the directions for taking it is you take this pill, but you can't eat a certain amount of time before or after. So then, you can give them the pill, but really you're just forcing them into a fast. 

Steve Hendricks: Yeah, that's great. You have hit upon exactly what some of the United States is anyway, earliest fasting doctors came up with in the early 19th century. One of the doctors I write about, Isaac Jennings, who was this doctor in Connecticut, noticed that people seemed to get better when they stopped eating and noticed that they did better than with the so-called medicines that he was giving them, which were just almost completely useless. So, he did that. He tried an experiment where he created bread pills. He just made pills himself out of flour and water, colored them to make them look like the pills that you would buy from the apothecary and so on, gave them to people and said, your instruction is to take this pill, drink nothing but water, and I'll see you in three days. The results were convincing enough to him that he simply stopped prescribing medicines about 98% of the time and simply prescribed these placebos and then eventually felt bad about it and told his patients about it. He thought for sure that they would run him out of town. So, he had set up. 

Melanie Avalon: But they did it, right? 

Steve Hendricks: No, they didn't. They took it really well and he stayed there in Connecticut for another several years and then eventually went off and practiced in Ohio. But, yeah, it seemed to have worked. 

Melanie Avalon: How do you feel about Valter Longo and his approach to fasting and his choice to go the fasting mimicking diet route? I think a lot of it probably involves a lot of these reasons and forces at play as to what you can actually do and get funding for and prescribe to people and make actionable. 

Steve Hendricks: Yeah. So, I think, Valter Longo, who's a professor scientist at the University of Southern California, I think he's fantastic. He has done some outstanding work. I do have some criticisms which I mentioned in the book, but I understand why he's gone the way he's gone. His big breakthrough, he's had a lot of big breakthroughs. There are people who are pushing him for a Nobel Prize, and he would certainly have my vote if I were on the committee. But one of his big breakthroughs was in fasting for cancer treatment, and he had this terrible experience. What he basically found is that fasting can weaken cancer cells and it can protect healthy cells. So, it weakens the cancer by starving it out of its preferred fuel glucose and shutting down the growth factors that cancer hijacks to spread and divide and increasing the immune cell activity of these cells that go around and zap our cancer cells. 

Meanwhile, the healthy cells bunker down. They go into a protect and repair mode. So, when you give chemo or radiation and you fast people during that, the healthy cells either ignore it or if they get dinged up a little bit, they're great at making repairs. So, in human trials, he found that people had less nausea, less vomiting, less headache, less fatigue if they fasted during their chemotherapy. We know that's for sure in humans and then in mice what he has seen is that the cancer cells that are weakened, more of them are killed by the chemo or the radiation, so more of it dies. And because the healthy cells are protected, you can ratchet up the chemo and the radiation, you can kill more of the cancer. There are human trials going on now to see if that part of killing more cancer is also true in humans. We know that the protecting you from chemo side effects is true in humans. Okay, so I go into all that to say that's amazing.

Melanie Avalon: Right. [laughs] 

Steve Hendricks: He has found a way to make chemotherapy less miserable and to make it more potent. So, he takes his findings, which at that point had been in mice, to oncologists at these various hospitals that participate in research studies all over the country and says, “Hey, would you enroll your patients in my fasting trial? Here's what I got. It seems extremely promising,” and it should have taken them about two years to get all the people do the trial, get the data written up and all that. It took them like, five years, and the main reason was because oncologists said no. Many of them just wouldn't take calls from his lab because they thought this was just sheer quackery. They didn't want their patients fasting because patients lose weight on chemotherapy, and so they were afraid that they were going to get too skinny. 

Okay, that makes total sense. What Longo told them was, like, “Look, in my mice and in these human anecdotes that we have, people actually don't lose much weight because they're not as nauseated from the chemo. But even the ones who lose weight, they gain it right back in two or three days when they refeed. This is not a problem.” But oncologists could not hear it, and so Longo decides, “Ah, crap, fasting is just a dead end. I'm not going to spend my whole career beating my head against the wall. I'm going to instead try to see if we can come up with a diet that mimics fasting.” I'm sure you've discussed this on your podcast more than once, but so his fasting-mimicking diet, he actually came up with two.

One for kind of more healthy people to use and one for chemo patients to use. Oncologists have, in fact, proven much more willing to use that. And for that matter, for the healthier people who don't have cancer, but maybe they have prediabetes or high blood pressure or whatever, other doctors have been very excited to do that. They say, “Oh, so we can give our patient a little bit of food and still get most of the benefits of fasting.” Probably not all of them, but most of the benefits, great. So, that's really good. I think that's fantastic. 

Here's the problem. My problem is that in a world where science wasn't controlled by what you can sell and instead was controlled by what's best for the patient, we would have trials that put the fasting-mimicking diet head-to-head against water-only fasting. And we would see which one does best and then people could have a choice. Look, not everyone wants to fast, even when threatened with death from cancer. But if you knew let's just speculate here that if you did the fasting-mimicking diet during your chemo for your cancer, your odds of survival jumped from 3 years to 15 years. If you did water only fasting, they jumped from 3 years to 25 years. Well, you could make an educated choice about what you wanted to do. 

Unfortunately, no one's going to pay for a randomized controlled trial to compare fasting with a fasting-mimicking diet, because you just can't make much money off of fasting. Fasting-mimicking diet is something you can sell. They go for about 200 bucks or so for a five-day package. It's not like a ton of money, but that's money that people, investors can invest in and so, we're getting trials on the fasting-mimicking diet, which are great, but they're not being compared for the most part maybe at all, to fasting, which I think is a real shame. 

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I would hypothesize if they suspected that the fasting-mimicking diet would outperform fasting, that they might.

Steve Hendricks: Yeah, I mean, absolutely. What is their incentive to prove that there might be something better out there than the FMD, right? 

Melanie Avalon: Yeah. Have you done ProLon?

Steve Hendricks: I have not. I've been curious about it, but I have never done it. 

Melanie Avalon: I ordered it. I was going to do it. It was a no go for me. When I'm just doing water fasting, like, not eating, I'm good, but having to eat like a tiny small amount of food, it just makes me ravenous. I think I tried like one day I was like, “no.” 

Steve Hendricks: [laughs] Yeah. People tell me that you get used to it, but yeah, I have wondered the same thing as to what it does for your hunger. Doesn't seem likely to be great. On the other hand, it's only four or five days. 

Melanie Avalon: Have you watched, was it Gwyneth Paltrow's Goop Lab on Netflix? 

Steve Hendricks: I have not watched it. 

Melanie Avalon: She has an episode. One episode is with Dr. Valter Longo and she does ProLon. And then one episode-- was it the same episode? I think she also interviews Dr. Alan Goldhamer, I think. So, fasting clinics today, what was your experience at TrueNorth Health Center like? 

Steve Hendricks: Yeah, so TrueNorth in Santa Rosa, California, which is about an hour North of San Francisco, is America's oldest and largest fasting clinic. There are only like three in the entire country. The other two are just kind of sole practitioners or in one case a husband-and-wife team who see a handful of patients a year. At TrueNorth, they've got 70 rooms, they're seeing 1500 people. Inpatient who are coming there to fast or to eat a vastly reduced diet all year long. They have an enormous amount of experience. I will say, as positive and glowing things about Alan Goldhamer as I said about Valter Longo. He has been a pioneer. He, for the longest time, was the only place you could fast under medical supervision in the United States. He kept fasting alive in this country at a time when it probably should have died, but for his persistence. 

Best of all is that unlike previous fasting doctors, Herbert Shelton, who did an awful lot of good, a fasting doctor of the 20th century, the most prominent American fasting doctor until Goldhamer. Shelton was not very scientific and didn't have much interest in having anything to do with science because researchers had so strongly rejected everything that he practiced and preached. So, what Alan Goldhamer said, however, was very early on in his career, he's been fasting people since 1984, I think he's 62 or 63 now. He said, “Look, if fasting is ever to achieve widespread acceptance, we have to put it on a scientific basis.” 

And so, from very early on, he was collecting data from his patients about how they improved on fasting. He eventually, probably about 15 years ago or so, founded a foundation to undertake research on fasting. What he'll tell you is if you go to TrueNorth, he'll say this looks like a fasting clinic. But in fact, what we are is a research center disguised as a fasting clinic. He keeps the rates there extremely low so that he can get people who will come and fast long enough to get well. He has, for the last 20 years been publishing little by little, little more each year, these scientific studies that document and validate some of the reversals of disease that he and his staff have achieved through fasting. 

Melanie Avalon: Doesn't he have the largest documented drop in blood pressure? 

Steve Hendricks: Yeah, that's truly the-- if you want both a very heartening and very sad snapshot of fasting and science today, it's that. So, yeah, his first study was one that he co-wrote with T. Colin Campbell, who is the author of The China Study, a very respected Cornell nutritional biochemist. What they found in Goldhamer's data-- So, what they did was they took, I believe it was 174 consecutive patients. There was no cherry picking. Every patient who walked in the door at TrueNorth who had high blood pressure and fasted was enrolled in this study. What they found was every single one of those people on high blood pressure, their blood pressure dropped remarkably. All of them were able to go off their high blood pressure medication if they were on it. And those who had the worst high blood pressure did the best. Those in stage 3 hypertension had a drop of 60 points in their systolic pressure. That's the top number 60 overall.

Among all their patients with high blood pressure, the average drop was 37/13 points, which, as you say, is the largest drop ever reported for any therapy in the peer-reviewed scientific literature. Anti-hypertension pill doctors are happy, you get a 10-point drop. These drops of, on average, 37 points, that's just completely off the charts. The need for this is dire because we have gosh, what is it. I think it's 500,000 Americans every year are going to die of at least high blood pressure being one of the contributing causes to their death, and sometimes the cause outright. Half of all Americans get high blood pressure. American adults, and I think it's like three quarters of us by the time we're in our 70s. 

The American Heart Association says still to this day that there's no cure. Yet we have studies going back more than 20 years showing that, in fact, you can completely reverse high blood pressure. One of the great contributions of Alan Goldhamer was-- so scientists have known casually for about the last, oh, I don't know, 80 or 90, maybe 100 years that you could reverse high blood pressure when you fast. However, when people go back to eating, their high blood pressure always went back up. So, it was kind of thought of as a party trick or something. But what Goldhamer did was-- what a bunch of other fasting doctors did, which was just to ask the simple question, “Well, if the disease goes away when we take the food away, was there maybe something in the food that was contributing to the disease?” Like so many other doctors, fasting doctors throughout history, he read the science and experimented with what kept his patients' diseases away. 

He settled on a practically unprocessed, certainly minimally processed vegan diet. It's so unprocessed, he doesn't even use added oil, salt, or sugar. But by doing this, he did something that no previous doctor had ever achieved, which was keeping his patient's high blood pressure away when they went back to eating. So, we have what seems to be a cure for high blood pressure. There have been multiple follow-up studies that Goldhamer has done. The most recent one was done with a researcher at the Mayo Clinic and it was published in a fairly well recognized and prestigious journal. The catch is these studies are not randomized controlled trials. Now, you could conduct a randomized controlled trial, I don't think you'd find anything different. I think you'd find the exact same thing. There's almost nothing in these studies that suggests that these are anything other than legitimate findings, but you can't be 100% certain with something like this unless you do an RCT. 

The problem is those are extremely expensive to conduct. And so, TrueNorth hasn't conducted any randomized controlled trials because they can't afford them. The government's not giving money to people like TrueNorth to do fasting research. Of course, who else is funding it? Big Pharma, big medical device companies, so on. They're not putting forward any money for fasting because they can't make any money off it. So, sadly, although this cure possible, probable I would say cure is out there and known in the scientific literature, it's been almost universally ignored.

Melanie Avalon: It's crazy because not only is it ignored and there's all these forces keeping it from being studied and happening, on top of that, you talk about the issues he's encountered, which people trying to shut him down and the authorities, and that happened a lot historically with a lot of these different people. So, it's just very interesting. How was your experience? How long did you go there for? 

Steve Hendricks: Yeah, my wife and I, in I believe it was June of 2021, we went there for two weeks. So, when you fast at a fasting clinic, they typically will fast you for however many number of days, and then you need to stay there while you re-feed because your re-feeding needs to be carefully calibrated and supervised. You stay there half the number of days you fasted. I think we fasted nine and a half days and re-fed for four and a half days. 

Melanie Avalon: Yeah. Speaking of that, I love how you hacked the German clinic situation by-- didn't you fast before so that you could get a longer fast there? 

Steve Hendricks: Yeah, so I went there in part because I was having some health struggles that I hoped to correct. What almost all fasting doctors have found for the last, let's say, 200 years, is that longer fasts tend to better than a series of shorter fasts. However, if you don't have the time or you don't have the money, because some of these places can be quite expensive, they say, well, the next best thing would be to do a shorter fast. So, actually, before both of those, before I went to TrueNorth and before I went to the Buchinger Wilhelmi Clinic in Germany, fasted for I think it was maybe five days or so on my own water only, and then re-fed for a week or something, and then went to the clinic and fasted there for 9 or 10 days. 

Melanie Avalon: Just speaking of listeners are going to have to get your book and hear your experience, particularly at that German clinic and like with the enemas and colonics and things like that. It's really funny. It's really funny. You tell the story really well, your experience there. So, wow. Well, this has been so amazing for listeners. We only barely touched on everything that is in this book. There's so much more. I will just direct them to the book. Things like we didn't even talk about circadian rhythm and a lot of the studies today and things like that. So, listeners definitely have to check it out. The artwork on the book, why did you choose the leaf? 

Steve Hendricks: Yeah, so I didn't choose it, but I did approve it. It was something that the graphic designer came up with. But the reason that it was chosen and the reason that I like it is it's symbolic of fasting. It's a leaf for people who haven't seen the cover. It's a leaf that has, a fall leaf. It's changing colors. So, you have in this fasting, some symbolic kind of almost like dying, where we're not eating, we're not getting nourishment, our body is bunkering down in a way that's not part of our normal go getter active kind of life. But from this comes a rebirth. We don't have the whole tree here and we're not seeing that eventually it's going to grow new leaves having shed this old leaf. But I think that's why the artist chose it and certainly why I like it. 

Melanie Avalon: Oh, I love it. I knew there was something behind it. It's a beautiful book, by the way. I have it right here in front of me. 

Steve Hendricks: I think they did a very nice job with the design. 

Melanie Avalon: Yeah, it's amazing and very substantial [laughs] as listeners have not figured that up by now. So, maybe one last question about everything. This book and this work was the history of fasting up until now. What do you think the future of fasting will look like? 

Steve Hendricks: That's a really good question and I'm not sure. One of the biggest discoveries to me-- I got really deeply interested in fasting. I mentioned coming to fasting to lose weight and so on, but I've stuck with fasting and I'm most interested in it because of its ability to heal, its ability to reverse diseases that we do have and prevent diseases that we don't yet have. What I have found in the couple of months since the book has been out and talking with people is most people just aren't interested in that, which really surprises me. Most people are either-- the two biggest reasons I get are one, I want to lose weight, which is great. Nothing wrong if you have excess weight. You will be healthier and less disease prone if you do not have excess weight. We know that. 

But on the other hand, and the other thing that people tell me is I want to fast in order to be kind of more efficient. I want to be able to be, whatever, a better CEO or a better capitalist in some way so I can go out and crush my opposition or something. But fasting can make you more efficient, it can make the mind in some cases work better and so on. It's not to diminish either of those reasons terribly. But when I try to tell people, are you interested in maybe not getting cancer or something. The interest level drops quite a bit. Going into all this, because I sort of assumed because where the research is going is for this longer-term health. The research is heading in the direction of more disease prevention and more disease reversal. That is, I think, almost certainly where the science is going. It's looking at how can we use fasting to stay healthier, not just lose weight or be mentally tougher or whatever it is. 

However, that's not where I at least so far, I'm finding that a lot of the public are and I'm talking about people who are interested in fasting and are perhaps fasting themselves. This junction between where the science is and where the sort of public mood is, it will be curious to see how that plays out. I kind of hope that the science-- well, I definitely hope that the science sort of pulls more people along and more people learn that, like, “Look, fasting is a long-term health-giving thing and can add years to our life if we do it right.” But whether that will happen, who knows? 

Melanie Avalon: I mean, it kind of speaks to human nature, I think, as humans we focus on what we can experience now. That would be lose the weight, feel the productivity, but we're not so good at looking at the long-term benefits. 

Steve Hendricks: Absolutely. We are very short-term thinkers, it would seem. But what surprised me is, as I say, I got into it for the losing weight thing. I don't think there's anything wrong with that. I think it's fantastic if you have some extra weight you want to shed and so on. What surprises me is that once you're in it for that then trying to say, “Hey, so now that you've done it and seen that it's doable doing this somewhat periodically, whether daily intermittent fasting or whether prolonged multi-day fasting, it could help you.” Yeah, I've yet to see an overwhelming interest in that. Maybe my book will be a small nudge for some people in that direction. 

Melanie Avalon: I mean, longevity science is what I'm obsessed with. I would say I do fasting for the longevity benefits primarily, but it even for me comes back to now. I think I do it now because I want to feel younger now. I think it makes me-- the focus is always on the present, I think. So, yeah, it's really interesting. So how do you practice fasting now? Do you do it daily? 

Steve Hendricks: Yeah, so they're basically speaking two types of fasting. There's the prolonged multi-day fasting, which is mostly what we've talked about, and I do a fast of about one week twice a year. But I think the most important one is actually the daily fasting. And I do, do that. It was not something that I did before doing the research on this book, but I became extremely interested in it. We're probably running out of time here, but I'll just tease your listeners with the surprising thing that the research has found is about daily fasting. I mean, just in the last like three, four years, this is really new stuff. 

One piece of it is not news at all. It's that if we eat in a shorter window each day and we fast for longer each night, we increase the amount of repairs. A lot of people know this. That's why you have these 16:8 eating patterns and so on, where you're eating in an 8-hour window and you're fasting for 16 hours a night or whatever, that's great. What a lot of people don't know is they tend to usually do that by skipping breakfast and then they put all their food in the afternoon and the evening. It turns out that our circadian rhythms have just hardwired us and there is virtually nothing, it seems that we can do to change this. 

We process nutrients far better and we end up being far healthier if our window is in the morning, if our eating window starts an hour or two after we wake up. For a lot of people, where the science is pointed is it seems like the healthiest eating window out there is probably from, let's say 08:00 AM or so to 02:00 PM. And the thing that I always hasten to add after that because that completely freaks people out. I mean, I hated hearing it. I was a late-night eater. I was a breakfast skipper before working on this book. I just thought this was the worst news in the world that I had come across. I've actually found that it's just really not at all difficult for me to do. I have more energy. I would not go back to eating the way that I did before. Now that I'm eating one of these sorts of 8 to 2, 9 to 3 eating windows every day.

But there is a compromise for people who still want to eat dinner. It seems the science seems to be pointing to the fact that if you put most of your calories in the day in that early window, so that means a bigger breakfast, bigger lunch, and then keep dinner light and early, you can probably get most of the same benefits as someone who's eating just entirely within that window. So, it turns out that the adage that was coined in the last century to eat breakfast like a king, lunch like a prince, and dinner like a pauper actually turns out to be pretty good advice. There's a whole chapter on how the science came to this and hopefully I've presented it in a convincing way because I think it's very good science. It's very convincing, it is extremely counterintuitive, but that could be contributing to a lot of our bad health. The fact that so many of us are eating late and eating big late. 

Melanie Avalon: I was really excited to read that chapter, especially because I am haunted by this question. Well, first of all, just my own biases. I gravitate towards eating late at night as like a person, historically, I always have been. I get so many questions from listeners all the time about this, about early versus late eating. And so, a few months ago, it was longer than that. I was like, I'm going to try to just read everything I can read and be as unbiased as I can and see what I think it shows about early versus late night eating. I thought it was going to be hands down. Early eating was the way to go. What I felt looking at everything and I mean, we could talk about this for hours and there're so many studies, but I felt like from what I saw that probably late afternoon to early evening might be the most beneficial window just hormonally if looking at the hormonal profiles. 

But some of my concerns or my things I'm curious about is the role of bias in breakfast eating studies and then the healthy user bias that we've been told for so long that eating breakfast is healthy. It's hard to separate that. So, the people who eat breakfast are probably more often doing healthy lifestyle habits. And then a third piece was the lack-- I wish there were more studies directly comparing because there aren't many. I tried to find as many as I could, but there aren't that many that directly compare an early window to an evening window, both completely fasted and a short window. 

Steve Hendricks: Yeah, I agree with you. There's definitely a shortage of studies out there. And you're right, breakfast skippers, I was a breakfast skipper for 50 years, [laughs] lumping myself in this category, but breakfast skippers tend to be less healthy. I mean, I'm not talking necessarily about people like you and me, Melanie, but I'm talking about alcoholics will skip breakfast because they're sleeping through breakfast. Smokers will skip breakfast because the cigarette suppresses their appetite. People who are overweight and obese and therefore less healthy, by definition are often skipping breakfast because they're trying to lose weight and some of them binge later in the day. And that's all to say. There are all these confounding factors that scientists try to control for, but there's no perfect study out there that controls for all those perfectly and ends up with the conclusion, yeah, breakfast skipping is unhealthy. 

But I try to present what I feel is the preponderance of the evidence that is saying basically breakfast skipping is unhealthy and with enough detail that the reader can make up her mind about that herself. The one thing that I would say is I don't know a single researcher who has looked at these early time restricted feeding windows. So, you're eating whatever from 08:00 AM to 02:00 PM, rather than eating from noon to 06:00 PM or 04:00 PM to 10:00 PM or whatever it is. I don't know a single person researching the field who wanted to find the answer, “Oh yeah, dinner is bad for you.” [laughs] So, the fact that they have consistently found this answer and there aren't like a thousand studies on here, we're talking a dozen or something, that they've consistently found this. You're right, there haven't been perfect head to heads on all of these, but I think the balance of the evidence has really shifted. 

If you go to my website, which is stevehendricks.org, there's a Frequently Asked Questions page, and I focus in that chapter on one really, really very well-done study by a researcher at the University of Alabama, Birmingham named Courtney Peterson. A question that I've gotten since then is, “Do you have anything other than just Peterson's studies? Are you just relying on her two, three studies that you talk about in the book?” At the time that I wrote about it, I didn't feel that there was a lot of fantastic science out there that was as good as hers that merited taking up the space. But on my website, on that Frequently Asked Question page, I discussed three or four other studies. Most of them have taken place in China. They seem to me, anyway, to be very well conducted and very well controlled. They do do some head-to-head stuff. 

If we have someone eating from, let's say, 07:00 AM to 03:00 PM or something and then we have another group of people eating from noon to 08:00 PM. Who does better? And they're tracking longevity biomarkers and they're tracking disease biomarkers, everything you would expect, cholesterol and blood sugar and things like that. It's just to me, anyway, it just reads really overwhelmingly in favor of these morning eating windows. But having said that, the science is still young. Who knows what we'll find? What does seem more and more clear, though, is when they compare to really late eating windows, like the one meal a day, just being dinner. You're eating from, let's say, 06:00 to 08:00 PM or something. Those really seem not to pan out on a great many of the longevity markers. You might look into some of those and see what you think. Shoot me an email, tell me if you agree or disagree. 

Melanie Avalon: Just some brief comments. One, I think you did a really excellent job of, like you said, laying out all these different studies and acknowledging when there are conflicting findings. It was a very, very valuable chapter, and I think everybody should read it. I know so, what I don't think that's ideal at all. I wish I wasn't like this. I do think, though, if it's between eating all day, if you are a late-night eater and you had to choose between eating all day or having a late-night window. 

I mean, I know you had the Matson study that compared like a 5 to 9 window to an all-day eating and didn't seem to find benefits. What I'm trying to say is I think finding the fasting window that you can stick to and do consistently might outweigh forcing yourself into a different eating window that is not as enjoyable or that you can't stick to as easily because it's not what you thrive on. 

Steve Hendricks: Yeah, I think we don't have enough studies to say for sure, but I think what you're proposing there is entirely possible. It could be that, yeah, it's healthier to do a long fast each night but eat in the morning and early afternoon. But compared to eating all day, it may in fact be pretty healthy by comparison to do what you're talking about doing. So, that's entirely possible. I don't think we have enough research to prove it or disprove it. The one thing that I will say is, again, I was one of these people who I mean, my favorite countries in the world are like to visit are Spain and Italy. That's because they eat and drink till all hours of the night. That's my preferred lifestyle. I have always been a nighttime person. I did not want to make this change, but I thought I would make the experiment. 

I was just stunned in three days, all of a sudden, this 50-year-old habit of mine of eating dinner at night and eating well late into the night with bedtime snacks and so on, it just vanished. It just absolutely went away as though my body had been, as I say in the book, waiting for me to do this all along. It just felt so natural. The research shows if that is in fact something like what's going on, it's probably because I'm eating now more in sync with what my circadian rhythms are asking me to do. So, the one thing I would say is, try it for a week, see what you think. If you get a week where you can do it, try amending it, try playing with it. And you're right. Like, different people will come to different conclusions and they'll have different things that they feel comfortable with and different things that they can do with their work schedule and not do. But you might just experiment with shifting some of your calories earlier in the day, see what you think yourself. 

Melanie Avalon: I am all about self-experimentation finding what works for you. Before, when you're eating a dinner, were you doing intermittent fasting with that or were you just eating throughout the day and eating more at night.

Steve Hendricks: There was a period before I-- as I was starting research on this book, where I had shifted to this daily intermittent fasting and my eating window was exactly the one that I just criticized, which was I skipped breakfast. I would have my first meal around 11:00 AM or noon and try to have my last food by about 08:00 or so at night. I'd say the calories were about evenly divided between sort of lunchtime and dinnertime. 

Melanie Avalon: Okay, got you. Yeah. So, well, listeners get the book, read it, read all the chapters, and I can't wait to hear what people think. The last question that I ask every single guest on this show, and it's just because I realize more and more each day how important mindset is. We didn't even talk about you have a whole fascinating chapter on Russia and fasting for mental health and the effects on the brain and fascinating things people with psychiatric disorders have experienced historically with fasting. So, listeners will just have to get the book to read that. But what is something that you're grateful for? 

Steve Hendricks: Well, as we're recording this, Thanksgiving has just happened and more than anything else, I've been thinking over the Thanksgiving long weekend that I am grateful that I have had the opportunity to share this information with people. We didn't talk much about my own health struggles, but I really do credit some of the information that I found in this book with basically having saved my life. I'm in an awfully privileged, fortunate position that I'm able to write a book and share these ideas and hopefully help some other people the way that some of these ideas helped me. So, I'm most grateful at this moment for the opportunity to get to do that. 

Melanie Avalon: I cannot thank you enough for what you're doing because nobody has done this. I kept thinking so much when I was reading the book. I was like, I can't believe that I have been writing, thinking, talking about fasting for so long, and this is all just completely new information to me. My mind was being blown. I think you've done a huge service to humanity to compile all this information in a really wonderful read. I can't thank you enough. It's amazing. I look forward to your future book. Are you writing one now? 

Steve Hendricks: No, I'm busy with podcasts. 

Melanie Avalon: Oh, yes, all the interviews. [laughs] 

Steve Hendricks: Which is fantastic, I'm very happy to have them, but no, I've got some ideas floating around in my head, but nothing concrete. 

Melanie Avalon: Awesome. Well, I will eagerly look forward to your future work and hopefully we can connect again in the future. Again, thank you so much for everything that you're doing. Oh, yeah. How can people best follow your work? What links? 

Steve Hendricks: Yeah, so I'm not huge on social media. I am on Instagram. I think it's @stevehendricks99 is my handle. But best way to stay in touch is through my website, which is just stevehendricks.org. As I mentioned, the book is not a prescriptive book. It's not a how to about fasting, though you can certainly glean a lot of how to information from it. But I've gotten a zillion questions about how do I do this, how do I do that. My Frequently Asked Questions page probably has, I don't know, 10,000 words of answers to the most common questions I get. So, a lot of people have found that useful. If you want to get in touch, just shoot me an email. It's on my contact page. 

Melanie Avalon: Awesome. Well, I will put links to all of that in the show notes. Thank you so much again for your time. I treasure it. I do not take it for granted. And again, thank you for everything that you're doing and hopefully we can talk again in the future. 

Steve Hendricks: Thanks, Melanie. It's been a great pleasure. 

Melanie Avalon: Thanks, Steve.

Thank you so much for listening to The Intermittent Fasting Podcast. Please remember everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team. Administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs and original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week.

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