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Jan 15

Episode 300: AMA! Sleep, Whole Foods, Musical Theater, Bloating, Parasites, Botox, Anti-Aging Skincare, Laser Hair Removal, Favorite Books, And More!

Intermittent Fasting

Welcome to Episode 300 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

BUTCHERBOX: Grass-Fed Beef, Organic Chicken, Heritage Pork, Wild-Caught Seafood: Nutrient-Rich, Raised Sustainably The Way Nature Intended, And Shipped Straight To Your Door! For A Limited Time Go To butcherbox.com/ifpodcast And Get The New Year Bundle For Free Plus $10 Off When You Sign Up Today. That’s A 14 Oz Pork Tenderloin, 2 Lbs Of Ground Turkey, And 4 Top Sirloin Steaks Free In Your First Box!

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Athletic Greens: 75 high-quality vitamins, minerals, whole-food sourced ingredients, probiotics, and adaptogens in one delicious scoop! Get A FREE 1 year supply of immune-supporting Vitamin D AND 5 FREE travel packs with your first purchase at athleticgreens.com/IFPODCAST.

To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get The New Year Bundle For Free Plus $10 Off When You Sign Up Today. That’s A 14 Oz Pork Tenderloin, 2 Lbs Of Ground Turkey, And 4 Top Sirloin Steaks Free In Your First Box!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

IF Biohackers: Intermittent Fasting + Real Foods + Life

 Listener Q&A: Nicole - What’s one piece of advice you’d give to someone looking to get healthier? 

Listener Q&A: Samantha - I know you are a musical theater fan, what is your favorite musical?

BLISSY: Get Blissy In Tons Of Colors, And Risk-Free For 60 Nights, At blissy.com/ifpodcast, With The Code IFPODCAST For 30% Off!

Listener Q&A: Alani - What are your tricks for keeping your stomach from puffing out?

Listener Q&A: David - Have either of you taken a DNA stool analysis for parasites?

Episode 296: Berberine, Insulin Sensitivity, Glucose Control, Gut Health, Liver Health, Body Recomposition, AMPK Activation, Cholesterol Control, And More!

Listener Q&A: Amy - Loved last episode where you both admitted you color your hair without shame in not using cleaner options. I would be curious what other things are you willing to “bend” the rules for?

ATHLETIC GREENS: Get A FREE 1 Year Supply Of Immune-Supporting Vitamin D AND 5 FREE Travel Packs With Your First Purchase At athleticgreens.com/ifpodcast.

Listener Q&A: Damon - Laser hair removal, is it worth it?

Listener Q&A: Kimberly - What are your top 3 book recommendations besides your own?

Listener Q&A: Danielle - What is your favorite holiday tradition?

Listener Q&A: Lesley - I work at HOTWORX 24 hour infrared fitness studio. What do you think about a 3d workout? Heat, exercise, infrared sauna?

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 300 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I’m Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting and Wine. I’m here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it’s that time and get ready for The Intermittent Fasting Podcast. 

Hi friends, I’m about to tell you how you can get a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, plus $10 off. Yes, all of that incredible meat, plus $10 off, all for free. We are a bit obsessed with a company called ButcherBox, which is always in season. Some of my favorite meals that I had throughout the holiday season were fantastic meat and seafood from ButcherBox. Now with the new year, it is time to celebrate with only the very best of the best when it comes to meat and seafood that you put in your body, as well as meat and seafood that helps support our planet and the environment.

They make it so, so easy to get high-quality humanely raised meat that you can trust. They deliver 100% grass-fed, grass-finished beef, free-range organic chicken, heritage-breed pork, that’s really hard to find, by the way, and wild-caught sustainable and responsible seafood shipped directly to your door. When you become a member, you’re joining a community focused on doing what’s better for everyone. That includes caring about the lives of animals, the livelihoods of farmers, treating our planet with respect, and enjoying deliciously better meals together. I did so much research on ButcherBox, you can actually check out my blog post all about it at melanieavalon.com/butcherbox.

All of their beef is 100% grass-fed and grass-finished and they work personally with all the farmers to truly support the regenerative agriculture system. I also did an interview with Robb Wolf on my show, The Melanie Avalon Biohacking Podcast, all about the massive importance of supporting regenerative agriculture for the sustainability of not only ourselves but the planet. This is so important to me. I’ll put a link to that in the show notes. The value is incredible. The average cost is actually less than $6 per meal and it’s so easy. Everything ships directly to your door and it is so delicious. I love carpaccio for example. The ButcherBox steaks are incredible for that. That’s how you know it’s good steak when you can eat it rare like that and ButcherBox has an incredible offer for our audience.

You can get the New Year bundle for free, plus $10 off when you sign up today. That’s a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, in your first box. Sign up @butcherbox.com/ifpodcast and use code IFPODCAST to claim this offer. Again, to get a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, plus $10 off, sign up @butcherbox.com/ifpodcast and use code IFPODCAST to claim this offer. We’ll put all this information in the show notes.

One more thing before we jump in, are you fasting clean inside and out. So, when it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you what is possibly one of the most influential factors in weight gain. It’s not your food and it’s not fasting. It’s actually our skincare and makeup. So, as it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disruptors, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we’re using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream.

And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That’s because ladies, when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking. And the effects last for years. 

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That’s why it’s up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies and so much more.

You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my Clean Beauty email list. That’s at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list, so definitely check it out. You can join me in my Facebook group Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you’re thinking of making Clean Beauty and Safe Skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It’s sort of like Amazon Prime for Clean Beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. And we’ll put all this information in the show notes. All right, now back to the show.

Hi, everybody, and welcome. This is Episode number 300 of the Intermittent Fasting Podcast. Very exciting milestone episode here. I'm Melanie Avalon, and I'm here with Cynthia Thurlow. How are you, Cynthia? 

Cynthia Thurlow: I'm doing well despite navigating travel back to small airports. I was laughing/texting with you last night sharing all the insights I was gleaming being stuck in an airport for 7 hours with a long delay. 

Melanie Avalon: Yes, were talking about the food options, healthy or not, fasting or not in airport layovers, so I'm glad you survived. 

Cynthia Thurlow: Yeah, I know it's funny. I'm such an observer as an introvert, like, I just love to people watch. The behaviors that I was watching yesterday intermittently between reading a book, listening to a podcast, reading another book, binging on something on Netflix was just the behavioral patterns. I think people feel a lot of pressure to eat constantly when they're in airports, and I just find that all super fascinating. I think I was chronicling how it doesn't matter what airport I go to. I can generally get a naked burger and a salad and that's typically what I do. 

Actually, the waiter yesterday, it was funny. I got off my flight from LA and Chicago and I was like, okay, plenty of time. I have two and a half hours, I'll be great. I went to a restaurant, got my burger, read a book. I was totally by myself. I was totally in my zone. And then get to my gate and then we realized we've got, like, mechanical problems. I guess pilots and stewards, stewardesses are only allowed to fly for a certain amount of time every day because of the mechanical delay it turned into. We had a different flight crew. It was like a seven hour instead of a two and a half hour time in between flights. I was texting with Melanie and I said, and then, it's not a good sign when United rolls out the cart of snacks. And the cart of snacks was gone in about two minutes. It was amazing. People were clearly, “starving.” But it was hilarious to kind of watch all this unfold. So, I'm just grateful to be home and the fact that I got a decent amount of night's sleep, and it's my last business trip of the year, so no more traveling for a while. 

Melanie Avalon: Yeah. I feel like it definitely speaks to just how much well, A, we're inundated with food and food advertising and accessibility and also how food is really just a pastime. Like, if we're bored, I'm sure people were hungry as well. It's a comfort. It fills the gap of boredom. 

Cynthia Thurlow: Absolutely. I get that, there's no judgment on my part, the psychology behind the way people eat. That's why I always say, like, if you eat enough protein, you're just too full. Even if I had endeavored to eat the bag of Cheez-Its or Goldfish or whatever myriad of stuff they had, I was like, I just grabbed a bottle of water because I was so dehydrated from traveling that I was like, I'll just grab the water, and I'll just try to stay hydrated, and we'll just go from there. 

Melanie Avalon: Yeah, I always fast when traveling. If it was, like, that situation where it was a really long layover, honestly, I would probably still fast. I would probably turn it into a longer fast moment. Just because I don't feel comfortable with lots of food in me and trap. It makes me sluggish and--

Cynthia Thurlow: Yeah, definitely. I wore-- so people will probably be humored. Like, I've got a whole wardrobe of things I wear when I travel so that I can wear layers. So, I'm never cold, because traveling through Chicago, it was actually the airport was quite cold, which actually wasn't a problem. I was like, okay, I got a sweater. I'll just put that on. I had Spanx, like, leggings on all day because they're super comfortable. They weren't comfortable at, like, hour 18. They were definitely [laughs] when my husband picked me up, I was like, there's too much compression on my stomach and I've been doing a lot of sitting. He was like, “What are you trying to tell me?” I said, “You know how I talk about like there are specific things I wear when I travel. This is not the outfit. If I'm doing more than like 14 hours of travel, there's just too much compression on my stomach.” My stomach was like not happy with me at all. 

Melanie Avalon: I can't wear Spanx at all. That's how you don't have GI issues. 

Cynthia Thurlow: Yeah, they're definitely different. They're super comfortable actually. It's just that amount-- it would be like trying to wear like, Lululemon tights all day long and traveling. It's a lot of compression on your gut. 

Melanie Avalon: Well, speaking of--

Cynthia Thurlow: Probably TMI. This is a good segue into our Q&A because it's like there may be a little TMI today. 

Melanie Avalon: So, for listeners, we really wanted to celebrate Episode 300, quite a milestone. There're a lot of episodes, I think actually for every, well, there's only been two other 100 miles markers. So, Episode 100 and Episode 200. I think for both of those we did an AMA episode. So, continuing the tradition going to do and ask me anything. We got so many amazing questions that we're anticipating. This will probably be a part one, part two, maybe a part three. We'll see how it goes. We got so many really great questions in the Facebook Group which people should join, which is IF Biohackers: Intermittent Fasting + Real foods + Life. That's my personal Facebook group. I asked in that group for ask me anything questions and we got so many. What I did was I divided them into categories. I think we'll just alternate between more personal ones, more health and wellness-related ones. We'll just see where it goes. I have a lot of questions. I'm very excited about this. So, Cynthia, should we jump in?

Cynthia Thurlow: Yes, we should. 

Melanie Avalon: I'm thinking we might because I have, like I said, it's by categories, so I might alternate with the lifehack ones and the likes and things like that with the more health related. Here's a good lifehack that's kind of both. And this comes from Nicole. "What's one piece of advice you'd give someone looking to get healthier?"

Cynthia Thurlow: Oh, gosh. I think and it's funny, I was out in LA and I did four podcasts and pretty consistently the one for me is sleep as a foundational element to health for anyone at any stage of life. I would say really investing in high quality sleep and really starting with the foundations. Not necessarily rushing to a supplement, but doing the things that we know improve sleep quality, daily exercise, light exposure in the morning, getting off electronics, wearing blue blockers, making sure you don't eat two to three hours before bed unless you're a unicorn. I think those are the things that I really think about. I think we like to make things very complicated. I always say before you even think about adding a supplement, make sure you're doing the sleep hygiene pieces. Sleeping in a cold, dark room. I sleep with a sleep mask. I keep the thermostat at 65 degrees. In fact, it was funny when I came home last night, it was 69 degrees on our second floor. The first thing I said to my family was, “Oh, we're going to drop the thermostat because I need it at 65.” Everyone was like, “We've been sleeping at a much warmer temperature.” And I'm like, “I can't do that.” So, I would probably say focusing in on sleep first and then adding supplements if you still need additional support. How about you, Melanie?

Melanie Avalon: That's a good one. I'm actually surprised I didn't think of sleep as the first thing. Whenever people ask me what's the most important thing for me to focus on, I think I normally do say sleep. So, I'm really glad you tackled it. I was thinking on the diet side of things and I was really torn between eating whole foods not the store, but like, foods in their whole form, because that's macro-agnostic, but I just think if we just return to eating real food, that can have a profound effect on people's health. I was torn between that and fasting [laughs] surprise, but I actually think I would go the whole foods route.

Cynthia Thurlow: And I think that's really important. I am a huge advocate of saying that it all starts with food, and I see so many people that are quick to embrace the latest fad irrespective of what it's leaning into. I just remind people, if we just keep things simple, focusing in on sleep, eating as nutrient dense foods as you can, I think that's really, really helpful.

Melanie Avalon: Yeah, I obviously think so as well. I think between those two, honestly, if somebody's not addressing those two things and then they address those two things, I think the profound effect it would have on so many people's health would be crazy. You don't even have to be really specific or do like a certain type of diet, but that combined with the sleep, very powerful. 

Cynthia Thurlow: Yeah, absolutely. Keep it simple. I mean if there's one tried-and-true message that I think both of us discuss consistently is keep things simple because if we try to make too many changes all at once, it's overwhelming. It's hard to stay, I hate to use the word compliant, but that's the easiest way to put it. It's hard to be consistent when you're trying to change five things at once. That's what I think most people do. I mean, I certainly have been guilty of it myself, but pick one thing at a time and really lean into it and master it and then move on to something else. 

Melanie Avalon: Okay, here's the fun one and she addressed it to me, but we can both answer it. It's from Samantha. She said, “Melanie, I know you are a musical theater fan. What is your favorite musical?” 

So, I'll go ahead and answer that. I think I might have answered this on another AMA. This question, I always feel mischaracterizes me because my answer is musicals that, it sounds like a cop out, like, “Oh, she doesn't watch musicals because she's listing,” the one that everybody says, but I promise you I listen to so many musicals. But there's a reason that these two musicals are what they are, which is Phantom and Wicked. They're just so amazing. But then my runner ups are next to normal Jekyll & Hyde and Hamilton. I know she said your favorite, but there're so many, and then I have, like 50 million more. How about you, Cynthia? 

Cynthia Thurlow: A few of those I've seen. I grew up in New Jersey, and so my mom really prioritized taking me to Broadway, and so I did that throughout my childhood. For me, I would say Rent I loved. I mean, I still can listen to the music Wicked, I saw that on Broadway with the original cast just by complete happenstance.

Melanie Avalon: Whoa. Okay, I have a question. Oh, I have a question. Did you see it because when it first came out, it was a bomb like it didn't-- Did you see it before it got famous? 

Cynthia Thurlow: No, I saw it afterwards, it was with Kristin Chenoweth and--

Melanie Avalon: So, there was fanfare surrounding it when you saw it, because when it first came out, it did not take off. 

Cynthia Thurlow: Yeah, because it was 2005/2006 somewhere around there, because I was up there for a medical conference, and my girlfriend was like, “We should go see this play.” And I was kind of like, “Okay.” I had no idea what it was really even about. I just saw Hamilton, and I've been wanting to see Hamilton on Broadway for, I don't know, five years and with the pandemic that kind of nixed our ability to do that and that was amazing. To me, I have so much respect and reverence for people that work in the creative arts. I am not the least bit like, don't ask me to sing, don't ask me to act or dance in front of other people. I would be so embarrassed. I'd want to crawl in a hole, but I love to watch really talented people perform. I just have so much respect and admiration because it's so very different than where my zones of genius are.

As I was sitting there watching Hamilton with my husband and my boys, and I was like, “God, I feel so lucky to be in this zone of greatness.” Like, watching these really talented actors and actresses do what they do best.

Melanie Avalon: That is the exact way I feel. 

Cynthia Thurlow: Yeah. I'm the kind of person, I actually get emotional when I'm watching people when they're really, really good at what they do whether it's dancing or singing or a play. I get a little like teary. It's almost like out of total admiration that I'm witnessing their greatness. 

Melanie Avalon: Yeah, no, I feel the same and actually, I had a similar experience. I saw the original cast of Next to Normal. It was one of those things where I went in like you to Wicked like I didn't really know what I was going into and then I was just blown away. Ah, love musicals. 

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Here's another one and this kind of relates to what we were talking about earlier, “What are your tricks for keeping your stomach from puffing out? Do you use Spanx for that?”

Cynthia Thurlow: I mean, I don't generally have issues related to bloating. I'm probably blessed genetically with some of this on my own. Obviously, I no longer get a menstrual cycle, but when I did, when I was sometimes right before my period, and I would feel bloated. Spanx is great for that. There're different layers of levels of Spanx, so it's not all so constrictive you feel like you're going to die. For me, quite honestly, it's finding a balance between protein and vegetables. This is going to sound odd, but I'll kind of layer this in. When I'm eating a very protein dense diet and I'm eating cooked vegetables, I have little to no bloating, but if I go on a salad binge, like, I mean, a lot of raw vegetables, that can sometimes give me a little bit of bloat. I have to kind of moderate that. 

I got most of my bloating quite honestly from gluten and dairy. And now that I don't have those in my diet, it's not as much of an issue. But I can tell you, and I know we have a parasite question in this Google Doc that we're looking at when we talk about parasites. I will tell you about my bloating issues, but generally speaking, not a lot. I think a great deal of that has to do with dietary choices and not overeating. Like, I feel so miserable if I've overeaten or if I've eaten too much food that I just-- I know where my sweet spot is and if I'm kind of leaning into the protein and cook vegetables, I do really well. How about you? 

Melanie Avalon: Yeah, well, first thing I wrote was just suck it in. [both laughs]

Cynthia Thurlow: Well, I mean, here's the other thing before you say the next thing. A lot of people when they talk about bloating, it's really not bloating. It's because their core is not very strong. So, again, I think some of this is just probably innately how I was made. I've always had a pretty strong core and I've always done Pilates. I've always done a lot of core focused work. If you think about your rectus abdominis and your obliques and all these muscles that work together to kind of hold you in and hold you up, if they're not strong, that can contribute to people perceiving that they're having bloating, when it's really just they have muscles that need a little bit of work, if that helps. 

Melanie Avalon: So that's interesting. That writes me of two things. One, I have this childhood memory, I don't know how old I was, I was probably like nine or ten and some aunt commented on my stomach sticking out.

Cynthia Thurlow: Oh, well, sometimes kids have like lordosis and it's not even that their stomach sticking out, it's they have like a swayed lower back. It has nothing to do with the belly sticking out.

Melanie Avalon: That's what the aunt said. She was like, “Oh, this runs in the family or something.” But do you know how traumatic that is to be told that.

Cynthia Thurlow: People sometimes are thoughtless. I just don't realize they're filters off. It's like you could have said that or just not said that and we would have all been okay.

Melanie Avalon: Not to like a nine or ten-year-old, but what's interesting is, I think this is a fun little also lifehack, I feel like a good way to get a good core workout. So, I saw Trans-Siberian Orchestra recently. I realized I have my crazy concert outfit, which is like this really massive spark-- It looks like a dress, but not really because it's a two-piece, so it's like midriff bearing and then it's this massive sparkly dress. You can see it on my Instagram. It's incredible. In any case, I feel like it's a good hack to get a stomach workout if you wear something like that out, because then you're consciously holding in your stomach, like the entire time, unless you forget. But my first tip was just suck it in.

My second tip [laughs] was based on the digestion and finding the diet that works for you. For me, digestive enzymes are game changers for that. Finding a digestive enzyme supplement that works might help. Also, like Cynthia was saying finding the dietary combination a lot of people-- for me low FODMAP works really well and that keeps me not bloated. Also, oh, here's one. If you go carnivore for a lot of people your stomach will probably get very flat. I experienced that. Whenever I do experiment with a time of just meat, there's zero bloating. 

Cynthia Thurlow: Well, when and if we get to the parasite question in this episode, we can talk about this because that's how I knew something was very wrong and very, very wrong. I always say going back to an anti-inflammatory, like a real anti-inflammatory diet can sometimes be partial carnivore or carnivore for a couple of weeks can really be hugely impactful. But I always say just perceiving you have bloating is very different than looking six months pregnant bloating. There's that continuum that I think is important to identify. 

Melanie Avalon: I'm starting to think this might be like a four-part episode. It'll be like the AMA month. It'll be like January, the AMA month. [laughs] Okay, so, David, "Have either of you taken a DNA stool analysis for parasites?"

Cynthia Thurlow: Yes, multiple times. I have had parasites, more benign parasites, like Blastocystis, which is very common. Let me just back up and say, it is very common to see parasites even in first world countries. Don't think that, oh, you haven't traveled, there's no way you've been exposed. It's really more about exposure and susceptibility. I think that the really exciting story to share is my Morocco tales, because that's where I got the worst food poisoning of my life. I had probably an acute parasite issue that morphed into a fairly significant parasite issue and we believe is a reason why I ended up developing a ruptured appendix and being so sick and necessitated. So, let me back up further and say that you can have an acute reaction to a parasite infestation and then you can have chronic parasitic infections. I have had both and the second one was harder to tease out. 

But I'm grateful that I have amazing colleagues who, as soon as I told them my symptoms, they were like, you definitely have X. I kept saying, “No, no I've done a GI map and it didn't show it.” And I ended up going through a parasite expert who puts your stool, your poop in a slide and looks at it under a microscope. Microscopy, which is pretty important, and I indeed had two parasites, and I had Candida and I had E. coli. Within one dose of antibiotics, I felt like a different person. There was no question there was something wrong with my gut because I had tremendous bloating. By the end of the day, I looked six months' pregnant, which is a problem because there's no way I'm pregnant. I had horrible, horrible gas, like, distinctively bad foul-smelling gas, and I just didn't feel good.

It didn't matter how much I slept, what I ate. It was like as soon as I ate it started this whole bloating, gas, loose stools situation that went on for probably a month until I had gotten the stool results back. It was actually an expensive test that's done out of a lab in New Mexico, But for me, life changing. I didn't want to go on it. I literally had to take one day of one antibiotic to kill this thing. I was so grateful that I had something that could treat it. 

Melanie Avalon: Do you know what antibiotic it was? 

Cynthia Thurlow: As I am saying this. So, this is Giardia. Giardia is generally transmitted in water. If you have like, as an example, doesn't mean everyone has a well. If you are exposed to contaminated water or people that have Giardia and they don't wash their hands after they go to the bathroom, you can get exposed to it. So, I took tinidazole. It's T-I-N-I-D-A-Z-O-L-E. 

Melanie Avalon: Wow. It only took one and it knocks it out? 

Cynthia Thurlow: Yeah, it's like a large bolus of antibiotic. My husband had to be treated, too, even though we didn't test him. Parasites can be transmitted in saliva and sexually. I've done a lot of interesting international travel and this female physician friend of mine was adamant, as soon as I talked to her, she was like, I don't even need to test you, you have Giardia, but I didn't just have Giardia. I had another friend too, [laughs] so it was pretty disgusting. It was like literally one dose of medication and the next day I felt 1000% better. 

Melanie Avalon: Wow. That's crazy. 

Cynthia Thurlow: Yeah. Aren't you glad you asked it? I saw that question and I was like I will be happy to answer that question because conventional testing for ova and parasites does not always pick this up. Even the GI Map, which I clinically believe is a really really good test, never picked this up. 

Melanie Avalon: Yeah, that's one of the things. Because I've done parasite stool testing, I mean, probably multiple times. Honestly, I know some of them have been negative. I don't even remember if some of them pick something up. I just remember at one point I was working with a practitioner and it came back negative. But then he was like, “All your symptoms match parasites.” And he said most people have parasites. He had me do a course of Alinia, are you familiar with that one? 

Cynthia Thurlow: I am not personally, but only because I myself have not written a script for it.

Melanie Avalon: Okay. Yeah. He said that it was like a game-changing anti-parasite drug that revolutionized so many of his patients and it probably helped. It was during the time when I was at a really not feeling well place health wise, so I don't really know what was doing what, but I did do that. I also have done, I've talked about on the show before, have you taken Mimosa pudica? 

Cynthia Thurlow: I have not. I've taken a lot of stuff, but I've not taken that. 

Melanie Avalon: Oh, my goodness, Cynthia, and listeners, I know they've heard me talk about it before. Okay, this stuff, I should probably do another round of it. So, it doesn't kill anything. So, you don't get detox effects because it's not making anything angry. It's a very sticky gelatinous, something from some tree or something. The thing that's confusing about it and the reason I'm being so hesitant, like you can look it up, people have pictures. If you put it in water, you'll see that it forms a really long mucusy string. So, you end up passing that regardless. It's going to look like you're passing parasites regardless because it just looks like that after it comes out of you. But it will grab things and I swear to you, [laughs] the things that have come out by taking that were shocking to the point where I was like, I can't keep taking this is too scary. 

And that's the response. There are like groups dedicated to this basically, but it's super cheap. You can get on Amazon, Mimosa pudica and maybe I should make this someday. It's crazy, that's all I can say. It's crazy. 

Cynthia Thurlow: Yeah. I think what's interesting as a traditionally trained provider, it's always amazing to me that there are a lot of herbs and antimicrobials including berberine as an example. It's a potent antimicrobial that can be very effective at getting rid of pathogens and they don't have the same detrimental impact on the gut microbiome that traditional antibiotics do. Let me be clear, there was no other option for me. There was no antimicrobial that was going to kill what I had because it was so substantial and significant. I'm like, I will be forever grateful that I got some validation. But having said that, it's just nice to know that there's a lot out there that we're still learning about herbs and other potent combinations of different ingredients that can be very beneficial at killing off what does not belong. If you need antibiotics to kill off what does not belong, there is no shame in that either. 

Melanie Avalon: Yeah, and I think the thing I really want to emphasize about Mimosa is it's not killing anything. It's literally just physically grabbing stuff out of you. That's why people don't get the detox effects like I mentioned. That's why you can actually see an entire thing. It's crazy. [laughs] It's for parasites specifically. Yes, I agree 100% with what you're saying about. There are so many options and alternatives out there and it's nice that there's more and more awareness about it. Especially like with the berberine, people think about that primarily for blood sugar control. We talk about this in Episode 296 with Scott Emmens, I'll put a link to it. It was actually first used in 3000 BC, which is so long ago, and not for blood sugar control. They didn't even know that was a thing back then, but for gut inflammation and yeah, GI health, so crazy.

That actually reminds me of another question on here because I'm not saying antibiotics are bad, but they're definitely something where, there's a cost benefit and we don't want to be inundating ourselves with antibiotics 24/7, but we take them when necessary and they can be life changing like you said. Sort of in that vein, but not really because we don't really have anti-antibiotic rule. But this question is from Amy. She says, “I love the last episode where you both admitted you color your hair without shame [laughs] and not using cleaner options. I would be curious, what other things are you willing to "Bend the rules for?"”

Cynthia Thurlow: I'd probably say, like, if I go to a nice spa, there's an organic one in my area and I know what they use because we have conversations. But if someone takes me for a nice massage or I'm being treated to spa treatments, I do not micromanage what they're using on me because I will then not relax and enjoy myself. I'd probably say things that are leaning into pampering that are like gifts or they're just an experience. It's like I have to kind of readjust my expectations because if I start asking, then I'm going to be hyper focused on everything that's being used and that's actually not a lot of fun. I would probably say that is the other thing that I'm probably-- in that context, I'm probably very laid back versus what I purchase to use on my body at home. Very different. How about you? 

Melanie Avalon: That's so funny. When I go to massage or I get my nails done, I always bring my own stuff, [laughs] actually, and that's good for a question later. I used to think it would be cumbersome, but I mean, I have to be always doing my nails because of my Instagram and stuff like that. There's this one oil, I can put a link to it on Amazon. It's an MCT oil, basically, but it's a massage MCT oil, but it's just organic MCT. You can use it for everything. So, when I get a massage, I bring it with me and they don't care. When I get a manicure, it actually makes it cheaper because then I bring that and I don't have to get all the fancy upgrades and I give them that and I just let them use that for all of the lotion and everything and anything else massage oil wise. And then I got so excited because up until recently, I was having to have them use the scrubs that they have there, but over the holidays, Beautycounter came out with a limited edition scrub and a body polish.

Cynthia Thurlow: I have that. 

Melanie Avalon: Yeah, it's so good. So, for instance, if they still have that, because they tend to have it past the holidays stock up on it. I stocked up on it. So now I actually bring that-- It's one of the gift sets. Now I actually bring that with me to the nail salon as well. My other things that I bend the rules on, well, with wine at home I only drink, Dry Farm Wines. If I'm going out, I look up people know I do this, I look up every single wine and I find the organic ones and that's how I decide. I really want to make an app for this, by the way, so stay tuned. I should make that a goal for 2023 to get this app out there. If I am at a place and there's no organic wine, I will drink nonorganic wine. [laughs] 

I don't enjoy that, but I will. People know I do Emsculpt religiously. I love it. I am very concerned about the amount of radiation that it gives your body, but I think the benefits that I get from it as far as building muscle are amazing. I don't do it on my abs. People ask me that a lot, but I'm a little bit concerned about doing it right over my organs like that. So, I just do basically my extremities, my thighs, my bottom, my butt, my arms. And then this is a big one. This is a big confession. I'm probably going to be writing about this. I haven't done it yet, but I am contemplating doing Botox preventatively in my forehead. I wasn't going to, but I had a consultation and I don't know, I started really thinking about it, like, the preventative action of it and not having wrinkles down the line. So, I think what I'm going to do is because basically it's a trade-off of putting that because it is a neurotoxin. So, putting that into your body and the cost benefit, you just have to weigh the cost benefit, I think, of what matters to you or not. If I do do it, well, A, I'm going to do a ton of research. B, I really want to write a really epic blog post about this if I do it, because I think people will think if you do Botox that means that the rest of your skin care doesn't matter or that you don't value skincare. I think I want to kind of educate people on again. I need to do the research first, but if I proceed with this route, I want to maybe spread the word or awareness about the cost benefits of Botox and also why it's still super important to have really non-toxic clean skin care and why you might have both. So, we shall see.

Cynthia Thurlow: Yeah, and I think that's okay. I've always been very honest. In fact, when I was on Drew's podcast for the second time, we were talking in the context about Liver King. So, I'm sure most listeners know about Liver King and how he predominantly was focusing on this kind of paleolithic lifestyle and eating organ meats. God bless him, he eats organ meats, like, with reckless abandon. Like, it's fascinating. But as soon as I saw him, I remember saying to my son, who was like putting him up on a pedestal, I said you realize that guy is on a lot of steroids. 

Melanie Avalon: That's what everybody says. He denies it. Right? 

Cynthia Thurlow: Well, what came out recently was his steroids, like his anabolic steroid schedule and his stack of growth hormone and a bunch of other things. So, in that context-

Melanie Avalon: I missed that. 

Cynthia Thurlow: -yeah, I was saying it to Drew, I think it's important for people that are in the public eye that are influencers to be very, it's not like you have to disclose everything, but you should be honest. I think it's important for me as a middle-aged woman, in the context of our conversation, to say every year I do ProFractional, which is laser, stimulates collagen and elastin. I think that has a lot to do with why my skin looks really really good. I think some of its genetics and I think some of it's my lifestyle. And then I do Botox, I've done Botox since I was 38. I started doing Botox because I have always had a super mobile forehead and that's where it started. And I still do Botox a couple of times a year. I have done filler a few times. I've had it reversed as well.

I think a lot of if-- you chose to go that route and there's no judgment if you do. You want to work with someone that's incredibly talented. You should never look like you've had work. You should never look like your face is immobile. You should never look like your lips look, like this is just my personal opinion. You shouldn't look like you have massive lips and like crazy high cheekbones and just understanding. I think those products are designed to be used subtly, but I think if you see some people that are in Hollywood that are like the extremes, too much of any one thing is not a good thing. In the context of this conversation, I feel like I should be transparent and say that obviously a laser is pretty benign in terms of stimulating collagen and elastin. I don't per se have a problem with using Botox or fillers very discriminately because so much of the rest of my life is so incredibly healthy and balanced.

And to the person in my DMs recently who was giving me a hard time about the fact that I shared those things. Yeah, this is why people that are in, whether they're influencers, they're in the public eye, this is why people honestly don't want to share because they don't want to be criticized. But I don't care if anyone agrees or disagrees with that decision because to me it's my decision. With that being said, I think I would be doing the listeners a disservice if I didn't share that as well. 

Melanie Avalon: Well, thank you for sharing that and I am so enjoying this conversation. I have some quick thoughts and questions. One, mentioning the laser, is that the same thing as BBL? 

Cynthia Thurlow: So, I'm going to say BroadBand Light is different than the Brazilian butt lift because I very innocently last year said, “Oh, I got BBL.” And people were like, “You did?” 

Melanie Avalon: Yeah, you said that to me. I remember you were like, you said you were getting BBL. So, something about the next day and I was like, “Oh goodness, that's like an intense surgery,” because I think we still recorded a podcast maybe the next day. I was like, “How is she doing this right now.” 

Cynthia Thurlow: Yeah, this tells you how long I've been doing BBL. It was preceded the Brazilian butt lift, which I'm told is going out of favor according to my plastic surgeon friends, which is a whole separate tangential rabbit hole that we won't jump down. In conjunction with ProFractional, I do BBL and what it's doing is any brown pigmentation. I don't have a lot of hyperpigmentation in my skin. We do that preceding the ProFractional. I hate it. I hate both of them honestly. It's like a love-hate. I'm doing it in January, which is usually the month I do it. I hide for four days and then I feel fine. With that being said, the laser in and of itself is looking for the pigmentation helps dissolve it. If you have some brown pigmentation, the laser will identify it, it will help dissipate it, but it will actually get darker for a couple of days or maybe a week and then it goes away. 

For me, I think the two of those together have been super powerful. But, for anyone that's just doing BBL - BroadBand Light, it is not painless. Make sure whoever you're working with is like getting you prepared for that because it's almost like having a rubber band snapped against your skin. As you can well imagine, doing it once is not a big deal. If they're doing your whole face that can be painful. Just make sure that they're giving you either topical lidocaine or giving you something to make you feel comfortable. 

Melanie Avalon: Although caveat, also check and make sure your practitioner lets you use that because it was during the podcast last time when we were talking about I was going to go do it and then I put on numbing cream during the podcast, which apparently is some people let you. But, where I went to Ideal Image, which I'll say their name because I think they're the biggest. They're like the go-to place. They do not let you use numbing cream. So, do not use numbing cream if you're going to them.

Cynthia Thurlow: Yeah, and my practitioner, they put it on for you. Like when you arrive, you arrive an hour before your treatment and they put it on for you. With very few exceptions, I'm very comfortable with BBL. There are spots when they do ProFractional that are tender, like along your forehead line. It freaks me out when they do underneath my eyes and my nose is a little sensitive, but beyond that, not bad. Not bad at all. 

Melanie Avalon: I've heard that old therapy is the most painful thing.

Cynthia Thurlow: Morpheus is supposed to be very, very painful. I'm not ready, if someone were to give and actually the person I go to who trains providers all over the United States doesn't use those technologies yet, because she still feels like ProFractional has just as much benefits. But every time I see her, I'm like, “So what's the latest?” And then she'll kind of get me caught up.

Melanie Avalon: What's really interesting though, because you mentioned the laser, so I was talking with a friend about whether or not I should do Botox or not. It's funny because he mentioned people doing lasers and Botox and whether or not you talk about it on social media, it's interesting that for some reason, Botox, I think, has more of a stigma. I have literally no issue talking about BBL or lasers or that seems almost like biohacking in a way, but for some reason, Botox feels more fake. I don't know why because I was thinking about it more, it's not even affecting your skin, it's just paralyzing the muscle underneath so you're not wrinkling your forehead all the time and not forming those lines that last. So, I find that really interesting. I mean, I think you could make the argument that well, maybe not it's because you can make the argument that Botox is biohacking [laughs] but--

Cynthia Thurlow: I think you could and here's the thing, like, I just interviewed Dr. Amy Killen, who's a female biohacker physician, and she's so knowledgeable and offline we were having discussion about some of the things that she does. She's very transparent and that's why I hope to be just as much for listeners so they can kind of get a true sense, like some of this is genetic, some of its lifestyle, and then I get help from other things. That's what we're sharing in the context of this conversation. Amy was talking about, she does all the things, PRP, stem cell stuff. It's very interesting. There's a continuum. It's all very relative. To some people, Botox may be like taboo and then others are like, "I'll do everything up to surgery." Some people are like, "I want to do everything up to surgery and surgery," and there's no judgment provided that you can afford it and you're not body dysmorphic. I think that everyone has to decide what they're comfortable with and what makes sense. From my perspective, I just wanted to add that caveat that I think I want to be fully transparent as a 51-year-old female that I try to do as many things as I can to feel as good as I look internally and reflect that externally as well.

Melanie Avalon: Yeah, I could not agree more. And then when I was talking to that friend, I said, I was like, “Well, it's a neurotoxin.” He was like, “Well, wine is a neurotoxin.” I was like good point [laughs] or alcohol. Yeah, no, I agree with the perspective and what's important to you and no judgment and just do you.

Cynthia Thurlow: I think it's just a healthier space to exist, and I don't have the emotional bandwidth to sit around and be judgy of other people's choices. It's like as long as you're not hurting anyone, there's very few absolutes where I'm okay, that's not a good decision. If you're harming yourself, a child, an animal, other humans, that's not good. Beyond that, it's like, I just don't have the bandwidth to worry about what everyone else is doing. It's like, if it works for you, that's great. If it doesn't, then course correct. 

Melanie Avalon: Also, one last thing to that point and I mentioned this earlier, but it's like, oh, if you're getting Botox, people might think you're lying about the importance of safe skin care or antiaging skin care. But, if you think about it, they're all really important. Like doing a process where you're paralyzing the muscle and keeping wrinkles from forming from just the mechanics of your skin doesn't negate the super overwhelming importance of taking care of your skin. Like, you would still need to do both.

Cynthia Thurlow: I take AG1 several times a week after working out and when I’m ready to break my fast and it really makes me feel unstoppable. I love to add it to a protein smoothie or actually will drink it with filtered water and I love both variations. My 17-year-old also enjoys AG1 after a workout to ensure he stays really well hydrated. A great deal of what I focus on in my personal life is ongoing gut health improvement. I do feel fundamentally that AG1 has contributed significantly to improvements in my gut health over the last three years. I feel as if the key health benefits from multivitamins, minerals, pre and postbiotics all work together synergistically to improve my gut microbiome. AG1 is way more than just greens. It’s important to note that it’s made with 75 super high-quality vitamins, minerals, and whole food source ingredients that deliver incredible benefits to the gut microbiome, as well as sleep support, assistance with energy, and so much more.

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Melanie Avalon: Damon wanted to know, laser hair removal, is it worth it?

Cynthia Thurlow: Oh my God, yes. Oh my God, yes. It's funny. You do laser therapy and then you realize in your 40s into your early 50s, you don't have as much body hair. So, I'm like, what was I thinking. I went gangbusters in my 30s. Yes, yes, yes.

Melanie Avalon: I agree. I don't think I commented on barely any of the comments in the thread. But when I saw this one, all I did was I wrote yes, all caps.

Cynthia Thurlow: Yeah, well, think about it. People spend years doing bikini waxes and electrolysis.

Melanie Avalon: And think about forgetting to shave your underarms or your legs. You don't have to anymore.

Cynthia Thurlow: Yeah, although it's funny, I did my legs and my bikini area and I guess I took too well to it because I bought a package. They were like, literally “You've done so well. What else can we do? What else can we do for you?” For me, it was like life changing because I had done like, bikini waxes every month forever and eternity, and then all of a sudden I was like, this is great. 

Melanie Avalon: It's funny because when they try to sell you stuff and they're like, “This will be the best thing ever,” and you're like, “But really?” No, it really is. [laughs] 

Cynthia Thurlow: No, it's resounding. It is worth every penny, every single penny. 

Melanie Avalon: Yeah. I've done the Brazilian, the arms, the legs. Now I'm doing the upper lip. I think that's everything. [laughs] There's nothing left.

Cynthia Thurlow: I had blonde hair on my face. I've been just doing dermaplaning because to me and it's like, here's a fun topic for conversation. During the pandemic, when I could not get to get threaded or dermaplaning or anything, my anesthetician had recommended something called Tinkle, T-I-N-K-L-E. You can find it on Amazon. It's like really inexpensive and it's a little like razor for women, so you can get rid of fuzz on your face. Oh my God life changing. I literally was like, what was I spending all this money on threading for, for years [laughs] and then waxing before that. I was like, “Oh my God.” 

Melanie Avalon: Is it special or is it just a little razor? 

Cynthia Thurlow: Yeah, so it's for your face and it's not as strong as what a man would use. To me, it's like I can use it in between facials. And it's amazing, just amazing. For all those little weird hairs, if you like mind just tweeze them. I'm like, “Oh my God, this is amazing.” So highly recommend.

Melanie Avalon: They always have these at Marshalls and TJ Maxx. Maybe not that brand, but I use those or I used to. Oh no, I still do because I'm still doing the upper lip. Okay, here's back to non-skincare health, beauty-related things. What are your top three book recommendations besides your own?

Cynthia Thurlow: Okay, I've given this a lot of thought, I would say the books that are really in terms of health and wellness, I'm going to just leave it there because there're so many books. I would say the books that really shifted my perspective on a lot of different things, XX Brain by Dr. Lisa Mosconi, who I've been trying to interview for a year. She's like knee deep in research. She works at Cornell. That book helped me solidify why women-- and this is my opinion why women can benefit from hormone replacement therapy.

I would say the other book that I found really helpful, like in that space is Why Estrogen Matters by Dr. Avrum Bluming and Carol Tavris. I have had him on the podcast. We will link that in the show notes. The Women's Health Initiative is probably the most detrimental study that's ever been conducted on women in terms of the net impact on practitioners prescribing hormones and women taking hormones. You have a whole generation of clinicians and women who are fearful to take and/or prescribe medications. 

I would say, most recently, a book that really has had what I would say is this book, is the book I can read now because I've done the work. The Myth of Normal by Dr. Gabor Mate and that podcast will be out with him on December 24th. So, talking about the role of trauma in your life, I mean, he's changing the narrative for the way that we view trauma and doing it in a way that is through the lens of compassion and as someone that's a survivor of childhood trauma, both physical and emotional. For me, that book just allowed me to view my parents from a very compassionate lens. I would say those books right now in terms of health and wellness are the books that I probably recommend the most. For full disclosure, they're not easy-breezy reads. Lisa Mosconi's book, I think, is one that I recommend quite a bit to patients and clients that is more accessible. Myth of Normal is excellent, it's long and I would say that Why Estrogen Matters is a good read as well. How about you? 

Melanie Avalon: That's really awesome recommendations. So, I think my favorite is Lifespan. Oh, wait. No, I'm torn. Well, okay. So, Lifespan, David Sinclair's book, Why We Age and Why We Don't Have To. It's basically just everything I'm obsessed with. And what I love, when I interviewed him on the show, I might have told you this. Did you know he drew all of the characters in the back? 

Cynthia Thurlow: Really? So talented. 

Melanie Avalon: Yeah. He said that because in the very back there's hand drawn pictures of the people and everything. He drew all of those. He said he drew them because he wanted to put the actual pictures or whatever, but they couldn't get the rights to everything. So, he's like, “I'll just draw it.” [laughs] Isn't that crazy? 

Cynthia Thurlow: Well, that's along the lines of, like, when I'm in awe of people that are doing something artistic on a stage in the performing arts, okay, there's another level to my respect for him. 

Melanie Avalon: Yeah, no, it's insane. And if so you listen to my, that was the first interview I had with him. If you listen to it, he tells me this in real time, and I'm just, like, in shock, in shock. I'll probably say, this is so hard. You know what I haven't read The Paleo Solution since I read it in, like, 2012. But that's what changed my life. Like, that's the reason I'm doing what I'm doing today. Robb Wolf's book, I think I will have to include that I'm torn between James Nestor's Breath and I think I might have to do Kelly McGonigal's The Upside of Stress just because that book-- I need to try to get her on the show. That book was so valuable for me because I started stressing so much about stress, which, yes, stress has a lot of negative health effects. That's no surprise. It's not really negotiable. There's this whole aspect to it where perception affects how stress affects you. And so, reading that book took the biggest weight off of my shoulders about stress and how you can reframe your experience of stress and use it to your benefit rather than as a detriment. 

Cynthia Thurlow: I love that. It's someone said to me years ago, trying to pick your favorite book is like trying to pick your favorite child, it's impossible. Where I sit, where my desk is in my study, I literally have the ability to see hundreds of books. It's so hard because there're so many great books that I've read, but it's impossible to have a favorite. Just for listeners to understand, those are the three that have had the most impact on me. They've just completely blown my mind. Obviously, the ones that Melanie is identifying, two out of three I've already read. But I'm always reading. Just like, Melanie, I've actually got Sally Norton's new book on my floor to read, I'm like after I get done with podcast prep for this week. 

Melanie Avalon: I feel so bad because I always get her confused with Susan Owens because they both talk about oxalates a lot. I've had her on the show.

Cynthia Thurlow: Yeah, this will be my first time. I've had one other oxalate expert who I think is trained with her, but her book is coming out. So, I was like, it's probably time to revisit the oxalate issue. 

Melanie Avalon: That's awesome. I didn't realize she had a new book coming out. 

Cynthia Thurlow: Yeah, it's called Toxic Superfoods. [laughs] I'm sure there will be lots of overlap with Gundry's kind of methodologies about plant-based toxins.

Melanie Avalon: That's awesome. Awesome. Here's a quick one. This is from Danielle, "What is your favorite holiday tradition?"

Cynthia Thurlow: I think a lot of the traditions that are important for us is just a lot of togetherness, a lot of disconnection from work and social media and things like that. I would say there're a lot of things that we have done as a family including like decorating the tree, decorating the house, making cookies. When my kids were younger, they were more interested, invested in those things. But I think it's the quietness around, like Christmas Eve when we go to Mass and then we read particular Christmas books and then there's a nice meal and just savoring that time. There was a recent study that came out and it talked about how much time you spend with different people throughout your lifetime. As someone with a 17-year-old and 15-year-old, I read this study and my heart hurt. The great thing that I'm going to bring to this conversation is that it just reaffirms why it's so important to connect with one another. 

So, when I think about holidays, I just see it as connection, like spending time together, making meals together, making memories together, not per se, like one specific thing, like do we drive around and look at Christmas lights? Yes. Do we make specific kinds of meals? Yes. But what I value the most, especially now that my kids are older, is just being together, being silly, watching movies, trying to deal with all of the challenges of navigating in laws and parents and expectations for kids and everything else. How about you? Does your family have special traditions around Christmas or the holidays? 

Melanie Avalon: Well, first of all, I'm obsessed with everything Christmas, and mine was basically the same on Christmas Eve, we'd always had a tradition growing up of opening like, one present the night before and trying to make it a present that is something we could do together. Normally it's like if somebody gave somebody a game or something, and then we would do the gift and yeah, that's always been my favorite thing hands down. We are a big wine loving family. Having the Christmas wine and opening the presents and the Christmas Eve and playing the music, Trans-Siberian Orchestra, I am all about it. I love it. Actually, what we've started doing, I feel like it's been ever since everybody's been adults, it's been changing around. Now sometimes I think last year, maybe even the year before, we opened all of our presents just on Christmas Eve, the night before, because people are more, I don't know, spirited and lively in the evening than coming all over during the day.

Cynthia Thurlow: We've tried that. My kids always beg. My husband's kind of a traditionalist about the gift stuff. I think because I grew up with divorced parents, we just opened gifts. When we opened gifts, it wasn't regimented. My kids every year are like, can't we just open gifts on Christmas Eve. And my husband gets very rigid. I just always say, my husband's 90% of the time he's really easy going, and if he gets fixated one thing, I just tell the kids, back off. So, yeah, they're allowed to open one gift on Christmas Eve and then the rest on Christmas. 

Melanie Avalon: Yeah. We didn't start doing this until very recently, and we're all very much adults now, but growing up like your kids' age, we never did more than one the night before. I don't think we even wanted to. My dad is that way with Monopoly, because Monopoly is always the game we would always play, and we'd always want to do things like play how there's, like, 50 million spin offs of Monopoly, like, all the different themes? No, he, like, only wants to play the original. We would always have debates about, like, the rules and because there's a lot of, I think, like, little fun things you can add or change the rules little bit, nope. [laughs] It had to be the traditional way in the rule book. 

Cynthia Thurlow: I'm married to an engineer, so I'll just leave that there. Anyone that's married to engineers, know engineers, you understand they can be a little rigid sometimes, but I give him a lot of credit because he's usually pretty laid back about a lot of other things. 

Melanie Avalon: So funny. Two last quick ones. So, one is sort of health related. Leslie says, “I work at HOTWORX, 24 hours Infrared Fitness Studio. What do you think about a 3D workout heat exercise infrared sauna?” 

Cynthia Thurlow: Okay, I know exactly what HOTWORX is and I love the idea. I'm going to come at this from two lenses. So, number one, I hate being hot, really hot when I'm exercising. Hate it. Like warm yoga, good. Ashtanga yoga, that's at 105 degrees. No, don't enjoy it at all. For me personally that would be a no, because I just don't enjoy being really hot unless it's hot because I'm exercising at a level that I'm increasing my basal metabolic rate and my internal thermostat.

Number two, I think the concept of a 3D workout sounds great. I think it's probably highly bio individual. If you are a 25-year-old woman who is really lean and you're pushing yourself all the time, and you're not getting a menstrual cycle and you're overdoing it, I kind of call it the triad of over fasting, over exercising, over restricting. 

But I think for probably the average person, it's probably, like, a fun way to exercise. We have to think about what heat and exercise are. They're forms of hormesis. It's the right amount of stress at the right time. I think that it's important to recognize where are you in your cycle, how is your sleep, what's your stress like. Like, it's just adding additional stressors to your body. I think in the context of someone who's sleeping well, who's in the follicular phase of their menstrual cycle, who doesn't have too much stress, that's not overdoing it and is staying hydrated, it's probably fun. That would be my guess. 

Melanie Avalon: That was basically my answer, was that I think it could be really great like, it can be a great way of hacking and getting more bang for your buck as far as benefits go. But you also need to know yourself. I'm literally just spitting out what you just said. You have to know yourself and some people it's going to be too much and it's going to be overdoing it and it's not going to have the beneficial effects in the long term because it's not allowing the adequate recovery in between. And if it's fitting into an overly stressful lifestyle anyway, it might not be the way to go. I think you really just have to know yourself. I haven't done HOTWORKX. 

Cynthia Thurlow: Yeah. no offense to anyone who loves working out in a super hot environment. I hate it. I've been that way my whole life. Hate it with a capital H. For me, like if I went to the gym and it was cold in the gym, good. If I walk outside and it's kind of hot and humid, not as interested in walking as long. But it's not that I don't see the utility I just personally hate being that hot. I hate it, just despise it. The only thing I can compare it to is like, being in Morocco, which was like an oven. [laughs] We're telling my husband I don't think we'll ever come back because it was just so hot. 

Melanie Avalon: I'm the same besides my sauna sessions where the purpose is being hot and it's relaxing, especially with infrared, not getting that hot. But I'm not about the heat. I'm all about the cold. are you guys getting a crazy cold front because it's getting down next week to 10 degrees. It doesn't get 10 degrees here. 

Cynthia Thurlow: Yeah. Atlanta is going to be in a kerfuffle. Yeah. For me, it's like when I walked my dogs this morning, it was 30 degrees and it's like perfect for them. I put a hat on, I've got a light jacket on and I'm totally happy. 

Melanie Avalon: I'm so pumped. Especially because the last few years has been warm on Christmas, it's going to be like 15 degrees. I am all about it. This is going to be great. 

Cynthia Thurlow: Yeah. I just feel like Christmas should be cold. We had, gosh it was probably ten years ago, we got snow in Virginia on Christmas Eve and it was like a dusting, but that's still like in Northern Virginia that's a shutdown mode. Everyone's freaking out. I was like, this is completely appropriate.

Melanie Avalon: I'm just worried about ever since that Texas, was it Austin or wherever when it got really cold and didn't it mess up all of the water, like the pipes and everything. I'm like, please, that cannot happen. [laughs] I need my toilet.

Cynthia Thurlow: Well, you know what they always say. I lived in a neighborhood in Northern Virginia and most of the homes were new construction when people bought them and the builder knucklehead that they were a lot of exterior pipes were freezing during really cold spells. If you're ever concerned about your water freezing in a pipe. You can always keep your water like a little drip just to kind of keep things moving. Yeah, lots of experience with friends who went through that. Not fun. Not fun at all. 

Melanie Avalon: Yeah, they always post-- when it starts getting cold they post signs everywhere saying, “Freeze warning and let your faucets drip.” Okay, well, this was fun. This is definitely going to be a two-parter. I'm thinking it's probably going to be a three-parter, maybe a four-parter. 

In any case, for listeners, if they would like to submit their own questions for the show and if this is your first episode listening, which since we get so many listeners, it probably is somebody's first episode listening, welcome to that person. Normally we talk about Intermittent Fasting a little bit more. You can submit your own questions to questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. These show notes will be @ifpodcast.com/episode300. Those show notes will have a full transcript as well as links to everything that we talked about. So, definitely check that out and you can follow us on Instagram. We are @ifpodcast. I am @melanieavalon. Cynthia is @cynthia_thurlow_. I think that is all the things. Well, this is been really, really fun, Cynthia. Anything from you, before we go?

Cynthia Thurlow: No, I'm looking forward to round number two.

Melanie Avalon: All right, sounds good. I will talk to you next week. 

Cynthia Thurlow: Sounds good. 

Melanie Avalon: Bye. 

Thank you so much for listening to the Intermittent Fasting Podcast. Please remember everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week. 

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Jan 01

Episode 298: Clean Hair Products, Skipping Meals & Mortality, Dietary Recall Studies, Defining OMAD, Breaking Fast Easily, Satiety, And More!

Intermittent Fasting

Welcome to Episode 298 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

BUTCHERBOX: Grass-Fed Beef, Organic Chicken, Heritage Pork, Wild-Caught Seafood: Nutrient-Rich, Raised Sustainably The Way Nature Intended, And Shipped Straight To Your Door! For A Limited Time Go To butcherbox.com/ifpodcast And Get The New Year Bundle For Free Plus $10 Off When You Sign Up Today. That’s A 14 Oz Pork Tenderloin, 2 Lbs Of Ground Turkey, And 4 Top Sirloin Steaks Free In Your First Box!

ATHLETIC GREENS: 75 High-Quality Vitamins, Minerals, Whole-Food Sourced Ingredients, Probiotics, And Adaptogens In One Delicious Scoop! Get A FREE 1 Year Supply Of Immune-Supporting Vitamin D AND 5 FREE Travel Packs With Your First Purchase At athleticgreens.com/ifpodcast.

 JOOVV: Like intermittent fasting, red light therapy can benefit the body on so many levels! It literally works on the mitochondrial level to help your cells generate more energy! Red light can help you burn fat (including targeted fat burning and stubborn fat!), contour your body, reduce fine lines and wrinkles, produce collagen for epic skin, support muscle recovery, reduce joint pain and inflammation, combat fatigue, help you sleep better, improve mood, and so much more!! These devices are literally LIFE CHANGING!! For A Limited Time Go To Joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount!

To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get The New Year Bundle For Free Plus $10 Off When You Sign Up Today. That’s A 14 Oz Pork Tenderloin, 2 Lbs Of Ground Turkey, And 4 Top Sirloin Steaks Free In Your First Box!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

The Melanie Avalon Biohacking Podcast Episode #110 - Jon Levy

Ep. 160 – The Power Of Behavior-Centric Health & Wellness: Trade-Offs for a Long and Happy Life with Jon Levy

ATHLETIC GREENS: Get A FREE 1 Year Supply Of Immune-Supporting Vitamin D AND 5 FREE Travel Packs With Your First Purchase At athleticgreens.com/ifpodcast.

Listener Feedback: Diane - Better hair products

KNOW YOUR ENVIRONMENT. PROTECT YOUR HEALTH. EWG.

Episode 294: Creatine, Excess Skin, Toning Up, Clean Hair Dye, Hormones, Caffeine, Cortisol, Hormetic Stress, Jet Lag, Hydration, Melatonin, And More!

Listener Q&A: Cara - New study found increase risk of early mortality with fasting?

Meal Skipping and Shorter Meal Intervals Are Associated with Increased Risk of All-Cause and Cardiovascular Disease Mortality among US Adults

JOOVV: For A Limited Time Go To joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount!

Listener Q&A: Kemla - Does it matter?

Episode 116: The Great OMAD Debate

Listener Q&A: Nancy - one meal a day?

Listener Q&A: Spencer - Breaking fast

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 298 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting and Wine. I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time and get ready for The Intermittent Fasting Podcast.

Hi friends, I'm about to tell you how you can get a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, plus $10 off. Yes, all of that incredible meat, plus $10 off, all for free. We are a bit obsessed with a company called ButcherBox, which is always in season. Some of my favorite meals that I had throughout the holiday season were fantastic meat and seafood from ButcherBox. Now with the new year, it is time to celebrate with only the very best of the best when it comes to meat and seafood that you put in your body, as well as meat and seafood that helps support our planet and the environment.

They make it so, so easy to get high-quality humanely raised meat that you can trust. They deliver 100% grass-fed, grass-finished beef, free-range organic chicken, heritage-breed pork that’s really hard to find, by the way, and wild-caught sustainable and responsible seafood shipped directly to your door. When you become a member, you’re joining a community focused on doing what’s better for everyone. That includes caring about the lives of animals, the livelihoods of farmers, treating our planet with respect, and enjoying deliciously better meals together. I did so much research on ButcherBox, you can actually check out my blog post all about it at melanieavalon.com/butcherbox.

All of their beef is 100% grass-fed and grass-finished and they work personally with all the farmers to truly support the regenerative agriculture system. I also did an interview with Robb Wolf on my show, The Melanie Avalon Biohacking Podcast, all about the massive importance of supporting regenerative agriculture for the sustainability of not only ourselves but the planet. This is so important to me. I’ll put a link to that in the show notes. The value is incredible. The average cost is actually less than $6 per meal and it's so easy. Everything ships directly to your door and it is so delicious. I love carpaccio for example. The ButcherBox steaks are incredible for that. That's how you know it's good steak when you can eat it rare like that and ButcherBox has an incredible offer for our audience.

You can get the New Year bundle for free, plus $10 off when you sign up today. That's a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, in your first box. Sign up @butcherbox.com/ifpodcast and use code IFPODCAST to claim this offer. Again, to get a 14-ounce heritage-breed pork tenderloin, 2 pounds of sustainably raised ground turkey, and four grass-fed top sirloin steaks, all for free, plus $10 off, sign up @butcherbox.com/ifpodcast and use code IFPODCAST to claim this offer. We'll put all this information in the show notes.

One more thing before we jump in, are you fasting clean inside and out? So, when it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting. It's actually our skincare and makeup. So, as it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disruptors, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. 

And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies, when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking. And the effects last for years. 

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies and so much more. 

You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my Clean Beauty email list. That’s at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list, so definitely check it out. You can join me in my Facebook group Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you’re thinking of making Clean Beauty and Safe Skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It’s sort of like Amazon Prime for Clean Beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. And we’ll put all this information in the show notes. All right, now back to the show.

Hi everybody and welcome. This is Episode number 298 of The Intermittent Fasting Podcast. I’m Melanie Avalon and I’m here with Cynthia Thurlow.

Cynthia Thurlow: Hi, Melanie.

Melanie Avalon: Hi, Cynthia. Can I tell you a story and also ask you a question? They're unrelated.

Cynthia Thurlow: Of course.

Melanie Avalon: Okay, great. [chuckles] This week I had a really crazy moment. I had two interviews for press-related stuff, and I was prepping for one of the interviews. You might have seen this on my story, so I'm sorry if I'm telling the story again. I was prepping for one of the interviews and I knew one of the questions was going to be about being a female entrepreneur. So, I googled, well in DuckDuckGo but it happened in Google too. I checked. In DuckDuckGo, I googled “tips female entrepreneur” the first hit, literally the first hit was an article from Forbes, and it was the one I was in. And not only was it the first hit, but the preview text was my part of the article. So, I literally googled something to prep for the next day and I was the first hit. Isn't that crazy. I keep thinking about that. That's very surreal. Like, out of all the people in the world. 

Cynthia Thurlow: Yeah, that's amazing. 

Melanie Avalon: So, I thought it was funny that I was trying to find the answer and I clearly already had the answer. Yeah, that was my fun story. And then I have a question, but do you have any fun stories you would like to share? I know you saw Hamilton.

Cynthia Thurlow: I did. We were in New York City this past weekend, so my family and I, it's the first time we've all been together in New York in five years, which is hard to believe and it's very different with preteens versus teenagers. We had a lot of fun and Hamilton was worth every effort at seeing it on Broadway. I'm just phenomenal. The irony is I flew back to New York two days later for the Influencers Dinner. 

Melanie Avalon: All right, with John. 

Cynthia Thurlow: Yeah. Which I did last night, which was amazing. I met such amazing human beings and people that were in different fields. The irony is the only person who guessed.

Melanie Avalon: Who all were there? 

Cynthia Thurlow: There were artists, there were chief marketing officers for major brands, like recognizable brands. There was a cardiologist who was in the midst of the pandemic, like, hitting New York City, who was absolutely brilliant. People just in different fields, but all really interesting like, there was a guy who had been a record producer for, like, Biggie and Pink, just such a diverse group of people, but no egos. Everyone was lovely and you were not allowed to give your last name or what you did. So, we were all interacting and then went about putting a meal together and then sat and had a meal. We went around the table trying to guess what everyone did. 

The person who guessed correctly, what I did turned out to be the cardiologist, even though we had not even talked about any of these things. He was just such a cool person. I would never have guessed he was a cardiologist because of his personality. He was just kind of more free spirited and relaxed and not nearly as intense as most of the other people. I had an amazing evening, but I was up really late for me and then was up at 04:00 in the morning and I'm working on a solid, like, 4 hours of sleep. So, I'm sure tonight I will crash. But right now, I'm running on adrenal and it was an incredible experience. I told John that you said, “Hello.” 

Melanie Avalon: That makes me so happy. I love hearing about those events. I really want to go to one as well. John keeps sending me all the dates. I'm like, “I'm going to come to one, I promise.” 

Cynthia Thurlow: Yes, it was a lot of fun. I guess the thing that was really interesting was one of the we thought was participants turned out to be his mom, who was so lovely. I got to meet her and she was visiting from Israel. It's interesting when you see people in their natural habitat because this was actually a dinner at John's house. He was totally gracious and very supportive. I went home with a signed copy of his most recent book. His dad was this incredible artist and went home with a book of his father. So, it was like, all in all, just a really incredible, like less than 24-hour experience. Yeah, no more New York travel for a while. 

Melanie Avalon: That is amazing. John and I have been bouncing off ideas. I don't know if we're going to do this. We've been thinking we should start a podcast or something just because we talk about all of these crazy, random topics. He's so well connected. I just feel like there's a lot that we could do. [chuckles] So that's so exciting. Wow. Yay.

Cynthia Thurlow: Yeah. It was a really great experience. 

Melanie Avalon: Well, for listeners, we'll put links in the show notes. Cynthia and I both had John on our shows, so we will put links to the episodes that we had with him. His book you're invited is super cool. It's all about how well, I think the subtitle is something about the art of cultivating influence. But it's about how people cultivate influence. It's about how people become, like, respected leaders with communities and basically leaders of groups and things like that. It's really interesting. It's human psychology. So why people do what they do. So, yeah. 

Cynthia Thurlow: What was really interesting was that only a few people in the room knew who he was, but they still came to this dinner, which I thought was so cool because someone said to me, like, “How do John?” I said, “Oh, well, through my friend Melanie, but I've also had him on my podcast.” He made sure that he was like, if you ever need any support in your business or you have questions, I'm here for you. I think it's a really phenomenal way to network with people because you're so disarmed, because you're not allowed to lean into what's easy, meaning, like talking about your work or leading with your title, whatever it is that however people lead. That's not the way that I am. When you're making a meal with people, you really just get very relaxed, invested in the process. And so, we even helped clean up. We even did dishes. Everyone was part of making the meal, cleaning up for the meal. It was a really delightful evening. 

Melanie Avalon: That's so fun. It's nice for him, too, not to have to do dishes at the end [chuckles] of all these dinners because he has a lot of them and he does them in LA, San Francisco, and New York. 

Cynthia Thurlow: Well and I think it's just nice to feel like this is really the first time I've been in New York. Maybe in September when I was there, when I spoke, but this is the first time I've been back in New York where it's felt like the New York I remember. There's still a lot of mask-wearing, that's a whole tangential conversation and there's no judgment. I'm just saying observationally. There was a lot of mask-wearing and people just being conscientious, but people just seemed, like, happy to be back interacting in person in real life with other humans. 

Melanie Avalon: Yeah, that's awesome. I should probably say his last name is John Levy. I don't think I said that. 

Cynthia Thurlow: He's so smart. He was even talking about his siblings, all of whom are incredibly accomplished, too. When we found out his mom was at the table, I was like, “Oh my gosh, this is so amazing.” 

Melanie Avalon: That's so cool. Yeah, I love that. My question for you, because this episode airs January 2nd, so this will be the day after New Year's Eve or the day after New Year's Day. Cynthia, do you make New Year's resolutions and do you recommend that people do?

Cynthia Thurlow: I think that I personally don't per se change a lot from year to year. I'm of course open to the possibility, but I try to have a word of the year. That's what I lean into. In some years balance or dedication or whatever I'm leaning into and so, I'm mulling over the idea of what is going to be my focus for 2023. On a lot of different levels, I think it's probably going to be clarity about where I am in my business and where I am in my personal life. So, I do think it's a good idea to evaluate behaviors, what works, what doesn't work. But to me, I don't like to think of it as like a New Year's resolution because that to me, really means a temporary thing, whereas if I have a focus for the year, that's how I choose to frame it so that it's something I'm going to be consistently working on month to month, day to day. And so, clarity is my 2023 word, I'm fairly certain. How about you?

Melanie Avalon: That is super cool. I like that. That's a very practical, implementable thing that people could do. Maybe I should do that. I don't really and I think it's because I kind of feel like every day is like a New Year's resolution day. Like constantly, I’ve so many dreams and goals, and I always feel very inspired and motivated to be doing them. So, it doesn't feel like, “Oh, this is the chance to start anew.” I'm constantly in that vibe. Not to say that people who make.

Cynthia Thurlow: Growth headspace.

Melanie Avalon: Yeah, but I don't mean by that people who make New Year's resolutions aren't that way. It's just it doesn't feel like a milestone in my personal life right now. It might change. I'd be really curious though, if people want to tell us their New Year's resolutions. I wonder if the most common New Year's resolutions like what they are. Like the top 10. I would bet one of them is weight loss, but I bet one's probably career related.

Cynthia Thurlow: So, I am fully adulting now and between our financial advisor, our financial planner, my CPA in my business, it's like we've gotten very granular. I think part of the clarity piece for me, just for full transparency, is that we've gotten really, really, really specific in my business about where my energies go, where they do not. I'll give you an example as I'm sure it happens to you. You get asked a lot to do press, you get asked a lot to do guest podcasts. I was finding that I was spending so much time supporting other people's podcasts that I wasn't creating the space for me to be able to be in my business and not be stressed going from one thing to another. One of the rules that I created with my team was that I only do two guest podcasts a month and I could easily do 20.

It's one of those things where we've gotten very specific about what metrics, what's their audience like, is it a good fit. That's made me very happy because coming off of the book launch, this year has been wonderful but exhausting and it's not a pace I want to keep up. This is not to suggest my podcast is going anywhere or this podcast is going anywhere. I'm just talking about guest podcasting and is it in my best interest to be overcommitting myself. So, as an example, we've already filled the two spots in December, we filled the two in January, now we're working on February. That has allowed me to feel like I have a little bit more breathing space and so we're doing things like that because that serves my higher purpose. Then I can devote more time to my business and not feel super stressed, which has been my baseline this whole year for sure. 

Melanie Avalon: Yeah, no. I think that's amazing and that's something I've been really working on as well, is you want to just say yes to everything, but you can't. You need to know [chuckles] when to say no and that's okay. 

Cynthia Thurlow: Yeah, well, and it's interesting, when you really start getting granular about metrics and who is their audience, is it really serving my best interest and their own to have me on. We've had to politely say no to a lot of opportunities because I either don't want to be traveling all the time, that's another thing. Getting very clear about what speaking events I'm going to do and what are the things that are going to lead to more opportunities and understanding that, you and I both know this that our time is valuable as is everyone's. but does it serve me to be on planes and flying all over if it's really not laser focused on what I'm working towards. That's the one thing I would say, “Clarity.”

Melanie Avalon: Yeah, I think that's great. 

Cynthia Thurlow: I take AG1 several times a week after working out and when I'm ready to break my fast and it really makes me feel unstoppable. I love to add it to a protein smoothie, or actually we'll drink it with filtered water and I love both variations. My 17-year-old also enjoys AG1 after a workout to ensure he stays really well hydrated. A great deal of what I focus on in my personal life is ongoing gut health improvement. I do feel fundamentally that AG1 has contributed significantly to improvements in my gut health over the last three years. I feel as if the key health benefits from multivitamins, minerals, pre and postbiotics all work together synergistically to improve my gut microbiome. AG1 is way more than just greens. It's important to note that it's made with 75 super high-quality vitamins, minerals, and whole food source ingredients that deliver incredible benefits to the gut microbiome, as well as sleep support, assistance with energy, and so much more.

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Melanie Avalon: All ready. Shall we jump into everything for today? 

Cynthia Thurlow: Absolutely. 

Melanie Avalon: So, to start things off, this is actually some feedback from a listener. We recently were discussing toxic hair products and whether or not there were options for coloring your hair and we provided some brands. We just got some quick feedback from Diane, and the subject is “Better Hair Products.” And she says, “Hi there, just wanted to remind folks about the EWG website. Listening to your last podcast, someone asked about less toxic hair color/care. I've been looking for a while, and I found a few cheaper brands of hair shampoos and conditioners as I like to switch them often. Herbal Essence has some that rated low. Obviously, the scented ones rate a bit higher. Unscented castile soap is a one." I'm just going to insert something. This is Melanie talking. I am obsessed with unscented castile soap. I use it for everything. Do you use it, Cynthia? 

Cynthia Thurlow: I do. 

Melanie Avalon: I use it in the shower to take my makeup off and the sink to wash my hands. I mean, that stuff is just amazing. 

Cynthia Thurlow: And it lasts a while. 

Melanie Avalon: Yeah, it does. Yeah, it's incredible. I think you can also use it for the dishwasher and clothes if you make certain concoctions, but I haven't done that. She says, “I'm sure there are more, but I can't get into my personal list on the EWG website, I also found a pump hairspray that smells edible. It's raspberry and reminds me of one from the 80s that I used to use, but this is much friendlier and far less toxic. It's made by All-Nutrient, which is local to me, but I see they sell it on Amazon. I also tried a brand called I think it's Qet and the sample they sent, but it was the size of a paperclip and despite my toddler-sized hands, I couldn't even spray the thing. As far as color and lighting, I'm with you. I asked my three hairdresser friends to research this and find the least toxic/gentlest kinds, but no luck yet. Love listening to and learning from you and Cynthia XOXOX.”

I'll just comment if listeners check out that other episode. We did list quite a few dye brands that were options and I would actually love if people do have experience with nontoxic hair dye. I would love to hear if people have found brands that they like, because it's definitely one of the areas where there doesn't seem to be a lot of options. I'm surprised we didn't mention the EWG. Definitely, the EWG is amazing. 

Cynthia Thurlow: Yeah, their Skin Deep app is certainly very helpful. Diane, thank you so much for sharing those. It gives us more options to consider. Listeners, if there are other brands that you like using that are cleaner, certainly pass them along. I think to me it is a work in progress. Hair is my pain point. I'm very transparent about that, but that does not mean that there aren't wonderful options that are out there. I'm just happy I'm using Argan oil, which is super helpful for the frizz that I experience about eight months out of the year, here in very humid hot Virginia. 

Melanie Avalon: Yeah, I'm having flashbacks to growing up in Memphis and the hair situation. 

Cynthia Thurlow: I didn't realize you grew up in Memphis. I thought you grew up in Atlanta. 

Melanie Avalon: Yeah, well, I was here until 10. I was in Memphis my formative years of 10 until 17. So, middle school and high school, elementary school part of it. What's interesting is out of the entire timeline of my life, I've lived in Memphis the least. Compared to Atlanta and Los Angeles, Memphis feels like where I've lived the longest because it was when I was growing up. 

Cynthia Thurlow: So cool. Little known facts. 

Melanie Avalon: I know. Shall we go on to our next question? 

Cynthia Thurlow: Sure. This is a question from Kara and it says, “New study found to increase risk of early mortality with fasting. Please interpret.” "Hi, I saw this post on Instagram from @fastingmd. The study is referenced in the show notes. She mentions, “I love this way of life. I typically fast while I'm seeing patients because I know my brain is more clear and I am more focused. It's usually about 18 hours. I've recently tried a snack at 2:30 to take probiotics for leaky gut, but I just don't like the way I feel less on if I do have a snack. After months of trying to figure out my gut issues, I went to a functional medicine practitioner based on your advice. It was the best thing I've ever done. I had no idea how not normal my bathroom experiences were, but also the amount of mental exhaustion from worrying and trying to figure out what it was that I ate that caused the issues. I tried eliminating every food category with very little improvement. To the listeners out there who this is ringing true for, go get a specialist to guide you. I am a healthcare practitioner and I couldn't solve it on my own. I'd love to hear your opinions about the study, Kara. 

Melanie Avalon: Awesome. Well, Kara, thank you so much for your question and your experience. I will just comment with the probiotic snack thing. I don't know which probiotic you're taking, but a lot of probiotics you could take it with your meal or possibly even on an empty stomach. I would just look at your probiotic again and see if it indicates that it needs to be taken with food. But I feel like most probiotics you could take on an empty stomach, so that might be an option. Also, thank you for sharing your experience and your openness about being a healthcare practitioner and realizing that you can still benefit from a third-party perspective guiding you. That's super amazing. The study that she referenced is called Meal Skipping and Shorter Meal Intervals Are Associated with Increased Risk of All-Cause and Cardiovascular Disease Mortality among US Adults. It was published August 10, 2022 in the Journal of the Academy of Nutrition and Dietetics. 

It was a prospective study. It looked, in retrospect, at a lot of people, a total of 24,011 adults who had participated in surveys about food intake and eating behavior using 24-hour recall from 1999 to 2014. What it did was it looked at a lot of things, but one of the main things that looked at and why everybody is talking about this is it looked at the role of meal frequency and how it related to cardiovascular disease and mortality and they separated it into different options. There were people that skipped breakfast, people that skipped lunch and people that skipped dinner. They found that people who skipped breakfast had a higher cause for CBD mortality compared to those who didn't. People who skipped lunch and people who skipped dinner had a higher cause for all-cause mortality.

So, of course, it has a really scary headline, which is annoying and we can break this down. I mean, the headline makes it look like it is literally the meal skipping and the shorter meal intervals, because they also looked at how often people were eating, and they looked at that association. In the title, of course, they say that is leading to an increased risk of these diseases and death. But what did it actually find. So, what's interesting is it was looking at a lot of characteristics of people. So, it wasn't just the meal intake. The people who did not eat three meals per day, because the majority of the people so over half of the people were eating three meals per day. The people who weren't, so their general characteristics, they were more likely-- so it's a list. They're more likely to be younger men, non-Hispanic black, less education, lower family income, smokers, heavy alcohol drinkers, higher physical activity, lower total energy intake, lower diet quality, food insecure, and they snacked more. So, what's really interesting about this is [laughs] basically there was a lot of confounding factors happening in these people who were skipping meals. It's really really hard to say that it was the meal skipping that was the cause of this, when there were so many other things going on, unhealthy related habits that seemed to associate with it. 

Also, of interest of note, and I would actually be really curious, I would be super curious if this got redone now, if it would be different, because this occurred, like I said, from 1999 to 2014. Intermittent fasting has, I feel like, really become more popular probably in the last decade. Kind of near the end of the study is when intermittent fasting started becoming more popular. During the time of the study was definitely the time when we were all told that breakfast is the most healthy meal of the day. A lot of people who are skipping breakfast, especially during this time, might have had other unhealthy habits or on the flipside, people who are eating breakfast might more likely have had healthy habits. It's hard to associate causation from correlation is my point.

So, yes, the takeaway is that this was not cause and effect. This did not look at people's blood sugar levels. It did not look at an individual fasting and see what was happening in their body. It literally just looked at thousands of people what are they doing, how are they eating, and then what was their cardiovascular risk and their mortality risk. 

One last note about it, dietary recall studies can be a little bit problematic. I even heard Peter Attia say on an episode that he doesn't even ever consider dietary recall studies because we're just so bad with recalling. So, for example, in this study, from the original group of people, they removed 3136 participants due to implausible total energy intake. Meaning what those people reported didn't make sense realistically. There was really probably no way they were actually eating that. If there were 3136 people that were clearly overwhelmingly wrong in what they were saying, it makes you curious about the people that were included. So, yes, takeaways, dietary recall study issues, the timing of when this occurred during a time when fasting was not seen as a healthy practice, and then the confounding factors, I think, is huge and then lack of actual cause, and effect causation versus correlation. 

Not to say that there's not valuable information here, but those are my thoughts on this study. Cynthia, what are your thoughts? 

Cynthia Thurlow: I agree with everything that you've said. I think this is the challenge with nutritional research on a lot of levels. Patients oftentimes do not want to fully disclose what they're eating. It's not to suggest that's per se not kind of human nature, but more often than not, I know when I ask for diet recalls, sometimes I fervently believe that people tell me what they think I want to see or want to hear. Nutritional research in and of itself is challenging.

Number two, I do think that there are many issues with looking at research over a long period of time. As you very appropriately mentioned, we didn't know the insulin sensitivity of these individuals. It's my understanding from the study that it was a fairly unhealthy population that they were looking at and so, does it mean that there's more research that can be done? Absolutely.

As you appropriately stated, correlation does not mean causation and so that's why it's important. Really this is one of the challenges I have with the media is that they don't know how to properly interpret research and what they do is they like sensationalization and so, they'll throw out these articles. There's one in the New York Post that I got tagged in all over social media and people were saying, “Oh well, this is going to hasten your morbidity and mortality.” And I was like, "Hey, time out. Let's look at who sponsored the study, let's look at the data, let's look at the high quality of research.” 

We know that randomized controlled trials are the gold standard and obviously that's not what we're looking at here in this instance. I think it just really speaks to the fact we need more information, we need more research to look at this, but epidemiologic research in general looking at different types of research, nutritional research can be particularly challenging on a lot of different levels. I think it just remains to be seen. If we're looking at an already unhealthy population, it's very hard to extrapolate and then say this is applicable to everyone. Hopefully that's clear.

Melanie Avalon: Yeah. For example, what I would love for them to have done, which they could have done, I don't know, it's a little bit annoying. They could have separated it out because I mentioned all of those factors about people who were not eating three meals per day what they were more likely to be. I would be super curious if they separated out the people who were skipping a meal by any one of those confounding factors to see if there's a difference. Maybe since its food related, they could have done it by the food stuff. They could have split it by lower diet quality and food insecurity and seen if you separate it that way, do you still see that pattern. You could filter the data a lot of different ways and I bet you would have seen a lot of different things. So, it is what it is. 

Cynthia Thurlow: It's just the beginning point to really look at things. The other piece is that probably our listeners and ourselves, we don't eat a Standard American Diet and we recognize now how inflammatory and problematic the Standard American Diet is because it's highly processed, hyper palatable, too many carbohydrates, too many wrong types of fats, too little protein, and that doesn't help metabolic health at all. There're so many different things that usually when I'm looking at these kinds of articles, I always want to know like, what were they eating because I think that has a large impact on the results that they are reporting. 

Melanie Avalon: Yeah, it was interesting. I was actually thinking about that when I was reading the article because for diet quality, they actually broke down how they determined that, but they didn't give specifics. It was basically like-- It was like a dozen categories of components of food like fruits, vegetables, fatty acids. It was like a dozen of them, salt, sodium. Even within that, there's so much debate about diet. So, I find it interesting that even ranking things by diet quality, I mean, there would be nuance and debate within that. One other little note I did want to point out, I looked at the original post that she referenced on Instagram. I thought this was interesting. Do you know the @fastingmd, she follows you? 

Cynthia Thurlow: I do. I do. I think she's a fan of circadian fasting. That's kind of her cornerstone. 

Melanie Avalon: Okay, okay, got you. So, I don't know if she did this on purpose. I'll just assume she did not. It was a good moment that I thought was a good thing to draw attention to because this goes back to like really encouraging listeners to look at the source material, especially with things like this, where it gets into social media and the news. This is a very small thing, but I still think it's telling of what is happening all the time. So, for example, she mentioned what I mentioned about how the participants who are skipping meals were more likely to be all of these other factors which are mostly unfavorable in that they are associated with lesser health outcomes.

She listed the entire list, but she left out one which was the positive one. She left out higher physical activity and so it could have been an accident. I'm not saying it was on purpose, but I think it's a really good example, because I read it and I was like, wait, but higher physical activity was also one of the things on there. I think it's a good example of even when somebody says, even me right now saying, “What's in the study,” go read the original study. Because I think every time you hear not from the actual source material, you're getting a filtered biased version of it from me, from everybody, even from you. When you read it, you're going to give it your own filter and bias. The most unbiased version you can get is probably reading the original one. 

Cynthia Thurlow: I think that's important. I mean, we're realistic, I may not be able to read every single piece of research that's out there, but certainly the ones that are intriguing and really relevant. Looking at the sample size, I mean, just looking at basic tenets of the research that was done, I think can be very helpful. I have to believe if @fastingmd is anything like my team, sometimes they're so quick to get content up but sometimes things get missed. So maybe that was unintentional. But I know that Amy's, it's Amy Shah. I know that her content tends to be surrounded around honoring circadian biology as it relates to fasting. 

Melanie Avalon: Awesome. Yeah. Again, it probably was unintentional, but it was completely separate from her. It was a moment where I realized again how important it is to go look at the original stuff if you have the time and energy and it's something that you are interested in. 

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Shall we go on to our next question? 

Cynthia Thurlow: Sure. 

Melanie Avalon: We have two questions that are sort of related, so I thought we could answer both of them. So, the first one comes from Kimla. The subject is “One meal a day: Does it matter.” And Kimla says, "I hear a lot of disagreement about what really defines one meal a day." Cynthia, I'm just laughing because I think I mentioned before you know we've had, like, the great one meal a day debate on this show, like Gin and I have debated the definition of one meal a day at length, it became a whole thing. What really defines one meal a day? [chuckles] I wonder why so many people debate this. Is it just a label that people want to place on their fasting pattern?

According to Gin, I adhere to one meal a day, but if I use Melanie's definition, then it would only be sometimes. What I do know is that I typically fast for 21 hours. My eating window varies daily based on how hungry I am. Sometimes I have a five-hour window and sometimes two hours. I do use an app called LIFE on Android to track my fasting time since I've only been doing IF since June, and I always forget what time I quit eating the night before. I think I've gotten offtrack of what my question was now, basically, does it really matter if you truly eat one meal a day or is the fasting window the focus? When I start reading a lot about one meal a day or listening to all the debates over one meal a day and by the way, she's calling it OMAD. 

She says, “I start to get a little obsessed about how much I should or should not be eating during my window, and if I can have a snack or need to cluster all my food. I have noticed this tendency. So, instead I really just tried to pay attention only to how I'm feeling. This has been working great so far. I eat ice cream most nights after dinner which makes me so happy. IF is a keeper in my book. Thank you for all the information. The podcasts and resources have been great tools and I love this way of life. I have never lost weight so effortlessly, no special foods, no containers. I don't have to pack and drag food all over with me, I never feel hungry, and my crazy sugar cravings have disappeared. Thank you for clarifying this concept.”

We have another question from Nancy. The subject is “One meal a day?” and Nancy says, “I'm a new IFer and I've been doing a 16:8 fast. I read here a lot about having one meal a day during that eight-hour feeding window, which seems to contradict other things. I read or hear about eating all of one's calories within that eight-hour feeding window. I basically don't understand what it means to eat one meal within that eight-hour window. Does it mean that you can eat one meal, say at 12:30 PM, a big lunch or 07:30 PM, a big dinner and snack for the rest of your feeding window? If you do only one meal, what is the benefit of that versus spreading out your eating window within your eight-hour window? I like to have a lunch at 12:30 and a dinner at about 7:30. Is there a reason I shouldn't do that? Thanks.”

Before you jump in, Cynthia. I'll give you some recap of Gin and I's thoughts on this and what the great debate was, which in the show notes. The show notes will be at ifppodcast.com/episode298. We will put a link to the great debate, the great one meal a day debate episode that I have with Gin. It's ironic or it's interesting because Gin and I typically eat over the same amount of hours-ish, so it's typically like probably an average of a five-hour eating window, probably four to six hours. The difference is that Gin has a pattern where she has a snack and then she doesn't eat and then she eats her meal later, whereas I eat the entire time straight through [laughs] like the entire four or five hours. It's a very long drawn out pattern. Listeners probably already have it memorized. Like I eat my cucumbers and I drink my wine and then I'm cooking my food and then I eat my food, which is like my scallops, my protein, and then I eat a lot of fruit for quite a while.

Our big debate was I was saying for Gin, I was like, “Yours is like one meal a day and a snack because you're having a snack and then you're not eating and then you're eating.” I was like saying for mine that, “It's one meal because it's like being at a really long dinner where I'm constantly eating.”

Kimla's question about why does it matter, I really don't think it does. [laughs] It's more just the semantics of it. Although, that said for Nancy, I don't really know anybody who would consider like an eight-hour eating window at one meal a day. That's pretty long. So, I can share more thoughts. But Cynthia, what are your thoughts on the semantics of one meal a day? Does it matter? What do you call it? All the things. 

Cynthia Thurlow: Oh, goodness, I feel like I'm stepping into a landmine. So, Kimla and Nancy, thank you for your questions. First and foremost, I think it's important to, if you're metabolically healthy, to intuitively eat. So, when Kimla asks about some days when she has one meal versus other days she eats more than one meal, I think there's nothing wrong with that. In my estimation, one meal a day is exactly that one meal a day. When I think about Melanie's methodology and how she chooses to have like a wider feeding window, a wider eating window, I guess that's maybe the way to call it. I kind of differentiate that. I mean that to me is different. I think we can get caught up in semantics. I would say the same thing about when people ask, does this break my fast. We get nuanced and granular and everyone's stressing. I'm like, really what we should be focused on is determining how many meals do we need in our feeding window to get our protein in that's the first thing. I think that's very important for some people. If you're a unicorn and you can eat a huge meal and have 100 g of protein, more power to you. I'm not that person. I divide my food, my meals into at least two, if not three meals to get my protein in. 

Number two is I think it's important to vary what we do. I think most of us need to do that now. Do we have unicorns? Absolutely. That's a loving word when I say unicorn each one of us are individuals, each one of us needs something a little bit different based on our own needs or personal professional needs. And that's totally okay. Women that are still getting a menstrual cycle really should fast for their cycle. Women that are in perimenopause and menopause need to be careful about over fasting. I'm starting to see a lot of this women that are irrespective of life stage, but they are having very rigid rules about when they eat, how much they eat, a rigid fixation. 

I do think just one meal a day is a problem. I think it's fine every once in a while. Let me be clear what Melanie is defining as what works for her, she's getting plenty of protein in that feeding window. If you're just having one meal that has 30 g of protein, you are chronically undereating and that is something I get concerned about. There's zero judgment. Each one of us has to decide what works for our bodies. But if you're chronically undereating and you're chronically undereating protein in particular, and you are a woman north of 35 or 40, you are putting yourself at risk for metabolic inflexibility. That's what I want to just state. I recognize not everyone may like that opinion, but I do feel that it's important to at least interject. Can you get your protein in in your feeding window? Do I have one meal a day when I'm been traveling or maybe I went on vacation and I ate too much? Sure. But do I do that every day? No, but do we need to split hairs about OMAD? OMAD to me is one meal in a feeding window. It is not like a wider feeding window, like what Melanie does. To me, I don't think of that as OMAD. I just think Melanie has a gradual feeding window. How’s that? Is that a good way of describing it? 

Melanie Avalon: It's so funny. So, I guess, well first of all, super glad that you drew attention to, I think, the crux of the issue with the one meal day of getting in the protein intake. So, yes, that's definitely the major focus there. I guess the reason I feel, I feel like I'm having flashbacks to me and Gin talking, the reason I feel like mine is still one meal a day is, it's like being at a restaurant. It's literally a one meal situation. I start my eating. I'm like having the meal, it just happens to take, because I eat so much volume wise, this is all like whole foods, so it's all pounds of meat, pounds of cucumbers, pounds of blueberries, so it takes a long time to eat all of that. I like to eat slowly, so it's like eating one long slow meal. If you went to a restaurant and it was like a four-hour dinner type thing. 

That's why I feel like it's one meal because it's not like I'm having a snack and then not eating and then having a snack and then not eating, and then eating. It's like mealtime. If listeners are curious what I'm doing, I know people say that you should eat and just eat and focus on just eating, but I'm always reading two books at any one time, so I'm listening to one on Audible during the day to prep for the Melania Avalon Biohacking Podcast. I'm always listening to one during the day and then at night is when I read. I'm reading during those four hours and taking notes. That's why I feel like it's a meal situation. It really doesn't matter. It's semantics.

Cynthia Thurlow: No, I love that you have this whole process of creating digestive fire. You're starting kind of slowly and then building up to this crescendo and then it comes back down. For me, it's two boluses of food. I do know there are a lot of people out there that have differing interpretations of OMAD. It's not that one is right and one is wrong. I think that to me it makes sense to say OMAD is one meal, one food bolus. If you have two meals in your feeding window, great, but I don't think it should be a source of stress. Like ultimately eating less often should not be causing you more stress like really and truly. We have enough stress in our lives. We don't need to add more stress stressing about definitions of things. 

Melanie Avalon: I agree. I would comment that like an eight-hour eating window, like what Nancy is doing. I don't see how that would really be one meal. 

Cynthia Thurlow: Right, right. It really should be two. I mean, I'll give you a prime example. I traveled yesterday, I traveled this morning to come back from New York, and today is a much wider, fasting window because I literally have not been able to stop and eat. So, when I'm done with this podcast, I will go eat and I'll probably divide my protein into two portions because I'll probably eat a little bit and then a little bit more before I would close my feeding window just to make sure I get enough protein in.

Melanie Avalon: Got you. Yeah. That also goes back to knowing yourself and the unicorn comment and things like that. I do so well with just a massive, massive bolus of protein all at once. For a lot of people, I understand they can't handle that like they would need to separate it. So really, it's about knowing yourself. You commented on this. That's what I really love about Kimla's observation. She seems to be very intuitive with how she feels. So, yes. I think not getting lost in the semantics and like Cynthia said, stressing about the definitions and all of that. There's really no need to just focus on what you need to get out of your eating window.

Cynthia Thurlow: I think that's important because one of the things that I get the sense of is that there's anxiety around rules and there's anxiety around lifestyle changes. And that's definitely not what we want. We don't want to create more anxiety. We actually want fasting or digestive rest, like you do 12 hours of digestive rest. Like, it really should not be an added stress to your life. For those of you that are newbies, certainly lean in. There're so many great podcasts, like, over the last several years that Gin and Melanie did, and Melanie and I have been doing since May. And there's so much great information. Our books are great sources of information as well. Don't let it be a stressor. Just the concept of intuitive eating, intuitive fasting may not be accessible for everyone right now, but that's what we hope you get to a point where you can really lean into what makes your body feel good. 

You're an N of 1. This experimentation that goes on in terms of lifestyle changes. I know that the most I can eat in terms of a protein bolus is about 60 g. That's a good amount of protein for me in one meal. If I do 75, I'm probably going to be uncomfortable. So, 60 g is what I've been able to work up to but that didn't start right away. That was something I worked up to. We know most women are eating probably 40, maybe 50 g of protein a day. Most of us are not eating enough. Just be consistently working towards goals and that's the best that we should be able to do, right? 

Melanie Avalon: Yeah. I could not agree more. I find it so interesting, too. If I just ate, like, 40 g like you were saying, I would be starving, starving. Every time I go out to dinner, I get an entree, now it's my dessert, another round of meat. So good. So, so good. 

Cynthia Thurlow: I love that. It's funny Ben Azadi, who I know that you have recently recorded with, Ben, gets two dinners. And so, my husband the first time--

Melanie Avalon: Well, he does two. 

Cynthia Thurlow: Yes. Ben is, like, very tall and very lean. We were in Utah together, my husband and I, and his fiancée and Ben, and we're having dinner. And his fiancée, Natassia was like, “Watch.” And Ben's like, “I'll have two dinners.” And they were like, “What?” He was like, “Oh, yeah, we'll have two dinners.” And my husband and I were like, “What's wrong with that?" [unintelligible [00:55:49] one good-sized meal. 

Melanie Avalon: Does he have them at the same time or does he get them back to back? 

Cynthia Thurlow: Oh, at the same time. 

Melanie Avalon: Like I did on my birthday dinner. 

Cynthia Thurlow: Hmm-mm. And he ate it all. We were like, he's like a teenage boy, he has that capacity. I was like that's amazing. 

Melanie Avalon: I will get two entrees, or I will get an entree and then for dessert when everybody gets their dessert, I get another entrée. And I will say, so a little tip for listeners if anybody else wants to do this, I don't know if anybody else wants to do this. But especially if you're like keto or low carb, which I'm actually not, ironically enough, but it can be really fun to get an appetizer, like another round of sashimi or another steak for dessert. Let the kitchen know. If you're there late, they'll often shut down the entree part of the kitchen early. If you do want that for dessert, you need to let them know earlier on that you're going to be ordering that. Just a little tip for the one other person that wants to do this already.

Cynthia Thurlow: That's a good tip.

Melanie Avalon: They've cut it close sometimes because I've waited too long to tell them.

Cynthia Thurlow: [laughs] You also eat late at night, so they're probably like, “We're done.” Melanie's like, “No, I need more food.”

Melanie Avalon: Yeah. If you get an appetizer for dessert like the tartar, the carpaccio that comes from one part of the kitchen that might have shut down, and if you get an entree for dessert that comes from another part of the kitchen that might have shut down, the appetizer part of the kitchen is actually more likely to have shut down, I think. Now, I was thinking back to my serving days. That might not actually be true because oftentimes the dessert station is the same person as the appetizer station. In any case, the point is, ask your waiter or let them know. 

Cynthia Thurlow: Absolutely. 

Melanie Avalon: Should we answer one more question? 

Cynthia Thurlow: Sure. Our next question is from Spencer. Subject is “Breaking fast.” “Is there a proper way to break a fast? I feel like I want some items that are still a little unhealthy and seem to not really be losing weight on the scale. Maybe I need to also throw mine away but it got me thinking.” I'm assuming he's talking about the scale. “I keep hearing about there being a proper way to break a fast. Any thoughts on what I should be eating when I break my fast to provide me with the best results? I'm currently listening to the podcast and maybe haven't seen this question yet. Thank you.”

Melanie Avalon: All right, Spencer, thank you so much for your question. It's interesting because we have talked about this question on the show, seeing as how many episodes we've had, probably multiple times. But I think there's a unique spin we can give on answering at this time because normally when we have answered this question, I think it's been more in the context of how to ease your digestion, how to help heal leaky gut. Opening with things like bone broth and with gentle things you can digest. I don't know that I've given the perspective before of how to break your fast with specifically weight loss being the goal. And so, something that occurred to me is that and this is very individual, I think knowing how your body responds with insulin, you don't have to actually know the insulin number, but your perception of responding with blood sugar swings or not to different foods can be very helpful in the ordering of your food.

Because, for example, I mentioned before my order, my crazy order, oh, I'm so happy that we're answering this in here because this works so well together. The reason I do that order is very specific. It's what provides me well, hey, I can digest it well, but it provides me the most-- I always wonder, is it satiety or sha-city? I say satiety, right? But can it be both? 

Cynthia Thurlow: I say satiety, and I can assure you that after doing the audiobook for my book, the producer made sure that every word was enunciated and properly, I mean, everything. Yes, you say it correctly.

Melanie Avalon: Great. I have the most satiety with my personal pancreas and my personal insulin and my personal blood sugar regulation. When I open with the wine and cucumbers, like, that doesn't make me ravenous, it doesn't make me have blood sugar drops. Then I eat the massive amount of protein, which I find very satiating. The reason I actually eat a ton of fruit at the end is because I have found that mitigates what I either perceived as reactive hypoglycemia when I was doing low carb or might not have actually been reactive hypoglycemia. It might have been, we talked about it before, there's a name for it. I think it's like, idio--. It's basically feeling like reactive hyperglycemia, but it's actually not. You actually have normal blood sugar levels, but you feel like your blood sugar is dropping. When I was doing low carb and eating a mass amount of protein, I would be really satiated, and then I would go to bed, and then I would wake up starving. 

I think it was from my blood sugar probably dropping from the high protein intake. I do that pattern because it allows me to feel full, feel nourished and I don't get swings later. So, I think knowing yourself and experimenting to find what can you open your window with that will for you keep you full and satisfied, can be very helpful. For a lot of people, if they were to open with a simple carb-type situation, they might get a massive blood sugar swing that might make them ravenously hungry and make them overeat, even things like alcohol. Some people, the timing of the alcohol, depending on where it is, depending on their own alcohol metabolism, might make them eat more or less. Depending on that, the timing of if you're eating fat or not could make a difference. Basically, I would focus Spencer on finding the way that opens up the fasts that provides you with the most satiety.

Cynthia, what are your thoughts? 

Cynthia Thurlow: I am a fan of leading with protein into opening up your feeding window. Sorry, that would be my dog groaning underneath my feet, in case anyone's wondering. I think leaning into protein is important both for blood sugar support and also for satiety. For me, it's either protein and non-starchy carbohydrates, or it's protein and healthy fats, and that's typically how I break my fast. I just think protein is a really important macronutrient and one that I spend a lot of time talking about. I spend a lot of time discussing examples of protein and non-starchy vegetables. It could be chicken, it could be bison, it could beef. You could have arugula or spinach, or you could have broccoli or cauliflower versus sometimes when I sit down to have a protein and fat meal, it might be a piece of salmon, fattier cut of meat.

Those are the things I kind of lean into because it fulfills my needs in terms of getting my macronutrients in, but it also leaves me satiated. I can always tell if I haven't gotten those macronutrients right, because I will then be looking for more food when I'm done. But I think some degree of experimentation to find out what works well for you. I have some patients that want to break their fast with bone broth, others that want to take a light salad, like what Melanie does, where she has her cucumbers and her wine, and then she leans into the protein piece. I would do some degree of experimentation to find out what works best for you, but the protein is one that I always try to emphasize for most people.

Melanie Avalon: Okay, well, this has been absolutely wonderful. A few things for listeners before we go. If you would like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can get all the stuff that we like @ifpodcast.com/stuffwelike. And you can follow us on Instagram. We are @ifpodcast. I am @melanieavalon. Cynthia is @cynthia_thurlow_. That is all the things. Anything from you, Cynthia, before we go?

Cynthia Thurlow: No. Super excited for our upcoming recordings together and I look forward to getting feedback from listeners.

Melanie Avalon: Likewise, and because of when this comes out Happy New Year to you. 

Cynthia Thurlow: Happy 2023, hard to believe.

Melanie Avalon: I know. It's crazy. I'm excited for it, though. 

Cynthia Thurlow: Me too. 

Melanie Avalon: All right, I'll talk to you later.

Cynthia Thurlow: Sounds good.

Melanie Avalon: Bye.

Thank you so much for listening to The Intermittent Fasting Podcast. Please remember everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

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Dec 18

Episode 296: Berberine, Insulin Sensitivity, Glucose Control, Gut Health, Liver Health, Body Recomposition, AMPK Activation, Cholesterol Control, And More!

Intermittent Fasting

Welcome to Episode 296 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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SHOW NOTES

JOOVV: For A Limited Time Go To joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

scotts backstory

GMP certified

Episode 265: All About Supplements With Scott Emmens, The Supplement Industry, Purity, Potency, Testing, Toxins, Authenticity, Organics, Common Additives, And More!

Continuous glucose monitos

Go To melanieavalon.com/nutrisensecgm And Use Coupon Code MelanieAvalon For $30 Off!

metformin

combining berberine with metformin

the types of anti-diabetic medications

the benefits of berberine

what is berberine?

AVALON MAGNESIUM 8: Use The Code Melanieavalon For 10% On Any Order At Avalonx.Us And MDlogichealth.Com!

the history of berberine

the effect on the GI tract

dosing

The Melanie Avalon Biohacking Podcast Episode #93 - Shawn Wells

The Melanie Avalon Biohacking Podcast Episode #166 - Megan Ramos

the contraindications

meal timing

body Composition

AMPK activation

positive effects on the liver

dihydroberberine

LMNT: For A Limited Time Go To drinklmnt.com/ifpodcast To Get A FREE Sample Pack With Any Purchase! Learn All About Electrolytes In Episode 237 - Our Interview With Robb Wolf!

the journey of creating the supplement

purity testing

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 296 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time and get ready for The Intermittent Fasting Podcast.

Hi friends, you guys know how seriously I take my health routine. That is probably the understatement of the year. One of my literal non-negotiables that I talk about all the time that I use every single day of my life is getting my daily dose of red-light therapy. For years now, yes years, I've been using Joovv and I love it because it is so relaxing and so easy to use. You've probably heard me talk about Joovv before that's J-O-O-V-V. I use my devices daily to support healthy cellular function, which is the literal foundation of our health. If you've heard any of my episodes on mitochondrial health you know this is true. Having healthy cellular function helps give me peace of mind that my body is working efficiently and has the energy that it needs to get through the day. There are so many clinically proven benefits from red light therapy and I have personally so experienced many of them. I use the red light to naturally regulate my circadian rhythm. I wind down with it at night and wake up in the morning with it. Whenever I have any muscle pain or soreness. I shine my Joovv red light on it and the pain instantly goes away. It's actually shocking. I love it for skin health, it makes my skin glow. And you can also use it for things that I originally got into red light therapy for which was supporting my thyroid. Yes, I struggle with hypothyroidism and supporting hair growth. Aside from the benefits, I've been recommending Joovv for years because the quality of their devices is simply the best. Their modular design allows for a variety of setup options that gives you flexibility plus the treatments are easy and can be done in as little as 10 minutes. Although I tend to run mine all day as ambient light. All you have to do is relax and let your body take in the light. Joovv offers several different size options including a wireless handheld device called the Joovv Go. That is amazing for targeting specific areas around your body like hurting joints or sore muscles.

When I traveled recently and had torn something in my knee, I brought my Joovv Go with me, game changer, I don't know how I would have survived the trip without it. Health doesn't have to be complicated and Joovv makes it simple by helping what matters most, our cells. So, go check out the Joovv today and while you're there, Joovv is offering all our listeners an exclusive discount on their first order. Just go to joovv.com/ifpodcast and apply the coupon code, IFPODCAST to your qualifying order. Again, that's joovv.com/ifpodcast with the coupon code IFPODCAST. Pick up a Joovv today, some exclusions do apply and we will put all of this information in the show notes.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream.

And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of future generations. That's because ladies when we have babies, a huge percentage of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years.

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life and their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out. You can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well. 

And lastly, if you're thinking of making clean beauty and safe skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like the Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally completely worth it. So, again to shop with us go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now, back to the show.

Hi everybody, and welcome. This is episode number 296 of The Intermittent Fasting Podcast. I'm Melanie Avalon and I am here with a very special guest today, quickly becoming a crowd favorite. I am here with Scott Emmens. He is the chief operating officer and cofounder of MD Logic Health, which is an incredible supplement company that you guys are quickly becoming very familiar with because they are actually my partner in bringing you AvalonX. So, serrapeptase and magnesium that we've had and Scott is back here today. Well, first of all, because he's basically one of my favorite people in the entire world and I mean that from the bottom of my heart. But secondly, I am thrilled that we are about to launch-- actually when this comes out, we will have just launched my third AvalonX supplement. And it is something that I already personally had been taking every day in my life. Not only that, but it's something I've talked about on this show so, so much. Since this show is The Intermittent Fasting Podcast, it is something that really relates to metabolic health, blood sugar levels, how well you can do your fast, and then on top of that so many other health benefits that I actually didn't even really realize until sitting down to make my own version of this supplement. And that is berberine. I've been looking forward to this episode for a long. Scott, thank you so much for being here.

Scott Emmens: Hi, Melanie, thank you for having me on the show. I'm thrilled to be on and even more excited that we're you're finally launching berberine.

Melanie Avalon: I know, I feel like this has been such a long time coming. Okay, a lot of our audience is probably familiar with you because you've actually been on the show twice before you came on. We did a whole episode on magnesium with Cynthia. And then more recently, you did an episode with Cynthia for her creatine supplement because Scott also partners with Cynthia for her supplement line. Basically, we just really love Scott. But for those who are not familiar, Scott, super briefly, could you tell your backstory?

Scott Emmens: Sure, for those folks who may not have heard the first podcast when we went through that. I was in the biotech and pharmaceutical space for 25 years in a variety of positions, in marketing, sales, and sales leadership. I eventually got out to manage market side as well as operations and operational side. I really basically worked at some of the biggest pharma companies that people have heard of Takeda Pharmaceuticals, AstraZeneca pharmaceuticals, which was at the time part of Merck, Shire, and then became a startup expert, and worked my way into the C-suite of multiple pharmaceutical companies. And I really kind of around 2018 decided I was going to start my own biotech company and did that, very successful and literally right around 2020, when the pandemic first started, I'd decided that I really wanted to get into the wellness space. And we had sold our biotech company and I had three partners. And we decided, my partner and I, at the time thought, "Let's do a wellness line, make a wellness company." We had a connection with one of the largest US manufacturers. He is a partner in MD Logic as well. And we really just both believed in making people and keeping people well and letting them optimize their life through supplemental nutrition.

Melanie Avalon: Yeah, that's something that I really, really love working with you is you have seen the industry side of things. You know what you're doing. I have learned much and creating the supplement line, just what goes on in the supplement creation world, and how creating our own supplement line that is not a pharmaceutical, how it compares to that. And also, all of the crazy practices that go on in this industry it's a little bit shocking.

Scott Emmens: Yeah, it can be and I think that's where my pharmaceutical background really helps is making sure that we're going to do everything by the book. And by the book meaning people often see GMP on their label, it'll say GMP or GMP certified. And what that stands for is "Good Manufacturing Process." That's a compiled document from the FDA of very specific things you need to do, both in terms of the manufacturing of the product, the storage of the product, the cleanliness of the machines, the raw ingredients, the testing of the raw ingredients, as well as a number of other things including how you label even down to the font size of the label. And then including, of course, what you say about the product and how you make claims and that's where people tend to get in trouble.

We try to make the absolute best product we can. We have a great process for GMP. We have been audited by the FDA as most GMP companies are about every other year or so, and have a pristine track record and I am here to make sure that your supplements and MD Logic health supplements maintain that pristine record of both incredible quality, testing, and maintain the highest standards of GMP or above.

Melanie Avalon: Yeah, I am do grateful for this because honestly my goal in making supplements was, I knew I wanted to make the very best on the market. And it has been so refreshing to have a partner like you who is in line with that. And even every time I send my emails or I'm creating my content to promote the different supplements, I've come up with my list of basically the qualities about the AvalonX supplements. I say at the beginning that these are the only supplements on the market that are all of these things. And to my best of my knowledge, that's true. They're the only ones that are tested multiple times for purity and potency, free of all allergens. Scott and I have gone to great lengths to get rid of problematic fillers from the supplements, which has been a whole journey on its own, especially revisit, I'll put a link to it in the show notes the episode that we did on--. No, wait, "We haven't done the episode and serrapeptase yet, did we?" I think we talked about it though.

Scott Emmens: I think we did talk about it? But I've to go back into my memory log. But I believe we did talk about the serrapeptase, yeah.

Melanie Avalon: Did you come on this show for serrapeptase?

Scott Emmens: I think this might be my third appearance. I think I did do the serrapeptase first, then the magnesium, and then creatine. Yeah, I think serrapeptase was the very first one.

Melanie Avalon: My bad. So, this is your fourth time back?

Scott Emmens: Oh my goodness, how time flies. [laughs] 

Melanie Avalon: Oh, and you're having fun. [laughs] Okay, wait. In any case, listen to the serrapeptase episode if you want to hear the craziness with the fillers and the lubrication agents and also something that's incredible that really I think makes us stand apart is they are in glass bottles, which is very rare and unique in the supplement world. It's just been an amazing journey. "Shall we talk about our berberine journey?"

Scott Emmens: Let's talk a little bit about the berberine journey, I think the audience would love to hear what transpired? Why did it take us so long? And yeah, why don't you kick it off now?

Melanie Avalon: Okay, I started taking berberine when I started wearing something that our listeners are probably pretty familiar with which is the continuous glucose monitor. Just briefly a continuous glucose monitor is you put it on your arm, and it gives you a basically 24/7 look at your blood sugar levels. It is so eye-opening, so fascinating. Because when you're getting just doing a finger prick or yeah, a finger prick or blood draw for your blood glucose that's really just a snapshot in time. And it's not very telling of what is happening consistently. If listeners who like to get a continuous glucose monitor, you can go to nutrisense.io/ifpodcast and the promo code IFPODCAST will get you $30 off any subscription program to a NutriSense CGM, so definitely check that out. But in any case, doing a CGM really made me look more at my blood sugar levels and that's when I wanted to see what I could do to help lower it.

Berberine is considered to be the go-to "Natural Supplement" to address blood sugar levels. The go-to pharmaceutical to address blood sugar levels is metformin. There have been multiple studies comparing metformin to berberine and finding similar effects, which is incredible. So basically, berberine can be comparable to metformin in lowering blood sugar, lowering HbA1c, which is a longer term picture of your blood sugar levels and also lowering insulin without any of the potential side effects of metformin or the other negative side effects that can come with other metabolic health blood sugar controlling agents.

Scott Emmens: Certainly, I think that's absolutely correct. One thing we want to caution and make certain that we're not giving medical advice nor are we suggesting that anyone replace their metformin with berberine, not at all. What we are saying is that berberine has some remarkable properties and there's a lot of data, in fact, it's one of the most studied herbs or alkaloids out there. And we really feel passionate about all the benefits. In fact, I was stunned to see how many benefits there are with berberine as we really dug into the research, but again, we just want to caution, never add anything or take anything away, especially metformin for diabetic patients. So, just want to make sure that that's perfectly clear.

Melanie Avalon: Oh, yeah, I'm so glad you said that. And that's actually really appropriate because we got a lot of questions about that, Karina said, "How is it different than metformin?" Marie said, "Can you take it while taking metformin?" and Lea said, "Can it be taken if one is already on metformin, can it be taken instead of metformin?" So, just to dive deeper into all of that and to what Scott just said? Metformin as well as some other drugs that are used for similar purposes can have side effects. Metformin notoriously has gastrointestinal discomfort. Metformin cannot be used by diabetics or liver disease, renal impairment or cardiopulmonary insufficiency, and then some other related drugs like I don't even know how you say it. Is it pio?

Scott Emmens: Pioglitazone. I know that one because I sold it.

Melanie Avalon: I was like "Scott probably knows it."

Scott Emmens: Pioglitazone or pioglitazone.

Melanie Avalon: So, that one can increase the risks of distal bone fractures, bladder cancer, and edema. Here's another one Scott, sulfonylur--

Scott Emmens: Sulfonylureas?

Melanie Avalon: Yes, yeah, that was linked to hypoglycemia, weight gain, and cardiovascular damage. When we compare this to berberine, very little if any side effects, some people do have some GI issues potentially in the beginning, which we can talk about. But we can definitely dive into that. Because ironically, even with GI issues, berberine has a ton of potential benefits for GI Health. But besides that, you basically get all of the benefits of blood sugar control with a myriad of other benefits that we're going to talk about without the potential negative side effects of these pharmaceuticals. And there have been like Scott said, "We are not saying to stop your medications. We're not saying to even add this to your medications, that's something you would want to talk with your doctor about." Anything that you're doing, playing with your medications, definitely work with your doctor. That said, there's actually been quite a few studies looking at berberine in combination with metformin and finding beneficial effects, potentially that it might be a better approach, not saying to do this, work with your doctor. But potentially that combination therapy might be better than metformin alone because you can get more of the benefits with less of side effects.

Scott Emmens: Just going to add to that to just make sure that people make certain that if you add berberine to an antidiabetic, it can cause hypoglycemia. That's something you want to be cautious. Whatever the side effects of your prescription medication are, you want to let your physician know that you're going to take berberine and get their permission, make sure that the drugs you're on are not going to interfere with it because some drugs can have hypoglycemia on their own, when you add something like berberine, it can increase that potential. That's something people have to be very cautious of. Hypoglycemia can be a life-threatening condition as those folks who've had it know. It's interesting Melanie, the three drugs you mentioned, metformin which is sort of the gold standard, about 80% of diabetics are taking metformin or what used to be called Glucophage, the brand name, pioglitazone or TZD as they're known, which is an insulin resistance molecule, works on PPARalpha and PPARgamma. And then you mentioned was sulfonylurea which actually works on the pancreas to secrete more insulin. So, each one of those works differently. Metformin primarily works on the liver preventing gluconeogenesis and a little bit of insulin resistance. Then there's a TZD class pioglitazone, that works primarily on insulin resistance. And then there is some sulfonylurea class which increases your pancreas' output of insulin. They all work in different ways and they can all have different interactions with berberine, so again always talk to your physician. I think the real benefit Melanie is that berberine doesn't-- you don't have to have high blood sugar or you don't have to have diabetes to benefit, in fact, the real benefit we want to talk about today is what is the benefit for just people in general that want to optimize their health and optimize their cellular function and their energy. And that is where berberine shines.

Melanie Avalon: First of all, that was highly impressive, that you knew all of that. [chuckles] "I'm so impressed." Okay. Yeah, I'm so glad you said that because that is the exact same page that I'm on. And like I said, I came to it originally for blood sugar control and I think that's why most people think about it and it's a great reason to take it, but there are so many other benefits like whole body benefits. So, the questions we had, very simple, Kersey said, "Why do I need it?" Jennifer said, "What are all the benefits that come from taking it?" Amy said, "Will it help with insulin resistance?" And then what we will also get into Paul said, "Wondering what other health benefits it offers besides blood sugar regulation?" Andrea said, "Does it have any other benefits besides preventing lessening glucose spikes." So, we can dive deep into all of that. But to start off, I would like to give an overview of how it does work for blood sugar control because I think that really speaks to why it can be really beneficial to take when you understand that it's not like a pharmaceutical where-- With the pharmaceuticals they typically have a more singular approach to why they're working, compared to berberine that has all of these effects that can create this metabolic health.

For the blood glucose control, like Scott had mentioned it can be used for addressing insulin sensitivity and reducing blood sugar. It's so interesting because there are many studies. I had much fun preparing for this because there are many different hypotheses for how it's doing that. One of the main mechanisms and Scott mentioned this is that directly in the liver, it actually can reduce the liver's ability to actually create glucose or like create glucose and release it into the bloodstream. Because a mind-blowing fact-- I remember when I first learned this and it blew my mind because I think most people don't realize this, is that when people have high blood sugar levels most people think it is from what they're eating, which it is, but the actual, like 24/7 higher blood sugar levels, that's mostly being controlled by your liver. So, it's your liver creating glucose and releasing glucose.

Berberine actually inhibits that, it reduces enzymes directly in the liver that do that process, so then it can't happen. And interestingly, they have found that even though it helps insulin sensitivity, it doesn't seem to actually affect insulin production in the liver, so it's working independently of that which is really interesting. It can actually be directly in the gut reduce intestinal glucose absorption. So, just starting at the very beginning, it can stop the glucose from actually entering the body in the first place and that's by inhibiting a specific enzyme called a glucosidase activity. And that's an intestinal enzyme that actually digests carbs and converts them into more simpler sugars. Stopping that keeps you from actually absorbing some of those carbs in the first place. And then, beyond all of those enzymes and such it also can actually affect the transport of glucose throughout the body. And then on top of that, we can talk about the gut health potential of it. But a lot of researchers have hypothesized that its beneficial effects on the gut microbiome actually have a secondary effect of blood sugar control by the metabolic health state that is created from that so the anti-inflammatory state, the encouraging of short-chain fatty acid butyrate-producing bacteria when butyrate is created and gets into the bloodstream, it actually can help with glycemic control and the reduction of inflammation in the gut from endotoxin and LPS and the recruitment of macrophages and I realized I say all these words really fast and I know what they mean, but people might not know what they mean, so that's basically like the toxic byproducts that are created from "bad bacteria," because I realized saying good and bad bacteria can be a little bit simplistic. It reduces the inflammatory potential of the gut and inflammation is a key driver in metabolic issues. I can stop there a little bit. So, you want to jump in at all, Scott?

Scott Emmens: Well, first of all, great, I think it's a fantastic overview. And you can see how many different complex mechanisms berberine appears to have and why it has a broad base of positive impact across a number of organs and organ systems and then in particular blood sugar. I think we're going to learn a lot more as this molecule is again becoming, I shouldn't say molecule, this plant alkaloid is becoming hot on people's radar again. And I think at the end of the day, insulin is such a powerful hormone that when you can maintain blood glucose, which your audience is all about, the intermittent fasting audience really understands what blood glucose is about. But I don't know that we talk about the power of insulin and how powerful it is. I don't know if berberine lowers your fasting insulin and/or postprandial insulin meaning after a meal. My guess would be yes because it's lowering blood glucose with people that are already in normal ranges, well, then it's going to probably lower your insulin.

And we know in the presence of insulin, it's more difficult to burn fat, so it's all these different ways in which it slows the breakdown of glucose, it slows the liver's export or gluconeogenesis creating new sugar to push out into the bloodstream. All of the different mechanisms I think are fascinating and the more we learn about it, I think the more we're going to realize that this compound is going to have some very significant overall benefits for your wellbeing on a number of different organ systems.

Melanie Avalon: I'm glad you said that. Two things to comment on, the insulin piece. I did find studies showing a reduction in insulin. It was once where they were comparing it to metformin and they were looking at the long-term effects of that. And then there are so many studies talking about how it increases insulin sensitivity, that is definitely happening. But I'm so glad you said that because we probably should start with a really important question or we should get to a really important question. Jennifer said, "What is it? Is it a plant, a fruit, etc.?" April said, "I know serrapeptase comes from silkworms, but where does berberine come from? When did people start using it?" I realized we were saying like we haven't really defined what it is. So, it is a plant alkaloid and Scott, would you like to talk about the plant that it comes from? And why we chose the one that we chose?

Scott Emmens: There are different forms of berberine based on the plant source that it comes from. The one that's being used in our Vedic Medicine in India and is usually the form that is used in most of the studies you're going to see and I hope I pronounce this right, but it's Berberis Aristata I believe and that's spelled B-E-R-B-E-R-I-S A-R-I-S-T-A-T-A and that is the form that we've used and that comes from the Indian barberry tree or shrub and it is a shrub that belongs to the genus Berberis and it is found specifically in India. And there are many different species of this shrub. And it's typically found in the Himalaya area of India and Nepal as well as other places in Sri Lanka and that is the form that we’ve utilized.

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Do you know when they started using berberine?

Scott Emmens: I'm going to take an educated guess-- Because our Vedic Medicine goes back a while, I'm going to take an educated guess and say 1500 years ago.

Melanie Avalon: 3000 BC.

Scott Emmens: Wow.

Melanie Avalon: To treat diarrhea and dysentery. That's like when I very first started, isn't that crazy? That has a long safety record, I will say [chuckles] which we can circle back to.

Scott Emmens: So, I was only off by 4000 years, not bad. [chuckles]

Melanie Avalon: It probably got upregulated more little bit later when it first appeared. And like I said, that was to treat diarrhea and dysentery. And just to circle back a little bit to the GI Health aspect to really fill that out. There's been many studies on berberine and its effect on gut bacteria. And actually, we have a question about this, so I'll just tie that in right now. For example, Nikki said, "I've heard people say not to take it daily because it changes your gut bacteria, what are your thoughts on that?" Morris said, "This would be my question. I always cycle on and off of it, but I know Melanie does not?" And then Karen said, "Berberine is used as an herbal antibacterial/antimicrobial, which I was going to get to, so I'm glad she said that." She said, "In addition to the blood sugar lowering properties that you are focusing on, I'm concerned about negative effects on beneficial gut bacteria with regular use of this product, can you speak to that?" I'm super happy that people were asking me about that. There have been a lot of studies looking at its effect on gut bacteria populations, and across the board it tends to increase the "Positive good bacteria, specifically Bacteroides and decrease the more inflammatory bacteria specifically Firmicutes." Because those are the two that if you know about gut microbiome, you might have heard of them before, but there's been a lot of other studies, for example, it's directly antibacterial against E. coli and clostridium difficile. It can increase, I mentioned this earlier, the short-chain fatty acid-producing bacteria, specifically and I don't know if I'm going to say these right. Phascolarctobacterium, Anaerotruncus, and Acidobacteria, those are all short-chain fatty acid-producing bacteria that can help with intestinal integrity. And it also may inhibit a certain type of bacteria that has been connected to obesity, which is super cool. And we can actually get into the obesity, body fat bit in a little bit. Basically, it seems to have a very beneficial effect on gut bacteria. I would not be personally and again you can make your own decisions and choices, but I personally am not concerned about the effect because it seems to have a very beneficial effect. I actually wonder, Scott, I'd be curious about your thoughts on this, I hypothesize that people who might sometimes be experiencing negative side effects in the beginning, it might be because they are playing with the populations of their bacteria and are experiencing a die-off effect because whenever you go after the bad guys, you can get negative side effects from that. It's a good thing because you are moving the needle towards more beneficial population. There might be some side effects in the interim. And, for example, I found there was one study looking at berberine compared to metformin and it found that all of the side effects only happened in the very beginning of the trial, and there's a longer-term trial. if you are experiencing gut issues in the beginning, I would suggest maybe lowering your dose so we can talk about this later and maybe sticking it out a little bit. But Scott, what are your thoughts?

Scott Emmens: I think your hypothesis is a pretty good one. Meaning anytime you're detoxing the body even if detoxing is a "Good Thing, " you know that you're killing off a lot of bad bacteria, and maybe you're not using a binding agent or you've got a lot of bad bacteria in your gut that could cause inflammation, the destruction of those can release toxins. Yeah, that could very well be, I think, that's a little speculative, but it's a reasonable theory. But what is pretty consistent is that the metformin side effects and the berberine side effects both seem to happen upfront. And the solution to that in the Glucophage world, is what doctors will say and many patients have probably heard this wording "Start low and go slow." if you are sensitive, you've never taken berberine before or you take two pills on day one and you feel a little bit of GI upset then back down to one capsule 500 mg once a day, kind of stabilize yourself and then you can work your way up. And that's really, I think, always goes for any medication or supplement, you always want the lowest effective dose. Now, we came out with the 500 mg, had a lot of discussion about what to recommend in terms of dosing, one to three capsules a day is where it landed because the majority of the data suggests that on the low end, 500 mg is right. On the higher end, 15 mg is correct. Many of the studies have been done with 500 mg three times a day, I don't think you want to take 1500 in one shot, really, you want to break that up over three doses. But that's where we found the sweet spot was. So, if people are experiencing side effects, I would say start with 500 and just slowly work your way up.

Melanie Avalon: Yeah, I'm so glad you said that because we had had obviously a lot of questions about dosaging, like Jennifer said, "How much can or should I take?" Claudia said, "How much to take? What's the dosage?" Anna Maria, "When is the best time to take it to optimize results?" Amy, "Is it best to cycle it or take it every day? Should one take it at the same time every day or time it more specifically to be ingested before you eat a potentially glucose-spiking meal?" Cheryl wanted to know "Do you take it with food or on an empty stomach?" And Nydia wanted to know "Does it break the fast?" Teresa also wanted to know "Is it something that you can take daily? I know Shawn Wells listed as one of his most recommended supplements. But I've heard Cynthia Thurlow say that she has people cycle it. I will put a link in the show notes, by the way to an episode I had with Shawn Wells on the Melanie Avalon Biohacking Podcast. I adore Shawn and he is one of the go-to people in the supplement world, he's just a phenom when it comes to that, but yeah, to answer all of those questions, Scott just gave a really nice overview of the dosage and we thought long and hard about what dosage to do for it more. Again, going back to what we talked about in the beginning about the craziness with regulations. It's crazy how you have to like figure out what you can actually say on the label to get the dosage that you want. It's hard to describe. But basically, I had a very clear idea of what I wanted to say. And it had to go through Scott and like the legal team to get it on the label the way I wanted it.

Scott Emmens: That is correct. And I think, that's why we take those precautions because it's important for the public to make sure that what we're saying is in line with what is appropriate, but also to make sure that we're following all of the guidelines, guidance, and making sure that we are in compliance to that. That comes from 25 years of pharmaceutical lawyers pounding into me what I can't say. I want to make sure we do that, but on the other side, it's also what is it that we can say that will really make sure we're giving a clear specific guidance that is in the best alignment with what the data and the research suggest. And I think we got there and I think to your frustration, Melanie, I think a lot of people assume that the supplement world is a free cowboy world. But there are very stringent guidelines on labeling, claim that you make on that label, what you can say, what you can name it. And even down to like, the font size and how you list the ingredients and what size, certain ingredients have to be in the font size. I mean it gets very particular. So, again, going back to this, "What is GMP?" If you're following CFR 21, which is the regulations on how you label a supplement properly along with what this GMP mean, it's extensive and I think that's been one of the learning lessons that you have come across as well. How many things you have to do to make sure you've done it? But then again, how many other companies want to escape that edge that goes 75 and a 65 and make sure they don't get a ticket. And we'd rather go 65 and 65, then do the 75. And I think that is an interesting learning from a lot of people that we work with in this space, physicians [unintelligible [00:39:42] and so forth.

Melanie Avalon: Again, just another reason I've been grateful to work with you because you get all of this and I have learned so much, and it's just really been a really amazing incredible experience. So yeah, the dosage we landed on that we mentioned is based on the majority of the study. Probably the majority of the studies are 0.5 g or 500 mg, those are comfortable three times a day. But it ranges from, actually in the studies it's not normally on the lower end, but it can be, so I wanted it to have it, a minimum of like 500 mg up to 2 g, which seems to be the upper limit. That's the way we had it working on the bottle so that it could cover that range. I will say-- because we got a question because I had Megan Ramos on the Melanie Avalon Biohacking Podcast, she's amazing, definitely listen to that interview with her. She shared a negative experience she had with berberine experimenting with it during pregnancy, I think.

Scott Emmens: Yeah, that's a no, no.

Melanie Avalon: Yeah, and she was taking 2 g which again is the upper limit of that. For example, Lucy said, "Megan Ramos mentioned a few times that she was very sick with a negative reaction to berberine when she was on the Melanie Avalon Biohacking Podcast. I would like to know the main contraindications for berberine and how to avoid similar situations." Again, in that situation, revisiting that episode, Megan was taking the upper limit and while she was pregnant, I would start not at the upper limit, not take it during pregnancy or work with your doctor. So, definitely, you just want to be aware of all factors involved.

Scott Emmens: So, here are the contraindications, there're a few but they're fairly rare except for pregnancies. The first one is, if you're on Cyclosporin-A, you do not want to take berberine because it can have an interaction with the CYP43A for enzyme in the liver. Then you also do not want to take berberine with warfarin or thiopental, I think I'm saying that right, thiopental or tolbutamide because it can displace them from increasing the blood and increase the blood toxicity of those particular drugs. Warfarin has what's called the very narrow therapeutic index. Some of these other drugs do as well. If you increase just their bioavailability a tad or decrease it a tad it either will become toxic or can become ineffective. Those are contraindications. And then macrolide antibiotics such as azithromycin and clarithromycin may also interact, they're not contraindicated, but they are certainly something that you do not want to take berberine with unless you absolutely had to, based on a physician recommendation. And lastly, we do not want to take berberine if you are pregnant, that's contraindicated as well.

Melanie Avalon: Yes, I'm glad we could speak to that as far as does it break a fast? No, it will support your fast if anything. I actually don't take it the way most people take it. Well, first of all, I'm not eating three times a day. I'm not taking it three times a day before meals, I actually take it in the morning in the fasted state. And then I actually don't take it later before my meal. Although I probably should experiment with doing that come to think of it that would probably be beneficial. The reason I was doing that was I was just seeing the biggest spike in my blood sugar in the early part of the day, but you can really experiment and find what works for you. But typically, people are taking it before meals. Yeah, do you have any thoughts about that, Scott?

Scott Emmens: If you have a CGM, you want to experiment with that or if you take your blood sugar through another means, I think you want to experiment with that. For me, personally, I'm going to take one probably on an empty stomach starting when I start my new regime in January. Typically, when I take berberine, it's going to be about an hour to an hour and a half before my meal because I want to get the berberine inside my intestines, I want it to be metabolized and we're talking a little bit about the metabolites and the active metabolites of berberine. I think about an hour to an hour and a half prior to my meal to ensure that the maximum blood plasma level is there and that the metabolites are beginning to get into my system. That to me seems reasonable. Now, if you have GI upset, it's probably going to be the best to take it closer to your meal. I think you want to experiment with that both from a what's most comfortable for you? And then if you have the ability to measure your blood glucose, what's working best for you? For example, there's someone who owns a CGM company, he has a podcast. I've just listened to his podcast in preparation for the show and he had some limited success with berberine pre-meals. 

Now keep in mind, this is someone who is on a very restricted diet, he understands insulin, he's probably already in a low-insulin, low-glycemic state to begin with. He didn't see a lot of change with berberine before meals, but when he took it for the fasting insulin in the evening, he noticed dramatic decrease in his fasting insulin in the mornings. And that speaks to the liver part of gluconeogenesis because your liver's job with gluconeogenesis is to keep you from going into hypoglycemia while you sleep. And when you are diabetic or you have blood sugar issues that are beginning, your liver might be getting the wrong signal thinking, "Hey, we don't have enough glucose." So, it's pushing glucose out even though your glucose is already very high. So, based on the various ways that seems berberine works, I think each person's body type and where they're at, it's going to have a different impact, my personal recommendation for me is going to be to try to start taking it on an empty stomach, hour and a half before meals is what I currently do. And then I might experiment with a pre-evening dose.

Melanie Avalon: I'm so glad that you mentioned body fat. I know you're talking about it in a little bit different context. But I do want to talk briefly about the super cool effect that berberine can potentially have on body composition especially because I know a lot of people-- one of their main goals, possibly why they're listening to this podcast is for body composition effects. And there's been a lot of studies looking at berberine's effect on body re-composition with or without weight loss. So, it seems that in particular berberine can actually reduce the levels of inflammatory fat specifically, so visceral fat is a type of fat that is found surrounding the organs. And it's actually the type of fat linked to metabolic health issues compared to like subcutaneous fat, which is found underneath the skin and which is considered to actually be more benign when it comes to health issues. So, berberine has been found in some studies, it leads to weight loss specifically reducing visceral fat and in some studies, there's actually not weight loss, but there is a shift in the type of body fat, which is super cool. Basically, it's making your body more healthy when it comes to fat. Mice treated with berberine have actually been found to have shrunken adipocytes. Basically, their fat cells are smaller which is super cool. Other studies basically propose that the anti-obesity activity of berberine can involve in part not only decreased size of lipid droplets but actually also the number of lipid droplets. There's a study suggesting that berberine actually increases thermogenesis in brown and white tissue.

Scott Emmens: Yeah, that was very interesting to me.

Melanie Avalon: Yeah, basically increasing burning calories in your fat tissue, which is very cool, because you really want to stack especially with our modern diet environment, you want to do everything you can to stack the cards in your favor, to have a healthy metabolic profile when it comes to body fat. And it can be hard to do that, especially when there are cellular mechanisms involved. And anything that can really affect that, like berberine, can definitely be something to try. It can also discourage the creation of new fat cells "super cool." And that's actually by affecting transcripts and factors that are involved in creating fat cells in the first place. And then, for example, a review of five studies that encompassed 1078 women and you know I love when we got studies in women, found that it did indeed induce a redistribution of fat tissue, specifically reducing that inflammatory visceral fat that I spoke of. And speaking of the inflammatory potential, not only is it reducing the amount of inflammatory fat, it actually may make fat in general less inflammatory by reducing the recruitment of macrophages to fatty tissue. So, macrophages are basically-- for these things that go in-- and you can think of them like Pac-Man, they go and gobble up things. They're good, we want them in our bodies. They deal with getting rid of waste and fighting pathogens and things like that. But when you have an overabundance of them, it can be a very inflammatory state. And a lot of people's resistant fat, when people really just struggle to burn fat. It can be because the fat itself has become inflammatory, and it becomes resistant to fat burning.

Scott Emmens: Are you referring to brown fat versus white fat in adipose tissue?

Melanie Avalon: It found that it activated thermogenesis in both of them which is super cool. Did you find one showing that it increased brown?

Scott Emmens: Yes, I found a few studies that say that berberine promotes the recruitment and activation of brown adipose tissue in mice and in humans, which was pretty interesting. There was another study about berberine-activated thermogenesis in both white and brown adipose tissue, but one of the things I thought was so interesting was that it does seem it can help your body promote brown fat, thus thermogenesis and brown fat is packed with mitochondria. It keeps you from shivering, that's why babies have a lot of brown fat versus white fat, white fat that being the inflammatory version, brown fat being more of what they call an activated fat which has its own mitochondria in it and really actually is more of a positive energy-burning fat than white fat is. So, that I found really interesting. And even so to get to your point, if you don't lose weight, if you're just shifting that fat from the more inflammatory to the less inflammatory, more highly energetic fat, I think you're going to reap a lot of benefits.

Melanie Avalon: I'm so glad you said that, you really revealed that you haven't a grasp of what's going on because brown fat and white fat like Scott mentioned, brown fat is really high in mitochondria, it's activated by cold is something that activates it, it actually helps you lose weight which is ironic because it is fat, but it creates heat. And it basically wastes energy. But the thing that you said, Scott that I mean, I already knew this, but maybe made it aware that you actually really know what you're talking about. I think a lot of people think brown fat and because they associate it with cold, they think "Oh, that's like shivering," but it's not, it actually keeps you from shivering because the alternative to brown fat is to shiver, basically.

Scott Emmens: Exactly, and do you know how I know that, Melanie?

Melanie Avalon:  No.

Scott Emmens: Ice baths have taught me that. [laughs]

Melanie Avalon: I was going to say cryotherapy.

Scott Emmens: Yes, I am an ice bath guy. And I'm about to embark on a January 1 through February Polar Plunge for mental health benefits. I am currently back in training filling my tub up with giant hunks of ice and getting in there for 10 minutes or so to adapt. And I discovered the benefit of brown fat as I was really-- This goes back to 2016 when I first began doing ice bath, which by the way changed my life in so many ways. But that's when I discovered what brown fat was, why it was important and how I adapted to the cold over time by creating more of this brown fat. I mean, the first time I got in an ice bath, it was 60 seconds of pure shivering and agony. Three months later, I could sit in there for 8, 10 minutes at 40 degrees temperature of Fahrenheit and not shiver at all. In fact, one time I stayed in long because I hadn't shivered. I did get a little hypothermic, so that's how I learned about brown fat and white fat was through ice bath.

Melanie Avalon: Yeah, that's super cool. I remember Scott and I met. When did we meet? Spring of 2021?

Scott Emmens: I think you're right. I think it was April of 2021.

Melanie Avalon: Yeah, because we launched serrapeptase in 2021.

Scott Emmens: November. Yeah.

Melanie Avalon: Yeah, I think that was one of our first conversations way back in the day.

Scott Emmens: First conversation was ice bath and then followed by a lot of discussion on infrared, near-infrared and therapy and saunas, which I'm also a huge fan of, by the way.

Melanie Avalon: Yes, so many things. One last health benefit-related thing I think we should talk about, especially with this show one of the reasons people often do fasting, well, it's not the reason, but something we've talk about a lot with the benefits of fasting is how fasting stimulates something called an AMPK, which is basically a fuel sensing enzyme. It plays a key role in how our bodies use energy and it's activated by stressors like calorie restriction, fasting, and exercise. It is associated with so many health benefits like you want AMPK activation, it helps with longevity, metabolic health, inflammation, so many things. Berberine has found to be a very potent stimulator of AMPK, which is awesome. And then another fasting-related thing we talk all the time on here about autophagy which is activated by fasting as well. And it's where the body actually goes down and breaks down problematic proteins and recycles them. It's like a cleanse on the cellular level. It's very, very important for metabolic health and longevity. And berberine has also been found to be a stimulator of autophagy, so that is awesome.

Scott Emmens: People underestimate the importance of healthy autophagy getting rid of cells or what they might call zombie cells or mitochondria that need to go because they'll contaminate the other healthy mitochondria around it. I think autophagy is a tremendous benefit. And obviously, the AMPK there's a plethora of data on all the various things that impacts across your longevity and health span. One of the things that I don't think we touched on but, I know came up in literature quite a bit, is the positive benefits of berberine on the liver. And I'm a big guy on liver. I think if your liver is not functioning right, if it's not making bile, if it's not digesting your toxins properly, you're going to end up in trouble. And so, to me, I think that the liver benefits of berberine have probably underestimated at this point. There's not as much data and studies as I'd like to see. But there is definitely data to suggest that it works to support liver enzyme health, liver function in the presence of toxins, and I think that is really important. When you look at the overall effect of what berberine is doing to your point earlier, it's working on AMPK, it's working on glucose, it's working on your gut microbiome, it's working on your liver and your liver's function. And I think all of these things combined lead to, in my mind, one conclusion which is, there's something about this particular product that allows your body to function in an optimal level while keeping the blood glucose down, supporting mitochondria, supporting liver health and I think it all ties back to, if blood glucose and insulin are lower, then you're going to have a cascade of positive effects across your body. And I think that is why CGMs have become so popular as people realize that if they can keep their blood glucose at a reasonably modest normal level without having huge spikes throughout the day, that overall is going to lead to a longer and healthier lifespan. The data on that is pretty convincing. That's where I think berberine shines as this molecule plant alkaloid that just has so many benefits. So back to the liver, there is a couple of studies on liver enzymes and also on liver function. I would encourage people to take a look at that research. Again, of course, always speak to your doctor if you're taking anything for liver disease.

Melanie Avalon: I'm so glad you mentioned that as well because that actually goes really well with one other health benefit I want to touch on and it also involves the liver, so glad we're talking about it. And that is the role of berberine on cholesterol levels and lipid panels. Margaret said for example, "Is it okay to take it long term to help lower cholesterol" and we can speak to the long-term aspect in a bit but just as far as the cholesterol side of things. Not only does it directly reduces the absorption of lipids into circulation from your gut, because the whole caveat there is dietary cholesterol is not necessarily the primary driver of problematic cholesterol levels. It's more at least in my opinion, the creation of endogenous cholesterol and what's happening with that. And the effects in the liver on cholesterol and lipids is-- I mean, there's so many so.

It can promote the liver's LDL receptor mRNA expression to beneficially modulate LDL levels, it can directly inhibit the creation of cholesterol and triglycerides in liver cells. In rodent trials it's been found to inhibit NAFLD, nonalcoholic fatty liver disease in mice fed a high-fat diet, which is huge and in human trials have actually found that berberine supplementation can reduce liver enzymes in patients with type 2 diabetes and so going back to what Scott was saying about liver health and it can also reduce fatty acid synthesis directly in the liver and a lot of transcripts and factors related to fatty liver. And for example, there was one study in humans and not only did they find decreased body weight and BMI in those on berberine, but what was super cool about the study is it had people do berberine and then have a washout period where they were not taking the berberine and then go back on the berberine. And they found that their triglycerides, their cholesterol, their LDL, and their HDL all improved based on when they were like taking the berberine. When they were on the berberine, it improved. When they went off, it went away. And then when they went on again, it approved again. Lots of potential benefits there with cholesterol and lipids.

Scott Emmens: Yeah, I totally agree. And the one part I'd like to focus on that is with triglycerides. Having been in the diabetes universe for 15 years or so, one of the things that I spoke with when I worked with endocrinologists, those are the specialists that treat diabetes, the thing that the cutting-edge endocrinologist would tell you is if you see someone that has a relatively high fasting glucose, but they are not diabetic, but their triglycerides are above normal. He's like that person is going to have diabetes if they don't change their lifestyle in a few years. Triglycerides are the leading indicator like "Hey, you're on your way to diabetes if you don't change this." Your body is basically taking this sugar and trying to figure out what it's going to do with it because it can't do something. This isn't the scientific way to say this, but basically, your triglycerides are this canary in the coal mine, that if they're high, but your blood glucose hasn't quite broken, technically the diabetic limit, you're probably on your way there. That's something you really want to look out for [the fact that it does have these studies that show that it can have a positive impact and support the body's ability to reduce triglycerides really says something to me about the way that it's working for blood glucose.

Melanie Avalon: And I think that actually ties in nicely to something that I want to talk about, which is this specific form that we chose because we got a lot of questions about dihydroberberine. for example, Teresa said, "She wants to know the difference between berberine versus dihydroberberine." Erin said, the same thing, "What's the difference between those two?" Suzie said, "What is the difference between them and what is the best?" Paul said that "He actually did better taking dihydroberberine that he didn't have the bloatation and the gassy issues?" And then Amanda said that --Oh, this is something that we can speak to the absorption levels. Amanda said, "Mike Mutzel talks about not using the highly absorbable kind," which presumably, I'm assuming is the dihydroberberine, as that's how berberine is effective in the gut by not being highly absorbable. Just speaking to what you were just talking about Scott with all of these over-encompassing effects and many things that are going on, shall we talk about? Because we debated for a long time about? Well, more so in the beginning, I think once we got to an understanding about it, we felt pretty good. But we were looking at? Should we do a berberine or should we do a dihydroberberine? Dihydroberberine is a newer form of berberine, at least from being like sold and marketed, which is said to be more absorbable and said to have a more potent effect on lowering blood sugar? We chose not to do that. Scott, would you like to explain a little bit why?

Scott Emmens: At first, it was two things. I think this goes back to my experience with prodrugs and metabolites prodrugs and then also looking at the data. Of the 30 years' worth of research that we have a good grasp on and there's a ton in the last 15 years, all of it is on berberine or the vast, vast majority I should say. There is very little data on dihydroberberine beyond just either its increase of "plasma level," but plasma level is not really what separates Berberine from the pack. I'll give you an analogy and tell me if it's apt Melanie. But with CBD, for example, "If you get a pure 100% isolated CBD, you may have no effect from it because it's not just the CBD, it's the CBD, CBG, it's the other cannabinoids inside that product that give it an entourage effect along with terpenes and other things that create that. Then if you add the other factor into metabolites from a prodrug is a drug that goes in as an inactive substance. And then your liver converts it into an active substance. Well, berberine happens to have no less than four active metabolites and as many, in some reports as 17 metabolites. And we don't know what those metabolites do, but it's pretty clear, and here's a direct quote from an article. Let me just make sure I get the title. "This is the metabolism of berberine and its contribution to the pharmacological effects." 

And then let me read this quote because this wasn't something we had focused on a ton in the beginning, but we discussed it, but the more we did the research, the more evident it became that there's something unique about it. "Even though berberine possesses a low oral bioavailability, it has exhibited marked biological activities in vivo which is in people and concentrations of its major metabolites such as berberrubine, thalifendine, I'm going to say these wrong, I'll butcher these names, demethyleneberberine, and jatrorrhizine, that is butcher of those names, but they are relatively high. And then it says, "These reports indicate that the metabolites of berberine may be active constituents which are representative of the biological activities of berberine in vivo and I mean that sums it up that there is something unique about berberine despite this, "Low bioavailability." Study after study shows that it works and then now we're getting more and more studies that are coming in. And our ability to measure these metabolites that are coming in active tablets, meaning your livers convert it into a new active form of berberine. They are actually also stored in your various organs, like your liver, in your kidneys, in your brain and other places that allow for these other properties of berberine or that we suspect based on the data allow for these other properties of berberine. By isolating one particular compound, yes, you may get less side effects, but you may not get all of the benefits of berberine. And I think between that and the fact that the data is very consistent on berberine, says berberine is the way to go. Now, we might decide to do a dihydroberberine in the future for some other specific reason, but if we're looking to get the maximum benefit across the spectrum of berberine, then we wanted to use the whole berberine plant.

Melanie Avalon: I think it's so interesting, Scott found, I don't know if it's the one that you were just speaking about, or if it was a different one. But you found this really great article, which basically speaks to this issue that people will say about berberine, which I find really ironic because people will say it's not very absorbable, like an issue basically, and that we need to fix it. But it's just really ironic, because all of the studies for so long and then it's been used for thousands of years, have been working with it in this form, so clearly, it's working in this form.

Scott Emmens: And then all of the data is in this form. When they saw the studies we read to you today, all of the data we've read to you today is from berberine. And so, you could take a chance that yes because it's more "Absorbable" and less impactful in your gut. Well, okay, maybe that works, maybe that doesn't just because it's higher in your plasma doesn't mean that it's high or concentrated in your organs, which may be the very benefit we're getting. I think you're right, it is ironic that we think we have to fix a product.

Melanie Avalon: It's pretentious.

Scott Emmens: Yeah, we have to fix a product or a natural alkaloid that has decades, in fact, let's go back to your earlier number of 4500 years of use. So yeah, I'm pretty confident berberine is the way to go. And for those folks that do have jabs and again, I would say, take it closer with your meal at first, start low and go slow. So, try one, just take one a day for a while, get your body used to it. You had mentioned maybe it's a detoxification process, go low and start slow. But yeah, I think you're exactly right. To say that this other form is better with no real data, I don't think is the right way to go. Is dihydroberberine, does it have some advantages? It very well could. But when we're talking about all of the data, and all of the studies, and these active metabolites, this is the product that I feel most comfortable taking.

Melanie Avalon: I think that's the key thing to focus on, which I'm not saying at all, that creating an isolated form of anything might have more of a benefit for maybe a certain goal in mind, like you might be able to finesse it to, have a specific intended effect. And maybe with dihydroberberine, maybe people, but again I would just need to see more literature and experience with people. But maybe it does work better for some people, which is great. But what's interesting is often rather than saying-- when people pause at dihydroberberine, for example, often rather than saying, this is another form of berberine that may be more beneficial for certain people for certain goals. It's positive, like berberine isn't very absorbable, they are like discard. They discard the entirety of the berberine literature, which makes no sense. And we do this with other things. We do this with turmeric and curcumin. People will say that we need to take our curcumin supplement because it's not very bioavailable in turmeric, when people have been using turmeric for the benefits for so long, people do it with resveratrol and wine. It's a very common thing that people do.

Scott Emmens: Or like a polyphenol versus an individual phenol. And that's why I love this one specific sentence, which is even though berberine possesses a relatively low oral bioavailability, it has exhibited marked biological activity in vivo. And the concentrations of its metabolites such as I butchered those, indicate the metabolites have an active constituent that represents significant biological activities of berberine. And in fact, berberine studies have revealed metabolites have shown similar bioactivity and it goes on and on. And there is something unique about it, the way that it is absorbed is not directly correlated to plasma. And in fact, it might be within this article or the other one that I had sent you, it says that, "Part of the reason that the plasma levels in berberine aren't high is because it's getting pushed into the organs where it needs to be and that was mind-blowing to me.

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Also related to our whole creation process. We had that question at the beginning about dihydroberberine versus berberine. And then when we decided on berberine, it was time to actually create it and Scott. Shall we tell listeners a little bit about our journey? [chuckles] 

Scott Emmens: Journey is a good way to put it, [chuckles] would you like me to start?

Melanie Avalon: Sure.

Scott Emmens: So, breaking the fourth wall a little bit, Melanie had some very specific criteria, as usual, all legitimate. And we began this pursuit for the perfect berberine. And one of the berberines that we looked at that had this really great story in this great, it's organic from the Himalayan Mountains. And then there was another one from the western part of the country, yada-yada, handpicked, etc. However, when we tested those berberines, they came back with both impurities and their potency level was remarkably low. And then I did a little more research and found that these companies also had some FDA warnings. There's a thing in the FDA when you have a GMP-certified facility, it's not just about the source of where you get the product. The most important thing is, have you done the four critical components of testing, which is strength, identity, purity, and compliance composition? And what we do at MD Logic Health and this is why I think we are so selective about who we partner with in terms of suppliers and also co-branding partners such as Melanie is, we want to be the best of the best, just like Melanie. What we discovered was that these other berberines not only failed to meet the specifications that were required but that also did not meet GMP, meaning the facilities themselves had multiple 43 notices or 402 requirements, which basically means that they were citation with significant issues in terms of their facilities GMP. Some folks, well where's it sourced from?

Well, that's important except the most important thing is have you done the correct analysis to protect yourself against heavy metals, purity, identity, strength, toxins, etc. And when we get a product, in this case, berberine, we quarantine everything that comes into our facility. It has been tested before it is allowed to come in for those four things back to what is the identity? What is the strength? Or the amount of active ingredients? What is purity? Meaning, are there toxic metals? Does it meet all of the standards that we're referring to? And is it meeting all of the compliant FDA requirements for purity, potency, etc. Those four things are done before that product even comes into our doors. Unfortunately, two of those products failed to meet our standards, which obviously disappointed us, but we were not going to allow faulty product or subpar product into the process. And when I went to look back at the companies that were utilizing these products, what I discovered is they had multiple 43s including but not limited to various toxins, lack of doing the standard studies, and in shocking fashion rat feces in a number of their herbs.

Melanie Avalon: Was it in the herbs or in the facility?

Scott Emmens: It was in the facility. I don't know whether it was in the herb or whether it was contaminated in the facility, or how but it was tested and found in the facility, meaning that multiple of their herbs had rat feces in them. And this is a pretty well-known brand, which we're not going to mention. But the fact of the matter is that they had obviously either not quarantined it and brought it in with the feces or the feces was in the facility and they hadn't done their due diligence on making sure that the facility was properly protected against those types of things. When a company says they're GMP certified that's one thing. But they need to be following all of those GMP tests. The reason that we quarantine the product before we bring it in, is if that product is contaminated you run the risk of contaminating your entire line. That's why it is quarantined and tested prior to its entry into our facility. 

Once it's tested and it passes all of those tests, we then bring it into the facility and then we do again, what's called batch testing. And we retest that same product after it's been manufactured to make sure it still meets all those specifications and has the amount of milligrams we'd say it has, it has the proper ingredients, and it still meets all of the same parameters to make sure that it didn't get infected or contaminated along the way. it's not just important to do it after you've created it, it's important to do it before it enters the facility. It's important to make sure you follow all of the criteria that GMP lays out in terms of where you store your product, how high you store it, what temperature you store it at, all of these things add up to what's called good manufacturing process. It's more than just testing for purity, strength, identity, and compliance. It's also, "Did you do the proper testing on how long it's going to last on the shelf, for example? What temperature did you expose it to? Did you have a CoA from the supplier of the ingredient and then did you also subsequently test it?" Some people will take the CoA from the supplier as the gold standard and then not do their own testing. That's not the way to go, because they may have gotten one sample to pass that test. But they can give you a different version or a different sample or a different supplier. And sometimes companies will change suppliers without then doing a retest of the ingredient. And then of course is not kosher either. You've got to make sure that you're doing GMP, the way GMP is written. And that is why there's a difference between us and folks that aren't following those same procedures.

Melanie Avalon: Yeah, so I actually just pulled up the warning letter that you had found about that company because I wanted to see exactly what it had said. And this wasn't for their actual berberine, it was for the company in general but their manufacturing plant basically. And for example, this is direct from the FDA warning letter. It says, "Tree nut shells, peanut shell, corn, rodent feces, and seed foreign material were detected in their ashwagandha." "Tree nut shells, glass, hard plastic, and rodent feces were detected in their bilberry fruit." And there are a lot of other things as well. Scott, this is so shocking, so like ashwagandha that they're talking about, they had rodent feces in it as well as all of these allergens. If you go to their Amazon page, there ashwagandha has 506 ratings, 4.5 stars, it says that it's organic, it says it's free from gluten, dairy, and soy. The other pieces in this warning letter say that they found wheat in some of their other-- "Wait, wait, wait, sorry, I missed that." Wheat and rock were also found in their ashwagandha. So, "Ah", listeners, literally, so like you can go to Amazon and get this ashwagandha 506 ratings, 4.5 stars, it says "It's organic," it says "It's gluten, dairy and soy free." And when they tested this, when the FDA tested this, they found gluten, rat feces, and a myriad of other things. This is just so problematic. This is so problematic.

Scott Emmens: It is. I want to make the statement that I think this is the more rare companies, but it does happen, it does exist that you can have a GMP facility with great ratings and a decent brand name and still have-- I mean, I think those are pretty significant issues.

Melanie Avalon: And this isn't like some small-- like they have a lot of reviews on Amazon and a lot of products.

Scott Emmens: Correct? So, bigger doesn't mean better. What means better is, "Did you follow GMP and what is your track record with the FDA?" And we have an immaculate track record. And I think that speaks volumes. But the reason we have it is we just believe in following the procedure to make sure that like our families take our products, I take AvalonX products, I take MD Logic products, I give my family MD Logic products, I would never want to have skipped a process or a step. Because those processes are put in place for very good reasons. And most people aren't aware of those because they're not readily public-- it's not readily public information. But I think I remember I got a five shock emoji face from you when I sent you that link.

Melanie Avalon: Listeners, friends, do your due diligence when you choose the supplements that you choose to put in your body. We found a source that we felt really good about with the testing and we tested it for purity and potency. But then we wanted to go one step further because this was my first supplement that was an herb. My previous supplements have been serrapeptase and magnesium. We had the certification from the source that it was free of pesticides. But it was really, really important to me that we do third-party testing on that, just like we did the third-party testing for the purity and the potency because again it's an herb, it's being grown. That took a while because it took a while to find, what was the word like a company that would do the test?

Scott Emmens: It was a third-party laboratory that would do pesticide testing as well as other testing. But we chose at that point, we had all the other testing, we had done internal heavy metal testing twice, internal purity, internal identification and compliance, so at that point we really just wanted to make sure is this was pesticide-free by all the definitions that are set by the US Government and then some. And we set that out for a third-party pesticide test.

Melanie Avalon: Yes, and I'm so happy we found a company that we really like to do that and it came back all clean, all good. And I should tell them the nuance of it. Another reason it took so long to find a company is most of the companies would just give you a blanket, like a yes/no about whether or not it was below a certain level. But I wanted it to be quantified. [chuckles] I wanted to know if it was there, like how much was it there? It took a while to find a company that could work with us to do that, but we did. And we got the green light, it's all good, no pesticides.

Scott Emmens: It really is. And I'll tell you, I would not take any other berberine than this one based on the fact that we know the source is good. We've triple-tested it in-house for the four cores, which is purity, heavy metals, etc., identity, purity, strength, and potency. So, at this point, we feel like we've got a great berberine that's pesticide free, heavy metal free, toxin free, mold free at the right dosage, and in a glass bottle and on top of that with no stearates, palmitates, or other heavy chemical anticaking or filling agents. It's the purest best berberine I think that you're going to find in terms of literal testing and its final ingredients.

Melanie Avalon: I always have to ask you Scott, its filler and lubrication agent?

Scott Emmens: Yes. there are two things that people should be familiar with it. There's what they call lubrication or anticaking. Because when you put these products through these machines to put them in little tiny capsules, it requires some lubrication agent. And that's typically a magnesium stearate, silicon dioxide, or they'll call it silicon, which is silicon dioxide because that FDA allows you to say silicon versus silicon dioxide, little euphemism or a calcium palmitate. I'm okay, I take products with magnesium stearate. I don't think it's the end of the world. But if you're taking 15 capsules a day, you want to get it as pure as possible. And I think in this day and age, we're already exposed to so many things, we want to make sure that it's as clean as it can be. So yes, this product is free of magnesium stearates, that is an anti-caking agent which means it prevents it from blocking up the machines, which is also why we have to do small batches and why it's a little pricier because in order to shut down an entire line or have a dedicated line that has no lubricant or non-magnesium stearate/palmitate lubricant, you've got to have these smaller batches or a dedicated machine. And that's anti-caking. They're called lubricants and then there're fillers which are typically rice or cellulose or something else that you may or may not want. So typically, when we do a filler and we only do that when we have to whether that's an AvalonX product or MD Logic product, we use most benign possible filler there is which is methylcellulose, organic grown, human use, basically methylcellulose, which is like tree bark or fiber. And the only reason you do it is that the capsule doesn't shake loose. In other words, if the capsule size is-- you've got to get the capsule full, otherwise it's going to shake loose and the capsule doesn't feel right or fit right.

The anti-caking agents prevent the product from blocking up the machine, clogging up the machine, and keeping the product flowing into the capsules properly. But a lot of folks don't want magnesium stearate, hence why we go the extra mile to do two things which is A, use either no anti-caking or a natural anti-caking agent that is either beneficial for you or neutral or none. And then on the filler, we use either no filler or we use a filler that is methylcellulose or something super benign or beneficial rather than things like rice flour or other things that people can be allergic to.

Melanie Avalon: Yeah, so the berberine containing a very small amount of monolaurin, which is exciting because people will actually take monolaurin for its health benefits. But I don't like to emphasize it because it's not like-- it's barely in there. But yeah, so it's nice to have something that could be potentially beneficial in there as well.

Scott Emmens: And the monolaurin, in this case, would be the anti-caking agent. But to your point, some people take monolaurin as an actual supplement for health, for digestive health. And I think it pairs really well with berberine as I take it for digestive health in terms of its benefits.

Melanie Avalon: Yes. But I really want to emphasize, it's not like monolaurin is in there as a supplement like you're barely getting it. It's more just to point out that it's benign, like it's nontoxic.

Scott Emmens: Exactly, you're talking about a minuscule amount of monolaurin, so it's [unintelligible [01:28:27] supplementation of it. It's really just because this is either beneficial or neutral versus some people who feel that the stearates can be negative.

Melanie Avalon: Exactly, so yeah, I'm so excited because it's almost here. No, no, no, no when this releases it will have just launched. So friends, if you want to get this berberine we are having an amazing launch special that is through the holidays, through December 31 right like through the--

Scott Emmens: Correct, it starts on December 16 and goes all the way through the holidays through December 31. Perfect time for your January 1st New Year's resolutions and there's a tremendous discount that Melanie will have on her website. So, Melanie, I'll let you take it from there.

Melanie Avalon: During this launch special, you can get 15% off of one bottle or 25% which is amazing, off of two or more bottles. And that is just during the special and/or while supplies last. Stock up now. That we'll be at avalonx.us. Again, avalonx.us, 15% off of one bottle, 25% off of two or more bottles through the end of 2022. Beyond that, some other resources, if you want to stock up or get my other supplements, serrapeptase and magnesium, you can use the coupon code MELANIEAVALON that will get you 10% off or if you would like 20% off code, you can text AVALONX, just the word AVALONX, you will not believe how many people text, not AVALONX. They text like, they're like, "Hi, give me the 20% off code?" Like no, no, no that's not how this works, the computer can only read AVALONX.

Scott Emmens: It's a computer. Yes.

Melanie Avalon: It's a computer. So, text AVALONX To 877-861-8318 that will sign you up for text updates and will give you a 20% off code. You can also get email updates at avalonx.us/emaillist. And then both that 20% off code and the 10% off code MELANIEAVALON are also good at MD Logic Health, Scott's main company, they have an array of-- how many products do you have, Scott?

Scott Emmens: Right now, we have about 40-something skews and products. And we are probably going to have somewhere closer to 65 mid 2023, we got a very aggressive pipeline of either cutting-edge and/or newly formed versions of products that we feel like it would be beneficial.

Melanie Avalon: Yes, so that's super, super exciting. So, definitely check them out. I know one of the supplements we've talked about a lot on this show is your melatonin. I know people are really liking that one.

Scott Emmens: Fanfare for sure.

Melanie Avalon: Yeah, as well as Scott's collagen.

Scott Emmens: Thanks for mentioning both. The melatonin we reformulated by the way which is the exact same melatonin formulation, but we took out the rice and we took out-- I think it had a little mag stearate, so we removed that. So now that is an even more pure, more clean version of our Melatonin Max. And yes, our Marine Collagen is doing really well. People love it because you are getting 13 g of collagen plus you are getting what they call co-factors to create collagen or collagen synthesis in your body. People underestimate that part because you can take as much collagen as you want without vitamin C, manganese, zinc, vitamin A, and vitamin C. You cannot convert those amino acids into collagens. So, you can drink collagen all day, sort of making a cake with a ton of powder, but if you don’t use a little bit of sugar and butter, you are just going to have a giant flour cake.

Melanie Avalon: Yes, so I can guarantee you this collagen was Scott's baby, kind of like the way I am with my supplements. If you are looking for collagen supplement. This is the one that you want for sure. If you want to go through my site to get that, the link is melanieavalon.com/mdlogic and again the coupon code MELANIEAVALON will get you 10% off sitewide. As well as that 20% off coupon code that you by texting AVALONX To 877-861-8318. And again, stock up on berberine before the special ends.

Scott Emmens: Well Melanie, I've never been so excited for one of your launches as I am for berberine. I feel like your audience is going to love this. I feel like this is going to be a tremendous product for your fan base but most importantly, I think now having done three products with you and having had multiple discussions on your future products I feel like I need to assure your fans that you do not let a single thing go. Every single thing that goes into this product and does not go into this product. You have your eyes on, the research on, and I think together we are making a fantastic team and even more importantly great products that are really healthy and great for people and I couldn’t be more thrilled to launch berberine with you, so this is fantastic.

Melanie Avalon: I am just so thrilled and honored and excited and grateful as well. Listeners, working with Scott has been the dream partnership and I am just so grateful that I can finally do exactly what I wanted to do with the supplements and make them for myself and for everybody else, so I am so happy. Actually, this is a good way to end literally just right now Scott, you know how you were mentioning earlier the person at the CGM company who was sharing his experience on the podcast. He actually literally just emailed me because I had emailed him to tell him I was making a berberine. Would you like to hear what he said about berberine?

Scott Emmens: I would love to hear what he said. This is like serendipity.

Melanie Avalon: I know this is like in real life like real-time. [chuckles]

Scott Emmens: It's real-time and it's happening at the moment.

Melanie Avalon: Complete third party. All I did was I told him I was making a berberine supplement. So, he said, "Berberine is a great idea of all the supplements I've tested for glucose regulation, berberine has had the most significant impact and our internal staff experiments confirmed my anecdotal observations." One cool thing to test with berberine would be proper dosing. Most use berberine as a pre-prandial taking 500 to 1000 mg 20 minutes before meals. I tried that and it didn’t work for me." That's what he was saying, Scott. "A smaller camp including myself takes 500 mg twice daily morning and evening. While it did take a few weeks to see results, I saw an overall decrease in my own fasting glucose on that regimen." So that's a nice little testimonial and I think it really speaks to when you guys get your berberine you are going to need to find the way it works for you specifically.

Scott Emmens: That is a great way to end. I think that's serendipity.

Melanie Avalon: I think so. Well, this has been absolutely amazing and Scott you are going to have to come back for all of our future product launches. I hope you are down with that.

Scott Emmens: I can't wait. I look forward to any questions, comments from the fans. I'm starting to feel like a fan and a welcome member of the family of the IF Podcast. So, thank you so much for having me again, Melanie, I look forward to us speaking again.

Melanie Avalon: You too and this will have already happened, but have a Happy Thanksgiving.

Scott Emmens: That's right, you too.

Melanie Avalon: Bye.

Scott Emmens: Bye, bye.

Melanie Avalon: Thank you so much for listening to The Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Dec 11

Episode 295: Food Choices, Macros, Ketosis, Chronic Pain, Oxalates, Organ Meat, Variety In Fasting, Exercise, And More!

Intermittent Fasting


Welcome to Episode 295 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

BUTCHERBOX: Grass-Fed Beef, Organic Chicken, Heritage Pork, Wild-Caught Seafood: Nutrient-Rich, Raised Sustainably The Way Nature Intended, And Shipped Straight To Your Door! For A Limited Time Go To Butcherbox.com/ifpodcast And Get Free Ground Beef For LIFE Plus $20 off your first box!!

BEAUTY AND THE BROTH: Support Your Health With Delicious USDA Organic Beauty & The Broth Bone Broth! It's Shelf Stable With No Preservatives, And No Salt Added. Choose Grass Fed, Grass Finished Beef, Or Free Range, Antibiotic And Hormone-Free Chicken, or Their NEW Organic Vegan Mushroom Broth Concentrate! The Concentrated Packets Are 8x Stronger Than Any Cup Of Broth: Simply Reconstitute With 8 Ounces Of Hot Water. They’re Convenient To Take Anywhere On The Go, Especially Travel! Go To melanieavalon.com/broth To Get 15% Off Any Order With The Code MelanieAvalon!

FEALS: Feals makes CBD oil which satisfies ALL of Melanie's stringent criteria: it's premium, full spectrum, organic, tested, pure CBD in MCT oil! It's delivered directly to your doorstep. CBD supports the body's natural cannabinoid system, and can address an array of issues, from sleep to stress to chronic pain, and more! Go To feals.com/ifpodcast To Become A Member And Get 50% Off Your First Order, With Free Shipping!

To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get Free Ground Beef For LIFE Plus $20 Off Your First Box!!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz

Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

Go To cynthiathurlow.com/creatine and use code CYNTHIA for 10% off!

Episode 292: Creatine, Brain Health, Sex Hormones, Muscle Building, Insulin Sensitivity, Sarcopenia, Andropause, Mood, Motivation, BDNF, And More!

BEAUTY AND THE BROTH: Go To melanieavalon.com/broth To Get 15% Off Any Order With The Code MelanieAvalon!

Listener Q&A: Heather - IF

Listener Q&A: Robyn - Chronic Pain Flair

The Melanie Avalon Biohacking Podcast Episode #104 - Sally Norton (Oxalates)

The Melanie Avalon Biohacking Podcast Episode #153 - Bill Schindler

Ep. 238 Eat Like A Human: What Should We Eat? with Dr. Bill Schindler

Go to eatpluck.com an use the code CYNTHIA15 for 15% off!

FOOD SENSE GUIDEGet Melanie's App To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More!

Go to safecatch.com and use the coupon code for MELANIEAVALON for 20% off!

The Science, Nutrition, And Health Implications Of Conventional Vs. Sustainable, Grass-fed, Pastured, And Wild Meat And Seafood, Featuring My Honest Butcher Box Review!

FEALS: Go To feals.com/ifpodcast To Become A Member And Get 50% Off Your First Order, With Free Shipping!

Listener Q&A: Therese - Repetitive Routines Or Mix It Up?

Listener Q&A: James - Constantly Changing Fasting Windows

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 295 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time and get ready for The Intermittent Fasting Podcast.

Hi friends, I'm about to tell you how you can get free grass-fed, grass-finished beef for life plus $20 off, yes free grass-fed grass-finished ground beef for life plus $20 off. We are so, so honored to be sponsored by ButcherBox. They make it so, so easy to get high-quality humanely raised meat that you can trust. They deliver 100% grass-fed, grass-finished beef, free-range organic chicken, heritage-breed pork, that's really hard to find, by the way, and wild-caught sustainable and responsible seafood shipped directly to your door. When you become a member, you're joining a community focused on doing what's better for everyone. That includes caring about the lives of animals, the livelihoods of farmers, treating our planet with respect, and enjoying deliciously better meals together. There is a lot of confusion out there when it comes to transparency regarding raising practices, what is actually in our food, how animals are being treated. I did so much research on ButcherBox. You can actually check out my blog post all about it at melanieavalon.com/butcherbox. But I am so grateful for all of the information that I learned about their company. All of their beef is 100% grass-fed and grass-finished that's really hard to find and they work personally with all the farmers to truly support the regenerative agriculture system. I also did an interview with Robb Wolf on my show, The Melanie Avalon Biohacking Podcast, all about the massive importance of supporting regenerative agriculture for the sustainability of not only ourselves but the planet. This is so important to me. I'll put a link to that in the show notes. 

If you recently saw a documentary on Netflix called Seaspiracy, you might be a little bit nervous about eating seafood. Now, I understand why ButcherBox makes it so, so clear and important about how they work with the seafood industry. Everything is checked for transparency, for quality, and for sustainable raising practices you want their seafood. The value is incredible, the average cost is actually less than $6 per meal, and it's so easy. Everything ships directly to your door. I am a huge steak lover. Every time I go to restaurant, I usually order steak. Oh, my goodness, the ButcherBox steaks are amazing. I remember the first time I had one and I just thought, “This is honestly one of the best steaks I've ever had in my entire life.” On top of that, did you know that the fatty acid profile of grass-fed, grass-finished steaks is much healthier for you than conventional steaks? And their bacon, for example, is from pastured pork, and sugar and nitrate free. How hard is that to find? And ButcherBox has an incredible deal for our audience. For limited time, you can get free grass-fed grass-finished ground beef for life in every box of your subscription plus $20 off, yes, new members can get free grass-fed grass-finished ground beef for life plus $20 off when you go to butcherbox.com/ifpodcast, that's butcherbox.com/ifpodcast for free grass-fed grass-finished ground beef for life plus $20 off and we'll put all this information in the show notes.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. And then in our bodies, studies have shown they do things, like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years.

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means, when you put on some conventional lipstick, 30 years later, maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so, you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list, so definitely check it out. You can join me in my Facebook group Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you're thinking of making Clean Beauty and Safe Skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now back to the show.

Hi everybody and welcome. This is episode number 295 of The Intermittent Fasting Podcast. I'm Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, Melanie, how are you?

Melanie Avalon: I'm okay as you know. I honestly forgot what this is like to be super sleep deprived because I put a lot of effort into making sure that I get a lot of sleep, like I prioritize it like none other. So right now, I'm currently in the virtual queue for the Taylor Swift Presale Concert. And it's been five hours and I'm like not present. And I was texting Cynthia being like, I don't know if I'm going to be able to record but we are here. But I forgot what this feels like, I took some coffee.

Cynthia Thurlow: Good. So, a stimulant will definitely help you, but you're like a real person.

Melanie Avalon: I know. But I feel like I'm not quite present.

Cynthia Thurlow: Yes, but it's amazing how when you have like one blip in your sleep radar, you actually you'll be fine. You'll be tired, you'll go to bed probably around your normal time and then tomorrow you'll wake up and feel totally normal.

Melanie Avalon: So true, I don't normally-- I think we've talked about this. How much coffee do you drink? 

Cynthia Thurlow: Zero.

Melanie Avalon: Oh, none.

Cynthia Thurlow: Yeah, I'm not a coffee drinker. And it's funny because I had some genetic testing done and they actually said I do fine with, caffeine but I have to be completely transparent and say I made it through all my pre-med classes, all of undergrad and grad school never drinking coffee.

Melanie Avalon: With no coffee?

Cynthia Thurlow: No coffee. And the nights, I worked nights in ERs and worked overnights in the hospital and no coffee. I would drink, I can't limit this. I used to drink Diet Pepsi, which is disgusting.

Melanie Avalon: So, you weren't getting caffeine?

Cynthia Thurlow: But I couldn't tolerate it, it's not something I could drink every day. It was like, I would bring it with me in case I felt like I literally could not keep my eyes open but not every day. So, I'm officially very much an early bird that is uncaffeinated, except for my occasional green tea, which I don't necessarily have every day out of laziness.

Melanie Avalon: I was thinking about it actually a few days ago. Because normally I think I've shared this before I literally just have like a sip of coffee, like a sip every morning. It's more just a mental thing. It's probably like no caffeine in it at all. But I was reflecting their day on how nice it kind of is to not be dependent on coffee because I know and I mean I would go through, like in college really intense periods and coffee is something were-- like I did my experiment with alcohol and wine where I didn't drink for a year to see if I was like happier not drinking and I realized I was much happier having wine every night. Like with coffee, I feel like if I go into a coffee every day, I think I am happier without coffee, because it's just nice not to have to use it. And then when you need it, like right now, it's like very potent, and I probably just had like, a quarter of a cup and I'm like, okay.

Cynthia Thurlow: [laughs] But I think it's also recognizing that this is like a good indication of a day that you do well with it. Like, I will take adaptogenic herbs or I will take glandular products if I feel like I definitely need a little bit of support. But I don't, I like the way coffee smells. I just don't like the way it tastes, I never have and it's ironic that I have a child that's kind of an espresso Americano snob and really is into his coffee and then the other three of us don't drink it at all.

Melanie Avalon: Oh, wow. Yeah. I will say though my thoughts on coffee just in case people are curious because I'm not trying to scare people away from coffee. I feel like the studies are pretty consistent that coffee drinkers have health benefits.

Cynthia Thurlow: Well absolutely, the polyphenols and the plant-based compounds in coffee and bitter teas are, it's undeniable. I think that's how I actually started forcing myself to drink green tea a couple of days a week with a understanding that those bitter plant-based compounds actually have physiologic benefits. And so, I'm like, "Okay, you're going to learn how to drink this?" And so, I iced my green tea. That's how I drink it.

Melanie Avalon: It's also pretty mind blowing. I'm pretty sure they say isn't coffee our biggest source of magnesium? Am I making that up?

Cynthia Thurlow: I mean I think about getting a lot of those from brightly pigmented vegetables. And I think coffee is very bio-individual because I have some patients that will actually increase their cortisol, which increases their blood sugar. And so, it's figuring out what the right amount is for everyone. I used to have patients that would drink, I don't know, 10 cups of coffee a day. And I was like, how are you functioning? I would be a like nervous, jittery, mess.

Melanie Avalon: Yeah, I mean there's definitely that tolerance that happens. I shudder thinking about how much I drank in college. I don't know why I was thinking coffee was this high source of magnesium. But I think it is definitely like the number one source of something like polyphenols or something in Americans' diets, which is interesting.

Cynthia Thurlow: That is, I would hope it would come from a combination of things and not just something drinkable. But I think Americans just really, like I understand, I love the idea of something warm and my hands like the ritual of that I get, but I don't know, I like getting polyphenols from a variety of things, even bitter herbs and vegetables and things like that.

Melanie Avalon: I looked it up, it is antioxidants for most people. That's crazy.

Cynthia Thurlow: Well, think about how many people are drinking regular coffee as opposed to like understanding that it tends to be a mycotoxin-rich food product and just understanding that there're some nuances to the healthiest options that are out there. I'm probably going to get hate mail from the coffee lovers out there. But that's always the way I think about it. As I think if you tolerate coffee and you enjoy it, that's great. Just try to pick the best quality product that your budget permits.

Melanie Avalon: Yeah, I definitely think like you mentioned those mycotoxins are quite an issue. And then just one other comment about what you're mentioning about the sleep. I'm prepping right now to interview, Heather Moday, she wrote a book about the Immune System and Immunotypes, I think I mentioned it on a previous episode. And something that just stuck with me that she was talking about was sleep and she was saying how like out of all the lifestyle factors like diet, sleep, exercise, sleep is hands down the thing that can give you the fastest return on investment, but basically what you were just saying like with one night's sleep, you can see so many changes and improvements in so many biomarkers, compared to like diet where you have to like takes a little bit and exercise even so, yes, value your sleep is the point. So, anything new with you?

Cynthia Thurlow: Oh goodness, we are finalizing our plans for spring break. So that's been exciting. And every year I plan a spring break trip and no one knows what I've planned. And so, there were some requests at the end of last year they didn't want to go away for Christmas. I was like, "Okay, I got that." And so, we're doing something different. We are flying to Portugal and we'll be in two cities there and doing a variety of historical things and food tours and I'm excited.

Melanie Avalon: Awesome and how are things going with your creatine?

Cynthia Thurlow: Good, it's really exciting, we've got amazing feedback. And from my perspective, women having a better understanding of how it can improve both cognition and muscle health. And it was interesting, I was presenting a research article to some of my coaches today and I was telling them about the role of lowered levels of estrogen, how that impacts muscle protein synthesis, and why in those instances, it's even more important that we're taking exogenous, meaning creatine outside the body because our body-- women actually make 70% to 80% less creatine endogenously, inside the body, this gets exacerbated further heading into perimenopause and menopause. So, I was talking to them about how they were looking at two different groups in this randomized control trial. Women that were taking creatine and not doing any strength training versus women that were taking creatine and doing strength training. And there was no comparison in terms of the net improvement in muscle quality and muscle health. I think on a lot of different levels, what I've been loving is just having the conversation about the unique needs of women. And also identifying that men benefit from taking creatine as well. So, it's going really well, I'm very excited. I'm so appreciative that you encouraged me to create my own supplements.

Melanie Avalon: I'm so excited, I'm really excited as well to hear people's feedback after trying yours. And I just got my notification email that yours is coming, I can't wait to try it. So, I know I've asked you this a lot, "How do I take it, can I take it with food?"

Cynthia Thurlow: You can take it. Typically, what I've been doing is using it in a smoothie, but you can take it with food, you definitely don't want to take it in a fasted state. It's for one of those feeding windows in terms of getting the maximize benefits, but it's a white powder, it's easy to measure, that gives you a complete-- the scoop is for 3 grams. All the research has been done on 3 to 5 grams, 5 grams is I'd be leaning more into individuals that are vegetarian or vegan because their needs are actually increased by virtue of the fact they are not consuming animal-based protein. So yeah, it's super easy to take. It doesn't taste like anything, it blends really easily, thankfully, because I think we've all had powders that are chalky, and don't mix well with water and that's never a good thing.

Melanie Avalon: So, you said it doesn't taste like anything.

Cynthia Thurlow: Mm-hmm.

Melanie Avalon: Really like, nothing?

Cynthia Thurlow: Not to me. I've got this acute sense of taste, I think, which is why I don't like coffee, because it's just too-- I was one of those weird people, anything that I would say I would be like the taste tester a couple 100 years ago to determine if something was poisonous, because I have this crazy acute sense of taste and smell, which is not to my benefit having worked in healthcare for many years.

Melanie Avalon: Wow, oh, I can imagine. I'll probably take it like literally with my food. I'm super weird. I like to take supplements with food like I just eat them. And that's okay, like open capsules and like pour them on things. And like I would order quercetin powder and just like add to my food, I would order all these random things like milk thistle.

Cynthia Thurlow: Oh, you're very adventurous.

Melanie Avalon:  Well, very exciting, so how can people order?

Cynthia Thurlow: Yeah, so you would go to my website and the correct address should be-- www.cynthiathurlow.com/creatine is what it should be. There are all sorts of technological glitches that occur throughout this launch process, it's eliminated, little glitches that we don't think are a big deal and then you realize with coding, any little miss stroke of a key can make things not work properly.

Melanie Avalon: I know it's crazy. I remember when I launched serrapeptase the night before-- the day of because it was a midnight launch. We realized there was a glitch and they had to rebuild my entire website right up until, it was so stressful. Yeah, technology-- and I'm like right now I'm still in this Taylor Swift queue. I'm like staring at the thing. [laughs] 

Cynthia Thurlow: I'm really impressed with your dedication.

Melanie Avalon: I have got to get these tickets. The thing is when they come out, if you know about, you probably don't-- about this verified fan presale that Ticketmaster does?

Cynthia Thurlow: I do not.

Melanie Avalon: So, I learned about it with this, for the different artists they try to make it so that the fans can get tickets without it going through all of these resellers where they jack up the prices so they do this like a special sale where you have to be on their email list and then you have to apply and then you have to be accepted and it seems very arbitrary how they accept you or not. Like my good friend did not get accepted, but I did. So, then if you get accepted, then the day of which was this morning you get in the waitlist, and then you have a code for once you get in to like actually get the seats. But it's been so glitchy I think. Ticketmaster sort of crashed from all the Taylor Swift Fans. So, that's where I am waiting. But okay, sorry, tangents.

Cynthia Thurlow: No, that's super exciting. I'm excited for you.

Melanie Avalon: Last question about the creatine, is there a launch special or coupon code for people?

Cynthia Thurlow: It should be CYNTHIA, it we'll give you 10% off. During the launch we had even more amazing discounts, but now that it is officially on sale, you get 10% off with code CYNTHIA.

Melanie Avalon: Awesome, awesome, awesome. And last question about it. How is your creatine different from other creatines on the market?

Cynthia Thurlow: Well, I think we really did an incredibly conscientious effort to keep it simple, there were lots of ideas that were proposed. And I really wanted it to be creatine monohydrate and without any fillers, to know where it was properly sourced from. And I just think when you get online, and you buy things from Amazon as an example, obviously, there are great things that come from Amazon. But I think when it comes to supplementation, we just have to be careful. And so, we know where this product was sourced from, we know where it's packaged, we know what it's not full of. And I know much to your point about not having fillers and gluten and dairy and soy and other garbagy things that get added to supplements in an effort to keep costs low. This is what I believe to be the most high-quality creatine monohydrate that's available in the market.

Melanie Avalon: Awesome. Well, I can definitely attest to all of that just for listeners who are not familiar, both Cynthia and I work with MD Logic to create our supplements. And the amazing thing about it is the ability for us to really make exactly what we want to make to the highest quality and they test multiple times for heavy metals and toxins and fillers, and it's nice to feel very confident in the products that we're creating. So, I'm very excited for you and the creatine.

Cynthia Thurlow: Thank you. Likewise.

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Melanie Avalon: Shall we jump into some questions for today?

Cynthia Thurlow: Absolutely.

Melanie Avalon: To start things off, we have a question from Heather, the subject is "IF." Heather says, "Can you tell us, ladies, what a day of eating looks like for each of you? How much protein and carbs y'all eat and still are able to maintain ketosis? I'm about to receive all three books from both of you in the mail." This question is from actually a few years ago, she's probably talking about my book and then when Gin had two books. "I'm about to receive all three books from both of you in the mail, so, excited. I have been on keto way of eating for over a year and just starting to look into expanding my carb intake XOXO."

Cynthia Thurlow: Well, Heather, thank you for your question. I would say when I was first new to fasting, I didn't track my macros per se. But obviously, Dr. Gabrielle Lyon's work has had a huge influence on me. And so initially, after I met her, I started tracking protein and that's my guide. Now, I don't track macros because I generally don't need to and I just lean into more of an intuitive eating approach. As an example today, I didn't break my fast until gosh, almost 12:30, because I had to drive to DC with my husband for a doctor's appointment. And so, I sat down and had a bison burger, I had three deviled eggs, I had some sauteed mushrooms, a lot of this is just leftover stuff. And I would say that this is a lower-carb meal for me. I tend to hover under 75 grams, under 50 grams, sometimes as much as 100, but I definitely am conscientious and it's not that I don't enjoy carbohydrates. But even the non-starchy variety just depends on the day. And for me, it was eating a meal quickly because I had things I had to do this afternoon. And then my second meal today will probably be, I think we're going to boil some salmon. And I might have salad, we do a lot of food prep in my house just to make meals move along faster. Today is going to be a lower carb day. A higher carb day, I might have 100 to 125 grams of carbs. I just do better, me personally, when I keep my carb threshold about under 75, under 50 a day, but it's never to be restrictive. It's just I lean into what my body needs. Like yesterday, I needed some more carbohydrates, so I had some blueberries as dessert last night and some dark chocolate. But I think for each one of us, it's really determining what makes us feel good, and I definitely carb cycle. On a day when I have more carbohydrates, I may have three meals in my feeding window, open up my feeding window, and just have more discretionary carbs that might be sweet potato or root vegetables. But the protein piece for me is almost always at least 100 to 125 grams of protein a day. And that's really what I lean into. And then the fats as I need to like today I had olives, which I know that Melanie hates. But I love olives, they're like one of my favorite things. What about you, Melanie?

Melanie Avalon: Yes, so I actually really like this question for a few reasons. One, because people ask me a lot what I eat and I don't like to hardcore share because I'm so crazy. And also, I don't want people to eat what I'm eating because it's what I'm eating. But in any case, to answer this, I don't count protein or carbs, I sort of exist within a macronutrient paradigm. So basically, I just do either low fat, high carb, or low carb, higher fat, not really high fat, I don't ever really go like super crazy on the fat. But in general, I'm usually doing a low-fat, high-carb, high-protein approach. And I'm happy that she asked about still being able to maintain ketosis because I'm going to comment on that. I do the one meal a day for four hours or so every night and it is about a couple of pounds of meat and it's a couple of pounds of fruit. And I just looked up the fruit, I probably eat about 200 grams of carbs and fruit, which is a lot mostly from like blueberries. I used to do pineapple. But the thing I wanted to comment on is maintaining ketosis. I actually don't know if I'm going into ketosis during the fast or how deeply I am If so, I haven't measured ketones and forever. Like last time I was measuring ketones was probably back in like 2018. And interesting, I mean this isn't surprising, but I did find that when I was on the higher fat days especially if I added MCT oil, the ketones would go through the roof compared to not so much on the high carb. But what I want to point out is, you don't have to be in ketosis to burn fat. And I think a lot of people can get all the benefits of intermittent fasting without worrying so much about whether or not they're in ketosis during the fast. So yeah, I honestly don't even know if I'm getting into ketosis, but I am eating about probably 200 carbs every night. And who knows how many grams of protein, whatever is in a couple of pounds of meat?

Cynthia Thurlow: Well, I think the big thing is understanding we're all bio individuals. So, asking us is certainly a great question but by the same token understanding depending on how metabolically flexible you are, depending on your age, how much muscle mass you have, can really influence what your carbohydrate threshold is. And certainly, you don't want to be in ketosis 24/7. In fact, that's why I kicked myself out. That's why I actually alternate the amount of carbohydrates that I consume. And I know Ben Azadi and I talk about this quite a bit. If you don't know, Ben Azadi. He's amazing, a friend of mine who heads up the podcast Keto Kamp and has proliferative content around ketosis and ketones and things like this. And so, we want to vary what we're doing day to day and I think that's certainly important.

Melanie Avalon: Like because of this question, I said, at the beginning, I get so nervous about people thinking there's one answer that they have to do what another person is doing when bio-individuality is so key. I'm actually recording with Ben tomorrow.

Cynthia Thurlow: Oh, good, I love Ben.

Melanie Avalon: I've never met him, just through email. So, I haven't like talked to him or anything.

Cynthia Thurlow: No, he's one of the most positive people you will ever meet. Like really and genuinely one of the most positive people. And I mean, we've been friends for several years and have spoken on so many stages together. And my husband knows, he and his fiancé and I know them and, like we just really enjoy each other's company. He's a good person, a good human.

Melanie Avalon: I'm really, really excited about that. So okey-dokey. Shall we go on to our next question?

Cynthia Thurlow: Sure, this is from Robin and the subject is "Chronic pain flare." "I enjoy your podcast and I'm loving the diet. However, I'm having a significant flare-up of my chronic pain and wonder if it is related to intermittent fasting. I've been diagnosed with central sensitivity, chronic Lyme, and fibromyalgia. Is it possible there is another variable play? Always too many variables? My wife suggested I ask you. My internet search didn't yield any answers and I'm hoping you also haven't heard of this happening or if it does happen to some that it will subside as my body adjusts. I've been doing intermittent fasting since mid-April and vary between four to eight-hour windows with only occasional lapses when I've been sick. I really love it, so don't want to stop." Thank you.

Melanie Avalon: All right, Robin, thank you so much for your question. So, I thought a lot about this and I have a very casual answer. And then I have what I found from researching, which did not find the answers I was hardcore looking for. I'll start with the research side of things. So, I did a lot of searching for fasting and chronic pain. There's a lot of studies on fasting helping chronic pain. So, there was a really nice review. I think it was a review, but it was called Intermittent Fasting: Potential Utility in the Treatment of Chronic Pain across the Clinical Spectrum. I had never thought about pain, how it breaks down, like all the different types of pain. So, it talks about like all the different types of pain and like how there're six main types and has this really nice chart about how fasting can benefit most of those types with sources. But just in general if you do a search in PubMed or Google Scholar, there's a lot of studies about fasting benefiting pain, which is not the experience that Robin is sharing. I found another study called the analgesic effect of refeeding on acute and chronic inflammatory pain. And it was speaking to the effects specifically of fasting versus eating on pain perception. It was in rodents, not humans, but some of the interesting findings. So again, I don't know how much of this applies to humans because of the rodent aspect. But they did find that both fasting and feeding helped pain, but that for fasting in the rodents it was only in the second half of the fact that they started experiencing the pain-relieving effects and fasting helped only the inflammatory type of pain and not mechanical, whereas food seemed to help both. Again, that's nuanced I don't know how much of that applies to humans, especially when the majority of the studies that I could find were that fasting helped pain, my casual, non-scientific sort of N of 1 I haven't experienced it but I feel like I've seen all people talking about this, a lot of people will say that when they start fasting, whatever issues they have, can get worse before they get better. And I don't know if it's like a healing crisis or a detox effect or what's going on. I mean it does sound sort of like that rodent study where it said the pain-relieving effects started in the second half of the fast. So, have you heard that Cynthia, where people say that it gets a little bit worse before it gets better with fasting?

Cynthia Thurlow: It's funny, I always think about food-based sources of inflammation that can be exacerbated, especially with someone that has chronic Lyme, I think there's a lot to unpack there. I mean, you've got a chronic inflammatory response syndrome. And I can come at this question with many different angles. More often than not, people feel a whole lot better as they're pulling things out of their diet. I wonder if there's a diet variable that hasn't been examined that may be making things worse in conjunction with fasting.

Melanie Avalon: Yeah, I would encourage you, Robin, to keep on with the fasting, I would imagine there are other variables at play, and I can't see how the fasting would continually perpetually continue to make things worse. I would probably stick it out and see what happens and see if it gets better. And definitely, like Cynthia said, look at other potential issues for what might be going on there with food and things like that. Talking about, Cynthia, where like when people start fasting, they experience things. I don't know if it's because the body is like finally cleaning up and tackling stuff, but I feel like people will experience, I don't like using the word healing crisis because that sounds very woo-woo but do you know I'm talking about in this idea?

Cynthia Thurlow: I do, again, I'm going to come out this as a clinician, and from my perspective, if there's this upregulation of autophagy and there's some degree of deeper healing that's ongoing. And then on top of that their detoxification pathways aren't properly opened. I mean that could be contributory. I'm just looking at this as just from the perspective that we know, we detoxify every day, we poop, we pee, we breathe, we sweat. But the two main sites of detoxification where our body is getting rid of toxins, breaking down medications, etc., two phases that occur in the liver and then the bulk of toxins are then hopefully excreted through the digestive system and the gut. And so, I think there're many variables at play when people tell me that they're having an upregulation in pain, I believe that but obviously, I think that there's probably a component to this that is probably not completely clear in the question. And it's not a criticism of Robin, I'm just saying that chronic pain people just have an upregulation in inflammatory cytokines and other inflammatory processes. And there could be something else going on. When people tell me they have fibromyalgia and they have a tick-borne illness. There's a lot going on. From my perspective, I think it's digging deep, anti-inflammatory nutrition, removing the most common predicators of inflammation in the body, the gluten, grains, dairy, alcohol, sugar, soy in conjunction with fasting can be really powerful. But I would also want to ensure that Robin has taken the steps or is leaning into opening up those detoxification pathways that could be exacerbating why there's a pain response.

Melanie Avalon: Yeah, I think that's great. Another thing I was thinking of, this is not probably what's happening with her, but it's just an example of something where something might get worse before it gets better, people will talk about when they go on, like a carnivore diet, and they have oxalate dumping, things like that where some sort of restriction for whatever reason causes a release of a compound or toxins or a stir up of something else.

Cynthia Thurlow: This plant-based defenses are real thing. I think that for many of us, obviously if you have chronic Lyme, you've had multiple rounds of antibiotics. There's no question you've got some degree of hyperpermeability of the small intestine. There's a lot that can go on. So, from my perspective, those are the people who tend to be the most sensitive to those plant-based defenses, whether it's oxalates, whether it's saponins. There're just so many variables that could be impacting that. And I find that even those of us that are abiding by like a gluten-free diet, I always think about almonds as the best example like they're proliferative and keto and low-carb products. But the oxalates can be a huge hindrance to, really dampening down the inflammatory response in the body. And for a lot of people, they may get pain, others may get diarrhea, they may have abdominal pain. It's interesting I interviewed an oxalate expert on the podcast.

Melanie Avalon: Who'd you interview?

Cynthia Thurlow: Monique, and she trains underneath, who's that woman? It's like Sharon Sandy.

Melanie Avalon: Sally Norton and Susan Owens mixed up.

Cynthia Thurlow: Yes, it's one of the two. And so, she trained with her and she's in a wonderful resource and all her content is leaning in the oxalate. I was stunned at how much I learned. And so, for me, I don't tolerate a lot of the heavier oxalate foods and still don't to this day. And I think a lot of it had to do with the 13 days of being hospitalized, a lot of antifungals, antibiotics for six weeks, and my gut's probably still healing. So, when I look at this, there's a lot of different things that could be going on. But I would start with nutrition as being a huge driver in the detoxification.

Melanie Avalon: Yeah, I'll put a link in the show notes. I had Sally Norton on my show. The oxalate is one of those topics where I don't normally think about it and I think a lot of people don't normally think about it. But then like you just said, when you hear the information about it, it's mind-blowing. It's like, "Oh, maybe this actually is a major issue."

Cynthia Thurlow: Yeah. And I just had Bill Schindler on the podcast. I know you've had him on your podcast. We talked about oxalates and I said if you look at them under a microscope, they look like little crystals. And I said is it any surprise that these plant-based defenses are designed to protect the plant, but in someone who's susceptible to them, like me, this is why my mother, I've got an Italian mother, she's always trying to get me to eat more greens. And I finally had to say, I was like leave me alone about the kale and the spinach. I'm like it doesn't agree with me. And someone else, it's probably absolutely fine. But for me, I know exactly what it does to my digestive system. It just reminds me that, there's a very fine line with a little bit and then enough that will provoke a flare. And I'm just not willing to go there.

Melanie Avalon: Yeah. I'll also put a link in the show notes. My app Food Sense Guide has oxalates as one of the compounds that it shows if people are curious about the levels of oxalates in food. So, you can get that at melanieavalon.com/foodsenseguide and we can put a link to the interviews with Bill Schindler. He's so amazing.

Cynthia Thurlow: He was lovely and it was funny. I make my husband listen to my podcast episodes. He was like he's talking about bugs and he's talking about organ meat and he was like, "I got to meet this guy, he sounds amazing." And I said, "No he's a complete realist." Like, he'll tell you his kids didn't love the insects, but he talks about the value of cricket flour and just being open minded to the fact that back in paleolithic days you just ate what was available. You weren't picky about like I'm only eating muscle meat, I probably would have starved. But yeah, I'm not the most foodie adventurous, I'm not eating the cartilage and organs every day and goodness. I like Pluck though. Have you tried Pluck? 

Melanie Avalon: No, what is?

Cynthia Thurlow: So, it's like an organ meat-based seasoning. It's really good. We'll have to link it up in the show notes.

Melanie Avalon: Wait, that sounds so cool. Wait, it's made from organ meats, but it's a seasoning, wait.

Cynthia Thurlow: Oh, it's a chef that created it, James Berry, mm-hmm. I have had him on the podcast.

Melanie Avalon: Wait, this is so cool.

Cynthia Thurlow: Yeah, and it's really good. And actually, they came out with some new flavors. And so, the spicy is really good. Actually, I like all of them. But we'll link it up, we'll give you my discount code. But unlike anything that can get organ meats, in general, more accessible, to me if I throw it over deviled eggs, it's no big deal. But if I sat down and ate a piece of liver that probably wouldn't happen. So, I think the understanding is trying to make these things accessible. I know Bill does a great job with that. James Berry does a great job with that and he's a chef, and I just really appreciate people trying to find clever ways to get people eating more nutrient-dense foods.

Melanie Avalon: I'm looking this up. Okay, so like their main one, like the normal all-purpose one so it has a blend of liver, spleen, kidney, heart, pancreas with onion, salt, paprika, lemon, pepper, garlic, parsley, mustard seed, thyme. Wonder if they have one that's AIP friendly. Let's see pure. Let's look at the pure one.

Cynthia Thurlow: I think that's just organ meat.

Melanie Avalon: Okay, yeah. And then Zesty Garlic, let me look at that one. I like doing online shopping. Wait, this is so cool.

Cynthia Thurlow: Yeah, and they're really good. And so, James is like a real chef. And I love just how clever he is.

Melanie Avalon: Friends, I want the Zesty Garlic one, it has liver, spleen, kidney, heart, pancreas, and then onion, garlic, lemon peel, salt, carrot, garlic, cabbage, parsley, oregano, marjoram, basil, and thyme.

Cynthia Thurlow: Totally good. And spicy is good, too. We're kind of spicy people. We like a little bit of spice, my husband more so he does than I do. But it's going to be part of our holiday gift list because I think it's just a fun way to get people exposed to eating organ meat in a way that's not scary. Like I'm not going to sit down and eat a plate of spleen although I can respect those that do.

Melanie Avalon: Yeah, and they actually do list on their website if it's AIP or not. Super cool, that never occurred to me, that's smart. And then there's a lot of people like there's some company that makes, it's like breadcrumbs, but it's like made from meat. Do you know what I'm talking about?

Cynthia Thurlow: Oh, is that like the pork panko?

Melanie Avalon: Yeah, I think so. It's like they have it like chicken.

Cynthia Thurlow: Yeah, it's a little salty. I like the idea. We tried it and it was so salty. And I was like, I like salt but it was a little too salty for me.

Melanie Avalon: So, another company actually reached out to me called Safe Catch?

Cynthia Thurlow: Yeah, they reached out to me, I think I told you about the scallops with them.

Melanie Avalon: The scallops you told me about were-- because I read it down to look them up was Seatopia?

Cynthia Thurlow: Oh, they all run together.

Melanie Avalon: Seafood is my thing. So, I've been like taking notes. I literally have written down in my agenda to look up your Seatopia scallops. So, you like those?

Cynthia Thurlow: I thought they were good. I like to buy fish the day of-- that's my husband is a fisherman and likes to go deep sea fishing. And so, he's super picky about seafood. So, we tend to buy it the day that we're going to eat it. So, I think it's super convenient. Like I think ButcherBox is awesome in terms of like, meat shows up at my door, I don't have to go to the grocery store. I'm not 100% sold on seafood being sent to my house. I'm not there yet.

Melanie Avalon: So, I'll comment on the seafood aspect. Often times when you're buying it fresh, it's actually less fresh than frozen. Because frozen, they freeze it right there. And so that stops histamine production, and basically just freezes it in time compared to when you buy it at the store. If it hasn't been frozen in between which sometimes they freeze it and thaw it again. But regardless, it's a longer shelf life where it's been not frozen which is interesting. I think a lot of people don't think about that, which is why I'm all about the frozen. So, the Safe Catch, the reason I really, really like them is they have tuna and salmon and they test all of it for mercury. And I just think this is such a problem, especially with tuna because with tuna, there're so many different species and so many different sizes. So, the mercury levels in tuna can range, some tuna can be low mercury, but some can be really, really high. And so, they actually test, so all of their tuna test to be super low in mercury and the same with the salmon and it comes in, they just sent me a box, but it comes in pouches. So, I'm really, really excited that they reached out to me, they gave me a coupon code. So, this will only be through the end of the year. So, stock up now. And this would be a great thing to stock up on because like I said it comes in pouches. So, you can just stock up. You can get 20% off with the coupon code MELANIEAVALON. I'll put a link to that in the show notes. But their website is safecatch.com, which is easy. But yeah, going back to the fish thing because I'm like such a fish fan, you can always ask at the counter. Like if it's been frozen or not frozen or like what the deal is with it. Oftentimes, it's just a little fun fact at Whole Foods, half of the time this stuff that they have in the fish counter, is just a thawed version of the frozen bags that you would buy in the frozen section. Like they do with the shrimp. They do that with the barramundi, I think they might do it with the salmon. So, it's kind of crazy.

Cynthia Thurlow: Awesome. Now, it's always good to learn about options that are out there that are safer. I think after my mercury issue about five years ago, I've just been very conscientious about sporadically eating fish and not eating it often.

Melanie Avalon: Yeah, once you have that mercury toxicity problem and it's something where you can just stop me because I'm so passionate about this subject. I'll talk about it for an hour, but it's something where you don't see it, like you don't see the mercury in fish. So, if you could see the mercury, I promise you people would not be putting even moderate mercury species of fish into their mouth. I've said this a ton of times but if you look at like the spread and you take a piece of tilapia that has the lowest amount of mercury possible and you compare it to a piece of swordfish that has the highest amount, it can be 300 times. So, if you eat one piece of swordfish that could be like eating 300 pieces of tilapia for the mercury in one meal.

Cynthia Thurlow: My mom would throw a sea bass, like fixation for a long time.

Melanie Avalon: Chilean sea bass?

Cynthia Thurlow: Yeah.

Melanie Avalon: Oh, I know. It's so good.

Cynthia Thurlow: Yeah, and when I tell you it was like years. That's like every time we showed up, she went from being vegan to eating fish and eggs and we were very happy about this. And now she's back to eating meat. But the joke was, she would buy the most massive piece of sea bass and sea bass is wonderful, but it's like one of those overfished fishes that's why it's so expensive, that's the other thing is like trying to get acclimated, like being open to trying different things. I think that's important, just being open minded is certainly very helpful.

Melanie Avalon: Yeah, definitely. When it comes to the fish. I actually have a blog post, I'll put it in the show notes. I talk about the fish that I will eat because I really only will eat. I'm very, very limited. I'll eat scallops and shrimp because they're so low on the totem pole. I'll eat farm salmon, I won't even eat wild salmon with the exception of this Safe Catch, which is very exciting. And then I eat responsibly farmed tilapia if I know the source and then I'll eat Australia's barramundi and then when I go out, I might get like, sole or trout or something. It's funny Gin and I had completely different food tastes. So, she was like not about the fish at all. [chuckles]

Cynthia Thurlow: I grew up at the shore, for anyone that's from New Jersey, the shore, the Jersey Shore. And so, we had a lot of fish growing up. And it wasn't really until, probably until I got to Baltimore, because Baltimore's on the water and there's just a lot of like crabs. And I mean, you just eat a lot more shellfish and fish in general. And then I met my husband who's from Annapolis, and we don't eat a ton of fish because my kids don't love it. And it just isn't worth it, it's expensive. They like shrimp, so we do shrimp, but my husband and I will usually get fish for ourselves and then give the teenagers the meat, which is what they want.

Melanie Avalon: Yeah, it's interesting, that fish seems to be more of an acquired. "Oh, my queue is moving, okay, okay, I'm sorry, well, okay, okay. I might have to-- Oh, it's moving, I'm like 1,288 people in front of me.

Cynthia Thurlow: Oh my God.

Melanie Avalon: For the past five hours it's been at 2,000 plus and now it's just oh, 1125, I'm going to get in in a second. Okay, okay, I will just say about the fish. Sorry, this is real-time, real-time Melanie getting her Taylor Swift tickets. 950, I'm going to have to jump it a second, 762. I'll just say about the fish really quickly. It's interesting that it seems to often be an acquired taste. I feel like kids shy away from it. 

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Melanie Avalon: Okie-Dokie, shall we go on to another question?

Cynthia Thurlow: Yes.

Melanie Avalon: So, we actually have two questions and they go together, sort of, they're similar topics, so I thought I would read them together. So, we have a question from Therese. The subject is "Repetitive routines or mix it up." And Therese says, "Hi, love your podcast." I recently started IF and the first weeks, I simply followed the 16:8 method. I found an app that has great programs and found a program for weight loss and the setup seems to be switching it up with different intervals of eating and fasting. I think of it almost as when you exercise you get best results when you switch it up by doing both cardio strength and different types of intervals. Does weight loss via IF get better results when you're not letting your body get used to a steady rhythm, but rather surprise it with different internal windows of fasting and eating." And then James, his subject is "Constantly changing fasting windows," and he says, "I started IF about a month ago using the BodyFast app, which recommends a different program every week, 24-hour fast 16:8, 20:4 and everything in between to prevent your body getting used to a pattern. I also move fasting periods myself to allow social occasions. I have heard you talk positively about keeping the same fasting rhythm. What is your view on switching schedules in these ways?"

Cynthia Thurlow: Well, Therese and James, if you are at all familiar with my work, I am a huge proponent of variety as it pertains to nutrition, exercise, and a fasting program. Obviously, for women that are still menstruating there are times in the menstrual cycle when we should lean into more fasting as opposed to others when we should not. Men and menopausal women have the advantage of not having as much hormonal fluctuation. I typically do recommend-- our bodies get lazy, if we are doing the same thing, think about if you did the same workout at the gym every time you went, over time your body gets acclimated and you're no longer challenging it. And so, we want to think about exercise and a fasting regimen is a form of hormesis, beneficial stress in the right amount at the right time to keep things changed and challenged. And I'm absolutely a proponent of different types of exercise, which includes strength training, high-intensity interval training if that's appropriate for you, NEAT, which is just being physically active throughout the day that's not structured exercise. And then, leaning into the fasting piece. In fact, I was listening to a video of Chris Kresser today and he was presenting some new research, looking at women in particular in fasting and a lot of it goes back to things that I talk about, you have to have a large enough window to get enough protein in in your feeding window, not having to narrow the window, getting concerned with over fasting losing muscle mass. And so, there's a fine line for each one of us. And for me personally and I'm just going to use myself as an example, I'm in a very healthy weight, I don't want to lose muscle mass. I don't do long fasts. There are people to do them and if you have a lot of weight to lose, you're struggling a bit maybe you needed to have like a digestive reset, you have more latitude with that than someone that's already at a goal weight or already pretty metabolically flexible. I think it's a very individual decision, but I'm absolutely a fan of varying what we eat, when we eat, and not doing the same types of exercise every day. What do you think, Melanie?

Melanie Avalon: Yeah, so I've thought about this a lot in general, with the exercise and everything, I definitely agree that mixing it up is so key including all those different types, like you were saying, because that's really most in line with how we would have evolved as a species, we weren't going to the gym and like working out for 30 minutes every day or like doing the same thing every single day, and we were moving functionally, we weren't just exercising this one muscle to, really aesthetically the way it looks. So, health-wise, exercise, mixing it up, I think is great. With fasting, I think as well, it can be great to mix things up. But I think the complicated nuance is, because I just know how I personally am, which for me, like it really works following the same fasting schedule. And when I go off of it, I don't feel as well. And I think part of that might have to do with the peripheral clocks of our body are driven independent within themselves. I was actually just reading about this in a book that I'll probably talk about next episode because have you heard of-- I think I mentioned it before, it's the Oldest Cure in the World?

Cynthia Thurlow: No, I have not.

Melanie Avalon: It's by Steve Hendricks, it came out September 6 and it's the deepest dive into the history of fasting I have ever read. So, the subtitle is Adventures in the Art and Science of Fasting. I'm going to interview him which is really exciting, but its mind blowing some of the things I've been learning. But in any case, that part I was reading last night was about the SCN. So, the master clock in our body, which light affects and which drives a lot of our circadian rhythms. But then all of our cells have peripheral clocks and they can function on their own. So, they can be informed by the SCN, but they can also be completely informed on their own. And so, eating is actually a very intense clock within us and it's on its own rhythm and it's often based on how we're eating. And so, the reason I'm bringing this up is I find for me personally that if I follow my same fasting window of a one-meal-a-day situation at night, then I feel good during the day, I'm not hungry during the day, I'm hungry at night. I feel good at night, I find it that when I break it, it messes with that clock for me, and I just get ravenous. So, like if I were to like widen my eating window, which works really well for a lot of people like to have those days where they have a longer window. For me it like just doesn't work, it would just make me hungry and miserable and not feeling good. And so, I wonder if with the fasting it's something where people really should take it individually for how it affects them. And, how do they do with mixing it up or not mixing it up? I think some people will do better with mixing it up and some people won't. Do you have thoughts on that concept?

Cynthia Thurlow: I mean, I do. I just think overall if the bulk of the population here in the United States is not metabolically flexible, they have to change things up. I see where you and I are both coming from, honoring our bio-individuality, honoring the fact that I always call you the unicorn. And I mean that in the most affectionate way, like manner, not in a pejorative way. But like, I can get up early, I have to go to bed early, you can stay up late, you like to sleep in. So, it's like figuring out what works for our bodies. But knowing that the bulk of people are metabolically inflexible here in the United States and most westernized countries, changing things up in some capacity, even if it's, you lift an extra day that week, or maybe you go an extra hour without eating or maybe you shorten your window, like some degree of flexibility I think is important for us. And that's what I feel like intrinsically. And certainly, after coaching 1000s of people through this process, there are always exceptions, so let me be very clear. But I feel like most of us need some degree of alteration in schedule. Today's a good example, over the last several months, I've been leaning into eating a little earlier in the day and closing my window a little earlier and that has worked really well for me. But today, I didn't eat till I came home. So, I had an unintended almost 20-hour fast. And that's not my norm. But I was like, I'll be totally fine. I had a big meal, I'll have one more smaller meal before I go to bed, and I'll be good. Unfortunately, when I trained 1000 years ago, the mindset and methodology was you treat every patient the same in terms of if they have blood pressure problems, everyone starts with this medication at this dose. And I've just learned to be a little more thoughtful and a little more individualized. So, some type of variation of what you're doing it doesn't have to be dramatic, can be very helpful.

Melanie Avalon: I'm really glad you said that nuance and that's something I was actually going to comment on. I wasn't quite sure how to say it and I think you said it really well. So, for me, the way I would bring in variability in a way or switching things up would be like fasting a little bit longer. Like it would be like a slight tweak rather than just a completely different eating window or I think I could get similar benefits possibly by changing completely what I'm eating in my eating window, like, be it macro wise or whatever. So, or even like a low-protein day just to like switch things up, or switching to a low-carb day to switch things up. I definitely think there is some magic there with the metabolic [unintelligible [01:03:13] piece. I do wonder though if for some people just sticking it out, at least while they're metabolically inflexible to a certain window might be important until they're metabolically flexible. I don't know if I'm articulating it correctly.

Cynthia Thurlow: No, no, no, I totally agree with you and in fact, I had someone on Instagram the other day. And I know of her, she's very thin, she's an exercise person. She kept saying I don't know why you don't just tell people to intuitively eat. And I said that works fine if you're metabolically flexible, but if you are not, you can't and to think that everyone can is pejorative. And so, I have to very politely say that every time because she always comes back and says, "Don't tell women over the age of 50 they can't do this and this and this." And I'm like, "Well, maybe you're an outlier." But generally speaking, I'm trying to come from a place of kindness, but it's clearly a triggering topic. I think what I hear you saying is very aligned with what I think that we have to be gentle and kind and realize that some people are ready to jump in feet first and some people have to like dip their toe in the pond. They're terrified of adjusting what they're doing and so just acknowledge what resonates for you what feels good. We would never advocate that people do something that's beyond their comfort level. Like if you said to me, I want you to play to organ meat, I would struggle with that I have to be completely upfront, it might be just as scary as suggesting someone to change their feeding window. So, I think just entertaining the possibility of making subtle adjustments can be beneficial.

Melanie Avalon: Yeah, I cannot agree more and it's really glad to hear your thoughts about that. I often wonder, especially in the beginning when people are fasting if they hadn't flexed their fasting muscle yet, they might want to switch things up, but it's because they haven't stuck to it long enough to really get in the flow of fasting. So, I get nervous about people trying to be too intuitive, too soon. Some people are great though being intuitive, but some people aren't. You just have to know who you are and what works for you.

Cynthia Thurlow: Yeah, unfortunately, I sometimes see very metabolically flexible people shaming other people for not leaning into intuitive eating. I'm like, they can't it's not that they don't want to, the hormonal regulation in their body is off and they just can't lean into that. So, I think that we have to be kind and open minded and compassionate, I think that goes a long way.

Melanie Avalon: Exactly, even for me, it would be really, really hard. And it's not a skill that I feel like I need to learn. I don't feel like I need to be able to intuitively eat a brownie. Maybe if I eat a brownie that makes me really cravy and want more food and maybe that's just the way it is. And maybe I can just know that about myself and not feel bad that I can't, moderate things like that. I think it should be okay if you know that certain foods are troublesome for you to abstain if that makes you happier.

Cynthia Thurlow: Yeah, no, no I think it's interesting. The thing that I'm always intuitive about is carbs, I don't count carbs, but I have a good sense of how much I'm eating. And so, like yesterday is a good example, I wanted blueberries. And by some miracle, my 15-year-old hadn't eaten them all yet. My husband bought them on Sunday. And usually, he finishes off any fruits that's in the house within 24 hours. And so, I had some blueberries and my husband was like, I'm actually glad to see you eating some blueberries. I said, "Well, I wanted them." And it was like, my body wanted something healthy, and I'll lean into that. And so that's the intuition. But I acknowledge that not every person and quite frankly if we look at statistics 7% to 8% of Americans are metabolically flexible. So, the average person can't do that. I think it can be validating to hear that and also gives people something to work towards.

Melanie Avalon: All righty. Well, this has been absolutely wonderful. So, a few things for listeners before we go. If you would like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. The show notes for today's episode will be at ifpodcast.com/episode295. You can follow us on Instagram. I am @melanieavalon, Cynthia is @cynthia_thurlow_ and I want to apologize to you, Cynthia, for my craziness today and to the audience for my craziness, but I have the Taylor Swift tickets now. [chuckles]

Cynthia Thurlow: Yeah, so you got your tickets. I was saying to Melanie, the ticket prices have gotten so insane. I was like how do young people afford to go. I went to so many concerts when I was a teenager and a 20-something, kind of makes me sad.

Melanie Avalon: I know. It's crazy.

Cynthia Thurlow: That's probably why I have tinnitus. I have chronic tinnitus, a chronic ringing in my ears, and my working hypothesis from my ENT, it's all those concerts you went to and I was like probably Red Hot Chili Peppers was especially loud many years ago.

Melanie Avalon: Oh, I bet. So, we're going to like rock and roll-type concerts?

Cynthia Thurlow: I've been to everything. It runs the gamut from alternative music when I was in college is now considered very mainstream. But I've seen Red Hot Chili Peppers, I've seen U2 multiple times. I'm dating myself, but yeah, but now it's like I have no interest in being in a big loud crowd. I'm like okay I can watch everything online, I'm good. [laughs]

Melanie Avalon: Well, I go to concerts. I'm going to Mannheim Steamroller in a few weeks and I'm going to Trans-Siberian Orchestra, but I don't normally-- and I go to musicals that doesn't count. [laughs] I know I'm not a concert person except for Taylor Swift.

Cynthia Thurlow: Well, I'm very excited for you.

Melanie Avalon: So "Oh, my goodness." Okay. Well. This has been wonderful. Thank you again, sorry again, and I will talk to you next week.

Cynthia Thurlow: Sounds good.

Melanie Avalon: Bye.

Thank you so much for listening to The Intermittent Fasting Podcast. Please remember everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Dec 04

Episode 294: Creatine, Excess Skin, Toning Up, Clean Hair Dye, Hormones, Caffeine, Cortisol, Hormetic Stress, Jet Lag, Hydration, Melatonin, And More!

Intermittent Fasting

Welcome to Episode 294 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

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SHOW NOTES

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Episode 292: Creatine, Brain Health, Sex Hormones, Muscle Building, Insulin Sensitivity, Sarcopenia, Andropause, Mood, Motivation, BDNF, And More!

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Listener Q&A: Dillon - Too “Skin'ny"

Listener Q&A: Sarah - Toning Up

Listener Q&A: Marili - Hair dyes

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The Melanie Avalon Biohacking Podcast Episode #148 - Dr. Michael Breus (Part 2)

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The Melanie Avalon Biohacking Podcast Episode # 3 - Dr. Kirk Parsley

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Ep. 233 How to Optimize Your Hormones & Metabolism For Vitality

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 294 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time and get ready for The Intermittent Fasting Podcast.

Hi friends, I am so thrilled to announce that my next AvalonX supplement is official and almost here. It is something that I currently take every single day of my life and that is berberine. I first started taking berberine when I first started using a continuous glucose monitor which constantly monitored my blood sugar levels, I found that taking berberine had a dramatic effect on my fasting and post-meal blood sugar levels. Berberine is a plant alkaloid which has been shown to rival metformin when it comes to reducing blood sugar levels without any of the side effects. Blood sugar regulation is so important for health. It's a key factor in metabolic syndrome and preventatively taking care of your blood sugar levels or treating high blood sugar levels is so, so important for health and longevity. That's why I am thrilled to be making a berberine supplement. And it's not just blood sugar control, berberine has been shown to have so many benefits. It's been shown in studies to beneficially modulate adipose tissue. It can actually help change the composition of your fat to a more healthy profile. Think less visceral fat, which is the inflammatory fat found around our organs. It's also been shown to have beneficial effects on PCOS and reductions in inflammation and is a potent stimulator of autophagy which is one of our favorite things. Berberine has also been shown to have a beneficial effect on blood lipids, which is huge, and I wanted to make the best berberine on the market, we looked so hard to find a source of Berberine that tested to be high potency and free of pesticides. Yes, we did third party lab testing on our source as well as testing to assure its quality. It has been tested multiple times for toxins including heavy metals and mold and has no problematic fillers. It also comes in a glass bottle to help prevent leaching of plastics into ourselves and the environment. This is the berberine that you want I promise and it is coming at midnight of Friday, December 16. To get all of the updates about it definitely get on my email list that's at avalonx.us/emaillist, we'll be announcing the launch special on that list. You can also get text updates and a 20% off coupon by texting AVALONX to 877-861-8318. That's AVALONX to 877-861-8318.

By the way, if you would like to get a CGM to monitor your blood sugar levels and see just how berberine is affecting it, you can get $30 off NutriSense CGM at nutrisense.io/ifpodcast with the coupon code IFPODCAST, that's nutrisense.io/ifpodcast with a coupon code IFPODCAST. If you'd to get any of my other amazing supplements at avalonx.us, use the coupon code MELANIEAVALON to get 10% off sitewide at avalonx.us. You can also use that coupon code MELANIEAVALON to get 10% off sitewide and my fantastic partner MD Logic Health for that go to melanieavalon.com/mdlogic.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. And then in our bodies, studies have shown they do things, like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years. 

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo, and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. Also make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out. You can join me in my Facebook Group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you're thinking of making Clean Beauty and Safe Skincare a part of your future we have, we definitely recommend becoming a Band of Beauty member. It's sort of Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now back to the show.

Hi, everybody and welcome. This is episode number 294 of The Intermittent Fasting Podcast. I'm Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, Melanie.

Melanie Avalon: How are you, Cynthia?

Cynthia Thurlow: I'm doing well. I'm super excited. We're a couple of weeks into the creatine and we're getting such great feedback. It's really exciting. And I have to thank you for encouraging me to do my own supplements as opposed to white labeling supplements as I had been doing.

Melanie Avalon: I'm so excited for you. By the time this airs, it will have come out right? This airs December 5th.

Cynthia Thurlow: Correct.

Melanie Avalon: So, just as a recap, why did you choose creatine as your first supplement?

Cynthia Thurlow: I think it had a lot to do with the fact that I was getting more involved in the research. I myself over the last year started taking creatine last fall and was noticing a lot of beneficial gains in the gym, every week increased the amount of weight I was lifting. And that's been really important to me because I psychologically like to know that I'm getting stronger, not weaker with age. And we understand the complex in relationship between how we start losing muscle mass, and frankly bone mass in our 40s. It's really important to help maintain that. My thought process was I want all my supplements to be focused on two key areas. One is maintaining muscle mass and number two is anything that's going to be helpful for supporting brain and cognition. Creatine was an easy first start because both men and women benefit from taking creatine, but in particular, really my life's work is really helping women understand how it can benefit them. And I think there's a lot of common misconceptions, but it's probably one of the most well researched ergogenic aids or supplements that's out there and I just like people to understand how it can benefit them and not just about the muscle piece, but understand there are certain times during our menstrual cycle where our creatine needs go up and why vegetarians or vegans actually need more creatine than the rest of us. And taking into account the changes in physiology as we get older. For all those reasons, I decided that I would keep it pretty simple. I think you and I are in alignment that we'd like to keep the supplements simple so that we know what works or what doesn't work. And so, creatine all by itself seemed to be a good starting point.

Melanie Avalon: It's interesting because it's something that wasn't really hardcore on my radar or I think maybe I was sort of writing it off in my mind, because I associated it with a protein supplement, probably erroneously. And I was like "I don't need to take any protein-related stuff." But I'm realizing more and more how it's not really about that, as all of these other benefits and I've been hearing it pop up on so many places, so many books, podcasts. So, I'm really, really excited to get yours. We were mentioning the vegan thing, there's that one I would say famous, I realized I probably think things are famous that aren't famous. But there's that one well-known study that looks at creatine supplementation in vegans versus omnivores. And it's debated because they try to debate the interpretation of the results. But me reading it, I think it makes a strong case that vegans likely are, needing creatine to have better brain function compared to meat eaters. What makes your creatine special?

Cynthia Thurlow: Well, we really went to the research and it's creatine monohydrate. So, it's a pure form of creatine without fillers, there's no concerns about contaminants. I think the high-quality nature of it, I always jokingly say that you have to be careful where you buy your supplements and who you buy them from. And I just felt that MD Logic was the right company to partner with so that I could get the quality of supplements that I was looking for. But creatine monohydrate is the form of creatine that's best studied. And something that's important for people to understand is that you can't get enough of it from your diet, and just like everything else, we make less of it as we get older. I think for a lot of people, we made the association at the gym bro thing, you think about people that are using anabolic steroids. I just remind individuals that the amount that we're recommending based on the research is much smaller than what bodybuilders are using. It's not as if you're going to get puffy or start retaining water that's not going to happen because we're using therapeutic amounts as opposed to super therapeutic amounts that are used in that population of individuals.

Melanie Avalon: Yeah, I'm glad you mentioned that. I think that was one of the main associations I had in my head, which is why I was miss categorizing it and its potential benefits. And I know I can also speak because I know you're working with MD Logic. So, it's going to be tested multiple times for purity and potency, and for toxins and heavy metals and mold, which is, that's really important to me. How can people get your creatine and you have code for listeners?

Cynthia Thurlow: Yes, the code is CYNTHIA to get 10% off. You can go to cynthiathurlow.com/new-shop/creatine/ and that will get you direct access to a really interesting page of information. And you can use code CYNTHIA to get 10% off and we'll make sure we put that in the show notes.

Melanie Avalon: Awesome. Okie Dokie. So, we will put all of that in the show notes. I do want to share just I mentioned I was going to share something last week. I wanted to share it really quickly because I know with the timing of this, and the holidays for two reasons, all the food festivities coming up and also, I know people are looking for gifts and I think this would be the most amazing gift ever. I have something in my life now that I am obsessed with. I'm beyond obsessed. Do you have a composter?

Cynthia Thurlow: I do not. We weren't allowed to have them in our last neighborhood outside.

Melanie Avalon: So, a brand actually reached out to us wanting to partner with IF Podcast, so I'm hoping we can partner with them in the new year. We were booked with inventory for this year, but I did book them for my other show and it's Lomi. It's a composter that you can have in your kitchen. Friends. Oh, my goodness. I've been wanting to compost for so long, but it seemed very daunting. It just seemed like a big task. I have been throwing away as you guys know, I eat so many cucumbers. I throw away pounds of cucumber peels every night. And now I put all of my cucumber peels and all of my cilantro stems into this wonderful little device. It's like if you think of a crockpot, it's probably the size of two crockpots. But it's very sleek and savvy and quiet and I just have it down on the floor next to my trashcan. I throw all of my scraps in it every single night. I press the button, it runs overnight, and the next morning, it's magically turned into dirt. It is the most incredible thing. And you can put in these little pellets that will make it more microbial-rich dirt if you want to use that dirt to put in the garden or grow stuff yourself. I don't I just actually throw out the actual dirt. But it's becoming one of my favorite things. And I'm so happy it's in my life with all of the waste coming up off the holidays and are looking for a gift. This would be an amazing gift for people. I wanted to share it for so long because I've been so obsessed. So, now's the time, hopefully we'll have a code for them on the show in the new year. But for now, if you go to lowmi.com/melanieavalon, the coupon code MELANIEAVALON will get you $50 off. So, definitely check it out. It's honestly one of my favorite things.

Cynthia Thurlow: That's so awesome, yeah, our last HOA was really strict and so even the crunchy people in our neighborhood couldn't have composters, just silly to me. But maybe this will force me to revisit the concept because I have a husband who likes to garden. That's his thing, he loves planting fruits and vegetables and loves being out in the yard and doing yard work, and maybe that will encourage him to make good use of things that otherwise get tossed or put down the garbage disposal.

Melanie Avalon: Yes, you have it inside. You have it in your kitchen, so anybody can really have it. It's just so cool, the first time you do it too if you haven't done it before, though it's so cool to put in all of these food scraps, and then it's just this nice dirt in the morning and the dirt, it smells really good. It's fruity-smelling dirt for me at least because it's the cucumbers. And yeah, definitely check that out.

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Robb Wolf, who as you guys know is my hero in the holistic health world, worked with the guys at Ketogains to get the exact formulation for electrolyte supplements to formulate LMNT Recharge, so you can maintain ketosis and feel your best. LMNT Recharge has no sugar, no coloring, no artificial ingredients, no junk. They're used by three Navy SEALs teams, they are the official hydration partner to Team USA weightlifting, they're used by multiple NFL teams, and so much more. We have an incredible offer just for our listeners. You can get a free LMNT sample pack that includes all eight flavors. Citrus, watermelon, orange, raspberry, mango chili, lemon, habanero, chocolate, and raw unflavored and the raw unflavored by the way is clean fast friendly, You can try them all completely free when you make a purchase at our link, drinklmnt.com/ifpodcast. You can get this offer as a first time and as a returning LMNT customer. I know there are a lot of returning LMNT customers. The feedback I hear from you guys, "Loving LMNT" is amazing. LMNT offers no questions asked about refunds on all orders. You won't even have to send it back. And this offer is exclusively available only through VIP LMNT partners. You won't find this offer publicly anywhere else. So, again, the link is drinklmnt.com/ifpodcast. And of course, you better hurry if you want to get LMNTs limited-time holiday chocolate medley and we'll put all this information in the show notes. All right now back to the show.

Melanie Avalon: Okei dokei, shall we get into some listener questions for today?

Cynthia Thurlow: Absolutely.

Melanie Avalon: To start things off, we have two questions. I'm going to read both of them because they speak to a similar concept and it's something that we've talked about on the show before. But I really wanted to get Cynthia's input on this and see what she has experienced with her patients. So, the first question comes from Dylan, the subject is "Too "skin"ny." Hey, ladies love the podcast, I started listening in the middle of January this year when I started my IF journey. And I've since caught up and listened to every episode, you're both so funny and encouraging. I'm typically on a 24 routine but often find that I eat all of my food within one to two hours and I feel satisfied. I also do a 44-hour fast once every other week. Since January, I've lost over 50 pounds and have 10 more to go, but I'm at my target weight. I started at 235 pounds, the heaviest I've ever been. I'm also happy with the fact that I'm gaining muscle about as quickly as I'm burning fat by doing occasional HIIT and light weightlifting.

My question is regarding extra skin. I've lost weight so rapidly that I have a lot of extra skin, especially in my abdominal area. Will my body eventually begin to shed the extra skin through autophagy? Do you have any tips for reducing stretch marks without expensive creams or lotions? Any tips regarding this will be greatly appreciated. Keep up the great work. I recommended your podcast to several friends and coworkers and a few of them have started their own IF journeys. One of those converts is a friend of mine who is beginning his residency to become a physician. And by researching several papers and studies is now a major advocate for fasting. Regards, Dylan. First of all, I'm going to say, Dylan, that's awesome about sharing it with doctors because it's really nice to get some of this perspective into the mainstream medical community.

And we have a question from Sarah, the subject is "Toning up." Sarah says, "I've been doing IF around six weeks and I've just been introduced to your podcast, which I'm listening to on catch-up. So, apologies if my question is answered in a podcast that I haven't reached yet. I am doing IF for weight loss and anything extra from clean fasting is a bonus. With large weight loss comes saggy skin, will I have help with this over time or will I need additional exercises to target this? Loving the podcasts. All right, so Cynthia, have you had experience with this?

Cynthia Thurlow: Yes, so thank you to Dylan and Sarah for your questions. And yes, they are very similar in terms of people that have lost quite a bit of weight and are looking to have some improvement in the excess skin. One thing that I say to patients is in many ways when your skin stretches out, it's been stretched out for a period of time, depending on how old you are, obviously if you're a perimenopausal, menopausal it's going to be harder because as we're losing estrogen that is critically important for collagen and elastin formation. That doesn't mean it's impossible but I do find when people have lost large amounts of weight that sometimes it becomes more challenging. Now there are specific types of lasers, there are topical products that can help to some degree. But I would be remiss if I were to say that I think all of that can be ameliorated just with weight loss and fasting. But I think it really comes down to what bothers you and how aggressively you want to fix it.

I'm an advocate of people feeling comfortable in their bodies and feeling comfortable with where they are, but probably if you're feeling doing laser to help stimulate more collagen and elastin and if that's not something that's going to fix the problem or topical things are not going to be aggressive enough, then you could potentially move on to surgical interventions. And obviously, I'm not a plastic surgeon and I can't speak for them. But for a lot of my patients, they end up getting to a point where they want to surgically address this, I have just as many that are comfortable doing nonsurgical options as an aside, but as you are getting more to your ideal weights, there will be some changes to the skin, but a lot of it can be mitigated by, where we are in time and space, obviously a 30-year-old losing a bunch of weight, it's going to be-- they're going to have a better rebound effect than someone that's a little bit older. And just when women have pregnancies and they stretch their abdomens out over a period of 40 weeks, for many people they do get some rebound of that skin and really a lot of it can be genetically mediated. In a very broad context, I think that a lot of it is dependent on what you're doing and what bothers you enough? For some people, they're completely comfortable pulling on some Spanx and going about their day for others that would be problematic, but I would wait till you get closer to your goal weight before examining what options are available. What do you think Melanie?

Melanie Avalon: Yeah, I know Dr. Fung has talked in the past about how one of the things they noticed in their weight loss clinics with fasting patients is that the fasting patients wouldn't experience all or at least the extent of saggy skin effects that people often see with weight loss. And I think he's proposed that it could be something with the autophagy that's going on there helping to mitigate that effect. I do think that losing weight with fasting can potentially have a more beneficial effect on the excess skin and the effects like. I agree completely with everything Cynthia said. This is something where depending on how intense it is, I know Dylan was saying that he was not so much interested in expensive creams or lotions. I do think most creams or lotions are probably not going to do that much. That said I actually do think there is a benefit to some topical treatment especially because you can put these compounds directly on the skin. I would to formulate some sort of cream in the future that might help with skin tightening. That said the most effective thing is probably going to be what Cynthia mentioned with the lasers and the things like that. I actually really, really like-- I've done something called CryoSlim, it's a cold therapy application and a warm therapy that has a really nice skin tightening effect, also building muscle in the area can be great depending on where the area is filling up that area with muscle and having a beneficial effect on the perception of the skin. And especially I've talked about it before, but I've been doing a lot of EmSculpt, which is muscle stimulation-- electrical muscle stimulation and I've actually built a lot of muscle using it. And it has the added benefit if you do the Emsculpt Neo specifically.

It also has a radiofrequency application, I believe it's radiofrequency that also has a skin-tightening and fat-burning effect. And so, people might think that who am I to make a testimony about this? But I think when you do get down to the really intense lingering things, you really can tell what is working and what's not. And I've seen a huge effect on some personal areas doing the Emsculpt Neo in particular. And I really, really like that because you get the muscle-building effects, which is going to have a huge benefit for metabolic health. And then on top of that it seems to have a really nice effect on the skin surrounding the area as well. But then there are also lots of other skin tightening options and I do think there're a lot there. So, you can just like cut those different options out, again that is going to be a more expensive and committed route to go. Shall we go on to our next question?

Cynthia Thurlow: This is from Marilee and the subject is "Hair dyes." "Hello, do you dye your hair? What do you use? Hair dyes have all the nasty ingredients, so I'm wondering what are your thoughts on that. I am bleaching my hair monthly and I'm wondering where all the nasty stuff I'm ingesting through my skin. Also, I'm from Estonia and was shocked in a positive way that Melanie has two podcasts with my fellow Estonian, Siim Land. Best wishes," Marilee. Melanie, what are your thoughts on this?

Melanie Avalon: Also, I did not plan this last week. I know we were talking a lot about Siim Land. I am all about the nontoxic environment, cleaning up our exposure to toxins in our environment. I don't know how much I can talk about it. I feel I talk about it all the time. I'm going to be completely honest and transparent. I haven't done this with my hair dye. I'm actually blonde, I'm dirty blonde, I lighten it, I probably should look more into this, but I've just personally decided that I've cleaned up everything else so much, all of my skincare, all of my makeup, my food, my environment, the hair is the one thing where I'm just going to just do it and I'm not going to stress about it. That said, I know it is probably something in the future that hopefully I will look into more. And I did look into it little bit and interestingly I have a Facebook group you can join called Clean Beauty And Safe Skincare With Melanie Avalon. And people have asked this before, somebody actually asked about this last week, which was perfect timing. And there were about 30 comments of people having suggestions. Some of the things that came up and I would recommend that you do some further research on these because again I don't have experience with them. And I didn't hardcore vet them. Well, a lot of people in the group-- I actually think that the nature of the question was somebody was saying she wanted to use henna and again this would not be for lightening. This wouldn't be for Marilee's issue. But for people who are going dark, she was saying that she was thinking of using henna and her hair girl was saying that it could have heavy metals in it and be an issue. Comments, people were saying they did not have that experience and we're not aware of that and I haven't seen that anywhere else. So, I don't know if that's an issue, but henna is often used to go darker.

There's a brand I found called Light Mountain and again, it's really hard to know if this is greenwashing or not. And by greenwashing, I mean are they just using a lot of words to make it seem really great when it's not, but I think erring on the side of at least companies that are purporting to be more nontoxic is probably a safe choice. On Light Mountain's website they say that the premier natural hair color and conditioner product line, they say they use no chemicals, no synthetic ingredients, only pure premium henna and other botanicals that they've been blending since the 1980s and are leading totally natural line in the natural products industry. So, you could look into them. Another person recommended Tints of Nature, which they actually sell on Thrive Market and according to them they say we use the lowest possible levels of PPD pigments and leave out harsh ingredients like ammonia. They say they ensure that all of the ingredients are high quality and sourced from responsible suppliers who do their bit to protect the planet. They believe that natural ingredients are better and they prefer to use kind and gentle natural and organic ingredients that give love back to your hair. They leave out synthetic nasties like ammonia parabens, resorcinol, I don't know what that is, and sulfates and they say the only time they use synthetic ingredients are when they cannot find a suitable natural alternative. That might be an option to look into. A lot of people have recommended Madison Reed, it was hard for me to evaluate if they are great or if it was greenwashing. But in any case, it's probably better than what most people are normally getting, so that might be something to look into. So those are the options that I am recommending. Cynthia, do you dye or color your hair?

Right now, I'm doing a lot of Lowlights because we're heading out of summer and I actually like a really ashy blonde. With each kiddo, my hair got darker and so I do partial highlights throughout the year. I don't use bleach because I have that ashy look and so there's a constant battle to keep that ashy look and not be gold and so bleach for me doesn't really work well. Admittedly my hair is definitely an area where I struggle a bit to find cleaner products. I use things like argon oil to help with frizz and that's obviously clean that's made in Morocco and you can find organic derivatives. But I would say the two that I'm most familiar with the clean hair dye options or cleaner, Madison Reed as Melanie also just identified and also there's a company called Arctic Fox. I have a couple of girlfriends who use that, it's vegan. According to them it works really well on lighter-colored hair, but can work well on dark hair as well. Beyond that, my hair colorist, we try to find the cleanest options that are available but this is definitely an area where I'm constantly a work in progress because I have very coarse hair and so for me using the super clean shampoos generally don't-- They don't clean my hair all that well and they don't moisturize it sufficiently so we're constantly trying different things to find cleaner options, but Arctic Fox and Madison Reed are two options and I think those are available to people that they can purchase on their own. You don't have to purchase it through your hairstylist, but yeah there's not 100% consensus on finding things that are easier on our hair and nontoxic. I know a lot of people, you're starting to see emerging trends. I'm starting to see a lot of women that are middle-aged that aren't dyeing their hair anymore. For me, I don't have a lot of gray so that wouldn't per se necessarily help me out, but I think for each one of us we have to pick our poisons if you will, and for me right now I just haven't been able to go 100% clean on shampoo or hair dye, but I definitely endeavor to keep looking for cleaner, safer options.

Melanie Avalon: So, on the shampoo, conditioner front. I do love, love, love, Beautycounter's shampoo and conditioner. It doesn't weigh my hair down. I just really love how it makes my hair feel. They used to be called Free & Clear. I think they're now called Vanicream, but they make a completely unscented allergen-friendly shampoo and conditioner. I like their shampoo. I like to pair actually their shampoo with the Beautycounter conditioner. Because I find if I do the Beautycounter conditioner and shampoo sometimes, it's too moisturizing for me. I also love their hairspray. I wish Beautycounter would make a hairspray, but I really, really like, like I said I think it's called Vanicream now. I really liked their Free & Clear hairspray, it has no perfumes and works really well. So, I'll put a link to that in the show notes as well. I can't believe I used to spray my whole face with all this hairspray that had all those perfumes and compounds in them. I shudder thinking about it. Now whenever I go get my hair done, she always wants to bring out the hairspray at the end. I'm like no, don't. Don't spray that on me.

Cynthia Thurlow: I think it's challenging and I don't pass judgment on people that are navigating how to make better options. It's interesting we're doing a webinar on Sunday night talking about cleaner options for your home and for your makeup. And I'm very transparent and just share with people that there are some things that are easy for me and some things are harder, and you just do the best that you can. And if you're avoiding 80% of what's out there, you're doing pretty darn good. So, don't beat yourself up.

Melanie Avalon: Yeah, I have that experience recently because I really wanted to try eyelash extensions. I was going on a trip to Austin and so I wanted to just try them and not have to deal with mascara. And I was researching it I was okay, well, this is going to require chemicals. But you just got to choose what you-- the cost benefit of everything. I did them, they were super fun, I will say that I took them out and I freaked out by how much my eyelashes seemed shorter. And it's hard to know if they actually were gone or if they just seemed so different compared to the extensions. But then that's the situation where-- so the way I start with eyelash extensions, putting them on the application process seemed more a one-off compared to a chronic administration. When I took them off, I was I've got to find a growth serum. I really wanted to find a clean one. And oh, my goodness, I am obsessed, friends, get this now or if you need gifts for anybody. I tried DIME Eyelash Growth Serum, it's amazing and that's something if you're going to be using it, you're probably using it every single day. So, it was important for me to find a clean version of it. The growth, I'm so excited because now I honestly think I'm going to have fuller more lush lashes than I did even before the extensions because I'm using this every single day, I'm just going to use this every day for the rest of my life. So, if you go to melanieavalon.com/dime the coupon code MELANIEAVALON will actually get you a discount sitewide but definitely try that lash growth serum. But yes, I definitely agree with you Cynthia about-- do the best you can, do a cost-benefit analysis, and just do what works best in your life.

Cynthia Thurlow: Absolutely, and I've had good luck with castor oil, that can be helpful for people that feel their eyelashes aren't as vibrant as they once were. I know for my eyes are super sensitive, so I could never be one of those people that could do eyelash extensions. But when I do special events, I'll do the individual eyelashes that are just temporary and I'll do those, and I can always feel like by day two my eyes are, "Please get this stuff off." I think a lot of it has to do with the glue. I certainly have had some friends who've done really well with eyelash extensions and others that have struggled a bit, so lots of options there for sure.

Melanie Avalon: Well, I'm really glad I did them, they were super fun. If I hadn't done them, I wouldn't have looked into this growth serum. And now I'm just really excited, it's like I'm going to have the most luscious eyelashes ever naturally. I had one more comment "Oh, castor oil," castor oil just makes me want to cry. When I was in my really-- my face when I was really struggling with constipation, people will recommend castor oil to fix that. Have you ever taken castor oil? Have you ever--

Cynthia Thurlow: I never have.

Melanie Avalon: I can't even think about it. It is the worst? It is the most foul thing I have ever put in my body, the taste of it is just mm-hmm. Yes, castor oil makes me shudder. But that's different than you're saying putting it on your eyelashes.

Cynthia Thurlow: Yes.

Melanie Avalon: Very cool.

Cynthia Thurlow: Yeah, I have some friends that have had really good luck with that.

Melanie Avalon: Nice. If it didn't make me want to cry, I would try that.

Cynthia Thurlow: No, we don't want to induce crying, that would be bad.

Melanie Avalon: Listeners, though, can check out the show notes. We'll put links to everything that we talked about. I feel bad for our editor, Brianna for this one because there're so many show notes to create. Okay, shall we go on to our next question?

Cynthia Thurlow: Mm-hmm.

Melanie Avalon: We have a question from Kelly. The subject is "Cortisol." And Kelly says "Hi ladies, thanks for all that you do for the podcast. It has helped me and so many others. I've been listening since episode 3." Wow. "And look forward to the new podcast every week. I've been intermittent fasting for six months now and loving it. One side effect I've noticed is being easily startled in the afternoon before I break my fast. I sometimes have one cup of coffee early in the morning, but notice it on days that I don't have coffee too. Does this have to do with cortisol levels, can you speak to the effect of fasting on cortisol levels as a whole?" Thanks.

Cynthia Thurlow: Well, Kelly, there're many things that could impact how you're feeling and when we talk about coffee, quality is certainly important. Much a lot of crops, coffee is prone to exposure to mycotoxins or mold. When people sometimes feel differently on days that they're consuming coffee or not consuming coffee, I always think about contaminants. But obviously, if your body is dependent on the caffeine that could also explain why you are feeling like you're having a slump in the afternoon and yes, could that be mediated by cortisol, it could also be mediated by what you're breaking your fast with. So, there're many nuances here. Cortisol is definitely influencing many things that go on in the body, cortisol goes up in response to our circadian biology. And when we get up in the morning, that's when cortisol should be highest. it ebbs and flows throughout the day, and is lowest in the evening, except for our unicorn co-host, Melanie Avalon. But certainly, in me that's how you know, my energy is greatest in the morning and early afternoon, and then throughout the rest of the day, it's waxing and waning, but still fairly consistent. But you have to think about fasting as a hormetic stressor. If your body perceives it's too much stress, it can increase your cortisol in a non-beneficial way. And so, I think you really have to take into account many things when considering the net impact on fasting, it can be impacted by the foods you choose to consume, how's your sleep, what's your stress management style like? What kind of exercise are you doing? Where are you in your menstrual cycle? All of which can be impacted negatively or positively by when or how much fasting you are embracing? I think really sitting down and getting nuanced about how caffeine influences how you feel in the afternoon, you mentioned easily startled, yes, caffeine is a stimulant, so some people are slow metabolizers of coffee or caffeine and others are faster metabolizers of caffeine and so that can also play a role as well. But I think looking at it comprehensively getting a little bit nuanced and also understanding, not wanting to overfast because that can impact your cortisol, understanding where you're on your menstrual cycle and how is stress and sleep and nutrition impacting your cortisol as well? What do you think, Melanie?

Melanie Avalon: So, speaking to the fact that she has this startling effect if she has coffee or not. It sounds like she's having this wired feeling regardless of the caffeine. And it probably is related, I would guess, to fasting and being in that sympathetic state. So, the fasted state does upregulate hormones and neurotransmitters that are energetic and make you active, so norepinephrine, epinephrine, cortisol. Yes, that startling feeling, coffee or not that you experience with fasting definitely could be playing a role. As far as the effects of fasting on cortisol levels. We actually talked about this in a lot of detail on an episode where we were discussing a study, I think it's when we were talking about a blog post that Dr. Sarah Ballantyne had done on this, and she referenced a study looking at the effects of fasting on cortisol levels. And, actually, I think it was the effects of later eating--fasting with later eating on cortisol levels. And the fascinating thing about that study is I went and looked at it and it seemed that having a fasting window during the day with eating later, really did create the cortisol pattern that we'd want to see with the caveat of like Cynthia saying over fasting and having too much cortisol, but basically, our natural cortisol rhythm, we should get a bump in the morning with the dawn effect. And the purpose is to prep the body with fuel for the day, release glycogen from the liver, so you can get up and go and as a hunter-gatherer get up and go find your meal. It's normal to see a cortisol bump in the morning and then it should slowly taper throughout the day.

It seems that eating later can further stimulate that pattern where you have higher cortisol in the morning and lower cortisol at night. I think fasting can pair really well with cortisol levels. But again, you do want to be careful, Cynthia was saying that you're not going too much with it and releasing too much cortisol not being able to have a beneficial cortisol pattern. It's also interesting. I've interviewed Dr. Michael Breus on my show multiple times. He points out that most people should have these normal cortisol levels, but there's one chronotype-- one sleep chronotype that he calls the dolphin which I am and we're unique in that we naturally get a cortisol bump at night, regardless. I think that's actually a reason that I do so well with eating at night is because I can counter that cortisol bump and because when I eat my main, my big meal, I find that it really reduces my cortisol levels. Well, I don't measure them, but I'm assuming it does. That's the experience that I personally experience. And so that's one reason that I really like my fasting pattern for me personally with my cortisol levels. But yes, the startling it is, I can definitely see how fasting would be encouraging that response.

Cynthia Thurlow: Yeah, absolutely. And I think this is where that piece and bio-individuality really plays in. As an example, Melanie and I are recording this podcast at 5:45 PM, which means she's just getting revved up and my body is okay, we're going to be in bed in a couple of hours. And I think, really leaning into our physiology and doing a degree of experimentation to find out what supports your body. I know I have plenty of patients and clients that do better with tea as opposed to coffee in many ways, there can sometimes be less caffeine in some of the bitter teas. I would experiment to see how you respond to that. You can certainly, depending on where you are in your menstrual cycle, you may respond more readily and more easily to longer fast, shorter fast, etc.

Melanie Avalon: Yeah, that's a great suggestion. Yeah, a lot of people do well with the green tea and also a lot of people, I've seen people pair theanine with caffeine and find that it can mitigate some of that so that people can have a less stressful response to the caffeine. So that might be something to try.

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I left out the sweet potatoes and instead kept the salmon, the shallot, the cilantro, the pumpkin seeds, it was so delicious. They also have quite a few barramundi meals which is so exciting to me because barramundi is one of my favorite fish of all time. And Green Chef has an incredible offer for our audience, do not miss this. You can go to greenchef.com/ifpodcast and use the coupon code IFPODCAST to get $5.99 per meal on your first box and your first box ships free. Go to greenchef.com/ifpodcast and use code IFPODCAST to get $5.99 per meal on your first box and your first box ships free. Green Chef is the meal delivery service that you need and that I endorse. Do not miss this offer, Green Chef, the number one meal kit for eating well. And we'll put all this information in the show notes. All right, so we go on to our next question.

Cynthia Thurlow: Sure. This is from Lynn, subject is "Jetlag." "I love love, love your show. I'm working my way through your previous episodes. It really helped me the first couple of weeks of intermittent fasting to listen to your shows daily. I started on January 1, 2018 and I'm down 19 pounds and counting. I'm currently doing one meal a day. My question is regarding travel and eating to prevent jetlag. I heard about a study from some, can't remember which one, a university that to start eating a day before on the time of the place you're going to prevent jetlag. Have you ladies traveled far? And how do you do with jetlag? I'm in Hawaii to meet up with my husband who is stationed in Japan for two years. It's a quick trip. Intermittent fasting makes it easy when you're traveling for sure. I really struggled with jetlag yesterday, I also use melatonin and a homeopathic med to help. I still struggle with it. Even in Hawaii, I still want to eat at my scheduled time in Virginia. I am going to Japan this summer, who knows what or how I'll feel in Japan? Any thoughts on food, intermittent fasting, and jetlag? Thank you for all you do. You are an inspiration for all of us out there trying to make this work."

Melanie Avalon: Awesome, thank you, Lynn for your question. I used to travel internationally, I mean, relatively a lot, every year mostly. I haven't done that since I've started fasting. I've just traveled domestically, but I can still speak to it. And I'll be super curious to hear Cynthia's thoughts because she's traveling all the time, I feel internationally. There's been a really interesting study on jetlag and fasting specifically and how fasting can help basically mitigate the effects of jetlag. And the way the setup is, is rather than eating before, she's talking about starting with the way she's eating before traveling, they advocate just once you get to the new place it's fasting and then eating on the time zone of the new place once you get there. So, personally just traveling domestically, so obviously, the biggest difference would only be a three-hour difference. I found that I have zero issues. Whenever I travel between LA and East Coast regardless of which way I'm going, I just fast as I normally do, and then I eat my dinner in my new location. And it immediately sets me back to that wherever I am, I have zero issues, zero.

Our food and our circadian rhythm regarding our food intake can heavily influence our sleep circadian rhythm. Because if you think about it, you could be completely awake and then you could eat a massive meal and get really tired or you could be exhausted and fasted and hungry and not be able to fall asleep. There's a big effect on our food intake and our sleep. It could be a really nice hack to use fasting and then just eat on the time zone of we're going. But again, I haven't done this internationally. Cynthia, what are your thoughts?

Cynthia Thurlow: This is such a great question. Because I am a world traveler. This is one of my great joys in life is traveling. So gosh, in the past 18 months, we've been to Africa, we've been to Europe, I do a lot of West Coast travel. I do find for me I just get on the plane and I generally just fast and I stay hydrated. And then as soon as I arrived, so I try to get on the schedule of wherever I'm going. So, if I arrive in the morning, what typically happens when you arrive in Europe, you're arriving in there morning, I will try to stay fasted until lunchtime, which is generally when I break my fast. Obviously, when I've traveled to Africa, most recently, you arrive in the evening. And I typically-- if I'm hungry, I'll eat but if I'm not hungry, I'll just go to bed and then the next morning, I'll get up and I'll eat around the time I would at home, even though it's the middle of the night at home. But I think when you really look at the research, it takes about one day per hour of time difference. So usually, a solid week in Europe when it's six plus hours ahead and in Africa, I would imagine Japan is going to take a bit longer because that's more than 12 hours I believe ahead of the East Coast. But obviously, it depends on where your husband is stationed. I think that you can absolutely integrate fasting into helping support jetlag, I think staying really well hydrated and trying to get light exposure on your retinas is going to be important. The other thing I've learned is that I travel really well when I go East and I always struggle a bit more when I go West, I can actually travel more easily to Europe or Africa. And I struggle more when I go to California and I suspect it's because being ahead is easier than being behind.

So, my body at 8 o'clock at night is saying it's really late for me, "Don't laugh Melanie." 11 o'clock at night is late for me, but in my mind even though it's 8:00 PM pacific standard time my body is really struggling to stay awake. I think just understanding it's going to take a period of time, it could take up to two weeks, you may be actually in Japan for that amount of time, so it may take a bit of time to acclimate. And really just being open to the fact that you're going to have a couple of days where you're probably going to drag. But the one thing that I've learned that's been really helpful is staying hydrated, resting when I need to, and then making sure I'm eating the proper macros. Again, protein, vegetables work really well for me regardless of where I am, if I start eating a bunch of junk and I start drinking a lot of alcohol, which I don't do, that would definitely worsen the jetlag for me, so hopefully, that's helpful. And enjoy your time in Japan.

Melanie Avalon: It's so funny, that really speaks to the bio-individuality aspect because for me traveling from Atlanta to LA, I love it because it just gives me a longer fast, it basically adds on, I guess, three additional hours of fasting and I often think every night anyways, "Oh, I could fast for another three hours." So, it's my dream situation. I'm curious, did you have a different experience of jetlag and all of that before you were fasting?

Cynthia Thurlow: I have been, so this is our-- I say everyone has priorities and travel has always been hours. I struggled more with jetlag when I was in my 20s. By the time I got to my 30s, so obviously my 20s and 30s. I wasn't fasting. When I got into my 30s, I remember when we went to Greece for our honeymoon, I was miserable trying to stay awake. So, do I think that fasting probably has helped, potentially, I think I'm also much more aware of the net impact of lifestyle and how that plays in with jetlag. And, I probably walked around chronically dehydrated for years, which probably exacerbated my jetlag. So yeah, I can honestly tell you that I was that person who walked around feeling I was drunk for days. And it was because I just couldn't get over that sleep pump. And, obviously, I would say I've traveled pretty effortlessly since fasting, largely because I understand how to fuel my body. And I think that makes a big difference. And honestly, more often than not, when I'm in an airport or when I'm traveling even domestically, I generally will stay hydrated. I'll drink a lot of electrolytes, but I'll just fast in anticipation of wherever I'm going to. That's a good question.

Melanie Avalon: Fasting is such a wonderful hack and tool for travel I think and not having to deal with airplane food and not feeling chained to having to deal with the meal aspect of it. And yeah, I just find it so, so helpful.

Cynthia Thurlow: Absolutely, and I think it's interesting that one of the standard questions that I think we both get on social media is what do you do when you travel? So, I always travel with the if in need these are the things I'll eat, but I always travel with, Paleovalley beef jerky. I always travel with salted Macadamia nuts, because if I get in a position where I'm really hungry, I don't want to eat crap and most airports here in the US there's a lot of junk, I mean, occasionally you get unicorn airports but generally, there's just a lot of processed junk so, I always have that available if I need it. But it's easy just to stay hydrated. I mean I used to carry glass water bottles and depends on how much traveling I'm doing but now sometimes I'll just go in and buy, I know it's trying to find the happy medium of do I want to carry around a glass water bottle for four or five days or do I want to just buy a bottle of FIJI water and use some electrolytes in it and just forgive myself for the exposure to plastics and just be done with it.

Melanie Avalon: Yeah, goes back to deciding what's worth it and what's the cost-benefit and I will comment on the melatonin piece. I'm a huge fan of melatonin, I had concerns about it down-regulating melatonin production and whether or not I should take it nightly, but learning more about it, especially reading Dr. John Lieurance's book, I think he calls it Melatonin Miracle. I learned a lot about melatonin and realized it has a lot of antioxidant effects and people do high-dose melatonin supplementation and I've interviewed Dr. Kirk Parsley about this and he has a little bit of melatonin in his sleep remedy supplement which can be really, really amazing. Oh, by the way, I definitely recommend that supplement if you are looking for something to help you naturally fall asleep without pharmaceutical aids. We can get it at melanieavalon.com/sleepremedy and the coupon code MELANIEAVALON will get you 10% off. I think if I were to travel something where I had to just make myself fall asleep because of the timing issue, I would definitely probably do some high dosing of melatonin. I think Peter Attia has talked about this and I think he's more hesitant about melatonin, but he did say on a podcast I listened to recently that he will do the high-dose melatonin route to adjust to time zones.

Cynthia Thurlow: It's interesting, I interviewed Dr. Kyle Gillett, he is a functional medicine provider and we talked about melatonin because to me I use melatonin and it is a master antioxidant. Yes, it can help with sleep, but there are so many benefits and for people North of 40 in particular, many of them have very depleted amounts of melatonin in their bodies. And so, thinking of it from that perspective is very different. But he actually said in all of his patients North of 40 that he has not opposed to them utilizing supplemental melatonin. I think it can be helpful for those that are traveling. But I also think from the perspective of just aging in general. I do find for a lot of my patients and clients, they do very nicely if we do testing, and we confirm that their melatonin levels are pretty low, their urinary metabolites on the Dutch that using a titrated, meaning we go up and we come back down, we'll use a titrated approach to melatonin. I've had some pretty incredible results with utilizing that and I do have a very-- and maybe Melanie, I can talk about this on another podcast, I have a very stepwise approach to sleep support. And I'm very serious about my sleep, very serious about my sleep. So, there are definite products that I think can be very beneficial, melatonin can be one of them. I really personally like MD Logic's product. They're actually reformulating their melatonin, so it's going to be 100% clean, no rice flour or anything that. But that is probably my favorite melatonin to utilize and it's very potent. I can give the example that Designs for Health has a product called Melatonin SRT, sustained release. When I first tried the MD Logic product, I took the same amount except it was so much more potent the next morning when I woke up, I could barely open up my eyes. I remind people to go low and slow and the MD Logic product, which I know, both Melanie and I, both have codes, mine is CYNTHIA to give you 10% off, but melatonin is definitely a supplement that I think is really invaluable to use. And for those of us that are perimenopause or menopausal, it can be really very helpful for sleep support.

Melanie Avalon: Yeah, I'm so glad you brought that up. And especially with melatonin, that's one of the studies where they've done studies reviewing, I found one where they I think looked at 30. They looked at, I think 30 bottles of melatonin and it was around a dozen or 15 or so brands. And they tested for the actual amount of melatonin compared to what the bottle said and it was shocking. Shocking how far off they were. And this was mainstream brands. So, definitely finding a product that you really, so that MD Logic Melatonin definitely would be one to try. I think I shared this before but I think the thing that sold the deal for me-- I know I've shared this before. The thing that sold the deal for me about "Okay, it's okay I can be taking melatonin," is that night that I accidentally thought I was taking digestive enzymes and I was actually taking melatonin. They were in the same bottle and they look the exact same and I took, I don't even know how many milligrams I took. And I slept so well and because I didn't know I've had high dosed melatonin. I wonder if I would have felt groggy. How much of the placebo effect might have happened? I wonder if I would have felt it more if I realized, but I didn't realize until the next night that I had taken so much. And so, after that I was okay, it's fine, but melatonin.

Cynthia Thurlow: It's good stuff.

Melanie Avalon: All right, well, we'll put links to all of that in the show notes, which will be at ifpodcast.com/episode294. If you would to submit your own questions for the show you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can get all the stuff that we at ifpodcast.com/stuffwelike. And you can follow us on Instagram, we are @ifpodcast, I am @melanieavalon, Cynthia is @cynthia_thurlow_ and I think that is all the things. Anything from you Cynthia before we go?

Cynthia Thurlow: No, I think this has been a particularly enjoyable episode. Lots of good topics.

Melanie Avalon: I agree. So incredible and I'll let you go and wind down your day and I will talk to you next week.

Cynthia Thurlow: Sounds good.

Melanie Avalon: Bye.

Thank you so much for listening to The Intermittent Fasting Podcast. Please remember everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Nov 27

Episode 293: Holiday Feasting, Liquid Chlorophyll, Iron Supplementation, Anti-Inflammatory Foods, Sauna, Signs of Ketosis, And More!

Intermittent Fasting

Welcome to Episode 293 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

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Listener Q&A: Kasi - Liquid Chlorophyll during fast // Window Flexibility // Anti-Inflammatory Foods

The Melanie Avalon biohacking Podcast Episode #43 - Teri Cochrane

Episode 56: The Cochrane Method and Bioindividuality

Ep. 201-The Connection Between Genes, Detoxification, Hormones, and Immune Function

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The Melanie Avalon Biohacking Podcast Episode #149 - Chris Masterjohn

The Melanie Avalon Podcast Episode #61 - Dr. Cate Shanahan

BON CHARGE: Go To boncharge.com For A Black Friday Sale with a massive 25% off sitewide until 30th November!

Listener Q&A: Bruce - Thanks for all you do

Why Combine Sauna and Fasting

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Listener Q&A: Justine - signs of ketosis

Lumen, Biosense & CGMs: Carbs, Fat, Ketones & Blood Sugar (Melanie Avalon)

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TRANSCRIPT

Melanie Avalon: Welcome to Episode 293 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time and get ready for The Intermittent Fasting Podcast.

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If you recently saw a documentary on Netflix called Seaspiracy, you might be a little bit nervous about eating seafood. Now, I understand why ButcherBox makes it so, so clear and important about how they work with the seafood industry. Everything is checked for transparency, for quality, and for sustainable raising practices you want their seafood. The value is incredible, the average cost is actually less than $6 per meal and it's so easy. Everything ships directly to your door. I am a huge steak lover. Every time I go to a restaurant, I usually order the steak. Oh, my goodness, the ButcherBox steaks are amazing. I remember the first time I had one and I just thought, “This is honestly one of the best steaks I've ever had in my entire life.” On top of that, did you know that the fatty acid profile of grass-fed, grass-finished steaks is much healthier for you than conventional steaks? And their bacon, for example, is from pastured pork, and sugar and nitrate free. How hard is that to find? And ButcherBox has an incredible deal for our audience. For a limited time, you can get free grass-fed grass-finished ground beef for life in every box of your subscription plus $20 off, yes, new members can get free grass-fed grass-finished ground beef for life plus $20 off when you go to butcherbox.com/ifpodcast. That's butcherbox.com/ifpodcast for free grass-fed grass-finished ground beef for life plus $20 off and we'll put all this information in the show notes. 

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters which mess with your hormones, carcinogens linked to cancer, and obesogens which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years.

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means, when you put on some conventional lipstick, 30 years later, maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so, you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out. You can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well. 

And lastly, if you're thinking of making Clean Beauty and Safe Skincare, a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like the Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now back to the show.

Hi everybody and welcome. This is Episode number 293 of the Intermittent Fasting Podcast. I'm Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, Melanie, how are you?

Melanie Avalon: I'm good, I just checked when this is going to air. I wish I could ask you, how was your Thanksgiving but it has not happened as of right now. But I am super curious since this is the Intermittent Fasting Podcast. How do you tackle Thanksgiving with fasting?

Cynthia Thurlow: This year is a good example of--it's just the four of us, which I'm super excited about because it's really only the second holiday we've spent in our new home. I don't alter a whole lot to be honest with you, we eat earlier in the day, we usually eat by 3 or 4 o'clock. My teenagers will go back for seconds a few hours later, but I'm generally not hungry. I may have like a light meal to break my fast and then really lean into protein and veggies and that's one of the few times in the year I will enjoy pie like I make a really good apple pie. And there's something about even gluten-free crust that I love which is why I don't normally eat pie, but I will allow myself to enjoy and savor every single bite.

I think that I don't treat Thanksgiving any differently than really any other day because I don't alter the way I eat too much. And it's not to say that I can't, I just don't feel good when I eat certain types of foods. So, my kids get a lot of the starchy stuff like stuffing and potatoes and I'm the one that leans into like Brussel sprouts and other things that we might have alongside, the last couple of years we've been doing tenderloin and not turkey but ButcherBox very nicely sent me a lovely turkey. So, we will be having some turkey and some tenderloin for Thanksgiving.

But it's also the one holiday that my husband gets really into and wants to make everything himself. All these women listening, they're like, "Oh my gosh, I wish my husband would do that." He gets a little controlling about his kitchen on Thanksgiving, I really play an ancillary role on Thanksgiving and I'm completely fine with that because he's a really good cook. But it's sometimes an odd dynamic because I think we're kind of conditioned as a society that it's the woman in the kitchen all day long. And actually, it's my husband like up early for the bird and he's all about making the stuffing. And every year he perfects his stuffing and he makes this is horrible, Chex Mix. And so, Chex Mix is like a crack in our house, my husband and my kids will eat it till it is gone. But I jokingly tell them, they need a feed bag just to put the strap on over the back of their neck and just let them eat it all day long, and they could not be happier. There's a lot of feasting in our house. It's usually a pretty relaxed day. How about you?

Melanie Avalon: Similar to you, I personally don't really adjust much. Because doing my one-meal-a-day approach that I do. I literally am feasting already every single day. And, for example, it was my birthday this week, and a friend came in town and we went to dinner. And I got two entrees. It was because I wanted to-- I couldn't decide, I wanted both steak and fish, so he was like just get both. But I was like, "Okay, I'll have like a bite of the steak and eat the fish, but I ate all of it." [laughs] which was fabulous. And that's an addition to the appetizers and all of that. But the point being is, I am so accustomed to eating large amounts of meat at night and protein, so on Thanksgiving nothing really changes much because the foods I want to eat what you were saying about, the foods that make you feel good and the foods that don't, I would like to eat a lot of other different foods that would also taste good, but they would also make me feel not so well. Or I can eat the foods that taste just as good to me but make me feel great. On Thanksgiving, I would still do my one-meal-a-day type thing and just eat a ton of Turkey as my meat.

Cynthia Thurlow: And I think it's interesting because for me personally, this is what my life has evolved into. And I'm completely happy in the space. But I do know, when we have like family or friend's events, people always kind of look at me and they're like, "Well, you're not going to have this and you're not going to have that? And I'm like, "No, because I actually don't feel good when I eat X or Y. And I'm totally fine with you eating X or Y. It's just not what I'm leaning into. I think it's also like being respectful. Sometimes it can be very triggering when people see you eat a particular way, then I always say there's no judgment, I just know that I'm at a stage in my life where it's not worth it for me to eat foods that make me feel badly. Like if I were to have a couple of glasses of wine, guess what my sleep is going to be terrible. I'm going to get hot sweats, night sweats, and I'm going to wake up in the morning and my Oura Ring is going to be barking at me.

From my perspective, it's a cost-benefit, like what makes me feel good, what allows me to wake up on the day after Thanksgiving, and whether we're doing a 5k, we try to do things that are active, and you're asking what the prevailing strategy is, move my body, try to lift if not on Thanksgiving, the day before or the day after, stay really well hydrated, and then choose the things that you want to splurge on and typically mine is apple pie. [laughs] I love apple pie, I love apples in general. But I love, I make a really good apple pie. It's very basic, but it's really good, and my kids laugh because I'll stand there at the counter, and I'm just eating the crust. Like I wouldn't normally eat crust I am like, "Oh, this is good."

Melanie Avalon: Yeah, one of the things I really like about fasting though, in general, with the holidays, like before fasting, I would have a lot of fear. I would love the holidays and I would love the food, but I would have a lot of dread or concern about overeating, weight gain, overindulging, and it was this weird blend of the pure excitement and joy of the food and also dreading the aftermath. And now I never really experience that, like holidays I just genuinely look forward to the whole food experience with minimal, I mean really honestly, no negative effects.

Cynthia Thurlow: Yeah, I mean, to me, especially because I have teenagers and I recognize that time is fleeting with them. I've always loved our nuclear family and prior to the pandemic, we always spent holidays with our extended family. And now things have changed a little bit and that's okay. But for me, it's really the joy of having conversations with my kids because as teenagers they spend a lot of time connecting with their friends or disconnecting from their parents. And so, for me we get into these discussions of "Are we going to do like a Harry Potter marathon, are we going to do Lord of the Rings, which that usually sends my kids into orbit?" Trying to find ways that we can connect after eating, "Are we going to play football or am I going to watch them play football?" By just finding things that we can do to connect together that don't per se disconnect us more, because I think it's very easy in our culture to be around other humans but be so disconnected like people that are on their phones constantly. And I'm certainly not perfect. I'm not by any means am I suggesting that, but I really try on holidays to be very connected and very present. And that to me is something I'm much more cognizant of now than maybe I was 10 years ago with my kids.

Melanie Avalon: Have you ever used one of those phone jail things?

Cynthia Thurlow: Not per se, although the other day, interestingly enough, my 15-year-old who is my more challenging child I will say, came home from some team practice. I know his blood sugar was low because he was hangry, he was just really grumpy. I had asked him to help take the dogs out and I got a rash of reaction to that. And because he was so disrespectful, I just said, "Well, I have your phone, and so I hid his phone for two days." So yes, we do have phone jail but said child is pretty clever and so he found his phone in the midst of phone jail and took it. And then he got another day added on to not having a phone. So, yes, we do Institute phone jail but not per se at the table. Usually, phone jail is when an infraction has been incurred and I'm trying to think of what will hurt him the most, [laughter] what is going to be the most unpleasant punishment I can give him. I'll just take your phone, and he feels like he's lost an appendage.

Melanie Avalon: I was going to talk about one other thing, but instead I'll save it for next week. And instead, I have to comment on the phone. When I was driving to dinner--Has your phone SIM card ever decided it's not there? Like your phone is like "can't find SIM card?"

Cynthia Thurlow: No.

Melanie Avalon: Oh, my goodness. It's crazy. Basically, your phone loses all capability, it can't be a phone, it can't make calls, it can't find the internet, and I was driving and I just realized how dependent we are on our phones because I was all dressed up and had all my stuff. And I was halfway to Midtown Atlanta. And my phone was not getting the internet. And I was like, "I don't know how to find this hotel." I don't know how to get there [laughs]. I was like what am I going to do? Pull off to a gas station and be like, how do I get to [laughs] Four Seasons, it was crazy, it made me realize just how reliant we are and then I just felt so useless that I was not going to be able to navigate, somewhere where I had gone before multiple times.

Cynthia Thurlow: I will just interject that. My mom lives in a rural part of Maryland on a beautiful lake and when I was coming back most recently, the way that I come from Western Maryland to get back to Virginia, I have to go through West Virginia for a brief scooch amount of time. Well, I went from having ways to having no ways, and then not knowing where I was because I had only gone this route once before. And at one point, I was driving for an hour with no ways, no Wi-Fi, no nothing.

Melanie Avalon: Did you feel naked? I felt so naked. "Oh, I felt naked."

Cynthia Thurlow: Yeah, I was like contemplating how do I find a police station and talk to them about the fact that I didn't think to print out directions because why would I have needed them? You start to realize how dependent we are on technology for sure.

Melanie Avalon: It's the craziest feeling and I was like, "Oh, this is what it was like back in the day." I bet people were a lot better with keeping appointments. Because if you don't show up, I was like "They're going to think I'm dead."

Cynthia Thurlow: No, I was explaining to my kids, we used to have MapQuest or we used to have these little Garmin's in our cars, and you would update them periodically, and my kids were like, what? And I was like, "Yes, you had to print things out or write them out." I was like, "That's how old school mom and dad are?

Melanie Avalon: When I was growing up had to print out from MapQuest. So good times.

Cynthia Thurlow: I'm glad to know you recall MapQuest.

Melanie Avalon: I was right on the cusp.

Cynthia Thurlow: Yeah. We represent many generations on this podcast.

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Melanie Avalon: Would you like to jump into everything for today?

Cynthia Thurlow: Absolutely.

Melanie Avalon: To start things off, we have some questions actually four questions that we can do rapid fire and they are from Casey. The subject is "Liquid chlorophyll during the fast, window flexibility, anti-inflammatory foods." And Casey says, "I have a few questions shared here." Number one, can I consume liquid chlorophyll in my water while in a fasted state or is this a no, no?"

Cynthia Thurlow: Yeah, well, I mean it's a plant. I think it depends on how it's processed because chlorophyll does not taste good and most chlorophyll that I have used with patients has some sugar, dextrose, etc., in it to make it palatable. In most instances, if you're looking at an ingredient list, it very likely has sweeteners in it and therefore I would not recommend that for a clean fast. Do you have an opinion?

Melanie Avalon: Yeah, especially after interviewing. I know you are friends with Teri Cochrane, she's wonderful. She wrote a book called, is it Wildatarian?

Cynthia Thurlow: Wildatarian? Yep.

Melanie Avalon:  I had her on The Melanie Avalon Biohacking Podcast. You've probably had her on your show as well, I'm guessing?

Cynthia Thurlow: I have, twice.

Melanie Avalon: Yes. She has fascinating thoughts on chlorophyll supplementation. I searched high and low to find a chlorophyll-- like a liquid chlorophyll supplement that didn't have lot of additives. The closest I could find was, it's mostly pure chlorophyll but has glycerin. It doesn't taste sweet. It tastes very grassy actually. But to be on the safe side, I would always just kind of have it to open my window. The chlorophyll itself is not a problem. But like Cynthia said, it's hard to find-- maybe I should make a chlorophyll. "Oh, my goodness." Okay, friends, stay tuned. I do think it's really wonderful. I would err on the side of keeping it in your eating window unless you can find a pure version, which, good luck.

Cynthia Thurlow: It's hard to find and it doesn't taste good. That's actually why oftentimes it is sweetened. I oftentimes will recommend chlorophyll for constipation.

Melanie Avalon: Hmm, nice. Teri recommends it for actually iron levels.

Cynthia Thurlow: Yes, I love Teri. I've had her on the podcast twice. And she always brings such a unique lens to looking at health and wellness, really a unique lens, like the Cochrane Method is her trademarked method and I've learned so much through her.

Melanie Avalon: She's really wonderful. Because she's the one who talks about the amyloid formation in conventional agriculture. I bring this up every time I interview somebody in the-- I don't know what words to use, I just brought it up the other day, interviewing the founders of regenerative pastures, which is kind of like a ButcherBox system, but they're US based only and they have a lot of really amazing options. But actually, that interview was amazing, but anytime I've interviewed somebody where we're talking about like conventional agriculture versus regenerative and holistic, I bring up Teri's theory, which basically is that the stress levels of the raising conditions create these truncated proteins and conventional meat that has a very inflammatory potential, which nobody else is talking about. So, I find that very cool.

Cynthia Thurlow: Yeah, and she's not a big fan of chicken and a few other things, but chicken is, I think the basis of a lot of people's diets, and by no means am I telling everyone to panic and stop eating chicken. But just to give it some pause and think that has a lot to do with her desire to encourage people to eat more wildatarian proteins, she certainly has had a huge influence on us. We got very creative during the pandemic.

Melanie Avalon: She's amazing. Okay, so much for rapid fire. Casey's, second question, she has some questions about supplements taken in the fasted state or during the eating window. We can just go through these, D3, B12, iron, so D3?

Cynthia Thurlow: Fat-soluble vitamins, vitamins A, D, E, and K, I generally recommend that you take with a meal so that they can slow the absorption, B12 provided that it's clean. That to me is benign. Iron, I generally like people to take with food for a variety of reasons. But I understand why people ask these questions because they are trying to simplify their lives, but I would say iron and D3 taken in a fed state, B12 or B vitamins I think are fine provided that they're clean taken in a non-fed state. What do you think?

Melanie Avalon: Agreed, the only caveat I would provide B12 similar to chlorophyll, it is water soluble, so it can be taken completely fasted but it can also be hard to find versions without the additives, they're usually always flavored, and also with B12, it can be really important, especially given your MTHFR status to get a properly methylated form, so Methylcobalamin version. And then my iron caveat would be-- and I struggle with iron regulation, really bad, I just don't seem to make ferritin, I do but there's just some issue there with my conversion, I think. I am very in tune with iron supplementation. I personally will use desiccated spleen as well as kidney which has some iron, I use ancestral supplements, I do have a code for them. If you go to melanieavalon.com/ancestral, the code AVALON10 will get you 10% off. I take their kidney every night, I take their spleen a few times a week and I take that with food. I don't take the spleen every day because I found-- researched this and I've talked with my hematologist about it. If you take iron supplements constantly trying to up your iron level, your iron actually has an iron regulation system where it downregulates its absorption if you're taking in a lot consistently. On the contrary, if you're not taking a lot, it will upregulate its iron absorption. It can be nice to do a punctuated approach.

Another option is chelated Iron because iron can be very constipating. I love Elle Russ-- I'm actually having her on my show for the third time coming up soon and I was just recently on her show The Elle Russ Show. She is very in tune with iron supplementation because it can really relate to thyroid issues. And she's a big fan of Chelated Iron by Bluebonnet and that has to be taken on an empty stomach. The reviews for that are very, very positive for people saying they are able to raise their iron and don't get constipated. So, that's another option, but that would be on an empty stomach.

Cynthia Thurlow: Yeah, the Chelated Iron is really key. I think for many years I was on Chelated Iron and there's nothing worse than being put on iron. And then if you're not constipated, then all of a sudden you can't go to the bathroom. So, Chelated Iron tends to be much easier on the gut. And I would agree with you that anemia in general and low ferritin levels, low iron levels can be very confounding. And it's not at all uncommon for women really at any stage of life to have issues surrounding this, so a commonly recommended supplement.

Melanie Avalon: Yeah, the iron issues are one of the banes of my existence? I'm really excited actually because I'm going to be interviewing Morley Robbins for his book, Cu-RE Your Fatigue, The Root Cause and How To Fix it On Your Own. And apparently, it's mostly about iron regulation. I'm excited to see what I learn about that.

Cynthia Thurlow: Yeah, it's interesting, your podcast about glutathione came out today. And I was like, "Oh," I'm knee-deep in podcast prep for two podcasts next week. But I was like, I really need to listen to that.

Melanie Avalon: Oh, it's so good. I was on the fence about glutathione IVs and glutathione pushes. Now I'm fairly convinced they're a waste. It's just in and out of your body and it doesn't even get absorbed really. I don't know if he's a doctor, I think he's just a researcher and a pharmacist, not just? But I think he's a researcher and a pharmacist. He wrote a book called The Glutathione Revolution. He does have his own proprietary topical glutathione where they have studies showing how it is absorbed in the half-life in the body. I've been using that every single day and night since reading the book and interviewing him, I'm sold. I think glutathione is so important, supporting it naturally, and then if you supplement using his version, I feel like I'm just giving all the codes. But his version that I've been using is melanieavalon.com/auro A-U-R-O is his brand, and then the code MELANIEAVALON should get you a discount.

Cynthia Thurlow: Yeah, it's interesting because Teri Cochrane is not a fan of IV pushes or IV glutathione drips. As we keep plugging Teri Cochrane that's definitely really aligned with my conversations I've had with her. But I'll definitely have to dive into that podcast.

Melanie Avalon: Let me know what you think. I think I wanted to believe it, because, you want to think, "Oh, I can get some glutathione IVs or pushes and do some good," but it's really like I said, in and out. And then after reading it, I reached out to my friend James Clement, he wrote a book called The Switch, and he's a dear friend. And I really, really respect him. And I really feel like I can always get a very unbiased perspective because he does have a book, but he's not selling anything. He runs a lab that studies longevity. I asked him and he's like, yeah, there's no point in taking glutathione, it was when I was actually feeling really sick. And I was texting him. I was like, "What do I do? Try to get NAD." I was like, "I'm going to go get glutathione" and he's like, "Don't get the glutathione, it's not going to help." So, tangents.

Okay, and then another question from Casey, she said, "She's considering a window of 12 to 8 o'clock, but she feels on a Saturday or weekend that she might need more flexibility due to long runs or social engagements." So you have recommendations on timing to make the weekends work?

Cynthia Thurlow: One of the key aspects of intermittent fasting is flexibility. I'd really encourage you to experiment, maybe you're going to have a wider feeding window on a weekend, maybe you'll have a shorter fasting window on a weekend. I think that the key is really kind of leaning into what makes the most sense for you. I know that pre-pandemic I definitely was much more flexible in the weekends, because we were oftentimes going out or had events, and I couldn't per se time when I was eating or when I wasn't eating, it was oftentimes dependent on other people's schedules. I would say experiment to see what feels good, maybe if you're doing longer runs, you're going to want to break your fast earlier. Maybe if you're going out to dinner, you are going to have a wider feeding window. And that's completely fine and I do encourage people to change up what they're doing. Our bodies get very accustomed to eating the same foods, having the same fasting windows. And so, I do like variety. How about you? Do you have any different ways of doing things on the weekend?

Melanie Avalon: Well, first of all, I love your answer. And that's the answer is basically going to suggest which is just-- I think it's actually-- Especially if you have a regimented window during the week, it's a great time to have some flexibility, and actually, you said change things up, keep your body guessing. Well, I do a completely different window. If I was doing her window, I probably would adjust it a little bit where I might just open it a little bit later and keep it open later. Assuming that you're having social engagements at night dinners, things like that. For me personally, I really honestly do the same window every single night. I don't need to adjust because it literally fits in almost every situation.

The only time it wouldn't fit would be if I had to go to an early dinner. And then honestly, I probably just wouldn't eat. If there's one thing I won't do, I don't eat if I'm not hungry, I don't eat just to be social, I don't enjoy it. So, if that's the case, I usually would just drink and then eat later which interestingly, another tangent, this might be controversial, but they'll often say to have alcohol with food to slow the absorption and have a better effect on your body. I find the only time I'm really drinking with food is when I am having dinner out because normally, I drink before eating. And I find that I do a lot better that way drinking before because I feel like my body processes the alcohol completely and then it's not impeding or competing with the dinner. And I find when I have wine with food, I feel like the alcohol lasts longer in my system. So, just a random thought.

Cynthia Thurlow: Yeah, I'm definitely one of those people that I had to drink with food because if I didn't, I would feel the effects pretty strongly. [laughs] I would be the person who would be like, "Uh-oh," I don't feel so great.

Melanie Avalon: Actually, maybe that's why I like it more not because I like feeling crazy, I can drink less and have the drinking experience compared to if I'm having it with food, I would maybe drink more.

Cynthia Thurlow: You know, what's interesting is that I always assumed that because I was the type of person, I could never really drink a lot. What's unique about my body, I don't make enough alcohol dehydrogenase to break this down properly or are my detoxification pathways just not optimized? I mean those are the things I used to spend time thinking about. [laughs]

Melanie Avalon: I've done my genetic data and one of the systems that I ran it through, I know I've said this on the podcast before, but I don't know if I've said it when I was with you. It basically looked at your, "Oh, I think it was the SelfDecode report. It was the food one," and it showed you like all these different food options, like carbs, I don't know, there was like four food-related things, and there was alcohol, I was bad with everything food related and great with alcohol. Alcohol was like green and then everything else food related was like red, red, red. [laughs]

Cynthia Thurlow: Well, it's interesting because I did do genetic testing over the summer with Kristina Hess and that's an area of nutrigenomics, that's her area of expertise. Things that were consistent, and validating were things like, "Do you like lean meat or fatty meat?" I was like, "Oh, lean meat all the way. I don't feel good when I eat fatty meat." And we were going through the report and she was like, "I can see where that is, I can see where you're very athletic, I can see that you're someone that actually would tolerate a little bit of dairy, you can actually tolerate a little bit of alcohol." And I was like, "That's interesting," because it hasn't been my own experience. But we can't consider the fact that or we need to consider why bio-individuality is such an important aspect of whether we're leading into this next question talking about inflammatory foods. For each one of us that could look very different and I know I don't think I ever perceived the foods I no longer consume now were bothersome even 15 or 20 years ago. And so, just understanding that there's the genetics piece plus exposure piece, and they can all play a role in how we feel when we eat certain foods.

Melanie Avalon: I think that's so key and speaking to that it's so interesting when you do pay more attention and "Clean up what you're eating," how you do notice, "Well, I don't really eat foods that bother me now." But if I were too, I really notice and I just look back at my old self and I think about everything that I was eating and how I didn't even notice because I think it was an overall systemic inflammation. So, you didn't really pick up on any one signal from food. But yeah, so Casey's last question which you hinted at. She says, "What are some of your top anti-inflammatory foods? What are the foods you'd recommend avoiding that are most inflammatory?"

Cynthia Thurlow: When I think about top anti-inflammatory foods, I really think about phytonutrient dense foods. When you hear the term eat the rainbow, I think about green leafy vegetables, I think about berries, especially blueberries, raspberries, blackberries. I think a great deal about medicinal mushrooms, and no I'm not talking about mushrooms that are psychedelic. I think about curcumin which is a component of turmeric. I think a great deal about polyphenols that you get in green tea and bitter teas and black coffee, preferably mold-free. The most inflammatory foods in my estimation are seed oils and highly processed hyperpalatable foods, gluten, dairy, in particular people that are susceptible to that, sometimes grains, processed sugars, alcohol, soy, so it really depends, just like Melanie was saying she feels differently when she has alcohol on an empty stomach versus in a fed state. Bio-individuality but seed oils are the most inflammatory foods worth eliminating if you do nothing else. Read labels, ask when you go to restaurants, I think seed oils down to a cellular level the most damaging food like substances that most of us consume unknowingly in many ways. How about you?

Melanie Avalon: Yeah, we have very similar lists. So actually, my big one for anti-inflammatory isn't so much a specific food as it is an approach to the amino acid profiles of foods. In particular, because there are nine essential amino acids and some of those are more growth-promoting and can be inflammatory in high amounts, particularly things like methionine, which is really high in muscle meats, compared to "more anti-inflammatory amino acids," things like glycine. So, fish, for example, tends to be a more and I'm using quotes because inflammation itself is so complicated and nuanced and in a way, it's hard to really deconstruct what is inflammatory and what's anti-inflammatory, but in general, the amino acid profile of fish tends to be a "more anti-inflammatory amino acid profile" than something like muscle meat and then the amino acid profile of more gelatinous cuts of red meat tend to be more anti-inflammatory. That is actually a large reason that I make shellfish and fish basically the foundation of my protein, it's the reason I eat so many scallops because I read this one study that looked at the inflammatory potential, I think it looked at like liver enzymes or the effect on the liver in particular and it looked at chicken, cod which is fish, scallops and then one more, I'll have to find the study and put this in the show notes. But the effect of scallops, like the anti-inflammatory potential was insane. After I read that I'm eating scallops all the time.

Cynthia Thurlow: You want to know, it's one of the few foods my husband hates. So like, "I can only really eat scallops when I'm in restaurants because he dislikes them that much, but I actually really enjoy them."

Melanie Avalon: Oh, I love those scallops as you guys know. Yeah, having scallops, for example, would be a pretty anti-inflammatory protein. And then it's not just the amino acids as a benefit of fish, also the omega-3, omega-6 ratio. And this is another thing where it's not so much take omega-3 because it's anti-inflammatory, I think what's more important is the ratio of omega-3 to omega-6 because we need both. And we just want the ratio to be more in favor of the omega-3 side. I've seen different amounts when they say hunter-gatherers ate omega-3 to omega-6 ratio of between 1:1 to I think between 4:1, which, sorry omega-3 to omega-6, yes, 4:1, or wait it'd be another way around? Probably the other way around. In any case, today, the ratio tends to be I think it can be like 20 or 30:1, it's crazy.

And again, a lot of people will go the route of like, "Oh, well, high dose the fish oil, eat all the salmon." I think it's more about the ratio, I don't think we necessarily need a huge amount of these omega-3s and omega-6s in our diets, but we want that ratio to be more ant-inflammatory than inflammatory. Although if you want a really nuanced conversation on this, which is going to add a lot of caveats, listen to my interview with Chris Masterjohn, because we dive deep into this and he actually has a much more complicated view, which contradicts a little bit about what I said, but it still stands that the omega-3 to omega-6 ratio I think is important.

And then on top of that some things that Cynthia mentioned, a lot of spices can be really anti-inflammatory. She mentioned curcumin that's found in turmeric, I eat so much turmeric every single night. I eat a lot of ginger.

Cynthia Thurlow: I love ginger.

Melanie Avalon: I love ginger, I love turmeric and ginger. They are the two "spices" because I know ginger is a root. I just gravitate towards them like none other and then they always come up in the list of the go-to anti-inflammatory spices. I like to high dose those, ate a lot of that. Everybody knows I went through my pineapple phase. Pineapple can be really anti-inflammatory because of the bromelain, which is a proteolytic enzyme that breaks down proteins, kind of like serrapeptase except serrapeptase, you're taking in a fasted state and pineapple is a food and can help with digesting your food. The main reason I want to get back to pineapple and the reason I haven't is for some reason intuitively, it just feels too sweet to me now, but when I was eating that the reductions in inflammations I just saw personally in myself were amazing. And then for the inflammatory side of things, trans fats, yes, they've been banned, but they are still there, seed oils, that's what I had written down for sure like Cynthia was saying I do think that is huge, especially the processed ones, the refined seed oils, and they're just rampant. I think Cate Shanahan, her book, The Fatburn Fix talks a lot about this, and there's like the three S's, canola, corn, cottonseed, safflower, soy, sesame?

Cynthia Thurlow: Sunflower.

Melanie Avalon: Sunflower. Yeah, so definitely looking for those. Gluten, I think can be very inflammatory for a lot of people. Those were the three main ones I wrote down and then just in general, I think the most inflammatory thing, well "processed foods," just processed foods, and then just eating too much like the energy toxicity of overindulging can have a very inflammatory effect compared to a calorie-restricted diet or fasting, which ultimately tends to create calorie restriction or allows for that fasting time can be anti-inflammatory. But the eating process is inflammatory just by its nature.

Cynthia Thurlow: It's all good.

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Shall we go on to Bruce's question?

Cynthia Thurlow: Yes, this is the subject, "Thanks for all you do. I recently listened to all of the episodes on your podcast, and I would like to thank both of you for your dedicated work. I'm wondering if you've seen anything on sauna sessions and fasting. I have a sauna that I built a few years ago and use it four times a week. I have recently started using the red lights that are part of the lighting system that came with the heater control package because Melanie saying red lights were beneficial. Love Bruce." I cannot think of a more Melaniesque appropriate question."

Melanie Avalon: Bruce, thank you so much for your question. I do love the red lights, so I'm glad you're on that board as well as the sauna. I googled sauna and fasting and I didn't really find any studies per se. But I can speak to my personal experience and I found a very wonderful blog post written by Siim Land who I've had on my show twice.

Cynthia Thurlow: Me too, he's awesome.

Melanie Avalon: He's wonderful. Although I was thinking, I feel like he hasn't been posting. I feel like I haven't seen much from him recently.

Cynthia Thurlow: Yeah, he's been quieter. I don't know, he might be writing a book. He's like a proliferative writer.

Melanie Avalon: He's just so smart.

Cynthia Thurlow: Mm-hmm and he doesn't have-- one of those things for me, I really am oftentimes fascinated/humbled when people that don't have traditional research or medical training are just able to grasp such complicated concepts, much like you Melanie, you can grasp such complicated subjects and really understand it at a level that even for myself, sometimes I'm like, "Wow, I had never thought about that." So, he's one of those young protegees of the science community.

Melanie Avalon: Well, first of all, thank you for saying that. And yeah, he's younger than me.

Cynthia Thurlow: I guess he's like, 25. [laughs] He's a young buck.

Melanie Avalon: I'm thinking maybe because he is so young maybe he had some life development career-wise.

Cynthia Thurlow: No, I think he's just smart and curious snd I think that has served him well.

Melanie Avalon: Yeah. I know he's amazing. I found a blog post by him called Why Combine Sauna and Fasting. I'll put a link to that in the show notes. But I will give you the takeaways from that blog post. This is all the work of Siim Land, not myself. But he makes the case that both sauna and fasting have a lot of similar benefits as far as anti-aging, longevity, and supporting the immune system. And sauna has some benefits that fasting does not automatically provide. For example, the cardiovascular workout equivalent of a sauna session, you're not going to get that from fasting. And then on the flipside, I guess you could say there are things that fasting would provide that sauna wouldn't necessarily. 

But he says that they work really well symbiotically for something that, I would have never come up with this and I don't think I would have ever come up with this. But he talks about the importance of autophagy in both fasting and sauna, so both sauna sessions and fasting instigate autophagy, which is basically a cellular cleanup process in the body. It's really linked to longevity, anti-aging, disease prevention, so many things. What's interesting is one of the main benefits of sauna comes from heat shock proteins that are activated when you do a sauna session. And there are some studies on heat shock proteins in rodents and they found that the autophagy process is actually required to experience the benefit from the heat shock proteins. And the autophagy in part possibly mitigates some of the actual stress or the detrimental effects of heat shock proteins. It's possible that by really ramping up your autophagy, which would happen with a fasted state that you will get more benefits from the sauna, and you'll get a more-- to use that word anti-inflammatory response, you're going to get the benefits either way, and it's not something to be worried about. But basically, the fasting during the sauna session, he said, it's basically like better quality control when your body is doing that cleanup process and inactivation with the heat shock proteins, keeping the healthy cells and getting rid of the negative cells.

And then something else, I actually did think about this, he mentioned this, but I think I would have thought about this too. He talks about how both fasting and sauna increase human growth hormone. And he thinks doing sauna while fasting can further increase that human growth hormone and mitigate any potential catabolic effects of fasting. The reason I think I would have thought about that was because I interviewed Wendy Myers recently, she pointed out something in her book that blew my mind. I read it. I don't know if I mentioned this on the show already. I read it, I was like, "Oh, that can't be." I was like because somebody would have told me that, I actually didn't believe it. And then I went to find a study and it's true. Did you know, in order to release human growth hormone from exercise, it's from the heat created from the exercise, like it requires heat.

Cynthia Thurlow: Interesting. I guess that's why it's important to sweat and raise that core temperature.

Melanie Avalon: Yeah, that blew my mind. I was like, "No, surely exercise releases human growth hormone by some other mechanism." But no, it actually requires heat, if you're like working out, and you never raise your core body temperature, you actually might not be getting some of the benefits.

Cynthia Thurlow: It's interesting because I do Pilates every week and this morning it was a different type format of Pilates, and it's not my favorite. And I was laughing with the instructor who I love. I just take her classes because she really challenges me. And I was laughing and saying, "Okay, it takes me about five minutes of doing Pilates, we're lifting or whatever I'm doing to warm up enough that I take off whatever shirt I have on." And I was saying to her what we were doing this morning was so much more intense that within like two minutes I was sweating. And so, I think it makes sense and you have to exert yourself hard enough because we're really looking for some degree of hormesis. We want a beneficial stressor to the body, so that would make sense although I don't think I've per se thought about it that way before.

Melanie Avalon: Yeah, it really blew my mind. But yeah, that word hormesis. I think basically the case that Siim Land makes with a sauna is that you will get a more beneficial hormetic response from sauna use if you're fasting during it. And then I just know for me personally that you could not pay me to go in a sauna with food in me, that experience feels very unpleasant. Because there's something about like the detox and the sweating and letting it all out like to be digesting food and to have all of that and yet at the same time would just feel like "Oof," it would feel " Oof." It'd just not feel good. I do have a sauna recommendation if people would like a recommendation. I personally use the Sunlighten Solo unit every single night of my life. I cannot even express my obsession with this creation. I would love to have a cabin unit which Sunlighten also makes cabin units. But I live in an apartment that's not going to happen and their solo unit is this really cool contraption that you actually lay down inside of. It's kind of like, I don't want to say a coffin, it's a dome.

Cynthia Thurlow: It does not look like a coffin. [laughs]

Melanie Avalon: It does not, it looks like, I don't even know how to describe it. And it lights up, it has chromotherapy lights. And what's really wonderful about it, especially for me is your head is outside of it. I attach-- I've come up with this whole-- You can get one of those bendy arms that holds your phone and I attach that too because I put the solo unit on top of a twin frame, metal frame from Amazon that I got, so I can put a link to that in the show notes. I attach an arm and then it holds my phone over me so I can lay in there, my head is out of it, and I can read my books, and do my research, and do emails and it's just the most wonderful experience. They also have their products tested for EMF which is amazing. I recommend that solo unit. I also recommend obviously they're cabin units if you do have the space for that as well. If you tell them I sent you, they will give you a really good discount. That's at Sunlighten. But, Cynthia, do you have a sauna?

Cynthia Thurlow: We do not yet and that has something to do with the fact that we are putting a pool in next year and we're going to create an exterior structure. And I am envisioning that the exterior structure will have our infrared sauna in it, as opposed to it would have to reside in our garage. Even though the Sunlighten people have assured me it's completely fine. The area of the country I live in is very humid in the summer. And the thought of [laughs] being in a steaming garage with an infrared sauna is not really of interest to me. Right now, I have a sauna blanket. And yes, I'm working with the fact this is a temporary solution by HigherDOSE and so it's a sauna blanket that you get inside of and you sweat like crazy. And then I get on my PEMF mat, and I'm just so happy, I cannot tell you how much I enjoy the PEMF mat, I fall asleep on it, it's so relaxing, there are different settings, I have no affiliation with HigherDOSE, I just recommend that mat to everyone. But if you are space-constrained, Sunlighten makes apartment and small space-appropriate options as well as HigherDOSE, coming from a very large house that we had in Northern Virginia with a very large basement to a slightly smaller house with no basement has meant that we've had to get very creative. So, when that exterior structure is created, I'm excited because it's going to have like a little gym area inside that I can work out in.

Melanie Avalon: It's very exciting. Yeah, I can't wait for you to get the experience that you were sharing about just how good PEMF makes you feel. That's the way I feel after my sauna session each night.

Cynthia Thurlow: And I think it's important to find things that make you feel good. For me, I fell asleep on it every night this week, and I was like, Okay, "I cannot fall asleep on it because and I can't fall asleep in my normal time." So, now I have to do shorter episodes because you can change the settings and certain settings are impacting you more for relaxation and pre-sleep mode versus stimulating. And there's nothing better than lying on this warm mat. It's just glorious. Makes me feel so good.

Melanie Avalon: It's amazing. All right, shall we answer one more question?

Cynthia Thurlow: Sure.

Melanie Avalon: We have one last question; this is from Justine. And Justine says, "Hi guys, love the podcast, I've been listening at work, and I feel like I've learned a lot already. I'm relatively new to intermittent fasting, but I've had a good experience and results so far. You've talked previously about the science you feel when you are in ketosis, metallic taste in the mouth increased or different energy. Could you go over the signs to look for as a new intermittent faster, I am anxiously awaiting a sign that I am in ketosis but I'm not sure what to look for. Thanks, from Ottawa, Canada."

Cynthia Thurlow: Well, Justine, welcome to the intermittent fasting world. Typically, when patients or clients are asking these kinds of questions, we're really looking for signs of metabolic flexibility if we're able to effectively utilize stored fats or glucose or create ketones. And so, I think about being able to go longer in between meals. If you can go four to five hours in between meals and have good amounts of energy, you're not having energy slumps after eating, you are able to regulate your weight, part of metabolic flexibility is having the ability to lose weight more effectively. But I think about the brain cognition piece being a big one, if you're able to effectively create ketones and specific ones can diffuse across the blood-brain barrier. So, mental clarity, energy sustained from meal to meal, not getting hangry, effectively being able to lose weight. Those are probably the big ones that I think about what about you, Melanie?

Melanie Avalon: Yeah, so those are really good for the signs, I guess the only thing I would add is as far as if you actually wanted to confirm or measure and we've talked about this at length multiple times on the show, but just to briefly go through it, you can measure ketones, there are caveats and nuances to all of it. If you're brand new to intermittent fasting, urine keto strips can be great because you will likely see that shift when you actually start generating ketones and a large portion of those ketones. Your body doesn't know how to use them in the beginning, so it like gets rid of a lot of them through your urine. The issue with urine sticks ongoing is that as your body becomes more used to using ketones, you don't excrete as many through the urine. It's not a really good long-term way to monitor ketosis or you can also monitor blood and breath. Monitoring your blood, there also can be a little bit of that effect where you might see more in the beginning and then as you become better at using it, you might see lower levels on your blood ketone meter. That said, you should always see them, you're not going to be in ketosis and not see ketones on your blood ketone meter. So, that can be a good thing to monitor. I really like Keto-Mojo's brand of their ketone meter. And then you can also measure the breath. So, the breath is also a byproduct of when we burn ketones. Interestingly, Dominic D'Agostino has talked about this, he's made the case that breath ketones are likely more a product of when you're actually burning fat compared to like dietary fat, which I thought was pretty cool just because of the whole metabolic process and what would create those breath ketones, so you can get a Biosense meter for that if you want to measure breath ketones, and I do have a code. You can actually join my Facebook group has a long name, Lumen, Biosense & CGMs: Carbs, Fat, Ketones & Blood Sugar and then (Melanie Avalon) basically if you type in Melanie Avalon Facebook Group, I have three groups and this one will come up. You can get $20 off of Biosense. If you go to melanieavalon.com/biosense and use the coupon AVALON20. What are your thoughts? Cynthia on measuring all of these different ketone options?

Cynthia Thurlow: Yeah, I think they're nice. Certainly, Dr. Anna Cabeca talks a lot about urine ketones and when you're new to being in ketosis that can be valuable. But those kinds of things add up. That's why, I typically start with-- these are signs and then you can get further validation. I do like Keto-Mojo, I really, really enjoy the owners. I think that they're delightful and they're really trying to help change the narrative especially about insulin resistance and diabetes, and just making people more aware of the net impact of food choices and lifestyle on our blood sugar. I think those are certainly really great options. I'm not as familiar with Biosense, but obviously I know that you've done your due diligence, but I think the devices to me are secondary to actually getting to a point where you start recognizing the signs that demonstrate that you're becoming more metabolically flexible. And just remember, it's a very small percentage of the population here in the United States, right now, it's about 7% to 8% are metabolically flexible. So, really important for everyone to lean into that.

Melanie Avalon: Yes, I agree, I think that's so important, it's a fine line. I just wish everybody could have the full knowledge of ketones before engaging with these devices so that they have the healthiest relationship with the device and what they're learning from it.

Cynthia Thurlow: I totally agree.

Melanie Avalon: Yeah, because you don't want it to be something that is a hurdle to something that you're doing that's good in your body because you feel like you're not creating enough ketones. I think it can just become an issue. I actually never measure my ketones ever. And we actually have a question that we didn't get to today, maybe we'll get to it next week, about our diets and if we're getting into ketosis or not, and I'll say this again when I answer that question, but I might not be, I don't know, I might not be getting into ketosis, you can burn fat without getting into ketosis. Surprise, well, this has been absolutely wonderful. So, a few things for listeners, before we go, if you would like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can get all the stuff that we like at ifpodcast.com/stuffwelike although I have it on my to-do list, I really need to get that page updated. And you can follow us on Instagram. We are @ifpodcast. I am @melanieavalon, Cynthia is @cynthia_thurlow_ and I think that is all the things. Anything from you before we go?

Cynthia Thurlow: No. I'm just looking forward to our next recording and I promise that our first question won't take quite so long.

Melanie Avalon: Yeah, well, it was lots of questions.

Cynthia Thurlow: it was, very nuanced, but all good information that I think is applicable to most people that are listening.

Melanie Avalon: Yep. All right, well, this has been absolutely wonderful and I will talk to you next week.

Cynthia Thurlow: Sounds good.

Melanie Avalon: Bye.

Thank you so much for listening to The Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

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Nov 20

Episode 292: Creatine, Brain Health, Sex Hormones, Muscle Building, Insulin Sensitivity, Sarcopenia, Andropause, Mood, Motivation, BDNF, And More!

Intermittent Fasting

Welcome to Episode 292 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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SHOW NOTES

JOOVV: For A Limited Time Go To joovv.com/ifpodcast And Use The Code IFPODCAST For An Exclusive Discount! black friday thru cyber monday only get $50 off Joovv Go, $150 off Mini, $200 off Solo, $300 off Half-Max, $400 off Duo, $500 off Max, $600 off Quad, $800 off Elite plus Special Financing Offers! after that Use The Code IFPODCAST For An Exclusive Discount!

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Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

what is creatine?

the benefits of creatine

common misconceptions

body building supplementation

if you're considering supplementation...

what creatine does

Creatine Supplementation in Women’s Health: A Lifespan Perspective

GABA Research

creatine and brain health

LMNT: For A Limited Time Go To drinklmnt.com/ifpodcast To Get A FREE Sample Pack With Any Purchase! Learn All About Electrolytes In Episode 237 - Our Interview With Robb Wolf!

gender differences in creatine needs

creatine and sex hormones

sarcopenia

muscle memory

andropause

low testosterone, mood and motivation

BDNF

learning new things

age related changes in the body; Bone health

AVALONX berberine: Use The Code Melanieavalon For 10% On Any Order At Avalonx.Us And MDlogichealth.Com!

hormone replacement therapy

sleep

creatine sources and supplemental dosage

vegans and Vegetarians

Introducing... Creatine by Cynthia Thurlow

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 292 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine if it's that time and get ready for The Intermittent Fasting Podcast.

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You guys know how seriously I take my health routine. That is probably the understatement of the year. One of my literal non-negotiables that I talk about all the time that I use every single day of my life is getting my daily dose of red-light therapy. For years now, yes years, I've been using Joovv. And I love it because it is so relaxing and so easy to use. You've probably heard me talk about Joovv before. That's J-O-O-V-V. I use my devices daily to support healthy cellular function, which is the literal foundation of our health. If you've heard any of my episodes on mitochondrial health, you know this is true. Having healthy cellular function helps give me peace of mind that my body is working efficiently and has the energy that it needs to get through the day. 

There are so many clinically proven benefits from red light therapy and I have personally experienced so many of them. I use the red light to naturally regulate my circadian rhythm. I wind down with it at night and wake up in the morning with it. Whenever I have any muscle pain or soreness, I shine my Joovv red light on it and the pain instantly goes away. It's actually kind of shocking. I love it for skin health. It makes my skin glow. And you can also use it for things that I originally got into red light therapy for which was supporting my thyroid. Yes, I struggle with hypothyroidism and supporting hair growth. Aside from the benefits, I've been recommending Joovv for years because the quality of their devices is simply the best. 

Their modular design allows for a variety of setup options that gives you flexibility. Plus, the treatments are so easy and can be done in as little as 10 minutes. Although I tend to run mine all day as ambient light. All you have to do is relax and let your body take in the light. Joovv offers several different size options including a wireless handheld device called the Joovv Go. That is amazing for targeting specific areas around your body, like hurting joints or sore muscles.

When I traveled recently and had torn something in my knee, I brought my Joovv Go with me, game changer, I don't know how I would have survived the trip without it. Health doesn't have to be complicated and Joovv makes it simple by helping what matters most to our cells. So go check out the Joovv today and while you're there, Joovv is offering all our listeners an exclusive discount on their first order. Just go to joovv.com/ifpodcast and apply the coupon code IFPODCAST to your qualifying order. And, of course, do not miss those incredible Black Friday through Cyber Monday deals up to $800 off, now is the time.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream.

And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies when we have babies, a huge percentage of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years.

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life and their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. 

They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list, so definitely check it out. You can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well. 

And lastly, if you're thinking of making clean beauty and safe skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally completely worth it. So, again to shop with us go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now, back to the show.

Cynthia Thurlow: Hi, everyone, and welcome. This is Episode number 292 of The Intermittent Fasting Podcast. I'm Cynthia Thurlow and I'm here with Scott Emmens, cofounder and COO of MD Logic Health.

Scott Emmens: Cynthia, thank you for having me on the IF Podcast. It's a pleasure to be here with you today.

Cynthia Thurlow: Absolutely. Today, we're going to unpack creatine. I think this is certainly a supplement that I used to have probably prejudicial thought processes on, but the more I've understood the science and the more that I've understood about the benefits of creatine, both for men and women, the more I was interested in sharing the research and connecting with you. I'd really love to start the conversation there. What exactly is creatine? 

Scott Emmens: Creatine is organic acid that is endogenously produced in the body. You can also take it as a supplement. It's a combination of three amino acids, which are arginine, glycine, and methionine. It's produced in the kidneys and in the liver.

Cynthia Thurlow: Yeah, it's interesting. When I was doing my research before we even talked about bringing creatine to market, was it the liver and the kidneys produce 2 grams a day on their own and it's all stored in our skeletal muscle. And so, I think from my perspective as a clinician what I understood about creatine was that it was something just utilized by bodybuilders and what I've come to find out is there're so many variations of creatine, there're so many options available. The two consistent things that I saw in the literature that really stood out for me was the improvement on muscle health and muscle strength and then also the cognitive benefits. And so from my perspective, this is something that's applicable to everyone. It's not just gender specific, it really is applicable to everyone.

Scott Emmens: Well, it's been like a second coming from me, Cynthia, because I started out as a biology major and a bodybuilder in college. So, I'm very familiar with creatine. I'd used it back in the days when you took 20 grams and that was it. It was a bodybuilding supplement, 20 grams, by the way, is a lot, way too much, that can really cause some GI upset, kidney damage, and so forth over the long term. But at lower doses, it's really an effective product. What I was so blown away by was after 30 years out of the bodybuilding scene, gauged myself a little, I could not believe how many studies are continuing to go on with this product and how much more benefits that we're seeing across a wide array of issues including brain health. That was one thing that shocked me the most was the number of different studies that are ongoing, or that are in early trials for various different brain health issues.

Cynthia Thurlow: Yeah, and so because you started your experiences with creatine at a different stage of life, what have been some of the common misconceptions that you have seen or heard over the last 30 years particular to creatine use?

Scott Emmens: First of all, that it causes weight gain or weight gain in women, which is highly unlikely, it's not zero probability, that it can be very dangerous with a lot of controversy about the danger of creatine. It's in fact one of the most studied supplements that I've ever seen, it's been studied and researched well over 30 years at this point. So, its safety is pretty much unparalleled. And then the other misconception because, A, it's only for bodybuilders or for only for men, or that it's only for athletes. When in fact the research shows that there are many people that can benefit particularly by vegans and women that benefit from making sure to maintain muscle mass, especially postmenopausal. So, there's just a tremendous amount of research coming up. This is an [unintelligible [00:12:12] nutrient that your body requires creatine. In fact, if you have creatine, it can cause some pretty significant problems.

Cynthia Thurlow: Absolutely. It's interesting because I admittedly was a little prejudicial in my thought process, and I think it was because my knowledge of creatine was really related to the bodybuilding set. At one time, I was an ER nurse in inner city, Baltimore, and I saw quite a bit of people that are using anabolic steroids and they were using other types of supplementation. I'm sure that creatine probably got lumped in with some of the other side effects that were completely unrelated to the creatine utilization and more a byproduct of illegal exogenous use of anabolic steroids.

Scott Emmens: I can attest to that having been in that world, you would get approached with someone trying to sell you something that was illegal on a regular basis. And as a person of health, it just wasn't in my wheelhouse. So, I had to understand how these products worked. And I was a big supplement user in my early age because in order to compete with people that were using anabolic steroids, they can go eat a pizza and still look ripped. Whereas for me I was doing things like creatine and using things like boron and zinc combinations and other minerals, amino acids and branched chain amino acids and the essential amino acids way before they became popular or in vogue. There was definitely a large combination of people in joining creatine and other including diuretic cause other serious problem.

Cynthia Thurlow: Yeah, absolutely. For full disclosure, I had been skeptical about creatine until my very well researched trainer, who's also an attorney, she's got a really interesting background, she was actually sharing the research last fall and kept saying, "I really think you should consider supplementation with creatine." The one thing that I have found personally and we'll talk about this today, the benefits of creatine, how it works in the body was that I went from as a menopausal female, when women really do struggle with not only building but maintaining muscle mass unless they're taking exogenous testosterone. I was able to consistently lift heavier weight week to week and I was able to see more of those gains, and we track all of our metrics because she and I are a little bit OCD about this. For me, I kept saying, "If I am capable of achieving and maintaining muscle mass at this stage of life I am in, then this is something that can be really beneficial for other women and certainly other men that are considering wanting to build maintain muscle mass because we think of muscle as an organ of longevity." Certainly, I follow really closely with Dr. Gabrielle Lyon's work and she was very excited when I told her that I was seriously considering bringing creatine on as my first product in conjunction with MD Logic. 

Let's talk a little bit about what creatine does. From a technical perspective, creatine re-phosphorylates utilized ATP. So, ATP is this energy molecule in the body. Adenosine triphosphate becomes adenosine diphosphate when you move muscles, so your body's using this energy when you're moving your muscles and creatine actually attaches another phosphorus group to ADP. So, it's a way to keep recycling creating the stored energy. And for anyone that's listening that saying, "I don't even know what you're talking about." We're talking about what goes on inside the mitochondria. This is a very savvy science-oriented listener base. And so really think about this is going on in the mitochondria. So, the powerhouses of our cells.

Scott Emmens: I think what's important for people to understand too, is that sometimes we associate ATP with just our muscle cell. But in fact, it's all of our cells. It's your brain cells, your heart cells, all of the cells in your body, your immune cells, every cell in your body requires ATP for energy. If you run out of energy, then you're going to run out of life. What creatine is able to do is to your point, make that ADP back into ATP, which is the foundational molecule for energy, much faster, you got creatine stored in your body and creatine serum in your blood going to replace that quicker, and your brain and your heart probably use up more ATP and more energy that get into organs in your body. So, it makes sense when you think about how it could work for your brain because of the way that works on ATP.

Cynthia Thurlow: Absolutely. It's involved in energy mobilization and metabolism in the brain. I also think about the net impact on things like glycine and GABA, which impacts sleep. As women, especially in their perimenopausal years, 10 to 15 years preceding menopause and their ovaries are producing less progesterone, this is a time when upregulation of GABA is really important for high quality sleep. When you really dive into the research, one of the things I found interesting and there's a great article that we'll link up, it's called Creatine Supplementation in Women's Health: A Lifespan Perspective. Researchers here really talk about how creatine has a place throughout a woman's lifetime, not just perimenopause and menopause, but your menstrual cycle. We're not going to touch on pregnancy or lactation because I don't want to touch that with a 10-foot pole, but there is research that kind of touches on how this can be beneficial. 

It's not just as you said, it's not just the muscles, but it's really a systemic supplement that has a lot of benefits. The one thing that I really like about this article in particular is that it admits despite extensive research on creatine evidence for use among females is understudied, so they acknowledge like many things, there's not enough research being done on women in peak fertile years, in perimenopause and menopause. But they do see the importance, it actually says supplementation during menses, pregnancy, postpartum, during and post menopause. Again, we're not talking about pregnant or lactating women, but we'll talk about women that are still in their peak fertile years, perimenopause, and menopause, that there really are quite a bit of benefits from supplementation.

Scott Emmens: Yeah, absolutely. It's not surprising that it wasn't studied and even that happens, they're quite often. I did find it interesting that there are some variations in women that have or store creatine. So, I'd like to talk about that when we get a chance. But I didn't read this research that you read on sleep and GABA upregulation. Tell me a little bit more about that.

Cynthia Thurlow: It's interesting that it can have a positive net impact. There's an excitatory neurotransmitter and that's glutamic acid and then there's inhibitory neurotransmitter and that's GABA. The thought processes is that the creatine absorption will upregulate the inhibitory neurotransmitters, it also has some impact on neuronal ATP resynthesis, which impacts areas in the brain that will impact memory, cognition, and attention. Again, it's downregulating excitatory areas of the brain and helping to facilitate concentration as well as relaxation. There was research and in one of the articles that I had shared with you talking a little bit about the sleep piece, it wasn't a huge area of focus but I think in particular, for individuals that are north of 35 or 40, where sleep becomes much more of a-- I always say jokingly, it becomes an art form, all of a sudden you have to think a whole lot more about it. You have to think about what you're doing preceding bed, what you eat, what you drink, whether that's alcoholic or not, and all the things you need to do in order to help facilitate sleep.

One of the things that it talks about in particular was this brain metabolism and then also secondarily to that it's involved in the synthesis of key neurotransmitter, so it's actually found in the cerebral spinal fluid, which is important. There are actual dopamine and serotonin and creatine metabolites that they're finding in the cerebral spinal fluid, which means that it must have some good absorption. When we talk about the blood-brain barrier, there are some things that are able to cross the blood-brain barrier and there're some things that are not able to cross the blood-brain barrier and so that's pretty significant. If we're getting cerebral spinal fluid levels, then you've got some good absorption in the brain, which a lot of supplements and drugs do not have good absorption in the brain, and that can complicate how well or how effective they can be.

Scott Emmens: I saw another article on just specifically creatine and brain health and talk about being able to cross the blood-brain barrier. The fact that it was able to do that really gave the brain some neuroprotective properties as well. And they think that that also could be because the brain has more energy. That was interesting. I think this goes back to the ability to focus and concentrate, not get excited. It's usually if you have a stimulant or something that gives you energy going to make you jittery, but this has the opposite effect where it calms you, but also gives your brain the ATP that it needs to perform. And so, the hypothesis is that your brain fatigue comes from the fact that it's eating up the ATP faster than it can create it, so that that creatine crossing the blood-brain barrier really allows your cognition to be at a constant steady level, because, I think, where the real benefit for so many of us come from, if you're getting good sleep on top of that, well, then your cognition is going to just continue to enhance.

One thing I just want to go back to, Cynthia, you said when you first started taking it, you felt yourself getting stronger. I wanted to point that out because as a former bodybuilder and a trainer, one of the things that happens, you can start to lift heavier weight, it then becomes a positive cycle upward. Because as you lift heavier weight, you get stronger, as you get stronger, you get bigger and stronger muscles. Of course, you hit a point where you've hit a plateau, but the fact that that gives you that jumpstart to be able to lift heavier weights allows for both your skeletal system to get stronger, your joints to get stronger, as well as your muscles to get stronger and protect yourself from sarcopenia, and we're going to talk about later, which really is serious at the end of the day. I mean, it's sort of the beginning of the end stage of life and certainly a predictor for longevity.

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Cynthia Thurlow: I think that a good place to start is perhaps talking a little bit about gender differences. There's no question that men and women can both benefit. But it's interesting, from a perspective that women actually make less creatine than men as a standard. That could be related to so many different factors but understanding that just at a cellular level, our bodies make less of this substance. I would argue that it makes it even more important to consider supplementation to help maintain muscle mass, brain cognition. When we're really looking at such a small percentage of the population, back to brain health, only 7% to 8% of Americans right now are metabolically flexible. This is research looking post pandemic, pre-pandemic it was 12%. Now even less people. And so really thinking about ways to augment metabolic flexibility. One of those is really leaning into lifting weights, intermittent fasting or eating less often. It could be 12-hour feeding window, just really understand there are a lot of things within our control that we can do to utilize supporting health and wellness. 

I always say, "My greatest hope is that people look at-- They don't fear aging, but they understand that you don't want to just survive, you want to thrive at each stage of life." If you're peak fertile years, perimenopause, menopause, really important to understand you want to have a high quality of life.

Scott Emmens: Absolutely. There's definitely differences between men and women. Women do make significantly less creatine. From the research I could see, estrogen did play a role in that and it did go along with the cycle. There definitely seems to be something there, which to your point makes it all the more important for certain populations, I think women being one of them, which is ironic because it's been utilized in male bodybuilding role for so long. But in reality, women will benefit tremendously from creatine.

Cynthia Thurlow: Yeah. There's a really good graphic that's in this one study that I'm looking at. It's talking about the menstrual cycle may influence creatine homeostasis due to the cyclical nature of sex hormone regulation. You mentioned in particular that it's sensitive to estrogen, which also explains why women and perimenopause and menopause that are having these faltering amounts of estrogen may have even greater needs. But you can actually plot on this graph they have on the X-axis is creatine kinase activity and estrogen and progesterone concentrations and then on the Y-axis, they're looking at different phases. The follicular ovulation, luteal phases, which everyone in this podcast is very familiarized with. You can literally look at how they plot out. Glycogen storage, carbohydrate oxidation dependent on how much sex hormones are and where they are peaking and where they're ebbing and flowing throughout the menstrual cycle. 

It's interesting that we know that estrogen influences creatine and also creatine kinase, and that estrogen in and of itself is a master regulator of bioenergetics. What does that mean? As we are losing estrogen either in our menstrual cycle, or in perimenopause or menopause, it is a direct reflection of the loss of insulin sensitivity. So, obviously, in middle age, it's going to eventually be a permanent thing unless you're taking hormone replacement therapy. For menstruating women peak fertile years, they have cyclical alterations in their estrogen month to month and that is the ebbs and flows. They have days where it's higher and lower throughout their menstrual cycle, whereas with middle*aged women, they're on a downward trend. Ultimately, they'll be on a downward trend.

Scott Emmens: Yeah, that's very interesting. When you said that estrogen is the master hormone for-- what was the word that-- [crosstalk] 

Cynthia Thurlow: They use the term bioenergetics. 

Scott Emmens: Bioenergetics.

Cynthia Thurlow: Which makes sense.

Scott Emmens: So, essentially, once you have no estrogen, your bioenergetics is essentially completely downregulated.

Cynthia Thurlow: You're no longer in anabolic growth phase of any kind, you're really in this catabolic phase unless you're actively progressively working against it. From my perspective, is we've touched on sarcopenia, which is this muscle loss with aging. It's not a question of if but when. People if you think you do nothing and I can now recognize middle-aged women or even older women that are just skinny, and it's because they've lost their muscle mass. They really start replacing adipose tissue, which is highly inflammatory with our muscle tissue. I always use the analogy because I'm very visual. When we're looking at nonsarcopenic or healthy muscle tissue, it looks like filet versus a ribeye. People love eating ribeye but we don't want to become a ribeye, and I use that to understand, like the marbling in the meat is what starts happening to your muscle, because you're losing muscle mass. 

In fact, I was at an event this summer, actually, with Gabrielle Lyon and a few other people. There was a special type of scale that you stepped on. And it could tell you pretty accurately how much muscle mass you had on. She and I had a pretty good laugh when we're looking at my results. But the point I'm trying to make to everyone is that you want to maintain muscle mass, like your life depends on it. I don't think I appreciated that enough in my 20s and 30s. Certainly, you start seeing the slippery slopes. Forty is about when we start losing a significant amount of muscle mass, and then it just accelerates. So, you want to be doing all the things you can to maintain as much as possible, so that you're less at risk for metabolic diseases, insulin resistance, etc.

Scott Emmens: Cynthia, I've heard you talk about this on the IF Podcast before and in Everyday Wellness as well, that sarcopenia creeps up on you. But also, when you're in your 20s and 30s, what should you be doing? In my personal opinion and experience, people that have built up their muscle in their 20s and 30s, when they have all those natural anabolic hormones circulating through the blood tend to do much better when they hit their 40s and 50s if they're continuing, even if they're just doing a maintenance work out or just push up and pull ups, the basics. You'll see that the people that kind of had that foundation tend to stay better. It's never too late to start right, but if you're in your 40s, and you haven't been working out, you probably should hit the gym and get a trainer and learn how to work out is the point of no return. And that's the point where you've really got to face the fact that, "Hey, if I don't have muscle in my 60s and 70s, my knees are going to be rough. And that's the way you don't just have longevity, but you have health span. If you want to be healthy in your 80s, you got to be able to get yourself up out of a chair without using your arm, just to be able to stand up. And that sounds easy. But when you're 80, it's not so easy. 

I completely agree that, A, you've got to make sure that you have a foundation if you're 20 or 30 now you're listening to this podcast, start making your muscles strong now. You won't regret it. You will never regret having really strong lower legs and really strong arms and shoulders, and a strong back and a strong core. You've never going to regret that. And creatine is one of those things will help you get to that place in a very natural way. It's a natural substance that you get from meat, but your body is usually excreting more than it's taking in and extra creatine has been demonstrated time and time again to help you get there. 

The other statement which I thought was profound is that you're in a constant state of anabolic state, constant catabolic state after menopause. That basically means you're eating your own muscle tissue. And that is a dangerous place to be. I would really recommend those folks also hit the gym, take both protein whether that's in the form of essential amino acids or whether that's in the form of a protein powder, combined with the creatine, or get the protein from your diet. That’s how you got to be getting about a gram per pound, in my opinion, protein a day. It might be less, women may be 20 grams per pound, you definitely need to have that protein. And creatine is one of those things that'll make that proteins better for you. All that said, it's all going to work much better for you if you're working out with weight.

Cynthia Thurlow: No, I agree with you and you really bring up some excellent points. I always use myself as an example because it makes it relatable. We have muscle memory, so if we've been working our muscles for years, or even if we go through a period of time where we take a break, when we go back to training, we'll be able to get back to where we were a little bit faster than someone that's new. But in 2019, I spent 13 days in the hospital, I lost 15 pounds, all of which was mostly muscle. And there were many, many months where I was convinced, I was using bands. I mean they had me doing bodyweight exercise and then bands and then I could finally graduate to using weights. And the one thing my trainer said, because at that point I was coming back from a long hospitalization. I did hire a trainer because I didn't want to hurt myself. I remember him saying, "You're at an advantage. Although you've lost a lot of your muscle mass, your muscles once they start growing again, they'll know what they need to be doing." 

I encourage everyone to-- if you're not currently lifting or doing weight training, even if you start with bodyweight exercises and then graduate to bands and graduate to dumbbells and graduate to get to a point where maybe you're using machines, really take the time to be thoughtful about understanding the physiology of your body. I don't believe in having regrets, but I do wish someone had talked to me in my 20s and 30s about the fact that when you're at your peak bone and muscle mass, and then you just start to have this slow, slow decline that you may not even be perceptible for a long period of time. And men go through this too. Let me be very clear. Andropause is a real thing.

Men, much like women, they may not have as exaggerated demonstration, women go through reverse puberty, that's essentially what's happening in perimenopause. Men can go through andropause and they may have trouble maintaining muscle, they may have trouble building muscle. Most of the reason why men in the States start losing testosterone is from exogenous sources of estrogen mimicking chemicals, also from insulin resistance. Again, we go back to the same things about maintaining metabolic flexibility, how important that is, that I'm sure for those of you that are familiar with both Melanie and my single podcast, we talk a lot about toxins, we get exposed to our environment, our personal care products, our food, it is important, you do want to care about those things. But maintaining muscle mass is of particular significance. And if you're not currently lifting, you can change that. If you start off really simply, it can make such a big difference. 

The one thing that I found working in hospitals for over 20 years, there's nothing more sad than having a 55-year-old patient that can't get off a bedside commode because their muscles in their quadriceps, which are their big muscles in their legs have atrophied from lack of use. If you don't use it, you will lose it. And that's why I think it's so important to understand that we're not saying this is just related to aesthetics, we're just saying from a functional perspective, you want to be able to get out of bed, you want to be able to get off a toilet, you don't want to fall, fall risk is significant. You don't have to be 60, 70, or 80 years old to be at a fall risk. We had plenty of younger patients that were just so sedentary that they had really lost their muscle mass, they didn't even realize it until they got to the hospital and they were so weak, they just couldn't do normal, we call them ADLs, activities of daily living, and this is quite significant.

Scott Emmens: Yeah, absolutely. I can relate to that on two personal notes. First, at 52, I feel like I might be hitting andropause. Is that a real term?

Cynthia Thurlow: It is a real pause. It is a real term, but it's not utilized as openly probably as menopause.

Scott Emmens: It's getting more difficult for me to maintain muscle mass, but to your earlier point, two things. One, on a humorous note, you work out for 15 years, you put on 30 pounds of muscle, you spent 13 days in the hospital, and bam, you lose 15 [chuckles] pounds of the muscle like that. It's not quite fair on the working, how fast you lose that. But that goes to show you that if you're not maintaining it through diet and exercise and supplementation, you're going to lose it, just naturally. So, I do feel that. In fact, since we started working on this project together, I've been up my dose of creatine, I used to take every other day when I worked out. Now I'm taking it every day. I've actually seen a difference in about just the last couple of weeks. That's been nice. But my dad who is--

Cynthia Thurlow: [crosstalk]

Scott Emmens: Thank you. My day who is 74, this was four years ago, we went to Lake George, and we were at my uncle's house and he couldn't get out of the boat. I had to literally pick my dad up out of the boat. And I took my dad in the house and then we chatted as well later that night, I just sat him down and I said, "Hey, we're going to have to get you working out again because if you can't get out of a boat by yourself, and you're living on your own, I'm nervous where you're heading." I didn’t even call it sarcopenia but I said muscle wasting at your age is the first sign of you kind of going downhill. I know what your life goals are. And at 74, you shouldn't be not able to get out of a boat. And now he's on the Stairmaster doing an hour and a half a day, and I'm thinking he's doing better than I am. So, I'm really proud of him but I saw that firsthand at 74, he's in better shape at 78 than he was at 74.

Cynthia Thurlow: It just goes to show you that you don't have to be 20 and still see benefits from weight training and physical activity. We are designed as human beings to be active. I unfortunately, probably not our listeners, but looking at the general population here in the United States, people are far less active than they should be. It's almost like a domino effect. I'd plenty of cardiology patients that they would say, "It's too hard to get back in the game." One thing that I will share with the listeners is that, low testosterone and so that can happen in perimenopause and menopause. It can happen to men as well. It's important to know that a sign of low testosterone is a lack of motivation, a lack of desire. 

Last year, I was on a full complement of hormone replacement therapy and we found that I was on like way too much and so we stopped it. I had a six-week washout. You can imagine you go from feeling pretty good to then feeling pretty bad. I remember talking to Gabrielle Lyon and I said, "I can tell my testosterone is low because I have zero motivation to go to the gym, which is not me. I have zero motivation to do these things. So, I had to really just force myself to do it. But I want to just identify and be fully transparent and say that that can be a sign your testosterone levels are low if you're really feeling incredibly unmotivated." This also ties into one other benefit of creatine use that I think is really interesting. And we're looking at a study that it talked about, as an example, depression is not vis-à-vis, it's related to many factors, gut health, situational circumstances, etc. But we know that depression in women is two times higher. We know it's directly linked to hormone milestones like puberty. 

I have two teenagers, trust me when I tell you, they are grumpy and moody. It's also linked to menopause. What's interesting is that if you have a low creatine intake, either from diet or supplementation, you're at 31% greater incidence of depression than those that are taking exogenous creatine supplementation and/or getting it from animal-based protein. I thought that was really interesting, especially coming off the tail end of the past two and a half years. We won't mention what's been going on, we're all quite aware of it. But I think for a lot of people just also understanding that there's also this mental health benefit from creatine use that keeping adequate levels of creatine endogenously in the body is intricately interwoven with depression and anxiety as well.

Scott Emmens: That really struck me, was not only is it good for your cognition, your focus, but your mood as well. It seems to have from this early data we're looking at, some significant enhancement on your overall mood, motivation, and really depression, which is interesting. I'm not sure if there was a mechanism action identified in that but it's just remarkable how important creatine seems to be for your overall mental health.

Cynthia Thurlow: There was also some research I read about BDNF, so brain derived neurotrophic factor, which we know is a stimulatory protein, it diffuses across the blood-brain barrier, but we know that it increases new brain cell production. So, it's increasing neuroplasticity, while improving the performance of existing brain cells. And so higher BDNF is a lower risk of depression. So, I wonder if it's tied into that. It's interesting how just the process of aging and stress can decrease BDNF, especially those that are not actively learning your skills or hobbies. We're going to touch on neuroplasticity here but this is why you were going to be lifelong learners. We should always be learning. I just spent the weekend with one of my college roommates and we had an amazing time, and she's a teacher, and we were talking about this. She was saying even in like her own teaching population that she said those that are still continuing to take classes and learn are thriving, and those that are kind of at the standstill, colleges 30 years ago, and they haven't really taken-- they don't do continuing education, they're not investing in conferences, they're not listening to podcasts, they're not reading books, and how that's impacting their brain health. This just validates that aging and stress can impact BDNF. We also know that creatine in and of itself vis-à-vis can improve BDNF levels as well in the body. So, it's neuroplasticity, learning new things, exogenous supplementation can also be beneficial for brain health. 

Scott Emmens: Yeah, I'm obsessed with BDNF. Everything that I think can raise brain derived neurotrophic factor. I figure, "Well, how can that possibly hurt?" And exercise is one of those things. Again, we're back to a positive circle up. If creatine helps you get more motivated, helps you get better exercise, you get more exercise, we know exercise is good for BDNF as well. So, it's sort of a nice cycle upward instead of the cycle down. Lack of exercise is going to lower your BDNF, lower creatine is going to lower your BDNF. Again, this is a nice way to think [unintelligible [00:43:59] cycles down, how can you cycle up and the way that you do that, you take creatine which helps you exercise, which helps BDNF, which helps you exercise and helps BDNF. 

Just a quick aside, there was a recent study that came out as an avid tennis player, I have to mention this, they showed that tennis both extended your lifespan, but the longest of all sports, but also had the best impact on your overall brain health because it's both a sport of strategy, at the same time you're running around the court, but it also applied to pickleball for those of you who are getting into pickleball, which is the new rage. Even works in ping pong. Ping Pong had a really positive effect on the brain. So, you're looking for some exercises to help with your brain. Paddlesports, badminton, tennis, pickleball seems to be the best.

Cynthia Thurlow: Yeah, it's really interesting how important I think it is for people to be either it's the hand-eye coordination or just the concentration, but doing things that make you a little-- when I say uncomfortable, I'm not talking physically uncomfortable per se, but just intellectually, like pushing yourself, learning something new, getting outside your comfort zone. I have a friend that's learning, I don't know why she wants to learn a language. Someone in one of my group programs, who thinks she loves to do puzzles for that exact reason that she wants to push herself outside our comfort level. I was actually mentioning to my husband, he just started doing Brazilian jiu-jitsu right before the onset of the pandemic. He was a college athlete. Now that we're in a new part of the state, he is unable to play seniors level lacrosse. 

For him, he said, "It's like playing chess." But he gets to roll around on a mat with-- sometimes guys that are like 20 years younger than him, but he can hold his own and of course you know he is a former college athlete, he loves that. He gets that validation that he's still strong and virile. But I think for each one of us, we have to find ways to constantly be challenging ourselves. I think, on a lot of levels, we're just so fortunate to be in a time where information is accessible at any point in time. I have a large stack of books. I'm always reading. I'm always prepping for podcasts, but I haven't heard a lot about pickleball. I don't know how it differentiates from tennis, and I don't want to take like a huge rabbit hole jump. But I'm just curious how different is it than tennis, I know it's with a racket and a ball.

Scott Emmens: It's kind of if you were to combine ping pong and tennis and put yourself on the ping pong table, that would be the best way to describe that.

Cynthia Thurlow: Interesting. 

Scott Emmens: It's a lot less running and a lot more about sort of teamwork and strategy usually playing doubles. And it's just so much fun because it's fast paced and you get crazy wild points. It's just a lot of fun, but it's a lot of good exercise too without having to run all across the court. If you want to learn pickleball, it's the sport to get into. It's the fastest growing sport in America.

Cynthia Thurlow: I'll definitely have to check it out because my husband and I will be empty nesters in four years. For us, we're looking for all sorts of ways to do things together and new things together. Let's talk about some of the age-related changes that happen in our bodies and how creatine can potentially be a countermeasure to changes in muscle and bone strength. It can be implicated in reducing inflammation and oxidative stress. I did see a couple articles talking about improvement in bone reabsorption. But when I went down that rabbit hole, I didn't feel the strength of the research was strong enough to be able to say this is an indication per se. Maybe in the future, we'll hear more about it but I do think in particular for people in menopause, andropause, where we are de facto in a state of chronic low-level inflammation, sometimes high-level inflammation if we're insulin resistant and metabolically unhealthy, but how creatine can be beneficial for these specific timeframes.

Scott Emmens: Let's quickly address the bone issue. So, I went down the research rabbit hole on bone and couldn't find anything specific for creatine that was definitively positive. I think the reason for the mixed results, and this is just my personal opinion. But, again, I think it goes back to, if you're able to lift heavier weights or use heavier bands, really what we know for sure is that if you're putting weight on your skeletal system that can tolerate, it's going to stimulate proper bone growth given you have the right nutrition. I think what creatine can do is by making your muscles stronger, allowing you to lift heavier and heavier weights under the guidance of professional trainer and [unintelligible [00:48:34] hurt yourself. That, I think, in and of itself could be the way that creatine could help with bone. It may not be a direct result. It may be an indirect result of creatine. It's just a theory because I couldn't find anything definitive in the research.

Melanie Avalon: Hi, friends. I am so thrilled to announce that my next AvalonX supplement is official and almost here. It is something that I currently take every single day of my life and that is berberine. I first started taking berberine when I first started using a continuous glucose monitor which constantly monitored my blood sugar levels. I found that taking berberine had a dramatic effect on my fasting and post meal blood sugar levels. Berberine is a plant alkaloid which has been shown to rival Metformin when it comes to reducing blood sugar levels without any of the side effects. Blood sugar regulation is so important for health. It's a key factor in metabolic syndrome and preventatively taking care of your blood sugar levels or treating high blood sugar levels is so, so important for health and longevity. That's why I am thrilled to be making a berberine supplement. And it's not just blood sugar control, berberine has been shown to have so many benefits. It's been shown in studies to beneficially modulate adipose tissue. It can actually help change the composition of your fat to a more healthy profile. Think less visceral fat, which is the inflammatory fat found around our organs. 

It's also been shown to have beneficial effects on PCOS and reductions in inflammation and is a potent stimulator of autophagy, which is one of our favorite things. Berberine has also been shown to have a beneficial effect on blood lipids, which is huge, and I wanted to make the best berberine on the market. We looked so hard to find a source of berberine that tested to be high potency and free of pesticides. Yes, we did third party lab testing on our source, as well as testing to assure its quality. It is tested multiple times for toxins including heavy metals and mold, and has no problematic fillers. It also comes in a glass bottle to help prevent leaching of plastics into our cells and the environment. This is the berberine that you want, I promise. And it is coming midnight of Friday, December 16th. To get all of the updates about it, definitely get on my email list that's at avalonx.us/emaillist, we'll be announcing the launch special on that list. 

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Cynthia Thurlow: Yeah, I was the same. I went down that rabbit hole and I wanted it to be true. But I didn't feel like the research was strong enough to say this is an indication per se. But I would agree with you that someone that's going to work diligently about building maintaining muscle is very likely getting improvement in their bone health. One thing I just want to interject is that our bone building accelerates in puberty and then it plateaus. And then interestingly enough in andropause and menopause, but I can speak more specifically to women because I'm more familiarized with the research. What starts to happen as our bone diminishing activity starts, osteoclastic activity up regulates, which means we're actively breaking down bone as opposed to building bone. And that's why women in many ways are at greater risk for osteopenia, osteoporosis at that time in their lives. Obviously, osteopenia is kind of a lack of a better way to put it, it's a diagnosis that was created by the pharmaceutical company, it's really not a diagnosis per se because they're comparing the bone tensile strength of a 50-year-old to a 20-year-old and you can't compare that great of a difference in age. Osteopenia, I don't get terribly concerned about but obviously osteoporosis is significant, and really does need to be addressed proactively.

Interestingly enough, one thing that kind of accelerates a lot of these processes in the body in women is that as we have lower and lower estrogen level, so tail end of perimenopause because in menopause, we can have very high estrogen levels prior to going into menopause, is that this is what really drives inflammation, it drives the oxidative stress, it drives the degree of insulin resistance. And it also blunts muscle protein synthesis, and also satellite cell response to anabolic stimuli, which is a fancy way of saying strength training. It's not in your head. If you find that in perimenopause and menopause, it is a lot harder to build muscle, you are working against hormones. The hormones that are saying, "There's not enough estrogen around." Estrogen is definitely one of these hormones that we have estrogen receptors throughout our body, but directly impacts this muscle-protein synthesis, and so it is not in your head if you're struggling to maintain and build muscle. Estrogen and testosterone can definitely play a role in that.

Scott Emmens: The power of hormones is undeniable. You feel it when you go through menopause, you feel it when you go through andropause, you see it when people take artificial steroids. If you look a gentleman or woman on steroids, you can tell, at least I can tell. They're very powerful. People also underestimate the power hormones on your mental cognition as well. A lot of effects on your mentality, as you're alluding to earlier about when your testosterone lowered, you'd have no motivation. You think that's in your head, but it's not. It's a hormonal issue.

Cynthia Thurlow: Exactly. The Women's Health Initiative is a study that I definitely talk about on the podcast, but in 2002, the Women's Health Initiative really changed the narrative and the comfort level of clinicians prescribing hormone replacement therapy, made many, many patients scared. There's no other way to put it. Scared to take hormone replacement therapy. I did a really great podcast with Dr. Avrum Bluming and Dr. Carol Tavris talking about this. He's a clinician, he's a physician, he's an oncologist. She's a researcher and they really debunk the Women's Health Initiative. Unfortunately, it was done on an older population of women, they already had insulin resistant, they were former smokers or current smokers, they had high blood pressure, a lot of health issues, and they put them on synthetics, and then drew conclusions from that. I always like to just interject, there's no judgment, there's no shame. I see a lot of women who are fearful to take hormones and so they're white knuckling it into perimenopause and menopause. Each one of us has to make a decision. This applies to men as well. Each one of us has to make a decision that makes the most sense to us. But understanding that hormone replacement therapy can be very beneficial, in particular for muscle and bone and brain health, and cardiovascular health, etc.

Scott Emmens: I've heard that podcast and I paid very close attention because I was in the pharmaceutical industry in 2002 when that study came out, and I was partnered with Eli Lilly, I think they either funded this study. They were making a product for hormonal replacement therapy for osteoporosis is what it was. And doctors stopped using it and folks frenzy and I read that study, then I thought, "This seems awfully skewed." It's 20 years later and just the other day, I kid you not, I heard people talking about that study in a negative light, which is a lot what happened to creatine, what are some of the common misconceptions. People thought, "Well, it's bad for your kidneys, it's bad for your heart," and had all this negative press going into it. But that stuff is 20, 30 years old, it's been one of the most studied supplements there is. It's interesting that you use that study because this is tantamount to that like, this is one of the best things you could do. That study sort of ruined HRT for a lot of people, which is a shame.

Cynthia Thurlow: Absolutely, because there's a whole generation of women. I think about my mom's generation that have really suffered needlessly because they were told that it was going to give them cancer. We've now figured out that that's not actually the case. But let's sling back to sleep and sleep deprivation. The reason why I think this is particularly important, we get a lot of questions on the podcast about sleep. We know that high stress, chronic stress will actually deplete not just creatine stores, but actually ATP. So again, less energy circulating. And we know that supplementation with creatine based on the research that we've both been looking at, can impact tasks that rely on the prefrontal cortex, which is our executive functioning brain, the one that helps with cognition and attention and memory, very important. Also very important because we know women are more sensitive to sleep deprivation, and particularly women that are most at risk, or the women that are pregnant, breastfeeding, postpartum, and menopause.

Based on this research I was looking at and I thought that was really interesting, because for any woman that's listening that went through pregnancy and then had the postpartum period where you weren't sleeping for weeks or months on end, that's pretty harrowing, but also in the same research article, they were talking about menopause as the same degree of sensitization to sleep deprivation. I think a lot of women that are listening or women know of other women who have spent years of having terrible sleep deprivation in middle age both in perimenopause and menopause, and it's totally normalized. I think that's really, really unfortunate.

Scott Emmens: It is and there was actually a study, I don't know if it was one of the ones you have had send me or one that I had read separately, that talks specifically about creatine's ability to support brain fatigue and sleep deprivation. I wouldn't call that a band-aid, what I would call that is going to allow you to get the energy you need to function throughout your day properly, so that when you do go to bed, you're back in your rhythm because one of the things that we know about sleep is it's all about your rhythm, your circadian rhythm, your exposure to light, your lack of exposure to light in the evening, your cortisol spikes and peaks amongst other things, but sleep is a lot about rhythm. If you don't have enough energy during the day, and you're resting all day, and you're sitting down all day and you're not active, well then what's going to happen at night, is you're going to kind of be that wire-tired mode, you're exhausted, but yet you're tired. 

The information I looked at really said, "Hey, look, if you're in this sick deprived state, not only can it help you get out of it, and really help your brain heal itself and be as active as it was and it gotten that sleep." To me, that's a way to reset your circadian rhythm at least your energy circadian rhythm, and then you've got to do other things obviously to support that.

Cynthia Thurlow: I think it's really important. And it's something that I didn't realize until I was looking at the research that what has been different over the last couple months, in particular, because I've been taking creatine consistently, was my sleep quality is improved and how do I track that? I track that on my Oura ring? And then I probably will screenshot it and share it in IG stories and people say, "Oh, my gosh, how did you get that much deep sleep?" And I'm like, "I think it's a couple things." But I keep trying one thing, pulling that out, trying something else because sleep in many ways becomes an art form. And I don't think I ever thought about sleep to the degree that I do now. But knowing that potentially the creatine I've been taking has been improving that sleep support, which again I think most, if not all women, and men for that matter, would truly desire to have better quality sleep.

Scott Emmens: Yeah. I've been a chronic insomniac pretty much my whole life. Recently, I've been sleeping pretty good. Got the whole system down. I do the light in the morning, try to keep it dark in the evening, creatine, occasionally I'll do melatonin when I feel I just need to reset my clock. But I've been doing really well. I'm getting up at the same time every morning, going to bed at the same time every evening. And I have been taking creatine now for a couple of weeks almost every day.

Cynthia Thurlow: That's great. Well, probably important to talk about where we can get food sources of creatine. And then talking about dosing because I think that will be a huge question for many people. How much do I need? I'm carnivore-ish, do I really need more? The answer is yes. But what are some of the sources of animal-based protein that are most creatine dense, I guess is the way to put it.

Scott Emmens: It's going to be all of your essential meats. It's going to be steak, in turkey, things of that nature. I don't think fish has a ton, but it has more than that. But basically, the really only place you're going to get creatine in your diet is from various meats. So, it could be pork, it could be yak, it could be bison, but meat is really going to be the only substantive way to get it into your diet. Eating meat, you're going to really be at risk for being low in creatine. If you're a vegan or vegetarian, especially if you don't eat any fish, you're going to be at serious risk of a major creatine deficiency. Even if you're eating meat, there's not really enough per kilogram if you look, it's like, I don't know, I can't remember the exact numbers, maybe you've got it at your hands. But it's something like 0.8 milligrams per kilogram of meat. Well, the kilogram is 2.2 pounds. I don't eat 2.2 pounds of any meat. So, there's not a ton of creatine going in. And the data I looked at says that average woman stores about 100 grams of creatine and excretes a net 2 or 3 grams a day. Men hold 120 and excrete about 2 or 3 grams a day as well. So, you're always in this negative deficiency unless you're eating enough meat to compensate for that. 

When it comes to the dosing, for me it's somewhere between 3 and 5, or 3 and 6, or even I'd even go to 9 if I felt like I needed some creatine because I hadn't had meat in certain period of time. But I think it is dependent on what your diet is like, are you vegan? Are you a carnivore? Athlete? Like, for example, my daughter is a Division I track athlete and she runs the 400 meter, the 100 meter hurdles. No, that is a lot of energy. She's got three-hour practices every day. So, I've got her on 9 milligrams of creatine a day, broken up into three doses, one with breakfast, one with lunch, one with dinner. My [unintelligible [01:03:46] actually like to take 9 milligrams all at once. I don’t take 9, I usually take 3, 3, and 3 or 5 and 5. I like to break it up. I have her just on 3, 3 and 3. And that changed her trajectory because in high school she wasn't the star of the team. We put her on creatine, some amino acids, but this was the only thing, she practiced and trained with a lot of other things but she ended up finishing 100 meters [unintelligible [01:04:14] in Pennsylvania, six in the entire state of Pennsylvania. So, was it creatine? No, not alone, but did that help? Yeah, I bet you that helped.

Cynthia Thurlow: That's an incredible story. I think it's important for people understand that the average person listening could probably get away with 3 grams per day. Like Scott mentioned, his daughter's a Division I athlete, totally different. Needs based on research that we looked at, the vegetarians and vegans need probably 5 grams a day. And so just understanding that very athletic people, and by that, I mean ultra-level conditioned athletes. I'm not talking about person who does CrossFit twice a week. Although that's great, you're probably not the person that needs that high amount of creatine. And also, it's interesting depending on where a woman is in her menstrual cycle, she may need more or less. But we didn't want to get terribly nuanced about that because there're so many other factors that impact hormone regulation and insulin sensitivity throughout a menstrual cycle. But just understanding that 3 grams a day has been our recommended for the average person that includes myself. But certainly, if I were giving this to my very athletic, sports-oriented kiddos, it would probably be more because they're still growing.

And, obviously, if you are vegetarian or vegan, your creatine needs, because you're not eating animal-based food or products, is going to be higher. And what was interesting, and I just want to make sure I'd dovetail this into our discussion about vegetarianism and veganism, is that it was even discussed in some of the research that their needs for creatine just based on brain health or even higher because they're not getting those animal-based products. And we respect people's choices. I just wanted to make sure I mentioned that they have to take more creatine to ward off the brain health related concerns.

Scott Emmens: Yeah, absolutely. I think we all make our individual choices. We obviously respect those choices. But it is important for people to know when they make any choice, whether it's to eat meat, what those risks are, or to not eat meat, what that diet will require you to do. Like we know, most vegans know that vitamin B12 is an essential supplement. I would put creatine in that same bucket. If I were vegan, there's no question I'll be taking creatine. I take it anyway I'm not eating because I know I'm excreting a little more than I'm taking in. I can feel the difference. But for sure, if you're vegan, you're going to want to, at the very least you do some research on your own, talking to physician or a functional medicine specialist, and I think you'll find that creatine will be a great addition to your diet.

Cynthia Thurlow: Absolutely. Well, I want to make sure I'm respectful of your time because I know that you have a lot going on as well. This has been an incredible podcast. I hope listeners find it to be just super information savvy. A few things for listeners before we go. If you'd like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can follow us on Instagram, we are @ifpodcast, I am @cynthia_thurlow_, Scott is @longevityprotocol, and MD Logic is @mdlogichealth. The show notes for today's episode that will have a full transcript as well as links to everything that we've talked about will be at ifpodcast.com/episode292. You can get all the stuff that we like at ifpodcast.com/stuffwelike.

This has been wonderful, and we will see you next week. And before we go, I wanted to make sure that I also included the link to get on the waitlist for my creatine. It's cynthiathurlow.com/new-shop/creatine. Gosh, that wasn't made easy, was it? Got to make things complicated. I'll tell my team make it easier next time. Scott, is there anything that you want to add before we go?

Scott Emmens: Well, yes, I would like to add that I have your updated information and the product by the time this airs, I think is November 21st, that the creatine will be available for purchase on November 21st. So, if you are not on the list already, you can order. It should be able to be ordered through your site, Cynthia, on November 21st.

Cynthia Thurlow: That's super exciting. I feel like this has been many months coming to fruition and I can't wait to share with the listeners the next product we're going to be working on.

Scott Emmens: I can't wait either. This has been great. Thank you so much for having me, Cynthia.

Cynthia Thurlow: Awesome. This has been so wonderful, and we will see you next week.

Scott Emmens: All right. Take care.

Melanie Avalon: Thank you so much for listening to The Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team. Administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs. And original theme composed by Leland Cox and recomposed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription] 

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Nov 13

Episode 291: Meat Intolerance, Generic Medications, Micronutrient Testing, Apple Cider Vinegar, Bone Broth Fasting, Grass Fed Butter, Ghee, And More!

Intermittent Fasting

Welcome to Episode 291 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get Two, 10 Oz Ribeyes FREE In Every Box For A Whole Year When You Join Plus An Additional $10 Off!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

Get $30 Off A CGM Subscription At Nutrisense.Io/Ifpodcast With The Code IFPODCAST

Introducing... Creatine By Cynthia Thurlow

Melanie: How She Grew

Cynthia: How She Grew

BON CHARGE: Go To boncharge.com And Use Coupon Code IFPODCAST To Save 15%

Listener Q&A: Linsey - Opening your eating window at different times.

Early Vs Late-Night Eating: Contradictions, Confusions, And Clarity

Listener Q&A: Tammy - Meat Intolerance

Listener Q&A: Tricia - Generic Medications

Vibrant America

Genova Diagnostics

SpectraCell Laboratories

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FEALS: Go To feals.com/ifpodcast To Become A Member And Get 50% Off Your First Order, With Free Shipping!

Listener Q&A: Angela - ACV mid fast drink - Thomas Delauer

Listener Q&A: Heather - IF... 12-18 hours

Go To melanieavalon.com/broth To Get 15% Off Any Order With The Code MelanieAvalon!

Listener Q&A: Taylor - Butter?

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 291 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time and get ready for The Intermittent Fasting Podcast.

Hi, friends, I'm about to tell you how to get free grass-fed, grass-finished ribeyes for a year plus $10 off? Yes, that's free grass-fed grass-finished ribeyes for a year plus $10 off. So we are huge fans around here of a company called ButcherBox. They deliver 100% grass-fed, grass-finished beef, free range organic chicken, heritage breed pork that's really hard to find by the way and wild-caught sustainable and responsible seafood shipped directly to your door. When you become a member you're joining a community focused on doing what's better for everyone. That includes caring about the lives of animals, the livelihoods of farmers, treating our planet with respect, and enjoying deliciously better meals together. There is a lot of confusion out there when it comes to transparency regarding grazing practices, what is actually in our food, how animals are being treated. I did so much research on ButcherBox. All of their beef is 100% grass-fed and grass-finished. That's really hard to find and friends you can taste the difference in their beef and steaks. I am a steak girl. I love steak. I've been eating a lot of ButcherBox steaks recently and I can promise you they are some of the most delicious steaks I've ever had in my entire life. And they work personally with all the farmers to truly support the regenerative agriculture system. This is so important to me. The value is incredible. The average cost is actually less than $6 per meal. And it's so easy, everything is shipped directly to your door. And this Black Friday your search for amazing deals on high-quality protein ends with ButcherBox. ButcherBox is offering our listeners one of their best steak deals ever. You can get free grass-fed ribeyes for a year plus $10 off, yes, that is two 10-ounce grass-fed ribeyes free in every box for an entire year when you join plus an additional $10 off. Sign up today at butcherbox.com/ifpodcast and use the coupon code IFPODCAST to get those free ribeyes for a year plus $10 off. That's butcherbox.com/ifpodcast and use code IFPODCAST to get the special Black Friday deal. Friends do not miss this and we'll put all this information in the show notes.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream. And then in our bodies, studies have shown they do things reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup maybe playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because, ladies, when we have babies, a huge percent of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years. 

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later, maybe half of that lead has left your bones. On top of that there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so, you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life. And their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey, even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out. You can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well.

And lastly, if you're thinking of making Clean Beauty and Safe Skincare, a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like the Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally, completely worth it. So, again, to shop with us, go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now, back to the show.

Melanie Avalon: Hi, everybody, and welcome. This is episode number 291 of The Intermittent Fasting Podcast. I'm Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hi, Melanie.

Melanie Avalon: How are you today Cynthia?

Cynthia Thurlow: I'm definitely having one of those days where there's a lot of really great things that are ongoing, but I feel a little overwhelmed.

Melanie Avalon: Well, that definitely makes you relatable to probably a lot of people. So, in general, how often are you-- in your life how often do you oscillate between feeling overwhelmed and feeling not overwhelmed?

Cynthia Thurlow: Probably a daily basis because there are so many things that are at play, being a mom and solo parenting this week and running a business and I've got a dog that's got a digestive issue. And so, today's definitely one of those days, I'm like okay, we can do it, we can totally do it. So, I have to psych myself out. But I would say as an entrepreneur, I think there's almost every day, I have a moment where I'm like I don't know how I'm going to do all this, but it's going to happen. How about you?

Melanie Avalon: Yeah, I was just thinking about how, it's interesting how people can be so different with their psychology of how they approach planning out their life or not planning and dealing with that, because for me as long as I really plan everything, I feel safe and my ability to do everything, but I was just thinking about how some people, get really overwhelmed at the thought of planning things out. And so, it's just really interesting concept to think about. My calendar looks really intense if you look at it, but that's my safety net, knowing everything is scheduled and has a place and a time and honoring it. 

Cynthia Thurlow: Yeah, I think it's the idiosyncrasies of life. When things that are not planned pop up, then you're "Okay, how do I roll with it," I think years of working in an ER and working in more acutely sick environments. If I was calm, everyone around me could be calm. And so, I may not look stressed, but internally, I'm like "Okay, what do we need to do?" I usually plan out my days. And I'm like "Okay, the big hump of the day is here and once I've done that, then things will be easier." And so, I just got over my big hump, so everything else today is going to be on downhill, so it'll be good.

Melanie Avalon: Awesome. Yeah, for me, I have to really really honor all of my daily self-care things and my sleep. And I really have to prioritize that. And it took a while to reframe that is not being selfish [laughs] because taking care of yourself. But I do think it's just so important, and the way that you can show up for everybody else in your life.

Cynthia Thurlow: Yeah, and I think a lot of women have to give themselves permission to acknowledge that having boundaries and prioritizing self-care and that could look different for every person is really helpful. I know for me there are certain things I have to do in the morning to get my day started that allow me to feel I'm relaxed and I'm ready, and I can give 100% to whatever I'm doing. But I don't-- as an example, I'm not someone who likes to wake up late. So, if I've set my alarm and I sleep through an alarm, which occasionally happens, I have to reframe my morning because I then don't have the luxury of being able to do the things I need to do normally. But thankfully, that doesn't happen very often.

Melanie Avalon: It's so funny because I'm obviously the opposite. If I get up early, it throws me all off [laughs]. So, everybody's definitely unique.

Cynthia Thurlow: Um-hmm.

Melanie Avalon: So, I have two quick fun announcements for people to share. One, so this episode airs midway through November. And we don't have the exact date yet. But we're hoping planning to release my berberine supplement at the very beginning of December, so it might be two weeks away when this airs. It's been really exciting because berberine is something I've been taking every day for a long time it has really beneficial effects on blood sugar levels, which is why I started taking it while wearing a CGM, NutriSense by the way, we can put a link in the show notes to a code for them. Actually, I should just say it, because I know people don't check the show notes. Oh, that's a thing in the Facebook group the other day, people will still comment and not realize that we have transcripts for this show. So yes, there are transcripts if you go to the show notes at ifpodcast.com/episode291. So, the NutriSense CGM code is nutrisense.io/ifpodcast. And I think if it's a coupon code, it's IFPODCAST for a discount. Meandering way to say I always have seen beneficial effects on my blood sugar levels from berberine. And it's been exciting because I've been researching other topics and it keeps popping up and I don't know if that's just because I'm manifesting it or looking for it. I think last week, we talked about its role in autophagy and then I'm prepping to interview Dr. Heather Moday right now. She has a book all about the immune system, she had a section on it. So, it can really be a beneficial compound that I think a lot of people might benefit from bringing into their life. And so, if you've enjoyed my serrapeptase and magnesium, that is coming up next. So to get the information, because we will definitely be doing a launch special. You can get on the email list at avalonx.us/emaillist. And you can get text updates if you text AvalonX to 877-861-8318. Are you setting up an email list for your supplement line, Cynthia?

Cynthia Thurlow: Yes, and it should be out basically we're told by mid-November. I don't have a date yet, but it'll definitely be out before Thanksgiving. And yes, we do have, we'll put a link in the show notes to the creatine weightless page, which you'll be made aware of when it goes live and is available for purchase.

Melanie Avalon: Awesome, so wow, mid-November. When this is airing, it might actually be out or almost out, that's very exciting.

Cynthia Thurlow: Yeah, I'm super excited. I feel it's been a long process, but one that I feel really comfortable. I think it's a supplement that will certainly help people enormously. I don't think a lot of people realize what all goes into-- "Well, I don't want to make assumptions." But a lot goes into making these like my serrapeptase. I first met our partner Scott in April of 2021. And we launched it in that November. So, half a year, so much goes into it, but it's really, really, exciting. So, good things are coming. The other baby announcement I have is I've been talking a lot about launching an EMF-blocking product line. And so, I'm still working on the device that you will put on your bed stand to protect yourself from EMF from your phone at night and still letting you charge your phone and keep your phone not in airplane mode because I know it can be important to receive calls and such. So that is coming soon, we're working on it actually, the process that we're at right now is like renders of the models and prototypes and things that. In the meantime, I might actually just go ahead and launch the line, just to get it going with something that I use every day, I'm using right now actually, which are EMF-blocking headphones. So, basically, when I see people using, I mean not even just normal headphones but using AirPods, I just shudder thinking about the effects that might be having on our brain, which I know people think it is woo-woo sometimes, but there are a lot of studies on the effects of EMFs on the calcium channels and health and it's even considered a carcinogen by one of the World Health Organizations. So yes, if you want EMF-blocking headsets, stay tuned that's coming. I should probably set up an email list for that as well, but just putting it out there.

Cynthia Thurlow: It's so exciting.

Melanie Avalon: Anything new in your world?

Cynthia Thurlow: Goodness, I think a lot of what's new in my world is navigating business travel and trying to run a business. And so, next week, I'm going to be in Chicago. I'm not speaking in Chicago, I'm attending an event. And then we just planned out LA travel. And I picked up another podcast while I'm out there. So, I'm trying to figure out how to fit all these things together and to do so gracefully and with incredible gratitude and just savor a very exciting time. So, I would say the big things for me right now we're just trying to figure out how to make all these things work, and still celebrate holidays and be fully present for my family and be 100% present in my business. And the challenges of being an entrepreneur it's wonderful, but you have moments where you're trying to drink from a fire hydrant, there's just so much. It's like okay, let's just try to focus on all the wonderful things and processing and all of that.

Melanie Avalon: Which actually, I wonder if it'll still be available when this airs, we should plug our How We Grew Summit that both you and I did, which Cynthia and I were both guests in a Summit hosted by my good friend Noelle Tarr, also Liz Wolfe and I think three other women. So, it's a collection of interviews, that's a lot of interviews with all female entrepreneurs and how they're doing what they're doing. Last night, I was listening to Noelle had Liz on her podcast and they were just having a conversation and talking a little bit about it. And I was like man, I need to actually listen to all these interviews. I feel there's so much to learn from incredible women that are doing great things with their own businesses and such. We both have links for that, it's both of our websites, so melanieavalon.com/howshegrew and cynthiathurlow.com/howshegrew is the link for that if women would to learn more.

Cynthia Thurlow: Did I ever tell you the connection for me to Liz Wolfe?

Melanie Avalon: No.

Cynthia Thurlow: I read her book, Eat the Yolks and reached out to her and said where did you get your training? And she responded the same day. And I told her when we were interviewing, I said, I really credit you with helping the trajectory and the changes that I made in my business. And I'm so grateful to be able to give back because first of all I was stunned that she responded and then second of all, reading her book really was instrumental in setting the path in motion for me to dive into the functional space, and on a lot of levels like really changed everything I was doing. So, I was so happy to participate because she had in some small way contributed to the massive shift I did.

Melanie Avalon: I did not know that. It's funny, I feel like I know her because I talk to Noelle all the time and Noelle always talking about Liz and you know Liz. Yeah, I've never actually met her.

Cynthia Thurlow: She's lovely and I like that she's a little snarky and I can be a little snarky. And so, I appreciate that, when I see that in other women and it's not in a way that's meant to be hurtful. It's just funny and you're not hurting anyone. You just speak your mind, which I love.

Melanie Avalon: Awesome, so yep, listeners can definitely check all that out.

Hi friends. I'm about to tell you how to get 15% off my favorite blue-light blocking glasses ever. So, I am often asked what are my favorite "biohacking products?" And something I truly, honestly cannot imagine my life without are blue-light blocking glasses. So, in today's modern environment, we are massively overexposed to blue light. It's a stimulating type of light, which can lead to stress, anxiety, headaches, and in particular sleep issues. Blue light actually stops our bodies from producing melatonin, which is our sleep hormone. So, our exposure to blue light can completely disrupt our circadian rhythm, make it hard to fall asleep, make it hard to stay asleep and so much more. Friends, I identify as an insomniac, I would not be able to sleep without my blue-light blocking glasses. I also stay up late working and wearing blue-light blocking glasses at night has made it so I can do that and still fall asleep. My absolute favorite blue-light blocking glasses on the market are Bon Charge, formerly known as BLUblox.

Bon Charge makes an array of blue-light blocking glasses in all different designs, so you can truly find something that fits your style and reap all of the benefits of blue-light blocking. They have their clear computer glasses. You can wear those during the day, especially if you're looking at screens all day to help with anxiety, headaches, and stress. They have their light sensitivity glasses, those are tinged with a special yellow color scientifically proven to boost mood, and they block even more blue light. Those are great for the day or evening. Then they have their blue-light blocking glasses for sleep. Those are the ones that I put on at night while working before bed. Oh, my goodness, friends, it's something you truly have to experience. You put on these glasses and it's like you just tell your brain, “Okay, it's time to go to sleep soon.” They also have amazing blackout sleep masks, those block 100% of light with zero eye pressure. I wear this every single night and I don't know how I would sleep without it. And you can get 15% off sitewide. Just go to boncharge.com and use the coupon code IFPODCAST to save 15%. That's B-O-N-C-H-A-R-G-E dotcom with the coupon code IFPODCAST to save 15%. All right now back to the show.

Melanie Avalon: Shall we jump into some questions for today?

Cynthia Thurlow: Absolutely.

Melanie Avalon: So to start things off, we have a question from Lindsey. The subject is "Opening your eating window at different times." And Lindsey says, "Hey there, I've been soaking up all things IF in the last couple months and I have to say your podcast is a great resource when it comes to navigating this newly found lifestyle of mine. I'm about a month into a 4:3 protocol and I'm already enjoying the weight loss benefits while learning what works best for my body. Eventually, I'd like to switch to one-meal-a-day window because mentally and socially I think it will be easier to stick to long term. Right now, I notice how lethargic I feel after lunch on my eating days. So, a daily dinner time window of about three hours is what I would like to transition to in the future. I'm curious about something though and wonder if either of you have ever experimented with this. If you change your eating window, start time from day to day while still keeping the amount of hours you eat consistent, will it dramatically affect the benefits of fasting both health-wise and weight loss-wise. I work in a small closeknit office where we have a delicious healthy lunch prepared for us daily free of charge. I'm friends with a lot of people at work. So, it's nice to eat lunch with them sometimes during the week. It's also nice on my wallet to get a free healthy meal here and there. Let's say twice a week I open my eating window from noon to 3:00 PM and the rest of the week I stick to an evening window of 5:00 to 8:00 PM. Will the earlier eating window a couple of times a week become a major roadblock in my fasting success? Thank you for passing along all your fasting knowledge and helping others along the way."

Cynthia Thurlow: Well, Lindsey, thank you for the great question. I would say how nice it is that your workplace is offering up a healthy lunch. I think you're probably in the minority. If there are lunches provided, they generally tend to not be particularly healthy. So, there are a couple of things to unpack in this question. First and foremost, I don't know your age. But certainly, I do think some degree of variability of fasting windows is something that I myself am a proponent of. My concern is if you're only eating one meal a day that you will get into a position where you are going to not be consuming enough protein, which can potentially contribute to many things, but can contribute to muscle loss. And so, I think from my perspective, I just want to make sure I fully understand the question. I do think that when we eat earlier in the day, we tend to be more insulin sensitive. When we're eating in the evening, we can become or potentially become more insulin resistant. We know that we just have better insulin sensitivity earlier in the day. So, I think from my perspective, I would just be cautious about wanting to do an OMAD situation every single day. If you alternate between two meals versus one that might be some degree of variability. I see a lot of people doing 30/16, where they'll do 30 hours fasted and then eat and then have a 16-hour period of time in which they're not eating. But I would just be certainly careful about just having a very narrow eating window day to day, week to week because that could potentially set you up for slowing your metabolism. And that's something just to keep in mind. Melanie, how would you address this, because I know that you are my unicorn friend and you eat in the evening and go to bed late. And that works for you and you're very metabolically healthy. So, I think that's something to stress. This is where bio-individuality really is very, very important.

Melanie Avalon: I think I've mentioned this article a lot before but I wrote a blog post called Early Versus Late-Night Eating: Contradictions, Confusion, and Clarity. I'll put a link to in the show notes. The link for it is actually melanieavalon.com/eatingtiming. With that article or that blog I tried really hard to objectively non-bias look at all of the literature on eating timing and how it affects things and one of the most-- what would be a good word? Clouding things about it all is that the majority of studies looking at later evening are looking at it in the context of also eating earlier, compared to fasting all day and then eating later which can potentially see a different effect than if you had been eating even just a little bit earlier in the day.

My takeaway when I was reading it was if I had to pick a perfect window, even granted the fact that people are bio-individual but just looking at it, it seemed that around 4:00 to 7:00 ish hormonally seem to be the best, but that's not a blanket statement and everybody is individual, of course. But speaking to the switching it up, I'm totally down with people switching things up. And the thing that obviously-- maybe this isn't obvious, but if you switch it up, then you will naturally have-- assuming you maintain the same eating window, you will naturally have some shorter fast and then some longer fast as well. As far as the actual fast, I don't see it as a roadblock. I agree 100% with Cynthia about making sure you're getting enough protein in that window. Especially if you're-- well, I know for me when I'm eating late at night, I'm eating a ton of protein. And it's easy to do because I just buy it all myself and I have it. If I were to eat out, it's hard for me to get enough protein, I would not be able to eat out. I know she's talking about eating at work, but I wouldn't be able to do a restaurant meal and a one-meal-a-day situation every night, I just wouldn't be able to get enough protein. And when I do get restaurant meals, I normally get protein as dessert. Have I talked about that on here, Cynthia?

Cynthia Thurlow: I don't think so.

Melanie Avalon: So, yes, my family or whoever I'm with will usually get a dessert and I'll usually get a second round of the appetizer if it was Sashimi or Carpaccio, and I went to a restaurant actually a few weeks ago and ordered that. And I was like "Has anybody ever done that before?" And you said yeah, people do order "Home savory desserts," so I felt better. So, just a fun fact, you can always order if you're not eating dessert, you can order another round of salmon. But in any case, yes, I would focus on making sure you're getting enough protein. I wouldn't stress about the hours being different. And I'm actually jealous almost of people that can mix it up like that, because I think some people can really well and I think some people struggle a little bit. I have tried in the past to change things up and eat earlier and it does not go well. It's just operation fail and Gin was the same way as well. We have this in common. We both found that she did one-meal-a-day evening window earlier than mine, but we both had the experience where if we were to open our window earlier, we could eat, we could feel good. And then come dinner we would have the exact same signaling and appetite and just rinse and repeat. So, I'm not the type of person that could eat earlier and be done. I'll be starving again at night. So, yeah.

Cynthia Thurlow: I think that's the beauty of bio-individuality. It's figuring out what works best for us and leaning into it without apologies.

Melanie Avalon: Yes, exactly for me I just love going to bed on a full stomach and one of the things I disliked growing up when I would try to be dieting was that whole don't eat three hours before bed thing. I would try to do that and that was so miserable. I so disliked that. One of the things I love best about the fasting situation for me now is that I can just go to bed really full and happy which is actually going to relate a little bit to our next question. Shall we go to that one?

Cynthia Thurlow: Absolutely. This is from Tammy. Subject is "Meat intolerance." "Hey, ladies, the only thing I enjoy about Monday mornings, lol. I've always thought that eating meat didn't agree with me. I've never felt wonderful after a meal with meat. But always ate it because I thought we were supposed to. Well, since I started Intermittent Fasting last March, I've noticed lately that I feel tired, almost lethargic after eating a meal with meat. The other night I baked chicken. I couldn't hold my eyes open and just had to lie down. If I have a meatless meal, I'm perfectly fine. So, is this something you've heard of? I've seen people in the Facebook group mention they are tired after eating and even mention they eat just before bed because they are so tired. Because my body is sending me these signals."

Melanie Avalon: Awesome, Tammy. So, I have the date of when this question came in and this question is actually four years old. So that's just to inspire people if you submitted a question a long time ago, keep listening because we might answer it because sometimes I-- especially when I'm trying to create variety on the show with a question, sometimes I go way back in the archives. So Tammy, if you're still with us, let us know if you're still with us I'd actually be really curious. So, this question is interesting. So, the times when I would experiment with opening my window early. If I were to do like Tammy said and not have meat, so have just fruit or something like that I would not get tired, but if I were to eat protein and meat during the day, I get super tired and I don't-- "Well, I guess I do notice it at night. It's very conducive to my sleep at night because I do get tired and I find it really helps me sleep." And what I think is going on here, well a few things. So, I have a general answer and then I have a Tammy-specific answer. The general answer is that protein requires a lot of energy to digest. So, it has the highest thermogenic effect of any food, it's estimated and this is just an estimation, but around 30% of the calories from protein might actually be required to actually digest it. So, yes, that can make people tired and this is just my theory, I haven't read this anywhere. But it makes a lot of sense in my head.

My theory is that-- so if you're eating smaller meals throughout the day, you're not getting that big of a shift as much between sympathetic and parasympathetic, basically, the two types of the nervous system like the energetic, fight or flight, norepinephrine, epinephrine, hormones like that state and then the parasympathetic, so the rest, the digest, the relaxation, and I think when people are doing fasting, especially if they're doing a long fast and then this meal, I feel it makes it much more evident that switch from sympathetic to parasympathetic. And I think it probably hits people harder and makes them sleepier and then on top of that they're probably eating more because they are eating in smaller eating window. So, that's my theory about what's going on there. Because even for me, before fasting when I was eating throughout the day, I wouldn't fall asleep after a meal. I mean maybe on occasion, but I didn't get that response compared to now if I were to eat during the day, I would like want to take a nap. My Tammy-specific answer is I find it really interesting that meat didn't agree with you that you've never felt good after me and I wonder what's going on there. So, is it a specific type of meat? Is it a food sensitivity? Or is it that you don't digest? Maybe you need more stomach acid, so maybe taking a HCl supplement or something like that might help.

But the fact that you've always had issues with meat, it doesn't surprise me that you have an even more intense response to it now. And then just one last little piece, the concept of you ate meat because you thought we were supposed to. So, that's a loaded thought or statement. And I like to think that I'm diet agnostic. I really do think when you take a whole foods approach, you probably can make most approaches work if you try really, really hard, so I think for most people a meatless approach, a 100% vegan, plant based meatless approach. Most people I don't think will thrive on that and would need to take concentrated efforts to make sure they're getting enough protein, enough nutrients that they're missing. Whereas you could have even just adding a little bit of meat, get some of those nutrients and protein that you might be missing. And I'm actually really excited because-- and I'm sorry I'm going on so many tangents.

So, I just started reading Megan Rossi's book last night, she calls herself the gut health doctor. So, her first book is called Love Your Gut: Supercharge Your Digestive Health and Transform Your Well-Being from the Inside Out. And her new book is called How to Eat More Plants: Transform Your Health with 30 Plant-Based Foods Per Week (and Why It's Easier Than You Think). And I literally just started it, but what I'm really excited about is a large portion of the beginning of it she is talking about how-- she's actually not-- even though she's known as a plant-based figure that she's not even necessarily advocating going 100% plant-based approach, and she talks about how, if you actually look at the studies, it seems that nutritionally for most people having a little bit of meat is probably a good thing. And she references, I got to look it up. But she said there's a new study that came out.

So researchers from 16 countries looked at 1000s of scientific papers. And they came up with a "planetary health diet." That establishes a universally healthy reference diet that takes into account nutritional needs, overall health of humans and the environment, and long-term sustainability, and it is inclusive of animal foods. And the reason I'm bringing that up is there is this idea that people feel like, well, it's funny because people feel they should not eat meat like that's what they're supposed to do. So, I find it really interesting that some people think that and some people think that they should eat meat. I would step outside of the framing of what you should or shouldn't do or what goes back to bio-individuality, like what everybody should do and instead what should you do and what are your needs. So, that was a little bit of an esoteric tangent, but Cynthia, what are your thoughts?

Cynthia Thurlow: The first thing I think about is, if you're tired after a meal, I always think about blood sugar. I don't know if Tammy has checked her blood sugar, pre-meal and post-meal to see what it's doing, certainly if she was eating a carbohydrate bolus that would be much more suggestive of a potential blood sugar dysregulation. But quite honestly, this is where bio-individuality really is important. I don't at all question what she's experiencing is absolutely real. But I think I'd more information, I'd really to know what her blood sugar's doing that is precipitating that degree of fatigue. And, we tend to be more insulin resistant as the day goes on. And obviously, life stage plays a role. I don't know, Tammy's age or what life stage she is in. Generally, in your 20s and 30s, you're much more buoyantly insulin sensitive, largely is a byproduct of that degree of muscle mass that you maintain at that stage. So, there is a lot of things that could be going on. But I think the starting point for me would be to get a glucometer where I have a CGM so that you can monitor what her blood sugar's doing.

Melanie Avalon: So glad you brought that up and that's something that I need to remember more. I need to get outside of my own experience of it. Because my experience typically with blood sugar swings, when I would have them, what I would tend to get either reactive hypoglycemic or basically presenting as reactive hypoglycemia, but actually not having low blood sugar. And the response to me has always been an adrenaline boost or epinephrine. So, I get awake from that. And I forget that for a lot of people, they get that crash. So, the fact that she does not have that experience, though, after a meatless meal, just makes me think it may be more about the actual protein digestion, but it's hard to know, I would definitely suggest trying some HCl supplements that might help which is something I do plan to make in the future. In the meantime, I take Pure Encapsulations, I really their brand.

So, we have a question from Trisha. The subject is "Generic medicine." And Trisha says, "Good morning. I was listening this morning and I was so happy to hear Cynthia speak about fillers and inconsistency in generic medications. I recently experienced this myself, I take bi-thyroid." What is bi-thyroid? Do you know?

Cynthia Thurlow: I'm not familiar with that. I don't know bi-thyroid. I don't know if that means that she gets T4 and T3.

Melanie Avalon: Bioidentical thyroid, maybe?

Cynthia Thurlow: I've never heard it describe that one.

Melanie Avalon: And with it, she takes extra T3 from a pharmacy. What's really interesting is that's what I do. I take compounded thyroid with extra T3. She says, "This has served me well for some time. I noticed with this last batch I started having bloat, gas, and terrible stomach pains. The only thing I could trace it back to was the T3. I looked up at the ingredients and it has mannitol in it. I have terrible reactions to sugar alcohols. I spoke with my wonderful pharmacist and his ingredient list didn't have mannitol in it. However, he said generic meds are very inconsistent. And so, we highly recommended I have the T3 compounded. So, I did and although it is terribly expensive, my symptoms disappeared. Another issue I have is maltodextrin. I can't believe how many generic meds and supplements use that filler. I have even worse reactions to maltodextrin; swelling, gas, heart palpitations, irritability, etc. I check the ingredients on every label now. I take LDN for Hashimoto's. And I have to have it compounded in Colorado because they're the only ones who make it in pill form with no fillers." By the way, Trisha I take LDN as well, we're so similar. "I used to think I was crazy, but the body doesn't lie. I have IBS-C," me too Trisha. "And I'm super sensitive to many things. I recently realized that lactose bothers me as well. I've been IF'ing for years for health, but I think it also helps my gut? She says, "I wanted to ask if you think it's beneficial to have my nutrients tested. I'm not sure what the test is called, but it's a blood test that is comprehensive and can tell you what you are deficient in and what supplements you need. If this is helpful, would you please suggest a company that will follow through with the results? I'm meeting with my doctor to go over my genetic test. So, do you think that will be enough? I'm 61, really healthy except for gut issues that I've suffered with my whole life. I take supplements from Dr. Gundry, that seemed to help but would really to fix this once and for all." Thank you both for all you do to help us.

Cynthia Thurlow: Well, Trisha, I'm so grateful that you're putting those pieces together for yourself. And it's not at all uncommon for there to be tremendous variability in batches of medications, especially generic ones. In fact, now I take all compounded medications, both thyroid, progesterone and testosterone. And to be completely fair, I think it's the first time on my thyroid medication in two years where I'm feeling probably somewhat like I used to feel. So, I applaud you that you have a provider and a pharmacist that are open to helping support your needs and certainly sensitive to the fact that you are sensitive to these fillers. In terms of nutrient testing, I really like Genova's NutrEval. But you actually have to go through very likely a functional or integrative medicine healthcare professional to review the testing. You can't just order it by yourself and as far as I know, at this point in time Genova is not providing testing results to patients directly that you have to go through a provider and the provider would then review the testing with you. But I think that's probably the best one in the market that I've seen. I did that a few years ago, one of my children's also done it and it was very, very insightful.

Melanie Avalon: Awesome, it's so interesting. I'm actually really torn about the compounded situation. I get all of my meds compounded. I really the pharmacy that I work with and like you said, Cynthia, I think it's really important to find a pharmacy that you can work with that you trust. The reason I'm torn about it is I've had a lot of conversations with Dr. Alan Christianson, and he makes the case that the-- so. not generic, but the non-generic, the official form of everything has much more regulation than obviously a compounded pharmacy where there's, it's self-regulating, there's a book about compounded medication-- I don't want to scare people. But there's a book out there about compounded medication like errors that have happened. So, not to be a negative Nancy. And I said, I get all compounded medication myself, but I just think it's really important to well, two things to take away from this one. Like I said, finding a pharmacy you trust and two, like you were Trisha, being intuitive with yourself and if something seems off looking more into it. So, I really applaud you for that. As far as the test, I was going to be really curious what you said. So, that's a good resource to know. Have you heard of-- one that I've seen pop up on a lot of people that I've interviewed and that Heather Moday, The Immunotype-- book that I'm reading, she listed two tests, and one of them is one I keep hearing about, have you done SpectraCell?

Cynthia Thurlow: No, I have not.

Melanie Avalon: Okay, that's what I've heard from multiple people that I've interviewed. So, I think I haven't done it, but it might be a good resource. It's spectracell.com. And then the other one she listed, which I hadn't heard of before, so I take it with a grain of salt, but it's called Vibrant America. So, I'll put links to both of those and the Genova one in the show notes. I do wish that was something that was more easily accessible for people.

Cynthia Thurlow: Well, I think the problem as a provider, I understand as a consumer wanting to have access to that type of testing, but it also sets up if there's an abnormality, I mean, the testing company could be held liable. So, you have to do it through a practitioner so that the practitioner reviews the results with the patient. And, I admittedly it's not a test that I ordered in my clinical practice. It's just one that I have working knowledge of. Genova has really high-quality testing modalities and so that's the one that I'm most familiarized with.

Melanie Avalon: Awesome. I think it was Dr. Anthony Beck that I had on that was also talking about SpectraCell, and maybe I know it's come up quite a few times. So, we'll put links to that and the Genova test.

Cynthia Thurlow: Awesome.

Melanie Avalon: I will put out one more resource. It's not a full spectrum micronutrient testing, but let's get checked, they do have some specific micronutrients that you can test and we have a code for them, so I can double-check it. You can always go to ifpodcast.com/stuffwelike to see a lot of the stuff that we like and I'm just noticing how I need to update this page. If you go to-- hopefully this is still active. Try lgc.com/ifpodcasts and the coupon code IFPODCAST30 should get you 30% off.

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Melanie Avalon: Okay, shall we go on to our next question?

Cynthia Thurlow: Absolutely. This is from Angela. Subject is "Apple cider vinegar mid-fast drink. Thomas DeLauer." "Hello, I was wondering your opinion on drinking apple cider vinegar mid-fast. I listened to a YouTube video from Thomas DeLauer and he talks about drinking a drink made up of eight ounces of water, apple cider vinegar, pink Himalayan salt and cream of tartar, mid-fast or an hour or two before opening your window. I do the clean fast, strictly water and black coffee. But according to him this drink helps you retain minerals, and helps to get the most out of your fast. I decided to drink this one hour before opening my fast and I noticed that also curb my appetite and I was able to wait longer to open my window food-wise. What is your opinion on this? I love your podcast and you helped me stay motivated." Thank you.

Melanie Avalon: Awesome. Thank you for your question, Angela. I had Thomas booked for the show and it fell through and we haven't rescheduled it. So, I'm going to email him after this. So, my thoughts I do consider apple cider vinegar. I know a lot of people like Thomas and others advocate it during the fast. I do consider breaking the fast especially because it can stimulate digestion. Although it is interesting that it curbs your appetite and people do experience that as well. I would err on the side of having this right before eating as a way to prepare yourself for food. That said, I'm also for if you're doing it-- like I'm not the fasting police. If you're doing it and you like it, and it's working for you. I mean, just do it. I'm not so intense with people. I think it's less of an issue when it's like this where it's closer to the end of your fast, mid-fast I might be a little bit more suspicious but an hour or so before eating and you're enjoying it, I think it's fine. And even mid-fast and you're doing it and you're enjoying it, people you can do what you want. It's when things are not working that you might want to reconsider. What are your thoughts?

Cynthia Thurlow: Well, I love Thomas, I've been a guest of his twice on his YouTube channel. And I think the world of him he's super smart and generally speaking, he's really well steeped in the research. I can tell you when I wrote the book, apple cider vinegar without the mother, so not the Bragg's variety that has protein in it, but the filtered apple cider vinegar, which I don't know anyone would buy that but that's a whole separate conversation, will technically not break a fast. However, we're talking about a clean fast water apple cider vinegar from my perspective, pink Himalayan salt is probably fine. I don't know enough about cream of tartar, but I do know Thomas well enough to know he's very well researched and super smart. So, I think this really begs me to go check this out and learn more about it. He's so well-researched and so smart as I've said multiple times that this is a good instance where I would probably go watch the video and then pull up the research and take a look at it and there might be something that I'm unaware of but typically, apple cider vinegar without the mother is not going to break a clean fast, but we know that people take apple cider vinegar for a variety of reasons. Sometimes people take it pre-digestion to help with digestion. Some people use it to blunt blood sugar response and cravings and so I'm actually grateful that Angela asked this question because now I'm going to go down a rabbit hole when I'm done with this podcast recording today because I know I want to go look for this and see what I can learn. Yeah, I looked up cream of-- I always called the cream of tartar, but it probably is tartar. And it looks its obviously very minimal calories, but they are carb calories, whatever it is.

Cynthia Thurlow: I guess the retaining minerals part. I mean, that's the only thing I can think of is there something special about cream of tartar, I don't know. I'm a good baker, but I'm not down with all the chemistry behind baking.

Melanie Avalon: Yeah.

Cynthia Thurlow: I will reserve my opinion until I have done more research.

Melanie Avalon: Alright, so now we have a question from Heather. The subject is "IF 12 to 18 hours" and Heather says, "Hi, I wanted to fast yesterday from 3:00 PM to 11:00 PM 20 hours, but I got hungry last night around 10:00 PM and decided to have a bowl of chicken broth. I had coffee at 9:00 AM this morning. Did I make it so it was not beneficial to me? Or is that still a beneficial fast? I'm trying to heal leaky gut? I have a hard time going too long on a fast. Can I still benefit from shorter fast or fast that just allow bone broth? Hmm," that was her not me. What are your thoughts, Cynthia?

Cynthia Thurlow: I think there're a couple things that are going on. If we're talking about a clean fast, obviously, bone broth is a protein that technically breaks your fast. However, this is someone Heather mentions that she is struggling to go towards longer fasts and when we're thinking about leaky gut and helping to repair leaky gut, we don't want to overtly stress the body. So, my feeling is not to stress about this. We know that there are benefits from doing longer fasts in terms of stem cell activation and overall gut microbiota improvement. But if you're fairly new to fasting, and you're feeling you're struggling to do longer fasts, I would lean into what you're able to do with the understanding that you are-- it's like a fasting muscle, you're flexing your muscle, you're developing this fasting muscle so that you can then go on to fasting longer, but adding additional stress like worrying about, what did bone broth do? I mean some people will actually drink bone broth with longer fasts, A, because they get some electrolytes, but also provide some degree of nourishment. And they can sometimes do longer fasts that way. But I wouldn't let that be a deal breaker for you. I think we put enough pressure on ourselves in general that I would focus in on doing a successful fast, focusing on why you're doing it, and then if you're really focusing in on leaky gut, building that fasting muscle so that you can then ultimately go on to fast longer. What do you think, Melanie?

Melanie Avalon: I agree, 100%. And the only other thing I would add is-- and a lot of people are probably aware of this, but people may not be-- with the chicken broth or the bone broth. if you're making it yourself versus getting it at the store. If you're getting at the store look at the ingredient panel, you'd be so surprised how many of these broths have so much stuff in them that you don't want. So, try to find ones that are organic and very minimal ingredients, especially if it's in this, "Fasting type situation." And I think this is something where it's really important to have that come from good sourced meats and such. So, we love Beauty & the Broth. Those are shelf-stable, they come in packets, and you reconstitute it with water and it's organic and really delicious and we have a coupon code. So, if you go to melanieavalon.com/broth that will redirect to their website and the code MELANIEAVALON will actually get you 15% off any order, so that's a great option. Those were game changers for me when I was doing my colonoscopy prep and could only drink broth. Bonafide is another brand that I really at Whole Foods, it's frozen. So yes, just be careful to look at the ingredient lists.

Alright, so we have a question from Taylor. The subject is "Butter." And Taylor says, "I've been vegetarian for over 11 years and have been mostly vegan for the last year of that. I'm wondering what you think in regards to butter. I have been using earth balance buttery spread the organic version in place of the Kerrygold grass-fed butter I was using previously, but was just reading up on vegetable oils in The Obesity Code. I did generally feel better on a low to no dairy regimen, but I know that I would feel just as good as I do when I am dairy free if I was using a little butter. Do you think the grass-fed dairy or ghee would be healthier than the "natural flavors and vegetable oils and earth balance?" And then she lists the ingredients and it's stuff like natural oil blend with palm fruit, soybean, canola and olive oil, water, salt, less than 2% of natural flavor, dry form corn, soybeans, soy lecithin, I can never say that word, lactic acid and anatto for color." She says please let me know your thoughts as I'd be happy to switch if real grass-fed butter or ghee is a better health and weight management option. Thanks so much for everything you do.

Cynthia Thurlow: Well, Taylor that's a great question. I would say from my perspective that grass-fed butter or ghee is going to be a much healthier option than the earth balance buttery spread, which contains inflammatory seed oils in conjunction with olive oil. From my perspective, the inflammatory seed oils are really adulterated, oftentimes rancid? If you want to dive down a rabbit hole go Google what constitutes creating canola oil that will cure you have any desire to ever consume that again? So, from an inflammatory perspective and an anti-inflammatory perspective, I would absolutely lean into ghee, which is definitely better tolerated for those that are sensitive to dairy. I do find that many of my patients that also have dairy sensitivities do find with grass-fed butter, that you may want to experiment a bit. But I would definitely ditch the earth balance so that you can find a healthier option for you.

Melanie Avalon: I'm really happy that there's an increasing awareness and shift away I think from these products that are just full of so many ingredients that I think can often potentially be inflammatory. And even the natural flavor stuff, I've mentioned this a lot, but interviewing Mark Schatzker for his book, The Dorito Effect, and the End of Craving just really opened my eyes to the potential effects of these compounds on our health and wellness. So, I think grass-fed dairy and ghee can have a lot of amazing health benefits and work really well for people. I'm also not the person that says eat all the butter to lose weight, because I think people take things to the extreme, especially in the Keto world, but especially for Taylor, she wants to just add a little bit, I'm not saying adding a lot would be a problem, but the point that I'm saying is that I would definitely err on the side of grass-fed dairy and the ghee. And it's nice to hear that Cynthia about people's reactions with ghee specifically. Do you have any favorite brands?

Cynthia Thurlow: I would say Kerrygold and there are a couple of French butters that we get in our local Whole Foods, I can't remember the name, I can try to look them up. But those are-- they generally tend to be very rich, they don't need a lot of them. And I always buy salted butter, it does make a big difference. I'm a salt aficionado now, I'm obsessed with salt. I carry it with me when I travel too, which makes me sound a nut job. But with that being said, Kerrygold generally speaking is going to be high quality. If you lean into some of the European butters, they generally tend to be a higher fat content so they can be very rich. And so, you don't need as much of them. In terms of ghee brands. I really like 4th & Heart. They have a lot of variations. There's one that actually has Himalayan pink salt in it that we really like.

Melanie Avalon: Do they cater that in Whole Foods.

Cynthia Thurlow: Um-hmm.

Melanie Avalon: Yeah, I've seen it. Very, very cool. Awesome. Well, these have been absolutely wonderful. So definitely keep the questions coming, especially with the holidays coming up. We'll have to have a discussion, Cynthia about maybe next week, we can just have a nonlinear Q&A discussion about how to do the holidays with your fasting window, because I know that's a big challenge or obstacle that a lot of people perceive so we can discuss that a little bit next week. So, the show notes for today's episode will be at ifpodcast.com/episode291. And like I mentioned, those show notes will have a full transcript, so definitely check that out. And you can get all the stuff that we like at ifpodcast.com/stuffwelike and I definitely need to update that page. And you can submit your own questions by directly emailing questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. And you can follow us on Instagram. We are @ifpodcast, I am @melanieavalon, Cynthia is @cynthia_thurlow_ and I think that is all the things, and this is going to date us and we talked about this already. But are you doing anything this weekend for Halloween?

Cynthia Thurlow: My best friend from college is coming in town. I haven't seen her in four years because of the pandemic, she lives in Atlanta. So, she's flying in on Friday, flies out on Sunday and my teenagers are planning on going to parties this weekend. So, my husband and I, we've had this complete shift in our personal lives where now our kids' social lives run our weekends, one is driving, one is not because my youngest goes to a high school that's pretty far from our house. It means his friend group is all over the suburbs and so we spend a lot of time on Friday and Saturday nights carpooling them everywhere. So, they are not doing anything officially until Monday, but I believe there is one Halloween party on Saturday night for my oldest and that's a whole minefield of topics that we've had to have discussions over. For anyone that's a listener that has teenagers or young adults, ooh, you think it's hard when they're babies and toddlers, it's a whole another level of conversations when they are teenagers, especially if they're driving and, crossing your fingers that the 16 years prior to this that we have embedded in them good decision-making properties in their brains, which are not fully developed. 

Melanie Avalon: So, this is a good moment for me to have something I discussed yesterday. I interviewed, do you know A.J. Jacobs, Cynthia?

Cynthia Thurlow: I do not.

Melanie Avalon: Oh, my goodness, listeners please listen to this interview when I air it. It is out of my entire show the most fun I've ever had on an interview in my entire life. He is a four times New York Times best seller. He just does random crazy stuff that he gets curious about. So, his newest book is called The Puzzler and it's all about puzzles, all the different types of puzzles, and just he went and did all this crazy stuff, and how they affect our life and what we can learn from them. And he has a book on where he tried to live biblically for a year, follow the Bible, literally-- what it literally says to do, it's so funny. And his most well-known book is called The Know-It-All, I think. And he read the entire encyclopedia [laughs]. I am like shared what he learned. But he was such a joy. And I was cracking up laughing. And it was a fascinating conversation. I just really thoroughly enjoyed it. The reason I'm talking about this, so sorry, is one of his books is called, it's about gratitude thanks-- something, I'll put in the show notes, where he decided to thank every single person involved in making his daily cup of coffee. Every person. Like the person who made the beans, the person who made the cup, the person-- and he went and found all them and told them thank you. 

So, it's a book about gratitude and one of the things he talked about was the importance of being specific in gratitude. So, when you're thinking about what you're grateful for or telling somebody what you're grateful for, you can amplify the gratitude potential if you're really specific. So, I'm going to take this moment for specificity gratitude, to say, I am so thankful to my mom for driving me back and forth to play practices growing up, because we lived a little bit far away from the school and she would pick me up take me home, I would do some more work, then she would take me back to play practice. Wait, then she would leave, then she would come back and pick me afterwards. "Oh, my goodness." That is so much driving. Thank you, mom [laughs]. So, thanks to all the moms out there. Thanks for driving your sons and daughters.

Cynthia Thurlow: Yes, it's one of those jobs we don't look for those thank yous, but when we get acknowledgment, it's just an amazing feeling.

Melanie Avalon: Yes, so, well thank you. So, this has been absolutely wonderful. And I will talk to you next week.

Cynthia Thurlow: Sounds good.

Melanie Avalon: Bye.

Thank you much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team. Administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Nov 06

Episode 290: Creatine, Vitamin E, Safe Tanning, Slow Weight Loss, Cheating On Your Diet, Toothpaste, Digestive Enzymes, Leaky Gut, And More!

Intermittent Fasting

Welcome to Episode 290 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

LMNT: For A Limited Time Go To drinklmnt.com/ifpodcast To Get A FREE Sample Pack With Any Purchase! Learn All About Electrolytes In Episode 237 - Our Interview With Robb Wolf!

BEAUTYCOUNTER: Keep Your Fast Clean Inside And Out With Safe Skincare! Shop With Us At melanieavalon.com/beautycounter or beautycounter.com/cynthiathurlow And Use The Code CLEANFORALL20 For 20% Off PLUS Something Magical Might Happen After Your First Order! Find Your Perfect Beautycounter Products With Melanie's Quiz: Melanieavalon.Com/Beautycounterquiz
Join Melanie's Facebook Group Clean Beauty And Safe Skincare With Melanie Avalon To Discuss And Learn About All The Things Clean Beauty, Beautycounter And Safe Skincare!

Introducing... Creatine by Cynthia Thurlow

Ep. 234 Metabolic Longevity and Vitamin E with Dr. Barrie Tan

NUTRISENSE: Get $30 Off A CGM At Nutrisense.Io/Ifpodcast With The Code IFPODCAST

Listener Q&A: Charles - Safe Tanning Bed

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Listener Q&A: Rachel - Weight loss too slow

Listener Q&A: Darcy - Diet Cheating

Listener Q&A: Deborah - What about Toothpaste?

Primal Life Organics

Ep. 153 – Fix Your Mouth/Fix Your Health: Reversing Tooth Decay Naturally with Trina Felber

Listener Q&A: Ann - Digestive Enzymes

AVALONX MAGNESIUM 8: Use The Code Melanieavalon For 10% On Any Order At Avalonx.Us And MDlogichealth.Com!

Listener Q&A: Alyssa - IF and digestive changes

Gut Assist - Leaky Gut Repair Supplement Powder

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 290 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: A 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Hi, friends, I'm about to tell you how you can get my favorite electrolytes for free. Yes, completely free. And the feedback we have received about LMNT electrolytes from our audience is overwhelming. You guys love LMNT and I'm so excited because our new offer allows new and returning customers to get free LMNT. On top of that, they're super popular. Grapefruit flavor is back. If you've been having issues with intermittent fasting, electrolytes may just be the thing that you need and/or have you heard of something called the keto flu? Here's the thing. The keto flu is not actually a condition. Keto flu just refers to a bundle of symptoms, headaches, fatigue, muscle cramps, and insomnia that people experience in the early stages of keto dieting. Here's what's going on. When you eat a low-carb diet, your insulin levels drop. Low insulin in turn lowers the production of the hormone aldosterone. Now, aldosterone is made in the kidneys and it helps you retain sodium. So, low aldosterone on a keto diet makes you lose sodium at a rapid rate. Even if you are consciously consuming electrolytes, you might not be getting enough. In particular, you need electrolytes, especially sodium and potassium in order for nerve impulses to properly fire. Electrolytes can easily be depleted while intermittent fasting.

Robb Wolf, who as you guys know is my hero in the holistic health world, worked with the guys at Ketogains to get the exact formulation for electrolyte supplements to formulate LMNT Recharge, so you can maintain ketosis and feel your best. LMNT Recharge has no sugar, no coloring, no artificial ingredients, no junk. They're used by three Navy SEALs teams, they are the official hydration partner to Team USA weightlifting, they're used by multiple NFL teams, and so much more. We have an incredible offer just for our listeners. You can get a free LMNT sample pack that includes all eight flavors. Citrus, watermelon, orange, raspberry, mango chili, lemon, habanero, chocolate, and raw unflavored, and the raw unflavored by the way is clean fast friendly. You can try them all completely free when you make a purchase at our link, drinklmnt.com/ifpodcast. You can get this offer as a first time and as a returning LMNT customer. I know there are a lot of returning LMNT customers. The feedback I hear from you guys, "loving LMNT" is amazing. LMNT offers no questions asked about refunds on all orders. You won't even have to send it back. And this offer is exclusively available only through VIP LMNT partners. You won't find this offer publicly anywhere else. So, again, the link is drinklmnt.com/ifpodcast. And we'll put all this information in the show notes.

And one more thing before we jump in, are you fasting clean inside and out? When it comes to weight loss, we focus a lot on what and when we eat. It makes sense because these foods affect our hormones and how our bodies store and burn fat. But do you know what is possibly one of the most influential factors in weight gain? It's not your food and it's not fasting, it's actually our skincare and makeup. As it turns out, Europe has banned over a thousand compounds found in conventional skincare and makeup in the US due to their toxicity. These include endocrine disrupters, which mess with your hormones, carcinogens linked to cancer, and Obesogens, which literally can cause your body to store and gain weight. Basically, when we're using conventional skincare and makeup, we are giving these obesogenic compounds direct access to our bloodstream.

And then in our bodies, studies have shown they do things like reduce our satiety hormones, increase our hunger hormones, make fat cells more likely to store fat, and more resistant to burning fat, and so much more. If you have stubborn fat, friends, your skincare and makeup may be playing a role in that. Beyond weight gain and weight loss, these compounds have very detrimental effects on our health and they affect the health of our future generations. That's because ladies when we have babies, a huge percentage of those toxic compounds go through the placenta into the newborn. It is so, so shocking and the effects last for years.

Conventional lipstick, for example, often tests high in lead and the half-life of lead is up to 30 years. That means when you put on some conventional lipstick, 30 years later maybe half of that lead has left your bones. On top of that, there is essentially no regulation of these products on the shelves. That's why it's up to us to choose brands that are changing this. The brand that is working the hardest to do this is Beautycounter. They were founded on a mission to change this. Every single ingredient is extensively tested to be safe for your skin, so you can truly feel good about what you put on. And friends, these products really, really work. They are incredible. They have counter time for anti-aging, counter match for normal skin, counter control for acne and oily prone, and counter start for sensitive. I use their Overnight Resurfacing Peel and vitamin C serum every single night of my life and their makeup is amazing. Check out my Instagram to see what it looks like. Tina Fey even wore all Beautycounter makeup when she hosted The Golden Globes. So, yes, it is high-definition camera ready. They have so many other products, deodorant, shampoo, and conditioner that I love, products for babies, and so much more. You can shop with us at beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code CLEANFORALL20 to get 20% off your first order. Also, make sure to get on my clean beauty email list. That's at melanieavalon.com/cleanbeauty. I give away a lot of free things on that list. So, definitely check it out. You can join me in my Facebook group, Clean Beauty and Safe Skincare with Melanie Avalon. People share their experiences, ask questions, give product reviews, and I do a giveaway every single week in that group as well. 

And lastly, if you're thinking of making clean beauty and safe skincare a part of your future like we have, we definitely recommend becoming a Band of Beauty member. It's sort of like Amazon Prime for clean beauty. You get 10% back in product credit, free shipping on qualifying orders, and a welcome gift that is worth way more than the price of the yearlong membership. It is totally completely worth it. So, again to shop with us go to beautycounter.com/melanieavalon or beautycounter.com/cynthiathurlow and use the coupon code, CLEANFORALL20 to get 20% off your first order. And we'll put all this information in the show notes. All right, now, back to the show.

Hi everybody and welcome, this is episode number 290 of The Intermittent Fasting Podcast. I'm Melanie Avalon and I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, Melanie, how are you?

Melanie Avalon: I'm good, I started the last podcast off with a question. But I have another question for you for this podcast. How is your creatine going?

Cynthia Thurlow: Good, we're officially told that it will be out before Thanksgiving. I keep getting these vague ideas and we'll make sure we link up the waitlist for creatine so that we can ensure people that are most interested in receiving it. But yes, things are moving forward in a quick direction. I'm hopeful that everything will be out by mid-November. That's what I'm assured will happen. So, it's very exciting.

Melanie Avalon: Why did you choose creatine as your first supplement?

Cynthia Thurlow: I think because-- what's really been a struggle for me as a middle-aged woman is not only the muscle piece, it's so much harder to maintain and build muscle in perimenopause and menopause. And the more research I dove into and the more I talk to colleagues of mine like Dr. Gabrielle Lyon, the more I realized I was like, "This is a huge issue for women." So, last year, I started taking creatine, and in my Stories this past week, I actually put objectively how I've been able to increase the weight week to week, and my trainers like thrilled and so from my perspective, I think for a lot of women, one of the things we have to work very diligently and actively on is not just muscle health, but also brain health. And those are the two key areas with regard to creatine that for me I think are really compelling. And I think my second-- I really believe, I just did a great podcast with Dr. Barrie Tan, talking about the value of a certain type of vitamin E, it's tocotrienols.

And so, the supplementation with that is actually really beneficial for bone health, like significant improvement in bone health. And so, I think my first couple of products are going to really be geared towards helping women find supplements that can be beneficial at different stages of our lives, but also make them accessible. I'm going to take all the research and really understand it, so that I can then provide information and say, "Hey, listen, I myself have no interest in ever being diagnosed with osteoporosis, but I'm doing all the things along with supplementation with these tocotrienols, which is a form of vitamin E and taking creatine to help maintain muscle and bone health, which we know is really, really, important and honest to God, I never thought about it. So, I was probably 45." And I want younger people to think about it before that time period and I want people that are older than me to have options that aren't surrounding the latest potion, pill, or powder which you and I both know is proliferative in the health and wellness space.

Melanie Avalon: I cannot agree anymore and that's interesting about the creatine. It's something that honestly, I think I just disregarded for a very long time because I eat such a high-protein diet that all of the amino acid-related things I've been like a-- well, I probably get getting enough. But I've been hearing more and more it pop up on so many conversations on different podcasts like Dr. Gabrielle Lyon, like you mentioned talking about a lot when Layne Norton was on either Rogan or Peter Attia, he talked about it at length, and I keep seeing it pop up other places, too. And I'm like, "Oh, I think this is something I should be supplementing with." And the timing of it is just working really well in that I'll just start with yours because I know it'll be the best on the market. So, very excited for that.

Cynthia Thurlow: I appreciate all of your support, for everyone that knows Melanie and I are each other's biggest cheerleaders and it's totally genuine, and I love seeing what you've been able to build in your business and how many people you've been able to help with your supplement line.

Melanie Avalon: I'm just excited that yeah, together we can make a change because like you mentioned it's such a sketchy world, the supplement industry. And I already knew that before making my own, which is the reason I wanted to make my own. But now actually being in the process, it's like my eyes are being opened and I've just learned so much. So yeah, listeners definitely vet the supplements that you're taking. Actually, speaking to the vitamin E, because I know that I think there are like eight forms of vitamin E, how do people know which form to get?

Cynthia Thurlow: Yeah, so it's the derivative are tocotrienols and so what's interesting is these are derived from a plant in South America. I mean, Dr. Tan's whole explanation just blew my mind. He was there in South America to do something else and he stumbled upon this plant called annatto. And so, annatto is the derivation of this particular tocotrienols. And there is so much research being done on this derivative. It helps in metabolic health, there are anti-cancer benefits, there are bone health benefits. So, from my perspective sometimes podcast guests end up on our podcast schedule, and maybe at the time you're not fully familiarized with who they are, or their research, or their areas of expertise. And as I was prepping, I was like, "Oh, my gosh, this is actually really, really, interesting." And how do we make it accessible to everyone so that people can walk away from a podcast and be able to take action? Dr. Tan actually has, I don't know when his podcast-- It should be out in November, but he actually has a book on his website that's totally free. So, people can read the research and read his information. He's just passionate about being able to help people. And he's using gold-standard research. It's not epidemiologic research, it's double placebo blinded trials. And it's interesting that something I thought I would have no interest in has now become something I'm incredibly interested in. So, his podcast will be out in November, I forget which date?

Oh, no, his podcast just came out. What am I saying? It was last weekend. I'm getting all my dates mixed up, Melanie. So, that podcast dropped last weekend and we've gotten so much good feedback. And even though someone else who had interviewed him said, "Oh, we know his accent's kind of heavy-- he's got a wonderful sense of humor." He's so passionate, he's like a derivative of Rick Johnson. Like, he's that passionate, he's so like, warm and you can't help but love him. And so, I got off and thought to myself, I have to bring in back to talk about another topic because we didn't really touch on cancer research. But the long explanation of this is that I do think that there's a lot of value, I started taking annatto a few months ago, and I haven't repeated my DEXA but I'll be interested to see what that looks like. Because I've been staunchly opposed to using biphosphates, which for anyone that's listening a lot the bone-building drugs actually technically they build more bone, but it's not strong bone. And so, what got people concerned about them is that dentists were seeing a lot of mandibular necroses, so bone in the jaw being really like spongy and so there's no drug that's without side effects. So, to find something that has the potentiality of really improving the quality of bone because people may not know this, but teenagers as they're growing, they have this acceleration of bone-building potentiality in their bone for so many years because they're growing. And what happens in menopause is that the opposite happens, you've got more bone destruction than you do bone building.

And this is why women in menopause really are at great risk for weakened bones falling and breaking bones progressing to osteoporosis, which is what we want to avoid. If you're a thin Caucasian woman, you're probably already at risk for osteopenia. But you can't compare my bone strength at 51 to someone who's 20. It's like not a good comparison. And so, I remind people all the time that you can do all the right things, but some of us need a little bit more support. And that's another reason why I think testosterone therapy is not something to fear. If you get to a point where that helps you maintain bone mass that's another-- we actually have testosterone receptors on our bones as well as estradiol and progesterone and I think a lot of people forget that it's that loss of hormones that really start to accelerate bone turnover in a negative way in menopause.

Melanie Avalon: Yeah, I'm so happy you're drawing attention to this because I think it's something people just don't think about. People will seem to think that bone is like static or fixed, not that it's like this living tissue that all the process that you mentioned and how much that can be affected by diet and lifestyle. So, now I'm just voting, I vote that you make vitamin E as your second supplement that annatto, what annatto?

Cynthia Thurlow: Annatto, umm hmm.

Melanie Avalon: Annatto I got to find a good one.

Hi, friends. I'm about to tell you how you can get $30 off one of the most incredible ways to track your blood sugar levels. See how your fasting is affecting you, see how your food choices are affecting you, and truly take charge of your health, that would be the NutriSense CGM program. If you've been listening to this show, you know that we are a little bit obsessed with continuous glucose monitors also known as CGMs. If you know how your body is actually responding to different foods, amounts of sleep, stress, fasting, exercise, wine, anything else you're doing in your life, then you can truly achieve your health goals. Whether that's managing your weight, eating foods that make you feel good, having energy throughout the day, optimizing the longevity, understanding your blood glucose is important. And for example, you might even realize that your diet doesn't need to be super restrictive, it just needs to be the right diet for you that is sustainable.

Here's the problem. True, you can check your blood at the doctor or you can randomly check it with a glucometer at home where you prick your finger. The problem is that's just a snapshot. It's a single picture of that brief moment in time. If I've learned one thing from wearing continuous glucose monitors is that your blood sugar can change a lot even from minute to minute. You really need to get a sense of how your blood sugar is changing all throughout the day. 

When you wear a continuous glucose monitor, which is painless to put on, I promise, I have a lot of videos on my Instagram of how to put them on. So, definitely check those out. It gives you a picture of your blood glucose levels 24/7 for 14 days. What I love about the NutriSense CGM program is it has a super awesome app that helps you interpret the data and really understand what's going on. In the app, not only does it track your data, but you can log meals, see macronutrient breakdowns, and so much more. It even gives you an overall score for each of your meals based on your body's response, so you can really find what meals are working for you. Each subscription plan includes one month of free support from a registered dietitian.

NutriSense dieticians will actually help you identify what you should be paying attention to, what that data actually means, they can really hold your hand if you're new to the space or if you're already knowledgeable, then they can provide you even more advanced tips and recommendations. They'll make sure that you adjust your diet and lifestyle to find what you enjoy doing so that you can have long-term sustainable changes. They will even act as accountability partner on your journey. NutriSense also has a private Facebook group for members, where you can find support from other members and learn about their experience. I love wearing a CGM. I just think it is so profound. Even if you just do it once for 14 days, I think you will learn so, so much. But then, of course, lasting sustainable change can take time. Getting a longer-term subscription, it can be an amazing option to consider. 

NutriSense has 6 and 12-month subscriptions and those are cheaper per month allowing you to not only achieve your health goals but also ensure that you stick to your new healthy lifestyle for the long term. It's helped me realize for example how low carb versus low fat affect my blood sugar levels, how berberine has an amazing effect at lowering my blood sugar, and so much more. You can get $30 off any subscription to a NutriSense CGM program. Just go to nutrisense.io/ifpodcast and use the coupon code, IFPODCAST for $30 off. That's N-U-T-R-I-S-E-N-S-E dot I-O slash IFPODCAST with the coupon code, IFPODCAST for $30 off any subscription to a CGM program. There's a reason Cynthia and I talk about CGMs all the time. We love them. NutriSense is giving you guys access to them. So, definitely check this out. And we'll put all this information in the show notes. All right, now, back to the show.

Melanie Avalon: Okay, shall we jump into some questions for today?

Cynthia Thurlow: This is a question from Charles. Subject is "Safe tanning bed." "Have you come across a safe tanning bed for home use? I believe what I'm looking for might be called a hybrid tanning bed. I live in Chicago and there are several months where I can't get good sun exposure. I'm not interested in tanning, just exposure to light spectrums that could mimic what could be attained from the sun. I believe there are beds that can provide UVA, UVB, and even some red light therapy."

Melanie Avalon: All right, Charles, thank you for your question. Thank you for your controversial question. I feel like people get intense about this question. So, I looked up the hybrid tanning bed thing and what I found-- it looks like it's a bed that combines normal tanning rays, like potentially just UVB but maybe UVA as well, with the red light therapy. So, that's all I could find on that specifically. So, my thoughts on this are at-home tanning beds, all I can speak to is what you would look for in a tanning bed and if you are using it therapeutically for the benefit of vitamin D production. And the reason I wanted to answer the question around now is because this airs on November 7, so getting colder, less sunlight and I believe vitamin D levels are so important to our overall immunity and our health in general. People think vitamin D is a vitamin, but it's actually a hormone. The book I'm reading right now, actually, I'm prepping to interview a woman, Dr. Heather Moday, she wrote a book called The Immunotype Breakthrough: Balance Your Immune System, Optimise Health and Build Lifelong Resistance, I am loving it, it's really deep dive into the immune system.

I'm learning so much but I was actually reading the section last night about vitamin D, she makes the argument that it is the most important nutrient when it comes to the immune system. Actually, every single cell of the immune system has a vitamin D receptor, so it's so so important. And then the stats on vitamin D levels and health are really shocking. And I think they really came into play, especially with COVID because then they started doing more studies on COVID mortality or COVID outcome rates and vitamin D levels and there was a really strong correlation there with lower vitamin D levels being problematic for that. So, the point of that is that I think getting vitamin D from the sun or UV rays likely can have some benefits extending a little bit beyond a vitamin D supplement, which is also an option as well. And you can also get vitamin D from some foods, but not in huge amounts.

So, what I actually do and again, this is controversial and I'm not recommending this as a blanket statement, and I don't take skin cancer lightly, but UVB is the ray that actually stimulates the production of vitamin D in your body. UVA is the ray that actually gives you that tan effect. So, it works well because tanning beds tend to be more expensive when they're more UVA because people want to get it for the tan, but it's actually the UVB that you want. And so, you'll often find that cheaper beds are UVB beds. So, what I often do or have done in the past, although I just got my InsideTracker results back and my vitamin D level is too high. I think I've been supplementing too much, but I will get a membership. And at Palm Beach tan, they actually have a pretty good setup where you can get credits, and I just use it in the UVB bed. And I would literally in the winter go in for literally two or three minutes in the UVB only bed. So, that's a personal choice. I cover my face. Yes, that's a personal choice.

So, I can't really speak to at-home tanning beds I assume if you get a UVB tanning bed at home and try that. The red light though is-- it would have completely different therapeutic benefits. And of course, for red light therapy, we absolutely adore Joovv. I do use red light therapy every single day of my life. It's one of my favorite things. And it's really great for skin health, also for reducing inflammation, red light and near-infrared can help with muscle recovery. I use it for circadian regulation. So, waking up in the morning and going to bed at night. So, if you go to joovv.com/ifpodcast and use the coupon code, IFPODCAST you will get a limited-time discount that's J-O-O-V-V dotcom and I think they're going to have some pretty amazing deals for Black Friday. So, if you've been thinking about getting one now might be the time or upcoming might be at the time. So yes, I'm very curious, Cynthia, what are your thoughts on tanning beds?

Cynthia Thurlow: Well, I'm not a fan of tanning beds. But for people that are looking for light exposure, especially people that are more prone to seasonal affective disorder, I like Lux Box, so it's L-U-X and you can get them on even Amazon and a certain amount of exposure in the morning can be hugely helpful. And for anyone that's north of Atlanta, which is mostly United States, you don't get enough sun exposure. It's not just the Midwest, areas of the country where it's really cold in the winters. So, I generally recommend that they get a Lux Box, and then just getting sunlight exposure in the morning can be hugely helpful. The way to think about UVA and UVB light is to understand that UVA light is aging, it will age your skin, then UVB light can burn you. So just to kind of differentiate that those are the two, like the UV lights and what I'm more familiar with. Melanie's absolutely the expert on red light therapies much more so than I am. I actually really like my PMF mat, but that's a completely separate tangential rabbit hole that I'm going to avoid. So, I would say Lux Box is what's going to be most helpful if you're feeling like you need some seasonal-- if you're prone to like depression and just otherwise not feeling good during wintertime because you're not getting a lot of sunlight exposure, a Lux Box is not going to give you multiple spectrums of light but it can definitely help if you feel like that light exposure piece is impacting your mood. And it wasn't clear from Charles' question if that was of issue, but I just wanted to-- this was like a general recommendation I do with a lot of my patients in winter.

Melanie Avalon: Yeah, I think that's great. I actually use a-- it's not Lux Box brand. Mine is called Day-Light, I got it on Amazon, I can put a link too in the show notes, it's on right now. So, I use that and my red light every day. And I love it. Just as a side note, I think it's really important to get-- I don't know how often you should do this but going to a dermatologist and just having them check your entire body for any potentially cancerous growths on your skin can be really helpful. My mom actually recently went through that, and they did find one and they had to like take out a whole chunk of skin. And not to say it's fine, but it can be fine if they find it early. That's why getting those checks can be really important. It's really intense though how much skin they have to take off just to like, even if you have just a tiny little freckle with cancerous potential.

Cynthia Thurlow: They have to get clear margins. Yeah, they thought I had a squamous cell on my forehead this summer. And so, they took like a punch biopsy, it turned out to be fine. But you definitely want to be getting your skin shocks every year. And to do with them well, you have to be pretty undressed. So, if they're doing it and you're just sitting on an exam table and you're not in a paper gown without your bra and your underwear on, then they're doing you a disservice quite honestly.

Melanie Avalon: Now I'm inspired, I need to go get one. This is inspiring [chuckles] this is action. This podcast is having effects on my life.

Cynthia Thurlow: Yes. Take action people.

Melanie Avalon: Yes. I'll do it. If you guys do too. Okay, shall we go on to our next question?

Cynthia Thurlow: Yes.

Melanie Avalon: So, this question comes from Rachel, the subject is "Weight loss too slow." And Rachel says "Hello, IF community. I've been clean fasting now for about six months and although I have lost some weight and inches, I feel very defeated and that the weight I'm looking to shed is just not coming off fast enough. Sort of looking for ideas on how to get the process moving quicker. Here is normally what I do each week, 20 to a 22-hour fast each day with no more than a 3 to 4-hour eating window sometimes 2. I try and do a meatless Monday with about a 42-hour fast a couple of times a month. My fast is completely clean with just water and black coffee. I try and limit my carb intake although I am not completely rigid. I do feel great with fasting and I know you need to eat what feels good to you but maybe I'm not making great choices. I'm normally a pretty healthy eater, lots of veggies, not a lot of meat, but just sort of feeling stuck. I'd a few medical things this past year and I wonder if my body is busy healing rather than shedding weight. Thanks for reading and hope to hear back. Love all the books and the podcasts, by the way, best, Rachel.

Cynthia Thurlow: Well, Rachel, thank you for your question and I mean there is a lot of different variables here when I see that you've been clean fasting and you're frustrated with weight loss resistance. I really start with the basics, what is your sleep like? How are you managing stress? Are you consuming an anti-inflammatory diet? I know you mentioned you're trying to limit your carb intake and I do encourage women if they're weight loss resistant to actually track their macros like to know what you're really eating and chronometer is a free app. They really do a nice job, but I would track total carbs not net, net is a cheat that's a byproduct of the processed food industry. In order to deflect attention to what we really need to be tracking. I would make sure you're eating enough protein, especially if you've got a very narrow feeding window that's another concern, your body may think you're not eating enough food. That's why I think those OMAD situations can be problematic. You can further slow your metabolism, especially if you're not seeing some degree of weight loss or changes in body composition. I think a great deal about are you lifting weights. What's your gut health like? And obviously testing is helpful for that, what toxins are you exposed to, and then you mentioned that you're doing a clean fast, you're limiting your carbs, you're not eating a lot of meat, it doesn't per se have to be made. It could be poultry, it could be fish, it could be eggs, all can be helpful. And then you mentioned you've had some medical things going on, and I don't know what they are. So, it's hard to say if there's a degree of inflammation going on in the body, if you're healing from surgery or healing from an illness, I also don't know from your question how old you are. So, if you're 35 or 40, things can get a little more complicated as you get older, it doesn't mean that it's impossible. So, there are definitely things to think about. I don't like any women to get really rigid and do the same thing every single day.

So, varying your fast is important, making sure you're sleeping, making sure you're managing your stress, getting enough protein in, tracking your carbohydrates, alcohol is a sneaky thing and for some people they don't even register that our bodies will process. Alcohol is a toxin, so if you eat a big meal, and you have a couple of glasses of wine, your body is going to prioritize processing the alcohol before processing the rest of the food which can get stored as fat. So, a lot of things to think about-- certainly you can write us back and give us a little bit more information. But that's kind of my first pass at your question is that there are other things that are going on, we get healthy to lose weight, so we haven't yet determined what's going on. And, if you're really struggling that much, I would encourage you to see your primary care provider, get some lab work done, find out what's going on with your thyroid, find out where you are in your cycle, that can also impact success.

I think that would really be helpful. looking at fasting insulin, I talk about this a lot. Maybe get a glucometer or CGM to determine how good is your blood sugar control. You may think that you're doing really well with your food choices but then you find out that you've got a sustained high blood sugar all day long, and your body perceives that you're under a significant stress and duress. And so, looking and getting a little bit granular about some of those things, I think would be very helpful.

Melanie Avalon: I thought that was very comprehensive. Yeah, so I'm just thinking if she's doing a one-meal-a-day situation with no more than a 3 to 4-hour eating window sometimes 2 like she says, and she's purposely not eating a lot of meat and having a lot of veggies. So that's a lot of volumes. It's hard for me to see how she's getting a lot of protein in that window. And protein is the most satiating nutrient, it's the nutrient that provides the most, building structure for the body, and also from a metabolic standpoint, it stimulates the metabolism that actually requires energy to break down. So, sort of exciting when people are at this place where they have the potential to increase the protein because I think they can potentially see a huge difference if they focus on that specifically, especially when it comes to shedding the weight. So, either adding in protein or switching out some of what you're eating for protein-rich sources, instead, I think might have a huge effect on that. I've also found that-- and I don't want to make a judgment either way. But sometimes people kind of indicate that maybe they know that there could be better food choices that might work better, but I think they just need somebody to tell them that.

And it's hard to know if that's the situation, but it's language like, "I know you need to eat what feels good to you but maybe I'm not making great choices or I'm normally a pretty healthy eater." And so it might be that you are making great choices, and you are a pretty healthy eater, or it could be that maybe there are some things in there that aren't serving you as much as they could be. So that's more like a psychology of it. There's a lot of potential there for making changes in what you're actually eating in addition to all of the lifestyle things that Cynthia pointed out.

Cynthia Thurlow: Absolutely.

Melanie Avalon: Alrighty, shall we go on to the next question?

Cynthia Thurlow: Yes, this question is from Darcy. Hi, "I cheated on my diet while I was supposed to be fasting. Can I just do a 48-hour fast to help get back on track?" Thank you.

Melanie Avalon: So, I love this question because I think it's one of the shortest questions we've answered on the podcast that actually speaks to something that is a huge topic. And it's the idea-- Well, first of all, can you do a 48-hour fast to help you get back on track? Yes, you can do anything and the reason I'm pointing that out is people write us all the time. I think I talked about this recently on another question on another episode, but it's like people think they need permission to do things in their life from-- I don't know from us, from society. You don't need permission from anybody to do anything. I just want to put that out there. So, yes, you can, the question would be, would that be a good thing to do? I think like that's the framing I would put on it. So, I have very mixed feelings about all of this. In general, I think there's a huge benefit to having an intermittent fasting pattern that works for you. And if you have a one-off situation where you "Cheated". Well, first of all, I think we should reframe it and not even see it as cheating, because I mean what is cheating? What does that even mean? You just chose to eat something that wasn't in line with maybe what makes you feel best instead, like it's not really cheating in my opinion. I think semantics are really important. And how we frame these things if you have a moment where you ate things that don't agree with you, or that are inflammatory, or that you feel the need to atone for which goes back to that cheating language. So, you can fast longer and that will very likely help with reducing inflammation, getting you back into the fat-burning state, it can have a very positive beneficial beautiful effect. I encourage people to fast longer if they think it will make them feel better. The sticky thing is I don't want people doing that out of fear and out of a feeling that they have to fast to undo what they did. Because it can very quickly become a disordered eating mindset, it can very quickly become over restrictive. So, in the ideal world people would follow the diet that works best for them. And maybe they have moments where for whatever reason, they're going to eat foods that are going to have side effects that are going to have-- are going to make them not feel so good on the flipside, and that's okay, too. And how you deal with that is okay. You can just keep on with your normal fasting window. If fasting longer physically makes you feel better. I mean I think that's fine. I just think people can get into a pattern like a binge-fast cycle where they're either binging or having these foods that make them feel bad and then responding with an atoning long fast. I think it can quickly spiral into a mindset that can feel like you're in a trap, like we want fasting to be freedom for people, we want it to be a good thing, we want it to bring benefits to people's lives and enhance their life and make them feel better. We don't want fear and insecurity and feeling like it's something they have to do to make up for their choices. So, yeah, I could go on and on about it. But Cynthia, what are your thoughts? 

Cynthia Thurlow: I think our external dialogue is reflective of our internal dialogue. And when you say you cheated on the diet, it's very pejorative, you're judging yourself and in fact, what you should say is today I didn't eat as ideally as I would like to and tomorrow is a new day. So, reframing that whole judgment of yourself is really important. We have to give ourselves grace. None of us are perfect. I have days when my macros are a mess. I always reframe it as like, okay, tomorrow's a new day, I'm not going to-- I'm not going perseverate or overthink it, I'm just going to make tomorrow a better day, I'm going to make better choices tomorrow. Now, when we blow the motherlode, if you will, on a meal or a whole day of not eating ideally, the things that I think are important to lean into is adequate sleep, lots of hydration, eating lots of green things. And by that, I mean salad and if you tolerate non-starchy vegetables, hitting your protein macros, getting some exercise, and if it's appropriate for you, you can do a longer fast, you shouldn't punish yourself.

I think a lot of people it's a self-flagellation behavior where we feel like, we really have to treat ourselves unkindly. And human nature's we are not going to be perfect, life is perfectly imperfect. And so, Darcy, I'd really encourage you to reframe those thoughts and to be kind to yourself and obviously you don't need our permission to do a longer fast, but there are lots of different ways to get yourself back on track when you've not eaten as ideally as you would like to. And first and foremost is that mindset piece. So, the judgmental way that you're describing what you did, I would encourage you to say today wasn't the best day and that's okay and tomorrow I'm going to get back on track and that's really the way to reframe it and move forward.

Melanie Avalon: Yes, we are on the same page. It's tricky because I just think that mindset is so so key, the way you described and the way I was describing it and I also want people to have agency and the freedom to fast if they want. And I think you can do both like you can fast to help yourself feel better from whatever happened. But it can just so quickly become judging yourself and restrictive and atoning and that's not what I think it should be about. Shall we go on to our next question?

Cynthia Thurlow: Absolutely.

Melanie Avalon: So, Deborah wants to know, "What about toothpaste?" Deborah says, "I in my window in the early evening but sometimes forget to brush right away, later I get ready for bed and need to brush. I use baking soda a lot, but once in a while Dr. Bronner's Peppermint paste, not lately because it's a flavoring. Is baking soda, okay? And okay. I'm excited about this conversation because, Cynthia, have we talked about toothpaste, you and I on the show?

Cynthia Thurlow: I think we have?

Melanie Avalon: We have?

Cynthia Thurlow: I do feel like we have.

Melanie Avalon: Well, I feel, because I know Gin and I have talked about a lot. I couldn't remember what you've said you brush your teeth with?

Cynthia Thurlow: Yeah, I use Primal Life Organics and I actually right now have the unflavored variety because my kids-- we were trying to get them onboard and they didn't love the powder as opposed to a paste. And so, I ended up taking it and using it. in regards to Deborah's question, unless you are swallowing your toothpaste, I don't want anyone listening to feel like they have to stress about brushing their teeth because we all need to do that and baking soda is fine. I think as long as you're not swallowing it like toddlers, when we have toddlers and we have to remind them to spit it out and not swallow it. I think you're completely okay. If you're using a cleaner product like Primal Life Organics as an example, we'll link up the affiliate code for that. They're completely clean products, there's no junk, there's no artificial anything, artificial sugars, etc., no fluoride, and we'll link up the podcast I did with Trina Felber, she's another advanced practice nurse who has kind of created this whole clean-mouth line, which I'm obsessed with and I think it's really fantastic. But with regard to Deborah's question, brush your teeth, spit out the toothpaste, and don't stress about it. That's my feeling, I think this is one of those things that should be no stress. It's like if you have to brush your teeth in your fasting window, no big deal. I do it all the time, totally fine. What do you think?

Melanie Avalon: I feel the same way. And it's interesting. I think toothpaste is one of the places where I can really see an evolution in my-- so, I use the word neurosis, it was one of the first things that I went through a period where I was like, "Oh, I have to make own. Order kaolin clay and mix it up myself." And I went from that to, I really don't stress about it as much anymore. I found a few that I really like. I was doing the tooth powders for a long time. I found them a little bit messy for me and I finally went back to tubed toothpaste and I actually use a few different ones. But if you want a tubed toothpaste, it doesn't have really any sweet flavor to it. Well, it is salt toothpaste. I love that toothpaste. It is so strong and it has no sweet flavor which is really hard to find. But I agree with Cynthia that-- I also love Primal Life Organics. So, that's a great plug. And we will put links in the show notes to that. But yes, I agree with Cynthia, don't stress about it, and baking soda is completely fine.

Cynthia Thurlow: Exactly.

Melanie Avalon: All right., shall we go on to our next question?

Cynthia Thurlow: Yes, this question is from Ann and the subject is, "Digestive enzymes." "I love listening to your podcast while I'm doing chores around the house. I only have 30 episodes left. I love this. I have a question about taking digestive enzymes. I had my gallbladder removed about 13 years ago. Ever since that I've dealt with stomach cramps and having to go to the bathroom after eating a heavy meal especially if it was the first meal of the day. Before my surgery, I had no stomach issues. I could literally eat anything anywhere anytime with no worries. I come to think that the stomach issues were just a normal side effect of the surgery and I just had to deal with them. However, I started talking to friends and family who have had their gallbladder removed and realized they did not deal with this problem like I do. I heard you mentioned digestive enzymes on the podcast and I did some research and decided to give them a try. I've been taking them for about a month and they've helped so much. I go to the bathroom like a normal person now and don't have to worry about stomach issues after eating."

Here's my question, "I've been doing intermittent fasting for a year. I do mostly OMAD with no restrictions. I've lost about 30 pounds. It has been slow, but I feel great and not restricted at all. I've never been able to stay on a diet this long and have even been on several vacations and I've been able to get back on track easily. About the time I started taking the enzymes my weight plateaued and I felt like I even gained a couple of pounds. My weight loss has yo-yoed up and down the whole time but not like this. I'm just wondering if the enzymes are helping me absorb fats that previously my body could not and that has something to do with the plateaus. I haven't changed my eating habits at all, I definitely don't want to stop taking the enzymes because of how much they have helped me, and I'm sure this is healthier for my body but I'm just curious, I would like to lose about 50 more pounds. Thank you so much for all the great information you provide" Ann.

Melanie Avalon: All right Ann, thank you for your question. I think this is a great question. I've thought about it more in regards to-- so I eat a lot of fruit as listeners know, like pounds of fruit every night and I've gone through different levels of taking digestive enzymes with it. At one point, I was taking barely any and then other times I've been taking a lot. I've noticed that when I take a lot and I take a fruit-- I get like no digestive issues from it. But it really breaks down the fruit like not to be TMI, but I can see the difference in my bowel movements from how it's affecting the fruit. And so, I've been concerned about the sugar release from that. I'm like am I actually turning the fruit into more like fruit juice in me because I'm breaking down the fiber with the digestive enzymes? I don't want to scare people away from digestive enzymes but I just wanted to speak how I have thought about the nuance of this. And to clarify, I tend to go really extreme.

So, I would take tons of digestive enzymes, I wouldn't be concerned about this if it was just like a very small or actually probably even normal dosing. And that said, I have also thought about this more in relation to Ann's question, probably historically, not so much with enzymes. But with people-- especially when I was really having a lot of GI issues and gut health, I would spend hours and hours and hours in Facebook groups about SIBO and IBS and things like this. And people would share stories about having leaky gut and having issues with their gut health, and then gaining weight from healing their gut. And presumably that's from absorbing more food, like absorbing more nutrients. So, I can completely see if you went from a state where you weren't really absorbing your food and then you're taking these enzymes, and now you are absorbing your food. Yeah, I could see how that would make your weight plateau and/or even gain depending on what you're eating which kind of comes back to what I feel like I always come back to on this show, which is-- the enzymes are working for you, that's great. I would keep using them, this is awesome. And you seem to be on that page.

If weight gain is a concern and even if it's not, I would mitigate that or address that with the actual food choices, which she doesn't mention. She just says that she hasn't changed her eating habits, but she hasn't mentioned what those are. So, that's what I would look to, "Oh, I got it, I do mostly one meal a day with no restrictions. Okay." So, it sounds like you're eating just-- if there are no restrictions, I'm guessing it could even be like standard American diet. If that's the case, there is so much potential here for A, both having wonderful and improved digestion with these enzymes and B, not plateauing and not gaining, maybe even losing weight by making some conscious decisions around the food that you are putting in your body. So, if there are no restrictions right now, I mean, you could just start it very basic, which would be shifting from just not having processed foods, so you don't have to worry about macros or even the types of foods but shifting to a whole foods-based diet. That could have a huge, huge impact on your-- not only your weight but your health in general. And then a lot of people in our audience already exist within that whole foods-type paradigm. And then that's when I think you can move to the next step of like a macro-based approach of like low carb or low fat for example. Yes, especially if you have 50 pounds to lose. Yeah, I would definitely look at the food choices, I would keep the enzymes, look at the food choices. What are your thoughts, Cynthia?

Cynthia Thurlow: That was a really comprehensive answer. It's interesting, in my patients that have had their gallbladders out, I typically have found tremendous success with ox bile or bile salts, that's usually a starting point for them versus digestive enzymes and a lot of that has to do is when your gallbladder is removed, you still produce bile, but it just drips all day long. So, most of my cholecystectomy patients, which is the fancy word for gallbladder removal-- most of them really struggle with either constipation or diarrhea. And if Ann is finding that she's feeling better on digestive enzymes, I would stick with what she's doing because she feels better. Yes, and I don't know Ann's age but we start absorbing less nutrients as we get older. That's why we actually need more protein as middle-aged people, so Ann could be young, but I'm guessing she's probably at least middle aged just based on the fact the way she's describing things. The other thing I think about is OMAD and weight plateaus. I started thinking about the fact that your body might have just gotten to a point where with just only one meal a day you're not getting enough macros in, you may need to change things up. I always say when you hit a plateau, it's time to change things up either tracking your macros to see very clearly how much protein you're eating a day. Are you overeating fats? Are you eating too many carbs? How's your sleep? How's your stress management? Are you lifting weights? As people start losing weight, sometimes they want to get more physically active. Do you take walks? Where are you in your menstrual cycle? Or are you no longer menstruating? Those kinds of things are very helpful. But I would say shaking things up is going to be very important. And then, giving consideration, most of my patients with a cholecystectomy really benefit from ox bile or bile salts. These are supplements you can get over the counter. And those have been hugely impactful.

Melanie Avalon: Oh, by the way, have you ever taken, Cynthia, ox bile or anything like that?

Cynthia Thurlow: I have, I tend to be-- I think probably the listeners know that in 2018, I got the worst food poisoning in my life in Morocco, picked up a parasite and then ended up six months later having a 13-day hospitalization. So, my gut has really been ravaged over the last several years. And I've been told by my providers that I've had episodes of fat malabsorption, so have I ever taken it? Yes. What we've kind of worked on is artichoke, artichoke extract is actually a little more gentle than traditional digestive enzymes. And the more I've learned, the more I understand that there's so much bio-individuality, you may be able to take a really strong digestive enzyme, which for me would just not work. And so, there's a little bit of give and take, but yes, I have tried ox bile and bile salts, I do and have had episodically. I'm not someone that tolerates like a lot of animal fat. So, lean meat I do much better with and I think my gut microbiome really took a massive hit in 2018 into 2019. So, I'm definitely very carefully navigating what I add in to support digestion. How about you? Have you tried it?

Melanie Avalon: I went through a period where I was using it like you, I favor lean meat, so I didn't really see the need for it specifically not being on as high of a high-fat diet. I'm glad you brought up the individuality with digestive enzymes. This is a very vague teaser, but I think after we get out the next few supplements that we have, I have a really big supplement idea, project that I want to do that's going to relate to bio-individuality with digestive enzymes, I think it's probably going to be my big supplement project of 2023. So, people get excited. So yeah, but it's so true because especially with the digestive enzymes because goodness knows I have tried so many different ones and it really is about finding the one that works for you and that suits your personal digestion.

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Melanie Avalon: Related to digestion. We have a question from Alyssa. She says, "IF and digestive changes." And Alyssa says, "I am new to IF, about three weeks in doing a 17-7 window and I have never had any sensitivities to food. I have found since starting IF my stomach has become sensitive, as soon as I open my eating window and start eating, I find myself nauseous and bloated. I have experimented with many different types of foods, tried eliminating different food groups to see what is triggering this, and always have the same outcome. I've also had increased problems with loose bowel movements since starting IF. I'm wondering if my body is just taking longer to get used to this new eating pattern and if this is a common finding among new IFers. I definitely want to make this a lifestyle as I've researched and researched and I found nothing but good information. But the stomach issues are such a turn off. I think I've lost a little weight, but at this point, I really just want to get a handle on the way I feel and focus on weight loss as a secondary concern. I have about 25 pounds to lose but I did lose 40 before discovering IF, but hit a plateau for several months. I'm 29.5 not willing to claim 30 just yet female and have two kids, ages 1 and 2, if that information means anything to you." So, continuing the digestive issue conversation. Thoughts?

Cynthia Thurlow: Alyssa? Well, I think that there's obviously something going on, I would start with lighter foods, try some bone broth to break a fast, I would have a light salad, I would gauge to see if it's certain types of foods that are exacerbating your loose stools. I actually had a really good podcast with Megan Ramos and we kind of talked about troubleshooting some of these issues. And I just find that breaking the fast with a lighter meal or backing off on fasting entirely, you're talking about a 17-7, maybe especially as a 29-year-old female, you shouldn't be fasting right before your menstrual cycle. I would really try to give yourself a solid week in your follicular phase, which is after your bleed week and see how you feel, trying a little more protein, not doing as much uncooked vegetables, light, light, light stuff and see how you feel.

Melanie Avalon: Yeah, something that I'm focusing in on is the fact that she said she'd never had sensitivities to food and now she does. And I think so-- this actually could be very helpful, it could be a flashlight situation. It's possible that you were having inflammatory reactions to food, but you just weren't realizing it until IF kind of like paved the way for you to have that moment where you actually saw how your body was reacting to food, which I think a lot of people do experience that, which is a good thing. I think. So, I love Cynthia's suggestion, definitely check out that episode with Megan Ramos. I'd be curious-- you said you've tried many different types of foods and you've tried eliminating different food groups. I'd be curious the extent to which you have tried A, elimination protocol as like an actual protocol because I've interviewed a lot of people who talk about elimination diets to solve these issues and a consistent theme with all of them. I'm thinking of like Dr. Will Cole, I'm thinking of Dr. Peter Kozlowski, I'm sure quite a few others.

A consistent theme is like really doing it properly, like actually committing to this short-term elimination diet rather than just kind of like, casually, like eliminating one thing here, because there-- Well A, the effects of food could probably last up to three days as far as just like, for some people the transit time and just the effects from that food. So, if it's a casual approach to eliminate things, you might not be able to see a difference if you just eliminate one thing one night and see how you react and there are so many factors involved. I think taking a conscious approach to an elimination diet might be helpful, but is possible that your body is still adjusting because it has been about three weeks. I would love to hear if things have changed. But yes, yes, yes, yes. I do think a lot of people do experience this. And there's a lot of potential to find the answer. And so, something that might be a game changer. This is something that I'm definitely, definitely, definitely going to make my own version up in the future because it's something that when I go through issues, especially with feeling like my stomach is sensitive and reacting to foods, like right when eating, there are different blends that involve L-glutamine and when taken on an empty stomach it can really help rapidly heal the gut. Particularly L-glutamine, as well as DGL which is, I don't even know how you say it, deglycyrrhizinated licorice extract. So, the one I take right now and I have got to make a version of this, it is shocking how much it helps me. I would love to hear Alyssa if you take this if this really, really, helps you. So, it's called Gut Assist. It's by Dr. Danielle, you can get on Amazon, I'll put a link to it in the show notes. Like right now it has 6337 reviews and 4.5 stars. So, it is a combination of L-glutamine of something called arabinogalactan, and then that DGL as well as some aloe vera. I would definitely, definitely try that. And then also stay tuned because I'm definitely going to make my own in the future. So, if you want to get updates about that, you can go to avalonx.us/emaillist. And you can also text AvalonX to 877-861-8318. That will get you text updates as well as a 20% off coupon code. So definitely check that out. Okay. Any other thoughts from you, Cynthia?

Cynthia Thurlow: No, I think you did a great job.

Melanie Avalon: You as well. Well, this has been absolutely wonderful. So, a few things for listeners before we go. If you would like to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. The show notes for today's episode will be at ifpodcast.com/episode290. Those show notes will have a full transcript, so definitely check that out. And you can follow us on Instagram, we are @ifpodcast, I am @melanieavalon, Cynthia is @cynthia_thurlow_ and I think that is all things. Anything from you before we go?

Cynthia Thurlow: No, this has been fantastic as always.

Melanie Avalon: I agree and keep the good questions coming and we will talk to everybody next week.

Thank you so much for listening to The Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice, and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team, administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

[Transcript provided by SpeechDocs Podcast Transcription]

STUFF WE LIKE

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Cynthia: cynthiathurlow.com

Theme Music Composed By Leland Cox: LelandCox.com

If you enjoyed this episode, please consider leaving us a review in iTunes - it helps more than you know! 

 

 

Oct 23

Episode 288: Fiber, Psyllium Husk, Glyphosate, Constipation, Nutrient Timing, Hunger During The Fast, Protein, Bioidentical HRT, And More!

Intermittent Fasting

Welcome to Episode 288 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Cynthia Thurlow, author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

BUTCHERBOX: Grass-Fed Beef, Organic Chicken, Heritage Pork, Wild-Caught Seafood: Nutrient-Rich, Raised Sustainably The Way Nature Intended, And Shipped Straight To Your Door! For A Limited Time Go To butcherbox.com/ifpodcast And get one 10-
14 lb Turkey FREE in your first box! 

AVALONX Magnesium 8: Get Melanie’s Broad Spectrum Complex Featuring 8 Forms Of Magnesium, To Support Stress, Muscle Recovery, Cardiovascular Health, GI Motility, Blood Sugar Control, Mood, Sleep, And More! Tested For Purity & Potency. No Toxic Fillers. Glass Bottle.  Get on the email list to stay up to date with all the special offers and news about Melanie's new supplements at Avalonx.Us/emaillist, and use the code melanieavalon for 10% on any order at Avalonx.Us and MDlogichealth.com!

To submit your own questions, email questions@IFpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For A Limited Time Go To butcherbox.com/ifpodcast And Get One 10-14 Lb Turkey FREE In Your First Box!

How She Grew Pre-Sale! 

The Melanie Avalon Biohacking Podcast Episode #165 - Dr. Karen Becker

Go To yummerspets.com And Get 10% Off Sitewide With Code MELANIEAVALON!

Listener Q&A: Becca - Benefiber and psyllium husk pills

Simply Fiber: Digestion Resistant Starch/Fiber Blend

FOOD SENSE GUIDEGet Melanie's App To Tackle Your Food Sensitivities! Food Sense Includes A Searchable Catalogue Of 300+ Foods, Revealing Their Gluten, FODMAP, Lectin, Histamine, Amine, Glutamate, Oxalate, Salicylate, Sulfite, And Thiol Status. Food Sense Also Includes Compound Overviews, Reactions To Look For, Lists Of Foods High And Low In Them, The Ability To Create Your Own Personal Lists, And More!

Listener Q&A: Samantha - Nutrient Timing?

#224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D.

Use Code CYNTHIA30 for $30 off or MEL for $50 off at lumen.me!

Listener Q&A: Moose - Struggling with IF

Ep. 206 Pt 1: A Deep Dive into Perimenopause- Hormonal Imbalances and Birth Control with Dr. Tabatha Barber

Ep. 212 Pt. 2: A Deep Dive into Hormonal Imbalances and Menopause with Dr. Tabatha Barber

AVALONX MAGNESIUM 8: Use The Code Melanieavalon For 10% On Any Order At Avalonx.Us And MDlogichealth.Com!

Listener Q&A: Robin - Two Questions

The Melanie Avalon Biohacking Podcast Episode #123 - Dr. David Minkoff

Get a discount at melanieavalon.com/perfectamino with the code melanieavalon

Ep. 198 – Dispelling Myths About Hormone Replacement Therapy

Our content does not constitute an attempt to practice medicine, and does not establish a doctor-patient relationship. Please consult a qualified health care provider for medical advice and answers to personal health questions.

TRANSCRIPT

Melanie Avalon: Welcome to Episode 288 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker and author of What When Wine: Lose Weight and Feel Great with Paleo-Style Meals, Intermittent Fasting, and Wine. And I'm here with my cohost, Cynthia Thurlow, Nurse Practitioner and author of Intermittent Fasting Transformation: The 45-Day Program for Women to Lose Stubborn Weight, Improve Hormonal Health, and Slow Aging. For more on us, check out ifpodcast.com, melanieavalon.com, and cynthiathurlow.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment and no doctor-patient relationship is formed. So, pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time and get ready for The Intermittent Fasting Podcast.

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Hi everybody and welcome, this is episode number 288 of The Intermittent Fasting Podcast. I'm Melanie Avalon, I'm here with Cynthia Thurlow.

Cynthia Thurlow: Hey, Melanie, how are you today?

Melanie Avalon: I'm good, how about you?

Cynthia Thurlow: Doing well, just in the throes of homecoming and trying to narrow down options for my grumpy 14-year-old child who is intermittently grumpy but today it's mostly grumpy.

Melanie Avalon: Homecoming like homecoming dance?

Cynthia Thurlow: Yeah, so they have a homecoming event. My kids go to two different high schools and my older son’s already had homecoming, and so this is my younger son's first opportunity to go and today I finally got him to tell me what he wants to wear. And it's an interesting compilation, it's interesting to see between different high schools what kids are wearing and I have my work cut out for me.

Melanie Avalon: Just having flashbacks now. I'm just thinking about how funny growing up there is the key moments where you get to dress up and wear dresses. And now in my life, any chance I can get, I like to dress up for things with dresses.

Cynthia Thurlow: I love it. I'm actually in the midst of finalizing my outfit for this black-tie event for an event I'm going to in Scottsdale. And my poor husband was watching just like box, after box, after box, coming to our home because we live in a--

Melanie Avalon: Did you order from Macy's?

Cynthia Thurlow: I did not, I did not. It was from a variety of places. There is a wonderful woman I work with who's a stylist and I love her to pieces and she knows me really well. And so, we were trying to find a heel that wasn't six-inch stilettos because I was trying to explain it. I was like, I cannot stand in five-inch heels all night long, my feet will hate me. And I finally found the right dress, and I found the right bag, and I found the right shoe, and I found the right earring. And so now I feel I'm finally I can exhale and I have my outfit for next week. Because I don't get an opportunity to get that dressed up all that often but I will be on stage a couple of times, so, I'm excited.

Melanie Avalon: Yes, that's the crème de la crème, the black-tie events. I have one coming up in November and, "Oh, it's so exciting." I'm like all about it.

Cynthia Thurlow: I know you are you wearing black?

Melanie Avalon: Oh, yes. Always.

Cynthia Thurlow: I love it. I'm wearing like a-- it's an off shoulder, it's maroon, it's fitted, which is generally what I look better in any way. And then these really beautiful shoes and beautiful handbag. And because you have to have something to throw your lipstick and your phone into, now we're getting very nuanced, but I love getting dressed up. And it's a full day, I have a documentary I'm participating in, and then I have that in the evening. And I have to give an award out. I will be on stage and have to be 100% and I was laughing and saying I think I'm going to need a nap because I'll be on Pacific Coast time. And my body's going to think it's a lot later than it is?

Melanie Avalon: How tall are you again?

Cynthia Thurlow: 5'3.5”.

Melanie Avalon: Oh, we've talked about this. You look a lot taller.

Cynthia Thurlow: Everyone tells me that. It's one of the most common things people are like you're short, and I was like, with heels on I look very tall. But I usually, I've started now wearing heels on stage. And then my feet have absolutely decided they're done with heels, I almost always bring some fashion sneakers that I have that are awesome, they're very neutral, and then people are like, "Oh my God, you're so petite." I'm like, “Yes, I am.”

Melanie Avalon: That's how we're similar to. People say the same thing about me. They think I am a lot taller.

Cynthia Thurlow: How tall are you?

Melanie Avalon: 5'4.5”.

Cynthia Thurlow: Oh, yeah, so you're not much taller than me?

Melanie Avalon: Yeah, I actually love my height. I would to be like really tall. I don't know I think it could be fun. I like when your average female height, which I think literally 5'4.5 is average female height. I can still wear you're mentioning-- I love wearing really tall heels. I can still wear the really tall ones and then be a really good height.

Cynthia Thurlow: Yeah, well and it's funny. Lewis Howes last week was humored because I came in, in my fashion sneakers, and he complimented me on those. And then I was like, "Oh, hang on a second," I had the shoe in the bag and he was laughing. He's like, every woman does this. And I was like, “Oh, why are you going to kill your feet?” And I put them on for the interview and photos and stuff. And then before I left, I quickly changed my shoes again and he just thought that was hilarious. And I said men don't understand a lot of these really beautiful shoes. And I love a beautiful shoe, are not shoes you can walk in the city and be comfortable. And I'm all about-- I'm just at a stage in my life where comfort is important, fashion is important, but there is a point to which I'm like, I'm not going to go down an elevator, walk across a bunch of concrete, try to flag down a car, and have to do that in four-and-a-half-inch heels. I'm gotten very practical.

Melanie Avalon: Also, the thing that related to that, that men don't understand, the getting ready process. It's so funny. I went-- Oh, it was fabulous. I went to this event at the Georgia Aquarium. It was called Aqua Vino so it was wine tastings and dueling pianos and an auction. So, I was supposed to go with my dad. But this happened right after all of the hurricane stuff that I talked about last week. And he was just really stressed and wasn't feeling up to it. And thanks, dad, you let me know like right before. I was like, who can I find to go with me? And I was like, well, it has to be a guy because no girl would be able to get ready at this last minute. So I went with my cousin, it was really fun. Although I got so many DMs about my date, I was like, "It's not a date."

Cynthia Thurlow: Nope, Melanie. This is my cousin. That's on Wednesday night.

Melanie Avalon: A decade younger than me.

Cynthia Thurlow: Yeah, my cousin and I went out with him and I was laughing because he's super tall. And, he has a wonderful girlfriend who wasn't able to make the dinner. And we ended up going to this French bistro place and it was fantastic. We both had an amazing steak and I was saying to him I was I forget how tall you are, you are a foot taller than me. I look like a midget standing next to you.

Melanie Avalon: Good times. Some women do not like dressing up, which I will never understand.

Cynthia Thurlow: No, I'm a total girly girl. I mean, I'm all about the details.

Melanie Avalon: I live for it.

Cynthia Thurlow: I'm all about the details and it totally makes a difference.

Melanie Avalon: Especially traveling, it's so stressful for me and I don't like doing it. But if there is any chance of getting me there be like well, there is a formal or black-tie thing. I'll be like, okay, maybe. So, yes. Well, okay, two quick announcements before we jump in. I mentioned both of these last weeks. There is an amazing online conference summit thing called How She Grew. It's by a few influencers, including Noelle Tarr, who is the co-host of the Well-Fed Women Podcast and one of my really, really, good friends. And I am a speaker in it. Cynthia might be, we're not sure. But it is all about-- really, it's all interviews with successful women and how they grew. So how they're doing what they're doing with their businesses, very practical, helpful information to just like learn how these women did and do what they're doing. You can go to melanieavalon.com/howshegrew, if Cynthia is doing it, you can go to cynthiathurlow.com/howshegrew. This episode airs October 24th, up until November 1st, they will have a pre-sale discount. So, use that link now to snag that discount.

And then, the second thing I want to talk about, I talked about this last week as well but as of this recording right now, the episode that is airing on Melanie Avalon Biohacking Podcast is with Dr. Karen Becker for her book called The Forever Dog. Definitely, friends, even if you don't have pets, listen to it. But if you do have pets, listen to this episode. This is actually fun fact. My editor who edits the show, he never comments, I just send him the episode he sends it back edited. He never ever makes a comment about the content for this episode. He literally wrote out like, wow, this was one of the most amazing things I've ever listened to. And so many people have told me that. It's mind-blowing if you care? If you are concerned with the health of your pets, listen to it. All of that to say I think what we feed our pets is really, really important. And I'm thrilled because there is a new company called Yummers. And I think I'm really good friends with the co-founder Rebecca. She actually co-founded it with Antoni Porowski from Queer Eye for the Straight Guy and his boyfriend, Kevin. But they actually make really incredible healthy toppers for dogs and cats. Literally no problematic additives, just the good stuff, they have like, liver supplement toppers, chicken toppers.

One of the problems with conventional pet food is that they include all of these natural flavors and enhancers to make the pets really want to eat it. And that pet food really ends up commercial pet food. I mean, it's shocking. It's basically the equivalent. This is what Dr. Karen Becker was talking about. It's the equivalent of eating breakfast cereal for like every single meal of your life. So, like an entirely processed diet, fake, low moisture, not the correct macronutrients to support health it's really, really, a problem. And they use these natural flavors to make the pets basically addicted to it. Yummers uses real food ingredients that have that same palatability effect for the dogs and cats so they love it and it's super healthy. My mom's puppy, Mia, loves it, my sister's cat Jackie loves it. So, definitely check it out. I'm excited to see the future of the company because they might have more products in the future but they have a lot right now as well. So, you can go to yummerspets.com. That's Y-U-M-M-E-R-S-P-E-T-S dot com. And you can use the coupon code, MELANIEAVALON, to get a discount site wide.

Cynthia Thurlow: There are many things I love about the fall. The crisp cool weather, the warm, cozy fall flavors, all of the festive holidays coming up. One thing I don't love though is the constantly growing to-do list that seems to come with the fall season. Shuttling my kids to various activities combined with all of the prep work for holidays can feel like another full-time job on top of my actual job. I know I'm not alone in this. That's why the Prep Dish is the best way for busy people to get healthy meals on the table without stress. Subscribers receive an email every week with an organized grocery list and instructions for prepping meals ahead of time. This means dinnertime is super quick and easy every day. And if you think you don't have time to meal prep, I used to think the same thing. But with the Prep Dish super-fast meal plans I can prep five healthy dinners in just one hour. Trust me that one hour of meal prep pretty much saves my sanity for the rest of the week. It is 100% worth it. If you want to serve meals like these without the stress, the founder Allison is offering listeners a free two-week trial to try it out. You can't beat that. Check out prepdish.com/ifpodcast for this amazing deal. Again, that's prepdish.com/ifpodcast. So, your first two weeks free, this is a total no-brainer. Recent favorites were the slow cooker Moroccan spice chicken with roasted sweet potatoes and kale as well as the bison burgers with caramelized shallots and sauteed asparagus. Again, you can check out prepdish.com/ifpodcast for an amazing deal, giving you a two-week trial to try this out.

Melanie Avalon: Let's jump into questions. Would you like to read the first question?

Cynthia Thurlow: Sure, this is from Becca. Subject is: "Benefiber and psyllium husk pills." “Before I started intermittent fasting, I was taking Benefiber and psyllium husk pills in the morning and before bed, I have continued to do that since I started fasting. I was wondering if I'm breaking the fast with these two things. I have not really been successful at losing any weight. I've been doing intermittent fasting since January. I feel good and my clothes fit better. But it is occurred to me that I may be breaking my fast without realizing it by taking these two things. Any suggestions? Maybe I don't even need the fiber or I should be taking something else instead. Thank you for your help. Becca.”

Melanie Avalon: All right, Becca, I'm really excited about this question because it's something I've been wanting to talk about. Because it's becoming a thing. I know Dave Asprey talks about it in his fasting book. I know Dr. Gundry talks about it, I think in his most recent book, a lot of people have been-- I know she's asking about it breaking the fast but a lot of people I guess, Dave Asprey and Gundry, and maybe some others have talked about the benefits of taking fiber while fasting to not feed you but feed your gut microbiome, which then can create short chain fatty acids from that. That idea does not resonate with me so much. And the reason being is even if fiber is non-nutritive to us, like I said, just now the gut microbiome can break it down and create energy from it. And just on top of that, it's a substance that stimulates the digestive process. even if it doesn't have "calories" to us, it still has to go through that digestive process and stimulate that. I think personally, taking in something that is doing that while fasting, I find it counterintuitive to the concept of fasting. I'm not a fan of fiber during the fast. On top of that, I don't know why you're taking the fiber. You don't say why? I'm wondering if it's just because there is this conventional idea that we need to be taking fiber. I am all about getting fiber from whole foods, I would look at your food choices. And how can you eat fiber-rich fruits and vegetables that really work for you and your digestive system? So those are my thoughts "Oh, she said she's not been successful and losing any weight." I mean, that could be a lot of factors. I don't know that it's the fiber completely, I would look at your food choices in general and the fasting window that you're doing. But those are my thoughts on that. What are your thoughts, Cynthia?

Cynthia Thurlow: Well, I think on a lot of levels, typically Benefiber and psyllium are recommended by traditional allopathic trained providers. For a lot of people, it's to help with constipation, just to include the amount of fiber in their diet, I do agree with you and echo your sentiments about getting fiber from whole food sources. My concerns about Benefiber and psyllium husk is the exposure to glyphosate. For listeners that's a pesticide, herbicide that is most of our crops are exposed to. We know that there is a direct link with developing small intestinal hyperpermeability, which is when we develop leaky gut, foods that you're eating or then you're leaking food particles into the bloodstream, which can set up an inflammatory response and you can become sensitive to the foods that you're eating. From a health provider's perspective that's the first thing I think about, there are definitely other options. I prefer that fiber be taken if you do have to consume it during your feeding window. I do the idea of resistance starch, I actually have a product called Simply Fiber, which has green banana flour in it and potato starch, which are in their clean sources. But I always recommend that people consume those in their feeding window as opposed to in their fasted state.

And I agree with Melanie, that there can be many, many contributing factors to why you're not seeing weight loss. It could be as simple as your macros, meaning insufficient protein, too many of the wrong types of carbs, and inflammatory fats like seed oil, really closely examining what you're eating in your feeding window, and making sure you're getting a sufficient amount of protein in, I say no less than 100 grams a day. I do talk a lot about these types of subjects in my book. I also think about what else are you doing? How's your sleep? What's your stress management style like? Are you lifting weights? What's your gut health like.” There can be many things that can contribute to weight loss resistance or an inability to see weight loss in and of itself. I think there is a lot that could be going on, I would experiment with the types of products you're using. I would try to bump up your non-starchy vegetables to see if that's able to help you in the absence of using Benefiber and psyllium husk and then really getting acquainted with other options that are available to you if you feel you do need those to have a bowel movement, and there are people that benefit from taking supplementation with fiber, but you want to look at the quality of what you're consuming, to make sure it's the least inflammatory choice of all options.

Melanie Avalon: I am so glad you brought up the glyphosate issue. I do think that is such a huge problem. I really think that's a problem, too. I was mentioning earlier how dog food and pet food is eating cereal all day. That's something I think it's probably a lot of huge issue for glyphosate exposure.

Cynthia Thurlow: And it's interesting not to step on your toes while you're speaking. But there was a podcast I did with Jeffrey Smith last fall that to me really opened up my eyes. He's doing a lot of research and a lot of advocacy to help educate people about exposure to glyphosate and genetically modified foods. And we'll include that in the show notes so that that's available for you to learn from. He's a researcher and also an advocate and pretty powerful message. And someone that does it in a way that makes the information accessible and not scary. But certainly, it's a resource that I recommend for people to learn more about so that they're limiting their exposure overall to glyphosate as much as possible.

Melanie Avalon: I'm glad you said that, I really need to bump him up. He's the one that fell through the cracks with us trying to schedule him for the show.

Cynthia Thurlow: And that happens. I mean I think we all realize that happens, especially when you've got a show your Biohacking Podcast where you just get inundated. We do too. I would say, more often than not, we end up turning potential people away because there just isn't- there aren’t enough slots in here to get all the podcasts people in. But yeah, he would be fantastic on your podcast.

Melanie Avalon: Yeah, I really, really want to interview him. I think what happened was he reached out at the height of a lot of the politicalness of COVID. And I wasn't quite sure the extent of his content, and I wasn't sure if it was going to be too controversial for the show. But now after hearing you interview him, really looking at his work now I really want to bring him on. And it's not because I personally, I like to think I'm very open minded. it's not about me, it's more about concerns with podcast, censorship that can happen.

Cynthia Thurlow: Yeah, and we stayed way away from the fray of discussions about the pandemic, and the virus and all those things to stay. He didn't even bring any of that up. I completely understand.

Melanie Avalon: Yes, I'm happy you brought that up. And then I'm so happy you brought up the constipation piece. Because yes, that is a reason that a lot of people take this often. And I wish that I was the type of person that responded well to fiber helping constipation because there are a lot of people who fiber does help constipation. There are also a lot of people who, and I existed for a very long time-- this is a reason that I want to talk about this. I existed in a very long-time experiencing constipation and thinking fiber was the answer and like trying to shove the fiber down my throat. And it just made it much worse. And it took me a long time to really realize that. I just want to encourage people that if they're taking fiber for constipation, and it's not working, they might benefit A, from just not taking extra fiber, B looking at the type of fiber they're taking, so like for me, I do really well with a low-FODMAP diet. So, I eat fiber-rich vegetables that are low in FODMAPs, which are easily fermentable different substrates that can exacerbate gut issues due to fermentation.

That's why people see my stories all the time buying pounds of cucumbers from Costco, like, I do really well with a lot of fiber from cucumbers and blueberries and things like that, so just Becca, if it is constipation related, the fiber may or may not even be helping, I will put out a resource. If you're curious about FODMAPs, you can get my app called Food Sense Guide. It has over 300 foods for 11 potentially problematic compounds that are found in foods so things you may be reacting to based on your personal constitution. It does include FODMAPs. It also includes lectins and gluten and histamine and oxalates and sulfites and all these things. you can get that at melanieavalon.com/foodsenseguide and Cynthia do you have thoughts about Dave Asprey, Gundry, and people who say that you actually should take fiber while fasting to create these short-chain fatty acids?

Cynthia Thurlow: I think there are many different ways to impact short-chain fatty acids and I'm embarrassed to say I know far more about this subject than I'd like to. Just because of my own gut health journey post-- goodness, so many different things including LPS, lipopolysaccharides. I probably had some E. coli, I got a parasite when in Morocco, I've been treated for said parasite and there has been a lot of gut rebuilding, and I think it's going to be a long process. I actually do better when I take-there is actually a product called [unintelligible 00:25:06] and I do better taking that in a fed state. My stomach's just--

Melanie Avalon: What is it?

Cynthia Thurlow: [unintelligible 00:25:11]. I'll have to give you some separate information. It's essentially a fertilizer for the short-chain fatty acids. And my functional medicine practice really likes it. And so, from their perspective, that's a superior option. I think for a lot of people, some of these resistant starches can be very bloating, and you had mentioned, some people are more sensitive to some of these FODMAP-esque properties, some of these carbohydrates. I think on a lot of levels, obviously, Dr. Gundry is an incredible resource. Dave Asprey obviously does his research as well, he's very comprehensive, but I really think it comes down to the beauty of the N of 1, what really works best for you. And the products I take, I take in my feeding window because I then don't get bloating, I then don't have some of those side effects. There is a degree of experimentation that I think can be helpful. I think for some people they're told to take these products on an empty stomach to lessen the likelihood that they are going to have slowed absorption or less likely to interact with other foods or other supplements or medications and I get that, but I think it's all about the individual. And I know we talk a lot about that. But I think each one of us have to do a little bit of experimentation to find out what works best.

Melanie Avalon: Awesome. I love that, same page, alright. Shall we go on to our next question?

Cynthia Thurlow: Absolutely.

Melanie Avalon: This question comes from Samantha. The subject is: Nutrient Timing? And Samantha says, "Hey, ladies, thank you as always for all you do, seriously changing the world for the better." You cover so many great topics, but I'd like to ask more about exercise. I really embrace exercising while fasted which feels great. I usually do light lifestyle exercise, a brisk walk with the dog, house and yard work, sports with my kids. I know I should start doing more lifting and weight-bearing exercise as I'm approaching 40, it's on the list. In past episodes, you’ve spoken about refueling not being an urgent postexercise need. What you do in the 24-hour period is what matters. Also, I love the discussion surrounding the need for protein. I have made protein a focus for me and my family. Recently, I've noticed the phrase nutrient timing. I've heard Cynthia refer to it and today, Dave Asprey. Can you elaborate and discuss, are there certain levels of exercise where the timing does matter more for certain macros pre and post workout? Also, on a side note, my son plays hockey and hates to eat prior. He's only 10 and a strong lean kid. I encourage at least a protein smoothie. Sometimes he accepts and sometimes he refuses, but he has a ferocious appetite for the rest of the day, so I'm not overly concerned. He eats super healthy too and definitely does not lack for energy. But might he benefit from some better nutrient timing? Thanks, sincerely, Samantha in Canada, she also says she is excited for her Lumen delivery this week.

Cynthia Thurlow: Great question, Samantha, thank you for your questions. And I'm glad that you are leaning into the possibility of starting some weight-bearing exercise, strength training is so so important for us. And for anyone that's listening, the more muscle mass we have, the more insulin-sensitive we are. And this becomes even more important as we are getting closer to middle age, in terms of protein and refueling and nutrient timing, obviously with a teenager and I'm assuming your son is, oh he is 10, so he's a preteen, so he's a tween, kids are still growing. And I think it's certainly very important to make sure that they are getting the right types of fuel in around workouts, they're still growing. Hopefully, we are not still growing at this stage of life we're in, protein and carbohydrates around workouts for them. I think for each one of us, and I'll go back to the bio-individuality piece, I think it's very, very important to identify what makes our bodies feel good. Obviously, if you're lifting heavy things, and you're doing intense physical activity, it's going to be more important to how you are timing those food intakes. And if you're intermittent fasting, I get less concerned about people feeling the need to refuel around a workout. Because as we've talked about before, it's more important over a 24-hour period of time, what I get concerned about though is that a lot of women undereat protein, and if you're trying to build muscle, you're trying to lean into metabolic flexibility.

And remember peak bone and muscle mass is our 20s and 30s. if you're 40 you're already at that stage where you're losing some degree of muscle mass and I know on days I lift heavy yesterday was a leg day and it was a punishing leg day, because I had not been lifting heavy the entire week because I was traveling, I did break my fast earlier and I ate more food than I normally do not because I overate, but intrinsically, my body was telling me I needed to have a larger serving of protein, I needed a bit more carbohydrate. And when I talk about nutrient timing, I also like to think about intuitive eating. And not everyone that's listening is at a point where they're able to intuitively eat. I don't want to spend a lot of time focusing on that. But I do want to encourage people to understand that if you are eating to build muscle and you are intermittent fasting, you have to be very careful about when you're eating. And this goes along with not doing these long fasts, not just eating one meal a day, it's very important that you're getting two good-sized portions of protein in in your feeding window, along with the right types of carbohydrates, and healthy fats if they're not already incorporated into your protein source. It sounds like you're doing a lot of the right things. But kids are very different, even my teenagers are still growing. I'm more concerned about them getting their fuel in around their workouts because they are still growing up, so they're still in this massive anabolic phase. I'm on the other end of the spectrum trying to make sure I'm not breaking down my muscle by not giving it enough stimulus and then not giving it the right nutrients over a 24-hour period of time. Melanie, what are your thoughts?

Melanie Avalon: I thought that was great. This was perfect timing because I'd already scheduled this question in the lineup. And then I had been listening to Peter Attia’s, I think his most recent episode, have you listened to it with Don Layman?

Cynthia Thurlow: So good.

Melanie Avalon: Yes. it's episode number 224. The title is Dietary protein: amount needed, ideal timing, quality, and more by Don Layman, PhD. I was excited last night because he started talking answering this question. I was like, yes, it’s perfect. So, interestingly and apparently, he works with Dr. Gabrielle Lyon a lot, which is awesome. He talks about the nutrient timing of protein. And I realize--, okay, she specifically makes it about protein, which in general, nutrient timing, I do believe is speaking to this protein question. Something I did not know until listening to that episode last night. Yes, so protein is key to maintaining muscle, building muscle post workout. He talks about how if you don't achieve a certain amount of protein after the stimulus of working out, you're not going to build muscle, you've got to have at least was it 30 or 50 grams, I'd have to double check. People who just graze on protein in small amounts all day, they made the case that even if you ate the same amount of total protein, if you ate it in small amounts constantly, you wouldn't get those benefits, especially if you're older because there is a slight caveat for children.

Cynthia Thurlow: Your protein needs change as you get older, you actually need more protein, because you may not be capable of breaking it down as efficiently, so I totally agree with you.

Melanie Avalon: Yeah, exactly. That's why I mean, even in the longevity sphere of people who are really steeped in the vegan world, who are proponents of low-protein diets, even they say, after a certain age, I think it's 60, how you do need a higher protein intake. And what it likely comes down to is just the ability of the body to actually utilize that protein. And you can overcome that by adding more protein to the mix. The fascinating thing that I did not know until listening last night was he said, for people who are new to training, resistance training for muscle building for them-- yes, you can always, within 24 hours, the signals that are created from that muscle training lasts for up to 24 hours, you can refeed later with protein. If you're new to training, you will get a better effect within two hours post workout. If you are accustomed to training and you've been doing it for a while, those benefits aren't really there anymore. So basically, the more trained you get, the less important it becomes to eat right after working out.

But if you're new to it, it might be more important to eat right after working out. And I was glad to hear that because I had not heard that before. I had been just saying basically the 24-hour thing, which is still true. But I think that's a really important nuance to understand. Something else he talked about and this relates to the question about the kids is apparently kids having little amounts of protein all throughout the day, they actually can utilize that pretty well and that will benefit them, like protein snacks and just that's going to help them. He said for older populations basically said there is no point, really once you're a certain age you've got to get a concentrated amount of protein. And having a little bit of protein here isn't really going to add anything, like it's not going to create the benefits that you want. If anything, it might just be taxing on the system. He came to the same conclusion that Cynthia said, which was, you definitely want to get at least two big protein-rich meals. And the most important ones are the first and last meal. He did say also that you can counter some of the effects. When you get older and you're struggling with the body really utilizing that protein, that's when it becomes even more important to do things which stimulate the hormones to stimulate muscle protein synthesis. Again, that's resistance training. Even fasting is counterintuitive as it may seem, but maybe not to our audience because we talk about that a lot. Fasting actually does, prime the body to have a growth stimulus once you actually do start eating again, which is super awesome.

Yeah, and then also they talk about, I know, there are a lot of people who follow for various reasons vegetarian and vegan diets. I completely respect everybody's opinion on that and why they do that. If you're doing it purely for health reasons, and not for personal ethical reasons, I would reevaluate that the more and more I learn about animal protein and its role in the human body, and especially listen to this episode with Don Layman, he really makes the case just how much more suited that is to the human body. And it provides the amino acids that we really need. He also talks about the specific amino acids that are key for muscle building, specifically leucine as well as methenamine and those are going to be higher in animal products. And then something else, I did know this, I don't think it's talked about enough in the vegetarian and vegan world. We often will look at herbivore animals and say, well, they're eating all like a plant-based diet. And they have like, they're super muscular, gorillas and cows and things that. What's really important to understand is that they could have a certain type of gut bacteria that actually ferments plant-based protein and fibers. I don't even know if it's necessarily protein. It can ferment is plant substrates into protein compounds that the animal then can use and we don't necessarily do that. I think that's really, really important to keep in mind, that was a tangent, any other protein thoughts.

Cynthia Thurlow: No, I think that the biggest takeaway for everyone irrespective of what nutritional philosophy they embrace is the importance of protein. Protein, protein, protein is so important. And I find after working with thousands and thousands of women, when women tell me what they're eating, more often than not, they're really undereating protein and they're wondering why they can't build muscle. They're wondering why they're losing insulin sensitivity irrespective of the life stage that they're in. And I just remind them, this is really something that we can lean into. And it doesn't mean that you go from eating 40 grams total a day to 100. But it's something you can be diligently work towards every single day to get to a point where you're going to garner the best benefits.

Melanie Avalon: Exactly. Alrighty.

Cynthia Thurlow: Next question.

Melanie Avalon: I will just comment one last thing. She said she was excited for her Lumen delivery, if listeners are curious what that is. Do you have a Lumen?

Cynthia Thurlow: I do?

Melanie Avalon: Yeah, it measures the levels of carbon dioxide in your breath to ascertain if you are burning carbs or fat and then it helps make macronutrient recommendations to help you take charge of your metabolic health. Do you have a code for them, Cynthia?

Cynthia Thurlow: I do. It might be CYNTHIA, will have to double-check them.

Melanie Avalon: Okay, we can put both in the show notes. I know mine is melanieavalon.com/lumen and while it changes around right now the code is MEL M-E-L that gets you $100 off, which is amazing, but sometimes it changes. If you want to check the most recent code, you can actually have a Facebook group for Lumen as well as for CGMs and Biosense, which is a ketone device. So, just go to Facebook and type in Lumen Melanie Avalon, and that should come up. So, Okie Dokie. Shall we go on to our next question?

Cynthia Thurlow: Yes. Our next question is from Moose and the subject is: Struggling with intermittent fasting. “I first learned of intermittent fasting about six months ago when my yoga teacher suggested I check out the Delay Don't Deny Facebook group. I ordered the book since I've also ordered Fast. Feast. Repeat and I'm reading that as well. I have been listening to the podcast also. I've been attempting intermittent fasting since then and did have a hiccup. For a phase I was drinking Laqua because I thought that was allowed but I learned otherwise and quit that several weeks ago. I have been drinking black coffee and water and doing the clean fast, I know no gum, mints, etc., or anything with flavor. But I really struggle with being so hungry and my tummy growling, I have been tracking my fasting and on occasion I make it to 16 hours, but often I get hangry before then. I'm just wondering if this is common since most of the stories I hear on the podcast people share they have no problem. And it was easy for them to go 18-plus hours early on. I feel like a failure and I'm frustrated. I believe in fasting and the health benefits and want to embrace it completely and lose weight. And I'm not in a hurry but I know that what I am doing, only making it 12 to 16 hours is more for maintenance and not weight loss. For reference, I am 5’6” and currently about 170 pounds and 45 years old, I would like to lose at least 25 pounds. Thank you much for any support or advice.”

Melanie Avalon: Thank you for your question and whenever we get a question like this, I always think it's a little bit telling or noteworthy when people tell us about their fasting experience and issues with either hunger or not working, and then there is no mention of what they're eating, so it's just about fasting. And to me that says I think a lot of people look to fasting and they think fasting, all of the magic is in the fasting, but there is much magic in what you're eating as well. And this actually piggybacks pretty nicely off of the question right before this. Because if you're experiencing hunger, addressing what you're eating could possibly help that a lot. So, are you eating a high protein or moderate to high protein diet in your eating window, making sure that you actually are getting in the fuel and the substrates that you need? So, we'll make it much more likely that you won't be as hungry while eating. Also, the actual macros of what you're eating can be really helpful, so some people do really well with low carb, for example, and they find that when they go low carb with their eating choices, it actually really, really helps their hunger in the fasting period. Some people, it's the complete opposite. they try to stick out this low-carb situation, and they just never feel full. And then they add in carbs. And that's magic for them. I personally follow a-- and I always wonder how many people think I'm low carb, I eat a really high-carb, low-fat diet. That's all whole foods, it's really high protein. But I basically eat a ton of like, and I'm not saying everybody should do this, because I think everybody should find what works for them but like, for me what really works is really high protein from fish and shellfish and chicken and steak, lean cuts of all of that. And then, I eat a lot of fruit and it works really well for me, and I do the fasting. But some people do really well with low carb. Their handle is Moose Elk, so Moose Elk, I would look at your eating and what you're doing there. Yeah, I would really look at the eating honestly. Do you have thoughts, Cynthia?

Cynthia Thurlow: I do and I'm not 100% sure if this is a male or a female, I'm going to assume a female and just speak from the perspective of if you've been doing this for six months, and you're still struggling to get to more than 16 hours, then something needs to shift. It may be that you're not eating enough in your feeding window. It could be as simple as you need larger portions of protein which is going to help with satiety like Melanie mentioned there needs to be a degree of experimentation. You're also if you're a female, you're in this perimenopausal range and it is going to get a little more challenging, it does not mean impossible to fuel weight loss because you're having these fluctuations and progesterone and estrogen. This is a perfect example of, really leaning into what's your stress management like, how is your sleep? Are you consuming an anti-inflammatory diet that could be, removing inflammatory foods like gluten, grains, dairy, and yes, dairy can be inflammatory in certain people alcohol, sugar, I would definitely try an elimination diet to see if maybe there is a food that's inflaming you I do find for a lot of perimenopausal women that gluten and dairy, in particular, can be problematic as well as alcohol, making sure you're lifting weights. I don't know if you're doing any weight training that is certainly very important that will help with insulin sensitivity. But I do find that perimenopause is a particularly challenging time. Sometimes people are over fasting and that's driving problems. People are eating too many nuts and too much cheese which is easy to overeat. I think you really just need to look comprehensively at what you're doing and make some adjustments and know that no one should have to white-knuckle fasting. If you're really struggling then I would break your fast and eat.

But I would also really make sure you're eating the food and the meals that you're consuming. Melanie and I are very transparent about the way that we eat. I eat a lot of protein. I generally carb cycle which means I don't eat the same amount of carbohydrates every day. I really like berries a couple of times a week depending on how much I'm lifting, I may have squash or sweet potato. I really try to stay away from grains because they generally don't agree with me. But I think for each one of us, it's leaning into what makes our bodies feel good. I do better with leaner meat and leaner fish than I do with fatty fish and fatty meats. And I've been consistently that way my entire life, but I would encourage you to really, maybe keep a food diary, maybe do a whole 30 to figure out what's going on. And the other thing that I would say is because you're 45, I would make sure you have baseline metabolic health markers done. What's your fasting insulin? Do you have a glucometer? Or do you have a CGM, continuous glucose monitor I am really looking at the nuances and we will link up some of the more popular podcasts I've done talking about perimenopause, one of the top five podcasts this year was with Dr. Tabatha Barber. And we'll include that with the show notes so that you can listen to that at your leisure. But perimenopause is a time when a lot of things have to change. I'm obviously a living example, I tell everyone that you can navigate your 40s and 50s and still be metabolically healthy and flexible. But you have to make changes and that's the most honest answer I can give you.

Melanie Avalon: That was very helpful and very comprehensive. Thank you.

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Melanie Avalon: Shall we go on to our next two questions?

Cynthia Thurlow: Absolutely.

Melanie Avalon: We have two questions from Robin. She says, “I am a 67-year-old female doing IF since August 2021. I'm 5’7”, my starting weight was 188, my current weight is 155, and my goal weight is 145. Number one, what protein powder do you recommend? Can I mix it in Greek yogurt? I find it hard to consume enough protein in my four to eight-hour eating window.” Do you have a recommended protein powder?

Cynthia Thurlow: I do if you tolerate whey, I like MariGold, It's New Zealand small batch whey. They have chocolate malt, they have vanilla, they have unflavored and that's my preferred whey protein. If you're going to mix it, I would do full-fat Greek yogurt. But I would also make sure that that's not the only protein source you're getting in your window. You really should have an eight-hour window to make sure you're getting no less than 35 to 50 grams of protein in boluses. I think that's super important.

Melanie Avalon: Yes, so basically refer to the earlier questions about all of the proteins. I had Dr. David Minkoff on the show. I really like his perfect amino protein powder. If you go to melanieavalon.com/perfectamino, the coupon code MELANIEAVALON will get you a discount. Beyond that, I eat much just real protein, I don't ever eat really protein powders. But if I do eat protein powders, I encourage listeners to look at the ingredients on the protein powders, because there are many on the market and they're full of just gross stuff, like additives and flavors and just things you don't want in your body. So, finding protein powders that are really just the source of the protein is, in my opinion, really ideal. So, that PerfectAmino is literally just aminos essentially. There are some nice grass-fed whey proteins on Amazon that I've ordered before. I also like single ingredient like egg white-type protein powders. And yes, Cynthia said, of course, yes, you can mix it in your yogurt.

Cynthia Thurlow: And that will definitely bump up your protein and MariGold is great. It's a small company and if you use code, CYNTHIA, you'll get free shipping on it. But that's probably my best recommendation. If someone's listening that's plant based. There is a lot of junky plant-based options that are out there, but Food Babe’s Truvani is probably the cleanest that I've seen for people that are looking for a plant-based option. I personally don't love it because it doesn't mix very well. But I've tried everything, everything I've recommended, I've tried including the whey protein, although I have to be careful with that because I'm dairy-free and dairy doesn't always agree with me. But I think if you're tolerating dairy that is a nice option and if you're looking for a lower likelihood of immunity, evoking immune response, you can look at Tera’s whey T-E-R-A, Tera’s whey. They have a sheep milk protein that is super high-quality small batch and you can purchase that pretty readily and easily as well.

Melanie Avalon: And here's a huge question for you, Cynthia. I'm super excited for when you release your creatine powder. So, creatine is an amino acid. Is it something that people use for their protein intake? Or is it a more specific use not really related to protein intake numbers?

Cynthia Thurlow: Yeah, it's an important question. It's to be used in addition too, we know that women's creatine needs to change with their menstrual cycle, they actually increase if you're vegetarian or vegan. And there is a lot of really good research to demonstrate that creatine is absolutely critical with menopausal, perimenopausal women, so there is really no one that doesn't need it to help with ATP production, to help with healthy muscle maintenance, to help with cognition, and brain health. And I was telling Melanie before we started recording that we're getting very close, hopefully next month the creatine will be available and I'm really excited because the more I learn about creatine, the more I realize that we should all be adding this as a supplement. So, you can throw it into things like a smoothie, you can throw it into water, it's going to be very multifunctional and no junk.

Melanie Avalon: I'm so excited especially because I keep hearing people talk about it. And I do think it's really important. I've never personally used it and I can't wait till you have yours because I'm going to integrate it into my personal arsenal.

Cynthia Thurlow: Thank you.

Melanie Avalon: All right, second question from Robin. She says, “I've been on bioidentical hormone replacement therapy since I went through menopause at age 57. I still have a uterus, so I take estrogen and progesterone sublingually as well as topical testosterone. In the past when I took too much estrogen, I bled some, so now I take a lower dose. My gynecologist told me I have a hypersensitive uterus. I've even considered a hysterectomy. I won't have to worry about this. My question, “Can I do bioidentical hormone replacement therapy for life?” And all your podcasts I've listened to on hormones I haven't heard this question addressed. Also, what do you think about a hysterectomy for my situation? Thanks, Melania and Cynthia. I love you ladies. And I'm thankful for you both.” And she is from Florida. I hope all is well with her with that hurricane situation.

Cynthia Thurlow: Exactly. Well, Robin, thank you for your thoughtful question. First and foremost, a lot of the research and this is not medical advice let me just say that upfront, just based on what you've shared. I really oral progesterone that actually is much more protective of the uterus, so that might be something worth discussing with your GYN. I don't think it's so much that you have a hypersensitive uterus. I just think there is a right dose for you. And perhaps you and your GYN have not finetuned that enough yet. Yes, when estrogen and progesterone are not properly balanced, it can cause you to have some bleeding which, of course, is not fun in menopause, of course. In terms of whether or not you can take bioidenticals for life, the research is now suggesting that it is safe to do so. There are just many benefits. I think for a lot of women, they go a period of time greater than three to five years after going through menopause before starting the medications, starting hormone replacement therapy. And there is some research to suggest that the most benefit is garnered when it started within three to-- there is a beautiful three- to five-year window after going into menopause when you've utmost benefit from starting it. But that does not mean if we have a listener who hasn't started it in that window that there are not benefits. We know there are a lot of benefits, especially because we think about brain health, heart health, bone health, cognition, vaginal health, etc. I'm glad that your GYN is comprehensive because you're also on testosterone, which is also very important. And for people that are listening, the more you learn about testosterone and the benefits of that it's very, very important for maintaining healthy body composition.

Although it can be tricky because some healthcare providers do not offer that as an option. Your second question is what do you think about a hysterectomy for your situation? I would have to really be at a point where I was having a lot of bleeding to consider going through a surgical procedure although hysterectomies can now be done through the vagina, so they can be pretty benign. That's probably a better question for your GYN. Some women think it's no big deal to have their uterus removed. Others are very sensitive to having their uterus removed emotionally and otherwise. And so, I think that's a highly personal question. But with dosage adjustments, hopefully, you will not have any more bleeding and that will not be problematic, and you will avoid having to have a surgery. But I'm grateful that it sounds like you've got a very comprehensive GYN that they're so on top of not only your symptoms but helping to take care of your brain, body, bones, and heart in menopause. Melanie, what are your thoughts?

Melanie Avalon: Yeah, just a few quick things. We've talked about this on the show before. But every time the question of bioidentical hormone replacement therapy comes up, I do think it's important to share the information about how a lot of the potential fear surrounding bioidentical hormones was based on studies that have since been reevaluated and that they're potentially misleading in the cancer risks for women related to this, just something to consider. it could be really beneficial for a lot of people and I think a lot of the concerns and fears surrounding it might be based in some misleading data that happened with, was it the Women's Health Initiative?

Cynthia Thurlow: Yeah, that came out in 2002 and we have a whole generation of providers and women who are fearful to take hormone replacement therapy. I did an excellent podcast with doctors Avrum Bluming and Dr. Carol Tavris earlier this year, which we'll link in the show notes. There is a fantastic resource called Why Estrogen Matters. And I have to honestly tell you that that book is life-changing. I can't tell you how frequently I recommend it, not just for other healthcare professionals that I work with and interact with, but also patients. And I think it's very important that women understand that you don't have to white knuckle perimenopause, and menopause, you don't have to suffer. Your quality of life is hugely impacted by replacement of the hormones that you've lost. It does not mean there is anything wrong with you. I think it's all about honoring each woman and what they want to have done. I worry the most about brain health. I should be completely honest with you. We look at women's rates of Alzheimer's, they go up exponentially when they're in menopause, as we're becoming less insulin sensitive. I just did a fantastic podcast with Max Lugavere talking a lot about this and about his trajectory in his career and the impact of his mother's illness on his decision to really lean into cognition and brain health. And really that's become his life's work. And so, I always say to women that each one of us have to make the decision that makes the most sense for us.

But education and empowerment are absolutely critically important. And I would strongly recommend if you're on the fence or you're feeling unsure, or you're working with someone that's not comfortable prescribing hormones that you work with someone that is and a lot of the clinicians that I've done podcasts with and there are many of them. Dr. Tabatha Barber, Dr. Shawn Tassone. Dr. Bluming is, I believe, no longer practicing. But there are many practitioners Dr. Felice Gersh, who's going to come back on the podcast this fall and we're going to talk all about perimenopause and menopause. There are many heart-centered practitioners, who want women to thrive in perimenopause and menopause. You don't have to do it white-knuckling it kind of like this is this reoccurring theme in this podcast? You don't have to white-knuckle fasting and you don't have to white-knuckle going through reverse puberty. Hopefully that's helpful, Robin but I think you're It sounds like you're in very good hands. And I'm very happy to see that.

Melanie Avalon: Thank you for drawing attention to that. Something I haven't even remotely thought about, not having had that experience of perimenopause and menopause. The only other thing I was going to comment on was, the testosterone piece is just something I want to share. It's with the Women's Health Initiative study thing. I mentioned last episode, how I recently had Doc-Koz back on my show for his new book called Get the Func Out which is a really comprehensive look at seven key hormone systems in the body and how to address that. But he actually opens up the book, and we talked about his story on the show. He went on testosterone therapy, so this is for men. We talked about this, like, I don't know why this isn't more well-known apparently if you're a man and you go on testosterone therapy it can actually lead to infertility, at least while you're on it. So, like, while he was on it, it dropped his sperm to like 0, which he didn't even know is a thing and apparently, it's very, very common. And he was able to reverse it by going off of the testosterone and doing a lot of specific nutritional protocols. And he did say he reversed the fertility issue while he is in this period of maybe wanting to have children, but then he did say, once he after-- when he is on the flipside of children, he'll definitely go back on it because it's the best he's ever felt. I asked him about testosterone supplementation in women and he said that he doesn't really see it.

Cynthia Thurlow: Is he a clinician?

Melanie Avalon: Yeah, he's a doctor. Yeah. And then I was talking with one of my other doctor friends about females and this is why I'm just really curious your thoughts on it about testosterone supplementation in women and he was not a fan either. Have you done it in your practice?

Cynthia Thurlow: Well, here's the thing, and this is going to come. This might be the most strongly worded response this entire podcast listener base has ever heard from me. When men are trying to tell women, this is very much part of the patriarchy. Rarely will you hear me sound this firm about this. When men are trying to tell women that testosterone is not important, we actually have more testosterone in our bodies until we go into menopause than we do relative to estrogen. It is in smaller amounts. But it is very important for brain health, for bone health, for muscle health, to somehow suggest that women don't need supplemental testosterone. And obviously, this is prescription. This is not supplementation. Typically, it's in a cream form. I think on a lot of levels when you have women going into menopause, and they're starting to struggle with body composition changes, they're losing muscle mass, it is a direct reflection of this loss of testosterone and testosterone starts to slowly peter off, unlike estrogen that gets almost you get shoved off a cliff. It can be a precipitous drop, as you're in the latter stages of perimenopause. I always with caution when I hear male physicians suggesting that it's not important. That has never been my clinical experience. Most if not all of the male and female physicians that I refer to and work with and interact with that are GYNs. They're very pro-testosterone for the right person. Obviously, most people in the United States, both male and female, that have low testosterone levels, it's a direct reflection of stress because our body has a hormone hierarchy. They can also be a direct reflection of insulin resistance. And you get this aromatization of testosterone to estrogen. That's why you sometimes will see feminization of men, not because they choose to become more feminized, but it's because their testosterone is being aromatized into estrogen. And I think it's highly personal. I do find most in the functional integrative medicine space talk very openly about using testosterone. It's very much a bio-individual thing.

But the more I learn about the way that hormone therapy has been put on hold effectively since the Women's Health Initiative came out, the more I feel it's important for providers to speak out and just say that most of the women that I see fully optimized in perimenopause and menopause are very likely on some degree of testosterone and I'm not talking about pellets? Pellets are wildly unpredictable. I have colleagues that call it 1920s medicine. Now, if you're someone that gets pellets and you feel good on pellets, great, but I find most women feel good for about a week or two, and then their testosterone levels plummet and they don't feel great. But testosterone is needed for a lot of different things in the body. And although I respect the physicians that you've interacted with, I have to politely disagree and say that testosterone therapy is absolutely part of bioidenticals for the proper individual at the right time. I see a lot of people do really well starting with progesterone and then adding in testosterone if it's needed, and then adding in the estrogen piece, but it's really dependent on your labs, how you feel, the symptoms you're experiencing, and finding the right provider to be able to support your body and your needs and your goals in a way that is aligned with what you're looking for?

Melanie Avalon: Thank you for sharing that. Yeah, like, I'm so new to the whole testosterone supplementation. And it was-- it was interesting that within a very small timeframe, I discussed it with two different doctors. And yes, very interesting that it was the male perspective and so that's really valuable information.

Cynthia Thurlow: Yeah, and I never, like anyone that knows me the phrase, the patriarchy never comes out of my mouth. However, it has been my experience, the more I learn about this time period in women's lives, the more that that really becomes apparent. And I think for everyone listening, finding a provider that can meet your needs is absolutely important. There are some really good books and maybe that'll be part of another podcast where we can unpack that a little bit more and just talk about some of the books that I think are very, very helpful for women. But Why Estrogen Matters is a great starting point to have that conversation with your healthcare professional. And quite frankly, I say this a lot, www.ifm.org I have no affiliation with them but those are functionally integrative medicine-trained people. And you can look in your area, there might be people that are practicing gynecologists or there’re internal medicine physicians, and NPs, and PAs that have an interest in women's hormones and women's health and can meet your needs and you don't have to suffer, so that's the big take home as you do not have to suffer in perimenopause and menopause.

Melanie Avalon: I'm really glad I said that because I'm really glad to hear that answer, so that was very valuable. Thank you.

Cynthia Thurlow: You're welcome.

Melanie Avalon: Quick comment on the patriarchy thing. I wish it would be possible to-- because if you use that word, it feels it comes with all of these assumptions about-- I wish we could just acknowledge it when it actually is existing objectively without feelings of a bias or emotions, but there might just be systems that are from a patriarchy type system manifesting especially in things healthcare.

Cynthia Thurlow: I rarely say that so for listeners to understand that it takes a lot to get me fired up about something. And this is definitely a subject that I feel it is going to be part of my life's work and helping to dispel bad information, bad research, bad results that were reported from Women's Health Initiative and how we effectively have an entire generation of clinicians and women who were fearful to prescribe and then fearful to take hormone replacement therapy.

Melanie Avalon: Awesome. While this was very valuable information for listeners, okay, [01:07:40] a few things for listeners before we go. If you would to submit your own questions for the show, you can directly email questions@ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. The show notes will be at ifpodcast.com/episode288. Those show notes will have a full transcript, so definitely check that out. It will also have links to everything that we talked about and we talked about a lot of things. And you can follow us on Instagram. We are @ifpodcast and I am @melanieavalon and Cynthia is @cynthia_thurlow_. I think that is all the things. Anything from you, Cynthia, before we go?

Cynthia Thurlow: No, just know that keep the questions coming. We're loving all the variety and we appreciate you and all the listeners’ support. It really means a lot.

Melanie Avalon: I echo all of that completely. While this has been absolutely wonderful and I will talk to you next week.

Cynthia Thurlow: Sounds good.

Melanie Avalon: Bye.

Thank you much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing your review on iTunes. We couldn't do this without our amazing team. Administration by Sharon Merriman, editing by Podcast Doctors, show notes and artwork by Brianna Joyner, transcripts by SpeechDocs, and original theme composed by Leland Cox and re-composed by Steve Saunders. See you next week.

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