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Nov 24

Episode 397: Special Guest: Barry Conrad, Real World Fasting, Resistance Training, Quality Food Choices, Protein Needs, Australian Food Vs American Food, And More!

Intermittent Fasting

Welcome to Episode 397 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Vanessa Spina, author of Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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SHOW NOTES

OneSkin: Get 15% off with the code ifpodcast at oneskin.co.

BUTCHERBOX:  For a limited time go to butcherbox.com/ifpodcast and get your choice of 2 grass fed and finished ribeyes, 2 filet mignons or 2 NY strips—for free in every order for a whole year! Plus, get $20 off your first order!

Episode 332: Special Guest Barry Conrad, Allergies, Food Fear, IF & Social Norms, High Protein Diets, Value Alignment & Lifestyle, And More!

Instagram - Twitter - Facebook TikTok YouTube Website

Adjusting fasting for a crazy work schedule

Working out with resistance training

The magic of a good diet

Protein needs

Australian food vs American food

Sugar content in our foods

Connecting with the podcast

Allergies, bitter, and spicy foods

Whole foods

The Melanie Avalon Biohacking Podcast Episode #167 - Mark Schatzker

Wine and other alcohols

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Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.

TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.) 

Melanie Avalon:
Welcome to Episode 397 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of "What, When, Wine" and creator of the supplement line AvalonX. And I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of "Keto Essentials" and creator of the Tone Breath Ketone Analyzer and Tone Lux Red Light Therapy Panels. For more on us, check out ifpodcast.com, melanieavalon.com, and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Melanie Avalon:
Hi, friends. Welcome back to the Intermittent Fasting Podcast.

Melanie Avalon:
I'm Melanie Avalon, and I am here today with a very special guest who is actually a repeat guest on the show. That's how you know he is somebody very special. I am so excited. I'm here with Barry Conrad.

Melanie Avalon:
Barry was first on the show for episode 332, and we decided it was high time he come back and share a little bit more about his intermittent fasting journey and experiences for so many reasons that we will get into today.

Melanie Avalon:
Actually, namely, one of the inspirations was Barry was recently in The Heights at the Sydney Opera House in Australia, which is absolutely mind blowing and incredible and amazing. And I wish I could have gone, but we were actually having conversations while he was in the show about how he adapts his fasting, does or does not adapt his fasting to that crazy lifestyle, and decided we should have him back and talk about all the things.

Melanie Avalon:
So Barry, thank you so much for gracing our show again.

Barry Conrad:
Thank you so much for having me. I'm so stoked to be back. How's it going? How are you feeling?

Melanie Avalon:
I'm feeling good. Like I said, I'll put a link in the show notes to your first episode, where we talked a little bit about your backstory and your history because you've done so many things. You landed a role on Fox's Power Rangers, Ninja Storm.

Melanie Avalon:
Your first feature film was the box office hit the sapphires. Your theater debut was Broadway's Violet, followed by a streak of roles which included Oh my goodness, beautiful, the Carole King musical.

Melanie Avalon:
I'm about to I have not seen that I'm about to see it in a few months here. Do you like that musical?

Barry Conrad:
You're gonna love it so special. You'll know so many of the songs. It's nostalgic.

Melanie Avalon:
I don't know that I, this is so embarrassing. I'm sure I know her music, but I don't know that I know her music. I don't know that it's her music. Does that make sense? Like I saw Jersey Boys and I was like, oh, okay, that's their songs.

Melanie Avalon:
Is it gonna be that situation?

Barry Conrad:
It'll be the same sort of thing because she's a songwriter. So so many of these songs will be like, oh, well, I know that song, but I didn't know it's.

Melanie Avalon:
Okay, kind of like how Taylor Swift writes for other people as well.

Barry Conrad:
had to segue back to Taylor Swift. Melanie is like the biggest Taylor Swift fan, which I'm sure you all know. Anytime, they do know.

Melanie Avalon:
And you also had a role in Neighbors, which that was the, I feel like I know this is not in your bio, but wasn't that like the longest running soap opera in Australia? Did I make that up?

Barry Conrad:
You actually write, yeah, the longest-running TV series ever in Australia drama, yeah, so it's very cool.

Melanie Avalon:
Crazy, crazy. And so, and you're also an ambassador for Panasonic Hawaii, are you okay? I think we talked about that last time. So we can definitely circle back to that as well. But yeah, coming back to the Sydney Opera House.

Melanie Avalon:
So first of all, congratulations. How was the show, the experience?

Barry Conrad:
It was incredible, Melanie, and I actually listen to that tried to wrote Melanie into coming over to Australia, which is like, I only travel for a day. It's like, it's too far.

Melanie Avalon:
I almost came for like one night, me and my sister were like, we're going, we've looked at flights. I told you we looked at flights.

Barry Conrad:
It was incredible. It was so enriching. It was so vibrant. It was a show that I could be present in every single moment of it. This is the first time that I actually felt like I could really enjoy a role and be present in it.

Barry Conrad:
Usually in the past, I've been worried about this or that or whatnot, and this just felt like a chef's kiss. It was just so wonderful. The stories special, the people are special, so talented. It's like a multi-generational story.

Barry Conrad:
Everyone can find themselves in the characters. It's set in New York, my favorite city in the world. I just had a wonderful time, genuinely. It was so amazing. It's only a week since we've closed, so I still feel that processing time of bittersweet sadness, happy, grateful, all the things.

Melanie Avalon:
It's so amazing. It actually is amazing. And I swear I know what it is. It is in the heights not into the woods. I love the song breathe.

Barry Conrad:
I have to tell, okay, I'm shouting out to Olivia DeKalb, and I'll get her to listen to this. She played Nina, my character's love interest, and she sounded incredible. Check her out on Spotify as well.

Barry Conrad:
She's a singer-songwriter.

Melanie Avalon:
Does she have that? Can I listen to her singing that anywhere? Is it online anywhere?

Barry Conrad:
I'm sure it's somewhere or we could try to find it for you. Like there's an archival that was recorded of the show, but she is amazing. So props to Olivia DeKalb.

Melanie Avalon:
It's so amazing. I'm so happy for you. I'm so proud of you. Like I said, while we were talking during it, not to go straight into intermittent fasting, but what was your dietary approach with fasting leading up to the show and then did you adjust it for the show?

Barry Conrad:
I'm not too sure what I said last time, but still what stands for me is I do generally 20 hours a day on average a week. So 20 hours a day of fasting. Leading up to the show, I was actually really strict and disciplined.

Barry Conrad:
I wanted to be match fit, you know, more than ever, because whenever I'm preparing for a role as an actor, I want to be the best that I can be. And this guy's like a 24 year old guy, like, you know, young vivacious doing his thing.

Barry Conrad:
So I wanted to like be right in that zone. So I really tightened up my diet a little bit more. High protein cut back on the ultra processed food. And I was actually working on something else that I was doing a shoot for.

Barry Conrad:
So I was in prime condition. But by the time the show came around, because we're doing so much choreography. I don't know if it's a combination of the curry slash the eight shows a week, six days a week schedule, but I was able to maybe, you know, bend the rules a little bit more for myself.

Barry Conrad:
Like I was able to eat a little bit more, indulge a little bit more and not be as strict with my fasting. So to give you guys context, on Saturdays and Sundays, we have two shows for both of those days.

Barry Conrad:
So in the middle of the day, sometimes I'll have like three meals, like I have like, you know, I have like chicken teriyaki and rice, and I have like fries, I have, you know, maybe like a club sandwich and people are like, how are you eating all this food and sort of staying in shape?

Barry Conrad:
But I don't know, Melanie, you tell me, like, I think is it, do you think it's the output of the energy or do you think it's the fasting protected nature of fasting? What do you think?

Melanie Avalon:
Yes. Okay. So many thoughts. And I knew you were going to flip it on me, but wait. So when you quick clarification. So when you're having the three meals in between shows, that was like your meals, right?

Melanie Avalon:
And then you didn't eat again until.

Barry Conrad:
the next day.

Melanie Avalon:
Next day in general it was always like a daytime meal situation and then and then having a show after.

Barry Conrad:
Yeah, so we'd have a show like a matinee at like 2, 2 30 p.m. We'd eat at like 4, 4 30. And that's when I'd have these like three meals. But I mean, okay, Australian portions are not American portions.

Barry Conrad:
They're not as big. They're not as big. So I was, we needed the energy. So I was just like, I was inhaling the food, but then the next day I'd do the same thing, but just the Saturday and the Sunday I'd do that.

Barry Conrad:
But it seemed to be fine and stay in really good, really good shape. So I don't know. What do you think?

Melanie Avalon:
Well, I love this question and you actually asked it to me. Like, okay, so here's the thing, Barry sincerely asked me this question. We were having a call and he's like, people, he's like, I eat all this food.

Melanie Avalon:
And people are like, Oh, you can't be, you know, eating all that food and blah, blah, blah. Like what is happening here? Two things to approach. One, I would love to discuss the societal disbelief that people have surrounding this.

Melanie Avalon:
And then two, what is actually happening? And for me, as far as like what is actually happening? So I do think there is this magic. When you do fasting and you're going that period for a long time without eating, and then you do have all this massive food at one time, you have better insulin sensitivity, you process the food better.

Melanie Avalon:
You're not constantly in a fat storing state by eating constantly throughout the day and messing with cravings and all the things. I really do think there's some magic here, which displays itself by people doing it.

Melanie Avalon:
But people don't believe it. You were saying people were not disbelieving of you, that you could eat this much. And do they think you were secretly eating otherwise?

Barry Conrad:
I think people look at that, they just look at the volume of the food quote unquote volume.

Melanie Avalon:
Or did you tell them you were fasting otherwise?

Barry Conrad:
I do tell them I said I do intermittent fasting and people nod maybe in confusion like not knowing what that means and then some people nod like knowing what that means but they still don't quite get because I work out three days a week resistance training and that's it for like 30 minutes a day that's it and then I just fast and people don't they were really just skeptical about how is that possible.

Barry Conrad:
You know.

Melanie Avalon:
Yes cause if people will put pictures in the show notes, but if you look at Barry, he looks really great. He looks amazing.

Barry Conrad:
Thanks, Mel. As do you.

Melanie Avalon:
Oh, thank you. Thank you. Thank you. That was the other thing. So the working out. So you're not spending, you said 30 minutes, a couple times a week.

Barry Conrad:
And I just know, like, gym bros, if any of them listen to this podcast, they'll be like, whatever, bro, like, you're juicing up, you're doing something. But I promise you, it's 30, 35 minutes, that's max.

Barry Conrad:
And that's all I do. But it's just intense. And I just do my thing, and I get out. And I don't know how that works necessarily. But it does for me. So I don't know if that's genetics, or if it's the fasting that's sort of being contributed towards that.

Melanie Avalon:
Is it resistance training?

Barry Conrad:
Yeah, resistance training only. And then especially for this show, like prior to the show, I usually we do like resistance training, maybe do a little bit of cardio on the days in between. But that would look like maybe the Stairmaster for 10 minutes max, or a walk by Bondi Beach, which is an iconic beach in Sydney.

Barry Conrad:
Please come visit us. And that's it. It's not anything crazy.

Melanie Avalon:
Well, you're getting so much cardio during the show, presumably, like so much. Here's a question. Before you started doing fasting, what was your gym approach with resistance training and did it manifest differently?

Barry Conrad:
was still not long. It was always that amount of time. It was never like an hour. Some guys spent a couple hours in the gym, like, what are you doing for a couple hours? That's a lot of time. It was always shorter and more intense, rather than a longer period of time and hitting all these different muscle groups.

Barry Conrad:
I do a full body situation every time and that's it.

Melanie Avalon:
Oh, okay. Oh, that's interesting. So you don't alternate full body like to failure.

Barry Conrad:
Yeah, I go to failure as much as I can. And that's it. I just touch on, like, I'll do chest, shoulders, bias, tries, glutes, hammies, calves, and that's it. And I know a lot of people would think that's not enough.

Barry Conrad:
But at the moment, it's working for me. I know I can keep challenging myself. But Brock Ashby, actually, who was on my show at Bento at BC, he's a personal trainer, and he encouraged me to lift a bit heavier.

Barry Conrad:
So I started actually implementing more of that. And maybe that's helped. I'm not too sure.

Melanie Avalon:
When did you start?

Barry Conrad:
I started lifting a little bit heavier probably earlier this year, but I really just do think maybe it's a combination of that, but a lot of it is the way I eat. As you know, Mal, food is so important on nutrition.

Melanie Avalon:
I'm having flashbacks to the old paradigm I used to exist in where I thought I had to like, you know, go to the gym and I mean, we're talking about going to the gym, but like, like I had to like, that it was all in the gym was where the body was made.

Melanie Avalon:
And that was the lever. And when I first changed my diet, which wasn't with intermittent fasting, and it wasn't even with eating like whole foods, it was switching to low carb, that's when I realized, oh, changing what you eat actually has a massive effect on so many things.

Melanie Avalon:
And it's a little bit magical. And then I just started implementing and integrating more things from there. Like you said, I just think there's so much power in the food choices, the food choices, and then also the fasting as well.

Melanie Avalon:
We also talked to you and I about protein, because people have this, people have this fear or this belief that you need to be eating protein constantly throughout the day in order to support or grow muscle.

Melanie Avalon:
And well, I think we can both speak to that because you're not you are not correct. You're not eating protein constantly throughout the day. And you are are you building muscle? Did you build muscle without eating protein constantly throughout the day?

Barry Conrad:
I don't eat throughout the day, a, like I eat in my one meal, quote unquote, one meal a day or one window of food, but I don't eat throughout the day at all. I don't stress about as soon as I put the last weight down, I'm running to my protein shake.

Barry Conrad:
I don't do that too. I don't subscribe to that myth that you need to do that because I believe, correct me if I'm wrong, it's within a 24 hour period, you can consume that protein for it to be effective for protein synthesis and stuff like that.

Barry Conrad:
So I don't stress about that, but yeah, I don't eat throughout the day at all and I don't freak out about it.

Melanie Avalon:
And during that time that you've followed that approach, have you built muscle?

Barry Conrad:
Absolutely. And I also think of the body re-composition. I feel like I'm in better shape now than even like 15, 20 years ago. It's great. It's crazy. I just don't understand how that works. But I definitely the only thing that has changed between now and then is most significantly is the fasting and the nutrition.

Barry Conrad:
That's it.

Melanie Avalon:
Yeah, what I love about this so much is people will say that you need to be eating protein constantly to build muscle. But if we can have examples where people are not doing that and they are building muscle, that means mechanistically, it is possible to build muscle without eating constantly throughout the day, because I build muscle without eating constantly throughout the day protein.

Melanie Avalon:
Actually, Vanessa, I was talking with her earlier today, she actually just interviewed, she interviewed the guy who, I don't know if you saw this or if you, I don't know if this episode has aired yet either on this show.

Melanie Avalon:
They recently have done more research on the whole idea about how long it takes or how much basically the timeline of protein intake and when you can build muscle or not. And they thought it, there was like this window that you had to have protein in and that protein also, after eating protein, it was only anabolic for a certain amount of time.

Melanie Avalon:
And now they don't, they've done research and realized that you can eat a massive amount of protein and it'll still be anabolic for a long time. So kind of flies in the face of what we've thought about.

Melanie Avalon:
So people think that you can't get all your protein at once because the rest will just be wasted. And apparently that's not true.

Barry Conrad:
correct me if I'm wrong because I've heard previously that you could only, for example, like only 30 grams of protein per meal. Is that is that change? Yeah.

Melanie Avalon:
That's been the idea for so long that you can only synthesize and use 30 grams of protein at a meal. And then everything beyond that is like not used for building muscle. And what they've realized, and Vanessa could speak better to this, but what they've realized now is that there's not an end, like it does keep going.

Melanie Avalon:
And one of the reasons that that may be is that the studies, like they would only look for a certain amount of time after eating protein. So they never, they never looked. Like they never looked to see if muscle synthesis continued, which is a big gaping hole in the whole theory.

Barry Conrad:
That's massive. And that's good for me. Because I eat, for example, I will have 500 grams of ground beef at a time, or 1 kilogram of chicken wings at a time. And that's a lot of animal protein at once.

Barry Conrad:
And then I'll also have, for example, a cup or two of Greek yogurt with a scoop of whey protein in there. So that's a lot of protein in one meal. For most people, most people probably get to do. And it's good to know that not all that's going to waste at 30 grams.

Melanie Avalon:
like scientifically, we're not finding that. And like I said, we just see it, like we see you doing it, me doing it, like people are doing it. So clearly, it's, you know, it's working. And did you say, wait, the meals that you eat, are they are they provided by the theater or they like

Barry Conrad:
There's a cafe inside the Sydney Opera House. Sydney Opera House is one of the most iconic gems of Australia. It's incredible. But inside there's this cafe, and they do pretty good food there. It's not provideable, but it's cheaper because it's for the people performing that.

Barry Conrad:
They're not massive. They're not airplane meal size, but they're not my size. As Melanie knows, I love to eat big portions. So three will suffice. Yeah, like you. So one's not enough for me.

Melanie Avalon:
I love it. I just want to come see the show. I know it's done, but I would just like, it would have been a great time, a great time.

Barry Conrad:
There'll be other things, I believe it, there'll be other things. You get to all be performing in the States and you get to come to one of the shows. And the US. Yeah, exactly.

Melanie Avalon:
Yes. Do a tour. Do a tour. Here's a question. Speaking of the U.S., how often have you come to the U.S. and done stuff here?

Barry Conrad:
Well, the last time I was there actually, I did reach out to Melanie and she was like, sorry, I'm good, I'm busy, I'm probably doing a Taylor Swift thing.

Melanie Avalon:
No, you didn't. Wait, wait, no, you didn't.

Barry Conrad:
No, the last time I was there, no, I did make, I did get in touch with her, but- You have never- No. Remember, I was in New York. I was in New York at one point, but then it was just like, I didn't give you a notice.

Barry Conrad:
I just messaged you when I was there and I was like, what?

Melanie Avalon:
Did you ask if I wanted to like meet up in New York? I don't remember this. I have no memory of this. I remember you being in New York. We're gonna plan something next time you're here.

Barry Conrad:
But we're definitely, the next time I'm there, we'll definitely meet up and we'll put something on social media for you to see. Eat all the protein. Eat all the protein.

Melanie Avalon:
Yes. Oh, which I want to, I have questions about that. We're going to like dinner eating and desserts and savory desserts. We're going to talk about that. But I do have a question for that. So when you're in the US and you eat the food here, do you feel any different in your body from eating the food here versus Australia?

Barry Conrad:
180%.

Melanie Avalon:
It's not a leading question.

Barry Conrad:
How do you how do you feel a I love America so much and I can't wait to be living between there and here be I will say that yes there are places that the food makes me feel good but a lot of the places I don't feel as good like maybe it's the produce in terms the animal protein side of things is a bit different but you have to hunt you have to find good spots good quality you don't want to just eat you know I'm not gonna say names but just fast food places and stuff like that obviously it goes without saying but what about you do you find like you have to really source do you look at websites and go okay this is what they use or like you just sort of get to the restaurant and go hmm what can I have that I know will not upset my gut situation.

Melanie Avalon:
This is such a good question. Before that, one quick question. Do you have fast food in Australia? Do you have McDonald's? What? No, I'm sorry. I just Australia is like really far away. I don't know.

Barry Conrad:
Like I said, do we like, you know, have koalas as pets next? Is that the day?

Melanie Avalon:
Are there kangaroos in your backyard? There are.

Barry Conrad:
Right. It's so weird. Because when I lived in South Africa, people used to ask like, do you did you have to like hunt for your food? I'm like, yeah. And they believe me. Like, no, we haven't done we have all the things.

Melanie Avalon:
there are kangaroos like hopping around, right? I'm not making that up.

Barry Conrad:
Not in Sydney, like very in the countryside, yeah, yeah, for sure.

Melanie Avalon:
Aren't they violent or aggressive?

Barry Conrad:
They can be, so you probably don't want to get out of the car and try to do a waltz with the kangaroo. You want to keep it moving.

Melanie Avalon:
Do you eat them? Are they on the menu regularly in Australia? Because I like kangaroo. Tastes good.

Barry Conrad:
I actually will say I've never seen kangaroo in a restaurant on a restaurant menu, but I have but it's definitely in our supermarket like in terms of like and the meat is really lean the proteins really good so it's great you just have to cook it not too long so it's not.

Melanie Avalon:
Oh, my mind is being blown. Okay, because I I have it here. So I've had it. I found ground kangaroo at the grocery store. So I've had that and then there's a restaurant here, my one of my favorite restaurants in Atlanta, they have kangaroo as an appetizer, and it's really good.

Melanie Avalon:
So I always I thought like kangaroo steaks were like a thing in Australia. And I'm kind of sad now to learn that they're not a thing.

Barry Conrad:
Maybe i just haven't found it but it's not typically now it's fairly.

Melanie Avalon:
It's like the leanest red. It's so cool. It's so cool. It's like super lean red meat.

Barry Conrad:
That's it for Melanie Evelyn.

Melanie Avalon:
Yeah, stock up on it. But to answer your question, I feel like I have to go to a certain type of restaurant here in the US, which is basically like steakhouses or French restaurants or Italian restaurants that have, it sounds so pretentious, that are not like, that are nice.

Melanie Avalon:
And if they're nice, like literally $3 signs, if they're nice, if they're nice, then I can go in and I know I can typically find something on the menu, like a protein that I like, and then I can have the, you know, I can ask for requests to, you know, adjust it for me, and I'll be good.

Melanie Avalon:
And I basically can handle or tackle most restaurants like that and eat it there and walk out feeling okay. Like if I don't make modifications, though, it's a little bit suspect. And yeah, because there's just so many additives and seed oils and all the things.

Barry Conrad:
I can't wait to be over there and actually get a restaurant with you and just to see you in action as you order. So can I please like basically I want it like prepared like this and not nothing.

Melanie Avalon:
I don't know if we talked about this last time, but I have been a server in a restaurant for a long time and fine dining. And so I feel like I understand what they have to go through to do that. So I appreciate it.

Melanie Avalon:
I have gratitude. I ask very nicely. I want to empower people. I mean, you're the customer. You're paying them. They are making money off of you. You have the right to adjust the meal so that you enjoy it the most and feel good.

Barry Conrad:
Oh, trust me, I adjust as well in a way that's polite, obviously, but some people feel uncomfortable with that. To circle back to what you said about fast food, I will actually say, do you know Thomas DeLauer?

Melanie Avalon:
Yeah, I've had him on the show on the Melanie Avalon biohacking podcast.

Barry Conrad:
I saw something on maybe Instagram where you talked about differences in fast food or something compared like America compared to Europe and stuff like that.

Melanie Avalon:
Is it different?

Barry Conrad:
It really is like from Australia. It's I don't know why like but the McDonald's here versus say a McDonald's I've had in LA or whatever it is different it's I mean doesn't mean it doesn't taste better there but the way I feel is completely different.

Melanie Avalon:
It's really horrible here. It's really bad. I remember I used to, because my international traveling experience mostly revolves around Germany, because they have family there, I would always have the Harrybo gummy bears.

Melanie Avalon:
And they're a completely different Harrybo. Do you know that brand? Do they have that in Australia? I don't think so. Guess not. Sad day. I think people here will know what it is. It's a gummy line. It started with gummy bears, but now there's all these gummies.

Melanie Avalon:
It's a thing. Big in Germany, but big here, too. And the ingredients are so different. In Germany, they use natural things to color it. Here, it's all these random colorings. And then here, we use corn syrup.

Melanie Avalon:
And there, I don't know what they use, but it's not probably... It's a completely different formula there versus here. It's upsetting. A lot of people here will say they go to Europe, and they can eat the grains there, and they don't have the reactions to bread and things like that.

Barry Conrad:
other than restaurants in America, I've actually never gone out and bought a loaf of bread there because I just...

Melanie Avalon:
in America?

Barry Conrad:
Yeah, it really is different. Over here in Australia, the sourdough bread is so good. Generally, the bread's pretty good over here. I don't know what it is in the water over there. Also, I'm not generalizing.

Barry Conrad:
Not everyone has bad bread in the United States of America, but it does feel different from my past experiences so far. That probably will change.

Melanie Avalon:
Well, here's a fun fact for you. Are you ready? I learned this this week. So in Ireland, Subway bread does not qualify as bread. What? Yeah. Because of the sugar content, because it's full of sugar, it was too high for the country's legal requirements for the food to be called bread.

Melanie Avalon:
So instead, in Ireland, Subway bread is classified as confectionaries.

Barry Conrad:
That's wild. That's crazy.

Melanie Avalon:
That's telling is what that is. It's telling.

Barry Conrad:
It's scary because a lot of parents for example would be like no let's have a sandwich like this is healthy and it's not because of them. You know turning a blind that's that's because we're told it's fine to have bread but no breads the same.

Melanie Avalon:
It's like full of sugar. That's crazy. It's crazy. It blows my mind, and I think about this more often than I should, but breakfast cereals here in the US, it blows my mind that this is what is taught to us as the thing to start children off with for the day for a healthy start.

Melanie Avalon:
And you look at all the breakfast cereals, and it's like ADA approved, like American Heart Association, good for your cholesterol, healthy multivitamins, minerals, eat this now. And it's literally sugar.

Melanie Avalon:
They get sugar down their throat.

Barry Conrad:
It wasn't that spirited by a brand. I'm not going to say the whole number K, you know, substitute K.

Melanie Avalon:
Vanessa and I talked about this on a recent episode, which probably hasn't aired yet, but we talked about how—actually, by the time this comes out, it will have aired—but we talked about how basically Kellogg's—that's the name.

Melanie Avalon:
There's a whole history to it—but basically, Kellogg himself, the reason he created it was because he wanted—it was a moral thing. He wanted to stop men's sexual desires, and he thought that this bland food would stop their libido, which is kind of telling.

Melanie Avalon:
So that's fun fact one. Fun fact two—so many things. So have you heard the phrase, breakfast is the most important meal of the day?

Barry Conrad:
Yeah, who hasn't? That's what we're told, right?

Melanie Avalon:
Guess who came up with that?

Barry Conrad:
Mr. Kellogg?

Melanie Avalon:
Kellogg's, it was a marketing thing. We were told this as health mantra of life and literally it was marketing. It's so upsetting. It's really upsetting.

Barry Conrad:
It's upsetting and also just the power of marketing, like that's amazing for what they wanted to achieve because they achieved it, but it's just like, wow, like everyone lives their life by that because of that.

Melanie Avalon:
In Australia, do they have these breakfast cereals marketed heavily to kids?

Barry Conrad:
Cocoa pops can your cornflakes every like it's the whole yeah, it's everywhere. Of course. Yeah, it's really upsetting. So

Melanie Avalon:
Here we are.

Barry Conrad:
When I go to the States and I'm staying at a hotel, for example, and I typically don't have like breakfast, meaning like early in the morning. But when I do, I'll definitely do it at the hotel because it's like it's the buffet and stuff like that.

Barry Conrad:
And when I do that, I'll just smash the eggs, try to find because the bacon over there isn't typically great. There's usually biscuits and gravy and stuff like that. So I'll just try to go poached eggs, tomato, mushrooms and stuff like that.

Melanie Avalon:
Here's a question. So when you are traveling, do you, because I'm kind of jealous of you because I'm so intense with my intermittent fasting, I have to do it, like I have my system, I do it the same way all the time.

Melanie Avalon:
Even if I'm traveling, are you more fluid? Do you adjust? How do you do traveling?

Barry Conrad:
It depends what the purpose of the travel is for. If the travel is for a work trip, I will typically try to stick to my protocol. But at the same time, if I'm in town and people want to take me out somewhere, I'm not going to be religious about it and say, sorry, the clock is still at 16.49.

Barry Conrad:
But if it's like a vacation, I'm going to not be crazy. I'm not going to go to the extreme, but I'll definitely enjoy myself. Because I know that I believe it's what you do most of the time. And I feel like that is protective.

Barry Conrad:
I don't know how that works, but I do think that your body sort of thanks you for doing what you do most of the time. So when I get back home, I'll just jump strip back in and I'm the type of person that can sort of just go cold turkey, meaning like I can just switch really easily.

Barry Conrad:
I can go into a couple of weeks of just like not fasting if I wanted to and then just jump strip back into fasting and not... I think it's just practice. At this point.

Melanie Avalon:
I'm the same way, not that I do always do the fasting, but I'm the same way with the cold turkey, like extremist. I can just, with things in life, I can just go all in really intensely either way. I don't have to like build up to it and I don't do good with moderation.

Melanie Avalon:
Oh, do you remember the first time you consciously decided to try intermittent fasting?

Barry Conrad:
I've actually been trying to wreck my brain for this answer because I think I don't know, Mel, I've been trying to figure I know it's been a good five, six years now since I've done it. But I don't know the first exact moment like it wasn't like a penny dropped in something I don't know.

Barry Conrad:
But I did. I do know that I started with 19 hours. I started there. And you clocked it on the clock. I did. I feel like I started listening to your podcast when you were doing it with Jen Stevens. And I was like, what the heck is this thing?

Barry Conrad:
What? I just I was because I'm always fascinated with

Melanie Avalon:
How did you find our podcast?

Barry Conrad:
I don't know, I just, I was looking for health and fitness topics on Spotify, and I think I was at the tail end of doing a show at the time, I was like, oh, what can I listen to? And that came up, and it was really interesting.

Barry Conrad:
I was like, oh, listen to this. And then, to be honest, your show, this very show that I'm on right now, was a major catalyst for me really sticking to it. And I'm not just saying that just to say it, like it really was a pivotal, because the stories were great, the science was great.

Barry Conrad:
I loved the banter between you two. It was just really informative, really relatable, and not too sciency, but also had science enough to back it up, so it wasn't just like some cult or something, you know?

Barry Conrad:
So it was great.

Melanie Avalon:
Oh my goodness, it makes me so happy.

Barry Conrad:
So it's actually quite actually, to be honest, Mel, it's surreal to be on your podcast. I know that we've known each other for a while now, but I want to say thank you because this podcast actually has been a major contributor towards me sticking to what I'm doing and has taught me so much about fasting.

Barry Conrad:
So thank you.

Melanie Avalon:
Oh my goodness. Thank you so much. Thank you for sharing that. And that just, it makes me, I'm so honored and happy. And I love hearing that because it's really nice to know that, because I feel like with this show, I mean, it's like, I know it's been a long time.

Melanie Avalon:
And when we're recording podcasts, it's just you and the other person who can't even see because I refuse to do video. And so you don't see like all the people who may be listening and how it may be affecting them.

Melanie Avalon:
So thank you for sharing that. Oh my goodness. That's crazy.

Barry Conrad:
It is crazy, actually.

Melanie Avalon:
think we talked about this last time. I don't know how we even connected originally. I think you were maybe sharing stuff about the show on Instagram.

Barry Conrad:
Instagram yeah that's gonna be me but i definitely hundred percent no in twenty nineteen i was listening to the show that's my first time listening to it.

Melanie Avalon:
Oh my goodness, crazy pre pandemic era. That's crazy. Oh, that's that's a question. When the pandemic happened did, because I know for a lot of people, well, people reacted all different ways. But I know a lot of people actually, it actually helped their health journey because they like, you know, were able to actually like tackle things.

Melanie Avalon:
How did the pandemic affect you when it came to your health and dietary choices?

Barry Conrad:
It was it goes without saying that it was really rough. I mean, for me, personally, it was really tough.

Melanie Avalon:
especially in your industry, because your industry like shut down.

Barry Conrad:
The industry shut down here in Australia, and I'm sure in the states as well, you know, so it's like, how am I going to get through this, you know, it was really stressful. I did probably turn a bit more to a little bit more ultra processed food at the same time, I still did not deviate from my fasting protocol.

Barry Conrad:
And I do believe that was protective. And I still kept up on workouts. I am a pretty self motivating person. So I, in the face of stress would rather say I'm not going to take this so like double down on what my whys are like what my goals are.

Barry Conrad:
So even though it was tough, I stuck to generally what I'm doing now. But I probably did allow a bit more wine, a little bit more comfort food, quote unquote, you know, during that time. It's very isolating.

Barry Conrad:
What about you? What how did how did you handle that time?

Melanie Avalon:
So I was really grateful that my job, everything I was doing was all, it was like podcasting and it was stuff that didn't rely actually backtracking. It actually was a really beautiful moment for my life because I was still, I mentioned earlier doing restaurant jobs.

Melanie Avalon:
So I was still doing a restaurant job when the pandemic happened. And I had gotten to a point with the podcasting and everything that I didn't actually need to be doing the restaurant job financially, but it felt safe because I was clocking in somewhere and I got a paycheck.

Melanie Avalon:
That felt safe. And it was really scary to think about doing everything on my own as an entrepreneur, as a podcaster. That was terrifying. And so I knew for a long time that I should quit my restaurant job and just focus 100% on this type of stuff.

Melanie Avalon:
And I honestly, the pandemic happened and then I lost the restaurant job because they cut people. It was actually a beautiful thing for me because I'm really curious about how long I would have stayed in that.

Melanie Avalon:
And I'm completely like, people need the jobs that they have and I was in it for a reason and I support people doing all of that. But for me, at that time in my life, I didn't need to be there anymore, but I was scared to let go of the security blanket that it gave me.

Melanie Avalon:
And so the pandemic happened, I lost it. And then I realized, oh, I actually don't need it financially and I can be doing these other things. And so it was actually really good. It's amazing. Yeah. It was actually really, really helpful for me for committing finally, because it's scary to be...

Melanie Avalon:
I mean, you know, it's scary to be living on your own, not clocking in somewhere.

Barry Conrad:
hundred percent relate to that and it is tough because it's like what's going to happen but you actually yeah you know the magic actually the magic happens more when you actually make that choice to leave and i'm sure that you can attest to that like things open up more it just happens

Melanie Avalon:
It's so true. I remember literally when I lived in LA, my hairdresser told me one of her client, her other clients was like a bartender, and then I'm probably like an actor or something. But she told me like, once she quit her job and like committed 100% to this other route, that's when it really took off.

Melanie Avalon:
And I saw that for me as well. And everybody has their own path. But for me, that's what was really, really helpful.

Barry Conrad:
Does it affect your fasting protocol and or your nutrition or not really?

Melanie Avalon:
No, fasting and the way I eat has been something that has provided, like it makes me feel really good doing it and it's provided a really nice anchor and stability. And so I didn't, I didn't change it during the pandemic and I'm really grateful for that.

Melanie Avalon:
I remember actually, do you know my David Sinclair story about this by chance? Do you know David Sinclair? Of course, yeah. So he was one of my first guests on the Melanie Avalon Biohacking Podcast and he's a legend.

Melanie Avalon:
He kind of discovered resveratrol, he didn't discover it, but he popularized resveratrol, oh, which we have to circle back to wine, but that's one of the anti-aging compounds in wine. And he had a book called Lifespan, which is one of my favorite books ever.

Melanie Avalon:
And so I had him on the show, on the Melanie Avalon Biohacking Podcast early on, like when it was barely anything, barely any guests. And I just emailed him to his Harvard address and I was like, do you want to come on my show?

Melanie Avalon:
And he was like, sure. And that blew my mind beyond belief. But when the pandemic happened, so I don't know if you remember, do you remember when the pandemic happened and there were all these podcasts about the pandemic?

Melanie Avalon:
Do you remember that?

Barry Conrad:
Yeah, it was like it's very sensational as it was like a thing was a moment.

Melanie Avalon:
Yeah, like all the podcasts are about it like everywhere. And so I was like, I feel like I need to do an episode on the pandemic because everybody's doing an episode on the pandemic. And this was before it got political, like you could actually do an episode and not feel weird.

Melanie Avalon:
So I reached out to David and I was like, do you want to come back on for an episode on the pandemic? And he was like, sure. Just like mind blowing. And again, that was before it was political. So he came on.

Melanie Avalon:
But the point of the story is I remember one of the things he said on that episode was that this could be an opportunity. Like he was talking about like health and lifespan and everything. And he was saying that this pandemic situation, like this is an opportunity for people to actually come out healthier on the flip side.

Melanie Avalon:
Like you have choices you can make now. And you could use this time of being away from society and your normal thing and all the stuff and actually, you know, work on your diet, go to the gym and like come out even stronger.

Melanie Avalon:
And I'm paraphrasing, of course. But I thought that that was so inspiring. I feel like that's the way it was for me.

Barry Conrad:
I actually really relate to that as well, like creatively, I actually got so much out of it as well, like, writing and things like that. So I get that, like, you know, it was a good like, what other choice did you have, but to, okay, the option is either to bow down and just, you know, be on the bathroom floor, or what, what can I do in this isolation sort of thing, right?

Melanie Avalon:
Well, yeah, because to that point, and I think one of the problems with modern society is because of the way food has been created to satisfy, like literally instigate all of our feel good neurotransmitters in our brain, it was so easy, and I understand why, to turn to these processed foods and everything as comfort and nourishing, because that's literally how it's designed.

Melanie Avalon:
It's designed to make you feel good. So for a lot of people, I think that became, you know, there was the whole, like, what do they call it? Like the pandemic, because there's like the freshman 15. There was like the COVID 15.

Melanie Avalon:
I don't know. I can see how there was different paths for different people. I'm really glad we're on the flip side.

Barry Conrad:
I'm so glad travel to travel as well if you can go anywhere.

Melanie Avalon:
I know. And it was crazy in Australia, right? I feel like you guys were like the most intense.

Barry Conrad:
We had like, I don't know what it was like there, but five kilometer radius. So basically you could only walk within five kilometers, like to the park or. Yeah. We had like a 5k radius that we could explore from our houses.

Barry Conrad:
We kind of go beyond that. It was just, it was insane. It was a lot. So I thankfully was living.

Melanie Avalon:
Are they monitoring that?

Barry Conrad:
or that was like on our code. No, they're monitoring it. There was cops out on the south spot. How do they monitor it?

Melanie Avalon:
But how would they know where you were from?

Barry Conrad:
They would basically stop you and say, where do you live that are like, yeah, as intense and so thankfully, I was living by the ocean and I was able to just take ocean walks that really got me through, which is what is part partially when inspired.

Barry Conrad:
My song ocean road to shameless plug right there.

Melanie Avalon:
Oh my goodness, really? Wait, I have to listen. Ocean Road, OK, putting in the show notes. I'm going to look after this.

Barry Conrad:
As you said, cloudware on the flipside.

Melanie Avalon:
So, you know, I eat a lot of natural, real foods, a lot of cucumbers and such and blueberries. So like my normal buying habits are to go to Costco and buy like 15, three packs of cucumbers, like 10 bags of blueberries.

Melanie Avalon:
Like I buy a lot of the same thing. And yeah, it's like a whole thing. Like they know me there. Like they really know me there. It's kind of crazy. So like the pandemic happened. So I would like go places and buy what I normally buy.

Melanie Avalon:
And you know, there was like the idea of like people were like stockpiling. And I felt like I needed a sign that was like, no, I always buy 50 cucumbers. Like this is my normal habit. This is not like I'm not freaking out.

Barry Conrad:
who's the blonde lady she's like she's stealing all the stuff we need

Melanie Avalon:
Like, he's like stockpiling. No, I'm not stockpiling. This is just how I shop. I'm sorry. So

Barry Conrad:
I'm just trying to get a visual of you buying all of these cute, do people look at you funny when you do that?

Melanie Avalon:
Oh yeah, no, they know me, like they know me. For real, like they know me. It's a thing.

Barry Conrad:
a lot of skelops, right? You love skelops, that's your thing.

Melanie Avalon:
Scallop yeah so basically it's scallops blueberries and cucumbers and massive amounts and if I don't buy the scallops one day they'll be like where's the scallops and if I don't buy the blueberries like where's the blueberries.

Barry Conrad:
Okay, Team Blueberries, Team Cucumbers, I haven't bought that many knee scallops, but I do like them. I do like them though, but they're expensive too. They're not cheap.

Melanie Avalon:
Fun fact for the audience, Barry, not scallops, but in the same family of shellfish, Barry was reacting allergicly to shrimp and decided he liked shrimp too much for that and he was going to fight his way through.

Melanie Avalon:
I love this story. So you like deconditioned your body to shrimp, right? Like you can eat shrimp now.

Barry Conrad:
I don't know how it's possible but i Melanie is exactly right i would literally blow up my neck and face would expand and break out in hives every time i had shellfish it's so crazy like actually scary, what my stubbornness of not wanting to give up the enjoyment of this room like friends like i'm not giving this up.

Melanie Avalon:
like small amounts no no oh you just go big but you're good now i'm good now okay so when you visit we're gonna have a shrimp cocktail as an appetizer

Barry Conrad:
Do you know that I've actually never had one of those before? I know what they are. Don't, don't yell at me. I know. It's like one of my favorites. I know what it is. I just, it's not a thing here in Australia really.

Barry Conrad:
Sadly, it's not.

Melanie Avalon:
Okay, so okay, we're gonna have one of those.

Barry Conrad:
been talking about shrimps aka prawn, we call it prawns over here.

Melanie Avalon:
Oh, you call them prawns? Yeah. Whenever I think of prawns, I think of that Cloverfield movie or no. Do you know that movie? Which one? Oh, District 9. With that movie, I think of District 9.

Barry Conrad:
Hi, Prawns. Often I'll go back to fasting geek territory, like I would often open my window with a plate of prawns, aka shrimp, with salt and pepper, maybe a little bit of mayonnaise or peronnaise, and some wine.

Barry Conrad:
So it's really refreshing. Peronnaise? Peronnaise, I don't know if they have... It's kind of like a spicy mayonnaise, kind of like... Whoa, I don't think we have that. If you don't have either a hack to make it, so it takes some normal mayonnaise or a healthy mayonnaise and just basically thrash it with cayenne pepper and you just spice it up and you just dip that in there with a little drizzle of lemon and you're good to go.

Melanie Avalon:
That's good. Okay, I'm not a big Kyan fan, but it sounds sounds interesting. Not a spicy. Yeah. No, not I'm not big on the spiciness. Oh, did you know you want to know a fun fact about spicy. Did you know that there's no evolutionary explanation for why humans like spicy like it literally causes us pain, but there's no reason for why we would eat it.

Melanie Avalon:
I find this fascinating. What? Yeah. So like everything out like bitter. Okay. So like when we eat bitter, it's like, oh, it's like, it's like signaling that it's a plant, anti nutrient against the past.

Melanie Avalon:
And like it helps us with all of that, like spicy. There's no, it's literally pain. And there's no reason that we would be doing it. Humans are the only people that willingly eat spicy animals do not animals will go eat like bitter plants because they know it's good for them.

Melanie Avalon:
And medicinally, spicy. Nope. Just humans.

Barry Conrad:
That's really interesting actually that's that's fascinating how did you like how do you find that out that's crazy.

Melanie Avalon:
I don't know. I'm like a, just a collection of family.

Barry Conrad:
Fun facts. Because, listen, I was born in South Africa and- Is spicy big there? Yes, spice and curries and things like that. My palate is just very diverse, so I can really appreciate spice and hot food, and I love it.

Melanie Avalon:
Okay. So, and you have that, what's it called? Lion? Wait, what, what was it called? Something Nate, Pyrenees. Pyrenees. Yeah.

Barry Conrad:
Maybe this is an Aussie thing, paradise.

Melanie Avalon:
I think it might be. I don't think we have that here.

Barry Conrad:
But can you will you maybe potentially kind of maybe try it.

Melanie Avalon:
I knew you were going to ask that. I knew, I knew that was going to, no.

Barry Conrad:
But what if you just like dip your little pinky into it and go, maybe it's kind of okay.

Melanie Avalon:
Barry is always like, will you maybe try this one thing just once, maybe?

Barry Conrad:
like oysters. Melanie, Ellen doesn't know oysters.

Melanie Avalon:
I will try oysters because oysters fit in my, like, real food animal thing-ness. I don't like spicy though.

Barry Conrad:
Did I ask you about travel? So when you travel, does your, okay, let me give you a scenario to give a context. If you're traveling for family vacation for a week, I know that you like to travel for a day, but just stay there for a week.

Barry Conrad:
And it's like family, you know, you're celebrating maybe a birthday or something like that. You're there for a week. Will you adjust your, not all allowances, but would you change your eating protocol, aka, or your fasting protocol or not?

Barry Conrad:
And why?

Melanie Avalon:
Yes. So, so many thoughts. I think honestly the hardest thing in my intermittent fasting journey has been the social situation of how people think it's weird to make certain dietary choices or certain fasting protocols.

Melanie Avalon:
Like it seems really weird. And the hardest part for me has been knowing what feels good in my body and being okay with that and not feeling bad, like not feeling like I need to change what I'm doing for other people.

Melanie Avalon:
Like that's been really, really hard. So when I travel, which is not like all the time, because as you know, it's not my skillset, but I am much happier with everything if I just eat what I really know that I like.

Melanie Avalon:
And when I go to like parties or things like that, like I know what I like. And if I eat that and drink that, I feel better in my body. And so I it's been a whole journey to like accept that I can do that and not have to feel bad about it.

Melanie Avalon:
Because people really want you to eat the things like they really want you to do. I agree with that. And I actually had a moment recently, which is like this beautiful shining moment. So my mom has kind of been not the most accepting of my dietary choices for a long time.

Melanie Avalon:
So because I first went low carb in 20, I think like 2010. Can you tell me what?

Barry Conrad:
That means what is what is local mean in the context like.

Melanie Avalon:
Oh, so in 2010 is when I found the whole Atkins keto thing. And so I just counted carbs, basically. So I stopped eating sugar and grains and like I was eating a lot of meat and dairy, a lot of dairy as well.

Melanie Avalon:
But I was counting carbs, like counting carbs. And that's when I started that. That was 2010. I started intermittent fasting in 20, probably like 2011 or 12. And then I started 2012, like cutting out processed foods.

Melanie Avalon:
So it's been a long time of going to restaurants with my family and being crazy with what I order. Because even with low carb, I wasn't with low carb, I was not modifying it as much as I do now. But I was eating really low carb and making modifications, like ordering weird things and not eating dessert.

Melanie Avalon:
And my mom was always so like not about she was not about it. And she texted me like week before last, probably. And she said, quote, I have an apology for you. And I was like, Oh, gosh, like what happened?

Melanie Avalon:
I was like, what? And then she was like, she started doing an elimination diet by her doctor's referral. And she's realizing how much she reacts to foods and how it makes her feel. And she was like, I'm doing an elimination diet.

Melanie Avalon:
I'm realizing that I can't tolerate these foods. And I'm so sorry that I gave you so much grief for so long about ordering certain things at certain restaurants. And now she's like all about it. And for like a week straight, I got a text like every day being like, I'm so sorry that I so point being of all of that is there's this crazy because food is really social.

Melanie Avalon:
And I do love like enjoying meals with people and social context and enjoying it. And but to answer your question about what I modify for situations like with family and traveling.

Barry Conrad:
Let me give you an actual hold on. Let me give you a thing. If Barry Conray came over there, I was like, no, we're going out to eat. You know, we're doing this, we're doing that. Would you if I ordered, I'd probably typically ordered mainly sort of the same ballpark of what you'd have for like the appetizers, mains and stuff like that.

Barry Conrad:
But if I ordered like, maybe like a dessert, would you have like a spoon of dessert, of my dessert?

Melanie Avalon:
I would eat what I, because here's the thing, like I would, I get so much joy from, because I, okay, multiple things here, thing one. And there are different types of people, we talked about this earlier, like extremists versus moderationists.

Melanie Avalon:
For me, it's like AA, like having a bite of that sugaryness makes me just, it does not feel, it tastes amazing. And then I am craving and wanting. It's like not an experience that I like having, like it's horrible.

Melanie Avalon:
Like I'd rather just not have it. And I can genuinely, honestly, I know you don't believe me, but you having it, I can like enjoy like you having it and like seeing it and hearing from you how it tastes.

Melanie Avalon:
And then I get the best of both worlds. Cause I get to enjoy it, like the idea of it without getting that intense craving feeling.

Barry Conrad:
So, you know, it's really weird what in a kind of maybe similar way, like, I often ask people, even if it's like someone that I just met, like, we'll talk, make small talk and stuff. So also, what's for dinner or what's for lunch?

Barry Conrad:
And that's my way of enjoying vicariously. What do you want to know? Like, you're weird. What a widow like they want to know. Same, same. There you go. I get it.

Melanie Avalon:
Oh my gosh, wait, I have a good example for that. Here's the thing, okay, I'm so happy you said that. Okay, so this is my question for like you and the universe. So, you know like food shows or like show all the stuff and like all the things?

Melanie Avalon:
For some reason, if you watch that, but you actually eat the stuff as well, it's like all fine. Like you're allowed to like watch it and like be like, oh, if it looks so good and like fantasize about it and then eat it, like you're okay.

Melanie Avalon:
But if you watch it but don't eat it, now you're like weird. And I don't understand that.

Barry Conrad:
Yeah, you gotta, you gotta eat it.

Melanie Avalon:
Wait, you just like undid everything I just let up to.

Barry Conrad:
No, no, I don't understand what you're saying. Like you can't you can live vicariously through. No, I get it. Because I do the same thing. I'm like, oh, and I always ask people like, Oh, so what's for dinner?

Barry Conrad:
Because I when they describe it, something about them describing the food, I can picture myself doing it. And that's like a bit of a dopamine hit. I'm like, cool, I'm good to go.

Melanie Avalon:
Yeah, like I my hack my hack and this is I've talked about this on the show before so I feel okay about saying it now but those foods are so good and it's they're engineered to make you addicted to them.

Melanie Avalon:
So it makes sense. So my hack is I will like when I'm eating my meal at night, I like my blueberries, which tastes sweet and tastes amazing and are healthy for me. Sometimes I'll like look at other foods that are like that I actually wouldn't eat.

Melanie Avalon:
And it's like I get to experience them vicariously while still eating amazing food. And everybody wins because I'm not going to actually eat it because it makes me it's not good for me and it makes me feel like not good.

Barry Conrad:
I will say, Mel, like one thing that I have changed, maybe the past, I think I've mentioned this to you before, like the past couple months, I did cut back a lot more my ultra processed food. And what I mean by that is a lot of food that we buy is processed in some way.

Barry Conrad:
But ultra, I mean, like your cheetos and your chocolates and stuff like that, you know, I mean, like, and just that alone has made such a difference. I've still been able to drink as much because I like to drink while I cook like a much on a mess up, sound like alcoholic, like I cook and drink at the same time I enjoy it, you know, I can drink a lot more wine, I can eat a lot more food, but it's real foods,

Barry Conrad:
whole foods. And I can digest a lot more and get the same results somehow without having the ultra process. So can you speak to that a bit more? Like, why is that? How does that work? Because I can eat a lot of more chicken or more rice or fruit or whatnot, and wine, and just cutting out a couple more blocks of chocolate or whatever, it makes a difference, right?

Melanie Avalon:
Yeah, no, there is magic. There's such magic to eating complete whole real foods, which is kind of like the theme of this episode. But like when they're in their whole foods form, it takes a lot more energy to digest them.

Melanie Avalon:
It's not like instant, just energy going straight into you from the from the processed foods. And the amazing thing is once you actually do clean up your palate, and people don't believe this, and I wouldn't have believed it because I used to eat all the foods.

Melanie Avalon:
But you start craving natural real foods in their whole form. And that's what's hard to communicate to some people. But I am so satisfied eating my stuff I eat, which is like plain meat, plain chicken, plain scallops, cucumbers, blueberries.

Melanie Avalon:
And it tastes amazing. Like I get the best of both worlds. And I mean, we could do a whole tangent. But actually, so there's this guy named Mark Shatsker who wrote books called The Dorito Effect and The End of Craving.

Melanie Avalon:
I've had him on the Melanie Avalon Biohive podcast. Okay, so his theory, which is mind blowing, is that this is like a whole, whole tangent. But his theory is that when so like foods have these added vitamins, and they have added like sweeteners that are non caloric.

Melanie Avalon:
And it sends a lot of confusing messages to our body because on the calorie side of things, like it tastes super sweet, but it has like artificial sweeteners. So it's like not exactly what we think. And then the vitamins, we get vitamins, but not in the context of the way they would have been naturally.

Melanie Avalon:
And basically, it makes our body just freak out and like shut down, like metabolism wise. And there's been studies on this. So I mean, he goes to the extreme like saying that if you have a sugar free processed food with less calories, you'll gain weight because your body shuts down because it's getting mixed messages about it.

Melanie Avalon:
But I think there's something really big to eating whole foods in their natural form with the vitamins that they have the nutrients that they have and like communicating the right signals and feeling satiated compared to these processed foods, which are all over the place and oftentimes, oftentimes high energy with no nutrients on the flip side of things.

Melanie Avalon:
It's just it's not good. Like it basically just puts our body into a constant fat storing mode and possibly a state of uncertainty, which is what his theory is.

Barry Conrad:
Can I ask you, so I know things are a little bit different over there, but define because it's kind of a slippery slope to say, processed food, because a lot of food, even if it is healthy, is in some way, I don't know, handled or processed.

Barry Conrad:
Yeah, so what is the gauge for that? Because you can't really get a pure straight out of the soil, you know, something to eat.

Melanie Avalon:
Well, there is the whole Nova classification, do you know about that?

Barry Conrad:
No, tell me, because I feel like people do the best they can do in terms of what they know. So they might go, I'll avoid the Doritos isle. I'll go to the veggies section. But even some of those veggies are sprayed with things or handled before they get to the grocery store.

Barry Conrad:
But people thinking they're doing the right thing. So do you know what I'm saying? I do. It's not completely pure, but it's the best of what you can get, I guess.

Melanie Avalon:
So I'll give you the technical legal answer, and then my thoughts. So the Nova classification system, it came out in 2018. And they basically put food into four groups. So group one was unprocessed or minimally processed foods.

Melanie Avalon:
So that's basically what we think of with unprocessed. So fresh, dry or frozen vegetables or fruit, grains, legumes, meat, fish, eggs, nuts, seeds, so like food in its real form. You can remove unedible parts like the skin or something, but it's like you're not actually changing the food.

Melanie Avalon:
And there's group two, which is processed culinary ingredients. So that's plant oils, animal fats, sugar, honey, salt. You're basically refining, grinding, milling or drying. Then there's group three, which is processed foods.

Melanie Avalon:
So that's with the canned pickled vegetables, meat, fish, fruit, bread, cheese. You're basically taking the group one, so like the real foods, and then you're adding in group two, which is the processed foods.

Melanie Avalon:
So like adding sugar in the process or in the pickling process, the smoking process, the curing process. And there's group four, which is ultra processed foods. And that's the worst. And it's basically a series of, it's where you're extracting, you're chemically modifying.

Melanie Avalon:
It's what we think of with like fast food and all the things. So it's things like packaged snacks, reconstituted meat, prepackaged frozen dishes, all the things. And what was exciting about this was that it actually gave definitions to this idea of processing, and then they were able to track how it affected health, if it was like which group it was in.

Melanie Avalon:
That's like a technical answer for more like my thoughts. I really feel like it's kind of more common knowledge. Like is this food that you're eating a food in its real form that we would have eaten hundreds of years ago?

Melanie Avalon:
Because what was your question about people being confused about it?

Barry Conrad:
Yeah, so I mean, I'm projecting, but maybe the average person going to the grocery store might go, okay, this is day one of me being healthy. My first thought is just avoiding the Cheetos and chocolate candy aisle.

Barry Conrad:
And then we just go to like where I can see vegetables maybe, and maybe I'll grab some of that. And then maybe I'll grab maybe a package of ground beef, and then maybe I'll grab a pack like some potatoes and some rice.

Barry Conrad:
But even those things that seem healthy, maybe are treated before they get to the grocery store in some way. Yeah, but that's the best I know.

Melanie Avalon:
here's my suggestion. So and yes, and I think any step you take, especially if you've lived in the, the current world of food and processed foods, like any step towards not that is amazing. So thumbs up.

Melanie Avalon:
I think some, I think there's some good tenants people can follow to break out of that, which is one at the grocery store, if you shop around the perimeter, because most of the fresh stuff, so like the meat, the fruit, the veggies, they aren't in the center aisles.

Melanie Avalon:
They're in the perimeter. So don't go into the aisles unless required. You might go into the aisles for if you want some like olive oil or coconut oil or spices, but in general shopping around the perimeter.

Melanie Avalon:
And then honestly food shouldn't need an ingredient list. Like it shouldn't have a label. Like it should just be the food and even things that do have labels. So like talking about the spices, if you go look at the spices, like turmeric and ginger, like it should just be turmeric and ginger.

Melanie Avalon:
There shouldn't be like all this other crazy stuff added. I think having that paradigm can really help with making choices, but I do think it's like it's a stepping stone and it requires a lot of education because like you just said, it's crazy.

Melanie Avalon:
Like you can buy something and you think it's not processed and like the original, but it has all this stuff added. That happens a lot with especially with like seafood and happens a lot with like seafood and things.

Melanie Avalon:
We're like chicken even. Like a rotisserie chicken. Like okay, like I'm being good. I'm buying a rotisserie chicken. Like it's chicken. But then you look at the ingredients and it has like corn syrup and sugars and flavors and sweeteners and it's like what?

Melanie Avalon:
That's not like just chicken. So I just think education is the key and having eyes wide open. But anybody can look at an ingredient label.

Barry Conrad:
But then can I ask you again, coming back to the example of, for example, like if when I buy, you know, if I'm feeling like I deserve this treat, I want this treat, and I'm buying chocolate, and maybe a bag of chips, and I'll have that maybe one day a week, but then, you know, I'm still pretty, I'm fine still, obviously, the next day, I know, based on experience, like the next day, I'll probably feel a bit bloated or feel a bit,

Barry Conrad:
there's waterway because of that extra salt and stuff like that, it's fine. I don't freak out. But to the average person, they might think, Oh, my gosh, I've gained all this fat, it's not possible to gain a pound or a kg of fat overnight.

Barry Conrad:
But people freak out because they get on the scale the next morning and go, I'm fat now, or I've gained weight. It's like, well, you got to understand how food works, right?

Melanie Avalon:
Yeah, there's so many thoughts there. One is yes, you can't so if you have like one meal or snack or treat off and the next day you gained X amount of pounds like you didn't

Barry Conrad:
I call it trinkets, trinkets.

Melanie Avalon:
I know, that's like an Australian world, a trinket.

Barry Conrad:
That's actually not, it's a mini thing. People are like, Trinkets, what the heck?

Melanie Avalon:
Is it not Australian? No. Trinket. If you have a trinket.

Barry Conrad:
I call tricas like chocolate chips things like all the kind of like, you know, things that I wouldn't normally have if I'm trying to prepare for like a shoe or something, you know, you know, I'm talking about like, what does that think the ferry?

Barry Conrad:
What is the thing you like the

Melanie Avalon:
Like a snack? Like a treat. A treat. What's that cake that you like? Confetti.

Barry Conrad:
Yes, that's what a trinket is to me. That's a trinket.

Melanie Avalon:
Funfetti. Funfetti is not trinket, it's an experience that we'll never come back from.

Barry Conrad:
You need to introduce me to it and you can watch me have it.

Melanie Avalon:
Yes, I'm down. Yep. Yes, yes. And the gluten free one that tastes basically the same. I think it's really important for people to understand their mindset and the relationship with all of this, because some people can have the trinkets and like feel great and, or have the trinkets and maybe not feel great, but it doesn't create a downward spiral because I think that's the problem with a lot of people.

Melanie Avalon:
And either way, say you're doing like really great and you're like fasting and doing all the things and you have like a cheat meal or whatever, everything is okay. That's my message. Like everything is okay.

Melanie Avalon:
And I just don't want people to get into the mindset of everything is ruined and falling off the wagon because that just leads to more like falling off the wagon. And some people, I think you need to know yourself.

Melanie Avalon:
Some people are good having trinkets occasionally. And some people like for me, it's like just not a good thing. So I'd rather not go there. Some people can have them. And either way, like you said, like one, you know, moment is not the ruin of everything.

Melanie Avalon:
I think people just need to know themselves. And I, and last thing, I think they need to have experience what it feels like to eat all natural, whole, real foods. And then they can actually tell the difference of what the different things feel like.

Barry Conrad:
It's just more satiating and speaking like that's funny that you mentioned your mom like my mom Reese as a light has Been talking so much more about oh, wow, like, you know I've been having more protein in my diet.

Barry Conrad:
This is like just changing the way I feel like I feel more full I'm like, I know And so it's the same sort of like aha moment like she's never really Maybe just known about that, you know, like the benefits of that so Knowledge is it's important for people to know that protein is so foundational Like as we age our muscle decreases like I want to say a percentage Every what is every year every decade you tell me about it.

Barry Conrad:
It's a lot. Yeah, so After a certain age so like it's important to be having a lot of protein, you know That's the foundation and then I don't think it's a deal breaker whether it's fat or carbs, but it depends on how you feel Everyone will be different.

Barry Conrad:
So some people can do more fat somebody could do more carbs, but It's just such a game changer and you feel more full if you're just having carbs all the time You're gonna crave everything you're gonna eat all day.

Barry Conrad:
I promise you

Melanie Avalon:
It's so true. There's so much magic to when you focus on protein for satiation, hunger, and then like you were saying body composition, all the things, and you can have all of it in a short amount of time and build muscle.

Barry Conrad:
despite what people may believe.

Melanie Avalon:
I know. I know. Oh my goodness. So many things. Well, this was amazing. We didn't even talk about wine.

Barry Conrad:
Yeah, well, give me like a real quick succinct elevator pitch about wine, because I've heard Melanie in my in my life, people have been coming out saying, I've read these new studies saying alcohol is all bad now, like even two glasses a week is really bad.

Barry Conrad:
So what's your take on that? Red carpet answer, you have to answer it really quickly.

Melanie Avalon:
Oh my gosh, so many things. Well, I did recently have an article published about this in Fox.

Barry Conrad:
I saw that. Congratulations.

Melanie Avalon:
Thank you. Thank you. My thoughts are that the if we look at the studies, the curve is consistently a J shaped curve. So people who drink moderately, minimally to moderately seem to have the best health effects compared to people who don't drink at all or people who drink to excess.

Melanie Avalon:
And if we look at populations like the longest lived studies ever, the longest lived populations, they're all drinking wine. I think there are a lot of health benefits to wine when it comes to the polyphenols and all of that when it comes to drinking.

Melanie Avalon:
So the studies that keep coming out about it saying that it's, you know, horrible and no drinking is better than drinking at all, I just I feel like we look at reality. That's not what we see when we look at people drinking and we look at the mechanisms of what certain things in alcohol might be doing.

Melanie Avalon:
Honestly, I think people should do like you need to know yourself. So you need to know how what works for you in your life. It's kind of like the things with the the processed foods and all the things like are you a moderationist?

Melanie Avalon:
Are you extremist? Like who are you? So knowing yourself. And then I think the the type of drink that you're drinking is super important. So I've talked about this a lot. But I think one of the main problems with all these studies is that they're lumping together all alcohol into one category and they're not accounting for what type of alcohol, especially with wine.

Melanie Avalon:
This is why I talk about dry brown wines all the time. There's a big difference between conventional wine, which can be high, high sugar, high alcohol, high pesticides, high toxins. That's way different from having dry farmed, lower alcohol, low sugar wine from Europe.

Melanie Avalon:
That's why I only drink that type of wine. And you will feel massively different if you drink that type of wine compared to conventional wine, which can actually have up to I think over 70 additives are approved for wine in the US, which is crazy.

Melanie Avalon:
Crazy. Fun fact, if you're drinking wine at a bar or something like cheap wine and your teeth turn purple, I used to think that that was the wine turning my teeth purple. It's not the wine. It's because there's a dye in the US called mega purple.

Melanie Avalon:
And they put it in the wine. And it's like a purple dye. That's the type of stuff. Yeah. Because I think that was like wine. Like, oh, I can't drink wine because it'll turn my teeth red. No, you can drink wine.

Melanie Avalon:
Just don't drink conventional wine that's mega purple added.

Barry Conrad:
But why they're adding, I don't understand why you would add die to one.

Melanie Avalon:
Consistency, because so much of the wine in the US, it's all owned by a few key wine producers that own everybody. And they want to mass produce wine and make it all the same. And they do that through dyes and additives, so then they can just turn it out like a factory.

Barry Conrad:
A quick fire answer from you like white and red wine, if someone prefers white wine, is that still beneficial in some way or not at all? Because a lot of studies come out like red wine is like great.

Barry Conrad:
So the layperson, give them like a little something.

Melanie Avalon:
No, that's a good question. I do think a lot of the health benefits from wine come from the polyphenols that are in red wine. And they're higher in red wine because when you make wine, the reason wine is red or white is because whether or not it's macerated and exposed to the skins and the fermentation process.

Melanie Avalon:
And so you get a lot more of that in red wine compared to white wine. There's been a lot of studies looking at red versus white wine. I do think... So I think this is just my opinion, but I do think that minimal to moderate drinking probably has health benefits for a myriad of reasons.

Melanie Avalon:
I think we'll get way more health benefits from red wine. That said, I am an advocate, like I said, of dry farmed wine. By the way, speaking of quick tangent, if you'd like to get the wines that I drink every single night that actually check for this.

Melanie Avalon:
So they check that it's low alcohol, low sugar, organic, free of pesticides, free of mold. They don't even sell or give US wines because they don't meet their standards. It's called dry farmed wines.

Melanie Avalon:
You can go to dryfarmedwines.com slash Melanie Avalon and get a bottle for a penny. That's why I drink every single night. I love them. It's amazing. They have white and red. But back to your question, I do think there are more health benefits to red wine.

Melanie Avalon:
I also think in a healthy lifestyle, if white wine is your wine of choice and you're drinking the wines that I talked about, that you can probably get health benefits from it. I know it's like super controversial.

Melanie Avalon:
Oh, wait, one more thing. I'm interviewing next week, the creators of The Mind Diet, which is kind of like the official diet for Alzheimer's.

Barry Conrad:
Oh, wow.

Melanie Avalon:
Yeah, so they've done a lot of research and they've been around for quite a while and it's like the diet like they've done that they've done the most scientific research on the best diet for Alzheimer's and they include in their diet because

Barry Conrad:
Where in Panama is like, I'll have like a Pinot Noir and like a Tempranillo, but I'll also do at the moment drink a lot of Pinot Grigio. A lot Pinot Grigio. And it doesn't seem to have seemingly any effect on my body.

Barry Conrad:
I don't understand that though.

Melanie Avalon:
I just think there's this whole misconception, all of alcohol is lumped together in one thing, and it's not taking into account the type, like wine specifically, and the types of wine. But I do think there's a lot of fear mongering around alcohol.

Melanie Avalon:
And I understand why completely, 100%. But yeah, I do feel strongly that you can definitely have, you know, alcohol in your diet and have the health benefits.

Barry Conrad:
I think what you're saying, it's about knowing yourself. It's really important to know what you respond to, well or not.

Melanie Avalon:
Yes, completely. And that's kind of what it is with honestly, with everything, like we're talking about in the beginning, the fasting, the eating, all the things.

Barry Conrad:
Even with fasting, I always I tell people like, oh, this is what I do. But, you know, like, I know it's not for everyone. It's just you got to do what's best for you because you immediately just want to derail that whole thing.

Barry Conrad:
Well, you're trying to make me do what you do. I'm like, no, I'm just saying this works for me, but you should do what works for you.

Melanie Avalon:
Exactly, I cannot read more like find what works for you and my goal with these shows just share what I'm learning until people can make your own decisions and find what works for them what.

Barry Conrad:
What's the Alzheimer, the diet? That's wild. There's a diet for that.

Melanie Avalon:
Yeah, I'm so excited to interview them. Like I said, they have the most scientific studies on diet for preventing cognitive decline.

Barry Conrad:
I think I've mostly read one.

Melanie Avalon:
I drink mostly red. I drink both though. Okay, so they do five ounces of dry red wine. I'll do any varietal. It just needs to be what I said, like dry, low alcohol, low sugar, organic, all the things.

Barry Conrad:
Okay, what can't tell me what low alcohol means for you per bottle? Like is it 12% is it 11% is it like a 8%?

Melanie Avalon:
Dry Farm wines, all of Dry Farm wines is 12.5% or less. And you can get on their extra low ABV subscription, which I love. And that's what I am on. Oh, by the way, join Dry Farm wines now. When you sign up, it's random, like you click what you want, and they send random varietals.

Melanie Avalon:
So you can do that to start. You can also email them and you can tell them exactly what you like, and they'll help cultivate exactly what you want. And you can request extra low alcohol wines. So all of their extra low alcohol are 11.5% or less.

Melanie Avalon:
But yeah, 12.5% or less is what they consider low alcohol. When I'm at restaurants, because it's hard to find that, when I'm at restaurants, I try to go for 13% or less, max 13.5%, but not above that.

Barry Conrad:
Do you know what's interesting over here in Australia? Like our, our baseline over here is 12% per bottle, but it's a 750 mils bottle.

Melanie Avalon:
Well, that doesn't matter because it's like it's the percent of the alcohol. But oh, wow, I should come to Australia. I should come to Australia. You can come to Atlanta.

Barry Conrad:
Please come here because we need you, we don't have anything like you here.

Melanie Avalon:
I know. When you come here, I'll stock you up. I'll give you all the things and you can take them back.

Barry Conrad:
Yeah, they need to ship to Australia. I wonder why they don't ship internationally. Maybe it's something to do with cost.

Melanie Avalon:
Yeah, I don't know. But dryfromwines.com slash Melanie Avalon, use the coupon code Melanie Avalon, it will get you a free bottle for a penny. I love it. So yeah. Oh, wait, one last question about that.

Melanie Avalon:
Do you normally... So I always break my fast with wine. Do you normally have wine to break your fast or with your food? Like when do you have wine or wine alcohol?

Barry Conrad:
I would actually like to ask you this question, because I've been listening to, I'm not going to say who, but just certain podcasts and stuff, and they all say, particularly if you're training and things like that, resistance training for context, that you should, your first quote unquote meal should be a certain amount of grams of protein.

Barry Conrad:
But at times, like I'll often crack open a bottle of wine while I cook my first meal. So is there a difference in terms of the protein hitting your system if you have the wine first, or the protein first after a fasted steak?

Barry Conrad:
Because I do both. Sometimes I just do the protein first, sometimes the wine first, or whiskey.

Melanie Avalon:
Do you know that the body prioritizes breaking down alcohol before anything else so if you have wine in your system your body is gonna be like focused on that but the food is still there the protein still there so you are going to break it down eventually and i actually don't like drinking wine or alcohol with meals for this reason because i feel like it slows down.

Melanie Avalon:
It like slows down processing carbs and protein and fat so that's why i actually like going out drinking and then coming back and eating but that's just me.

Barry Conrad:
Is there a time limit then? For example, let me give you a scenario. If you're going out tonight and you're going out and having a drink, is there a certain amount of time that you go, I know if I wait this long, this will be optimum for me to eat at this other time to break down the protein.

Melanie Avalon:
I think it depends on a lot of things. It depends on what you drink. It depends on some people are faster, alcohol, metabolizers. It's like caffeine. So some people process it faster than others. Like for me, apparently I process alcohol really good.

Melanie Avalon:
Caffeine, not so much. So I think it's really individual. I don't have a blanket answer. I honestly don't know the answer. I don't know that there's enough studies on that. I just know for me... That'd be an interesting study though, right?

Melanie Avalon:
Oh, it would be. Yeah. That's like my type of study. Like if I had like unlimited funds and I could do a study, I would do something like that for sure.

Barry Conrad:
Because I often do that, like I'll open it with a glass of wine or whiskey or a whiskey sour while I'm cooking my protein-heavy meal.

Melanie Avalon:
I love that. And for me, like, I feel like it puts you into a, because we know for eating, you need to be in the parasympathetic, like, relaxed, digested and rest state.

Barry Conrad:
What does that mean, Melanie, for the layperson, if they hear what his person thinks?

Melanie Avalon:
like your nervous system has two main forms that can be in, which is the sympathetic. So that's like fight or flight, like, like adrenaline doing things. And then there's the parasympathetic, which is the like resting and digesting.

Melanie Avalon:
And so you oscillate between the two on different spectrum levels. And so I find for me that having a glass of wine with a meal helps ease you into that. I find it helps with digestion.

Barry Conrad:
It's so interesting, because a lot of people just eat or drink how they want, but it's just interesting how different things affect different results. It's crazy.

Melanie Avalon:
Yeah, takeaways from this episode. Okay, here are my takeaways. Let me know if you would add something. Find what works for you. Protein is really important. And also, it's okay if you eat it all at once in a massive meal.

Melanie Avalon:
You can still maintain or even gain muscle. Process foods. Try not to eat them. Try to eat the most natural form that you can. Do what works for you and don't be upset by other people judging you on your dietary choices.

Melanie Avalon:
Anything else?

Barry Conrad:
And I would say as well, it's really picky, but more like I would say ultra processed food. Because I feel like a lot of food, even if they're healthy, they can be kind of processed. Don't worry about that.

Barry Conrad:
But I feel like the ultra processed stuff, just avoid like what Melanie said before, avoid the center aisles in the grocery store. You know, like you'll be you'll be fine. You don't need cereal in your life.

Barry Conrad:
It's okay. You don't need it.

Melanie Avalon:
Live your life, eat real foods, look at labels.

Barry Conrad:
So do you, you know, if that's where you're at, like you got to be conscious for a patient because we're taught a certain thing and everyone learns or moves forward in different ways.

Melanie Avalon:
Not only are we taught it, but we've grown up in a culture that has been scientifically engineered to make us crave it and want it more. So be kind to yourself. The deck is stacked against you and you can see the light and then make choices and go at your own pace.

Barry Conrad:
And I will definitely say this, it sounds like such a cliche thing to say, but food is so important. People like what we put in our bodies really does matter. It'll balance for longevity, for our present, for our future.

Barry Conrad:
Like it's, it's everything. Like just be mindful. You know, there are other choices that can taste equally amazing. That don't have to be what you've always known before.

Melanie Avalon:
like you will enjoy it at these dinners. I really do enjoy what I'm eating, even if I don't eat dessert, Barry.

Barry Conrad:
But I will have that cake. What is it?

Melanie Avalon:
I'm having a holding you to it when is this is so fun you have to come back in the future and update us.

Barry Conrad:
And in person, we'll have to do an IRL episode. I mentioned that.

Melanie Avalon:
I've actually, I've only done one in-person interview ever.

Barry Conrad:
Okay, Melanie, when I come over there, we have to do it like when I come over there, it's a winner than if we have to do an IRL because I'll be there.

Melanie Avalon:
Do we have to, Flo?

Barry Conrad:
We have to and you know what though part of the episode was the cake will be there and I will do it.

Melanie Avalon:
Like in person? Of course. Can we just like do that and then we'll talk about it later?

Barry Conrad:
Why don't you go like, why don't you like video? Like, what does your deal with that? Cause you're an actress.

Melanie Avalon:
I know. I don't like seeing myself. Oh, I guess. I like audio. Can't we just like also do the interview later because.

Barry Conrad:
Yeah, we can. We don't have to do it.

Melanie Avalon:
If we're like doing an interview while having the experience, I feel like that's like too much taken and like I'm a control freak and like trying, you know, we should like have the experience and then we'll do an interview.

Barry Conrad:
have the experience and then we can debrief. Yeah, that makes sense.

Melanie Avalon:
Yeah. Awesome. Okay. Well, this has been absolutely amazing. Friends, listeners, these show notes will be at ifpodcast.com. So you can read a full transcript there as well as links to everything that we talked about.

Melanie Avalon:
You can follow us on Instagram at ifpodcast. I am Melanie Avalon Berry. Are you Berry Conrad on Instagram?

Barry Conrad:
berry underscore conrad

Melanie Avalon:
Barry Underscore, Conrad.

Barry Conrad:
But if you just type in Barry, you'll actually find me and we'll just come up.

Melanie Avalon:
Oh, yeah, just Barry. And he's like the first one that pops up. So definitely follow him as well. And this has been so amazing. Thank you for this conversation. And hopefully we can talk again in the future.

Barry Conrad:
Thank you so much for having me and I hope you all enjoy it.

Melanie Avalon:
All right. Have a good day in Australia. It's like midnight here. It's like what, noon?

Barry Conrad:
Thanks for making the time. It's like 2.17 here. PM in the afternoon. It's crazy. Have a good day. Have a good night.

Melanie Avalon:
Good time, mate. 

Melanie Avalon:
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by Podcast Doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Vanessa: ketogenicgirl.com

Original theme composed by Leland Cox and recomposed by Steve Saunders.

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts - it helps more than you know! 

 

 

Nov 17

Episode 396: Coffee, Low Cholesterol, Histamine Intolerance, Fasted Workouts, Flushing, Inflammation, Red Light Therapy, And More!

Intermittent Fasting

Welcome to Episode 396 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Vanessa Spina, author of Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

iHERB: iHerb is your easy, affordable, one-stop shop for wellness products across supplements, sports nutrition, groceries, beauty, baby, pets, and more! With over 50,000 products available, iHerb uses NO third party sellers, and ensures that what’s inside every bottle is tested and verified for quality. Plus, their climate-controlled shipping keeps everything fresh! Get 22% off your first order with code IFPODCAST at iherb.com/shop/IFPODCAST. Existing customers get 15% off!

PERSONAL DEVELOPMENT: Transform your relationships through changing your attachment style: the most powerful and influential driving force behind your beliefs and behaviors and the ultimate predictor of success in your relationships! The Personal Development School’s All-Access Pass is an immersive platform that offers tailor-made on-demand courses and programs, daily live webinars and Q&A sessions (with founder and author Thais Gibson herself), study groups, and much more that help you heal your attachment style! Get 50% off a Monthly Membership of the All-Access Pass with code IFPODCAST at ifpodcast.com/development.

LMNT: For fasting or low-carb diets electrolytes are key for relieving hunger, cramps, headaches, tiredness, and dizziness. With no sugar, artificial ingredients, coloring, and only 2 grams of carbs per packet, try LMNT for complete and total hydration. Go to drinklmnt.com/ifpodcast to get a free sample pack with any purchase!

To submit your own questions, email questions@ifpodcast.com, or submit your questions here!! 

SHOW NOTES

iHERB: Get 22% off your first order with code IFPODCAST at iherb.com/shop/IFPODCAST. Existing customers get 15% off!

PERSONAL DEVELOPMENT: Get 50% off a Monthly Membership of the All-Access Pass with code IFPODCAST at ifpodcast.com/development.

LMNT: Go to drinklmnt.com/ifpodcast to get a free sample pack with any purchase! Learn all about electrolytes in Episode 237 - our interview with Robb Rolf!

Listener Q&A: Nicole - Hi ladies! I have a question regarding facial flushing during fasting.

The Melanie Avalon Biohacking Podcast Episode #62 - Dr. Becky Campbell

SEED: Go to seed.com/ifpodcast and use code 25IFPODCAST to get 25% off your first month of DS-01®!

FOOD SENSE GUIDE: Get Melanie's app to tackle your food sensitivities! Food Sense includes a searchable catalog of 300+ foods, revealing their gluten, fodmap, lectin, histamine, amine, glutamate, oxalate, salicylate, sulfite, and thiol status. Food Sense also includes compound overviews, reactions to look for, lists of foods high and low in them, the ability to create your own personal lists, and more!

Listener Q&A: Heather - Trying to get back to fasting but I do a CrossFit type gym at 6am.. tried not to eat before once and got dizzy after... any tips?

Listener Q&A: Lisa - Inflammation & Joovv

The Melanie Avalon Biohacking Podcast Episode #224 - Forrest Smith (Kineon Labs)

Listener Q&A: Jodi - I appreciate your input on how to start with such a crazy life with work and kids.

Listener Q&A: Nicole - What are your biggest regrets?

Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.

TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.) 

Melanie Avalon:
Welcome to Episode 396 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of "What, When, Wine" and creator of the supplement line AvalonX. And I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of "Keto Essentials" and creator of the Tone Breath Ketone Analyzer and Tone Lux Red Light Therapy Panels. For more on us, check out ifpodcast.com, melanieavalon.com, and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Melanie Avalon:
Hi, everybody, and welcome. This is episode number 396 of the Intermittent Fasting Podcast. I'm Melanie Avalon, and I'm here with Vanessa Spina. Hi, everyone. Vanessa, can I ask you some questions? Sure. You drink coffee, right? Yes. I'm curious, in your coffee drinking habits, what is most important to you for the coffee? Is it the flavor, the health benefits, the antioxidants, the mold content?

Vanessa Spina:
I would say flavor and low mold content. Yeah.

Melanie Avalon:
That's what you.

Vanessa Spina:
Cause we, yeah, we have an espresso machine, so like we grind everything fresh. I keep everything sealed. I have a vacuum sealer that I use specifically for my coffee beans. So when I open it and fill the hopper, then I can reseal the bag and there's zero air in there and it keeps them super fresh. So I think that and the, we grind it on the spot and the flavor is really important. So I usually get, is it a hundred percent Arabica? I usually try to get that and yeah, and low mold content, I think is the most important thing for me.

Melanie Avalon:
I'm having an epiphany. Is that little hole on the bag of coffee beans so that you can vacuum seal it back?

Vanessa Spina:
Maybe, maybe there's some machines that work like that. I have like a vacuum sealer that I just take bags and I make my own seal and then I fill it with whatever and then I vacuum seal it after. I got it first when I was doing carnivore because, you know, we would get like these huge stakes divided up and then I would put it in there and seal each one individually or sometimes I would make like smoked brisket or something and then just seal it in there and it lasts forever and the fridge so you don't have to freeze it but then if you vacuum seal it and freeze it then it lasts like literally forever so yeah I got it then but now I use it to keep everything fresh and it's amazing for coffee beans so yeah those are I mean I think extra nutrients would be probably bonus.

Melanie Avalon:
Okay i'm pulling people in my coffee development adventures i had a vacuum sealer i was. Worried about the plastic like ceiling things in plastic but then i realized. Like when i order these frozen things are already in plastic just no easy answer with plastics why can i see a link glass.

Vanessa Spina:
Develop that. Yeah, something is coming, I'm sure.

Melanie Avalon:
Yeah, so how are things in your world? Thank you for the the input. I'm as I gather data

Vanessa Spina:
course. Yeah, things are amazing. I was just at the playground a few hours ago with Luca and I was doing this tandem zip line with him. I posted a video of it on my Instagram, but it's this new thing that we've been doing. There's a zip line at his playground. They have them at a lot of the playgrounds here and he usually goes by himself. And then one day I saw this other mom doing it and I was like, wow, that's crazy. She's doing the zip line with her we tried it and it was so much fun. So I get on it on the zip line and then he gets on on top of me and then we launch off together and we like stare into each other's eyes like screaming. So funny.

Melanie Avalon:
Oh my goodness. Is it on? I love Ziplines or I love them when I was little. Is it on like a hill or anything? Or is it over a height?

Vanessa Spina:
a little bit. It's on a slope and it's just, you know, like it's like a big tire. It's got like a bunch of tires that like break it and stuff. It's pretty well made. Yeah, it's just so much fun. So we were doing that this morning. My husband came down with my mother-in-law while we were doing him and they were laughing and they took a video of us doing it. So I put it on my Instagram. Yeah, it's just a typical day for me now. It's like a zip lining in the morning and then working in the afternoon and evening. I just feel really blessed that I have the energy to keep up with my boys because they're very energetic and do fun things like that with them. It's awesome. How are things with you?

Melanie Avalon:
I'm watching your video right now. Oh my goodness. That looks so fun. Oh, this is so fun. Oh, and it looks so European

Vanessa Spina:
the backdrop of the architecture.

Melanie Avalon:
Yeah, I'm getting flashbacks because we used to always go to Germany growing up and we'd do stuff like that and we do like there were so many seesaws in Europe and my sister and brother and I would just have a blast. Like you'd have to like load up the tire on one side with rocks.

Vanessa Spina:
It's so much fun!

Melanie Avalon:
Yeah, I think those don't fly today in the U.S.

Vanessa Spina:
Yeah, I was going to say I was talking to actually, yeah, Dr. Grant Tinsley last week about it because he has kids. And I was like, yeah, we were doing the zipline this morning because it's also ziplining that morning. And he was like, huh? And I was like, oh, you probably don't have those at your playgrounds. There's a lot more risky things here, I think.

Melanie Avalon:
I remember even when I was in elementary school at the playground, part of the playground was off limits and this was when I was like a little kid, so it's probably all off limits now. Good times, good times. I remember I had a friend that had a zip, she had like a massive, I don't even remember who it was. I just remember going there and that their backyard, they had a massive sloped backyard and they had a massive zip line. They went from the top to the bottom like long, fast and I was like, this is like having a roller coaster in your backyard. This is cool. Oh, I love that. Yeah. So that is awesome. That's awesome. Yeah. What's new with you? I don't know. I had a really good interview yesterday. Do you know Dr. Jack Wolfson, the paleocardiologist? No. He's yeah, the paleocardiologist, but it was a really fun conversation because he's literally the thing I'm probably most haunted by. Let me think if that's true. The main things I'm most haunted by in a diet, nutrition wars and opinions are protein intake and longevity, ironically enough because we talk about protein all the time, and lowering Apobee and LDL artificially with statins for longevity as advocated by Peter Atiyah. And so it was a deep, it was funny because it was a deep dive into like cholesterol and LDL and Apobee and he's very anti-statins and he's also very anti-Peter Atiyah, even though he's never listened to any of Peter Atiyah stuff, which so literally half the episode was me like defending Peter Atiyah to him. And I was like, I don't know that this is a productive conversation, but Oh man, so yeah, I find it interesting when people comment on other people's work when they haven't read their work, you know, so where do you fall on the, on that topic?

Vanessa Spina:
The first one, I mean, I have been bringing it up lately on the podcast and how I kind of had it all wrong. And I really thought that, you know, you had to sort of try to balance out all the mTOR, but I learned from Dr. Kurt Escobar, it's really dysregulated mTOR that we want to avoid and not the mTOR from eating protein and doing resistance training. Like that's not the mTOR that has negative impact on longevity. It actually is the opposite. And how there's these relationships that are so complex, like how mTOR even initiates autophagy and everyone thinks it's only AMPK, you know? So I kind of had it all wrong and I feel really excited and empowered to have learned that because I no longer feel like I have to somehow balance out all this mTOR that I'm doing right now because I personally am so focused right now on building as much muscle mass as I can in the years that I can build muscle mass because you get to a point where you're basically just maintaining. And I'm so excited being in this stage of my life. Like I'm lifting heavier and heavier weights, like I'm pushing harder in my workouts, like I'm experimenting with, I mentioned adding in that other protein meal. So I'm now doing three protein meals a day. I'm getting some great results from it. I'm just all about experimentation. So I'm trying this out and I'm going to assess at the end how I'm feeling with it. But I really, really like it. And I just feel like that used to haunt me and now it doesn't, you know? And for years, I was just so focused on like fasting and AMPK and, you know, this is what we need for autophagy. And yet there's so much autophagy that you get from exercise. And you can see it in people. I mean, when they look at the mitochondria of people who are lifelong exercisers, their mitochondria, they retain way more of their mitochondria, much, much, much, much more. And the capacity of those mitochondria is also maintained way more. And you see it in people who work out that they look younger. And I think it comes from metabolic health. And, you know, I was afraid that too much protein and resistant training would age me earlier. What's the word for it? Premature aging, but it's actually the opposite. And I think that's really, yeah, it's something that you saw at me and no longer does. Like I now have a different view of it. And I think there's just a lot of confusion out there on that topic.

Melanie Avalon:
Have you ever measured or do you measure your IGF-1? I have.

Vanessa Spina:
Yeah, I have before I haven't I haven't done a lot of testing lately just because I'm everything with pregnancy throws things off So hmm. Yeah, that's so true sort of waiting until I'm back to baseline back to a baseline

Melanie Avalon:
Yeah, that makes sense. I've only done it like a few times, measured that, but I feel like whenever I did it was really high. But then it's like I'm measuring it, you know, I don't know, probably at a time when it would be high.

Vanessa Spina:
Well, I think that there are going to be tests coming out in the very near future that are going to help us assess our biological age based on mitochondrial function and the quality and function of our mitochondria that are going to be really, really insightful because you're going to be able to actually tell if things that you're doing are working for you, like if supplements that you're taking are making a difference. And I know, yeah, we've sort of been circling around this topic for a while, but I'm really excited for those things that'll help measure and quantify these things more.

Melanie Avalon:
I agree so much. Do you have thoughts on the, like the super low LDL APOB and statins and stuff?

Vanessa Spina:
know, I mean, what is your current opinion on on

Melanie Avalon:
Well, basically the summary is low fat vegan people will say that, you know, you want super low LDL and I need to clarify that LDL is there's like LDL C, which is like all the different LDLs, when there's LDL P, which is Apo B, which is the particularly part that can create CBD issues. But in any case, there's that camp, then there's like the low carb higher fat camp where they're like, oh, LDL can be it's totally fine. If it's really high, as long as you don't have inflammation and you have high HDL, then there's people in between like Peter who says, who's also is pro, you know, a diet that's, I mean, not vegan, like, that's more similar to a diet that I would probably follow. He thinks, I don't know if this is the exact quote, but he thinks for the ultimate longevity, I think your Apo B would need to be below like 30, which is only achievable with pharmaceuticals. So like he's on statins for longevity. And he has a history, I think.

Vanessa Spina:
My opinion, because there is also in the keto space a lot of talk and rhetoric around lean mass hyper responders and that kind of thing, I don't think it's a good thing to have really high cholesterol, even if people are doing keto. So I think if people are running into issues where they have really high cholesterol, I think it could be dangerous even if someone is doing keto. But I prefer to cut back on fat at that point and switch out fats for healthier ones. And I say healthier with trepidation because I don't mean to not eat any saturated fat, but to me that's like, you know, if someone is doing carnivore or something and they're eating a lot of saturated fat and they're adding a lot of butter to things and, you know, just adding a lot of fat to their diet, you know, just sticking to eating the whole foods in their whole food form, like whole eggs, steak, you know, maybe having some leaner cuts of steak, but not adding butter to the steak kind of thing, not adding extra fat to things and even switching out some fats for I think like olive oil. I tend to use mostly in my cooking coconut oil, but I don't use a lot of it. Like I use a spray. I don't like, you know, coat everything in oil, even though I eat low carbs. So I do think that, you know, just like you don't want to have really high circulating blood sugar, I think you don't want to have really high triglycerides or really high cholesterol. But I personally wouldn't go on something like statins for that. I would just try to do it naturally.

Melanie Avalon:
We're pretty similar there with those thoughts. I do find it really interesting. I like interviewing because a lot of the vegan people will say that you can't eat animal protein and have, you know, low cholesterol levels and mine's really low. So I always like interviewing them and being like, I eat pounds. Same. Yeah. I'm like, I eat pounds and pounds of protein and, you know, I have really low levels. So that's not quite accurate.

Vanessa Spina:
Did you tell Gregor that?

Melanie Avalon:
I'm pretty sure I did in my lost episode. Oh, did you ever re-record it? No, we're recording in October again. Okay, awesome. It was nice to have like a breather in between because it's hard to like redo it like right away, you know.

Vanessa Spina:
I would be, yeah, I would want to either do it right away, like the next day or have a breather.

Melanie Avalon:
Yeah. Well, like the next week would be pretty rough. Yeah. Oh, that's so true. Like, yeah, do it like now.

Vanessa Spina:
I feel that way like sometimes and like I'll have I had a guest once that I had been preparing for their interview for weeks you know reading their book really detailed notes and I was so ready on that day and something came up it was definitely something important having to do with their families they couldn't record that day and I was like yeah we need to do this like either tomorrow or in two months because I can't like come back on this.

Melanie Avalon:
It's so true. I'm about to interview. Finally, Dr. Sarah Gottfried. I think we've rescheduled.

Vanessa Spina:
Oh, I love her like multiple times. She bought my keto program. Like when I was first like starting in the keto space, she has my book too. And she showed it to me when I was interviewing her and I almost started crying. She's just so wonderful, not because she bought my stuff. She's just a wonderful human. And yeah, I'm excited for you to interview her.

Melanie Avalon:
I'm really excited because I ran into her at the biohacking conference and she knew who I was. I have interviewed her, but it was years and years ago, so I didn't think she would remember me.

Vanessa Spina:
That's really cool.

Melanie Avalon:
Yeah, I remember I had that moment with the book. It's because I sent it to him, but when I interviewed Rob the first time he had my book on his desk, I literally wanted to like cry.

Vanessa Spina:
Yeah, it means a lot to you as an author.

Melanie Avalon:
It really does. So, okay. Shall we jump into some things for today? Yes, I would love to. All right. Would you like to read the first question from Nicole?

Vanessa Spina:
So our first question comes to us from Nicole, and the subject is flushing. Hi, ladies. I have a question regarding facial flushing during fasting. I'm a long time faster. In the beginning, I did get facial flushing at the end of my fast. I didn't experience it for a while, but it just started up again. I fast about 16 plus hours, usually opening my window around 230. Every day between 12 and two, I get really flushed, and my face and neck get really red. These are not hormonal flashes, as I have experienced those, and they feel totally different. They gradually disappear after a bit. I'm not dehydrated. I haven't changed anything I eat, and I clean fast. These flushes happen way after I've had coffee. I don't take any medication for hours before. Sometimes they are accompanied by a tension headache. I opened my eating window earlier one day and no flush, but to be honest, I hate not fasting. I plan to keep on doing it. Any insight on why this happens? Some info. I'm 45, lower carb, definitely not keto. Recently, a month ago, was on herbals for an infection. The flushes seem to start after that. I would love your thoughts. There are two emojis of someone really hot. They're flushing. Super cute.

Melanie Avalon:
It's the anger emoji and then like the hot emoji. We love emojis, all the emojis all the time. Well, thank you so much, Nicole, for your question. So there are a lot of things that could be going on here. I mean, it could be things like blood sugar or your adrenals. My thought though, the first thing that came to me, and then especially the fact that you were recently on herbals for an infection and that's when it started. It could be a histamine situation, especially since it's something you've experienced in the past. So basically, his histamine is a chemical in our body. It's released during inflammatory responses, during stress. It's high in a lot of foods, it can be released from the gut microbiome. And some people are just like their histamine bucket gets filled up and they get histamine sensitive and they get symptoms from it, like flushing, honestly, like flushing allergy type symptoms. And so the fact that you've had flushing in the past and then didn't, and then it came again after an infection with herbals, I would bet that you're probably sensitive to histamine and changes in your environment, both externally and or inside of your body are creating periods of your life where it's becoming a thing. And the reason I would guess that it goes away when you eat is because your body's inflammatory response immune system, like the majority of our immune system is in our gut. So once you start eating, it's kind of like switching focus a little bit to your food. If you had some sort of change in your gut bacteria during that infection and with herbals, which is highly likely, it could have created a different balance of histamine producing bacteria in your gut that are producing histamine. The effects of it are appearing during your fast. I mean, a way you could figure out if it's histamine, there are a few things you could do. So I actually interviewed Dr. Becky Campbell on my show for, she has like a histamine diet book. So I'll put a link to that in the show notes. You could try, there's a few things you could try. If you wanted to just see if that's literally the reason, I'm not saying to take allergy meds ongoing, but you could take one for a day and see if it, if the flashes don't happen, the flushing, if the flushing doesn't happen, then it's probably histamine because the histamine would be blocking it. So for example, I mean, you could take a Benadryl that would probably knock you out. You could take like a Claritin or a Zyrtec for a day and see what happens. You could also ongoing try a low histamine diet for a bit and kind of clear out some of that histamine from your system that could have a really, really beneficial effect. And also just working on your gut microbiome health in general could be really helpful. So through your food choices, I don't know if you talk about what you eat, but favoring, you know, a whole foods diet. Oh, you said you're low carb, but definitely not keto. Yep. You know, favoring a whole foods diet, a probiotic I really, really love is seed. I'm obsessed with them. They have a lot of science behind their probiotic strains and I've noticed a lot of great effects on my digestion. And there are certain strains that are histamine producing versus not. And I haven't noticed any issues with seed. So if you go to seed.com/Ifpodcast you can use the coupon code to five I have podcasts to get 25% off, but yes, I look at, I really would bet that this is a histamine thing going on. Do you have thoughts? Vanessa? I think you.

Vanessa Spina:
covered that wonderfully, definitely had the same thought. It could be related to the herbs, especially if that's when it started. And that would be the simplest explanation. So it sounds like it could be something that, you know, your body could still be working through, but I wonder if you could talk to that provider who had you on that and see if there's something going on, or if they might have some insight into that, the practitioner who had you on these herbals.

Melanie Avalon:
What's also really interesting is it sounds like she's thinking it was the herbals, but it also could have been the infection. Like, cause that would have all been at the same time. So, you know, it could have been the infection that caused this change. I really would bet something happened though, with your gut microbiome that is having residual effects from here. And like I said, the fact that you've had this in the past before says to me that you're probably just sensitive to histamine changes again, it might not be histamine, but that's what I put my, my, my money on and oh, a resource. You can get my app food sense guide. It's a comprehensive catalog of over 300 foods for 11 different compounds in food that people often react to and have, you know, reactions to. So things like FODMAPs and lectins and gluten oxalates, it includes histamine. So definitely download that. There's a free trial it's at MelanieAvalon.com/foodsenseguide. Oh, and I think it's like free ongoing. It's just, if you subscribe, you get more features. So yeah, download that, look at the histamine foods, see what you're eating. I would definitely try a low histamine diet. Okey dokey. Shall we go on to our next question? Yeah, sounds great. So our next question comes from Heather. She says, I'm trying to get back to fasting, but I do a CrossFit type gym at 6 AM. That's so early. She said, I tried not to eat before once and I got dizzy after. Do you have any tips?

Vanessa Spina:
I'll be not going to like my tip but my tip would be to eat before you go because I tried and this is something I'll be doing this fall again now that is the fall but when we go on holiday to Greece I tend to do a different kind of fasting I call it circadian rhythm fasting and I have breakfast quite early I usually around seven and then I fast until dinner and I love it and it works really well and so I just want to provide a reminder that there's lots of different ways to fast and I was getting great results I was getting more deeply into ketosis when I was doing that I'm interested to test again this time because that happened the last few times and I could feel it as well as I was testing but really interestingly you know you get quite a lot of time fast did like so if you have a meal early in the morning I guess for you would be like at 5 or 5 30 or something and then you you know your eating window would be pretty short say at the most it's an hour and then you fast until dinner you're still fasting like 22 hours in the day it's still a long time you know a fasting so I think there are different ways to fast in terms of dizziness other thoughts I have are that it could be related to electrolytes so I'm not sure if you supplement with electrolytes but it's funny to me because I know I worked out fasted for so many years and I love doing that and I think a lot of people enjoy fasted workouts but I always felt great doing it so if I had ever felt unwell or dizzy or anything then I would have definitely changed it up so I'm just sort of speaking to what I would personally do if I was in that situation I would try having a meal before which I recently started incorporating a pre-workout meal and I've really been enjoying the workouts I've been getting and so I think it can also you know another thing to think about is also like what is the outcome that you're optimizing for because you might still be able to get there easily even if you have a meal before you workout if that makes you feel better if you are working out fed you're still getting a lot of the like the majority of the benefits from the workout it's not taking anything away from your exercise because if you burn fat more fat during your exercise fasted then you know you're still going to get the similar benefits from burning more carbs potentially while you're working out because you're going to burn more fat later so I think it all kind of evens out and the important thing is that you're doing an exercise and CrossFit is intense so I would definitely probably get dizzy as well if I was doing CrossFit fasted and that early in the morning it's just from what I've seen I have never tried it but I've seen it a lot on social media and it looks extremely hardcore and intense so that would be my suggestion what about you Melanie

Melanie Avalon:
Yeah, I thought, so I thought you were going to recommend, remember when we had that conversation about eating protein only before a workout?

Vanessa Spina:
Can we talk about that? Yes. And so that was, I had found some really interesting research showing that you get similar rates of mitochondrial biogenesis. A lot of people do facet workouts because of the purported mitochondrial biogenesis. But as I've been talking about in the last few episodes we've done, you know, there was a recent research review done showing that that pathway does not exist in humans from facet workouts. So you, the reason that people were still getting the mitochondrial biogenesis from eating protein before the workout was because of the workout. Just like doing it facet, it was the workout. So doing it fed, even if you have things other than protein, you're also going to get the benefits of mitochondrial biogenesis. It's the workout that does it. So I don't think it matters whether you're in the fed or facet state. And that's something I recently changed my mind on that I believed for a long time this recent research review came out and they looked at all the data in humans and they found that pathway exists in rodents, but it does not exist in humans. So it's really the workout that causes those adaptations. So that's why my answer is different.

Melanie Avalon:
Yeah, no, thank you for that. It's so, so helpful and fascinating. I'm glad you can speak to it, especially because I, well, I'm similar to you in that I, like, CrossFit is really intense. I applaud people who do it. I personally, I'm not a good person to ask because I don't do CrossFit. I personally just don't like working out in the Fed state at all. So what I would do, which I don't even know if this is an option, and this is ironic because a lot of people would say not to do this, but I would experiment with eating more the night before. I'd be curious what your actual eating window is. You might find that if you can eat more the night prior, because in a way you're eating window, I've heard like this quote from somebody like you're eating window, you're sort of fueling for the next day. So you might be able to find a combination of food that you could eat before bed that would, you know, last and make you feel okay at 6 a.m. I do like the electrolyte recommendation as well. And we have a link if you want free samples from Element. So you can go to drinklmnt.com/ifpodcast, and that will get you a free sample pack of Element. So check that out. Yeah, I really feel like that's, I can't really think of any other options. Yeah. Anything else? Yeah. I think that pretty much covers it. All righty. So now we have a question from Lisa. The subject is Inflammation in Juve. And would you like to read this, Vanessa?

Vanessa Spina:
Sure. So of all the supplements and or therapies like the Juve that you've tried, which do you feel is best for inflammation? Do you still love your Juve like you did in episode 77? I'm making my way through the episodes and wondering if your opinion has changed since then. Is there a way to search your website for this? If there is, I couldn't figure it out, but we'll keep trying. Thanks, Lisa.

Melanie Avalon:
Awesome, awesome, Lisa. Wow, 77. So many podcast episodes. I was reflecting the other day on just how many podcast episodes has been created and same with you. What episode are you on now with your Optimal Protein podcast? We just passed 600. Oh my gosh, that's crazy. So yes, I still, I love red light therapy. I use it and near infrared. So red and near infrared therapy, which is what the jouve devices are. I use them. I use it every single day of my life. I use it to regulate my circadian rhythm. So I light my apartment with it in the morning and in the evening. I do targeted treatment on my body. It's very rare, but when I do have muscle pain, I, it's amazing how incredible it is. I actually, I also love, I interviewed Forrest Smith at Kineon and he has a targeted, a targeted laser red light device that it's small and you can actually strap it to different joints on your body or you can like hold it places. And it's a game changer for really, really targeted therapy. And Vanessa also has her tone lux devices, which are incredible red light therapy devices as well. So I have, yeah, I have not changed my opinion. I still love and adore red light. I think it's great for inflammation. The, uh, you can use the code Melanie Avalon for discounts on jouve and Kineon and tone lux, I think all the things as far as other things for inflammation. So honestly, so fasting, fasting is amazing for having an anti-inflammatory response on the body. It's probably one of my favorite things, honestly about fasting and then what you eat in your eating window, eating an anti-inflammatory diet for you because different people react to different things. I just think is so, so key. Like that's the foundation for me is the fasting and the diet and then adding on things to there. I think the best supplement for inflammation, the reason I launched Avalon X with Sarah peptase was because of how potently anti-inflammatory it is. It's amazing. It's a proteolytic enzyme. It actually goes and breaks down problematic proteins in your body, which your immune system can be reacting to. And so that's why it can so miraculously address inflammation in so many different parts of your body because it's, you know, breaking down those proteins all throughout your body that might be causing problems. That's why I made my Avalon X Sarah peptase. And again, the coupon code Melanie Avalon will get you 10% off that AvalonX.us. Other things for inflammation, cryotherapy. People often ask me why I do cold exposure and cryotherapy. And one of the main reasons, well, it's mostly how it affects my mood and how it affects my feelings of inflammation. And I've heard a lot of people say that as well. So because people will get out of the cryo chamber before me and they'll make that comment. And there's a lot of studies on that as far as how cold exposure can regulate the the immune system. I feel like those would probably be my main things. What's interesting is my CRP level, which that's a marker of inflammation in your body. Mine's been a flat line for years and years. So I think all these things are working pretty well. I also do take lotus naltrexone, which has an anti-inflammatory effect. I've been on that for a few years. Try to think if there's anything else. What are your thoughts, Vanessa? Do you talk about the anti-inflammatory benefits of your red light device?

Vanessa Spina:
I do. And actually it was amazing because I had this really bad shoulder pain. I had like a really stiff neck and shoulder and I know it's because of sleeping in the wrong position and breastfeeding at night and everything. And just with my kids, like sometimes they will just fall asleep on me and I'll get stuck in a certain position. Anyway, I don't usually have much muscle pain. So I don't really have an opportunity to use the red light for that. So I was like, hey, I have an opportunity to try this. And I literally had tried everything. I had tried cutting out some things I thought could be causing it, you know, some kind of reaction. I thought maybe it was oatmeal or gluten related. I think I mentioned that to you. And then I got a massage and that relieved the pain for a couple hours. And then it came back and it was like that kind of stiff pain where, you know, when you turn your head and you're like, uh, really uncomfortable and hard to not think about it during the day. And I was sitting on the couch. The kids had fallen asleep on me and I had the red light. I had my red light gem, which is the portable one, handheld one. And I put it between my shoulder and the couch behind me and I just did red and infrared for like 40 minutes. I just, cause it's got an automatic timer after 10 minutes and I just kept turning it back on, turning back on. And I got up and I was like, Pete, it's gone. And this has happened to me so many times with other things that have happened, even like infections. It's crazy how effective it is, especially for pain relief. And I think also the warming, the heat, especially with sore muscles. I mean, there's a reason that athletes use this for muscle recovery because I did also think, well, what if I just tweaked it when I was working out? Because I've been working out way harder and way more. It's like, what if I just tweaked it when I was working out? But I think it was, yeah, just some unrelated muscle pain. I was just amazed. And the next day it was still gone and I had it for two weeks, you know, and it was like suddenly after 40 minute session with the red light, it was gone. So I think it's extremely powerful. It might be the most underrated wellness tool that exists. I mean, it's so science backed. It does so many incredible things. Cause even if you're doing a session on say your face for boosting collagen and elastin production and the fibroblasts of mitochondria in your skin, you also have cell free mitochondria that circulate. So no matter where you do a session specifically on your body, you're getting systemic benefits on the mitochondria throughout your body as well. So in the future, I think everyone will have red light in their homes, just like a hairdryer. Like there was a time when no one had hair dryers and now everyone has one in their homes. So I think it'll be one of those things that'll just, at some point it'll be omnipresent in everyone's homes. And we're just kind of on the, you know, the cusp of it right now, sort of some people who are more like into biohacking and stuff have it. But if you have a device, you know how amazing it is. And it's just, again, we're talking about in the last episode, like the different ways that we disconnect from nature. It's just a way of reconnecting with nature because we are indoors so much. Most of us are indoors 90% of the day or more behind glass. And we don't get that red light from the sun that we get naturally when we're outside. And so this concentrated red light therapy and infrared from panels is just, I think one of the most powerful tools for lowering inflammation and for even pain relief in the moment. I don't think it could work for every kind of pain, but if it's muscle related or otherwise, there are lots of different examples of things that you wouldn't even think that it would work on. And it does. So it is, yeah, it's so powerful.

Melanie Avalon:
It's so amazing. I remember one of the first times, similar to your situation where I did have some pain and I put the red light on it and I was like, oh, it's gone. It was just gone. It was shocking. When I first did it, I remember the first time I would hold the light over it and it would go away and then I would remove the light and it would come back and I was like, that's really interesting. Yeah, I didn't wait. Cell-free mitochondria, I didn't know about that. They float around and what are they powering? It's in your blood cells. Gotcha. That makes sense. That's amazing. So how can people get your device?

Vanessa Spina:
you can get it by going to ketogenicgirl.com. I have my collection of red light therapy panels there and there's several different sizes. And then I also have the crystal face mask, which I am obsessed with. And I use it in the mornings because it helps me stay consistent with red light with having a toddler and a baby. It's just really hard to have the time in the day to go sit in another room in front of a panel. But with the mask, I can just put it on and I can still interact. So I think it's a huge benefit to be able to be hands-free from it. But that's the Tone Luxe collection and it's at Ketogenic Girl. And yes, you can get 20% off with that Code Melanie Avalon.

Melanie Avalon:
I told you this last time I got it set up and then charged it now it's ready to go I just have once I get it in my habit. I know I'm gonna keep doing it I need to make it part of my nightly habit. Yeah habit stacking habit stacking. Yes. Yes No, it's really it's really wonderful that you have made that mask Especially because a lot of like the ones I'd used in the past Directly for the face where you had to like lay underneath it still it wasn't like an actual, you know Something that strapped to your face

Vanessa Spina:
Right. Yeah. And I really want to know what you think of it because I think that a lot of them are creepy, but I think that I think mine is pretty cute, but I want to know what you think when you try it on.

Melanie Avalon:
It's so funny. I love it so much. Awesome, awesome.

Vanessa Spina:
I've got my Halloween costume all set so with your mask. Yeah, just put that on be a biohacker. Yes I'm a biohacker just answer the door with that or go to a party with that and I'll be done. So funny

Melanie Avalon:
I love it. I know I should just wear it out like out in the world. Yeah, why not? Let's normalize it. Do they let you in stores with masks on like that? So good question. Is that like illegal? I feel like ever since the pandemic and people wearing masks.

Vanessa Spina:
I think it depends what state you're in. Like in California, pretty sure you'd be fine. Depends where you are probably. It's so funny.

Melanie Avalon:
Love it, love it. Oh, and she wanted to know, is there a way to search the website? Yes, there is a search bar on both. Well, okay, so a few different things. There's ifpodcast.com/stuffwelike. And there's also melanieavalon.com/stuffilike. And you can just search on that page for things. And then you can also search the entirety of the website of both websites, their search bars, like in the top, on the top. And the good thing is, because there are transcripts of everything, everything is very searchable. So things should come up. Okey dokey. Shall we go on to our next question? Sure. So this question comes from Jodi. The subject is starting IF and Jodi says, Hi, I just started listening to your podcast and I'm super intrigued. I am a nurse practitioner and very interested in health and fitness. I did the whole 30. And since then, I'm eating a dairy free lifestyle. She says, also a petty free lifestyle. We're wondering if she means paleo. We're not quite sure. She says I could lose five pounds and I would love to keep it off. I work out five to six days a week. I have young kids and we eat dinner around 5pm, making me done eating by 6pm. Won't I be starving the next morning? I mean, I wake up now ready to eat breakfast. Does it take a while to get used to it? Is it bad if you don't do it every day? I appreciate your input on how to start with such a crazy life with work and kids. Thank you.

Vanessa Spina:
I've heard different recommendations for this over the years. I think Dr. Sachin Panda, who's the scientist who really put time-restricted eating on the map, he always says, start with just pushing it back an hour. If you usually have breakfast at 7, then start having it at 8. And then after a while, start having it at 9, start having it at 10. Just push it back. Maybe gradually, you get to the point where you're having it at 10, or 11, or 12, depending on what kind of fasting window you want to have. Technically, according to the international consensus on fasting terms, 14 hours is the minimum. So if you were to have breakfast at 10 AM, you would still be doing intermittent fasting. And if you're closing your window by 6, that's still an 8-hour eating window with a 16-hour fasting window. So 10 from where you are now, if it takes some time to get there, I wouldn't be worried about how long it takes. I definitely think that there's probably an adjustment period. But hormonally, it's not usually a time that most people feel really, really hungry. A lot of people don't actually feel hungry in the morning. And I think part of that is from having coffee in the morning, which has an appetite suppressant effect. But most people hormonally tend to be hungrier later in the day. And I think that that's why intermittent fasting has sort of taken off so much, that so many people have been practicing it in the last years, is a lot of people just find that they're naturally not that hungry in the morning if they're not eating out of habit. But it's definitely going to be different for different people. So I would say, don't worry if it takes you some time to get there, and don't be afraid to get there gradually and slowly.

Melanie Avalon:
I mean, it's interesting that she says she is somebody who wakes up ready to eat breakfast, and it could be that she is one of those chronotypes that actually is hungry in the morning. I feel the same what you were saying, Vanessa, about, you know, a lot of people hormonally don't actually want to eat in the morning. I mean, I know that's me for sure and a lot of people, but something that's interesting is our hunger hormones adjust to our circadian rhythms if we follow consistent ones. So, ghrelin, for example, is a hunger hormone, and it makes you feel hungry, and it can adjust based on your pattern. So, like Vanessa said, if you go slow and slowly change things, it can adjust as well. It could be something, it's kind of like what I recommended earlier, and again, it goes against contrary wisdom, but if you definitely don't want to have a breakfast eating window, you said that you're done eating by six, you could try having a longer eating window in the evening. I know you're done eating with the kids at six, but maybe you could have something before bed. That's another possibility if you wanted to extend the eating window in the evening to make it easier in the morning. And does it take a while to get used to? So, yes, the body, you know, makes these adaptations. I mean, the good thing is you've done Whole30 before, so you've made food choices, which in theory should be supporting your metabolic health and your insulin sensitivity and all the things, but fasting can definitely, you know, take a bit to adjust to. We actually, on a recent episode, we talked about some studies that looked at how long it took people's hunger signals and things to basically for people not to be hungry while fasting. And it seemed in general that after a week or two, people often would adjust to whatever fasting window they were doing. Is it bad if you don't do it every day? Of course not. Like, definitely start wherever you're at, adding something, okay, how do I say this? Adding something beneficial to your life, in my opinion, is never a bad thing. It's not bad if you add just a little bit of it. That's good. And then you can keep going from there and adding more. I do really like Vanessa's ideas about going slow. I would have a reframe around because people often think, oh, life is so crazy, I don't have time to do this. One of the amazing things about fasting is how it actually frees up time. So I would completely reframe that if that's possible. Once you take the time to figure out the eating window that will work for you and plan the meals accordingly, now you're going to free up all this time where you would have been prepping meals that you're just not. So you're going to get time back. It's going to take a little bit of time in the beginning to create the system and think it through and plan it out and try it. But once you connect into that, you're going to get back so much time. It's also almost easier to start. I think it's easier to start fasting when you're busy because it distracts from hunger. I think one of the hardest ways to start fasting would be if you weren't busy at all and you were just like doing nothing, laying around, not eating, that would be pretty miserable for me. So yeah, I think that's a lot of options. Sure. All right. And then we will end with one more question from a different Nicole. She wants to know, what are your biggest regrets? Vanessa, do you have big regrets?

Vanessa Spina:
I tend to not be someone with a lot of regrets because I feel like life is always sort of working itself out for us in different ways. Things that we're ready for appear for us when we're ready for them. And it's sort of, you know, the way that life unfolds, like when they say when the student is ready, the teacher appears kind of thing. But the one forget I was trying to think of was if I had any regret, it would be that I did not continue resistance training. So when I, when I was in my early 20s, I got into a phase when I was doing, I always did a lot of cardio, you know, to just like manage my weight overall. But I had this period of time in my early 20s when I was in university and I went to the gym and I did, I lift, I did resistance training, I lifted weights, and then I totally moved away from it. I don't know why. Like, I don't know why. I would love to go back and ask myself why. I just don't know why. It just kind of faded out of my life and I started doing more yoga. And yoga is great, but it's great for, you know, flexibility, stretching everything. But I wish I had just kept up the resistance training because I would be so much further ahead where I am now. And I've managed to make a lot of progress in the last four years when I really recommitted to it. But now that I know everything that I do about it, I wish that I had been, well, it's two things actually, prioritizing protein and doing resistance training from that time on. I mean, I would be so ripped and jacked now. Like, it would be awesome. I wish I could go back and, you know, it would just be so amazing for my metabolic health to have built up all that muscle and get all the benefits from exercise, all the autophagy. You know, I mean, I would have been really hot all the time. But yeah, that's probably my biggest regret in, yeah, just in life in general. What about you?

Melanie Avalon:
So, I'm really similar to you in that I don't like to live in a regrets-based mindset. I like to see everything as learning experiences and even really hard situations I went through. I always saw them as challenges and knew that I would grow and learn and good things would come from them. And I really like that mindset. And at the same time, I guess if I could change something kind of similar, I wish that I had done growing up. I wish I had done more musical theater, I wish I had pursued that more. And I wish that I had done dancing. I think I would have had a better, I think I would feel more comfortable in my body. I feel like now I'm making up for lost time. It's like I just recently discovered how fun dancing is at weddings and parties and Taylor Swift parties. And yeah, I wish I had done dancing more. And I wish I had appreciated growing up similar to you, Vanessa. Not the exercise per se, but on the diet side of things. I went through such a period of time in high school and middle school when I was haunted by skin issues and trying to lose weight and all those things. And I wish I just realized the power of food quality choices rather than dieting and calorie counting. And I just wish I had realized the profound effect that the food choices have in your body, which I didn't realize. I didn't realize that until I read Rob Wolf's book after graduating college. I was doing actually fasting and low carb before I really appreciated the whole foods type aspect. But yeah, the good thing is every day is a new day. You can always, always do new things and have no regrets. So awesome. Anything else from you, Vanessa, before we go?

Vanessa Spina:
Yeah, I'm not surprised we have similar. Yeah, not the the musical theater one though. I'm it's it was interesting to hear that and I'm sure if you you know think hard enough there's definitely things you can regret but I definitely feel like you that you know everything is a learning experience it makes you ready for the next thing. Yeah, I love that you share that mindset but I had so much fun with you on the episode and I love the questions that we got to answer so thank you to everyone for sending in your brilliant questions and we really appreciate everyone who takes the time to do that and I'm looking forward to the next episode.

Melanie Avalon:
Likewise, I feel the same. I echo all of it back to you. Thank you so much to the listeners for the questions. If you would like to submit your own questions, you can directly email questions at ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. And the show notes will be at ifpodcast.com/episode396. Those show notes will have a full transcript as well as links to everything that we talked about. So definitely check that out. And you can follow us on Instagram. We are I a podcast. I am @MelanieAvalon. Vanessa is @ketogenicgirl. I think that's all the things. Anything from you, Vanessa, before we go?

Vanessa Spina:
I had such a wonderful time and hope that you have a great rest of your day. Thanks to all our listeners. You too. I will talk to you next week. Sounds great. Talk to you then. Bye. Bye.

Melanie Avalon:
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by Podcast Doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Vanessa: ketogenicgirl.com

Original theme composed by Leland Cox and recomposed by Steve Saunders.

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Nov 10

Episode 395: Intestinal Microbiota Study, Probiotics, Hunger Hormones, Protein Pacing, Paradigm Shifting Science, Over Fasting, Being Cold, And More!

Intermittent Fasting

Welcome to Episode 395 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Vanessa Spina, author of Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

ONESKIN: Founded by a team of all female scientists, OneSkin is the world's first skin longevity company, with products shown to reduce your skin's biological age! OneSkin addresses skin health at the molecular level, targeting the root causes of aging so skin behaves, feels, and appears younger. It’s time to get started with your new face, eye, and body routine at a discounted rate today! Get 15% off OneSkin with the code IFPODCAST at https://www.oneskin.co

SEED: This episode of The Intermittent Fasting Podcast is brought to you in part by Seed. Seed's DS-01 Daily Synbiotic is a 2-in-1 prebiotic and probiotic formulated to support gut health, skin health, and overall well-being. With clinically and scientifically studied strains, Seed's Daily Synbiotic promotes digestive health, boosts immune function, and enhances your body's nutrient absorption. Start your journey to a healthier you with Seed's innovative and effective synbiotic formula. Go to seed.com/ifpodcast and use code 25IFPODCAST to get 25% off your first month of DS-01®!

BUTCHERBOX: Grass-fed beef, organic chicken, heritage pork, wild-caught seafood, nutrient-rich, raised sustainably the way nature intended, and shipped straight to your door! For a limited time go to butcherbox.com/ifpodcast and get a whole turkey, turkey breast OR spiral ham in your first box. Plus, get $20 off your first order with code IFPODCAST!

To submit your own questions, email questions@ifpodcast.com, or submit your questions here!! 

SHOW NOTES:

ONESKIN: Get 15% off OneSkin with the code IFPODCAST at https://www.oneskin.co

SEED: Go to seed.com/ifpodcast and use code 25IFPODCAST to get 25% off your first month of DS-01®!

BUTCHERBOX: For a limited time go to butcherbox.com/ifpodcast and get a whole turkey, turkey breast OR spiral ham in your first box. Plus, get $20 off your first order with code IFPODCAST!

Repercussions of intermittent fasting on the intestinal microbiota community and body composition: a systematic review

Listener Q&A: Heather - Cold like Elsa

Get 15% off with coupon code MELANIEAVALON at melanieavalon.com/hilu!

Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.

TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.) 

Melanie Avalon:
Welcome to Episode 395 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of "What, When, Wine" and creator of the supplement line AvalonX. And I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of "Keto Essentials" and creator of the Tone Breath Ketone Analyzer and Tone Lux Red Light Therapy Panels. For more on us, check out ifpodcast.com, melanieavalon.com, and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Melanie Avalon:
Hi, everybody, and welcome. This is episode number 395 of the Intermittent Fasting Podcast. I'm Melanie Avalon, and I'm here with Vanessa Spina. Hello, everyone. How are you today, Vanessa? I'm feeling great.

Vanessa Spina:
How are you feeling?

Melanie Avalon:
I am good. I've had a crazy few couple of nights the past few nights, some of which I will not share on the podcast, but some of which include my power went out again. Do you guys get power outages in Europe?

Vanessa Spina:
No, in Asia, we did all the time. We had backup generators and stuff on our house, but here, not really.

Melanie Avalon:
Oh really? Oh wait, that's so interesting. It's like a common thing in Asia.

Vanessa Spina:
Uh-huh. Yeah, they're like called rolling blackouts or brownouts or when I lived in Manila in the Philippines, we had backup generators on the house. So like the power would go out a few times a week and you would just like everything would turn off and then a few minutes later it would turn back on with the generators and yeah, very common. A few times a week? Yeah, it was very normal. Just like part of life, especially in Southeast Asia. I don't know if it's the same now. Like that was when I was in high school. So it might be better now. Yeah. And China sometimes, not as much, but yeah. But in Europe so far, no. Do you get a lot of them where you are?

Melanie Avalon:
Well, wait, quick question in Europe, are the power lines above ground or underground?

Vanessa Spina:
above ground. But I don't know because I don't actually, you know how in North America, you kind of like see these big power stations. Actually, there is one. I found one on a hike. Not too far. And it was out. Yeah, it was above ground. Yeah.

Melanie Avalon:
Okay. Yeah. Yeah. I don't know. My apartment complex here must just be, I don't know, it keeps happening. When I grew up, our house was on a hospital line. So we never got power outages ever because of the hospital. I remember when I was a little kid, it made me so sad because I like wanted a power outage. Like I wanted to like camp in the house and like all the things. And now I'm like, Oh my goodness. Like it goes out for a second and I panic. Yes. Just gives me gratitude for modern day life. I don't think I could do like the old days. I mean, I guess I could.

Vanessa Spina:
Yeah, absolutely. I think every day the way that we live is so amazing and it's like the richest kings and queens or emperors of the past couldn't even have some of the small things that everyone has these days that we take for granted, like indoor plumbing, like a dryer. Actually, those are a luxury item in Europe. Not everyone has dryers, but having a dryer is a huge luxury. Just having appliances, power, lights, yeah, all the things. Although on the other side, our technology is also creating really unnatural situations for us. I read yesterday that blue light is causing the eye to attack itself. It's just like...

Melanie Avalon:
Oh, like an autoimmune condition in the eye?

Vanessa Spina:
Yeah, I mean, I actually only read the headlines. I didn't read the study yet, but I was like, oh my goodness, but it doesn't surprise me because our environments are so...

Melanie Avalon:
unnatural. I used to literally get in arguments with chat GPT like every night. I'm like, what is modern life? I'm like arguing with a computer and then feeling bad about arguing with it and apologizing to it.

Vanessa Spina:
So, are you having some bad nights of sleep or?

Melanie Avalon:
No, I'm actually pretty, I'm pretty good with sleep. I mean, that's another ironic thing about the technology that like we probably slept better as, you know, before all of this, but I can use all of the modern technology to help myself sleep, like the cooling mattress, the cooling blankets, the, you know, all the things.

Vanessa Spina:
It's really funny how we have to hack our way back to nature. I was telling my father-in-law, as we were walking in the forest last weekend, and I was telling him all about grounding and how amazing it is and how I kind of dismissed it as kind of an airy fairy thing. Like, I don't know, just a nonsense pseudoscience years ago. And then it turns out that, you know, apparently in Russia, kids learn in school that the earth is negatively charged and the atmosphere is positively charged. And we used to believe that it was a sodium gradient, you know, on cells, although this is still taught in textbooks. So I guess we still believe it that the reason why our cells have negative voltage, like negative 70, negative 80, negative 90, a hundred voltage on our cells is because of the sodium differential, the ion differential between the sodium potassium inside and outside the cell.But turns out it's actually this crystalline water that is holding charge and really healthy cells have a negative charge on them and positive. And they've done studies where they've looked at the cancerous cells have really positive charges on them and grounding because the earth is negatively charged is a way that you can get rid of excess negative charges. I know you know this well, but I was explaining it to him and I'm like, he's a rocket scientist, so he's really smart. And, you know, I'm, I'm trying to make it sound not woo woo, but he also gets quantum mechanics and how fascinating it is. So he's very open-minded about stuff. But yeah, it was, it's just funny how there's all these things that I think in previously we knew and cultures that were really advanced had this knowledge too, and we're sort of rediscovering it. It feels like we're just rediscovering a lot of it right now. Oh my God.

Melanie Avalon:
So, the episode that Scott and I just recorded for the Mind Blown podcast plug, we did it on out of place artifacts. Have you gone down that rabbit hole? Oh, it's so interesting. There's all these different artifacts that we found historically that don't, like, either they don't match timelines of what we thought. They indicate technology like way before we thought people had technology, or they indicate advanced civilizations, or they indicate people being places that... It's crazy. It was really interesting. So, it's things like there's this map that was created in the 1500s that shows an accurate depiction of Antarctica, which makes no sense because they hadn't been to Antarctica, and Antarctica at that time was under snow, yet it shows the shape of Antarctica, which there's literally no way they could have known that. So, it's like, where did this map come from? Things like that, and things like there's the Baghdad Battery, which is like an ancient battery, which indicates some sort of civilization had electric power ability. Yeah, it's stuff like that. You would really like it. It's a rabbit hole for sure.

Vanessa Spina:
Yeah, my father-in-law was also telling me that, you know, Pangaea, I thought that was just one time that the Earth was one continent or one unified landmass, but there's been like seven. Like back and forth? Yeah, and it goes back and forth, and he was telling me the names of all the different ones. Like, I only learned about Pangaea in school, but there's seven others, and the landmass on the Earth keeps growing apart and then going back together, and it's all because of like the fault lines and everything. I had no idea, and it's one of those facts, like some of the things you're talking about where you just go through your whole life thinking one thing, and then someone drops something on you, and you're like, what, there's seven others, there were seven others? Like, it's just, yeah, that sounds like a really, really fun episode.

Melanie Avalon:
What's weird is that modern-day archaeologists tend to be really resistant to the ideas because it disrupts the timeline that's assumed. But there's just so much evidence, like there's literally, we just find stuff that doesn't match the timeline. But so they'll like try to fit, they'll like try to come up with theories that explain away all these artifacts when maybe they just indicate that things were different. I don't know why it's so shocking that there would have been an advanced civilization that got like wiped out. Like, I don't know why that has to be controversial.

Vanessa Spina:
Yeah, I've always thought that there was. It probably has to do with our egos, but I always thought that there were civilizations that were more advanced, been completely wiped out that we don't even know about. It's one of those things that's so hard for people to change their thinking, especially when they've built their careers on it. Like when I was talking about, you know, some of the things we're learning about this fourth phase of water, this crystalline water, this water that's inside our bodies, it's like this gel-like water, it can actually hold charge. It can actually, one of the experiments they did, it powered a battery, speaking of batteries. And this knowledge means that we have to completely rewrite all biology, physiology, biochemistry, all the textbooks have to be rewritten.It's like, who wants to do that? So none of the scientists who built their careers on established ways of thinking, they don't want to go back and say that all their work was wrong. You know, it takes a lot to have a paradigm shift, but it's also very exciting when a paradigm shift does happen. And at some point, it's almost like it gets to a point where you can't resist it anymore. It has to sort of manifest, which is really interesting. We're totally on some wild tangents

Melanie Avalon:
Well, I was thinking I was thinking that the related theme is I bet the one thing we have been doing a long time is fasting. Maybe I wonder if these ancient civilizations. Hmm, who knows?

Vanessa Spina:
I know in Rome, I read about how the Romans used to do something called the Senna. Have you heard of this? It's C-E-N-A, and it meant one meal a day, and they would eat one meal a day. And I got really into this when I was doing OMAD, and they would basically have one principal meal in a day. Sometimes they would snack. It's very sort of awful, Ori, not awful, Ori, awful maker, awful hoary maker, Ori, awful maker. But during the time that I was doing OMAD, I remember researching it. Yeah, it was very much like most Romans could only afford to have like one main meal a day. And that seems similar to probably how a lot of us ate, or a lot of not us, but humans ate in the past, because if you were hunting and gathering, like you just didn't have that consistent food supply, you kind of had to fast.We were watching a nature documentary with Luca yesterday, and it was talking about the lion diet, which is like they basically hunt and have to have a big kill every two days. So they feast, and then they don't, on meat, and then they don't eat for two days, usually two or three days, depending. But I was saying to Pete, I'm like, I wonder if they had access to food around the clock. Would they eat around the clock, or would they still just eat every two, three days?

Melanie Avalon:
That is really interesting.

Vanessa Spina:
you probably could tell that from a zoo. Yeah. I'm going to ask the zoo because sometimes we go, they'll be like feeding the tiger, the lion. Like I should ask them if they eat every couple of days or if they eat every day because they're at the zoo.

Melanie Avalon:
I know that like zoo animals get a lot of mental, like they'll get like mental health issue problems and things that wild animals don't get, which is not surprising. Can you imagine your life in a exhibit?

Vanessa Spina:
No, it's horrible. Yeah, living in captivity. I think there are some animals, I remember in Vancouver where I lived, and this will be the last thing I'll say about totally off the wall topics, but they had an aquarium in Vancouver that was the world's first aquarium that every single, like most of the animals, I don't know if every single, but most animals there, the large mammals, they were all rescues. So they rescued them from the ocean and helped rehabilitate them. So every single one of them were rescues. I think some of the animals they say, especially at the Prague Zoo that we go to, that a lot of them are endangered, so they're helping them reproduce and build up their population. So it does make me feel better about it, but otherwise I get really depressed at some of the exhibits because I don't like seeing them in captivity. It's much better. When we went to the safari, we got to see them all in the wild and that was much more exciting, which I definitely wanted to do again.

Melanie Avalon:
And you can't really release them after they're in captivity because they can't handle the real world. I was reading about that in one of the authors that I interviewed. She was talking about basically this idealized view we have of the animal species that's just not accurate. We use it as a model for what is natural human behavior, but she makes the argument that animals don't actually act that way like we think they do. It's a whole tangent. But we'll use examples of how different animals seem to be inherently empathetic, but she makes arguments that it's not empathy. It's just the way the social structure and hierarchy is. But in any case, apparently you can't really release the animals that are in the zoo because they can't reintegrate into the social hierarchies and or they come back when the free willy-whale made me so sad. Hey, go. So yeah, on that note, animals fasting.

Vanessa Spina:
I was going to go into another weird tangent about what I learned about killer whales.

Melanie Avalon:
Oh my goodness, wait, tell me really quickly. What?

Vanessa Spina:
They're not that nice. They're killers. They kill seals and all kinds of other dolphins. They kill dolphins. We saw that in the nature documentary we were watching sometime in the last year. It really upset me. We all kill, I guess, to eat, but they were killing them for fun, for sport. So yeah, kind of changed my opinion.

Melanie Avalon:
There's been like, I've been seeing, well, not, I haven't been seeing them, but I've been hearing people talk on podcasts about recent videos of whales attacking, recently a whale just attacked a boat, a killer whale.

Vanessa Spina:
I remember that when that was happening, like it started surging or something. They were having these big attacks.

Melanie Avalon:
Can you imagine being on a boat and just, Oh my goodness. That's terrifying.

Vanessa Spina:
Terrifying. All right, I shared my last random.

Melanie Avalon:
I love it. I could talk about it all day. Shall we jump into some fasting-relieving things? Yes, I would love to. All right. So to start things off, we have a quick study to discuss. This is called Reprocussions of Intermittent Fasting on the Intestinal Microbiotic Community and Body Composition, a Systemic Review. So this was published in Nutrition Reviews in March of 2022. And long story short, it ended up looking at 17 studies. What I thought was actually really interesting in the beginning was of these studies. It said most of them were either alternate-day fasting or time-restricted feeding setups. I just thought it was interesting because they make a conclusion right at the beginning of those two different approaches and the two different ways that those affect metabolic signaling throughout the body.And they said that time-restricted feeding, which tends to be what people listening to this show are often doing, it's where you're eating in time windows during the day, right? That's the definition that we agreed upon from that article, Vanessa, essentially. Yes. Yeah. We recently, we'll put a link to it in the show notes, we recently talked about a study that gave official definitions to all the different types of fasting. So that was helpful.

Vanessa Spina:
I just have to quickly say that I interviewed the author, one of the main authors, and he said that he was also frustrated with some of the terms. But he said, at least it's something, you know, it's some kind of consensus. And I was like, okay, I'm just glad we're on the same page. But I'm going to be interviewing him for this podcast.

Melanie Avalon:
Yes, thank you. That's amazing.

Vanessa Spina:
Listeners submit questions for him. That's Dr. Grant Tinsley. He spearheaded that consensus on fasting terms, but he's also done a lot of really interesting intermittent fasting research.

Melanie Avalon:
Did he not like how some of the fasting definitions included? He's also, yeah.

Vanessa Spina:
He's also a purist like me, so we kind of got to bond over that.

Melanie Avalon:
Did he say other people felt that way as well?

Vanessa Spina:
No, he just said, so I just said, look, to me, it's like, okay, it's similar to saying you have sleeping, and then you have modified sleeping, which is laying in a bed, like listening to a book. And I'm like, but that's resting, it's not sleeping. So to me, that's like saying modified fasting is eating periodically something even if it's low in one macro, you know, or if it's even just only one macro when it's like a fat fast. And he was like, I love that analogy, I'm going to use it. He's like, I also feel the same way. But I understand. I mean, they had a lot of experts on the panel. And anyway, I just wanted to, yeah, let you guys know after I interviewed him what, yeah, if what his thoughts were on that.

Melanie Avalon:
That's amazing. I love that. That's so fun. Were there any other fun takeaways?

Vanessa Spina:
From not really on the the fasting study, I think they just had so many experts on it. And, you know, they just really saw a need to have consensus. So hopefully, it'll be the start of something. And I think that they were able to like something like protein pacing, which is a really cool study that I loved, but to me was not intermittent fasting, because they were eating protein every so many hours. To me, that shouldn't be in the category of intermittent fasting. It should be called something else like protein pacing, which is so cool as a concept on its own. So something like that, I don't think would fit into that definition if people now are using that consensus. And because there were so many experts on that panel, it should have a lot of influence on people who are publishing studies on fasting, whether or not they can use the term fasting or not, which will cause a lot less confusion.

Melanie Avalon:
It's so interesting how debated it is, like I recently interviewed Katherine Arnston again on my show for Energy Bits for her spirulina, and she's all about, for example, that spirulina doesn't break the fast, but it's like a fasting-friendly food, and I just think it's such a different — because I don't agree with that — I just think it's such a different paradigm. There's definitely like two types of people, like people who think fasting is, you know, just water, essentially, or coffee, and then gray zones.

Vanessa Spina:
Yeah, I'm about to interview her again, too.

Melanie Avalon:
Oh, cool. Cool, cool. Yeah, she's really up to this up on the science of spirulina. It's really impressive.

Vanessa Spina:
She really should get like an honorary PhD, although I think she is going for her PhD. Oh really? But she should get like some kind of Nobel prize or something for her work on algae, it is amazing.

Melanie Avalon:
It is. It's really, I'm really grateful for everything she's doing for sure. So okay, going back to the study, like I said, what I thought was interesting was they concluded right at the beginning that time restricted feeding influences weight control and biochemical parameters by regulating the circadian system. So our sleep-wake cycle, improving satiety control systems, oh, and improving satiety control systems by acting on leptin. So basically they were saying time-restricted feeding works because it affects our circadian rhythm and it affects our hormone that makes us feel full, which is leptin. They said on the other hand, ADF leads to a reduction of around 75% of all energy consumption regardless of dietary composition in addition to promoting hormonal adjustments that promote weight control.So for ADF, they were saying it was calorie restriction and hormones adjusting. I just thought that was really interesting that they, especially because we've been talking about you know, is intermittent fasting, the effects, are they just due to calorie restriction or are they different? I thought it was interesting that this study, even though it wasn't even looking at that, made that conclusion about those two approaches. In any case though, one of the major takeaways, and it was a long study, but the main takeaway is they were looking at how fasting affects the gut microbiome and the intestinal microbiota community in your body, specifically the firmicutes bacteroides ratio, which is the dominant strains. And so these strains are not strains that you can take in a probiotic. They actually represent around 90% of our gut microbiome, but they are not, like I said, they're not transient and they're not something you can take in a probiotic pill.So there's the gram-positive firmicutes and the gram-negative bacteroides. I always struggle with saying that. And their composition and relationship has a huge role in obesity-related metabolic changes and weight loss in the immune system and all the things. And the takeaway of the study was that fasting seemed to really beneficially affect that ratio in our body for the better for our metabolic health. So their conclusion, for example, they said, in short, the ADF and time restricted feeding protocols have a positive effect on the remodeling of the intestinal microbiota and can possibly be used to control body adiposity, improve insulin sensitivity, and achieve other obesity-related metabolic changes. These fasting protocols demonstrated a positive effect on the intestinal environment, specifically on the quality of the intestinal microbiota, which in turn has been associated with the amelioration of several diseases such as inflammatory bowel disease and changes in the gut-brain axis.So yes, do you have thoughts on this study, Vanessa?

Vanessa Spina:
I thought it was an absolutely amazing review. I had read different papers over the years that talked about this and anything that has a positive influence on the microbiome in that way, especially with regards to that population and the ratio of fermicutes and bactroides because it does have an influence on body composition really fascinatingly. I just thought it was such an amazing review because it really summarizes some of the benefits that are not talked about as much when it comes to intermittent fasting or time restricted eating, which these days are really equated a lot with caloric restriction. And so it would be interesting to know how much of the effect is from time restricted eating or ADF versus caloric reduction. If there is how much overlap, how much of the benefits happening when it comes to the intestinal microbiota are coming just from the fasting and how much is from the caloric restriction aspect of the fasting, if you know what I'm saying.

Melanie Avalon:
Yeah, exactly. And what's interesting is, that's why I thought it was so interesting. In the beginning, what they said where they separated ADF from time restricted feeding, because they don't even mention calorie restriction as part of my restricted feedings, like mechanism of action. You know, that's really, really interesting.

Vanessa Spina:
It is and it also I think I was listening to a researcher who's I'm interviewing in a couple days on intermittent fasting and he was saying what's super interesting about ADF is some people like they're talking about in the study do reduce their caloric intake by as much as 75%. Then other people will do a fast for 24 hours and in their own mad they'll overcompensate to eat and match the calories that they would have missed from their whole 24 hour fast and it kind of depends on the person but I think in general most people significantly reduce their caloric intake from that from a man yep.

Melanie Avalon:
It's, it's so, so fascinating. And I think it's also a good clarification. I mentioned this already, but I think with the microbiome, I don't think a lot of people have a realization about these essentially indigenous bacteria populations that we can't modulate them really through like probiotic supplementation and such. So it's, it's really interesting that fasting can have such an effect on them and weight loss and weight gain. For example, when we take probiotics, those are different strains that can survive in oxygen. They tend to be transient. That's why you have to keep taking them. They don't, they don't colonize your, you know, gut and stay there and you're good. You have to like keep taking them. So for example, like today's episode is actually sponsored and part by seed, which is now my like favorite probiotic ever.Like I've experienced so many benefits from it. And I don't like to blanket prescribe probiotics to people because like I said, there's so many different strains and different things work for different people, but their company that their entire mission is researching the science of probiotic strains and what helps people. And they have so many studies. For me, I've noticed a lot with my skin and my GI health. And I mean, I just love them. So I tell everybody about them. People can try them out at seed.com/ifpodcast and they can use the code to five. I have podcast to get 25% off their first month of DS zero one, which is their, their probiotic. So I highly recommend that again. So I think like the, it sounds like an amazing approach to really optimizing our gut microbiome, which we know affects so many things is not just our food and the probiotics we take, but the, the fasting as well. So basically you could be 24 seven improving your gut microbiome, I think by fasting and then making supportive food choices in your eating window. So that's really, really, really exciting. Especially if you dive deep into this article, they talk about all the different effects that the gut microbiome has on, you know, other hormones like our, you know, ghrelin or hunger hormone, leptin or satiety hormone, GLP one. So people are, you know, familiar with GLP one agonist, their, their effects on GLP one from gut microbiome, another peptide called peptide P Y Y appetite control, and then inflammatory markers. So many things. So we're talking, we're talking in the beginning about what we don't know about the past and history. There's also so much we don't know just inside of our bodies with our microbiome. That's a whole civilization inside of us.

Vanessa Spina:
Yeah, it's amazing. And I'm so glad that you shared this review because it really is a really excellent one summarizing all the benefits, especially when people, you know, critique or reduce intermittent fasting or time restriction to just, you know, the caloric reduction.

Melanie Avalon:
Yeah I think it's so so much more. Okie dokie, shall we get into some listener questions?

Vanessa Spina:
I would love to. I just wanted to mention that have you seen that Firmicutes and Bactroides have been rebranded?

Melanie Avalon:
No.

Vanessa Spina:
So, I interviewed this expert on the microbiota. She was actually an exercise physiologist that studied the impact of exercise on the microbiome. She was really fascinating. And when I was interviewing her, she told me it was kind of funny because there were a lot of articles about how this renaming caused this massive uproar because people were really annoyed by it. Anyway, so for Mikutis was renamed basiota, basilota, B-A-C-I-L-L-O-T-A because it contains the genus basilis and Bacteroides was reclassified and split into two, Prevotella melaninogenica and Prevotella intermediate.

Melanie Avalon:
Okay, I have seen those words.

Vanessa Spina:
Yeah. So it's like, I don't know why they need to do that. You know, it doesn't make much sense to me when, you know, everyone knows these names, is pretty familiar with them. But yeah, formicutes, basiota and proteobacteria. Yeah, it's, it caused an uproar in the scientific community. It's kind of like, it reminds me of when, you know, when they declassified Pluto as a planet, it was like, oh, it's like so sad. But when they just make these big changes and you're like, what committee decided this and why are they spending their time on this? But, you know, maybe, maybe the new names will be more beneficial in terms of understanding what they're actually made up of. So I guess the point with formicutes was that because they contain bacillus, their basiota. So anyway, maybe they'll catch on, but I don't think a lot of people know that they've been renamed. When was that? You said, I think it was in 2022. So it's been a couple years of people are, you know, this review was 2022.

Melanie Avalon:
Yeah, I wonder if it was like right after this.

Vanessa Spina:
Yeah, probably. But also, I just don't think a lot of people know.

Melanie Avalon:
I've definitely seen those words. It's interesting because it's kind of like, oh, okay. So I heard this on a podcast recently. I don't remember who was talking about it. And I didn't go look up the origin story of it. It was a, and it was a passing comment, but the passing comment was something about how we call it adrenaline or we call it like norepinephrine or epinephrine. Wait.

Vanessa Spina:
nore or noradrenaline epinephrine norepinephrine you had it pretty much

Melanie Avalon:
Okay, so the passing comment was that the reason for that is like it just comes down to like a personal thing that happened, like a drama situation type thing, you know, like different opinions. It just came to like down to a personality drama thing in the past for why that happened. I feel like there's like a lot of drama in the science world, you know, like it's just like any other social group. So, it really makes you wonder like, you know, decisions we've reached and ideas we have. What are the stories behind all of them? Yeah, good things have been different ways. It kind of ties into our theme in the beginning about, you know, being presented. It's like such a theme. I love that. Me too. No, thank you for sharing that. That's interesting. And that explains now why I've seen those words.

Vanessa Spina:
Now we all know, but are we going to use those terms? I still call Twitter, Twitter.

Melanie Avalon:
X I don't think Twitter's ever gonna I'm like how long is it gonna be like the formerly known as Twitter or like Twitter aka X like is it gonna change I don't

Vanessa Spina:
I do it on purpose because I just think it's so inane to change it. And you know, I'm a huge Elon Musk fan and I still like purposely call it Twitter because I'm like, no, I'm just gonna change the name on me. Yeah.

Melanie Avalon:
What do they call it now? They call it tweeting? What do they call it instead? Exing?

Vanessa Spina:
Right. I should ask my husband because he's a big Twitter person, ex-person. I'll ask him, but it's probably tweet. I don't tweet a lot. I literally just use Twitter to go on there and connect with scientists that I want to meet for the podcast. Because a lot of them, they're not on Instagram or TikTok. They kind of, I think, look down on it because it's like, you know, there's a whole mess of things on there that are pseudoscientific, but a lot of them do hang out on Twitter. So I go on there just to check messages. And then sometimes I go on and there'll be some scientists who's like, yes, I'm available this week. And I'm like, oh no, this is like five months ago.

Melanie Avalon:
Oh my gosh. I feel like you should have changed it to something more analogous like chirper or something like something that would be

Vanessa Spina:
Even Exer, like anything.

Melanie Avalon:
Anything not just not x I don't go there so I don't I get scared

Vanessa Spina:
Yeah, it all goes back to, you know, naming things and

Melanie Avalon:
If you just sit back and think about the concept of virtual communities, it's kind of mind-blowing. It's not even a real place, but it's this fake place in our minds that we somehow connect with other people and we never even meet them in real life. It's kind of mind-blowing.

Vanessa Spina:
It is and it can totally take over your life. Like there was a point in my life when I got so involved with my online community that I was really neglecting like my in-person life community. And I had to make like an intentional change to stop, like focusing so much on the online. Cause it's like, I barely ever get to meet people online in real life. And like, yeah, we talk all the time, but I need, I need to start investing in like community locally. And I had to make that intentional shift. And it's been so wonderful to actually invest more in my community locally. And it's nothing against online community. It's just sometimes it can draw you in so much that it can sort of take over where you're like, I don't really need to invest in my real life community because I have such a vibrant online, you know, community.And, but we need, you know, in like real life connection, meeting up with people, having friendships and stuff on people that you can actually see on a regular basis to connect with this. There's so much that goes on when you're in person with someone compared to online.

Melanie Avalon:
There was one study on longevity, and they were looking at different populations, and in that study, the factor correlated the highest to longevity, I think, was, it wasn't the quality of social interactions, it was the number of social interactions, in-person social interactions, which could be like, is it just the number of people you meet in real life, or is that because in order to meet a lot of people daily, that means you're like going out and, you know, moving around and getting food and, you know, things like that, I thought that was really interesting. So, oh, we're about to answer a question, yes. So, our first question comes from Heather, and the subject is Cold Like Elsa, which I love that title, and she said, hi, with lots of exclamation points. She said, I've been fasting for about two months now, I average 19 hour fasts, around hour 16, I start to get very cold, is this normal? Could this be when my body enters ketosis? Cold, do you have thoughts on cold and keto? Ketosis.

Vanessa Spina:
So I don't know if any data is showing a link between cold and ketosis, but what comes to mind is that the body might be just going into some form of like energy preservation. That's what I would think is happening because one of the things that the body can do to save on energy is to shut off heat production. And so it could just be that towards that part of the fast, you're running low on like stored glycogen. So maybe you're it's, it's connected to switching into fat burning, which that could then be entering into ketosis depending on the person. So I think it's, it's a good idea. I don't know of like actual any, I don't know of any research saying that the body gets cold at that point, probably because it hasn't been measured that I'm aware of, although it could have been measured and I'm just not aware of it. Maybe Melanie, you know something about that.

Melanie Avalon:
Yeah, so honestly, I thought this was going to be easier to find information on than it was. What I did find that I thought was really interesting, I found a study called core body temperature energy expenditure. And there it is epinephrine during fasting, eukaryotic feeding and overfeeding and healthy adult men evidence for a ceiling effect for human thermogenic response to diet. It was actually looking at the changes in core body temperature and the thermic effect of food based on the meals you eat, but they did look at bi temperature while fasting. And some of the explanatory information was actually helpful for me. So they talked about how half, this is interesting. So half of our metabolism is actually go actually goes towards maintaining a stable core body temperature, which I did not realize.The reason I think that's really interesting to think about is that means that's a big, that's a big ratio of energy in our metabolism that can be sort of tweaked or played with depending on I'm not trying to make this too casual, but depending on the brain's interpretation of how it's responding to an energy deficit and where it wants to make adjustments accordingly. And that was my first thought when I read that. But then as I kept reading it kind of supported that because it talked about how there are there's this theory that people are either have like a spin thrift, like a, like a thrifty metabolism or not. So basically some people's metabolism seem to be, if, if there's like an energy deprivation, they kind of lock down and don't as freely burn energy anymore. And those people can be more resistant to weight loss and more prone to weight gain.And so people who have this like thrifty metabolism, it says, it literally says that it's defined by a greater decrease in energy expenditure during fasting and that these people have a lower core body temperature. So basically, if you are the type of person who has a more genetically thrifty metabolism, it's likely that while fasting, you'll get colder because your body is going to just willingly decrease energy expenditure. And that's going to directly affect core body temperature since 50% of our energy expenditure goes towards our core body temperature. And we also talked in another prior episode about fastings effect on thyroid hormones. And a lot of the studies we looked did see a decrease in T3 without an overall negative impact on the thyroid. It was just like a transient decrease in T3 and T3 raises body temperature. So fasting lowers that.That would be another reason you might, you know, get cold while fasting. So basically, it seems like it is a normal response and it can vary based on the individual. If you want to feel warmer, I have some suggestions. So ironically, doing cryotherapy, which is deliberate cold exposure every day, that actually increases your brown adipose tissue, which is your type of body fat that's purpose is to keep you warm. It actually has more mitochondria and it generates heat to keep you warm. And cold exposure can increase that throughout your body. So you can actually build up your inner thermostat in a way by building up this brown adipose tissue. And it's not necessarily gaining weight. It's more transforming your current white adipose tissue to brown adipose tissue. Also, what you eat in your eating window can have a big effect on your body temperature during the fast. At least this is just me speaking from my personal experience. But for me, it's so obvious. So if I eat like a lower protein, if I have a lower protein night, I will be colder the next day. If I have a higher protein, I'll be warmer the next day. It's shocking the difference. If you want to really heat up, add some MCT oil to your meals. At least for me, that turns me into a generator and I'm so hot the next day. So I don't like being hot. I prefer being cold. It just feels intuitively better. So I actually really like, I don't like it when I, because of my meal, have residual effects of feeling hot the next day, especially in the summer. But yeah, so I do think it is a normal response. I think it depends on your personal metabolism. Of course, if you're over restricting, over fasting, overdoing it, you could be entering a place where it's too much for your body and that cold is a problem. I don't know if she was concerned about it. I think she was just asking, but those are my thoughts on cold during fasting. Do you have any other thoughts?

Vanessa Spina:
So I was going to say it used to be my issue for most of my life. I was always the cold person and I hated it except for in the summer because I was always very comfortable. And now I am always the warmest person because I eat so much protein. And in the winter, it's fantastic. It makes me cold adapted. I don't have to wear a lot of layers. Actually my friends constantly remark on how I'm wearing a tank top in winter. I mean, I will usually put a jacket on, but sometimes I will walk out without it. And I feel amazing. I love it in the winter this summer. We've had a really hot summer in Europe and I have been not liking it, not enjoying it at all, especially on really hot days. I just get so hot and like I'm showering a couple times a day and I just don't, I really don't like being hot, you know, getting too hot as well.So I need to find ways to cool off. And, you know, it's the one thing I've been thinking about a lot this summer. I'm like, I love everything about my high protein diet except for this. And this is the first summer that it's really bothered me where I'm like, maybe because I'm also wearing my baby a lot, like in the baby carrier. So that adds a lot of the keys really warm. So when I'm walking around the city, I have this like little heat pack on me on top of that and it makes me long for the days when I was fasting all the time and under eating protein and I was freezing. Like there's been a couple of days where I'm like, man, just want to like fast for a day just to be cold. But thankfully we had a bunch of rainstorms on the weekend and the temperature is finally cooling off.It's going back to a nice cooler temp, but on the hot, hot days, it is not great. I have to say I have to, it's something I still have to hack and figure out like how can I do high protein, get all the benefits except for this raging thermic effect in the summertime.

Melanie Avalon:
we know that decreased metabolism and like a lower, a lower metabolism throughout your life without a negative thyroid function is linked to longevity, which is a little bit counterintuitive. And we talked about that on a prior podcast. But for me, this is why just like the cold, it just feels like less inflamed. I just don't like feeling hot. I just, I really don't like not a fan. Do you get hot at night? I do.

Vanessa Spina:
but we keep a really cold room. And actually I had some of the better sleeps I've had all summer because the temperature finally cooled off. So we had the AC on top of that, but we like, I would sleep in like 16 Celsius. I don't know what that is in Fahrenheit. I can Google it, but it is 16 Celsius is 60.

Melanie Avalon:
Okay, yeah, that's, yes, we would get along really well. That's what I pretty much sleep in.

Vanessa Spina:
Yeah, so how do you stay cold even though you eat so much protein? I need your help. Like right before I go to bed? I mean, just all the time, like during the day, like on a hot day.

Melanie Avalon:
Just to show you how much I, because I eat right before bed, so that's when I'm like at my hottest. So I have the air conditioning on, I have a cooling mattress. And now I have this Hylu blanket, which I'm obsessed with. I talked about it earlier, but it's made of graphene fiber fabric. And it, because of the nature of that fabric, from what I understand, that fabric wants to exist at 64 degrees. So whatever it's touching, it either like gives energy or pulls away energy to make that thing 64 degrees. So if you're hot, even though it's a blanket, it pulls heat out of your body. It's amazing. I'm so obsessed with it. And so listeners, if they're interested, you can go to melanieavalon.com/hilu, H-I-L-U, use the coupon code MelanieAvalon for 15% off. What's fascinating about it is it's really thin. Like it's so magical. I'm like, how is this magical, thin, smooth thing like changing my body temperature? It's really heavy too.

Vanessa Spina:
But how do you stay, okay, how do you stay cold during the day?

Melanie Avalon:
one less comment about that. So no, no, no, no worries. Just to show how important this is to me. So when my AC went out the other day, because it went out at like, or AC, okay, that's how much I value the AC. It wasn't the AC, it was the power. But as a consequence, the AC, it went out at like 7pm. And I was like, okay, it'll probably come back on in an hour or two. I wasn't getting updates. Normally they give us updates. So by like 10 or 11pm, I'd already gone to my parents, recorded a podcast, come back. Then I was like, I guess I got to go sleep with my parents because I can't sleep without like air conditioning. So I went back to my parents at like midnight.And then I got a text being like, it's coming back on at 3am. So then I was like sitting at my parents at midnight and I was like, do I just go back and wait it out so I can also have my cooling mattress and my so I did I literally went back and forth multiple times and I came back and sat in the dark from like 1am to 3am just sat on the couch like praying for it to come back on. But I needed my cooling mattress and my highly blanket.

Vanessa Spina:
I understand now why you're feeling a little rough when we started.

Melanie Avalon:
Oh, no. This was a few nights ago. Yeah. So no, I'm pretty much always exhausted in the morning. I just not sometimes I'm better at hiding it than others. But what you asked about during the day.

Vanessa Spina:
Yeah, because the nighttime I'm good, it's like during the day.

Melanie Avalon:
I honestly, I, so if I were to add, this is a reason that I eat high protein, low fat. Another reason, because I find that if I eat high protein, like high fruit and lower fat, and this is just me. So friends don't like take this as gospel. That combination, especially if it's, okay, actually, you know what, I have found that different types of protein have different heating versus cooling effects. And this is a thing in Chinese medicine, and like I have this massive book, it's called like healing with whole foods. It's this massive manual that goes through basically every food ever created, and the TCM interpretation of those foods. And foods are considered in TCM to be either like cooling or warming. And so I have found that fish protein, normally the majority of my protein is fish.So it's scallops, bare moon tea, a little bit of salmon. If I eat high fish protein, I don't get massively hot. If I eat a ton of chicken, for example, I'm like burning up or like steak burning up, even though it's the same amount of protein, which is really, really interesting to me. So if my diet is high protein, but from fish and fruit and low fat, I'm okay with the temperature. But if it's like lots of chicken and steak, I'll be pretty hot. So I eat less of that during the summer months. It's okay, like you were saying during the winter.

Vanessa Spina:
Chicken is crazy because when I weed chicken breasts, I eat a lot of it and I get so hot from it. I should just do that in the winter. Chicken is steak and try to do more shrimp and fish in the summer. I love salmon. I eat it quite a bit, but I'm going to try that on really hot days. Last week, we had a week where it was over 100 every day Fahrenheit. Yeah, it's just hot. If I was cold, it makes me want to do some kind of fasting routine or something just to feel cool because I miss that feeling of just never feeling overheated no matter how hot it was outside. It's just a nice thing to be comfortable. I'm going to try that.

Melanie Avalon:
Yeah, you should go down the rabbit hole of Googling the different the TCM temperature of the different foods. So like shrimp is actually hot in TCM, but scallops are neutral. Chicken. Let's see. I love this conversation. No, literally, Vanessa, I went through a period of my time where I was obsessed with this, like while I was eating, I would have that manual and I would just read about the foods.

Vanessa Spina:
They know so much. When I was doing my biomedical science program at U of T, they had an option after to do TCM, and I really considered it. I still think about it sometimes. But one of my favorite things I learned from that is food combining. You know, they're like, don't combine fruit.

Melanie Avalon:
with meat. Yeah, I know. I disagree.

Vanessa Spina:
I thought you might, but yeah, I love the knowledge from that. So that's, that's really cool. I want to know which are the cooling foods. I'm totally going to try it all out.

Melanie Avalon:
It's a thing. Okay, so chicken, this makes sense. So chicken and TCM, it's known for its ability to tonify blood. I can't say these words. Key and Jing. Okay. But it helps to regulate blood and expel cold. Literally.

Vanessa Spina:
Expelled cold.

Melanie Avalon:
Yeah. So literally it's making you hot. Let's look at steak. Steak, also tonify, same thing. And it's also, yeah, it's warm. What's the other thing? Salmon. I think salmon, pretty sure salmon's, oh, salmon is considered warm in temperature.

Vanessa Spina:
So it's like other kinds of fish.

Melanie Avalon:
Bear Moondi. Let's see. I think it's like whitefish. Whitefish is neutral.

Vanessa Spina:
So my thing with whitefish is I have to add something to it like hollandaise because chicken and beef I can just have lean but fish like white salmon I can have it you know it's got some fat in it but it's relatively lean but whitefish I need something with it just like flavor wise or something.

Melanie Avalon:
Have you tried bare moon tea that I talk about all the time? Do they have it there though? Australia's bare moon.

Vanessa Spina:
should look. I remember wanting to look it up after our first podcast together, yeah, a few years ago.

Melanie Avalon:
Oh my goodness, I'm that obsessed with it. I'm talking about it all the time. Yeah, the problem is they probably don't have that Australia's brand and I want to be super clear with listeners. This is not all bare moondi because the Australia's brand is the one that raises it in tanks and they monitor it for mercury, but it's a fatty whitefish. It's a lean, fatty whitefish. It has the highest omega-3 content of any whitefish. It's delicious.

Vanessa Spina:
And obviously it's probably a little mercury.

Melanie Avalon:
Yes, yes, they literally, they monitor it for that.

Vanessa Spina:
So if I were to find Barramundi here, I would want it to be from Australia.

Melanie Avalon:
Oh no, no, sorry. Australia's is the brand. Oh, and they don't even call it that anymore. So glad we're talking about this. It's called The Better Fish now is the brand.

Vanessa Spina:
I just found it. The better fish. Okay. Astralis.

Melanie Avalon:
Do they have it?

Vanessa Spina:
in Prague? Yeah, I don't know. It's probably it's a dot com. So I will try it. And if not, I'll try it when we're home. But I love this conversation.

Melanie Avalon:
Me too. Oh my gosh, we like talked the rest of the episode. Yeah, I am.

Vanessa Spina:
I think it was important though, because other people doing high protein have got to be dealing with this in the summer as well.

Melanie Avalon:
I think it's so fascinating because I think people don't like if you didn't realize this was all a thing that these foods have different temperature effects, you wouldn't know that you could actually biohack the protein you're eating to change your body temperature.

Vanessa Spina:
Is that the only cooling one? The whitefish?

Melanie Avalon:
So whitefish was neutral, scallops were neutral. I think, let's see what egg is. Egg white, oh, egg white is known for its ability to clear heat. I have done some clear heat, clear, yeah, get rid of it.

Vanessa Spina:
heat. Okay, because before they were saying like clear cold or something clear heat, they were expelled cold. Okay, so this is expelling heat. That's what I want. Egg whites, I eat so many egg whites. So maybe I just have egg whites.

Melanie Avalon:
Oh, chicken was saying that it expelled cold, but it was warming. Wait, wait, but that, oh, wait, that makes sense. Yes. Okay. Right. These are opposites. Okay. I was thinking that they were supposed to be the same thing. Yes. These are opposites. So chicken like warmed you up and egg whites literally cool you down.

Vanessa Spina:
I'm going to try the next time we have a really hot day because it, yeah, it really affects me. So I'm definitely going to try it.

Melanie Avalon:
I think you'll find if you, okay, so say you have like a day where you just eat, and I have tried this before, right? Just had egg whites as my protein and I will be cold the next day.

Vanessa Spina:
egg whites and white fish. I could do scallops and then it would affect me the next day, not that, not the day of the next day.

Melanie Avalon:
Oh, well, I'm doing it in my perspective of I eat before bed and then it's like the residual effects. Yeah.

Vanessa Spina:
Well, I'm going to take notes and I'm going to report back. Please do. Yeah.

Melanie Avalon:
I will. This is so fun. Let's look at what looks like. I wonder if they have whey protein. Let's see. Oh yeah. So in TCM, dairy products are seen as, I can't say that word, phlegm producers, not a fun word. Oh, here it is. Cow's milk is considered warm and sweet. Yeah, I don't know.

Vanessa Spina:
Well, thank you for sharing all that. I have hope for my super hot days and you know, we really delve deep on this question.

Melanie Avalon:
I know. You have to try some experimentation and report back, so and listeners as well. And for listeners, if you would like to submit your own questions for the show, you can directly email questions at ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. The show notes for today's episode will be at ifpodcast.com/episode395. Those show notes will have a full transcript as well as links to everything that we talked about. So definitely check that out. And you can follow us on Instagram. We are I have podcast. I am Melanie Avalon. Vanessa is ketogenic girl. And I think that is all the things. So anything from you, Vanessa, before we go.

Vanessa Spina:
I had so much fun. I loved the question we talked about on the episode and the theme of the podcast today was super fun, esoteric information, really enjoyed it and can't wait for the next one. Likewise.

Melanie Avalon:
Have a good rest of your night, and I will talk to you next week. Sounds good. You too. Bye. Bye.


Melanie Avalon:
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by Podcast Doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Vanessa: ketogenicgirl.com

Original theme composed by Leland Cox and recomposed by Steve Saunders.

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts - it helps more than you know! 

 

 

Nov 03

Episode 394: Special Listener Guest: Amy Wrenn, Unexplained Weight Gain, Perimenopause, Biohacking, Functional Medicine, Prescribing GLP-1, And More!

Intermittent Fasting

Welcome to Episode 394 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Vanessa Spina, author of Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

True Nutrition: Create your own dream customized protein powder (including grass-fed options!) with over 60 enhancers and flavors and zero fillers! True Nutrition sources the highest quality ingredients tested multiple times for purity and potency. For a limited time get 15% off your order at TrueNutrition.com with code IFPODCAST.

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To submit your own questions, email questions@ifpodcast.com, or submit your questions here!! 

SHOW NOTES

True Nutrition: For a limited time get 15% off your order at TrueNutrition.com with code IFPODCAST.

LMNT: Go to drinklmnt.com/ifpodcast to get a free sample pack with any purchase!

BUTCHERBOX: For a limited time go to butcherbox.com/ifpodcast and get a whole turkey, turkey breast OR spiral ham in their first box. Plus, get $20 off your first order with code IFPODCAST!

Amy's introduction to intermittent fasting

Perimenopausal weight gain

Social push back to weight loss

Amy's fasting window and eating pattern

Nutrition to support exercise

Getting injured and recovering with red light

Joovv: For a limited time go to joovv.Com/ifpodcast and use the code ifpodcast for an exclusive discount!

Food choices

NAD+ injections and patches

Ion Layer: Get $100 off with the code melanieavalon at melanieavalon.com/ionlayer!

Being a Nurse Practitioner

Prescribing GLP1s

Episode 388: Special Guest: Dr. Naomi Parrella, Weight Loss, Fat Loss, Semaglutide And GLP-1 Inhibitors, Fasting With An App, Muscle Loss, High Protein Diets, And More!

Tips for new fasters

Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.

TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.) 

Melanie Avalon:
Welcome to Episode 394 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of "What, When, Wine" and creator of the supplement line AvalonX. And I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of "Keto Essentials" and creator of the Tone Breath Ketone Analyzer and Tone Lux Red Light Therapy Panels. For more on us, check out ifpodcast.com, melanieavalon.com, and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Melanie Avalon:
Hi, everybody, and welcome. This is episode number 394 of the Intermittent Fasting Podcast. I'm Melanie Avalon, and I have a very special guest here today on the show. So we have been doing some episodes on this show, which are a little bit of a new and different format, which is interviewing you guys about your intermittent fasting stories. And it's been really, really fun. And honestly, some of the inspiration for it has been reading listener questions on the show and really enjoying when people share a lot about their stories and just wanting to know more. Today's guest, I am so excited to be here with. It is Amy Wrenn. She's from Orlando, and she has a really incredible story about her Intermittent Fasting journey and something we'll talk about. She's actually a nurse practitioner, which it's always so, so exciting to see the world of intermittent fasting enter the medical field.So I'm really, really excited to touch on that. We were chatting before this, but I just have so many questions for you, Amy.

Amy Wrenn:
Thank you so much for being here. Thank you so much for having me. I'm excited to be here.

Melanie Avalon:
So you were saying you've been listening to this show for how long? Since

Amy Wrenn:
2019? 2017? Yep. 2019. 2018. 2018. One or the other. A long time.

Melanie Avalon:
You've been on the journey with us then for quite a while. And that actually relates to how you first started intermittent fasting or had you said that you found it through an Instagram reel, which now I'm thinking about, do you remember the actual reel you saw? Like, well, what was the magic in it that made it really land with you? I'm being selfish here trying to like figure out how to make better...Reels. It's kind of a rabbit hole.

Amy Wrenn:
I, so are you familiar with the Holderness family? They have, they probably have a TikTok and a YouTube, I don't know, but I used to, I still follow them on Facebook and they're in their forties and they make like cute, they make cute videos together. And they also have a podcast, which I was not listening to, but one day I was watching and she looked so good and I was a little bit like jealous. I'm like, how is she looking so good? I am struggling over here. And she mentioned this thing called intermittent fasting. And she mentioned that she was seeing this doctor in North Carolina, a functional medicine doctor. Well, she's actually an MD and a functional medicine doctor. And they started talking about it on their thing. And I was like, I want to do this. I want to learn more about it. So I just got on my phone and went into the podcast and I just typed in intermittent fasting and your podcast was the first one that came up.So I press play and listened to episode number two and was like hooked from there. And I think you and Jen on that particular episode was like, what's your top 10 favorite things about fasting? And you both went through your top 10 favorite things. And I was like, Oh my God, there's, this is more than just weight loss. There, there's a lot of things that go with this. And I just, from there, I listened. Cause I don't know. You guys were not on like episode 200 yet, but there was well over a hundred episodes. So I, as I started fasting, I listened to you guys every single day. And it was really great because I felt like I had a support group cause you know, fasting, the weight loss is not fast. And I feel like a lot of people fall off because they want to see that number on the scale.They want to see their clothes fitting differently. But what got me through that period of not really seeing any changes was listening to you guys every day, just repeatedly say about all the other changes that are happening in your body and all the different health benefits and listening to the questions. And so I had my own, like very own little support system through you guys. And it really, really helped bridge that gap for the first 30 days for me.

Melanie Avalon:
Oh my goodness, so crazy. It's so weird to think that I've been in people's heads that long.

Amy Wrenn:
Yeah, you have. I feel like I know you very well.

Melanie Avalon:
Okay, so questions about all of that. Before that, had you been trying a lot of different diet approaches? And if so, what were the intentions for doing that originally? Were you trying to lose weight, health conditions? Where were you at before?

Amy Wrenn:
So six months before my 40th birthday, everything changed. I am a pretty petite girl. I'm 5 '2". I've always been small. I grew up a ballet dancer. I never had to diet before. I had no coping skills for losing weight because I had never had to lose weight before. I think it was maybe to the day, six months before my 40th birthday, I stepped on the scale like I normally did and I was up two pounds and I had not been up two pounds in years with the exception of pregnancies. I had pretty much stayed the same weight. I ate what I thought was a healthy diet. I ate my three meals a day. I had snacks. I was working as a nurse and I had children and exercise. I mean, I exercised quite a bit. So I was like, what is this two pound weight gain? Then the next month, another two pounds and then the next month, another two pounds to where I got to the point where I was 20 pounds overweight, which I was weighing what I weighed in pregnancy without changing my diet, without changing my exercise.I went to several doctors and bless their hearts. They didn't know what to do with me and I know people see it all the time, but they're like, you're normal. Everything's fine. And nobody cared that because I was still considered, I wasn't obese and there was lots of people who I'm sure were like, oh, I wish I weighed that, but 20 pounds is 20 pounds and I was very depressed. And on top of that, I got acne rosacea at now 40 years old and I was having joint pain, particularly in my fingers and my knuckles, just really bad joint pain and difficulty sleeping through the night. So just all of a sudden, this like turning 40 thing punched me in the face. And for two years, I really struggled. I tried the whole my fitness pal and monitoring calories, which was just absolutely miserable.I felt like I was always hungry. I was never satisfied. If I broke down and ate something, then this whole guilt and shame and you're making bad choices. And then I tried the eating to every hours. That's something that I happened upon and that was a great way to gain more weight. And then I finally got to keto. I did keto for seven months. I think I lost seven pounds doing keto. And what I did like about keto was at least there was some science behind it. I was like, okay, this, this, their science, this is how it works. This is why it works. I never lost more than seven pounds. And I was so miserable. I really like I felt like I had to think every time I went to eat, I had to really think about what I was eating. I didn't enjoy food. I really enjoy fruit. I really enjoy a sandwich. I also really enjoy potatoes. Like it was I wasn't very unhappy with it. And I finally was like, just forget it. And then I had, so then I gained the weight back and then I happened upon intermittent fasting.And when I first started, I was white knuckling it like at 11 o 'clock, I would get a headache. And I really just that hole in the beginning where my body was not metabolically flexible. It, I had low energy and headaches. And then when I was time for me to eat, I was overeating. But because I was listening to the podcast, I knew all these things were normal. And I knew that appetite correction was going to come. And I knew the weight loss was going to come. And it did. It took some time, but it did. But I had the other pleasant surprises were my, oh, my IBS went away. It was having some bad stomach issues. My joint pain went away. My face cleared up. I had more energy. I could think better like just all the wonderful things. And what I really, really, really love is that I eat a pretty healthy diet. I feel like I make good choices, but I could eat what I wanted, I didn't have to cut any macros out, so I could eat what I wanted.It was great. And ironically, once I did lose the 20 pounds, and it did not happen overnight, honestly, it took about two years. Every time I thought I was done losing weight, and then a couple months later, I would lose a couple more pounds. And then I thought I was done, and then a couple months later, I would lose a couple more pounds. So at the end of two years, in which I'm five plus now, I did finally stop. And I looked better at 47 than I did in my late 30s. So I'm loving it. It is a way of life forever for me.

Melanie Avalon:
Like to comment on the two pounds and the 20 pounds and that whole piece. I really like talking about that aspect of it because I think there's all this focus and you kind of mentioned it as well. Like there's a big focus on people who have extraordinary amounts of weight to lose, which is wonderful when they find things that work for them with intermittent fasting. We actually, the last girl I interviewed on this show, she had a much larger weight loss that she achieved with intermittent fasting. At the same time, these smaller amounts on people, it can be just as hard. People might think, oh, you know, you're not that overweight. It's it'll be easier. But weight loss resistance is weight loss resistance. Finding the diet that actually helps you burn into that fat is can be just as hard or or easy if you find the path that works for you as it is for other people with large amounts of weight loss.And then also what we know is that the way it happens for a lot of people is that slow, steady, just gaining a pound or two every year or so, you know, like, and then you don't realize and then you wake up one day like you said, and it's 20 pounds more, which when you start from a small frame, 20 pounds is, you know, relatively a lot on your frame and any amount of soapbox here. But I just feel like any amount of weight that feels like a burden to your body metabolically and such is warranted to find something that works. So thank you for sharing your experience there with that. Did you experience like socially people ever giving you pushback about wanting to lose weight? Oh, my God.

Amy Wrenn:
I experienced so much pushback from my friends that I was starving myself. Yes, I experienced a lot of pushback in the beginning, maybe for the first year. And it's funny because his friends now come to me for weight loss advice. And it's now something now that I'm a nurse practitioner, it's something I specialize in as well. But yes, I had a lot of pushback in the beginning. But the proof is in the pudding. And I look and feel great now. And I'm very strong, I've always exercised through this and I work out fasted. And I know there's a little bit of noise right now about once you're in your 40s and working out fasting and blah, blah, blah. But I was like, you know what, this is just, it's working for me. I'm not gonna change anything because it's working so well. But yes, I had a lot of pushback, a lot of resistance in the beginning.

Melanie Avalon:
have that pushed back with all of the different dietary approaches you were trying or was it more? Nope. Isn't it so interesting? Yes. Yes, it really is. I wonder if that's because we're just accustomed to all the different dietary approaches and like trying, you know, calorie counting or trying eating different things. But the idea of not eating, I just wonder why it's so different to people and why people give it pushbacks.

Amy Wrenn:
I don't know. There were some strong opinions. I will tell you that much, some strong opinions, but I didn't let it stop me. And part of it is because I had your podcast as a resource and as a support system that really, truly helped me just keep plugging away. And I would say, so I started at the end of March, April, May, June, but three months in, 90 days in, you could tell. Other people could tell. Like, I just, I feel like I had a glow. I have this picture, my friend, and I went to a concert and I was like, that's the moment you could tell. I had a glow about me like, hey, what are you doing? You look great. And I felt great.

Melanie Avalon:
What concert was it?

Amy Wrenn:
It wasn't Taylor, unfortunately, it was Rob Thomas.

Melanie Avalon:
I recently have realized how much I love going to concerts. I feel like I didn't like going to them growing up and now I'm like, I like concerts.

Amy Wrenn:
I love concerts. So I started, there was a moment when my husband used to work for somebody that had a box at the arena downtown Orlando. So anybody who came through, we get to go see. And my daughter who's in her twenties, we saw Taylor Swift speak now. We saw the red concert. No way. Stop it. Yes. Yes. I took her to see Justin Bieber. Like, and we've been honestly, because I know you're a Taylor fan, not to bore anybody else, but like she's been getting, we've gotten every album as they've come out because my daughter grew up with, with Taylor. But yes, I love concerts too. My big love is Matchbox 20, like when I was in my twenties. And so now whenever like he comes around, I try to go and I fangirl over Rob.

Melanie Avalon:
What was their main their main song? I mean, I know like I'm getting hit with like I can see the name and I can I'm Getting hit with memories. I can't hear them

Amy Wrenn:
So in the Barbie movie where he sings I Want to Push You Around, that's Matchbox.

Melanie Avalon:
20. What was their main song though when they first came out because that's what I'm getting hit with.

Amy Wrenn:
The very first song was Push, but he did that song with Carlos Santana. What is it, Senorita? Oh, okay. Harla Mona Lisa or whatever, but that was just him. But that one was a big one on the radio. But it's like 90s.

Melanie Avalon:
So you're eating window. What approach do you do? I'm going to wrap this back into the concert. No, it's fine. What approach do you do? And yeah, what approach do you do?

Amy Wrenn:
So I typically stop eating by 8 p.m. and I don't, I typically start eating at one. And it's two meals a day. Now I break my fast technically because you messaged me on something, you probably don't know. But I take the perfect aminos. I really enjoyed your podcast with Dr. Minkoff and I read his book. So I take two servings of perfect aminos and I consider that breaking my fast. I typically do that around 12 or 12.30. And then I wait at least 30 minutes to an hour to let it absorb completely. And then I start eating and then two meals. So a lunch and a dinner.

Melanie Avalon:
Nice. When did you start taking the perfect aminos in your journey?

Amy Wrenn:
In 2021, I went to Dave Aspery's biohacking conference because you also took me down that rabbit hole and you have no idea, Melanie, you've really taken me down some rabbit holes and I love it. I'm enjoying the ride. So I met them. I did not meet Dr. Makoff, but I met the body health people there and I bought their multivitamins and listened to their talk and then shortly there and they gave me the book and then after reading his book, then I think you had asked like, hey, who's somebody who I can interview and I recommended him, some other people did too and shortly thereafter you interviewed him. I don't know if it's because of our recommendations or if it was already something scheduled, but listening to that, I was like, I need to take these because I was doing CrossFit and then also just perimenopause and it's really been fantastic. I love them. I do. I take 10 of those big horse pills every single day. I don't care. Just one at a time. I get them in. It's easier than trying to eat that much. I can't.

Melanie Avalon:
Wow. And for listeners, I'll put a link in the show notes to my interview with Dr. Minkoff. He wrote a book called The Perfect Protein. That's what it's called, right? I think.

Amy Wrenn:
I just want to look for it, but I loaned it to a friend, but I think it is called the perfect protein. It's the easy read. I read it in one day. It's not crazy long or anything.

Melanie Avalon:
because they actually pitched me for the show because, well, because of his brand and everything. And he had the book and I was like, is this going to just be like a cell for his protein? But then reading his book, it was really, really wonderful. Like, you really dive deep into the science of protein metabolism. So I had him on the show on the Melanie Avalon biohacking podcast. That was a really great interview. And I was really, I really liked the science he had in support of this idea of taking basically, basically what it is, is it's like the complete amino acid in the most pure form. So then you take it, like you're taking it, you know, an empty stomach and you're just like assimilating that your protein. So then you're meeting the needs for what you might be lacking. And actually what was really telling for me, so I interviewed him, I don't think I mentioned, I might have mentioned this when I recorded the intro, but I interviewed him, we stopped recording.And I was like, so, you know, how much should I take? And this is after me telling him how much, how much insane amounts of protein I eat. And he was literally just like, you don't need it. Oh, wow. Yeah. He was like, you're fine. Don't take any. And I was like, okay, that's really telling, you know, like he's not, he's not just trying to sell something. So awesome.

Amy Wrenn:
So cool. I noticed big changes with it too. I like just my muscle strength, my hair. My hair is one of the, I have one of those people that my hair grows to a certain length and it just doesn't grow any longer and it grew about two inches longer. And so I've just been taking them religiously ever since. They can only be helping me and I don't get the insane amount of protein in that you do. I try to eat a good amount of protein and prioritize it with every meal, but not quite what you do.

Melanie Avalon:
No, I think that's a really, really smart approach, what you're doing. I'm glad that you mentioned about it breaking the fast because I think they do, I think it's them, I'm pretty sure they say, yeah, they say that it doesn't break the fast, which I really don't know how they can say that because it's literally protein, which is literally the most anti -fasting thing.

Amy Wrenn:
Yeah. They do say, they will say that I'm on their Facebook group too. And people argue kind of back and forth on it. And I'm just like, you know what? And so whenever I offer some advice on there, I'm like, I just break my fast with it. Just break your fast with it, wait 30 minutes and then eat. It either is or it isn't just do it that way. And then you don't have to worry about it.

Melanie Avalon:
I agree.

Amy Wrenn:
but they really want people to take it, or I don't know, at least their followers, you gotta take it before you work out, you gotta take it before you work out. And I'm like, listen, I take it, I work out early in the morning and I break my fast with it several hours later. It's gonna get to where it needs to go. I'm not, you know, you don't have to do it before a workout.

Melanie Avalon:
Yes, I'm really glad that you're pointing that out. As you know and listeners know, that's like the ongoing debate. And I mean, realistically though, at least in my opinion, as long as you're not like a bodybuilder competition where, you know, this is everything, it seems like most people are fine working out and then having their protein later, just realistically, like that's what I see. And for men too, I've heard it as well. So it's nice that that's really working for you.

Amy Wrenn:
It is and I've thought about changing it like I did. I listened to, I think I messaged you about that one guest on Huberman and she almost had me second guessing myself and then I was like, you know what? I'm not going to change anything. This is working for me. I feel great. I look great. Like I'm, I'm, this is working. I'm just going to keep doing this. If it gets to a point where it's not working for me anymore, then we'll, we'll take a, we'll, we'll look at tuning things. you

Melanie Avalon:
I think that happens to a lot of people because there's so many opinions out there and they can be very convincing opinions. And it's interesting that, like you said, we'll know what works for us. It'll be working so well and then we'll still feel the need to change. The example I use is not really to Dieter Fitness, but I remember one time I was obsessed with this product that I had ordered on Amazon. I don't remember at all what it was. Like I literally don't remember. But I remember I went in to reorder it and I loved this product. And then I was reading the reviews and like reading some negative reviews. And I was like, oh, maybe I don't like this product after all. And I was like, wait a minute. Like literally I've used it. So I think we do that with diet and nutrition. And so I'm totally down for people experimenting, but also like know what works for you.

Amy Wrenn:
Yeah. I'm like, I don't need to eat a banana before I work out. Amy, you already know this. You don't need, like you don't need this, but don't do it.

Melanie Avalon:
Yeah, so true. And what type of workouts do you do?

Amy Wrenn:
So I was doing, it's not, it's more functional fitness. It wasn't the brand CrossFit, but pretty intense workouts. And then unfortunately my gym closed down and because it was a small business and it really broke my heart, maybe more than it should have, but you know, they were my family. And so now I did try some CrossFit stuff and I unfortunately ended up getting injured. And I was like, listen, listen girl, you are 47 years old. You do not have to compete with 20 year olds. Let's just find something that keeps you strong, keeps muscle on your body, keeps your bones strong, that has times of days that work well for you. So I have been going to a 45. It's actually been working great for me. I've been doing the end body since 2018. So I have a pretty good idea. Like I have a well -established baseline on there. And I have the most muscle I've ever had.And trying to get muscle on me is a struggle. It's a struggle bus. Just like, you know, it's like running uphill, especially as you get older. But I have the most muscle that I've had since 2018. So I'm like, you know what, it's working. I'm just going to keep doing it.

Melanie Avalon:
That's incredible. For the injury, did you try any of the biohacking things to help with recovery? Yes.

Amy Wrenn:
So, I'm going to tell you about a different injury real quick. One Christmas, I think it was 2019, I was maybe had a couple glasses of wine and was doing Just Dance with my children and danced right into the coffee table and I had a spiral fracture to my big toe. I do not recommend Zero Stars. Don't do it to your big toe, it's terrible.

Melanie Avalon:
Was it was a like blood everywhere type situation?

Amy Wrenn:
There wasn't, it was inside my toe. So it was very swollen, black and blue. They said I just by like a hair mist having to have surgery. I went and I got the boot. Well, I had a, like the mini Juve because of, you know, you. And at the time, I was like, my husband's gonna die at how expensive these things are. So I'll buy the smallest one, which was still like $300. I told him it was like $50, but at any rate, I was doing the red light on my toe twice a day, 15 minutes twice a day. And he was kind of making fun of me with my silly red light. And I went in at four weeks for them to do an X -ray and kind of a checkup and the doctor, he was like, he came in the room and he was like, what are you doing? And I said, what? And he's like, I have never seen bone grow this fast. What are you doing? And I was like, seriously? I was like, it's my Juve, it's my red light. I've been putting it on every night. So that is my big win for that.

Melanie Avalon:
And that's while you're fasting, right, as well? Yes. So it's nice to know that we can be building bone while fasting. I'll give listeners a link. Do you still use your juve?

Amy Wrenn:
I do, but I need to get another one because I've used it so much and I've lent it out so much to anybody, my friends who've had surgery, they, I have them use it. You know, the, it only, when you charge it, it only lasts like a minute.

Melanie Avalon:
Oh, so you have to go, the one that you hold in your hand?

Amy Wrenn:
Yeah, it's the teeny tiny guy, but it really was so wonderful. I need to get a better one. Somebody gave me a gift, a Truelight. Have you heard of that brand?

Melanie Avalon:
That's not related to true dark like Dave's company, is it?

Amy Wrenn:
I think it is because I saw them at that biohacking conference. So I have one of theirs too and I used it. I just don't know if it's as good as a Juve because I haven't heard you talk about it.

Melanie Avalon:
Oh, that's so funny. I'm trying to see if it's, I'm going to see if it's spelled the same as, okay. Oh, true dark. Yeah, so it might be, that might be Dave's company.

Amy Wrenn:
I think they were, they were there at his thing. Juve was not there, but True Light was there.

Melanie Avalon:
Oh wait, True Light by Dave Asprey, yes.

Amy Wrenn:
Yeah, okay. So I have his thing and I use that right now because it plugs into the wall. It's bigger. It's got the red near infrared and then it also has a yellow light. I don't use that one as much because I'm not as well versed on the yellow light. I do know I would not use that portion at nighttime. It just intuitively feels like there should be a morning thing if you're going to use that.

Melanie Avalon:
This is interesting. They have like a really skinny one.

Amy Wrenn:
This one's pretty big. This one's like four times the size of my like mini, mini Juve.

Melanie Avalon:
Well, I will put a link in the show notes for Juve at the very least. So if you go to melanieavalon.com/joovv, which is J O O V V, you can get $50 off, I believe with the code Melanie Avalon. And I have mine actually literally it's right here. I have the, I have the mini. So you said many earlier. So you have the go.

Amy Wrenn:
Yeah, the teeny tiny one.

Melanie Avalon:
They have a one called the mini, or what used to be called the mini. I don't know if it's still called the mini, but you, um, that one, you can like stand on your desk and that's the one I have that I, I love it. Cause you can put it on your desk and like, I have it on just during the day when I'm at the computer, I mean, on me, I just feel so good. It's, it's crazy though. I haven't had the sort of energy injury you mentioned, but I did at one point have a pretty bad, I don't know if it was a sprain or what it was, but if I would shine the light on, like when the light was shining on it, the pain would just go away, which is crazy. And then the light would go off and the pain would come back. I was like, this is, this is weird. We're just going to keep this light on. Yeah, basically. And it was when I was traveling actually.And I had that, that go and I kept having to like recharge it. So that's amazing. Okay. Oh, I love that. So going back to the fasting window. So I think we've got a good picture of what you're doing. Actually one more question. So you said you eat two meals in that window. What, what do those look like? Are they protein focused? Or you were mentioned earlier how, you know, you, you like the freedom of eating what you love. So how have your eating choices evolved?

Amy Wrenn:
So I am, I'm pretty much a creature of habit, maybe not as much as you, but I for lunch either have a salad and it always has protein in it. And it's not because like, oh, I want to be good. I want to eat a salad. I just love salad. And I really love like the chicken is warm and then the salad's cold. I don't know.

Melanie Avalon:
Oh, I know what you're talking about. I'm getting flashbacks. I went through a salad phase. Yeah, it's very satisfying.

Amy Wrenn:
Yeah, I just love that. I love like that hot and cold at the same time. I will also do a, or I'll do just do a sandwich. Like I'm just, you know, a roast beef sandwich, a chicken sandwich, turkey sandwich, ham sandwich, but I have the same thing. I will warm it up like the one size. And I put cheese on it so that the cheese is melty than the other side with like cold pickles and whatever. I just like that hot and cold thing, but I'm pretty much either having one I'm having one or the other for lunch. Like there's just not a whole lot of fluctuation and one of the two. And then for dinner, I'm either having a salad with protein or I'm having just like chicken and vegetables or potato. I really love potatoes.Like I just don't wanna live in a world where I can't have potatoes and that seven months doing keto was no fun for me. And if it's like a date night, we get steak, I'm not a pasta girly. Like I don't, I could go the rest of my life without eating pasta, but I could not go the rest of my life without potato. But chicken and steak are my favorite proteins. When we went last year, my husband and I went to Italy, it was my first time abroad and it was very exciting, but thank God there's just so much pasta. So when in Rome, you eat pasta, but I was getting scallops a lot because I know those have a lot of protein in them.

Melanie Avalon:
I love that you have this like hot cold fixation when you go to the restaurants are you like what is the hot cold combination on the menu.

Amy Wrenn:
No, I already know. When I look, I could look at a video and be like, oh, that's going to be good with the hot and the cold at the same time.

Melanie Avalon:
Oh, that's so I love it. I love it. I also love that you I I like meeting fellow people who know what they like to eat and it's a relatively not I don't wanna say limited but like you know, it's it sounds like it's pretty similar what you eat all all the time all the time and that's the way I am and I I just love it like people think it's boring and I think it's the best like I love what I eat.

Amy Wrenn:
I know what I like, you know, I'm like, and I don't like some people are very adventurous and they'll, they'll try something new for dinner. And I'm like, but what if, what if you don't like it and now you've just ruined your dinner and your time out. I just, I know what I like and that's what I want to eat.

Melanie Avalon:
Yeah, that's that's the way I am like a genuinely it's like I think some people because a lot of people and again I'm all down everybody do you Some people really need variety and like they want to eat different things all the time And I don't think they can grasp that I genuinely love eating Essentially the same thing all the time, but I do I'm the same way and it tastes so good to me. Okay, that's awesome do you find that You sounds like you always like we just talked about you're always eating the protein like if you were to Not eat the protein. Would you be really hungry?

Amy Wrenn:
I very rarely don't eat the protein because I work out a lot and I'm very aware of just being perimenopausal, so I don't do it. If I have a day where maybe I'm sick or I'm not very active, I might have a day where I push my fast out longer and it might be a lower protein day, 98% of the time I'm getting the protein in.

Melanie Avalon:
And what about, you mentioned earlier, just dancing with some wine. Do you have wine in your eating window?

Amy Wrenn:
I do. I typically keep that for the weekends, maybe one night. So what I've noticed as I have pushed past, I don't know, I'm going to say 44, I'm not metabolizing alcohol like I used to. It's very, very obvious for me. And so I've really kind of limited it to maybe one night a week, maybe two glasses of wine. And I love red wine. Red wine is my favorite. But recently, this is very exciting. I started NAD injections probably about six weeks ago, and just sub -q injections with the NAD. And initially, I wasn't like, oh, I'm not really noticing much energy. But I'll tell you what I have noticed, is I am metabolizing alcohol, I would say, like 90% better than I was before. Where before, I would just be so exhausted. I mean, I could just feel it. I could feel it in my brain. I could feel it in my body, my eyeballs. And now I'm like, I don't even feel like I had a drink last night. So it's not an excuse to drink more. I'm just when I do have my alcohol, I'm processing it better. So I'm just excited about that.

Melanie Avalon:
NAD for listeners. It's basically your body's master metabolic enzyme. It's involved in everything you do that requires energy. And so there's theories. I say theories because it's very heavily debated, but the idea is that supporting your NAD levels are great for combating stress, for drinking, for anti -aging, all the things for health. And there's a lot of different ways that you can get it in. So you can get it in. People will do IVs. I have not done an IV. Have you done an IV?

Amy Wrenn:
I have not, just doing this sub -Q right now at home.

Melanie Avalon:
Oh, at home. Oh, because you're a nurse practitioner. Is that how you can do it yourself?

Amy Wrenn:
Yeah, I mean, people can, I've prescribed it for patients to take it home, but there is a protocol where you can do every third day, you can take and you start just like with an IV, where you start and you low and you titrate up with it.

Melanie Avalon:
Oh wow, that's awesome. So do you feel, how do you feel when you actually, because when I was doing the, I did the inner muscular injections for a while and immediately after doing it, I would feel like not very, not good. Like tight chested and oh, yeah.

Amy Wrenn:
Yeah, so the first couple, the first week I did like, and I don't remember like milligrams per unit, sorry, but I did 10 units like every third day. And I was like, this is nothing. And then I did the 20 units, this is nothing. And then I got to 30 and I was like, oh my God, I'm having a heart attack. And I really oddly feel it in my legs and my chest and it lasts for about 10 minutes. And it's a very weird feeling, but I checked like my heart rate was normal, but it does feel weird. And it's the same thing with an IV. If you give it somebody in an IV and you give them too much too fast, they will have that feeling too. You got to go really slow and people have to titrate up on it. But now I'm on like, I don't know, maybe week six, seven, eight, somewhere in there. So my body's getting more used to it.

Melanie Avalon:
You described it perfectly, the feeling. It's like a very indescribable feeling, but it just feels not right. Like somebody feels like not right in your body.

Amy Wrenn:
to have a medical emergency, what's happening? Yes.

Melanie Avalon:
Yeah, what I've been, have you seen me been talking about ion layer patches?

Amy Wrenn:
Yes, I did. I looked into it, but because I can get things it costs.

Melanie Avalon:
Yeah, it is a little bit, I'm hoping it'll continue to come down and my code does give you $100 off, but basically they're NAD patches. And what I love about them is, I mean, you're doing the injections at home, which is more, what's the word accessible, but for people who are going into a clinic to get injections, this you can just do at home, it lasts up to 14 hours. It's basically like a slow drip, like an IV, except you don't feel, you don't feel any negative side effects, you just feel really energized. And I find it perfect for when I'm going out and drinking or the next day after drinking, it's just a game changer.

Amy Wrenn:
It really is a game changer. I had no idea. I did not go into this when I started it. I was like, I just want to experience it. I've never done NAD outside of maybe Quicksilver several years ago. And I was probably in it and actually not even NAD. But, and so I wasn't anticipating the change. And then it took me, I was like, wait a minute. I haven't, I haven't felt hungover. I haven't felt terrible. And I'm like, oh my God, it's the NAD. But I do want to try, is it Ion? Is that what it's called? Yeah, so it's Ion layer. I do want to try it. And I'll probably in the first of the year, try it just to see what it's like, just to experiment because I kind of like to experiment with stuff like that.

Melanie Avalon:
I'll be, you have to let me know what you like, especially comparing it to the injections. Cause like I said, I did the injections for probably a long time, maybe a year. And then I found the patches and I was like, Oh, I'm never going back. So for listeners, they can go to melanieavalon.com/ionlayer. So I O N L A Y E R and the code Melanie Avalon will get you a hundred dollars off your first order. So I love them. You just like mix up the NAD yourself and put it on the patch and off to the races. Well, awesome. Okay. I do. I love the biohacking tangents. This is great. No, it's so amazing. Question. Have you been back to Dave's conference since 20 to 2021?

Amy Wrenn:
I was able to go to that one because it was it was in Orlando because California was shut down at the time But I would love to go again

Melanie Avalon:
Sorry, you said you did or did not go to Orlando.

Amy Wrenn:
He came to Orlando in 2021. Oh, wait, 2021's Orlando? Yeah.

Melanie Avalon:
Yeah. You weren't there. But he came back. He came back to Orlando. Did he? Yeah. Yeah. That's why that's why I'm confused. I didn't know he came back. The first one I went to was in Orlando and it was not this past one. So not it was 2023. Okay. Well, the

Amy Wrenn:
a bummer. I didn't know. We just missed each other next time. You know what? My mom died last year around this time. I'm sorry. I think I was out of commission with all that and that's probably why I didn't even know. My brain was offline for a minute there.

Melanie Avalon:
Oh, I'm so sorry.

Amy Wrenn:
I appreciate.

Melanie Avalon:
that really sad. Okay, the question I had about okay, but I'm bringing it back to the concert and the social stuff and everything. So you're eating windows one to eight. First of all, how strict are you on that?

Amy Wrenn:
So in the beginning, when I was losing weight, and by beginning, I mean first two years, I was very strict, very, very strict. I did eventually for, I don't know how many months I got the app, I forgot what it's called. It was like four letters, I don't remember, but so I could clock in and clock out of my window and that helped me be mindful. And I also, at that time, I would occasionally have like a glass of wine during the week and I was like, how am I gonna break this? And so I think it was maybe Jen's suggestion. I get San Pellegrino and I put it in my wine glass. And that was just like, my brain felt like I was drinking wine and eventually I didn't need to do that like hand to mouth motion anymore. That's just a fun tip for anybody who's first starting out with it, who maybe needs to break that glass of wine at nighttime kind of deal. Once I got to my weight that I'm at now, I will make exceptions.So like if it's a weekend and there's a special event and we're out to dinner and it's, you know, I'm not gonna stop at eight o 'clock. I'm going to continue with the night and do my thing. I might push back the next day when I break my fast, but I might not, I'm more flexible with it now. But my body's super, super primed and used to this.

Melanie Avalon:
Awesome. So, so if you're going to a concert type situation, you would eat before. Yes. Yeah. And then, and then go. Yeah. Have you experimented with any longer fasts?

Amy Wrenn:
you know, not on purpose, but yes, I have done some 24 hour fast, which were, like I said, not planned, but just kind of one of those things where like, you know, if there's a, I've had some family emergencies or I've had to take somebody to the hospital and the next thing you know, it's 9pm at night and you're like, Oh, I didn't eat today. So, but not, not on purpose. If maybe I did have like a weekend where it was a little bit heavier eating or heavier drinking the next day, I might do like an 18 or 19 hour. It just depends. But most of the time I really stick to the, I stop around eight or earlier potentially, and then don't really eat anything until one.

Melanie Avalon:
I love that you found what, you know, what really works for you. It's so great. It does work for me. It's great. Speaking up hospital. So going back to you being a nurse practitioner. So how long have you been practicing that?

Amy Wrenn:
I was a nurse for 15 years doing emergency obstetrics and labor delivery, and then I went back to school and became a nurse practitioner. I became a nurse practitioner back in 2020, and I have my family nurse practitioner certification, but I work in more of an integrative space. I specialize in bioidentical hormone therapy, and I also do weight loss. I've been working with GLP1s for the last four years. I work with peptides.

Melanie Avalon:
as well. Okay. So what do you think about the whole GLP1 world?

Amy Wrenn:
I love the GLP ones. I really do. For patients who have, they come in and they're like, these are all the things I've tried. Nothing's working. And I get it because, and you know, that two year window, nothing was working for me until I found fasting. And a lot of people will say that they tried fasting, but they didn't stick it out past the two weeks. I'm very fortunate that I had your podcast because it's really what helped kept pushing me through. And so for a lot of these people, when we start them on the GLP one, and I do a pretty comprehensive labs with them as well. So I'm looking at fasting insulin. I'm looking at inflammation markers, hemoglobin A1C, thyroid hormones, just a whole bunch of stuff. And a lot of these people, cholesterol, they come in and they're pretty sick. Like your average person on paper, on their blood work does not look good. And I start them on these GLP ones and I start, you know, you titrate with it, you start slow.And within several weeks, it's almost like a shot of fasting, if that makes sense. In the beginning, they will have some side effects, but they'll be really, really tired because their bodies aren't metabolically flexible. And so, and they'll get headaches too, just like I did in the beginning of fasting. But once their body starts to become more metabolically flexible and starts using this fat for fuel, then they start having extra energy. And they're not, they don't have that food noise. They have that appetite correction. So I see a lot of parallels to fasting with it. And then when we do some follow -up blood work, their cholesterol is better, their inflammation is better. They're just across the board. The things that made them unhealthy before, they are just so much healthier. And they just, you kind of just see like life come back in their eyes as well. And then what I do, so now some people need to be on them long -term, certainly.Some people don't need to be on them long -term. They just needed something to kind of like that restart button, the, have you tried unplugging it and plugging it back in? That's kind of what this medication does. And once they get to the weight loss and on average, I would say two pounds per week on average, some weeks that might look like one pound, other weeks that might look like three pounds. But when they get to where they want to go and they want to come off, I taper them off and I transition them into fasting because they're already kind of doing it. And they've spent these months building up this routine, kind of sort of like pressing the easy button because they weren't hungry. So they've built this schedule. They've built this routine. And so as we taper off, I would get them to do fasting, whichever windows would work well for them and just let them know if you go back to eating how you did prior to this medication, you're gonna end up with the body you had prior.But if we implement these changes and you stick to it, then you'll be able to maintain this. And I, my patients were very, very successful. And of course I just push the, you have to prioritize protein and you have to move, you have to exercise. And if that exercising is, you know, just putting on some ankle weights and going on a walk, you know, you have to do something. You can't just sit back because you want to lose fat. You don't want to lose muscle. And I did, because I had an in -body, I could really kind of take a good look at are they maintaining their muscle? Are they losing their fat? So I had some metrics to go by, but overall I'm a fan. It's not for everybody. It's not, but it is for a lot of people. And they have more and more studies coming out saying, you know, not only does it help with your blood sugar, but it's reducing the risk of cardiovascular disease. And now they're saying that it's reducing the risk of Alzheimer's and dementia. And so it's just exciting.

Melanie Avalon:
I love hearing this in particular because I think a lot of people are and I'll put a link in the show notes, you mentioned earlier that you used a fasting app. I don't know if it was the zero app or not. Yes, that was it. I interviewed recently Dr. Naomi, who is now she's one of the head people at zero. She's a doctor and she has like a weight loss. I think she works at a weight loss clinic. But we dived really deep into the science of GLP ones, you know, there's all this concern about muscle loss, which I think is so important and is happening to a lot of people. And I also wonder at the same time if people were to approach them and use them in a smart way and focus on protein and focus on maintaining muscle and staying active. Like you were saying, I just feel like, you know, that's a different case.

Amy Wrenn:
It is. And I've seen it. I've seen it 100 times. You can be on those and build muscle. You just have to put in the work, and you have to eat the protein.

Melanie Avalon:
And I've also wondered, and you literally said it, I've wondered maybe if people can be on them and then go off and transition into a fasting approach with a high protein diet, maybe that's the way to as much as possible sustain the results.

Amy Wrenn:
I did it with all my patients and the patients who adhered to that plan had lasting results. And even sometimes would come back and be even less body fat percentage than they were going like when they stopped the medication. Yeah, really incredible results.

Melanie Avalon:
results. Wow. Do you see people in Orlando or do you do online?

Amy Wrenn:
I'm actually not seeing patients right at the moment. I was in the clinic that I was at, they sold it, and I didn't agree with maybe the direction of the new owners because I'm very passionate and I have, I mean, nurse practitioners are nurses first and we just, we've put our patients first and I'm always going to put what I feel like is best for my patients first. So I am actually right now in a really cool position where I'm with a friend of mine and we've created or they've created, brought me on to help create this company that's called Advanced Practitioners Network and I'm doing clinical education for it. So I'm helping teach other doctors, other nurse practitioners about bioidentical hormone therapy, also peptides and GLP ones. So I feel like I have a broader reach now because we work with different clinics in almost all the different states and doing education and teaching them how to do these things appropriately.So it's been very, very rewarding for me, which is how when I won the key on and I told you I got to do that lecture on fasting that day, I was very excited about it.

Melanie Avalon:
Oh, yes, yes, that's how we yeah, isn't I think that's when I was like, Oh, you should come on the show. Yes, yes. Yes. Can you tell listeners briefly what lecture you did?

Amy Wrenn:
I did a lecture on fasting. Gosh, it was on just regular fasting, intermittent fasting, went a little bit into the fasting mimicking diet. It was for a bunch of doctors and practitioners, so it got a little sciency with the mTOR pathways and all that. It was kind of hard for me because I actually didn't create the presentation. It was created by one of my mentors, Dr. Louis Martinez, and he gave it to me and was like, hey, will you do this presentation? I was like, yes. Even though I know a lot about fasting and learning, somebody else's presentation is kind of hard. He had specific studies and specific diagrams, but it was very exciting for me. It was the first time I had been a speaker at a conference, so that was exciting too.

Melanie Avalon:
Cool, and congrats on that. Yeah, that's amazing. And thank you for doing that, talking about fasting and everything. It's really, really motivating and inspiring to hear people like you doing what you're doing. Because honestly, that's the way to really reach people in a very, very practical way. So it's so nice that you're doing that, and especially the education piece. Oh my goodness.

Amy Wrenn:
I'm loving it. We're actually writing a book right now too. I never thought... There's all these things that I'm doing that I never thought I'd be doing and it's very exciting. But yeah, we are... Dr. Martinez and I are writing a book on biogenical hormone therapy.

Melanie Avalon:
Oh, cool. Well, when you finish it, you guys should come back on the show.

Amy Wrenn:
Oh, fun, yes!

Melanie Avalon:
I would love that. Awesome. Well, is there anything else about your fasting journey that you would like to share with listeners? Any advice or tips or tricks or takeaways?

Amy Wrenn:
Because I think the biggest thing in the beginning is you just have to give it time and know that things are happening on the inside. And like I said, I had more than just weight loss. I obviously, at that time, I had a lot of inflammation that I didn't know about and that was presenting itself as in joint pain, acne rosacea on my face, and then also the weight gain. And so with time and with just trusting the process, I was able to reverse that inflammation. My skin got better, my joints got better, and then I had improved energy. And then, you know, aesthetically, I was able to lose the weight and get back into my clothes and then eventually need smaller clothes. So I think just giving it the time and using the things that are available to you, such as that Xero app, I just kind of liked clocking in and clocking out of my eating window and things like the San Pellegrino and a wine glass to make you feel like you're having your drink.Those kind of tools really helped me along. And then, I'm not really sure who said it. And I don't know where I picked it up, but somebody along the way, you know, said about increasing your steps. And I use that with my patients a lot because there are some people who are like, absolutely no, don't tell me to exercise. But almost everybody's phone, people have their phones on them if they don't have any kind of tracking device. If you look at it and you're getting 4,000 steps a day, try to get 5,000, just any little thing that you can do. And you kind of do that too with your iron pans that you work with. And I know you do the ankle weights and they make a difference, I swear. I believe you. I believe you. So just making those little changes, habits, and then it just becomes part of your routine. And then you can just kind of keep tweaking those things. You don't have to bite off big giant things. Just take these baby steps until they're part of your routine and then you can take another baby step.And next thing you know, you've gone a long way. What is that saying? Like, how do you eat an elephant one bite at a time? Something like that. It's the same kind of thing. So and then and then also the other thing, just know when you first start and you break your fast and you eat every single thing in your kitchen, that is temporary. It's going to get better. You'll have appetite correction. It will blow your mind.

Melanie Avalon:
your mind. That was so amazing and so helpful. I love that. Yeah, there's a, there's a lot of magic to just adjusting the little things that you do every day in little ways. It doesn't have to be this big, huge, concentrated, you know, starting this crazy gym practice and going, I mean, do that if you want, but there's like, you can make so much progress with all these little changes.

Amy Wrenn:
Yeah, do things that are sustainable.

Melanie Avalon:
Yeah, exactly.

Amy Wrenn:
Oh my goodness. Well, this was so fun. I really enjoyed it. Thank you.

Melanie Avalon:
so much. And we'll put pictures in the show notes, but you look amazing. You're glowing. Beautiful. Yeah. Thank you so much for sharing everything and everything that you're doing and being here with us on the show. Hopefully we get to meet in real life sometime.

Amy Wrenn:
really hope so. I really do. I think it's going to happen. Like I said, I feel like I've been manifesting this for several years now.

Melanie Avalon:
I am going to by the time this airs, it will have happened, but it's kind of closer to you. I'm going to eudaimonia. Have you heard of that conference? No, where's that? It's in West Palm Beach and like everybody is there. I'm gonna meet Cynthia Thurlow in person. We've never met.

Amy Wrenn:
I'm so excited. Okay, what month is it in?

Melanie Avalon:
November 1st through 3rd, Dave speaking, Huberman is speaking.

Amy Wrenn:
Oh no, I think I did see that. I love her. Thank you for turning me on to her. I'm obsessed.

Melanie Avalon:
I love her too. Like literally so many guests I've had on my show are going to be speakers. So you should go.

Amy Wrenn:
I need to get my son is at school over there at in Boca Raton at FAU, so I should make it a weekend.

Melanie Avalon:
Yeah, you should. If you do, totally let me know because I will be there. I will. I'm going to go the first two days. And again, when this airs, it'll be in the past. But so hopefully we got to meet. That'll be exciting. But thank you so much, Amy. This was absolutely amazing. Congrats on everything you've accomplished and are doing. And yeah, just keep on keep on keeping on. This was awesome. This was. Thank you so much. Awesome. You too. I will talk to you in the future. OK, talk to you soon. Bye. Bye.

Melanie Avalon:
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by Podcast Doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Vanessa: ketogenicgirl.com

Original theme composed by Leland Cox and recomposed by Steve Saunders.

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts - it helps more than you know! 

 

 

Oct 27

Episode 393: Breakfast Meals, Hashimotos & Thyroid Issues, Autoimmune Conditions, Breastfeeding Mothers Who Fast, Oatmeal & Gluten, Optimal Health & Nutrition, And More!

Intermittent Fasting

Welcome to Episode 393 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Vanessa Spina, author of Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

BUTCHERBOX: Grass-fed beef, organic chicken, heritage pork, wild-caught seafood, nutrient-rich, raised sustainably the way nature intended, and shipped straight to your door! For a limited time go to butcherbox.com/ifpodcast and receive your choice between a whole turkey, turkey breast or spiral ham in your first box. Plus, get $20 off your first order!

To submit your own questions, email questions@ifpodcast.com, or submit your questions here!! 

SHOW NOTES

BUTCHERBOX: For a limited time go to butcherbox.com/ifpodcast and receive your choice between a whole turkey, turkey breast or spiral ham in your first box. Plus, get $20 off your first order!

Listener Q&A: Kenna - Hashimoto's and thyroid issues with intermittent fasting. Good idea? Bad idea?

Episode 374: Autoimmune conditions, Rheumatoid Arthritis, Inflammation, C-Reactive Protein, Plant Based Diets, Fasting Styles, And More!

Listener Q&A: Rachael - I would love to hear Vanessa's take on breastfeeding and IF/keto

Listener Q&A: Jann B - Who do we believe [about nutrition] and what do we eat for optimal health?

Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.

TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.) 

Melanie Avalon:
Welcome to Episode 393 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of "What, When, Wine" and creator of the supplement line AvalonX. And I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of "Keto Essentials" and creator of the Tone Breath Ketone Analyzer and Tone Lux Red Light Therapy Panels. For more on us, check out ifpodcast.com, melanieavalon.com, and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Melanie Avalon:
Hi, everybody, and welcome. This is Episode number 393 of the Intermittent Fasting Podcast. I'm Melanie Avalon, and I'm here with Vanessa Spina. Hi, everybody. What is new in your life, Vanessa?

Vanessa Spina:
Everything is great. Things are going really well. How are things with you? They're good.

Melanie Avalon:
this episode actually airs a few days before Halloween. I won't talk about it too long, but I'm really excited because, are you a Wicked fan? I think you mentioned it recently. I probably mentioned it because I saw Dina Menzel. Yes, that's what it was. Well, related but unrelated, my sister and I decided last night that we're gonna be Alpha Bunclinda for Halloween. So cute.

Vanessa Spina:
I love how you plan your costumes.

Melanie Avalon:
Oh, I literally already started ordering the costume.

Vanessa Spina:
And what are you going to do for Halloween?

Melanie Avalon:
go out? I don't know. Normally, we've been going to like the aquarium. We'll have events. Oh, yeah. Yeah. Yeah. You went to a gala or something there, right? Yeah. They have like a sips under the sea where you like drink and look at the fishes. Yeah. I'm all about the Halloween parties. Here's a random thing I wanted to share though. I was reading this random article online and I know we talk about this a lot, but I don't think I realized the history of this. Do you know where the phrase breakfast is the most important meal of the day comes from? Kellogg's maybe. Yes. It was a marketing slogan in 1917. Isn't that upsetting? I don't know how I didn't realize that it literally was a marketing slogan.

Vanessa Spina:
Kellogg's is like one of the most disturbing stories that a lot of people don't know about too. Maybe more people know about it now. It's very bizarre.

Melanie Avalon:
So this says the founder, John Harvey Kellogg, was a physician and seventh-day Adventist and he strongly believed in the connection between healthy eating and religious morality. His idea was that creating a simple bland food like cornflakes would encourage abstinence from sex and a clean, pure lifestyle. He pushed the slogan to encourage more people to eat a plain cereal breakfast to support these values.

Vanessa Spina:
Yeah, it's so weird. Like they wanted people to suppress their carnal impulses and stay away from meat, which is, you know, makes you more carnal. It's the root word carne. Oh, wow. I never realized that like carne asada. Mm hmm. And they wanted people to eat these like sad dried flakes to make them I love that they're sad. They are right? Literally standard American diet, high carb. It's such a weird story. It's such a weird story. And then, I mean, I have nothing against people who believe in, you know, that religious sector or anything. But I think the origin of it, there was like a young woman who had these like visions where she was told that we should be vegan. And that's kind of why Seventh Day Adventists are vegan. And, you know, Dr. Ted Naaman was one who was like brought up in the Seventh Day Adventist. I don't know what you call it, sect or the theology of Seventh Day Adventist, or I'm not sure how you refer to it. And, you know, he's, he's such a big, you know, protein advocate and proponent because he saw the effects that it had on his body composition. It's really interesting. But yeah, it's, it's, it's so bizarre. When I first heard about it, I was like, there's no way that could be true. Like if you really read the whole story, I interviewed this vegan influencer. He was like a fit fitness model, John Venus. And he was really big fitness. He was a really big fitness influencer who was vegan. And then he decided to basically like start eating meat again. I did this really interesting interview with him because we talked in depth about it. And I had all these like, you know, images in the video interview, showing some of the stuff like the roots of Seventh Day Adventism and veganism and all that stuff. And like, people are just like, what? Like, how is this real? Anyway, I'm not surprised that it's Kellogg's.

Melanie Avalon:
It's interesting because apply that logic, especially because with intermittent fasting, a lot of people's concerns is that breakfast is the most important meal of the day. We feel like that comes from science. I know there have been a lot of studies on breakfast eaters, but I've done a deep dive into that and I find the studies a little bit nuanced and a lot of them are funded by breakfast cereal industries. A lot of them are lifestyle because we've been told for so long that breakfast is the most important meal of the day, that there's the healthy user bias. People who are following healthy habits often tend to eat breakfast because they're following the healthy habit lifestyle that we've been prescribed and told about. Think about it about something else. Think if there was something like, I don't know, drink more water. What if you found out that that came from, which it didn't, but what if you found out that that came from like Aquafina or Dasani? You would be a little bit skeptical about it. To hear that breakfast is the most important meal of the day or if you heard that like an apple a day keeps a doctor away came from, I don't know, if there was some apple company. So to know that this idea that's been so saturated in our culture came from a cereal company, I mean that alone is an issue, but then on top of that, a cereal company that was trying to change people's morality with their cereal, it's just, I don't know, it's very disturbing and it makes it really hard to take breakfast as the most important meal of the day seriously, as a phrase.

Vanessa Spina:
You know, I've kind of reframed it in my head because there is really interesting research that the first meal that you have in the day, if it is a protein-rich breakfast, that that gives superior blood glucose control for up to 24 to 48 hours following, I think it's at least 24 hours. So I tend to think of whichever meal you break your fast is, is your break fast. And so it is quite important. I do agree with it because I think it can also set the tone for the day in terms of your blood glucose control. So having protein at that meal I think is really important, which cornflakes, flakes of corn are pretty scant in. So if people are going to have some flakes of corn, I would like for them to add protein powder into it. My mom likes cornflakes in the morning, and so she puts my protein powder in it. And my dad likes to have muesli, and he puts my protein powder in it now. So I'm really happy about that because I think, you know, just having protein at that first meal is so helpful, you know, to halt muscle protein breakdown, which is, you know, quite high throughout the night and up until you have your first meal. So I do believe it is probably the most important meal of the day. But if you have OMAD, it's also a break fast or breakfast, right? Exactly.

Melanie Avalon:
I could not agree more. I'm so glad you brought that up. It is literally break fast. But breaking it with something, you know, we just talked about this, but literally, you know, the Kellogg's are like this, those cereals were created to make people lackluster in their energy. Like literally the point was to tame down people's vitality.

Vanessa Spina:
Yeah, it's great.

Melanie Avalon:
Crazy. So it's just something to let marinate. Yeah, I have my breakfast every night at late. Very, very late. I'm also really intrigued. It's really interesting to think about, like it could have gone so many different ways. I find it really interesting that what culturally certain foods became quote breakfast foods and not other foods. Like I find it really interesting, you know, why are eggs, why are they a breakfast food and not a dinner food? And why is that is interesting. Why is chicken a lunch and dinner food and not a breakfast food? Like why?

Vanessa Spina:
Yeah, I could have eggs at any meal of the day and actually often add them to my dinner if I'm having a burger because they're so nutrient dense and I don't always have them for breakfast. But yeah, it's like, why are they a breakfast food? There must be, I'm sure there's a reason.

Melanie Avalon:
No, I'm sure there is, or like, and you would think like, oh, maybe it's like the time required, but like pancakes, that requires a lot of time to make that. So why are pancakes breakfast and not dinner? Yeah, because I can see eggs, like eggs are easy. Like you just crack them in. So maybe they're easy for breakfast, but the logic doesn't follow.

Vanessa Spina:
Yeah, I like to eat breakfast foods for dinner sometimes. I'll make waffles. I'll make protein waffles. I'll have eggs anytime of day, but yeah, it is really funny and interesting what made those foods. Have you had other eggs?

Melanie Avalon:
like goose eggs.

Vanessa Spina:
No, but duck eggs. I used to recommend duck eggs to people if they had issues with eggs, because there's a crazy amount of people have issues with eggs. And I didn't realize it until years ago, I was doing my meal plans and programs. And I had a few thousand people were doing my programs. And so many people would be like, do you have an egg alternative? It was a huge amount of people. Like I thought most people could tolerate eggs, except for like, like my aunt, she couldn't eat egg whites. I thought if anything, sometimes people have issues with the egg whites, so they can still have the yolks. And you can actually make plenty of egg dishes just with the yolks. But it really astounded me how many people have egg intolerances or they just can't eat eggs at all.

Melanie Avalon:
Hmm. Yeah, it's interesting. It makes sense when you think about it because the egg, it needs its own protection. So it makes sense that the immune system would be reacting to it for some people. Yeah, it's really interesting. I do like eggs. Well, anything else new or shall we jump into some questions? Yeah, ready to jump in. All right. Would you like to read the question from Kenna? It's.

Vanessa Spina:
Sure, so Kenna asks, Hashimoto's and thyroid issues with intermittent fasting. Good idea, bad idea?

Melanie Avalon:
All right, Kenna, thank you for your question. I did a deep, deep dive into this. So I know her question is about Hashimoto's specifically, and that is an autoimmune thyroid condition. But I wanted to look at the whole picture. So basically, how does fasting affect the thyroid in general? And then how might fasting affect Hashimoto's? So I tried to find every study I could find looking at fasting in the thyroid. And I'm just going to go through them, because I think it will provide a good picture of how the results, there's not one answer for how it seems to affect the thyroid. So I think you'll get a good idea if I go through a few of them. So for example, there was one study called Randomized Controlled Trial for Time-Restricted Eating in Overweight and Obese Young Adults. That was an August 2022 article. It looked at a six-hour eating window in overweight and obese young adults, and it found no significant difference in free T3. You know what, before I do this, let me give a really quick brief overview of the hormones, so this will make sense. So the main ones that I'm going to be talking about are T4 and free T4. So that is the storage form of your thyroid hormone. It gets converted in your body to T3, which is the active form. So the actual feeling you have of, like, is your thyroid working correctly? Like, is the metabolism going? That's the feeling of T3, because that's the active form. But it's dependent on T4, because that's the storage form that converts into it. TSH is what the doctors often look at to determine your thyroid status. TSH is actually not a thyroid hormone or signaling thing. It's actually related to the pituitary. And it is how the brain is feeling about thyroid levels, like, are they too low? Are they too high? And then the TSH is a signaling that tells the thyroid to make more or less hormone. So when doctors look at TSH, if it's higher, it means that your brain is perceiving that you are low in thyroid, because it's saying, we need more. So it's like sending TSH signals. If the TSH is lower, it's like the brain is saying, we have enough thyroid hormone. You know, make less. So that's what's going on there. The irony about it is when you get a standard thyroid panel, the doctor will usually just look at TSH and T4. So basically, they're looking at TSH, which is how your brain is interpreting things. It's not actually what actually might be going on. And then T4, which isn't even the active form. So there's so much room for false, just false interpretations of what's happening, because your signaling could be going, but it's not actually landing, like, you know, the thyroid's not responding appropriately. The pituitary could just be off in the TSH. I don't know how common that is. But then T4 is the storage form. So it doesn't even speak to the active thyroid hormone that you have. So with that caveat, let us look at these trials. There was that one I talked about that I just mentioned, the randomized controlled trial for time restricted eating and overweight and obese young adults. It looked at a six hour eating group. It found that the fasting, so with a six hour eating, decreased, did reduce the TSH. But there was no significant difference in free T3 or free T4. So basically, the actual thyroid hormones did not change, but the TSH went down. So the metabolism was not changing at all. But the pituitary, so the brain was like, let's maybe make a little less thyroid, even though it didn't manifest that way. They also mentioned as well, what's interesting is that low levels of TSH and thyroid hormones without an impaired thyroid gland have been related to longevity. So the takeaway here was that this possibly could have longevity boosting benefits. And there was no actual change in the metabolic rate, at least in that study. So that's one. There was one called alternate day fasting improves physiological and molecular markers of aging in healthy non obese adults. This one looked at alternate day fasting, and it found that there was no chance, this is ironic because it's literally the opposite of what the other one found. This one found the TSH did not change, but the T3 did go down a little bit. That said, there was no changes in resting energy expenditure. So that's a little bit mind blowing. Basically the thyroid, the active thyroid hormone T3 went down a little bit, but they resting metabolic rate didn't change, which seems like a paradox, but that's what they found. And they also commented as well that this might be slowing of the aging process because the reduced T3 is actually related to longevity. They also found no difference in T4, which is interesting. Yeah, and then to comment just again on the metabolism change, they said, we did not detect changes in resting energy expenditure after ADF, neither in the randomized control trial nor in the long-term fasteners. Then there was another study called effects of intermittent fasting on the circulating levels and circadian rhythms of hormones. This was 2021. This actually was a review of studies of the findings, and they found in general that fasting can cause T3 and stem studies to go down rapidly with fasting up to 55% after 24 hours, but that while it goes down, the TSH remains the same. So that's similar to one of the studies we read before and not the other. They also found that short-term, four-week and long-term more than six months ADF diets, alternative fasting diets also seem to reduce circulating T3 without changing TSH. And that was also found as well for a study in an eight-hour time-restricted eating window. So again, T3 going down, TSH not changing. And they did suggest that if people are on thyroid medication, which I want to talk about another study that talks about that, they might need to really monitor their medication because of how their TSH might change. What's interesting about that, because I actually read the study that it was referencing, and that study was called effect of Ramadan fasting on thyroid functions and hypothyroid patients taking levothyroxine, a systemic review of meta-analysis. So this is people who are doing Ramadan fasting and they're on thyroid medication, which everything, all the other studies that I was talking about were presumably people not on thyroid medication. It was just fasting. They found for these patients that there was no change in free T4, but the TSH did go up for those taking medication specifically, but it didn't go out of range. So their takeaway was that there might be something, you might need to pay a little bit more attention if you're on thyroid medication while fasting because of how it might affect the TSH and you might need to change your dosage. Although I just, I don't know, I don't know if I agree with that because I would definitely work with a doctor and get a full panel. I just find it interesting that if your TSH is changing, but your actual levels aren't changing, I don't know if I would personally adjust the medication if the levels aren't changing. This is something where I'm not a doctor. I would really suggest that people work with a knowledgeable practitioner who runs a full thyroid panel to monitor your thyroid. A full thyroid panel is going to include TSH, T4, free T4, T3, free T3, and possibly reverse T3, which is a hormone that can actually block T3. So you can have active T3, like active thyroid hormones, but if you have high reverse T3, it can actually be blocking that action. So that can explain seemingly hypothyroid symptoms with normal T3 levels, for example. So my takeaway from all of those studies looking at fasting's effects on the thyroid function was that some of the studies find that the TSH changes, but the thyroid hormones don't. Some of the studies find that the thyroid hormones change, but the TSH doesn't. And some of them find that they both go down a little bit, but multiple studies did note that TSH or the thyroid hormones going down, if there's no actual problematic change with the thyroid itself, that that is linked to longevity. So I'm going to talk about Hashimoto's, but basically my thought on that aspect is none of these studies found, none of these studies that I looked at found that fasting created a really problematic state for the thyroid. So I think it's really wise to monitor thyroid status, especially if it's something that you struggle with historically while fasting, but I definitely wouldn't be overwhelmingly concerned. That said, there's a difference between fasting while eating and nourishing diet with plenty of protein and over fasting and over restricting what you're eating and just, you know, doing too much. And I think that's a completely different scenario. So that's not what I'm speaking to. As for Hashimoto's, so there was one study called intermittent fasting, a promising dietary intervention for autoimmune diseases that is a September, 2023 study. It talked about how intermittent fasting can have beneficial effects on various autoimmune diseases. And the reason I'm talking about this, because as mentioned, Hashimoto's is an autoimmune condition. It did note however, and it gave a lot of mechanisms for why that might be. And we actually talked about this on a recent episode. So I will put a link to that episode in the show notes where we did a deep dive into intermittent fasting for autoimmune conditions, but they did note that the majority of those diseases that our studies have shown fasting is helpful for are things like diabetes and arthritis. And some of those mechanisms are improving the gut microbiome, enhancing cellular repair mechanisms through autophagy. They said that more studies are needed, that they're limited and conclusive on thyroid diseases in particular. That said, there's a lot of reasons that fasting could potentially have a, there's a lot of mechanistic reasons for how fasting could potentially have a beneficial effect on Hashimoto's just by reducing inflammation in your body in general. So I just mentioned it briefly, but the fasting can have a really beneficial effect on the gut microbiome. And there's a lot of studies showing connections between the gut microbiome and your thyroid and oxidative stress. So free radicals can cause a lot of damage in the body and are really linked to autoimmune conditions. The fasting has been shown to reduce that. Lowering inflammatory biomarkers in general. So people with autoimmune issues tend to have high levels of inflammatory biomarkers. And we have studies showing that fasting can reduce these biomarkers indicating inflammation in the body. So my thoughts on this, I think from just a autoimmune perspective for Hashimoto's, I think fasting could probably be very beneficial for that aspect. And then for the actual thyroid functioning issue, like I said, the study, the literature seems to indicate that you might see a slight drop in T3, maybe a little bit of change in your TSH. But in general, that's probably a good thing, probably linked to longevity. All of that said, definitely work with a doctor, definitely make sure you're not over restricting. That's all my thoughts. Do you have thoughts on thyroid stuff, Vanessa?

Vanessa Spina:
That was so comprehensive and amazing. I mean, you went through all the different, you know, labs and hormones and then all the studies a few of them I had looked at as well and thought it was interesting that there were some different findings. The one that I found the most interesting was a review that talked about how T3 levels can drop quite a bit in the first 24 hours of fasting, but they tend to normalize afterwards. So sometimes there may be like a large drop initially, but it might not be something that will last. A lot of the studies also talked about how the levels usually go back to what they were right after people stop fasting, but I completely agree with you. It's definitely something to consult with your practitioner care provider about, especially because there are complications like medication levels and things that might be affected and might change. So thank you for doing that amazing summary on all of the research out there.

Melanie Avalon:
No, of course. And thank you because I totally saw that as well and I completely forgot. So I'm so glad you you saw that. That's perfect. Yeah, I did see that about the T3. It seems to rebound pretty quickly right after. So I've been haunted for quite a while by the the metabolism, body temperature, thyroid levels and longevity question. It bothers me because on the one hand, you know, there's people, you know, it kind of I guess it relates to calorie restriction as well with with longevity because, you know, we know and we talked about this actually last episode, but calorie restriction in general has been the one dietary intervention to really show a boost in longevity across lifespans. And it does seem to have a, you know, reduced body temperature, probably reduced metabolism. And so there's this whole like question of, you know, where should the metabolism actually land for the ultimate both longevity and health span as well. So it's really intriguing to me. Shall we do another question? Yes, sounds great. Okay, so this is a question for Vanessa. Rachel wants to know, she says, I would love to hear Vanessa's take on breastfeeding and if/keto and you are breastfeeding currently correct.

Vanessa Spina:
Yes, I'm hoping to also get to two years. I did with Luca. So I did breastfeed with Luca successfully doing intermittent fasting and keto, although my approach with keto is modified keto. So I do high protein keto, not the traditional ketogenic approach, which is, you know, restricted, moderated protein. I eat closer to one gram of pound, one gram of protein per pound of body weight, or 2 .2 grams per kilogram per day. And so for some people, this would kick them out of ketosis. I tend to get back into ketosis with the intermittent fasting. And the fact that I also do a lot of activity and movement breastfeeding probably adds to it as well, because the calorie burn, I think breastfeeding for me, I felt way hungrier than I ever did when I was pregnant. And I've heard a lot of women tell me this. Yeah, like you, it's just, it's amazing because you're like growing a baby, you think you would be ravenous, but some people actually have no appetite or even get nauseous, you know, in, in really, really challenging situations, like with hyper amesis, you know, being nauseous, like every day, all day, no matter what you eat, or if you don't eat, it's just horrible. I can't imagine how difficult that is. I really don't like being nauseous. I didn't have any nausea during either of my pregnancies. I'm so, so thankful for cause I just am such a baby when it comes to nausea. I did that, but I was also doing intermittent fasting and high protein keto during our conception period, during pregnancy during. So for me, it wasn't like a big change. So I think the question comes up a lot where people, you know, have been doing a different approach and then postpartum, they're, they're like, maybe I should, you know, start intermittent fasting/keto or get back into it. And so I would say for me, I waited at least six months to make any changes because if you make changes like intermittent fasting or keto, you might go lower in calories that could definitely affect supply. I don't think lack of carb affects supply as much as people think it does. Personally, I think it's more related to calories. And if you're eating enough calories to sustain what your body needs, plus breastfeeding, I don't think it really matters whether or not you're eating any carbs, your body makes carbs, it makes glucose with gluconeogenesis. It's more about how much energy you're taking in. And it doesn't really matter if you're getting the energy from carbs, all carbs, or no carbs or all fat or some fat or a mix of both with protein, because you can also oxidize some of that as well for fuel. So I just waited until about six months to make any changes, because that's when Damien started eating solid foods. So if anything affected my supply at that point. then I would be, it would be okay because he would be eating solid foods at that point. My supply was not affected by the changes that I made. And for me, I started adding in more carbs and eating a little bit less fat. So I started playing up with my macros a little bit and then changing up meal timing and stuff. So that's what I did in terms of changes and also doing more exercise, doing more movement, more workouts, just to feel a little bit more like my pre baby, even though pre baby self, even though like I've mentioned before, I didn't gain weight during my second pregnancy, but I just felt like my body composition was a little bit different. So I think, you know, something you can talk about, you know, with your doula or someone you, you know, work with in terms of, of how you're doing with your recovery as well. You know, how you're feeling energetically, just because the, the concern is that with intermittent fasting, keto, you might under fuel. And I think that's one of the big risks with breastfeeding or not risks, but the times in people's lives when they can under fuel, because you don't realize how many calories you need when you're breastfeeding. Like I had a friend, Caitlin grass fed girl, she told me she was waking up in the night and having to eat when she was breastfeeding. She was so ravenous. It's the, yeah, by far the hungriest I felt was when I, I started breastfeeding both times with, with Luca and with Damien. So it's really a time when you can under fuel, like I keep mentioning. So yeah, that's the, those are some of my thoughts on it. And I've done research on supply and carb content. You know, it's definitely something that people can play around with, but it does change the milk composition somewhat. But in general, I think supply is really much more tied to actual calories than, than carb or fat, if that makes sense.

Melanie Avalon:
Yeah, no, it totally does. I have no comments. I know nothing about this. So thank you for sharing your experience.

Vanessa Spina:
Yeah, thank you for the question. It's always fun to talk about this stuff.

Melanie Avalon:
So, like, when you stop breastfeeding, do your hunger levels return to normal pretty quickly or do you remember from your last time around?

Vanessa Spina:
I think it's just like, I don't feel as hungry now as I did like eight months ago, Damien's... Well, when this podcast comes out, he's going to be about 10 months, but right now he's about eight months and he... I am not as hungry as I was like when I started breastfeeding. It's always like at first, there's like a big adjustment. And I think because the body is recovering so much as well, you just... Also, you don't eat a lot during like the days leading up to the birth. There's usually other things happening. So you get like really, really hungry usually, right when it starts and your milk comes in, but it does tend to level up. After a while, like I don't feel ravenous all the time, but there may be some connection there to why I've been playing around with more meals, adding in a third meal, which sadly... So I've been playing around with oatmeal and protein. And I've been doing that as a first, first meal to do three meals a day. And I think I'm having some kind of reaction to the oatmeal because of my gluten sensitivity. So I think I've actually... I had to cut it out the last three days because it wasn't spiking my blood sugar at all. My other meals, like my yogurt meal, spikes my blood sugar more than oatmeal. And I always avoided oatmeal because I thought it would really spike my blood sugar, but it raises it about as much as coffee does, which is not that much. So I was kind of enjoying trying something different and doing... Like I put my protein powder in the oatmeal and having that in the morning with the kids, but I'm getting like a lot of muscle stiffness, which I never normally have. I was reading that there's a protein in oatmeal called like Avenin or Avenin, Avenin maybe. And it's similar to gluten. I read some blogs and they said, you can try just pure gluten-free oats because sometimes there's cross-contamination that could be causing it. So I got some gluten-free oats and some sprouted oats. And I'm taking maybe like a week or two off now to see if that's the connection. So I'm actually hoping that's what it is because I never have any muscle soreness. And yeah, I don't like having muscle pain. So I'm like, I don't think it's my workouts. I think it could just be this. And it's funny when you eat the same things all the time. Like you can tell if you try something new and your body reacts in a certain way, you can pretty much pinpoint it right away. Anyway, that's off topic.

Melanie Avalon:
No, I love it. Honestly, one of the more mind-blowing experiences at paradigm shifts is, you know, if you've been eating just, you know, whatever, like our standard American diet, and then you do clean up your diet, that it's fascinating in a way how you can tell how things affect you. I just remember thinking like, wow, I can't believe I was eating this stuff all the time. And I didn't realize, but it was just being in a state of chronic inflammation versus removing that inflammation, and then you can actually notice it from what you're reacting to. So thanks for taking one for the team with the child bearing. I'm so grateful to women like you for, you know, raising awesome kids.

Vanessa Spina:
Thanks, it's yeah, it's wonderful. It's wonderful. We love it so much.

Melanie Avalon:
Awesome, awesome. All right, shall we answer Jan's question?

Vanessa Spina:
Yes, I will read it. So Jan says, I believe that food is a source of good health. What we eat truly makes a difference. However, if you watch YouTube and listen to podcasts, you will hear a dozen different opinions on what we should eat. I think we can all agree that ultra-processed foods are bad for you. But beyond that, what? If you listen to Dr. Berry and many others, you know they believe eating carnivore is the proper human diet. But if you listen to Dr. Barnard and many others, you know they believe eating whole foods plant-based is the only way you should eat. Yet many others believe keto is best. Some say intermittent fast every day. Some say don't intermittent fast, it's bad for you. Also oil, again, we can agree that seed oils are probably bad for us. What about olive oil? Some say olive oil is great for you. Some say olive oil should not be eaten. And what about protein? Who decided that women should have 30 grams of protein per meal or at least 100 grams a day? Did they just pull this number out of the air? Where did they come up with this number and how did they know? So who do we believe and what do we eat for optimal health?

Melanie Avalon:
Okay, I'm having a moment, okay, because the way you pronounced it, now I'm just wondering, Doctor, I've always said Neil Barnard, and I'm just, the reason I'm like fixating is when I interviewed him, I'm like, did I say his name wrong? How did you say it, Barnard?

Vanessa Spina:
I was just reading it. I don't know this person, so Barnard. I just said Barnard because I'm reading it.

Melanie Avalon:
I really hope it's Bernard, because that's how I introduced him. I'm like, Oh, no, I'm like, gonna go listen after this and try to find a

Vanessa Spina:
podcasts where he introduces himself and then you'll know.

Melanie Avalon:
Yeah. Oh my goodness. Have you had that before where you have guests on and you can't find and like you can't find how to pronounce their name correctly? Or like I

Vanessa Spina:
Yeah, I had one, oh, Dr. John Jake Wish. He told me right before we started, he's like, you're going to say my name wrong. Write it down right now in front of you on a pad of paper. It's Jake Wish, like Jake had a wish. So I wrote it down and I was like, well, this is a lot. And then I started saying it and I was going to say Jack Wish. So I looked down and I was like, Jake Wish, thank you.

Melanie Avalon:
That sounds like something he would say.

Vanessa Spina:
Yeah, totally. And I'm so glad he told me because I was going to say Jake Wish.

Melanie Avalon:
That's so funny. I love that. Normally I'll ask like if they're not somebody super well known, I'll just ask them at the beginning how how to pronounce their name. But sometimes if it's somebody that I, you know, I should know then because I remember I remember I like Louise from key to gains visa nor. How do you say his last name? Villas in your okay. See, I literally I went down the rabbit hole. I was like listening to every podcast I could find and like everybody was saying it differently. I was like, I don't I can't I can't do this. And so then I think it before I was like, I am so sorry. Like I know who you are. I just I don't. How do you say your name? So okay, on that note, I love this question from Dan, I feel like it really captures the just the frustration and angst of one of the biggest issues we have today, which is so many opinions about what to eat and it can be very overwhelming and I feel you and it's honestly a big reason that I have my other show the Melanie Avalon biohacking podcast is because there's so many opinions and I've been seeking for so long. I've been haunted by this idea. I'm like, I want to follow the perfect diet. Well, spoiler. There's not a perfect diet. I don't think but a big reason I have that other show is because I just wanted to interview people of all different perspectives because you know, I just want to know and there are I Jan, you pointed out so many good examples of how there are completely different opinions on things, you know, all the carnivore people versus the vegan people and intermittent fasting and the seed oils and olive oil and olive oil is a good example because I feel like it's highly touted and it's like one of the ones that kind of and it infiltrates all sides with all sides having both opinions about it, which is super confusing. So like at least with like meat versus plants. It's like, okay, one side is like all meat and one side is all plants like olive oil. It's like this wonder food and like, you know, Dr. Gundry loves it. He's big in the cuto world and a lot of vegan people love it. But then you have like the low fat vegan to like avoid the oils and you'll read like when I read Marian Nestle's book. She has a lot of books about food politics that completely blew my mind about olive oil and the industry behind it and all the like olive oil funded galas where they invite doctors and it's all funded by all of oil companies and it's just, it's very confusing. What I would say is, and you mentioned this in the beginning of your question when you said we can all agree that ultra processed foods are bad for you. Even that there are people who will not agree like the repeat people. They actually love like refined sugar. So go figure. I think if you step back and just look historically, what were we eating? You can see that there's a commonality. And you mentioned it with ultra processed foods, but just focusing on real whole foods that we can eat that we don't react to Vanessa was talking about her experience with gluten sensitivities and things like that. That's a really great start and you can focus on what is the most nutritious thing I can put in my body that's in a whole foods form and try not to stress as much about all the opinions about it. Basically, I think we can be more intuitive than we give ourselves credit for if we're eating real whole foods. So like carnivore versus vegan, some people thrive on vegan. I do think it's less than the vegan culture makes it seem like. They'll make it seem like vegans the answer for everybody all the time. And I think most people I do think I can say this pretty, pretty confidently. It seems like a lot of people, if not most people who do vegan, it's not sustainable long term. And they do need to end up bringing in some sort of animal foods with carnivore similar story. A lot of people thrive on carnivore and do it long term. I think I don't know. I don't know if it's a most thing because maybe that's a more niche group of people. But I think a lot of carnivore people do end up bringing back some sort of plants back into the diet. So the body knows what it needs nutrition wise. If we listen to it, I think we can see all of this information that we received from all these different sources as helpful. It's kind of like when I interviewed Max Lugavere and I remember I asked him what his thoughts were because I think at that time I was also interviewing Michael Greger. And he pointed out, because Max is a big proponent of the importance of animal foods for brain health. And so I asked him his thoughts on Michael Greger, who's like very, very, very vegan. And he pointed out that he thinks one of the strengths of Dr. Greger is how he really draws attention to all these really wonderful health benefits of different plants. So maybe a reframe here is rather than thinking, oh, I can't eat this, this is bad. What are these different sides saying are foods that are very good and nourishing for us? And then what from that plate of foods makes you feel good? I'm just really about listening to your body. And this is a very simple statement, but I really think it is telling if there was one magical diet, I really think we would have found it by now. And it would work for everybody. So I think these blanket statements that everybody needs to be doing carnivore all the time, or everybody needs to be eating just plants all the time. I just fact checking that that seems a little bit difficult to make as a true absolute statement because it's not working for people all the time. And you could say maybe they're not actually doing it right. And but I don't know, I just think I think if there was one diet, we would have found it by now. I think we can all agree mostly that ultra processed foods are a major problem here. And just going back to the whole foods is a really, really great place to start. Like seed oils, for example, there's, yes, there's a lot of evidence that seed oils are highly problematic and inflammatory, especially when they're refined and high heat process. And so seed oils are things like canola, cotton seed, corn, soft flour, sesame, and sunflower. There's like three C's and three S's that you can remember. But even with that, people will add like, you know, whole pressed seed oils to their salad and you know, think it's maybe it is maybe it is great for them. That's another example where I just like to go back to what is the natural form? Like, can you go up for seed oil? Can you go up and eat seed oil from nature? Actually no, you have to have to like, get all these seeds and it's a very labor intensive process to extract the oil from those seeds compared to olive oil, which is a little bit easier with just pressing the olives and getting the oil out of it. So I think just taking a step back, trying to not have too much fear surrounding things and choosing the foods that will, that feel good in your body, I think that's the way to support optimal health. Would you like to talk about that/the protein, Vanessa?

Vanessa Spina:
Sure, yeah, and I didn't know there was controversy around olive oil. I thought we all agreed it was amazing, full of polyphenols, but just shouldn't be heated.

Melanie Avalon:
So I think the controversy that would come in would be, maybe it's more about, it's a few things, probably three things I'm thinking of. One, reading food politics by Marianne Nessel, and then also Nina Teichels talks about it as well in her book, The Big Fat Surprise. It just makes you a little bit, kind of like we were talking at the beginning of the show about breakfast is the most important meal of the day. When you realize the exuberant amount of funding and the olive oil industry, it just makes you a little bit suspicious of things. Beyond that, I think there's a lot of issues with olive oil fraud. Like it's so bad. Then you mentioned that a little bit, but like it's really bad to the point where I get just, you really, really want to bet the olive oil that you are, that you're having a lot of the olive oils on the shelf are actually cut with other oils. So they're not completely olive oil. And then there can also be the issue of things going rancid or cooking temperature creating issues. I think the third thing is, I just think there's some people will say like, pour olive oil on everything. I think Gundry is famous for... Yeah, I was thinking of him. He's like having it by the leader. He's taking shots of it. So there's that side. And then on the flip side, there's like the low fat approach. And people will say, don't add all these oils. Yeah. So I guess it's not like super controversial, but there's definitely different opinions on it. And it's just weird that it can be this magical thing that's like you just take shots of compared to some people saying minimize.

Vanessa Spina:
I wouldn't take shots of it, but I do, like if I'm going to make a salad dressing, I use olive oil. If I'm going to make something like a marinade, I usually use olive oil. I think it's amazing and yeah, has a lot of polyphenols in it, but I just make sure to get it in protected glass and make sure I'm sourcing it really well. But I think it is, like you said, I mean, we go to Greece a lot and they make it there just from the olive trees, like fresh olive, fresh pressed olive oil, and it's been consumed for so many years, for thousands of years by, especially in the Mediterranean, which has a lot of centenarians and all that. But with the protein, I love this question. So the 30 grams of protein per meal, or at least 100 grams a day, this is not out of the air. This is actually research done specifically in the lab of Dr. Don Lehman, and Dr. Don Lehman was the mentor of Dr. Gabrielle Lyon, who worked in his lab for a time. So what Dr. Don Lehman discovered is that your body switches on this process of making new muscle called muscle protein synthesis when you eat a certain amount of protein because whole proteins contain, well, several or three branched chain amino acids. One of them is leucine, and when your body detects that the level of leucine rises in your blood to about three grams, that initiates this cascade of muscle protein synthesis. So if you don't eat three grams, if you don't hit three grams, you're not going to fully initiate muscle protein synthesis. And that's why 30 grams is a recommended minimum at a meal. And if you're going to spread your protein out throughout the day, you just don't want to spread it out in a way that's like, I had 15 for breakfast, and then 25 for lunch, and then like 45 grams at dinner. You're only really triggering muscle protein synthesis with your dinner meal. And I see this all over the place, especially with sort of the older generation, the generation above mine, because people are afraid of eating meat, afraid of cholesterol, afraid of proteins effect on the kidneys, which has all been debunked. And so people tend to minimize their consumption of animal protein, especially. And so a lot of times at their meals, they're getting like 15 grams of protein, 20 grams of protein, if they're lucky, and not getting the full 30 grams. So the 30 grams is really important, whether you have one meal or three or four meals, make sure to get 30 grams minimum, especially, especially the first meal of the day, whenever you're breaking your fast, whether it's in the morning, midday, or at night, that is critically important. And if you have maybe a lunch, say if you have three meals a day, you have a lunch that has a little bit less protein in it, you might be okay because you're still triggered muscle protein synthesis. But then dinner, you really want to bookend it with the 30 grams, but ideally 30 grams minimum at every single meal. When it comes to at least 100 grams a day, that's just because, you know, if you do three meals of 30 grams each time, that's around 90 grams, like give or take up to 100, 100 is a good ballpark for a lot of women to shoot for, especially when they're getting started with eating higher protein. So it's definitely not out of thin air. It has a lot of science behind it. And it is really important for halting muscle protein breakdown, which is that antagonistic process that's happening all the time is our muscle protein breakdown rates are, you know, increasing as we get older and there's things like anabolic resistance that also, you know, start to get worse as we get older. So it's very important to at least get 30 grams of protein at your meal. And then we talked about some ranges on the last episode, but the science out of doctors to Phillips lab and the numbers I always recommend are 1 .2 grams per kilogram of body weight per day. If you're more sedentary, 1 .6 grams per kilogram. If you do some resistance training on your active and then 2 .2 grams or one gram per pound of body weight, if you're an athlete, you're hitting the gym once or twice a day. So that's what you can really take home in terms of what to eat for optimal health when it comes to protein.

Melanie Avalon:
Awesome. Thank you so much. I knew you were going to have the most perfect answer for that. Thank you. I do. I, the protein question is definitely one that like I get where she's coming from with the question because I've, you know, you read all this stuff about like low protein is correlated to longevity and it's just, it's really confusing. At least there's the one thing I think that everybody agrees on with protein is that, that we do need more when we're older. That seems to be agreed upon by both camps.

Vanessa Spina:
Yeah, and I've really changed my thinking recently. We talked about this a little bit, I think last week or the week before, but this whole concept of mTOR, it's really dysregulated mTOR that's bad for us. It's not the mTOR from eating protein or from working out that is bad for us. And so, I'm not really a fan of protein restriction. I think most people really need to lean in more towards the protein and not worry about over consuming it, but be worried about under consuming it, especially after the age of 30, especially after the age of 40.

Melanie Avalon:
I cannot agree more. I think having the mTOR on all the time from eating constantly is a lot different than having an mTOR response from eating a protein meal. It's completely different.

Vanessa Spina:
Yes. For me, it's mTOR all the time activated from too much energy being consumed. That really is what signals growth in the body and not the good growth. You want growth of your muscle cells, you don't want growth of your tissues or your fat cells, right? So I think that's what gets mixed up in some research where they misinterpret mTOR as being bad for us and so therefore we need to restrict protein. I think it's getting the message totally wrong. To me, it's mTOR in the context of excess energy, eating more energy than your body burns off every day, being in a caloric surplus, exactly what you said, eating all the time, not taking breaks. Whereas the mTOR that's being initiated from you building muscle or getting enough protein to initiate muscle protein synthesis, we don't want to avoid that at all. That's what's going to make us strong and lean and fit and able to, you know, be harder.

Melanie Avalon:
to kill. Yeah, it's so different. Similar to like insulin. Like we need insulin as well. It's just having insulin all the time. That's the issue.

Vanessa Spina:
Insulin's gotten such a bad rap and it does so many amazing things for us.

Melanie Avalon:
Yes, it's very, very important, so. Yep, but great question, Jan. Thank you so much. And to all the listeners as well. And if you have your own questions for the show, you can directly email questions at ifpodcast.com, or you can go to ifpodcast.com and you can submit questions there. Today's show notes will be at ifpodcast.com/episode393. Those show notes will have a full transcript as well as links to everything that we talked about. So definitely check that out. And then you can follow us on Instagram. We are @Ifpodcast, I am @MelanieAvalon, and Vanessa is @KetogenicGirl. All righty, I think that's all the things. Anything from you, Vanessa, before we go?

Vanessa Spina:
I had such a blast. I love all the great questions and it was so much fun. I can't wait for the next episode.

Melanie Avalon:
Me too. I had so, so much fun.

Vanessa Spina:
I will talk to you next week.

Melanie Avalon:

Sounds great. Talk to you then. Bye.  Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by Podcast Doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Vanessa: ketogenicgirl.com

Original theme composed by Leland Cox and recomposed by Steve Saunders.

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts - it helps more than you know! 

 

 

Oct 20

Episode 392: Protein Needs, Coffee, Ice Cream, Spermidine, Longevity Supplements, Rapamycin, Telomeres, The Uncanny Valley, And More!

Intermittent Fasting

Welcome to Episode 392 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Vanessa Spina, author of Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

SEED: This episode of The Intermittent Fasting Podcast is brought to you in part by Seed. Seed's DS-01 Daily Synbiotic is a 2-in-1 prebiotic and probiotic formulated to support gut health, skin health, and overall well-being. With clinically and scientifically studied strains, Seed's Daily Synbiotic promotes digestive health, boosts immune function, and enhances your body's nutrient absorption. Start your journey to a healthier you with Seed's innovative and effective synbiotic formula. Go to seed.com/ifpodcast and use code 25IFPODCAST to get 25% off your first month of DS-01®!

LMNT: For fasting or low-carb diets electrolytes are key for relieving hunger, cramps, headaches, tiredness, and dizziness. With no sugar, artificial ingredients, coloring, and only 2 grams of carbs per packet, try LMNT for complete and total hydration. Be sure to try the new LMNT Sparkling — a bold, 16-ounce can of sparkling electrolyte water. Go to drinklmnt.com/ifpodcast to get a free sample pack with any purchase!

To submit your own questions, email questions@ifpodcast.com, or submit your questions here!! 

SHOW NOTES

SEED: Go to seed.com/ifpodcast and use code 25IFPODCAST to get 25% off your first month of DS-01®!

LMNT: Go to drinklmnt.com/ifpodcast to get a free sample pack with any purchase! Learn all about electrolytes in Episode 237 - our interview with Robb Rolf!

Spermidine is essential for fasting-mediated autophagy and longevity

Episode 379: Special Guest: Chris Rhodes (Mimio), Fasting Mimetics, Anti-Inflammatory, Autophagy, Fasting Metabolites, OAE, PEA, Spermidine, Nicotinamide, And More!

Go to mimiohealth.com and use the code IFPODCAST to save 20% off your first order!

Ion Layer: Get $100 off with the code melanieavalon at melanieavalon.com/ionlayer.

Get 10% off with code MELANIEAVALON at melanieavalon.com/truage!

Get 20% off with code MELANIEAVALON at melanieavalon.com/agerate!

Go to insidetracker.com/melanie and use the coupon code melanie30 for 30% off all tests sitewide!

Listener Q&A: Nicole - I am having a hard time getting two protein rich meals in before bed at 10.

Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.

TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.) 

Melanie Avalon:
Welcome to Episode 392 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of "What, When, Wine" and creator of the supplement line AvalonX. And I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of "Keto Essentials" and creator of the Tone Breath Ketone Analyzer and Tone Lux Red Light Therapy Panels. For more on us, check out ifpodcast.com, melanieavalon.com, and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Melanie Avalon:
Hi, everybody, and welcome. This is episode 392 of the Intermittent Fasting Podcast. I'm Melanie Avalon, and I'm here with Vanessa Spina. Hi, everyone. How are you today, Vanessa?

Vanessa Spina:
I'm doing great. I have my chocolate protein ice cream here because this is usually when I have my chocolate ice cream, my protein ice cream after dinner and we're recording afternoon time and I was like, I didn't have my ice cream while we were recording today. And I just discovered I've started making different flavors of it. So I made a strawberry one, Luca and I usually share the ice cream together. I made a strawberry one just putting fresh frozen strawberries in it the other day. And then I just put cocoa in it and it made it chocolate flavor. Yeah, that's what that's what I'm having right now. I go down the road.

Melanie Avalon:
rabbit hole, looking at all the different ice creams that people make. I went on a rabbit hole the other night trying to see if you could make ice cream from just fruit, like without adding anything. Like a sorbet? Yeah, basically, because I'm already eating pounds of fruit. I was like, maybe I could get one of those machines and make this into like a cool sorbet thing.

Vanessa Spina:
If you had like the Ninja creamy, which I'm using, if you just blended that up, like I do that for Luca sometimes. I just do fresh fruit, like a banana, a mango, some blueberries, raspberry, strawberries kind of thing. And I'll do, I'll just put almond milk in it and sweet. Actually for him, I usually do regular whole milk. I just blend that up and then you freeze it and it turns solid. And then you just run it on the light ice cream setting the same as with the protein ice cream. And I actually put some protein powder in there sometimes for him too, but he loves it. It, what's amazing about it is that like my protein ice cream I'm having right now is just two scoops of protein powder and unsweetened almond milk. That's the only thing in it. And that, when I do it that way, it's vanilla ice cream, but it's the texture that makes it so creamy and ice cream like. So actually if you want, I can try doing that exact combo and let you know if it turns out like ice cream in the creamy.

Melanie Avalon:
just fruit. I basically want to do just blueberries with nothing else.

Vanessa Spina:
Yeah, I usually make my shake with strawberries, raspberries, and blueberries, so I could try it like that. Yeah, Luca and I would probably love it. So I'll let you know if it turns out like an ice cream like texture, it might need some protein powder in there too, which you could use toned protein for, which is what we put in ours. But it just, I think the protein powder makes it a little bit more the texture of ice cream, maybe because of the milk, like the fact that it's derived from milk or something. But I'll try it and I'll let you know.

Melanie Avalon:
please do. I was looking at it and I was like, hmm, this is going to take a lot of time. So, because I would have to, it looks like I needed to blend the blueberries and then freeze them for a long time and then run them through the machine. I was like, that's a lot of extra effort.

Vanessa Spina:
But I am intrigued. I've been doing it all week because our in-laws are visiting us, so I'm also making them ice cream. So when I make them ice cream, I use cream and egg yolks and honey and vanilla, all the regular stuff for ice cream. So I'm blending it first and then I have to wait until the air bubbles go down a bit and then I put it into the container and then I freeze it. So yeah, it's a couple of steps, but I'd say it's definitely worth it.

Melanie Avalon:
I've said this before, but I'm really shocked that there's not yet a machine that does this instantly. I'm really, really shocked by that. That there's not a machine where you can just put in your, and it makes ice cream. Like, what year is this? I just feel like that would be, like, you know? I know. Like, the machines at Dairy Queen and McDonald's, do they pre-freeze stuff or do they just put in the liquid and it comes out ice cream?

Vanessa Spina:
I don't know. I've been thinking lately that because I make iced coffees for Pete a lot that the best iced coffee would be if you made it and then froze it and then you blended it with something like a creamy because when you add ice to drinks, it just dilutes the flavor. If you just made like pure coffee, like he has a mocha, so it's like chocolate almond milk with espresso. If I just froze that and then made it, I want to try it. Actually, it'll probably just taste like ice cream.

Melanie Avalon:
Like a coffee ice cream. Speaking of coffee, this is a super teaser, probably won't happen for a long time. And, but, and I'm thinking of making a coffee line. Ooh. But that's, it's a ways off. We're at the like very baby stages of exploration, but I have an idea that I'm really excited about. So listeners get excited because I think I've, I'm really excited is the point about a unique aspect of coffee I would like to focus on. Love it. Also, we had some technical difficulties getting this episode going, and I realized it was my headphones. I was the problem. It was like definition, like I am the problem. But the reason was I can't believe, okay, Vanessa, when you record, do you plug your headphones into the mic or into the computer? I don't use headphones. Right.

Vanessa Spina:
Okay, ever, which is like, I don't know podcast blasphemy or something like everyone, every single person who podcasts, wears earphones and I don't I don't like it. I feel like I can't hear properly or like, I don't know. I just I've never liked it. So I've never used them. I don't know actually why people use them.

Melanie Avalon:
this might, I think they use it for, this is the point of the story actually. So I had been for seven years or seven and a half years of podcasting, plugging my headphones into the monitor, like the computer itself, which all that does is lets you it lets you hear the other person. It doesn't do anything beyond that. Besides, I'm assuming it probably helps with like feedback and things like that. I just realized because I was recording with Scott for our Mindblown podcast, which teaser everybody check out. We talked about so many fun topics there. We were recording our episode on magic secrets in the Disney parks, like how they actually make everything so magical. But it was a really fun episode. Regardless, he convinced me to plug my microphone, sorry, my headphones into the microphone. Do you know what that does? It's like a monitor. Now I understand what you were just saying. Now I understand why people wear headphones. You hear yourself in your head.

Vanessa Spina:
Yeah, that's what I tried the first time and I didn't like it.

Melanie Avalon:
I didn't either.

Vanessa Spina:
You should try again.

Melanie Avalon:
Yeah, this is like a game changer. I feel like I'm going to upgrade my podcasting skills, because you can actually hear yourself. So I'm like, Oh, I need to enunciate better. I need to, whoo. It's like, it's like makes you it's really weird because you hear yourself in your head, but you hear what you're saying. So I feel like it's gonna make me a better human being, honestly.

Vanessa Spina:
That's a good idea. I should try it. I want it into your mic. I like looking.

Melanie Avalon:
Does your mic have a headphone? There's a... Yeah.

Vanessa Spina:
There's a headphone jack, but I don't know what I would need so I'm moving the mic around

Melanie Avalon:
Yes. So it's just funny. It's really interesting just as a life experience to be doing something for so long and then have this epiphany moment. So I feel like I'm a brand new podcaster right now.

Vanessa Spina:
That's awesome. That's really exciting. I'll have to try it.

Melanie Avalon:
Yeah let me know. Will anything else new or shall we jump into everything for today?

Vanessa Spina:
Yeah, excited to talk about these questions today.

Melanie Avalon:
Awesome. Well, to start things off, I found a study I really wanted to talk about. It's called Spermidine is essential for fasting mediated autophagy and longevity. It's August 2024. So it's, whoa, actually, it's five days old as of this recording. And it is super technical. So I'm not going to go into the details of it. But the reason I was really fascinated by it and drawn to it is a few reasons. I've been intrigued by Spermidine for a while for two primary reasons. One, when I interviewed Dr. Michael Greger for his book, How Not to Age, he had a big chapter or section on Spermidine, which is a, well, it's a compound that our bodies create and also it's really high in food. And like he talked about this one study where they looked at all these different foods and tried to find the main or the one compound that was most linked to longevity and it was the Spermidine content, which is very interesting. And then on top of that, we've talked about a supplement on the show called Mimeo, which is a fasting mimicking supplement. Basically, you take it and it creates the metabolites, which are also created by the fasted state. We can put a link in the show notes to the interview we did with the founder. And if listeners are interested in that, they can also get 20% off with the code IFPodcast at MimeoHealth.com. That's M-I-M-I-O-H-E-A-L-T-H.com. But in any case, back to this study and Spermidine, oh, and the reason I bring that up is that supplement contains Spermidine as one of its four ingredients. But this study, I started reading it because I was really curious what they were going to say about Spermidine and fasting and autophagy. What I loved about it is in the beginning, they literally said what we've recently been talking about a lot in this show, which they start off by saying to date, it remains uncertain whether IF offers health benefits due to the temporary cessation of calorie intake without CR or due to a net reduction of total calorie stefacto resulting in CR. So basically, they acknowledge this ongoing debate we have about are the benefits of fasting just due to calorie restriction. And then they go in and talk about all of the health benefits of autophagy and how it's linked to longevity. And then they talk about the role they've seen in autophagy's connection to Spermidine in particular. And their research was looking at how dependent on Spermidine is autophagy and fasting. And they actually concluded that at least partly Spermidine is essentially required for the autophagy benefits from fasting, which I found really, really interesting. So their actual conclusion was our study reveals that fasting induced longevity and improved health span partially rely on Spermidine dependent, and then it's a little technical E1F5A, hypo-insuasion, and ensuing autophagy induction in multiple species. So basically, long story short, at least part of the longevity benefits from fasting are likely from the autophagy that is coming from a process that is dependent on Spermidine in multiple species. So I thought that was really, really interesting. What are your thoughts, Vanessa?

Vanessa Spina:
Yeah, it's so interesting. I love that you interviewed Chris at Mimeo. I also love that company. And it was so interesting talking to him about how they went through so many studies on fasting and found these three metabolites were always present when people were doing the extended fasting. And spermidine, I hadn't really heard of until Chris and Mimeo, but then I actually, once I started researching spermidine, I saw that it was actually already kind of in a step starting to be established. I think you, you were maybe telling me that there was a couple of companies at the biohacking conference that were doing like a spermidine. Was it you that was telling me that?

Melanie Avalon:
Yeah, I actually, oh, I forgot about that. So not this most recent biohacking conference, but the one prior, so the first one I went to, I ended up hanging out with one of the guys from Spermidine Life, I think is the brand. And prior to that, I've been hearing about Spermidine, like, you know, casually, like, I feel like people were talking about it. But then when I like hung out with him for so long, I was like, oh, this is, he was really convincing. But then it wasn't until I really dived into it a little bit more, like with Michael Greger's book, and then talking with Mimeo, that I was even more intrigued. And then reading this study, I just found it so interesting.

Vanessa Spina:
you think of it? Do you think that people should take it as a supplement?

Melanie Avalon:
I don't know. So some of the things they did in this study was they would basically look at organisms that couldn't create spermidine for whatever reason, and then if that happened, they wouldn't get the benefits, the autophagy-related benefits, and or they would restore impaired autophagy by supplementing spermidine. I think I need to know more. I'm very intrigued. I want to research more. I guess I would be curious about the levels in people's diets anyways. I would like to go look at that chart in that study that Dr. Greger references where they look at the spermidine content and all these different foods. It does make sense that in a way it could be sort of like a safeguard to assure that you're getting the proper levels of autophagy from your fasting. I don't see how it can hurt for sure. And after interviewing Chris at Mimeo, it just made even more sense about why that one ingredient in particular would be in their supplement. And what I like about it, maybe this is what really resonated with me, and we talked about this with Chris, but he was talking about how these are the metabolites that are created from fasting. So one of my big questions was, well, are we just creating the metabolites like a picture that looks like fasting without actually fasting? So are you getting the benefits? And he addressed that in the episode. But on top of that, this study makes it clear that this is an example where no, that actual ingredient, that actual compound is required for the fasting benefits. So yeah, it's definitely made me even more intrigued in spermidine. And I want to look into it more. And I kind of want to make my own spermidine the more I think about it. Yeah, you definitely should. I really might. Like, I really am thinking about it. I should look into it some more.

Vanessa Spina:
It also makes me think of Timeline, that other company I was telling you about. What did they do, again? With the Mytopyr, they created this, they discovered urolithin A. Oh, right, right, yeah. And it's, they're very similar, Mimeo and Timeline, in terms of how the process that they went through of doing, looking at the processes and things that happened during autophagy, and then what is happening in the body with autophagy, and then how can we sort of replicate that. It's very similar to the process that Mimeo went through, where they went through all these studies and then started finding these commonalities. I think it's interesting, too, to supplement. It's so hard to, it's like the biggest pain point with the longevity industry in supplement. It's so hard to actually know if anything that you take increases your longevity because you won't know until, you know, until the end of your life, and you'll never actually

Melanie Avalon:
There's no control. There's literally.

Vanessa Spina:
no control. What I found really interesting, this is one of the things I was really challenging their CMO. I interviewed their chief medical officer who's done most of their research. This was just last week on Thursday. I was like, how can people tell that what you are creating with this supplement does anything for anyone if we can't actually tell? It's like, I've got all this NAD, all this different NMN, all these things in my fridge. I'm like, I don't take a lot of them because I just don't know. I don't know if any of them are worth taking and then you have to take something for the rest of your life and you'll never know. I was really challenging him on that. He said that they are actually creating a test where people are going to be able to check their mitochondria and check the health and function of their mitochondria. They will actually be able to take, for example, with Mitopur, the year less than eight works on the mitochondria and activates mitophagy, the autophagy of mitochondria. You can actually take it and see. They're working with this new company called MiScreen. They were at the conference, actually. Yeah, so MiScreen. They're doing a version of biological age, but based on your mitochondria. There's another company as well that he mentioned to me that is working on something that people will be able to test just at home and be able to get some feedback and markers. I think it's really going to change the supplement industry when it comes to longevity because people will be able to take things, say, for three months, four months, and then test and see if it's actually doing anything for you because you can do lots of RCTs and everything. And that helps show results. There is so much psychological effect to taking these supplements. What do you think of longevity supplements?

Melanie Avalon:
I, it's really interesting because it's basically a lot of what I do is, you know, the longevity sphere. I get really intrigued when there is a lot of research that makes sense surrounding mechanisms. I'm just going, okay, so not to go on like a complete tangent, but so like let's look at the different longevity related supplements. So the OG is probably rapamycin. I think that one does seem to be probably the most likely or vetted longevity supplement. I, I'm sad that it is behind so many barriers. I understand why because it's a drug and it's mostly, you know, created for immune type conditions. Does it relate to cancer? But basically though, and the reason I find it really likely for longevity is I think it's the only compound I think that has been shown in every single species that it's been tested to extend lifespan. You were talking about how, you know, with, with a human, you can't know if you would have lived any longer or shorter. So there's no control, you know, but when we do animal studies, that's when they can control for that a little bit because they can basically make, you know, identical, you know, yeast strains or rats and put them in completely identical situations and really control it and see what the difference is. So rapamycin seems to be the one that consistently extends lifespan in all species. Kind of like when it comes to dietary interventions, calorie restriction is the one thing that seems to always extend lifespan. But then you move on to things like resveratrol and it was really seen as this great longevity supplement. And then there was a lot of scrutiny around how the studies were conducted and they say that, you know, the majority of the findings were based on this one faulty study. You know, moving beyond that, we have now the world of like NMN and NAD. There's a lot of debate around NMN, NR, NAD levels. And we know just how important NAD is and metabolic health and functioning and everything. And we know that it's depleted by things like aging and stress and sickness. Like we see that. So to me, it just makes sense that boosting NAD levels would have this effect. And I know people agree and disagree with that. I know for me personally, like I use historically, I was using NAD injections. I wasn't, I was not liking how they felt. They did not feel good to me. Just like in the moment, they made me feel quite not well. And I was like, I don't know if I want to keep, because it was really expensive too. And I was like, I don't know if I want to keep spending all this money for, to not feel well and just to, you know, think that I'm doing something good. But then I found, or actually they reached out to me, but I found any NAD patches by a company called Ion Layer and I am obsessed and I feel a difference. So I use one, I use one after, because I typically go out once a week socially and I try to really control my wine choices and things like that. Sometimes it's, sometimes I drink, you know, drinks. I are not dry from wines and, you know, more than I probably should. If I wear a patch the next day, that night and or the next day, major game difference just in how I feel. And so that to me feels like it's really doing something. And this is the Ion Layer NAD patch. And so I can really see how it just makes sense to me that supporting NAD levels long-term would really be supporting longevity. And if listeners are interested in those patches, again, I am obsessed. You can go to melanieavalon.com/ionlayer, I O N L A Y E R and use the coupon code MelanieAvalon for $100 off. But beyond that, so all of these new supplements, so Spermini, for example, like I see there's so many good studies on it and longevity and, you know, like this one that we just looked at is so fascinating. The takeaway is for humans, you are never going to know how long you would have lived with different dietary supplemental interventions. You just won't know. I mean, unless. trying to think of how you would know. I know now we have like virtual twin studies type things where you know they basically make a computer model virtual twin version of yourself and see what would happen. So technology and AI and stuff are advancing towards that but in the end you're really not going to know. So how can you know that what you're doing is actually benefiting you? And I do like all of these different biological age tests. I think they are good markers of how things are affecting you. The issue is they're all so different and they're all looking at different markers. And like for example I recently just tried two completely different companies for biological age tests. Like one was looking at DNA methylation. I think they were both looking at DNA methylation which I was excited about. What was interesting was they both provided panels of biological age and all that and I got different scores and different aging and I took them both around the same time on similar markers with the exception of I thought this was exciting. They both measured my telomeres and that was what I did the best in on both of them. So that was exciting because people often say that telomeres are one of the primary indicators of longevity status even though they do change very quickly. But basically they're kind of like the shoe caps on the end of if you think of like you're tying your shoes like the little caps at the end and they get shorter as you age. And so the length of your telomeres has been linked to longevity. So like for example on those tests I did I got really good scores on that. So and then you were mentioning Vanessa with the mitopure how they are testing looking at the actual mitochondrial function. And so and then on top of that I'm just all the issues. On top of that there's the issue of say you start taking a supplement. It's really hard to just change one thing in your life consistently. Things are changing all the time. So controlling for that is another another aspect. I think all you can do is like there's a lot of data out there. I will find and put in the show notes links for the different biological tests that I aged tests I did recently. All of that said I think what people can do is you know try if they're interested try the things that have the most data behind them and monitor your markers. And I use inside tracker ongoing. They have a biological age test but it is it's all like blood panel type stuff. But you can get I really think you can get a good consistent look at your metabolic health if you're regularly testing. I don't I mean knock on wood. I'm really hesitant to say this because I could always be wrong but I don't think it would hurt to to try these different compounds especially because they have to go through so much you know bedding and and things like that and you know safety studies. It might hurt your wallet and not be doing anything. I don't know. I'm really I'm really excited by it and passionate about it and I do agree that there's a lot of nebulousness. So that was long. Do you have thoughts?

Vanessa Spina:
No, I love everything that you shared, you know, and I think for me, the bottom line when it comes to all the research that you mentioned is, you know, you, a lot of these things we see extends lifespan by, you know, multiple factors when it comes to like yeast, these small, what are they called that Mimiya was using, was testing on. They're not used? Timeline was also testing, they're called, it's like these small. It's not small.

Melanie Avalon:
The elegance, is it?

Vanessa Spina:
C. elegans. Yeah, great. Thank you. Yeah, both Mimeo and Timeline were testing on C. elegans, which apparently make really good test subjects for longevity and lifespan testing. And then when they move on to, you know, you might see lifespan quadruple in those smaller species, and then you move on to more complex species like monkeys, and you see it helps them to extend lifespan maybe a little bit. But then I think in humans, what it really does for us, it definitely can't reverse age, like it's not possible to reverse age unless someone is using like a time machine or something, because you basically can't go back in time, like you can just stop, you can slow the aging process. And I think for humans, the best we can hope for and expect for is that we would live longer by avoiding a lot of the chronic non-infectious disease that people die from these days. So I think all these supplements can help with that. I think a lot of like basic fundamental things too, like exercise and, you know, really nutrient dense, proper diet, like those kinds of things can really help. And then there's all those other layers that you can add on. And then if you're interested in these kinds of supplements, I think that these tests are coming soon. I think they're on the horizon where if you're someone like me and you don't want to just take something and spend money on it for the rest of your life, hoping that it'll do something, you can actually test it. And that's when I think I'll become a lot more interested in all of this stuff. And there are some tests already for biological age, but I think for mitochondrial health, that will be really exciting. And then there's so much you can do for mitochondrial health already with exercise, but to see if there's something that can level you up even more to actually be able to test for it. I think that's going to be just a game changer.

Melanie Avalon:
Yeah, just one comment on that about reversing aging. I know we can't right now. I am really excited or intrigued about that potential. Like I wonder if that is the future. And I know that's what David Sinclair talks about a lot in his book Lifespan. Dr. Walter Longo will talk about it. Basically, it's the idea that we know, like in theory, we should be able to because in theory, we know we can have cells that are reset to the ultimate state of youth because we have embryos. So we can have inside of us a cell that is completely young. So in theory, the cells should be able to somehow revert back to that state. I feel like that's like the ultimate future of longevity. I'm really intrigued by it. I don't know if it'll ever happen and or if it'll happen. I don't know. We'll see. But basically, one of the big questions out there, like will we reach escape velocity or like how long will you need to live to reach the state where the anti-aging technology will advance so fast or exponentially or to the point where it'll always stay above where the aging cap is now, if that makes sense. I'm super curious about it, which Vanessa, have we talked about this? This is the question I ask a lot of my guests when they come on. Have I asked you this? Would you want

Vanessa Spina:
to live forever. I'm trying to think if you asked me that when I came on your podcast.

Melanie Avalon:
I don't know. Yeah. I don't know. I don't think I, I don't think I did. I typically ask it to the, like, like the longos and the Sinclair's and all of them.

Vanessa Spina:
make sense. That's their specialty. And a lot of them have probably considered it, whether or not they would. I think about it a lot. Part of me wouldn't, and part of me would. It depends what I think about. There's a piece that I get from knowing that at some point, I won't exist anymore. But there's also the thought of Luca and Damien and Pete and my family and friends and how much I love them. And the thought of maybe being able to... Something that might happen in our timeline is being able to be uploaded to some kind of technology or singularity merging with technology in some way where you mentally would be living forever, existing forever. Forever seems like a long time, but maybe just extending lifespan as much as possible. What about you?

Melanie Avalon:
It's so funny because I literally, I always thought everybody wanted to live forever. It's not even a question to me. The longevity people that I ask, like I said, the David Sinclair type people and like Saria Young and Walter Longo, they all want to live forever. But I feel like everybody else doesn't really. Most people seem to not want to. I do. Yeah. I just want to, yeah, there's so much I want to do and keep doing. And this is all assuming that health span would be equivalent to lifespan. So I think a lot of people think living forever, they think, oh, well, I'll be living old and decrepit and can't move. I would not want that. So this would be assuming that I'm living forever in a state of vitality that I would want for sure. I know what you mean, though, about something a little bit comforting, about the idea of not non-existing, at least for me.

Vanessa Spina:
forever eternity is long so yeah at some point having an end I don't know it's like is there in either or or can it be like eternity but I can go when I want to kind of thing

Melanie Avalon:
Maybe. I mean, the way I would combat the attorney being a long time is... I mean, the nice thing about there being an end is it adds a sense of urgency to doing what you want to do because time is short. If it was longer, I'd be like, oh, I have more time to do everything I want to do. And then maybe I could take like some breaks. Yeah. Deep esoteric thoughts. But I definitely, I definitely did. Like that was a moment for me because I literally thought everybody wanted to live forever. And I really, I've quickly realized that most people do not want to.

Vanessa Spina:
Ask me on a different day, you know, like a day that you're having a super blissful existence. You might be like, yeah, I want this forever. And like a bad day, you're like, yeah, I think I'm good. But I think it's hard for us to accept death like within our lifespan. It sometimes seems too short to me, especially the older I get. I'm like, man, it seems short, but it's just having such a wonderful time in life. And it also depends how you're feeling. And I think there's something I've always thought there's something about aging, especially towards the end, where it's almost like a way to make it easier to leave, you know, because if we stayed in like our prime, our whole lives up until the day we died, it would be pretty sad to suddenly just no longer exist. But when your body starts to get a bit worn out and frail, and you're not able to do all the fun things anymore, it's like, okay, maybe we had a good run.

Melanie Avalon:
You know, that, that is true. And like, like I said, it goes back to the, I think when people cure that question, they think it, they think of it in the context of our current state of aging, which obviously makes sense because that would be the practical interpretation of it. Yeah. I'm really curious to see the future of all of this. I don't think the answer is going to, I don't know. I don't think the answer is going to be in any of these compounds. Like I think these compounds just promote longevity. But if we were to actually reverse or stop aging, I don't know what that would, you know, entail, but I guess we'll see. What I don't like, what creeps me out, because you're talking about uploading your consciousness to some other, you know, thing that, that, that I'm okay with. Well, the thing I don't like is something that I think practically actually is happening right now. And it's, it's like this idea of uploading, basically creating, they're, they're doing this thing where they want to like create simulated versions of people. So basically you upload like the entire data of a person to this avatar. So then like, oh, little kids can talk to their grandfather. That's no longer with them. Like that just seems weird to me. Because it's like, I don't know that that's weird to me. It's like an AI avatar type thing.

Vanessa Spina:
I saw something like that. I opened Instagram and it was like this mother, they created this virtual version of her son who had died. It upset me so much that I was like, I had to just turn off my phone and go to bed. I was just like, okay, that was enough on the internet today for the day. Some things are just a little too unnatural. Things we probably shouldn't be messing with.

Melanie Avalon:
Yeah, it's like the you know, the phrase uncanny valley. It's the idea that when something is really, really close to I don't know if it just applies to humans, I think it's okay. So it's basically it's a hypothesized psychological and aesthetic relation between an object's degree of resemblance to a human being and the emotional response to the object. That's why I hate wax figures. Yeah, it has to do with basically like how similar something like a wax figure or a robot is to real life. But if it's like slightly off and you have this like eerie unsettling feeling, that's uncanny valley. There's literally a word. There's actually like a word for it.

Vanessa Spina:
Yeah, I've never understood why I hate wax museums and wax figures so much. That just explained it for me, so thank you. Yeah.

Melanie Avalon:
uncanny valley. So it'll be curious, it'll be interesting to see if we, you know, get past that. Like if the technology will actually, I don't know, crawl out of the valley, like actually be a perfect replica. Because if it's not, then it's a problem. But yeah, I would not want a virtual, kind of similar to the people who get like the clones of their pets. That would be weird for me too. Have you seen that before?

Vanessa Spina:
Yeah, that's I had I had not seen it, but that sounds horrible.

Melanie Avalon:
Yeah, I know that's been done like people have had a pet and then they it dies and they clone it So then they have the pet again

Vanessa Spina:
It's not a weird concept. Yeah, I mean, I can understand. It's hard, you know, to let go of things. And that's why I got so upset by that video of, you know, the mom with the kid that was recreated virtually. Because I was like, that's something I would probably do if I lost a kid. So like, that's so horrible. But anyway, yeah.

Melanie Avalon:
Yeah, yeah. Okay, should we answer one more question? Yes. All right, so we have a question from Nicole and this was on Facebook and she says, I work from 7 .45 a .m. until 2 .30. No break and I'm constantly moving. I enjoy fasting during that time, but I'm having a hard time getting two protein-rich meals in before bed at 10. I absolutely would hate to eat before work as I feel like I'll be starving before the end of work. What is the best thing to do with this work schedule? It's a Monday through Friday schedule. Okay, do you have thoughts, Vanessa?

Vanessa Spina:
Yeah, so I love the fasting from 7 45 to 2 30 because when I'm working, I also love fasting, especially when I'm moving around a lot, getting a lot done. So I love that you're enjoying fasting during that time. So I think from two 30 to 10, you have a lot of time to get two protein rich meals in if you're finding it hard in terms of maybe the size, just focus on getting 30 grams of protein at two meals. That's all you really need. If you're trying to get into meals, 30 grams, you can do in one protein shake. So just one scoop of whey protein isolate with some almond milk, ice, you know, whatever else you want to throw in there, you're going to get 30 grams of protein. And that's the minimum you need, you know, to hit that leucine threshold to initiate muscle protein synthesis. So if you, if a protein shake helps you, it takes out at least one of those meals. And then you can focus on, you know, with the other meal, you know, just eating. I'm not sure if you like to eat just animal based proteins or, you know, dairy or whatever it is, like a mixed meal with chicken breast and yogurt or cheese or whatever it is, you, however it is that you like to get your protein in, if you're having steak and then maybe some dessert that has some protein in, you should be able to hit 30 grams again with that other meal pretty easily. So I think two 30 to 10 is like a great amount of time for two meals. Like that sounds very similar to the way that I eat a lot of days getting, you know, two meals in, in my fasting, in my eating window, three meals is a lot, unless I'm doing a much longer eating window. But for an eating window of about seven and a half hours or 10 hours there, I mean, eight hours there, uh, you should, shouldn't be too hard if you just focus on, like I said, 30 grams of protein. You don't have to eat 50 grams of protein or a hundred grams of protein at each of your meals, you just want to hit at least 30 grams and do that twice. So hopefully that, that should help. And 30 grams, you can easily achieve with meals that I mentioned there, just having you know, one or two protein sources in your meal or, you know, adding in a protein shake, or I like to do my first meal of the day is usually high protein, low fat, plain yogurt with some protein powder in it and some freeze dried strawberries. I don't know why the texture combination just tastes so good. And it's a huge amount of protein. I think I get 60 or 70 grams of protein from that meal. And it still feels light enough that I can work out after that and not feel like I've had a massive meal. So lots of different options, I think. And don't worry about having to eat so much protein. I think you can probably hit it with less than what you're maybe imagining. That's my take on it. What do you think, Mani? So that's.

Melanie Avalon:
That's really interesting. So you think that's enough protein if they just had 60 grams in a day?

Vanessa Spina:
Well, if you initiate muscle protein synthesis twice, you're probably doing fine. If you're sticking to two meals a day, I would just hit at least 30 grams. You can definitely eat more than that. I'm not saying just have 60 grams for the day. I'm saying just make sure you hit a 30 gram minimum. If that's all you can have, you'll probably be fine in terms of your muscle mass, but eating more of that will definitely help if your goals are to put on more lean mass. But the minimum would be 30 grams at each of those meals. So you could do that, like I was saying, with a protein shake. But depending what your goals are, it sounds like you want to stick to two meals. I wouldn't worry about having to eat tons and tons and tons of protein beyond that because 30 grams does give you about three grams of leucine. So you're triggering muscle protein synthesis twice. I mean, you could add in a third meal of another, like if you have two regular meals in a protein shake, you could add that in. But I guess you don't, you kind of have to go by your hunger to and like what feels good to you. Okay. Yeah.

Melanie Avalon:
interesting. I would suggest getting a little bit more, if you're just having two meals, I would be a little nervous with just 60 grams of protein a day. So I would probably, and for some people, I mean, I know it works for some people. I think Dr. Gabrielle Lyon recommends like 1 .2 to 1 .5 grams of protein daily per kilogram, which I'd have to do some conversions, but I think that comes up comes out to a little bit more. So I guess the way I guess what's interesting is I see I see it as two, two equations that need to be fulfilled. One would be the 30 grams at one time, and then one would be the total amount for the whole day. For me, I like a little bit more than that. But the nice thing is because I think people feel like it's a really, you know, it can be overwhelming to get enough protein. But if you think about it, if you have just a chicken breast, I think what I think a lot of the issues is pairing what you're pairing the protein with and just making the meal to say shading so it's, you know, too much to eat seemingly. But if you strip it down to the basics, like a chicken breast by itself, just, you know, like a decent sized chicken breast, you know, you're probably going to get over, you know, over 50 grams of protein in that probably in that chicken breast, right? Let me let me check.

Vanessa Spina:
So 1 .2 grams per kilo is a great place for sedentary individuals and that's the range that I also recommend based on the work of Dr. Stu Phillips at McMaster. So 1 .2 grams per kg for sedentary, 1 .6 grams per kg for more active individuals up to 2 .2 grams per kg for athletes. And 1 .2, if someone's at like 60 kilograms, that's like 72 grams of protein for the day. So if you do two meals where you're getting at least 30 grams of protein, you're pretty close to that. Like that's 60 grams. You're like eat five more grams of protein at each meal, like 35 grams around that. Like I was just saying 30 as a floor.

Melanie Avalon:
Okay. So because if a person's like, I hate all the conversions. So if a person's like 120 pounds, that's 54 kilograms. So that would be like, okay, 64. Okay. Yeah. So 64 grams. Yeah. And then if, so if you're, if you're going a little bit higher, like 1 .5 would be 81.

Vanessa Spina:
Yeah, I like 1 .6. Some people say 1 .5. If someone is doing resistance training, if they're more sedentary and not doing resistance training, then 1 .2 for more sedentary adults is a recommendation from the top experts on protein. So Dr. Gabrielle Lionstein is really 30 grams of protein per meal. If you're having three or four meals in a day, don't do like 20 grams, 20 grams, 40 grams, because then you're not going to initiate muscle protein synthesis at those first two meals, and then you will at the last one. It's like do 30, 30, 30. If you're not having 30, you want to get 30 and then 30, and then add whatever else you want on top of that, but just make sure to get at least 30. That's the floor. Most people who are not lifting weights will be fine at 1 .2, which is somewhere between 60 to 70 grams for a lot of people. That's actually also the number on keto diets to help people get into fat burning. But if you are someone whose goal is to build muscle, you probably need closer to 1 .6 to 2 .2 grams per kg, and that's 2 .2 grams per kg is equivalent to 1 gram of protein per pound of body weight.

Melanie Avalon:
Awesome. Okay. And the nice thing is, so say you focus on the 30 grams from like the source material of the protein, if you're filling out that meal with other things, then you are, you know, adding a little bit of protein as well. But I think one of the good things that people can realize or think about is, so if you just had two, you know, decent sized chicken breasts in a day, that's, you know, pretty much fulfilling that protein need. And that's, that's not hard, like that's two, that's two chicken breasts at two different meals spread apart. I think the problem is people see it in the context of, you know, all of this other food you're eating with it. But if you, if you just start with the basics, like start, start with the protein. So this is the chicken breast and then fill out, you know, beyond that. And I'm just using chicken breasts as, you know, as an example here. But I think if you just focus on that as like the foundation and then fill out beyond that, rather than approaching it as like, what is the overall big meal? It's kind of like just a mindset perspective approach. I think people can realize it's not, it's not that unapproachable, especially in we're saying she's, she's got a pretty decent, you know, almost eight hours to get that in. And again, I know I'm, I know I'm coming from my perspective where I literally pounds and pounds and pounds of protein. So I'm like, Oh, it's easy. And I understand people come from different perspectives and it can seem more intimidating to

Vanessa Spina:
Definitely. I think that is the question I get the most when people are starting with a higher protein diet is how do I eat all the protein? Like how? So for me, things like protein shakes are a game changer because you just get a whole meal in. You get one of those. And then for people who are doing plant-based diets, who are not eating animal protein, the floor is 35 grams. So you want to shoot for 35 grams at each of your meals as the minimum. You can eat up to 100 grams of protein at your meals and you're not going to waste that protein. Your body's going to actually use it, which we now know according to my favorite study that came out in the past 12 months. So you can eat as much as you want in terms of protein. There's also a lot of research showing that the more protein you eat, the more fat burning you actually get in a lot of cases, the more lean body mass you get. So you can't really go wrong with overshooting the protein, but as long as you get a minimum of 30 grams, if you're eating animal-based proteins and 35, if you're eating plant-based proteins, then you should be totally fine in terms of preserving your lean body mass. But then again, if you want to grow it, 1 .6 is a better target and 2 .2 if you're in the gym twice a day, at least.

Melanie Avalon:
I love it. I love it. A good example just really quick, you know, they'll often have at those restaurants like, eat the pounder and pounder burger and win a shirt or eat this meal and win a shirt. It's like the difference between if you have the burger with the bun, which is like not that much more calories versus just the burger, you'll get so much more full eating the burger with the bun and it might even be like difficult compared to just the burger. Like, so that's what I mean by just like starting with the protein as the foundation and then intelligently filling out beyond that. It's doable. I promise it's doable. Awesome. All right. Any other questions or things before we go?

Vanessa Spina:
Thank you for that excellent question. I really enjoyed all the conversation today. Me?

Melanie Avalon:
me too, deep esoteric things about life. Well, this has been absolutely wonderful. A few things for listeners before we go. If you would like to submit your own questions for the show, you can directly email questions at ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. You can follow us on Instagram. We are ifpodcast. I am Melanie Avalon. Vanessa is a ketogenic girl. And the show notes will have a transcript as well as links to everything that we talked about. And that will be at ifpodcast.com/episode392. Right. I think that is all the things. Anything from you, Vanessa, before we go.

Vanessa Spina:
I had such a wonderful time. I love all the questions as always and looking forward to our next episode. Likewise!

Melanie Avalon:
I will see you next week. Okay, see you then. Bye. Bye. 

Melanie Avalon:
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by Podcast Doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Vanessa: ketogenicgirl.com

Original theme composed by Leland Cox and recomposed by Steve Saunders.

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts - it helps more than you know! 

 

 

Oct 14

Episode 391: Special Guest Masey Hammons, The Fasting Evolution Journey, Balanced Diets, Fasting On The Road, Biohacking, Protein Sparing Modified Fasts, Mounjaro, And More!

Intermittent Fasting

Welcome to Episode 391 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Vanessa Spina, author of Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

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SHOW NOTES

BUTCHERBOX: For a limited time go to butcherbox.com/ifpodcast and get salmon, chicken breast or ground beef—for free in every order for a whole year! Plus, get $20 off your first order!

iHERB: Get 22% off your first order with code IFPODCAST at iherb.com/shop/IFPODCAST. Existing customers get 15% off!

Masey's background, personal story

Finding fasting, then clean fasting

The evolution of Masey's fasting journey

The Melanie Avalon Biohacking Podcast Episode #138 - Maria Emmerich

Go to Melanieavalon.com/ketoadapted and use the coupon code MELANIEAVALON to get 10% off Site Wide!

Alcohol with a fasting lifestyle

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Being on the road in a healthy way

Changing lives

Mounjaro (GLP-1 agonist)

Episode 388: Special Guest: Dr. Naomi Parrella, Weight Loss, Fat Loss, Semaglutide And GLP-1 Inhibitors, Fasting With An App, Muscle Loss, High Protein Diets, And More!

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TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.) 

Melanie Avalon:
Welcome to Episode 391 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of "What, When, Wine" and creator of the supplement line AvalonX. And I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of "Keto Essentials" and creator of the Tone Breath Ketone Analyzer and Tone Lux Red Light Therapy Panels. For more on us, check out ifpodcast.com, melanieavalon.com, and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Melanie Avalon:
Hi, everybody, and welcome. This is episode number 391 of the intermittent fasting podcast. I'm Melanie Avalon, and I have a very special guest here today. Friends, I am so excited about this. So we're going to try something new on this show where we start interviewing you guys about your intermittent fasting journeys. The idea came up because we get just such incredible questions. And honestly, a lot of times, the questions that I gravitate towards are where people are sharing a lot about their life. And so I was thinking, you know what, we should just have some listeners on so we can hear all about their stories, their journeys with intermittent fasting, their challenges, their unique approaches. So I'm really excited for this. I'm actually nervous because it's like the first time I've done this format. But if you're interested, definitely email us if you would like to be on the show. And for that, just email questions at ifpodcast.com. And then I think we also have a submission link form as well that I can put the show notes. But in any case, so today's guest, the first in this lineup, I am here with Masey Hammons. And friends, she submitted her story to us. And I have a lot of questions because I don't even know where to start. First of all, Masey, you have like a really cool job. Can I just say that? Yes, absolutely. So I'm dying to hear all about that and how you integrate intermittent fasting into all of that before that. So we were just talking offline. And so you live in Louisiana.

Masey Hammons:
Yes, that's correct.

Melanie Avalon:
A few hours from New Orleans.

Masey Hammons:
Yeah, so I'm about two and a half hours away from New Orleans, an hour from Baton Rouge. So I live in a smaller university town in Louisiana.

Melanie Avalon:
Super cool. Would you believe I actually haven't been to New Orleans ever?

Masey Hammons:
Based on the way that you talk about travel, I feel like New Orleans would be like extra anxiety for you. But if you ever come, I will be your tour guide.

Melanie Avalon:
Oh yay, I feel so seen and understood. Do you go much, being sort of close-ish?

Masey Hammons:
So my future husband, his family is actually from New Orleans. So we go to visit them and my father lived in New Orleans growing up as well. So we take our time to go to the city, but we usually do the non touristy things.

Melanie Avalon:
Yeah, I was going to ask because like when I think New Orleans, I think I think two things I think maybe I think three things I think partying. I think drinking like outside. Absolutely. And I think ghosts like haunted stuff.

Masey Hammons:
Oh, okay, so this is a first because you didn't save Mardi Gras.

Melanie Avalon:
Oh, that too. My runner-up was going to be like something related to food. Yeah, no, Mardi Gras, that too. Non-touristy stuff. Is that just like restaurants? Or like, what is the non-tourist version?

Masey Hammons:
So there are actually a lot of really cool places in New Orleans that are very historical, being like a southern portion of the US. We're so intertwined of Spanish and French culture because we were kind of flipped back and forth. So there's tons of properties that you can see. We have a rich museum district downtown. And I really just like being in the French quarter. It's so old and it kind of feels like home and special when you're there. So you can find anything you want downtown New Orleans.

Melanie Avalon:
I love it. Okay. So maybe, maybe I will go sometime and we're going to have to circle back later. I'm really curious in your eating window what you would eat in New Orleans. Okay. But in any case, so I mentioned your job. So you are, you're a director of forensics for a university speech and debate team.

Masey Hammons:
Yes.

Melanie Avalon:
What does that even mean?

Masey Hammons:
my students compete in competitive performance and debate events. So think about speeches that they would give poetry, prose performances, dramatic monologues, and they also do debate styles. So I got involved when I was in high school. I really found myself, my voice, my advocacy. I had an amazing female coach who just taught me that I could be anything in the world, regardless of where I came from. And so when I went to college, I thought I want to do that too. So I got my master's, started coaching a collegiate team. And then when I finished my doctorate, I was coaching again. I took a little break, and then I've been back for a couple of years now. And I have to say, it's one of the most rewarding jobs to see young people being advocates every single weekend and really standing up for the things that they believe in and spreading the message that they feel like is most important to them.

Melanie Avalon:
I am so fascinated by this and in particular because I feel like when it comes to language and grammar and things like that, you know, there are certain paradigms and structures and you don't see them until you learn them and then you see them everywhere. So I'm super curious, like, do you filter the world and conversations that people have? Do you see them differently through kind of like a debate lens, especially in today's culture where people are like arguing about everything all the time?

Masey Hammons:
Oh, definitely. You could not imagine the number of people who find out what I do and say, well, I want to debate you. My whole platform is, I really don't mind wherever you land on the spectrum, you know, the political spectrum, religious spectrum, any of those things. It's really about we should all learn to be able to communicate with each other in a way that's fact based, that's ethical. And, you know, with social media and all of those things, we don't get a lot of that anymore. So that's really what I teach my students to do on the team and in my university classes. And that's the kind of person that I try to be so that my students see an example of what it looks like to be able to talk with people who don't necessarily believe the same things that you do.

Melanie Avalon:
That's so incredible, because I think, at least for me, I think the first thing I think when I think debate is I think, oh, trying to win an argument. But hearing what you're saying, it's more about, like you said, finding the facts and actually communicating about what you believe in. I guess being, well, that's a question. Is it also about being open to change if you realize the other person is correct or do you stick to whatever you're trying to debate when you're having the debate?

Masey Hammons:
Inside of the debate round, you stick to it, but outside of the debate round, of course, we change our mind when we're presented with the right kind of evidence.

Melanie Avalon:
Love that, okay. And the actual topics, how often, what do they involve and how often do they involve health-related topics?

Masey Hammons:
actually quite a bit. So the type of debate we do, it's called IPDA. And our students get five topics on a slip of paper 30 minutes before the round. And they go through a procedure called striking. And so between the two competitors, they end up with one topic, it could be a metaphor like the grass is greener on the other side. It could be something like football, like pop culture, anything that's happening. It could also be like environmental health care based policy. So it's like a very broad range. And it's up to the student to try to steer the debate towards their strengths. So that way they can come out with the win.

Melanie Avalon:
That is so cool. Okay. I love this. I'll probably circle back to it a little bit more, but getting into your personal story. So we have a little bit of a color picture of your life with what you wanted to do with your passions and all of those things. What was your health journey like during that, especially when it comes to weight and dieting? What was the journey there?

Masey Hammons:
Kind of like you mentioned, when people think about the South, they think about food, right? So for my whole life, everything that I did, my culture and my community was all about food and drinks. At breakfast, we talked about lunch. At lunch, we talked about dinner. It's this entire social experience surrounded by your family and friends. And in this culture, we don't always think about what is healthy or what we should be doing. And that gets away from you very quickly. And so as a kid, you can keep up with it, right? You're active. You're doing other things. But as you become older, you realize that, hey, maybe I don't really know what healthy eating looks like. And maybe I haven't learned enough about what my particular body needs. So I started on the journey, like most of us, in college. But I found that no matter how much I exercised or changed my diet, things just weren't working for me. And so it got to a point where I ended up meeting a fabulous endocrinologist. And his dietician gave me some homework. And that homework was to listen to your podcast.

Melanie Avalon:
This is crazy. That's crazy to me.

Masey Hammons:
Oh my goodness. Me being the studious person that I am, I went home and I started listening from number one and I listened until I caught all the way up. And that's when it really hit me, like maybe I'm thinking about this the wrong way. And so working with that endocrinologist and starting intermittent fasting, and just as that developed into some keto strategies, sometimes I do PSMF, it just, it really changed my life. So in 2022, when I met the endocrinologist, I was about 260 pounds. And when I went to the doctor yesterday, I was about 174.

Melanie Avalon:
That's amazing. Congratulations. Thank you. Do you still work with that dietician?

Masey Hammons:
So they're still at the office. I don't have to see them anymore because I got a gold star, but I still do see the endocrinologist every few months just to monitor because I have some things going on in my body that were really holding me back. And then once we identified those like PCOS and metabolic syndrome, then that's when we were able to really like start moving the needle forward.

Melanie Avalon:
You were talking in your form about how you also have been able to go off of some of your medications as well?

Masey Hammons:
Yes. So I have been on high blood pressure medicine since I was 22. My dad had his heart attack when he was 40. His mother, his father both had heart attacks very early on as well. And so that's been a fear my entire life that that's in my future. And I was able to go entirely off of the medication. And ever since then, so about a year and a half now, I've been rock solid. I've also been able to get rid of some of the other medication for like fatty liver disease and other things. So it's been really exciting.

Melanie Avalon:
So when you first, I'm really curious if you remember, so you went in, you got your homework about listening to our show, which, oh my goodness. I can't even imagine what our episodes were like in the beginning. It was so long ago. That was like 2017 or 18. I'm curious, how long did it take you to decide to try intermittent fasting? And like, was there any one thing that made you decide to try it? And was it like a quick decision or did you have to think it over? Do you remember, you might not remember.

Masey Hammons:
Totally do.

Melanie Avalon:
Okay, so what was that like?

Masey Hammons:
I saw the endocrinologist and then two weeks later, I saw his dietician. So the endocrinologist said, you're going to do intermittent fasting. But like most doctors, he just said, you're going to fast. I want you to fast for 16 hours, eat for eight. And that's it. That's all he gave me. And then I went to the dietician after trying to fast for two weeks. And as you can imagine, I was doing it terribly. I was having bone broth. I was doing, yeah, I was doing all the things that are like not allowed. And so then they gave me the podcast and I listened to those episodes where you and Jen were like, this is how you do it. And after that, I was like, this is amazing. It fits so well into my lifestyle and it wasn't a struggle anymore. And to this day, I mean, we bop around, you know, flexible based on what I'm doing, if I'm traveling. But most days we're fasting 16 to 20 hours a day still, even when we're doing other styles like PSMF.

Melanie Avalon:
Wow, and by we, you mean you and your fiance? Oh!

Masey Hammons:
Oh, yes. Oh, so he's doing it too? Oh, yeah. So I will say, so for him, he doesn't have any medical conditions, but just regular fasting for him, like it was a struggle because we had to figure out what fit. And then once we started trying PSMF three days a week, that was like worked for his body. So he was not really overweight. So he didn't have a lot of weight to lose, but he's lost about 20 pounds.

Melanie Avalon:
Oh my goodness, so many keywords, I'm so excited. There's so much to talk about here. I find it so interesting that the doctor, on the one hand, it's really nice that he's recommending fasting. That's really nice. It's also really interesting. It never really occurred to me. Honestly, I don't think in the entirety of this show, I haven't contemplated how a doctor might recommend it but not give any context really. And you're kind of just on your own. Yeah, that would be really confusing, I imagine. And just for listeners, I mean, listeners are probably familiar, but when you said you were doing all the things wrong, so like bone broth, were you having, what else were you having during the, quote, fast?

Masey Hammons:
So at the time, I was a high school teacher, so I had to be at work for about 620. So at 620, I would get to work. I would make a cup of bone broth, and I would drink that until it was time to eat lunch. But also, we didn't even think about things like gum or mints or other stuff like that. I was like, oh, no calories. It's totally fine. I was drinking tea that had things in it, like natural flavors. All the things that you do to get you through the fast before you know that it could be easy if you just didn't do those things.

Melanie Avalon:
It's interesting because I feel like in the evolution of this show, I've had three co-hosts now and everybody has their own passion. So I feel like when I was with Jen, she's all about the clean fast, so we were talking about that all the time. And I'm just thinking right now how we haven't talked about that a lot recently. Vanessa is more about the protein, and so that's a common topic. And then with Cynthia, it was a lot about, well, she loves protein too, but that was a lot about hormones. So I'm just thinking about how with the clean fast concept, how we used to talk about it all the time and don't that much anymore. So I'm glad we're talking about it now. It's interesting because for me, and I've talked about this on the show before, but I didn't start with clean fasting for a long time either, and it did work for me. And so I know for some people, it's hard for me because I know it can sometimes work as a training wheel for people getting their way in, but then I just know it's so much easier when you do the clean fasting. And for some people like you, it sounds like it was just not working. Do you remember like, were you pretty hungry?

Masey Hammons:
Oh, I was white knuckling it the whole time.

Melanie Avalon:
Yeah, so it's so interesting, you know, with different people how, again, I, but I wasn't doing bone broth. I think that would, that would probably really kept me hungry. I mean, that's literally like nutrients, literally food. Okay. So once you finally got into the groove of the fasting approach that worked for you, you mentioned, I definitely want to talk about PSMF, but you mentioned keto. So your food choices surrounding this, did you make what, what were, and you also talked about, oh wait, I want to comment on that really quickly. The South, I also am from the South as you know, and yes, the food here is just, it's just not the best for health. It's like kind of shocking. I, like when I see it, I'm like, it's not surprising to me that we have, you know, so many challenges today with, you know, weight and the obesity epidemic and everything. Just like, look at the food that we're surrounded by. So your food choices, did you make any changes to what you were eating before that? So like, what were you eating then when you first started?

Masey Hammons:
So the weird thing about this is that I was one of those people who was already eating the balanced diet per se, making sure that I was having the protein, the healthy carb, and the vegetable. I was doing all the things right, but I wasn't seeing any difference. And I think that had a lot to do with the fact that we don't understand a lot about calories in, calories out, or all those things that we tell people to do and they'll be fine. And so my journey sort of changed as the evolution of your show happened, because I was listening to three or four episodes a day to catch up. So in the gin era, I focused on the clean fast. And so I stuck to the things that I was already eating, a balanced diet, making sure we were reducing things that we shouldn't have. And then when we got into the Cynthia era, I found a functional practitioner and added them to my team. Oh, wow. Wow. Yeah. And so that really changed the way I started thinking about supplements and my insulin resistance. And that's when we had more of a focus on what was actually happening metabolically in my body. And so then we did Cynthia's 45 day transformation. Oh, you did. We did. And we loved the food and it was, it's more of a focus on higher protein and just better complex carbs if you have them. And then as we got into the Vanessa era, which now I just feel like I'm hanging out with my girlfriends, right? Because you and Vanessa are like my age. So now I'm like, Oh my gosh, all this information about protein. And then that's how we found PSMF. So my diet never really was terrible to begin with. But if I look at the beginning to now, like we mostly focus on our protein goals. Now we don't eat a ton of fruit or any of those things that we were considering was okay before. And we've had some real conversations with ourself about whether or not like alcohol is worthwhile, you know, especially here in the South, you could drink every day if you wanted to, you definitely have the opportunity with all the social occasions. And so we started asking ourselves what kind of life we wanted and what we wanted our longevity to look like. And so now I'm in the era of body composition and just doing the things that are going to keep me here and healthy the longest.

Melanie Avalon:
This is awesome. I'm going to text Cynthia after this and tell her about that. That's so great.

Masey Hammons:
Oh, yes, please.

Melanie Avalon:
Okay, I'll tell her hi from you. That's amazing. And when you're talking about the eras, I'm like, I need to have like, it's like the Taylor Swift eras tour. I need to have like the eras of the show. That's so funny. Clarifying question about your fiance because you talked about him doing it. What made him first decide to do it? Did he see your success and just want to like, try it to come along? Or what was our conversation there? Did you want him to do it?

Masey Hammons:
So he is one of those people that will not let you go through any journey alone. And so when I came home from the doctor, the first question he said was, what do we need to do? And this was before we had, you know, this was the beginning. And so every single time that I have had something change for me, he's been 100% on board. And he says, okay, let's, let's meal plan and let's go to the grocery store. And he's always in. So I think that's probably why I decided to marry him.

Melanie Avalon:
I'm curious, when he started doing it, did he expect one thing and then it was another thing or did he expect for it to be, you know, great for him?

Masey Hammons:
I don't know what he really expected, but he also kind of was like, I'm a little bit older and I want to be around for my kids, for you. And so he really got into the biohacking aspect of it because also I started reading Dave's books and all of that stuff. So he got more into the heat cold plunges on a pretty regular basis. And so we found a gym that offers a lot of that stuff. And so he got into that aspect. Like we bought a vagus nerve stimulator last night because functional practitioner recommended it. So yeah, so he's just, he's always willing to try and he's just happy to be along for the ride.

Melanie Avalon:
So cute, when's your wedding? Do you have it planned?

Masey Hammons:
Oh, I do. It's December 14th. I actually just took my bridles.

Melanie Avalon:
Oh my goodness, that's so exciting. Wow, that's coming up.

Masey Hammons:
Oh, I'm definitely going to send you a photo because I'm a non-traditional bride. I don't want to give any secrets away, but I'm going to send you and Vanessa the photos so that you can see. It's going to sound weird, but my wedding is actually dinosaur themed.

Melanie Avalon:
Oh my goodness. Wait, this is so cool. Okay. That's cool. I love that. I love when people do things like, cause everything, I mean, I love weddings in general, but dinosaur themed. So is your dress going to evoke that a little bit?

Masey Hammons:
It does, and I took my bridal photos in a paleontology exhibit at a museum.

Melanie Avalon:
Oh, oh my goodness, I want to see these pictures. Yes. Are the bridesmaids, do they have outfits?

Masey Hammons:
So we decided to go with greens. So we have a spectrum. So yeah, they all got to pick their own green and they all picked their own dress that they loved. I only have four of them, plus my stepdaughter, my niece, is our little flower girl. And she's going to be wearing this cute little golden ball gown.

Melanie Avalon:
Have you always loved dinosaurs? Is that like your thing? Oh yes.

Masey Hammons:
I also love, like, I don't want to say cult classics because I don't think anybody else loves Lake Placid as much as I do, except for my sister, but those are the movies that I like. Anaconda, Lake Placid, there's like six of them. If you didn't know that, look them up.

Melanie Avalon:
Wait, what's in like, okay, that's ringing a bell. Is that like a Loch Ness Monster thing or?

Masey Hammons:
It's an alligator.

Melanie Avalon:
Oh, it's an alligator. Okay.

Masey Hammons:
Yes. But they have about six of them. It's the only movie that I think rivals the land before time for a number of sequels.

Melanie Avalon:
Do you know my land before time story?

Masey Hammons:
that you watched number two or like number three instead of number one.

Melanie Avalon:
We had lamb before time two. So I just literally thought it was lamb before time two. Like, like, like that's the movie. I didn't realize there was a one.

Masey Hammons:
I thought to myself I wonder which one I watched because I would always watch it at a friend's house because she had it.

Melanie Avalon:
She probably had lamb before time too, if we're the same age, honestly.

Masey Hammons:
We're close. I think I'm older than you, but only by a little bit.

Melanie Avalon:
Okay, so okay, so might have been before we might have been number one. That's so funny. I also have this and I won't go on this tangent forever. But speaking of alligators, I saw this movie when I was little, I don't think I was supposed to be watching it, but I did and it scarred me for life and I had an alligator and I always thought it was alligator, but like the movie alligator, but maybe it was like placid. You'll probably know the answer in the beginning, the way the alligator got where it got was because the kid flushed it down the toilet.

Masey Hammons:
Oh no, so that one is actually when the alligator lives in the sewers.

Melanie Avalon:
Yeah, yeah, yeah. Is that alligator? Is that just like the movie alligator?

Masey Hammons:
It's something like that.

Melanie Avalon:
Yeah, I just have I should not have been watching that movie when I was like four or five. Okay, that's awesome So is your fiancee down with I mean i'm guessing he's down. He's down with this dinosaur themed wedding

Masey Hammons:
Yes, he loves dinosaurs just as much as I do. He actually is his very next tattoo. I told him no tattoos, any more tattoos until after the wedding. But his next tattoo is going to be a velociraptor, and it's going to say, clever girl. And that's for me, because I'm his clever girl.

Melanie Avalon:
Oh my goodness. That's so, that's so cute. That's amazing. Look at you guys. You would have been great in the stone age doing your fasting. You're like hunter gathering, you're existing with the dinosaurs. Wow. Okay. So back to speaking of fasting and the protein. Okay. So you mentioned that you're not doing fruit and such. So when it does come to the carbs and the keto, what has been your evolution with your relationship to low carb versus not low carb versus keto? What has that been like?

Masey Hammons:
Yeah, so I kind of got to a point where I realized that I was doing more strength training and other things. And I started to not feel my best when I added that in. And so that's when I really started honing in and listening to Vanessa's other podcast. And that's when I realized that maybe we're just not getting enough protein on a weekly basis. So that's when I started reading PSMF. And then she had Maria Emmerich on one of them. And so we picked up her book and we followed the recipes in the book. And that's when I was like, oh my gosh, I feel so much better. And so pretty much in a day for us, we'll do two meals. So we open up our fast anytime after two o 'clock usually. And that's pretty much just like chicken sausage. We do a lot of shrimp, scallops, or steak. And then for dinner, we'll do the same thing. But sometimes for dinner, if it's not a PSMF day, we'll add like the asparagus. So vegetables that are low carb vegetables. But then on PSMF days, it's mostly just the meat. And I was surprised because I didn't think I would like it so much. But that's what I find myself craving all the time now.

Melanie Avalon:
some clarification and definitions for listeners. PSMF refers to protein sparing modified fast. In the clinical literature historically, and I'm guessing it probably, I should know this, I feel like historically it probably first was a clinical studied dietary approach. It's historically very calorie restricted. You're eating, I don't know how many, like 500, 600, 700 calories of basically just pure protein. Maria, who's a wonderful soul, and I've had her on my show as well. I'll put a link to it in the show notes. I should have her back on this show actually. I think I'll reach out to her. She has kind of taken the PSMF and taken tenets from it and made it her own thing, which is basically just eating tons of lean protein. Because correct me if I'm wrong, you don't count calories with that approach, right? You just eat the PSMF foods essentially. Yeah, she has so many recipe books. So actually, if listeners go to melanieavalon.com/ketoadapted, you can use the coupon code MelanieAvalon that will get you 10% off site wide. And she does have, like we're talking about so many recipe books, it's really amazing. And she has a lot of really amazing like Instagram content and YouTube. So if this approach resonates with you, I definitely recommend checking out her work. So when you started implementing those those days, how did that move the needle in your personal goals? Like what did you see happen with that?

Masey Hammons:
So really, that's what got me over my last plateau. So I've never really been a person to focus on the number because I always feel like I have weighed a lot in the grand scheme compared to other people. And so when I was doing lifting two days a week or sometimes even more than that, depending on what my schedule looks like, I realized that I was getting stronger and I was really able to start increasing the amount of weight that I was lifting. And I'm not like a crazy gym person. I do body pump at my gym. It's a 50 minute class. It's a full body workout, which thanks to Vanessa, I now know is totally cool because she just did a study about that on one of her episodes. So I was like, yeah, I'm doing something right. But yeah, like that's what got me from just losing weight to actually focusing on body re-composition and making progress in the gym strength-wise.

Melanie Avalon:
I love this. I will also text Vanessa after this and tell her that. All the texts are incoming. Yeah, it's really interesting with the PSMF because as I'm sure you're familiar with since I've talked about this so much, but my first dietary hack, well, my first like kind of rogue crazy dietary hack that I tried myself was when I had the epiphany like a decade ago, I was like, oh, I could basically eat just lean protein and not probably gain any weight and probably lose weight and feel really full. And that's why I went through this period of time, which I'm not recommending. This is like an ongoing dietary approach, but it's basically the PSMF approach. I kind of like found it on my own just like by thinking about it, just thinking like, okay, all the options of what we can eat, like what would the metabolic effects be? Oh, let me try eating just tons of lean protein. And I do think so again, that's it's not sustainable. It's not meant to be an ongoing, like a daily thing. But as you experienced, there's a lot of metabolic magic to it. And it's, you know, super protective of muscle. So I think it can be a great hack and a great way like you said to break through plateaus, speed up weight loss, you know, depending on where you are at your journey, I think it's a really nice tool to have. And what I love is this approach because a lot of people when they hear it, they might think severely calorie restricted PSMF because historically, like I said, that is what it is. But when you take this Maria Emmerich approach, you don't even have that with it. You get to just eat all the things. Pretty much. What's your favorite PSMF food to start with that?

Masey Hammons:
This one surprised me, but I make Maria's bread, so it's... Yeah. Her cloud bread? Yes. I make it by the loaf every other week. So every other week, that's our food prep for the three days that we do it. And I'm not a huge bread person, like a sandwich bread, but I would eat that bread every single day of my life, whether I was doing PSMF or not. It's delicious.

Melanie Avalon:
Oh my goodness. And how do you make it again? I've watched, I've looked at the recipe a lot, I've watched her make it. It's like egg whites, right?

Masey Hammons:
So it's really easy. It's egg whites. And then if you live somewhere like us where it's humid, you should use the cream of tartar. But if you live somewhere less humid, you might not have to use it. And then egg white protein powder. And that's pretty much it. You let it whip. And then you put it in your loaf pans. You bake it in the oven for 45 minutes, and then you let it sit for like an hour. Then when you take it out of the oven, you let it sit for a couple more hours. And then after that, it slices like regular bread. And we keep ours in the refrigerator. So we slice two slices and pack it in parchment paper. And then in a separate container, we pack our ham and our cheese, whatever we're having with the sandwich. And then that's it. It's the easiest meal prep for three lunches in a week.

Melanie Avalon:
That's amazing and I'm actually surprised I haven't made it does it taste like bread it does

Masey Hammons:
And we've even, so we made it cinnamon rolls out of it. We watched a video and I was like, I don't think it's going to work, but we did that. We've also turned it into croutons. We've made the flatbread and the hot dog buns. It's more versatile than you would think. And like, again, I thought it was going to be disgusting, but it's wonderful. I love eating it.

Melanie Avalon:
You mentioned the cinnamon rolls. Do you ever make dessert-y type things?

Masey Hammons:
Sometimes we so the one thing about forest is he's a snacker. Oh his name is

Melanie Avalon:
forest I love that and he loves the dinosaurs and you guys this is amazing

Masey Hammons:
Yeah. So if I make anything like that, we'll eat it too quickly. So a small serving of something that's sweet, it's not going to happen. So we try not to do things like that, just for special occasions, especially when we have our kids over. Well, our kids, they're forest kids, but they've been troopers because they come over and they eat the food that we make, and they are excited to try things. So our sweet little Luna, she came over when we made the cinnamon rolls, she helped me make them. And then I think she ended up having three servings of them because she loved them so much.

Melanie Avalon:
Oh my goodness. That's amazing. I love it. I love it. Well, again, so for listeners, definitely go to Melanie Avalon dot com/keto adapted use the coupon code Melanie Avalon. That's where all of Maria's recipe books are. And I'm pretty sure she has like dessert recipe, like she has a lot of different books with different, you know, topics depending on what you want to be cooking or baking. So the alcohol piece, I'm curious what type of drinks do you gravitate towards? And have you ever tried a clean alcohol approach?

Masey Hammons:
We are the kind of Southerners that have a full-on bar in our house, so it's in our parlor, we call it the parlor, and it's got just about everything. Forrest was in the restaurant industry for a long time. He was a bartender. So when we drink, it's typically cocktails. Those are the things that we gravitate towards. My favorite drink is like an espresso martini. I love coffee, and so the two pairing together is my favorite. And so one of the things that we started substituting were easy things. So instead of making a regular margarita, we were using the element and sparkling water.

Melanie Avalon:
I interrupted you so do you for that it's is it the lime element that you use we actually like the

Masey Hammons:
mango chili one.

Melanie Avalon:
Oh, okay. That's cool. That makes sense.

Masey Hammons:
Yeah, so we've tried the lime before, but the mango chili, because it makes like a spicy, especially if you like mezcal or something like smokier. Yeah, but we also like, we'll do the watermelon flavors during the summer with sparkling water, and then maybe like vodka. But yeah, so when we were going to friends houses, that's what we started packing. So instead of bringing things with lots of sugar, we were still drinking the alcohol, but substituting. And then now at this point, we are pretty much just, we're going to have the beverage that we want. We're just going to do it less often.

Melanie Avalon:
Okay, so for you, at this point in your life, you would rather have, yeah, like I said, like you literally just said, so rather than like an ongoing making these adjustments, you'd rather have like the like the add espresso martini that you really enjoy and having it less. Yeah, I love hearing people's different approaches to alcohol and how it affects their weight loss journey or not or their health or not. And I was actually literally talking about it yesterday and I was getting interviewed on a podcast and we were talking about it. Like, have you noticed an impact on your health and weight loss journey with it?

Masey Hammons:
I really have, and it's not even just about how I feel long term. It's about how I feel in the short term after that happens because that alcohol can affect you for like two or three days. And so if we were drinking and then I had something important the next week, I would realize like, hey, I don't quite feel like myself. I have a little bit of the brain fog. I don't have as much energy. And so I really started adjusting when I was going to have a drink and what was after that and whether or not that was worth it.

Melanie Avalon:
Yeah, that that completely makes sense. And like for me, I can't have any of and I've talked about this at length on both shows, but I I know it works for me, which is just basically like dry firm wine. So low alcohol, low sugar, organic wines. I mean, basically, that's that's all I drink. And then when I go out, I try to find the comparable as close as possible to that that I can. If I were to drink, I don't remember the last time I had a mixed drink. I think if I had like an espresso martini, that would probably just wipe me out. Like I don't even know. I don't remember every now and then I'll like taste if my if I'm with somebody out and they have something. But yeah, and generally stick to the wine. So oh, and for listeners, if they're interested in element, you can get a free sample pack and it will include I believe it includes all of the current flavors. So you'll get to try that. What was the what was it a chili flavor that you have mango chili, mango chili, and it should include mango chili, it should include watermelon, lime, all the things. The only one that's clean, fast friendly. So to have during the fast is the raw unflavored. But this is my favorite electrolyte drink mix ever. You can go to drinklmnt.com/ifpodcast use the actually no, I think it's automatic. So drinklmnt.com/ifpodcasts and that will get you a free sample pack with any order, I believe. Okay, other things. So so that's the food stuff. As far as the actual challenges with intermittent fasting, because it sounds like you've really settled into, you know, an approach that really works for you. A few questions there. One, how often do you switch it up the the time windows and historically, how much have you switched it up?

Masey Hammons:
So we're probably switching it up. So the three days a week that we do PSMF, we're breaking our fast probably around noon. And then we have dinner around 6. And then on the days that I'm not doing PSMF, I'm fasting longer. And on those days, I might actually only do oat mad because I may not be hungry or I'm comfortable just getting the amount of protein that I want that day in the one meal. It's a lot harder to get more protein in that one meal for me anyway. And then when I'm traveling, so with speech and debate, we travel from a Friday through a Sunday. So we compete on Saturday and Sunday, primarily sometimes Friday, Saturday, Sunday. So what I'll do is when we leave Louisiana, we compete mostly in Texas, we have a rule. How far is that? So like this weekend, we're going to Texas State. So it's about six hours.

Melanie Avalon:
Oh, wow. How big is the team?

Masey Hammons:
So my team has about 15 kids, but I travel with just a van full at a time. So we try to make it so that everybody can travel to at least one tournament a month. But I travel to all of the tournaments each month.

Melanie Avalon:
Wow.

Masey Hammons:
Yeah, so I'm about I'm heading into my streak. I'll be gone this weekend next weekend and the next weekend all in Texas

Melanie Avalon:
What? You're going to go back and forth? Yes. Does it feel the more you do it to take less time to get there? Like, or does it still take seem to take a really long time?

Masey Hammons:
My team has a really good routine. So they know that once we get in the car, we're not going to stop until we get to Bucky's, which is like in the Baytown, Houston area. And so that's when so we fast until that point. And then that's when I have a meal because Bucky's has this like everybody fast the kids to some of my kids, they do because on the way we listen to your show. Oh my goodness. That's crazy.

Melanie Avalon:
That gives me like a new perspective of who I'm speaking to sometimes.

Masey Hammons:
It's become a joke and so the kids try to see how many times they can get me to say intermittent fasting in a weekend. So now a lot of times I say I F and I'm like tricked you. But yeah, we either listen to your show or Vanessa's show. Then when we get to Bucky's, we have our snacks at Bucky's and Bucky's is if you've ever been to one, you can actually eat pretty well at a Bucky's and not have a ton of stuff. Like they even make zero sugar beef jerky.

Melanie Avalon:
Oh, wow. So what is it? Is it a steakhouse? It's a gas station. Oh, okay. Yes. Yes.

Masey Hammons:
It's a social phenomenon. Their mascot is a beaver. I've heard of this.

Melanie Avalon:
I've probably been, oh, but O-B-U-C dash E-E. Yes. Okay. And it's like massive. I've probably been to one.

Masey Hammons:
Yeah so we spend about thirty minutes there everybody gets something to eat and then that's it we get our gas we get our food and then we had to our location and then we have a nice dinner and our team has a rule that we can't eat dinner anywhere that we can eat at home.

Melanie Avalon:
Mmm, that's cute. I like that. That's a good rule.

Masey Hammons:
Yeah, it's worked out for us and so because of that, my kids do a great job. I say kids, they're young adults, but they're kids to me. They will always find these really great like farm to table options. We always try to find somewhere that also has like gluten free options for some of our students. My kids are, they're really progressive eaters, much more than you would think of a normal college kid. And so because of them, like we've had some amazing meals while traveling. And then on Saturday and Sunday, I'll do sparkling water with instant coffee, which sounds terrible, but it's really delicious. And that I will pretty much fast until the end of the tournament that day, which is around five or six o 'clock. Then we do our award ceremony and then we go to dinner and we same thing. We try to find something that is quick, but also has a ton of options. So we'll usually end up at like a waffle house or something where you can just get eggs. And then we do it all over again the next day.

Melanie Avalon:
I just had like a meta moment realizing are you going to play this episode on one of the trips?

Masey Hammons:
Yes, I am. Hi, guys. Oh, no, no, we have a group chat. And as soon as I got your email, they were the first people like I didn't even tell forest first, I told my kids. So they all know that they're not allowed to text me right now, because this is I'm, I'm in the dark zone, but that I'll be back with them this afternoon. So yes, we have a full plan to have a listen party once this comes out.

Melanie Avalon:
Well, I hope the listen party for everybody, for you guys listening right now is going really great. Thank you. That's awesome. I'm speaking to your future self. A fun fact about Waffle House, apparently, did you know they are the number one producer or seller of steak?

Masey Hammons:
I can buy that because when I go, I get steak and eggs there.

Melanie Avalon:
Yeah, who knew like most people would think it'd be like a chain steakhouse, but nope waffle house That's so amazing. So do you anticipate changing your window? Have you kind of settled into this routine?

Masey Hammons:
I think at this point, it really depends on like summer versus winter, like if you're a teacher, that's kind of the thing. So during the winter or the academic season, I have pretty much the same routine. So Monday through Wednesdays, PSMF, Thursday and Friday's regular intermittent fasting, and then Saturday, Sunday, just depends on whether or not I'm traveling. And then during the summer, when we're more social, we're spending more time at the gym, at the pool, those things. That's when we're more like we're just going to go with the flow of the day and figure it out as we go.

Melanie Avalon:
Do you find being the debate teacher, do people want to debate you about fasting?

Masey Hammons:
all the time.

Melanie Avalon:
Oh man.

Masey Hammons:
do you sometimes yes so the the wonderful thing about this is you have this whole extra following of people who've never heard your show and it's just because i will text people and be like oh you asked me about something and they talked about it on the podcast today here's the information and i do that all the time so i have all of these friends who either engage in some sort of fasting or have increased their protein based off of the studies we've been hearing about on Vanessa's show it's really trickled to so many aspects of my life and i find that even the people who aren't listening with me like you're changing their life too so i hope you know that

Melanie Avalon:
Oh, thank you. And thank you for sharing it with people. That's really amazing. Yeah, I just imagine people probably want to engage with you on the debate side a lot. So one other thing that I'd love to touch on, and we talked about this before and you talked about it in like the submission form, but so you are currently on Manjaro, right? Yes. And for listeners, that is a GLP1 inhibitor that people talk about a lot. So why did you first go on it?

Masey Hammons:
So when I was meeting with the endocrinologist, one of the things that we learned and the functional practitioner really helped with this too, is that I have PCOS and with that comes metabolic syndrome. And then I had already previously been diagnosed with fatty liver disease. So in the genetic lottery, I like hit the lottery in a bad way. It was really, my body has been working against me for a long time. After doing just intermittent fasting for a long time, my doctor was still seeing that my numbers just weren't where we needed them to be. So we kind of started with metformin. And then once I started that, we noticed that it started to get better, but again, still we weren't seeing the kind of results that you would expect for somebody who is fasting and is taking metformin. So the first one we actually tried was Ozimpic. And it worked okay, but I will tell you of the two, Ozimpic kind of makes you not feel great. And for me, Monjoro just sort of slides into my daily life. I don't really notice the difference. And so once I started on the Monjoro and I've been on that for about a year, my fatty liver went from a stage five to a stage zero one. Wow. Yeah, so, and that's like one of the things that I think people don't realize is there are a lot of things that these GLP ones can do in a body that's not metabolically functioning well. And there are so many things about it, like the wellness clinics, all that stuff. So I know it's controversial, but I try to set that aside and remind people that we don't always get the bodies we want. So we have to work with the bodies that we have. Once that became a part of my life, it didn't even really change the pace that I lost weight because I was losing weight just doing the intermittent fasting alone. I lost probably about 35 pounds before I ever started a GLP one, but it changed the way that my body could function. And when I went off of the GLP one, switching from Ozimpic to Monjoro, I didn't change my diet. I didn't change my fasting pattern. I was still going to the gym and I gained 15 pounds in three weeks.

Melanie Avalon:
Oh wow, from Osundweg to Manjaro.

Masey Hammons:
Yes, and it was purely because whatever the GLP-1 does in my body, it helped it maintain the weight loss. So really for me, the GLP-1 is about my insulin resistance and my fatty liver disease, but it makes my body function on just a better level.

Melanie Avalon:
I'm really excited to talk about this and I called it a GLP-1 inhibitor. I mean, GLP-1 agonist, what I find really interesting about it is a few things. It's really nice to hear that you have had really beneficial effects on the fatty liver and such from it. I like hearing that because I think they get kind of demonized a bit because of how people are abusing them sometimes for weight loss. What I find really interesting about it is they are such effective pharmaceuticals. They seem to be the first thing that has come out where people are actually losing weight and making changes. And at the same time, I have all of these concerns because people do seem to be losing muscle and things like that. But my biggest question is, I don't know. And I did recently, I'm not sure which episode, I'll put a link in the show notes, I had on the doctor who is the head of the Zero app right now. And we talked a lot about this, listeners can check out that episode. But I think a lot of people lose muscle. And I do wonder how much of that is the actual drug versus they're just not eating. Because if you're just not eating, especially not eating a lot of protein, you're definitely going to lose muscle. So it's nice to talk to you and hear your experience. So even with any appetite effects from it, it sounds like you always are really focusing on protein. Is that the case, like with what you're eating?

Masey Hammons:
Yes. So even part of my routine, I have Vanessa's protein in my coffee cup right now. So I have that and I have a chocolate caramel element in there and then my coffee. So for me, one of the things that I talk about a lot, listen, in my life I could think about 10 people off the top of my head that I know that go to a wellness clinic and get an injection. And I think the hard part of and it's the thing that most people worry about, especially people like you and I who know a lot of the research is what happens when you have to get off of it and you haven't been given the tools to make a lifestyle change. Like if my endocrinologist had put me on it and never sent me to the dietician, I would have never found this podcast and other ones that have taught me how to live a healthy lifestyle. I hope that one day my body can figure it out and I don't have to be on it forever. But when that day comes, I want to know that I have all the tools to continue living my life in a healthy way with everything that my body needs. And I think that's the struggle because not a lot of people are getting that in these wellness clinics. They get the, here's the thing. They eat less, but they don't stop drinking or they don't realize that they need more protein. They're not working out because they're tired because they're not getting enough protein. So it's this really strange cycle, but I think it's indicative of our pharmaceutical industry and our medical industry, which is like a whole other conversation. But it's definitely interesting because a lot of times I will have friends reach out and ask questions like, Oh, I know that you are on Monjuro. I need some help. What should I be eating? What should I be doing? And again, like that is also how you and Vanessa are affecting so many people in my life because I'm sharing the information that you guys are giving me. So that way I could try to help people make healthier choices and transition a little bit better.

Melanie Avalon:
I do think that that transition period when people are going off of it is probably so key, and I'll be really curious. You'll have to keep us updated if you do ever go off of them, you know, what that experience is like for you and what you what you do experience. We're seeing so many beneficial effects with weight loss with people on them. It would be so amazing if everybody could approach it the way you're approaching it, because I think that's the closest we could get to getting, you know, the most benefits with the least side effects that might be problematic. So yeah, exciting. Oh my goodness. Is there anything else in your fasting journey that you would like to share with listeners, anything that you think people should know about intermittent fasting from your experience?

Masey Hammons:
I think the number one thing from my experience is that we call it a journey because that's really what it is. You know, and other people know, we all start our health journey a long, long time before we ever find intermittent fasting. Once you get there, you're so fatigued from doing all the other things, from following all the other diets and whatever's popular at the time that if you're not careful, intermittent fasting can feel like one of those things too, like a fad. And if you only give it a couple weeks or even just a couple months, you might not really ever get there. So I would encourage people to really stick it out and, you know, read the information and figure out how to do it correctly and what works for their body. Because once you do and once it clicks, I can't imagine living my life any other way than this. And just a silly little thing that happened today. My mom called me before this, she wanted me to meet her and my aunt at the store to go shopping for some clothes for the wedding. And we saw this beautiful dress and my hair is purple right now. Oh, cool. Yeah, it's always some color, it's purple right now. And we saw this beautiful plum dress and it is a size six. And I said to my mom, I cannot fit into that. I will never fit into that, like that's not my size. And she said, go try it on anyway. And I tried it on and that little baby fit. And I think I almost cried in the fitting room because it's not really about the size, but it's about the fact that I could have never imagined feeling this healthy and fit in my life ever. And that's coming from a person who was an athlete in high school who has always gone to the gym and done all the right things. And when you get to this point, the excitement, the new things that you get to experience, like buying a size you've never bought before, it's joyous. And if you could see me right now, there are tears in my eyes talking about this because this is the journey that will change your life if you let it.

Melanie Avalon:
Oh, my goodness. Well, that is such a beautiful way to end this. And thank you for sharing your story because your story has changed. You are changing so many people's lives, honestly, like, you know, like, thank you for what you're well, first of all, thank you for having the courage that you've had in your journey and for keep on keeping on and sharing this with so many people. I'm just so grateful. And it's so, so inspiring. I so enjoyed this conversation. I can't wait for people to hear it. This is absolutely amazing. Like, just seriously, thank you.

Masey Hammons:
No, thank you.

Melanie Avalon:
Awesome. Well, I'm trying to say I feel like I should have I'm deciding this in real time I feel like I should have like a certain way that I you know, I'll end this the way that I end My other show because I think it's so important So the last question that I ask every single guests on my other show which is the Melanie Avalon biohacking podcast And it's just because I realize more and more each day how important mindset is. So what is something that you're grateful for?

Masey Hammons:
I think today, more than any other day, I am grateful for the community that I have, because in this journey, it's hard to find people that are willing to go along with all the crazy things. And my parents and Forest have watched me just dive right in, and they've never once made fun of me. They've never once criticized me. They have been okay to let me just figure it out on my own. And so because of them, I was able to stick to it. So I'm really grateful for my community.

Melanie Avalon:
I love that so much community is so so important and I think that's one of the ways and reasons that things like podcasts and Facebook groups and all of that can be so amazing in the intermittent fasting world because like social support can be a game changer into you know whether or not you can actually implement and stick to something so that's amazing about your personal community. So for listeners we will put in the show notes which will be at ifpodcast.com/episode391. There will be a full transcript, there will be links to everything that we talked about and there will be before and after pictures of Masey. So you can check those out and if you would like to be a guest like this on the show definitely submit your story. For that just go to ifpodcast.com/submit S-U-B-M-I-T and I think that is all the things. Thank you so much for your time Masey this was so so amazing definitely keep us updated on your journey and also I can't wait to see your wedding pictures and congrats in advance.

Masey Hammons:
Thank you so much. I'm so excited. This was amazing. Have a good rest of your day. You too 

Melanie Avalon:
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by Podcast Doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Melanie: MelanieAvalon.com 

More on Vanessa: ketogenicgirl.com

Original theme composed by Leland Cox and recomposed by Steve Saunders.

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts - it helps more than you know! 

 

 

Oct 06

Episode 390: Fasting For Athletic Performance, Ketosis, Overeating, Food Choice, Improving Satiety, Crash Dieting, Homeschooling, Preschool, And More!

Intermittent Fasting

Welcome to Episode 390 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Vanessa Spina, author of Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

LMNT: For fasting or low-carb diets electrolytes are key for relieving hunger, cramps, headaches, tiredness, and dizziness. With no sugar, artificial ingredients, coloring, and only 2 grams of carbs per packet, try LMNT for complete and total hydration. Be sure to try the new LMNT Sparkling — a bold, 16-ounce can of sparkling electrolyte water. Go to drinklmnt.com/ifpodcast to get a free sample pack with any purchase!

To submit your own questions, email questions@ifpodcast.com, or submit your questions here!! 

SHOW NOTES

LMNT: Go to drinklmnt.com/ifpodcast to get a free sample pack with any purchase! Learn all about electrolytes in Episode 237 - our interview with Robb Rolf!

International society of sports nutrition position stand: ketogenic diets

Listener Q&A: Brittany - Why am I not losing?

Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.

TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.) 

Melanie Avalon:
Welcome to Episode 390 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of "What, When, Wine" and creator of the supplement line AvalonX. And I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of "Keto Essentials" and creator of the Tone Breath Ketone Analyzer and Tone Lux Red Light Therapy Panels. For more on us, check out ifpodcast.com, melanieavalon.com, and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.


Melanie Avalon:
Hi, everybody, and welcome. This is episode number 390 of the Intermittent Fasting Podcast. I'm Melanie Avalon, and I'm here with Vanessa Spina. Hi, everyone. And for listeners, Vanessa and I were just chatting beforehand, and I was so intrigued that I was like, we should start recording so people can hear this. So you are thinking or are going to start homeschooling?

Vanessa Spina:
Yeah, we've been planning it for a while, and this is it. It's happening now, so it's almost September. I traditionally always started school in September, so I'm starting his preschool program, so Luca’s three. So he basically has three years until he would start school officially. So he's in the preschool years now. So I am starting with him in a few weeks, his first day of school, his first year of school. I'm trying to get him starting to warm up to the idea that he's starting school. A lot of his friends already go to school. A lot of his friends, some of his friends are starting school soon, so I want him to also have that first day of school feeling, and just getting everything ready. So I have the whole year's curriculum already set to go and everything. I'm just, I was telling you, I'm ordering all the books. So each unit that we have, you basically go through different things, like the first unit we're doing is apples. So there's lots of things related to the letter A and apples, and then you have to get all these different books to go with it. So I was ordering all the books, and I was like looking at the book list, and there's 190 books that I need to get for his first year. 190? Yeah, because there's basically a different book. One for every letter. Yeah, there's one for, so there's 19 modules. We cover all 26 letters. We're gonna be learning a lot about letters this year. Not so much like math, although I will personally add in some math, because he loves numbers. But it's not really about full -on academics yet, because he's only three. At this age, so I've been learning a lot about homeschool in the last months, because we're planning to do it with our children. As long as it's working out, like we're gonna test it with preschool, see how it goes, and if we can keep up with it, we'll keep going with it. But I'm basically learning to become a teacher at the same time as doing all the other stuff that I'm doing, but what's interesting about it, and I think what makes it workable is if you look at their ages, how much time you actually spend in the whole day doing class. And we have some good friends who do it, and for their teenagers, they do about three to four hours of full -on class, and the rest of the day, they can go, because they live in Puerto Rico, they can go to the beach, and they can go, or they can go work on their side businesses, or they can go do all this stuff. For someone Luca's age, it's about 30 minutes. So what I'm doing with him right now is preparing him, so we do a lot of reading aloud in the morning, and then he does some basic stuff, like coloring different types of fruits or dinosaurs, and then we count after how many, like it's really basic stuff, but yeah, I'm ordering all the books, and it's pretty fun, and we're getting all the school supplies, which is my number one favorite thing to do. When I was a kid, when we had to go get school supplies and go to the art supply store, it was the biggest high for me ever.

Melanie Avalon:
So, oh my goodness, like the moments. Okay, wait, cause you grew up like all over. Where were you during that phase of your life?

Vanessa Spina:
i was always in the same school system though so up until grade nine i was in a french lisa which is a french private school and i stayed in that system everywhere i went and then in grade nine i switch to the international school system which is an american curriculum and then i stayed in that in beijing and in the philippines so i was doing like a same similar curriculum to what people were doing in the us it was the same but the french school that i went to they had so many school supplies it was insane how many supplies we had to get so we would go i remember specifically being in canada to your question when we were doing this and we would go to a couple different art stores and just get everything like there were just so many supplies and so many fresh notebooks and we had even we had these like architecture classes that we would get these special stylo pens for and everything and i yeah i just loved it i loved all the school supplies the fresh books i think probably most kids like that

Melanie Avalon:
I think like the best moment was, okay, so did they have Crayola, like the brand of crayons? Yes. Oh yeah. I got that for Luca also too. Okay. So like the moment of like, how many crayons do you get? Like, do you get the one with the sharpener in it that has like all the crayons? Yeah.

Vanessa Spina:
I just love all that stuff, so it's fun to deal with him.

Melanie Avalon:
I would be so stressed because inevitably, with the list, we would just go to like Target or Walmart, but there would always be like something I didn't have from the list. And I would be so stressed about it. My mom would be like, Melanie, you don't have to have everything on the first day. And I would be like a wreck like this, like every year. I'm so rules oriented.

Vanessa Spina:
No, that's how I feel right now because it's harder to find supplies here because we don't have Target or Michaels or anything. So I have to go to these little shops, which is like, okay, that's the fun thing about Europe, right? They don't have those big box stores. They have all these cute little shops, but you have to go to all these little shops and all the little shops are really expensive because they're little shops. So I went to this one store and they had pipe cleaners and these fluffy balls. Both are on the list of what I need to get and they were like $20, it's like, okay. So I'm trying to order some stuff right now to my mother -in -law because she's coming soon. So I'm like, I feel really bad. I messaged her today. I was like, I've got like 20 books, I need you to bring in your suitcase, but I only got the paperback versions of everything, not the board books, which are extremely heavy. And then I managed to find about a third of the books on Kindle Unlimited, which I have a subscription to. So it's not going to be as tactile as having the actual book, but at least I have the book and we can put it on my iPad so it'll have color and stuff. Yeah, I'm nervous. I'm very like nervous about it because I'm nervous about his whole homeschooling journey. But I'm starting to, on Saturday, actually, we're meeting up with a group of other moms who also have three -year -olds who are doing homeschooling. So I think having more community will definitely help because there's a lot of online community. I have found so much online community. The homeschooling community has grown to something like five million children now are homeschooled because it exploded during COVID. And so there's so many resources, there's so much free resources like Khan Academy. And we just did, Khan Academy just had a summer camp, which I did with Luca, and it was really fun. They had Space Week and Science Week and Animals Week and stuff, and he really liked that stuff. So the community is huge and it's really growing. And I can understand why it's growing also, especially because there's lots of strange things happening in schools these days and not so safe things. So I think a lot of people are wanting to go that route more and more.

Melanie Avalon:
I wanted to be homeschooled so bad. Oh, really? Yeah, because I wanted to be acting. So I wanted to be homeschooling and doing community theater.

Vanessa Spina:
Get a private tutor kind of thing.

Melanie Avalon:
Yeah. Well, I just, I really wanted to do community theater and do day shows. Yep. Instead I was, I went to private school. I would do community theater, but then it's like in the evening. So, but, oh wow, that's exciting. So if you actually do him the whole, like the kids the whole way through, then it'll be, that'll be a lot of time, right?

Vanessa Spina:
Yeah, it'll grow. It's going to be easier now. I can do it in the mornings, but a lot of times my mornings are when I prep for podcasting and my interviews. So I'm a little nervous about how it's all going to work. But I think especially like the first year, you know, preschool is going to be okay. And then I think at some point I'll have to make a decision. Like, do I keep doing this? Do I scale back professionally or do we send him to school? And there's some wonderful schools here. You know, in Prague, there's some really wonderful schools, you know, that could be an option. But I think if we can, you know, we want to make it happen. So we'll see how it goes and how it works. And we definitely he has so much, he has so many like friend groups and play groups and stuff. So he gets a ton of social interaction. I think that's the main thing people worry about, you know, when you homeschool. He's not just like at home with us all the time. Like he has a lot of interaction with other kids, but it's going to be interesting to see how this year goes and see, you know, how if he's able to do it. So it'll be a good test for all of us. I would love to be able to do all of it, but we'll see.

Melanie Avalon:
Cool. Well, I applaud you. I cannot do any of that. So that's amazing.

Vanessa Spina:
Yeah, I mean, they're so special to us. And I know everyone's children, you know, are special to them, but we really want to spend as much time with them as we can as well. So homeschooling, I think, helps accomplish that. But whether or not it's feasible and manageable with both of us having professional careers as well, we'll see. Podcasting and the way that my work is definitely helps a lot with it. But that's really cute that you wanted to be homeschooled.

Melanie Avalon:
Yeah, yep, I really did. I think I like seriously considered it, like I think my parents considered it at one point.

Vanessa Spina:
When I was growing up, it was like, it was kind of like kids who were homeschooled were a little bit ostracized. Like I remember going to girl guides. I don't know if that's what we called it in Canada, like girl scouts. Girl guides? Oh, okay. And in my girl scouts/girl guides, there were some girls who were homeschooled and everyone was like, those are the girls who are homeschooled, you know? It's like, they probably were super cool. But you know, like people were weird about it when I was a kid. I think it's probably less a stigma now.

Melanie Avalon:
Yeah, I'm so disconnected from the schooling system now. I think that was the vibe, but I just wanted to do it and I knew I would have my community theater people.

Vanessa Spina:
Well, a lot of times you register, like usually the regulations are you register with a local school, you meet with them and we go over the curriculum and then they go in for testing. So that's a good way that you can like make sure that they're on track with, you know, what they're supposed to be learning.

Melanie Avalon:
Okay. Yeah. Yeah, I know. I know nothing. Yeah.

Vanessa Spina:
Yeah. And people are interested in it. It's really neat how many resources there are these days. Super cool. Yeah. What else is new in your life? Are you getting some fresh school supplies with these?

Melanie Avalon:
Literally, the only time, the only time I'm aware that school, I forget that school is like, I forget about like that age group of kids because they're like in school during the day. Yeah, I like don't see them. The only time I see them is when summer hits and I see them like around, I'm like, oh, that generation, I forgot about them. And then, but I see like school supply section and like Target and it makes me so happy and I want to go buy like folders. I actually did just order all these Lisa Frank folders. I love the Lisa Frank when I was little. I was like, I need some happy folders in my life. So I have this like sparkly unicorn Lisa Frank folder that I got on eBay for way too much money because it's probably like vented.

Vanessa Spina:
I just got like a unicorn colored one. It's like a shiny. I don't know what that color is

Melanie Avalon:
Oh my gosh, do we have the same one? Mine's shiny. Is it texture shiny? Is it textured? Does it have a deer in the background?

Vanessa Spina:
some frogs. I don't think they have Luca Frank here, but it's like that. I don't know what that color is, but you know what it kind of is like shiny like a unicorn or like a hologram, like silvery pink and purple. I don't know what that color is.

Melanie Avalon:
like iridescent. Yeah, iridescent. I sent you a picture of my Lisa Frank unicorn. There's like little rabbits and ducks and frogs.

Vanessa Spina:
an owl. That takes me right back to when I was little and I wanted all the Lisa Frank things. Lisa Frank.

Melanie Avalon:
was amazing. Yeah. I'm glad it's still around. You have to get on eBay and I think it literally said vintage folder. I don't know. These people were ahead of their times. They were like, someday these folders are gonna be worth something. Yeah. So I'm good. Just quick updates. I thought I was about to release my EMF blocking headphones and then I was... I have not gotten the rose gold ones to the place I want them to be at. So we're working on them still for manufacturing. So, but I'm wearing mine right now. And in the supplement world, I don't want to say it too early because I don't want to jinx it, but I'm hoping to launch digestive enzymes in the fall. So we shall see. I'll update more as I feel more secure about the timeline of that. Yeah, I'm really excited. So people can get all the updates for that at avalonx .us/email list. Oh, also friends, check out my new podcast, The Mind Blown Podcast with Scott Emmons. We are having the time of our lives talking about so many fun, different topics, things like the Dyatlov Pass incident and the Cecil Hotel in LA and the Mandela fact, and then random listicles like... things that vanish that you didn't realize are no longer around and it's just, we're having, it's, it's a really fun show. So it's called the mind blown podcast. So definitely check that out. Okay. Shall we jump into some fasting things? Yeah. Sounds great. So to start things off, I found another fun fasting review that we can discuss. This was called intermittent fasting. Does it affect sports performance? A systemic review. So this was a review published in nutrients in January of 2024. And it looked at studies from 2013 until today. I liked that they actually picked a start date. Like they didn't look at any studies ever because they were saying that around that time is when studies started coming out more about this, but it looked at 25 articles and the people in these studies, so that when you combine them all together, it was mostly athletes, but if not athletes, it was people who were physically active. Most of the studies, the people were practicing a 16 eight approach to fasting. So fasting 16 hours and then eating in an eight hour time window. A few of them were Ramadan, which ended up being 14 eight. So fasting for 14 hours and then eating in an eight hour window. And then one study wasn't quote overnight fast, which I, I actually have to look at the specifics of that because I'm not sure what that entails. What they found, they were looking in particular at how intermittent fasting, I mean, you can guess from the title, how it affects sport performance, their overall takeaway, which was super nice to hear it was that it's beneficial for body composition, does not reduce physical performance, does maintain lean body mass and does improve maximum power. And this actual different types of performance they were looking at were all over the board. So it was like cycling tests and sprint tests and treadmill tests. They also looked at stress tests on the different participants. Some were on interval training. Eight of the studies looked at muscle strength and endurance tests as well as peak power performance and average power. So going back again to what they were, what they found with the body composition. So they found in general that intermittent fasting did lead to a reduction in body weight and that that was beneficial for exercise performance. They said, I found this was interesting. So they said intermittent fasting could be considered an adequate nutritional strategy to reduce body fat percentage to an adequate number for athletes specifically. So that's between six to 12% body fat for men and 12 to 18% body fat for women. And then during that maintain lean muscle mass, which is just so, so important. They did note that, and we talked a little bit about this last week, but they did note that the inevitable calorie restriction that results from intermittent fasting is probably a key factor in these beneficial effects and exercise performance, even if it's not intentional. So basically people tend to non -voluntarily reduce their calorie restriction, even if they're not being told to in the study. So it tended to be around 10 to 20% per week, that people would just naturally reduce their, their calories, which as we've talked about a lot on this show is one of the amazing things about fasting that you can do calorie restriction without feeling like you're doing it and kind of just do it naturally, which is very, very cool. Other health things that they found were really important for exercise performance in general. So improved insulin sensitivity, reduced inflammation and strengthening of the immune system, which they were talking about was pretty important for preventing injury and also for recovery. So on the inflammation front, they found some of the studies showed that intermittent fasting activates a lot of mechanisms that enhance the immune system in general. So these are things like interleukin six going down in the fasting group and up in the normal group, which is an inflammatory cytokine. So it's nice to see that going down and especially with something like exercise, because we know that exercise is an inflammatory process for the body. So it's nice to have a, an anti -inflammatory response to that in general as well. Fasting had a beneficial effect on C -reactive protein, which can also indicate inflammation levels. And in particular, that was in a study and people who were fasting for Ramadan and it was football players. And there were actually two studies about that. And then this is interesting. So one of the probably key metabolic factors affected by fasting that could be having a really beneficial effect on performance is a specific hormone called adiponectin. So it's actually a hormone, it's affected by our circadian rhythm. So our, when we're asleep, when we're awake, and it's also affected by when, when we eat or not, and when we fast. And it is really important because low levels of it are associated with obesity, oxidative stress, and insulin resistance, which is not good. Higher levels are associated with insulin, insulin sensitivity, specifically in our fat tissue, which is awesome. So fasting seems to be a way to actually boost levels of adiponectin. So that might be having something with the, something might be going on there with the performance. And then something they did note was there weren't really intense negative side effects, except for some of the Ramadan studies, but they were positing that could be related to other things because Ramadan is a dry fast. So it could have been due to like electrolyte imbalance and other factors surrounding Ramadan in particular, not necessarily intermittent fasting per se. So what they ultimately concluded was they said that the heterogeneous samples make it difficult to have a definitive conclusion, but the data is favorable and could be recommended to follow intermittent fasting without reducing performance and athletes. So I really liked this review because, you know, we get so many questions about fasting and exercise performance and muscle and endurance. And it's, you know, nice to see that in general, intermittent fasting seems to pair very, very well with, with all types of exercise. So Vanessa, do you have thoughts?

Vanessa Spina:
I thought that was such an amazing summary of everything. I love the findings in it. You know, I love that it showed that it definitely did not have any deleterious effects on muscle mass and it helps with body re -composition and that that's definitely, you know, what drew, what was part of what drew me to it, you know, knowing that, and that you can safely do it without, you know, risking any of your muscle or your performance. It's really interesting too, because the International Society of Sports Nutrition recently came out with a position stand on ketogenic diets. I wonder if they did also an intermittent fasting, but they basically said that with ketogenic diets, it's basically neutral to negative. The key point is that it's neutral and not all of the research that they used had athletes who were fat adapted. So that's a big problem with studies on ketogenic athletes is they're not fat adapted or they'll, they'll do a crossover study. They'll get them to do it one way, be filled from carbs or fat, but it takes at least four to eight weeks to become fat adapted for your body to adapt and become really fuel efficient, you know, running on fat. But anyway, they basically officially stated that it was neutral and there's some other interesting researchers. So I think I think people are coming around to the idea that these strategies doesn't have to be necessarily negative. I think the main risk for athletes with ketogenic diets or intermittent fasting is under fueling. And I think that that does cause critiques. Because, you know, when you are an athlete, you need a lot of energy. And so if you are doing intermittent fasting, people tend to eat less, people tend to also eat less calories when they're doing keto. So I think that is something to pay attention to for athletes is to is to not under fuel because that could affect performance or it could affect someone's cycle. And that's usually where the critiques of it come in.

Melanie Avalon:
Wow, thank you for sharing that. The problem, like you were mentioning, I think, with a lot of these studies on keto is because of how long it takes people often to adapt. And so it's harder to draw definitive conclusions from a shorter term study, which the really intense randomized controlled trials tend to be on the shorter side. Yeah, it'd be nice if there are more study. And maybe there are, but it'd be nice if there are more studies where they study people already on ketogenic diets, so then they're like already fat adapted, and then start the study. That'd be really nice.

Vanessa Spina:
Yeah, so Dr. Philip Prince, he did one of those with Dr. Andrew Kootenick. I just interviewed Andrew last week and Dr. Philip Prince, my episode with him came out a few weeks ago and they also found that it was neutral. So that's the big finding is like, okay, so there could be some sports where you might get a slight advantage from being fat fueled because there are activities where if you are at 60 to 70% of your VO2 max, which is the maximum amount of oxygen that you can utilize during exercise. If you're fueled from fat, you could have a bit of an advantage here. That's what is sort of, I've always thought, and some people also think, but the main finding they had was that it's not a negative. So you can basically choose, if you're an athlete, to be fueled from carbs, to be fueled from fat, you are going to get similar results. And I think that it does two things. First of all, it challenges the negative viewpoint that people have on doing sport and not being super high carb, which is like a big critique that people who are always favoring carbs for athleticism, like you're going to have an advantage if you're carb fueled, et cetera. So not only do you not necessarily have an advantage from having carbs in your diet, but also being fat fueled is not going to negatively impact you. And I think just that says a lot. And I think that that's ultimately what I think we should all be sort of, the way that we should be looking at different dietary approaches when it comes to carbs, high carb, high fat, and this is something you and I talk about all the time, it's like choose your own adventure with your fuel, just prioritize protein and your outcome, whether it's fat loss or sports performance is probably going to be the same because they're just energy. They're just different forms of energy. You know, one may keep your insulin lower, as we talked about, but another approach might keep your insulin higher, but then you're not eating fat. So they have their different effects on the body, but physiologically, it's basically a wash, like whichever route you choose. And I think that's sort of a theme that we're seeing, whether it comes to fat loss or sports performance, you know, it's really the same and it's logical to me. I think you can achieve great results with different approaches. They have their advantages. Although the ISSN did say that although keto may be neutral, it is better for fat loss. That's interesting. They said it is better for fat loss. And I think that's sort of something that I've, you know, definitely known for a while. I do think it can be better for fat loss, but I think that is primarily because yet you do it's not so much about the fact that you get into a fat burning state because we can go back and forth on all the different mechanisms that are happening. I think it's just that people eat less when they're eating more protein and a little bit more fat, but it depends on the person, right? Because some people could also overeat that way potentially. When did that come out? Recently, yes. And I had the lead investigator on that who was Alex Leaf. I just had him on the podcast. That episode I think is coming out in a couple of weeks. By the time this is out, it'll probably be out. But my most interesting thing from that paper to me was that there's something called post -exercise ketosis. And I started testing this in myself and I did a workout. We did like a three hour hike last weekend and I had had a small breakfast, really small, but I had had breakfast, so I was not in the fasted state. And when we got home, I checked my ketones and I was in ketosis. And he was talking about this post -exercise ketosis because athletes use so much energy. A lot of athletes are in ketosis a lot more than they realize. It's also interesting.

Melanie Avalon:
Wow, I wish we could have a continuous ketone monitor like the way we have a continuous glucose monitor.

Vanessa Spina:
They're definitely coming and continuous insulin monitor would be amazing too.

Melanie Avalon:
Yeah, I know I'm continuous. I think like lactate might be coming as well. I'm right now I'm listening to the Peter T as episode. Are you about lactate?

Vanessa Spina:
Yeah, I've just been focusing on lactate a lot recently because I had Kristy Strohstruck. Her episode came out on my podcast yesterday and she's studying lactate right now. She's doing a big study on that. So yeah, it was interesting timing. And she was a mentee of Dr. Dom D 'Agostino. And I remember a few years ago, he kept bringing up lactate. And he was like, I think in the future, a lot of people are going to be looking at lactate, which is like, interesting that he knew that.

Melanie Avalon:
It was a long time ago when I first got interested in lactate and I had maybe not quite as predict the as Dom, but we're thinking like there's something here like this is interesting like it's that it's such a solid fuel for the mitochondria and we don't ever really talk about it much. Short term of course awesome well thank you for sharing all that I love that you interview all these researchers and can share all this information it's so helpful so fascinating.

Vanessa Spina:
for geeks like us. I love to geek out on this. I love that you appreciate it. But yeah, it's a great study and I'm glad we opened the episode with it. Awesome.

Melanie Avalon:
awesome. So, I do wonder with these studies in general with systemic reviews and meta -analyses, I wonder, like, could it have gone a different way? Like, could they have done the same title, intermittent fasting? Does it affect sports performance and systemic review? And just pick different filter criteria for the studies they picked and then pad different conclusions. I agree and I love the results, but I always, with all systemic reviews, everywhere, I wonder this. I'm like, how much do I act? Like, how do I even know, you know, what to trust and what not to trust? It'll be interesting to see the future of studies and how AI can help with that a little bit, like reanalyzing data and things like that.

Vanessa Spina:
Yeah, because Harvard just released a paper. They went back and reanalyzed the data showing that eating red meat increases mortality. Oh, what did it find? They found that it increases your lifespan by 6%. Oh, my gosh. See? Yeah, that just came out on the weekend. Oh, man. That's amazing.

Melanie Avalon:
Mm -hmm. It makes you wonder. It makes me wonder, yeah. Oh, what I really wonder about is, say, in another universe, what if all the studies were published that were done? Because, you know, so many are, like, not published because they, like, don't get the outcome they want or, for whatever reason, they have to stop it because of whatever, whatever. Like, if everything ever was published, I wonder what would look a little bit different. Definitely. Thanks to Ponder. Shall we answer some listener questions? Yes, I'd love to. All right. Would you like to read?

Vanessa Spina:
Britney's question. Yes. So our first question comes to us from Britney subject. Why am I not losing? Hi, I've been doing if for about two months now, I do an 18 six every day and I'm super strict about sticking to my 2pm to 8pm window. But I haven't lost any weight in three weeks. In fact, I'm up to pounds. I've also been super hungry in these last three weeks. Am I not eating the right foods? Do I need to be more strict about eating clean? I thought the beauty of IF was that in my window, I didn't have to be as strict on what I eat. Is this the problem? Would you please email me if you answer my question as I am new to the pod and playing catch up. Thanks, Brit.

Melanie Avalon:
Awesome, Brittany. Thank you for your question. So sorry that we did not email back, although I think when people email us, they get an auto response, but we're answering it now. So I feel like this is one of the questions about intermittent fasting. One of the foundational issues to address, which is basically, yes, the beauty of IF in general is that you can make these changes and often see weight loss, beneficial effects without changing what you're eating. That said, you might need to adjust what you're eating. And if you're asking the question, not always, but often, if you're asking the question, that probably is the answer. So you're being really, really strict about your time, your two to eight. So you're not really making any adjustments to what you're eating. And there can be a ton of magic if you change what you're eating. And it doesn't have to be crazy. You don't have to completely change your diet and be really intense and all of those things. But if you haven't made any adjustments at all to what you're eating, there's so much magic in just changing the types of foods that you're eating. And it doesn't have to even be restrictive. So rather than cutting out things, you could just have a paradigm shift where if you're eating processed foods, for example, maybe you just switched to eating whole foods only. So real foods in their real form. That can be magical. Or you could try a macro approach, like we've been talking about, like lower carb and or I guess not and lower carb or lower fat. But if you've been going three weeks and gaining weight, and I'm assuming we have to ask about body composition. So is this fat that you're gaining or is it possible that you're gaining muscle? That could be a possibility. Sounds like intuitively, that's probably not the case because I feel like you probably might be picking up on that. But that's the first question is what type of weight are you gaining? But I actually I am sort of haunted by this question a little bit because I've just been getting it for years and years and years, which is fasting is supposed to do all the magic by itself. So why do we have to change what we're eating? You can still eat enough in a small eating window to, you know, at the very least, make fasting, not give you the results that you're looking for. So I would just encourage a lot of mindset shifts here. Also the fact just to wait just to touch on it really quickly, you said that you're super hungry. So what basically what you're doing is probably not working. You said am I not eating the right foods? I would really, really look at the foods. So focusing on protein, like we talk about all the time, that might be a good place to start. So starting with protein could be a really, really great place to start. There will be a ton of magic for a lot of people if you make that the focus of your meal and then fill out beyond there. I would actually, I would probably start with that. Like try going on a whole foods form of protein approach and see what happens. And maybe because, you know, you're being so strict about your fasting window, maybe taking some of the stress around that and shifting some of the focus to the food choices. I just think there's a lot of potential here, but I'm really haunted by this question, Vanessa, because it does feel contradictory. You know, we often talk about fasting, doing all the magic by itself, but then also sometimes people need to adjust their food choices. What are your thoughts on that?

Vanessa Spina:
So I definitely agree. I think if what you're doing is leaving you hungry and not getting results, then I would definitely change up your macros and a good starting place. If you haven't done this already is using a tracking app and setting your grams of protein first. So you could do one gram of protein per pound of ideal body weight and just use that as a starting place and try to hit that every day and try to eat your protein first or at least every meal that you have in your eating window, especially the first one, try to hit at least like 35 to 40 grams of protein at your first meal. And it'll go a long way to making sure that you feel satisfied and not thinking about food. Protein is the game changer when it comes to feeling high levels of satiety, not feeling hungry, not thinking about food. I mean, it can also be other micronutrients, but protein really is the biggest macro because you have to get protein every day from exogenous sources, sources outside of your body, because we have nine essential amino acids your body cannot make on its own. So you have to get those from food sources every day. And most people tend to feel hungry until they get their protein needs met. So usually feeling hungry after you've had meals is because your body is trying to get more protein. So if it signals hunger, it knows if you eat something else, it might get some more protein. So that's just the, this is the concept of protein leverage and it's been proven in an incredible amount of research showing animals, humans, even insects will forage and look for food until we have our protein needs met. So if you get that out of the way, you prioritize protein. It goes a long way to helping with satiety. It also secretes a lot of satiety hormones like GLP one CCK it signals leptin, which helps you to feel fuller. And it also signals a few other satiety hormones that work on the brain. Some of them like GLP one are secreted in the gut and others have effects on the brain like leptin. So it is really powerful for hunger. I love the whole foods recommendation. Whole foods are higher in micronutrients, higher in fiber. Fiber is also something that makes you feel full for longer and it helps you also to, you know, maintain a caloric deficit so that you can get the fat loss that you're looking for while not feeling hungry all the time. So I would definitely try that out and see how it goes. I mean, that's definitely my, my top recommendation when it comes to achieving some body re -composition, some fat loss and also feeling satisfied ketones can also really help. So if you've ever considered keto, that's another option. Like we were just saying the ISSN just said it's the best diet for fat loss. So it's a great way to boost your metabolic flexibility, tap into your fat stores, become fat fueled. And that means that once you set your protein target, you can either temporarily do a lower protein amount, which is going to be probably closer to half a gram of protein per pound. And then having a restricted amount of carbs for a few weeks and filling in a little bit more of the calories from healthy fats that can really help get you going, especially if you know you've been stalled or kind of not, you said you gained a couple of pounds, so it hasn't really been going the way that you want. So the advantage with keto is ketones also are huge in terms of satiety. So you have the protein, which gives you the thermic effect of protein. You have the ketones, all of these things really help with satiety. And it sounds like that's something that you've been struggling with. So those are some different ideas you could try out for sure.

Melanie Avalon:
I love that. Thank you so much. And it's so interesting. I it blows my mind to think about, and I guess I used to be this way, people who haven't realized the importance of protein with satiety. Like I would be so hungry. If I didn't eat a high protein diet, I would be so hungry, like so hungry. And it's really magical, you know, when people realize just how satiating it is. Do you have esoteric thoughts on like this concept of, you know, we say fasting is all you have to do, but then people do need to change what they're eating.

Vanessa Spina:
I remember listening back to the podcast when you were hosting with Jin and I remember that being a big emphasis, especially from Jin, that you can just eat whatever you want and do this fasting throughout the day and you will lose weight. But fundamentally, the intermittent fasting is helping create a caloric deficit. You can either create a caloric deficit through doing exercise and burning more calories or through eating less calories. That's really the only way you create a caloric deficit is those two ways. By having an eating window and a fasting window, you're creating a caloric deficit, but it's much easier and a lot of research supports that the compliance is much higher when people do caloric restriction with this fasting window. I think part of that is probably some level of like ketosis people get into towards the end of the fast and those ketones help suppress appetite. A lot of people are not hungry in the morning too, so it makes sense to delay your first meal a little bit unless you wake up ravenous, which that's only happened to me a couple times in my life, like when I was during breastfeeding, like around pregnancy. Other times, I don't wake up ravenous. I usually am ravenous for coffee, but that's about it. I think the ketosis is probably what helps people get through the fasting period, but it's a much easier way of doing caloric restriction. Maybe it feels like magic because of the ketones, because ketones are magical molecules to me. They are something that humans are designed to produce in terms of how our physiology is because we've always historically went for periods of time without food and could very easily tap into our fat stores and create ketones for brain fuel, but your cognition also really improves when you're in ketosis, which is a nice side effect. I think why people feel so good and so energetic and their brains are really well -fueled when they're fasting throughout the day. I don't know. I think that's probably what I would attribute the magic to, but I never really was a big fan of the concept of just fasting all day and then just eating whatever you want and getting results because that to me is more akin to a crash diet. Some people may get results on that on the scale, but if you're truly assessing the quality of that fat loss, a lot of research shows that crash diets have upwards of 40% lean body mass being lost. You're stepping on the scale, seeing the number go down, but close to half of that is muscle or lean mass, so you're going to end up in a worse position after because you're going to have less lean body mass, which is that metabolically active tissue that helps you have a higher metabolic rate. I'm not in favor of those kinds of crash diets where people just restrict calories but just eat whatever they want and that not being whole foods, being more hyper palatable processed foods. The other reason I don't like that, not only does it affect body composition quite poorly, but it also makes people really hungry because I think most people don't know that hyper palatable processed foods are designed to leave you unsatisfied and craving more. They are not just designed to taste amazing, they're designed to make you feel like you need more, so you buy more of them. They're not designed to make you feel satisfied, protein is, and whole foods are, like with lots of fiber and lots of micronutrients, but processed foods are not, they're designed to leave you wanting. I think if people knew that, if more people really knew that those foods leave you unsatisfied and just starting to frame it that way in your head, like, what do I eat that makes me feel satisfied versus what do I eat that leaves me unsatisfied and then making your choices based on that, I think most people would want to feel satisfied and get on with their day rather than just having a momentary bliss that makes you wanting more at the end.

Melanie Avalon:
And I could not agree more. And related to that, we had an episode a few episodes ago with Dr. Naomi Parela at the Xero app. And it was interesting, something that you said reminded me of this, because we talked about GLP -1 inhibitors and like Ozimpic and semiglutide. She was talking about how when you're on those, for example, you like it completely kills people's appetite. So they're not eating, but it actually creates a high insulin state. So people are in this super severely calorie restricted state, but their insulin is high, so they can't really tap into fat. So then they're just losing muscle. And that's why people on those drugs, it's really, really important that they are on a high protein diet and creating muscle synthesis, signaling through protein, exercise, things like that. Because so many people on those drugs are losing a ton of weight, but it's a lot of muscle loss, not fat loss, which is really, really scary. And then they come out of it having lost muscle, not fat, and it's kind of like you're worse off than before. Something you said, remind me of that. I think you were talking about the type of fat that people lose or the type of weight people lose. The quality of the weight loss, yes.

Vanessa Spina:
the quality of the weight loss. That is the biggest problem. And unfortunately, those, a lot of the people who are taking osempic are the people who are not eating protein and doing resistance training. So they're not getting that muscle protein synthesis signaling because it's like a lot

Melanie Avalon:
of people who what they're, and I don't want to make blanket statements, but it is a lot of people who have not found the dietary approach that works for them. Like what they're doing is not working. So presumably they're probably not, they're probably not doing the things we talk about all the time on here because if they were doing that, that would probably be working. And I don't want to make blanket statements, but in general, you know, in general it's probably a lot of people who have not tried the things that actually would work. So then they just go on these drugs and then lose their appetite, don't eat the food. But then also, I thought that was so interesting though, because it's kind of like being in the facet state, except the opposite with like high insulin. So it's a really scary metabolic state to be in. We shall see. It's interesting though, because they do seem to have a lot of other potentially beneficial effects like helping people with addictions and things like that. And I'm really intrigued by the whole thing. Are they a big thing over there?

Vanessa Spina:
there in Prague? I don't know. Like, I mean, no one I know, no one that I know is digging them. I've had some friends here recently start carnivore. I've had some friends get into CGM's and not through me, this is just through other people that they follow, but no one that I know of. But I mean, in general, I don't know if it's a thing here. I think people in Europe are generally more metabolically fit, not in the UK. I've seen that. But in Europe, people are a lot more lean. And a lot of people walk everywhere. Like, it's quite, I would say, a lot of people are very, most people are very athletic, and it's rare to see someone in public that you would think, wow, that person is obese or morbidly obese. So I mean, it's not that they don't exist here, they're definitely are metabolic issues, because there's a lot of like bread and beer and definitely, you know, consumption of processed foods as well. But people in general, I think are so active, that, you know, there's just less like car driving and less convenience. So I think those, there's maybe a little bit less of those like Western comforts in terms of how people get around. And there's more of a traditional diet, like people eat more protein, they eat more organ meats. I don't know, we've talked about that before. Like every restaurant you go to here has organ meats on it, like, in terms of like a pate, a liver pate, or even just like soup with liver dumplings, like that's almost every restaurant. Yeah, it's really, really common. People eat more nose to tail, just culturally have less problems with obesity, but it could be coming, there's more and more fast food places all the time. But you think the movement part, you know, could be the reason, and a little bit more of the traditional diet adherence. So maybe in the future, but I would bet it's going to come to Asia if it hasn't already, because they're dealing with a lot more metabolic issues with their affluence, not Japan, but China, and other parts of Southeast Asia. Did you see?

Melanie Avalon:
See that TikTok influencer recently, I think she was Asian and she was eating and she died on the TikTok. Sorry, what? There was this TikTok influencer recently. I think she was Asian, but her thing that she was like an eater, like that's what her channel was. Like she just ate food. And so she died while eating. Oh, she over -eat. Yeah. A, it's really sad and B, it just, I don't know. It's really sad and it just speaks to, it's sad to me that like the food industry and like the concept of food has just become this obstacle and challenge and, you know, set up against us. Like we, like you were talking about, like this food is like created to make us want to keep eating it, which is crazy. And I've mentioned this before, but Mark Schatzger, who wrote The Dorito Effect and The End of Waving, I think I told you his theory about why people are overweight in the U .S. and not Europe. No. He compares like the dietary composition and he talks about how, you know, is it the gluten and the grains? No, they have gluten and grains. Is it the macros? No. You know, it's similar. Is it the fat content? No. Like what is the difference? Is it the calorie miles? Like what is it? He thinks it's the fortification of foods. He has a really, really interesting theory about this signaling from foods that are fortified with all these vitamins and how it just like freaks out and messes up our metabolisms. It's really, really interesting. It's like it's out there. Like I don't think anybody else is making this theory, but even if it's not the case, I think so much of it does go back to these processed foods. So and I was just thinking about you were talking about the liver meat and the there's such a difference in sorry, the liver and the organs. There's such a difference in eating, you know, nutrient rich foods where the nutrients are coming from the whole foods form. The fact that can have on satiety is just really incredible. So okay, any, any more thoughts?

Vanessa Spina:
I think that pretty much covers it for me.

Melanie Avalon:
me too. Now I want to go to Prague and like look at the restaurant menus and order something. Well, this has been absolutely wonderful. So a few things for listeners before we go. If you would like to submit your own questions for the show, you can directly email questions at ifpodcast.com or you can go to ifpodcast.com and you can submit questions there. The show notes will be at ifpodcast.com/episode390. Those show notes will have a full transcript as well as links to everything that we talked about. So definitely check that out. And we are currently taking submissions. If you would like to tell your own intermittent fasting story on the show and be interviewed by one of us, definitely submit to us. You can go to ifpodcast.com/submit, and there is a submission form there. And yeah, I think that's all the things. Anything from you, Vanessa.

Vanessa Spina:
before we go. I had such a great time answering these questions and talking about these topics with you and looking forward to the next one.

Melanie Avalon:
Likewise, thank you so much. Happy homeschool adventures. And I will talk to you next week. Okay, sounds great.

Vanessa Spina:
Talk to you then.

Melanie Avalon:
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by Podcast Doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Vanessa: ketogenicgirl.com

Original theme composed by Leland Cox and recomposed by Steve Saunders.

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts - it helps more than you know! 

 

 

Sep 29

Episode 389: Caloric Restriction Vs. Fasting, Triggering Protein Muscle Synthesis, HDAC Inhibition, Autophagy, mTor, Food Cravings, Avocados, And More!

Intermittent Fasting

Welcome to Episode 389 0f The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Vanessa Spina, author of Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight.

To submit your own questions, email questions@ifpodcast.com, or submit your questions here!! 

SHOW NOTES

Impact of Intermittent Fasting and/or Caloric Restriction on Aging-Related Outcomes in Adults: A Scoping Review of Randomized Controlled Trials

Listener Q&A: Rebeca - Avocados, avocados, avocados

Listener Q&A: Shari - If I want more muscle definition, should I eat shortly after my weight lifting session or complete my 16 hour fast?

Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.

TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.) 

Melanie Avalon:
Welcome to Episode 389 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of "What, When, Wine" and creator of the supplement line AvalonX. And I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of "Keto Essentials" and creator of the Tone Breath Ketone Analyzer and Tone Lux Red Light Therapy Panels. For more on us, check out ifpodcast.com, melanieavalon.com, and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Melanie Avalon:
Hi, everybody, and welcome. This is episode number 389 of the Intermittent Fasting Podcast. I'm Melanie Avalon, and I'm here with Vanessa Spina. Hi, everyone. How are you today, Vanessa? Doing great. How are you? I am good. I had the moment of all moments. You might have seen it on my Instagram, but I saw Adina Menzel live. Do you know her? I don't. She's the original. Do you know Wicked?

Vanessa Spina:
Oh, the musical. That was really popular.

Melanie Avalon:
She's the original alphabet and she's Elsa and let it end frozen. Oh, you must have loved that. She's saying, let it go, like live. And the whole audience was singing along and it was the most magical thing. My life is complete. I've been waiting two decades for this moment or a decade for that moment and two decades for the wicked moment. So that's amazing. Yeah. I'm like on cloud nine. And I also yesterday interviewed, very excited Dr. Naomi Parrella. She is the chief medical officer at the zero app, which have you ever used the zero app, the fasting app?

Vanessa Spina:
I have I remember using it when I was doing extended fasts I I used it a few times or more than a few times I used it regularly when I used to do inner extended fasting

Melanie Avalon:
Okay, how long ago was that?

Vanessa Spina:
Oh, before, I guess like before I had Luca, so like maybe 2018, 2019, 2020, I was doing a lot of extended fasting, but I, I really don't use it at all anymore because I'm not as much kind of stopped doing that.

Melanie Avalon:
Yeah, so that's also when I first used it was interesting. So I hadn't revisited it until prepping to interview her and it's changed a lot. Like it has a lot more features. It's really cool for like streaks and habit tracking and things like that with the calendar system and has a ton of resources. So like I opened it and on the homepage was a video with Peter Attia who apparently worked with them in the past. I was like, Oh my goodness. But it's super cool. I feel like I should be recommending it more, especially for people who are struggling in the beginning to stick to a fasting schedule or like get into, you know, really make it stick. It seems like a really, really great tool and resource for that, especially because we know, and I've talked about this on the show before, like dieting, for example, just the very act of monitoring what you're eating, like not even changing what you're eating, just monitoring what you're eating. It tends to create dietary change. Like there's something very powerful to tracking and accountability. So I think it'd be really helpful for people. And then she said she actually uses it in a, her own way as well, which is if she's wants to cut out a certain sort of food, like fast from like sugar or a certain treat, she'll use it that way. Um, which is really kind of smart, which I've actually, now I'm just thinking of all the ways I could use this app in the past. I've used an app where I was like, I'm not going to text this person. And it like, do you know how long you've gone? So maybe not for that reason. Well, yeah, you could, you could fast from people. Exactly. Yeah, but yeah, it's super cool. And listeners can get it. I guess I didn't even really see what it does. It tracks your fasting, but oh, and she said that the, the algorithm is very sophisticated and works with your personal data, like your, you know, your age and your sex, and then it integrates with your wearables and can take in data with the information that you tell it regarding your meals and such. And then from that, it generates when it thinks you're in certain fat burning modes based on the time and stuff like that. So I asked her about like, you know, the accuracy and she said there's, you know, a lot of, like they have a lot of science behind it. And so it was really, it was really cool. And we also, just as a side note, listeners, that episode will come out in a few episodes. And we went into a deep dive into ozimpic and semi-glutide. So I thought that was like really cool because her specialty is actually weight loss. That's like what she does. She is the medical director at Rush center for weight loss, actually. And so that's her specialty. So yeah, maybe we could actually talk about our updated thoughts on ozimpic and such, but in any case, before that, for listeners, you can go to ifpodcast.com/zero, and that will give you a free seven day trial to the plus version. And then it's always free regardless. So you can keep it for free or pay for the plus version. Yeah, it was super, super cool. So what is new in your life?

Vanessa Spina:
Just doing so much podcasting right now. I I have been recording four to five episodes a week I'm just really pumped by all the amazing people. I'm getting to talk to you and the podcast is just doing amazing and it's just like it's kind of a Lot right now doing so many interviews because it as you know for each one You know, you have to prepare quite a bit whether it's like reading the person's book or you know Reading at least a dozen studies or so that they've authored. So I feel like I'm constantly Shifting gears and I've got so many tabs on my computer open of different Different studies, but it's amazing. I mean I was just saying to Pete we had a date night because we had our eighth wedding anniversary On Saturday Oh anniversary. Thank you. We did a mini putt this amazing new place in the city That's kind of like Las Vegas, but it doesn't have all the casino the gambling It's just like a really fun place and we did mini putt, which is what we did on one of our first dates But we were talking at dinner and I was like, I just feel so blessed that I get to do what I love Every single day and I always dreamed when I was younger of being in a position where I would get to Read books and synthesize information and share it. I don't know why I've always wanted to do that and I find that's what exactly what i'm doing Every day and it's it's so rewarding and so fulfilling. I'm interviewing. Have you heard of timeline nutrition? No They are this incredible swiss company that has done Over a decade of research and they discovered this molecule. You've probably heard of urolithin a Yeah, they discovered it and it it generates mitophagy it generates autophagy, but mitophagy specifically the mitochondrial autophagy And i'm interviewing their chief medical officer. That's anurag sing the day after tomorrow. So i'm really deep in mitophagy Research and and just all the stuff that they've been doing. It's really amazing. I love whenever a company is research first, you know, they put all their time and energy into research and doing all the clinical trials and Coming up with things that can really improve people's lives and I felt the same way about Mimeo who you recently got to To interview is companies that are research first like that research forward and they're creating things That are related to fasting that benefit you Or that generate benefits similar to fasting You know, and I think there's a lot of interest in that at the moment just like there isn't, you know the zero app

Melanie Avalon:
I as well feel so, so grateful about the podcasting. I didn't have that as specific of an acute. Wait, how old were you when you decided you wanted to do that? Read books and I mean, it was.

Vanessa Spina:
definitely was always knew that I wanted to do something involving books. Like it was more like a writing a book, which as you know I ended up doing. But although I did enjoy that, I way more enjoy reading, synthesizing, and sharing. I don't know why, but it was, I think it was in my early 20s. Like when I was in university and I started to think about doing a career and I was like, I need to do something where I can read stuff and then synthesize the key points and share it. And I was like, I need to become a professional speaker. So I thought, I thought that's what I should do, you know, because there's people who do that. Like people like Brian Tracy and Tony Robbins, like these were my heroes. I was like, I need to do that. So I did do that initially right after I left school, but podcasting is like a way better form, way better method for it. But yeah, in my early 20s, I kind of realized that. And so yeah, the fact that it's, it's what I get to do every day is amazing. Even no matter how busy it gets, and I'm sure you can relate, it's always so satisfying because you know you're doing what you were meant to be doing or what you're skilled or talents or, you know, you're kind of utilizing all of your skills and talents in a way living up to your full potential. I guess that's how it feels like.

Melanie Avalon:
I couldn't agree more. I guess I always wanted to have a show, so kind of similar. And then growing up, in high school, I was always like, I don't know if this was YouTube, but I was always the study guide girl. I made the study guides. I feel like that kind of relates to this, taking in all the information and, like you're saying, synthesizing. I think my favorite thing is just getting to learn these completely different but interrelated topics and do a deep dive into them. It's literally almost every day. So it's just constant learning.

Vanessa Spina:
Yes. And I, I always love, I don't know if it's Sun Tzu said, if you do what you love, you'll never work a job in your life. Yeah. A day in your life, a day in your life. And I, I also discovered that quote when I was in university and I was like, you know, I would just want to end up doing something that I love. And I, this definitely never feels like work. Although there are times where I feel exhausted mentally, especially recently feeling a little tired mentally, but I never feel like I'm working. I feel like I'm doing what I love and podcasting. I always feel like I get into the flow with most guests with, I would say with over 90% of the guests, I feel like I get into a flow state with them and that's the best. Like, yeah, I'm not surprised you feel that way too.

Melanie Avalon:
Yeah, that's so true. Yeah, I literally had a moment, I think yesterday, I just sat in my car and I was like, I'm so grateful. I get to just learn all this stuff, like just constantly new things.

Vanessa Spina:
Yeah. And I think about you sometimes with, when I see the different episodes that you come out with, because your podcast is more broadly like on biohacking, it's less focused on one thing. So you really have a nice like wide variety of different topics that you talk about on the Melanie Avalon biohacking podcast. And I always think when I see a new episode come out, I'm like, oh, she must have loved doing that one. No, because I can imagine you like preparing for it and really enjoying that person's book or yeah, that's fun.

Melanie Avalon:
Yeah, it's really great. We we share that in common. I love that so much. Oh Man, okay. Well speaking of studies Yeah, speaking of studies So I was looking up to see if there were any you know Cool fun new studies out about intermittent fasting I found for this episode and next episode some New reviews I thought we could talk about so the study for today it's called Impact Of Intermittent Fasting And Or Caloric Restriction On Aging Related Outcomes And Adults A Scoping Review Of Randomized Controlled Trials. So this study looks at 30 articles and 12 of them were about intermittent fasting 10 were about calorie restriction and 8 were combined and what they were looking at in general was to look at the Cardiometabolic cancer and Neurocognitive outcome differences between both of those and adults questions they were looking to ask were they wanted to know basically what were the Like within the study the different effects of those different outcomes and adults They wanted to know what were the differences between those and these different interventions or effects on health and what was interesting about it was I Thought it was going to find more Specific like I thought was gonna say that intermittent fasting was better for this and CR was better for this but honestly the takeaway about everything was they were pretty similar so basically, they were equivalently effective for all three of those outcomes and really the only Main difference was because they were also in addition to that They're both associated with weight loss which seemed to play a role and in all those health outcomes But I have tended to report greater adherence compared to calorie restriction So the long story short takeaway was that both of these have these incredible outcomes for our heart for cancer and our brain and they are Likely in part active acting through weight loss for that but intermittent fasting just seems to be more Doable so people adhere to it better has more long-term sustainability If you like I can go into some of the like specific things They found I don't know if I should go that route or talk a little bit about IF versus CR Do you have thoughts Vanessa?

Vanessa Spina:
I mean, it's, it's, if there's anything specific you want to share, I found, you know, I wasn't surprised by the findings. This is something that I've, I always say is kind of funny to me because it's the whole reason why intermittent fasting exploded worldwide was because people found out that they could do caloric restriction without feeling like they were on a diet. That's really the whole thing. And then, and then people now critique it and say, well, it's the same as caloric restriction. Right. But that's the whole reason people got excited about it in the first place. And so the findings were not surprising to me because it is very, the results, the outcomes are equivalent between caloric restriction, intermittent fasting. I think that as the, so I'm interviewing a guest who actually specifically studied this in a couple of weeks. And it's really interesting. This topic, like comparing them. Yeah. He studied specifically, he got his PhD studying if there is a difference between intermittent fasting and caloric restriction. And it's yeah, it's really interesting because a lot of times like the studies don't equate the calories between the groups when that happens. But usually what happens spontaneously, people eat less when they're doing intermittent fasting, even then when they're doing caloric restriction. And it's like you said, the main takeaway from this review of the review, review of the men analysis is that it is more tolerable and people tend to stick with it more and are more successful with it. And there's something about just giving yourself this framework of being in a facet state, having a facet window for however long that is, that just works so well for people because you, you have this, it's like a psychological parameter around when you should be eating and when you shouldn't. And then you kind of go on autopilot after a while and you're just like, this is when I eat and this is when I don't eat. And when you have an open window all day, I don't know about other people are like this, but a lot of time there's that decision-making around like, should I eat now? Should I eat later? Should I have snack now? Or, and you almost sometimes feel hungrier just because you opened your eating window and you, you know, psychologically that you can eat. So it's such an effective tool for so many reasons. And like you said, a lot of the main cardio metabolic benefits, insulin sensitivity, improvement, et cetera, comes from the fat lost on either intermittent fasting or caloric restriction, intermittent fasting being a really effective form of caloric restriction.

Melanie Avalon:
It's funny. So yesterday when I was interviewing Dr. Perilla at the end, we were talking about if we could create any study, what would we create? And I said I would like to see more studies comparing intermittent fasting to calorie restriction and seeing what are the mechanisms there. So that's so cool. How did you find that guy?

Vanessa Spina:
I found him through Dr. Kurt Escobar, who's the PhD on autophagy that I recently interviewed. He's really interesting because he's a super sharp guy, but he's on this mission to correct a lot of the myths that are spread on the internet about autophagy and how it works. And he really thinks that a lot of people embellish or exaggerate some of the findings in studies because it gets, I don't know, he doesn't talk about this exactly, but I think it, he says it's usually because they want to sell you products or whatever. So they get your attention by embellishing or exaggerating what was found in a study and then they're able to get your attention so they can sell you products. That's his thing. And I understand where he's coming from. He's trying to set the record straight on what the truth about autophagy really is, like how much autophagy can you really get from different protocols? And I recently had him on the show and he interviewed this PhD who studied fasting and caloric restriction and compared it. And he believes that there is really no difference that looking at, I think he did a meta analysis looking at intermittent fasting compared with caloric restriction. And they found that ultimately if you equate calories exactly between the two, you're going to get the same results in terms of fat loss. If there's a caloric deficit, which there would be from caloric restriction, improvements in insulin sensitivity usually come from that and all the other associated benefits also come from that. But Dr. Sachin Panda, he did a lot of research comparing the two and he definitely found in his research that there were additional benefits from intermittent fasting. And one of the things that I tend to think about is ketones, right? If you get into ketosis, you're getting the signaling benefits of ketones. So I asked Dr. Kurt Escobar, is there a difference in autophagy between someone who fasts, for example, doing a 16, eight fasting period and an eight hour eating window with someone who does eats the same amount of calories in that 24 hour period? Is the autophagy the same? And he said, you might have a slightly higher increase towards the end of the fasting window, like right before you break your fast. And that's also where you would start to see that elevation in ketones, et cetera. But he said, in terms of autophagy, if you take both, it's a washout. They both will end up giving you the same amount of autophagy. But I do think that there is some benefits to the elevation of ketones. And he also talked about the timing. If you're measuring things in a study, when are you doing the measuring? Are you doing it during the fasting window? If you're doing it right before someone breaks their fast, there's probably going to be elevation in certain markers and autophagy proteins that you wouldn't see at other times of the day.

Melanie Avalon:
curious about, did he say anything about the difference in muscle preservation? Like a bolus of protein after a fasted state compared to small amounts of protein?

Vanessa Spina:
No, we didn't talk about that. We were talking more about exercise and fasting and caloric restriction. And he was saying basically that the autophagy is generated when you have an energetic crisis at the cellular level. And that usually happens through exercise, but it doesn't have to be fasted exercise. It just happens from exercise because exercise is when you create that intense demand for ATP. And that creates an energetic crisis for the cell. Whereas fasting, and this is something I've been talking about with a lot of scientists recently, fasting was believed to be doing that via this AMPK, PGC1 alpha axis, because they found that in mice. But then they recently found that that pathway doesn't exist in humans, which I think I was telling you about last week. So it doesn't mean that it's not there. It's just that exact pathway is not there as it is in rodents. So some things are there. As you know, some things you'll find in rodents just are not applicable to humans. But yeah, we didn't specifically talk about protein. And I think if I would have asked him that, he would have said he wasn't an expert in that area.

Melanie Avalon:
Yeah, because that's something I'm super curious about. I'm really, really curious about this question. I'm a bit haunted by it. In this review, the things they found that were similar between IF and CR, so they found that they better maintain blood glucose levels and lipid metabolism, so that's dealing with fats in the body, that they induce neurotrophic and autophagy responses, that they increase the production of metabolites like ketones and BDNF, that they may promote reductions in oxidative stress and inflammation. So those were the main things they were talking about as being similar. What was interesting about the review was they would look at different markers sometimes to draw similar conclusions. So for example, with managing cardiovascular risk factors, they were saying that IF showed positive effects on blood lipids and glucose metabolism, and then specifically CR reduced LDL cholesterol and the total cholesterol HDL ratio. So what's interesting to me is it's different. They're not looking at the exact same thing when they're making the comparison. They did both show reductions in oxidative stress and inflammation, as well as lower levels of CRP for both. Yeah, I just really want to know if it's, I don't know why I want to know so bad, but I really want to know. It kind of reminds me of, weren't we talking about something recently where, or now am I thinking of a podcast I was listening to? I'm having a memory of talking about something where we thought it was the same pathway, but it was actually different pathways. Was that me and you, or was that me listening to a podcast?

Vanessa Spina:
I mean, we were just saying that that AMPK PGC1 alpha axis was generated from fasting in mice, but it doesn't generate in humans. So in mice, fasting will generate mitochondrial biogenesis, but it doesn't in humans. The exercise does, but not the fasting. So that's why I've recently been playing around with doing a pre-workout meal. And I've been doing this now for two weeks and I've lost almost five pounds. Oh, wow. Yeah. So what I'm trying to figure out now is, is it the small meal is giving me more energy for my workout or is it the additional triggering of muscle protein synthesis from that other meal, which it could be, but it's really interesting because I didn't expect that I didn't expect that to happen at all.

Melanie Avalon:
How does that normally, because I know nothing about the general timeline of weight gain and weight loss with having a child. So like, is that the normal trajectory? I know it's all different and unique for individual people.

Vanessa Spina:
I mean, I'm already like at my goal because I didn't gain weight with my second pregnancy. I actually lost a little bit of weight when I was pregnant. Oh, wow. Yeah. I didn't gain weight. Like you lost weight, like my body fat, like when I was pregnant. Oh, interesting. Okay. Yeah. Like at one point, I had really had to start eating more. It was just at one point in the pregnancy, baby was obviously like extremely healthy the whole time, but I didn't put on any additional weight during this pregnancy. So when I, after the baby, I didn't, like I'm not in like a postpartum like fat loss or weight loss journey or anything. It's just more what I'm always doing, which is optimizing my body composition, like wanting to be gaining muscle. And if I can lose, like I wanted to lose like between three to five pounds, like just overall, like not related to postpartum or anything, just in general, like the same as before I had the babies. And so I was pretty close to my goal, but yeah, it was really surprising because things could be different hormonally right now. Like the hormonal landscape could be different for me. I'm like about eight months out since having the baby, but yeah, it's, it's not really related to the, to postpartum weight gain or anything like that.

Melanie Avalon:
Wow. Gotcha. No, that's super cool. I love the, um, the self experimentation. How do you, how do you monitor your changes in your body composition?

Vanessa Spina:
So I use a scale at home and then I go for pretty regular DEXA body scans. I have a place near me, so I'm going to go for one pretty soon. But it was so interesting because you always think that adding more meals is not going to make you lose fat. That seems so contradictory. But now that I understand how muscle protein synthesis works and how much ATP and energy it requires, it does kind of make sense to me. And I have had people message me this in the past that it happened to them. And I thought, oh, they must be unicorns or something. Because usually, in a way, you would think this defies thermodynamics. But it doesn't because protein is so thermogenic and you burn about 30% of the calories, somewhere between 20% to 30% of the calories that you ingest because of triggering muscle protein synthesis. I think that it could either be that that meal, like I said, is giving me more energy to work out harder, which is what I was thinking at first. But it could also be that it's just generating a higher thermic effect from building muscle, from triggering muscle protein synthesis. But yeah, really, really interesting.

Melanie Avalon:
Yeah, when I first started doing my really crazy diet experimentations back in the day, and I've talked about this a lot before, but I basically went through a period of time where I was eating just, like, just lean protein. And it's because intuitively I was like, I feel like I can just eat this unlimited and probably the more I eat, the more weight I'm going to lose. And that's very not scientific, what I just said, but that was my experience. Because I just was looking at, you know, what you were talking about with, like, how thermogenic protein is and how it really does, you know, go into the pathway of often becoming muscle. And then the pathway to fat conversion is just, you know, much more longer and complicated. So basically, keep adding the protein, the lean protein, you think it can be really magical for people. Just, like, in the body composition world and muscle building. Whatever I'm thinking of with the different pathways is, I think it's from some podcast and it probably has nothing to do with what we're talking about. But if it comes to me, I will mention it.

Vanessa Spina:
Thanks for sending me that study, it was interesting. It was kind of like...

Melanie Avalon:
Not a let down, but I was excited. I was like, oh, it's going to be like, show some differences. But instead, it was kind of like they do the same thing.

Vanessa Spina:
Yeah, we could look at Dr. Sachin Panda's research on a future episode because he definitely, you know, really believes that there's a lot of additional benefits from time-restricted eating than, you know, versus caloric restriction. And he, you know, believes he's done the research to prove that.

Melanie Avalon:
Yeah, no, I would love to because yes, I want to know the differences.

Vanessa Spina:
I mean, the last closing point on this, I would say on this study, is to me, it's an amazing way to do caloric restriction. And I do firmly believe you get some additional benefits. I do believe autophagy and fat loss could be similar, but I think you get additional benefits from ketosis because you start generating ketosis, most people, if they skip breakfast and you start getting into that state of ketogenesis around like seven, eight, nine in the morning if you've been fasting since dinner the night before. So if you delay breakfast, you're definitely getting some ketones on board and they have amazing signaling properties, I think, that are understated because they have epigenetic signaling qualities they have signaling on the HDAC inhibition, histone deacetylase inhibition, which is something that drug companies are spending billions to try and replicate. You can get that naturally from ketosis. So I think there are longevity benefits from the increase in ketones, especially towards the end of the fast, that are not being accounted for enough.

Melanie Avalon:
Yeah. I mean, that's what that's what would make sense to me. It just seems like you would create a different metabolic signature, eating the same amount, like same amount of calories, but eating them throughout the day versus this fasted fed state differentiation. You just see, I don't know, just, it seems like there would be something different, but yeah.

Vanessa Spina:
We can do Dr. Panda's studies next time.

Melanie Avalon:
Yeah, that'd be great. Should we answer some listener questions? Yes, I would love to. All right, would you like to read the question from Rebecca?

Vanessa Spina:
Yes. So our first question today is from Rebecca and the subject is avocados, avocados, avocados. Hi, ladies. I love the podcast. Thank you for all that you do. I recently started working from home and I realized that I don't get a lot of steps in a day. So I now take a walk every morning to get a coffee and listen to your podcast every day. I'm slowly catching up on all the podcasts that I missed. I'm also doing a slow transition back to IF. I was doing awesome with 18 to 20 hour fasting leading up to my wedding and then a series of life events hit, new job, new city, new house, family member fell ill with cancer, on and on and on. And while I fell off the wagon, I am slowly climbing back on and getting at least 16 to 18 hour fasts in with a 20 to 23 hour one in here and there. No changes yet, boo. But I am committed for a few months. All this to ask my question. I tend to open my window with an avocado with sea salt. It is so good. And now I absolutely crave it. I wake up thinking about it and there are days I would probably eat three to five avocados a day if I could. My question is why Google tells me that it could be a deficiency in essential fatty acids, low iron, or the whole what you eat you crave based on your gut bacteria. Well, I don't think avocados are bad and having one a day isn't super stressful to me. I do think that the urgency with which I crave them is causing me to pause and wonder what is going on. Other things I crave are coffee. Admittedly, I have a pretty bad caffeine addiction that I am just not interested in changing once in a while chocolate mainly because I am trying to mostly follow paleo and allow myself some dark chocolate once in a while carbs and salt. Thanks for any tips that you might have. Awesome.

Melanie Avalon:
First of all, avocados, do you like avocados, Vanessa?

Vanessa Spina:
I love them and they are full of potassium, which I just had to say because it's the first thing that came to my mind.

Melanie Avalon:
Oh my goodness. I remember avocados were one of those foods that did not taste like what I thought it was going to taste like. Like I didn't have one for the longest time and then I have one for the first time and it was like, oh, it's like, when is this?

Vanessa Spina:
magical. It is magical. It's funny because it reminded me when I was in university, I used to also have an avocado every day and it was the first thing I ate every day. And I would actually, this is really funny, but I would slice it in half and put it in a container overnight with an open lemon that I would also slice in half. And in the morning, it would make the avocado taste lemony. And it was amazing. Also with a bit of salt on it, there was something about it that was just insanely delicious. It would get infused with the lemon and I would have that every single day. And I remember my mom, she would be like, aren't you worried about cholesterol?

Melanie Avalon:
Oh man. I used to put the lemon on it too. I used to do, okay, I used to do lemon pepper and lemon on the avocado. Oh my goodness. There was something about, I remember my friend Jason was like, you have to try lemon pepper on avocado. It's going to change your life. And it did. There's something about the lemon. Oh man. You should try the lemon pepper. Like try it, try it and report back. It's going to change your life. It's going to change your life.

Vanessa Spina:
change your life? Yeah, avocados are magical.

Melanie Avalon:
I just remember though it not tasting like what I thought it was going to taste like. I think because I associate it with guacamole, which I never had, and guacamole you kind of associate with Mexican food, so I thought it was going to be like Mexican food tasting. I don't know. It was not what I thought at all.

Vanessa Spina:
texture.

Melanie Avalon:
Oh man, I'm craving an avocado. So, well, first of all, I'm really sorry Rebecca about, although this is kind of an old question. So hopefully things are doing well with your family member and all of the things. And like, this is a really old question. So I really am curious where she's at now with her job and her life and where she's living and, and everything. So sending love there as far as, okay, my first initial thought, interesting that your thought was about potassium. Mine was that this is a habit craving thing, because we know, we know our brains release dopamine based on habits. So you can actually, it's really interesting. You can create dopamine releases from things that don't even really mean anything to you, but the brain likes patterns, especially if you think that these patterns are keeping it alive. So it's quite possible that, and this is just me like, just hypothesizing. It could be a lot of different things and I don't know the answer, but it could be that there were some or are some nutrients and avocados that you did really need. And since you started opening your fast with it, it was a high reward situation where you're looking forward to it. You're opening your fast with it. You're getting all these nutrients. So it's like good, good, good. It's signaling good things to your brain. And then if you repeated that and you're like opening the window with it every time, you're going to probably quickly start really looking forward to that. And I mean, I think that could happen with almost, I mean, a lot of foods. I mean, I even do it because I open my window a very specific way and I definitely, I don't say not necessarily that I crave it, but I really, that's like what I need to open my window. And I would feel very weird not doing that, which is like my cucumbers and my wine. And we do know, so she mentioned the whole eat what you crave thing with the gut based on your gut bacteria. We do know that's a thing. So basically what you eat influences your gut bacteria and then your gut bacteria crave that thing you're eating. And that can be a reason that can be actually pretty hard to get off of like the processed food train, for example, because you start cultivating these not so good gut bacteria that are craving that not so good food. And on the flip side though, when you change your diet, you can actually start slowly craving the foods you're eating, which is very, very cool. So the reason I'm thinking it's more habitual now is that if you've been doing this, I don't know how long she said this has been happening, but if it's been a substantial amount of time and you're still intensely craving the avocados, I think you probably would have received the nutrients that you were deficient in by now. I mean, I guess it's possible not. To me, it sounds more like a habit driven thing, especially because you also know you admit that you crave and have quote addictions with other things like coffee. It doesn't sound like you actually have like a habit or an addiction around chocolate, but you do talk about craving different things. Yeah, I will put my money on it being a habit thing. What are your thoughts, Vanessa?

Vanessa Spina:
That was the first thing I thought of as well is, you know, it being a habit, sorry, the first thing I thought it was actually potassium because avocados are really high in potassium. And I'm always really interested, you know, by things like cravings, like dark chocolate. Could it be that you're low in magnesium? Like if you're craving bananas or potatoes or avocados, which are all high in potassium, could it be that you're low in potassium? You know, it's interesting to consider. I'm not saying that that's what's happening, but it's just what came to my mind because those foods are high in it. So sometimes cravings can be associated with that. I would think that it's probably just because it's so amazing because as we were talking about avocados are magical and delicious. The only thing that I would say is, and we probably won't have the same opinion on this, but if you are waking up already thinking about your meal way later in the day, that to me doesn't sound like a fun day. So, you know, and I found that like I have done intermittent fasting for so many years. And like I would say, most of the time that I was doing it, I was enjoying it because I didn't have any thoughts of food during that time. And that's what I enjoyed about it was the freedom from thinking about food or meals. And then I would usually think about food around the time, you know, that it was opening my eating window. I'm sure that's not the case for everyone, but to me that feels more, I wouldn't say white-knuckling it because it's not like you're saying in your question that all day long you're like tormented by the thought of this avocado, but it does sound like you're thinking about it quite a lot. So, you know, I don't know if maybe your eating window is too long. As we were just talking about, there's quite a bit of research showing that intermittent fasting and caloric restriction can produce the same results. So what if you had the avocado a little bit earlier in the day, and then you wouldn't be thinking about it all day. It's just something that I would maybe try experimenting with. I've tried with so many, I've experimented with so many different kinds of fasting approaches. You know, I've done, the most recent one I was doing was circadian rhythm fasting. So I was having a breakfast every day and then having dinner, and I would fast between breakfast and dinner. And I really liked that. That could be something you could try. There's having breakfast and lunch and then fasting until breakfast the next day. I tried that one, probably the one I struggled with the most, so not one that I would recommend. But that's because, not because I was hungry at dinner, but because I wanted to partake in the social activities, like with friends or with family of having that meal, which dinner usually is a more social meal. So I would just play around with your fasting window. If you're really, really wanting to do intermittent fasting, you know, I doubt it's related to a deficiency because you're eating it every day. So if you're having it every day, then you're probably not deficient in that thing. I think it's probably more maybe around the fact that you're just waking up and you're hungry and you want to have something. So you know, there's lots of different ways to approach whatever it is that your goal is. If it sounds like you would like to potentially lose some body fat and improve your body composition, you can still achieve that by having the avocado or having your first meal earlier in the day. You know, it doesn't have to be, you don't have to do an 18 or 20 hour fasting window to achieve your goal. Some people do that because they find themselves free from thinking about food all day. But if you are thinking about food all day, then I would think that would defeat the purpose.

Melanie Avalon:
I also have a wild card suggestion, this total wild card. This might just be something to try out of curiosity and experimentation, but I remember when I was going down the fasting mimicking diet rabbit hole way back in the day and contemplating doing it. That's Dr. Valter Longo's basically approach to creating the metabolites and effects of intermittent fasting, but you do it for like five days. There's the DIY version where people kind of just create a meal that, oh, wait a minute. No, because his is low. Wait, his is... Oh man. Now I'm trying to remember. I just remember there was a DIY version online where people were eating avocados, but now I'm wondering if that matches up with the macros of his diet because his diet tends to be low fat. So I'd have to revisit that. Basically, well, FMD or not. I know there's a community out there where they do this avocado fast thing. You could just try that out of curiosity. She said, I could eat three to five avocados a day if I could. You could try an experiment where you eat like five avocados for a few days. Just out of curiosity, I'm not prescribing this as like a diet to follow long term, but if you are into self experimentation, I think it could be interesting. It'd be really... It'd probably get you really deep into ketosis. I don't know what you think about that crazy idea, Vanessa.

Vanessa Spina:
Yeah, I mean, this is not a nutritional advice podcast because we are not qualified to do that. So definitely not any kind of, you know, recommendation, but it does, it does sound like something fun to do being as avocados are so delicious. And like you said, you could have three, three to five a day. You probably could have three to five a day and still get to your goal. So I totally get where you're coming from on that.

Melanie Avalon:
It reminds me of the fat fasting that people would do. It would be a way to get an extended amount of time. This is going to sound counterintuitive to everything that we've talked about, but the Dr. Valter Longo FMD thing, a lot of the benefits that he finds comes from the really low protein intake. So it could be interesting. Maybe we could do it for like a day. Maybe we could have like an avocado day and see what happens. I know Dave Asprey.

Vanessa Spina:
An avocado day would probably be fun. If you are looking for body re-composition, yes, I agree, you'd probably get into ketosis because your protein would be so low. But avocados actually have a lot of carb, so avocados are mostly carb and fat. So I wonder, probably even with five, you probably would be low enough, but I'd have to look it up to see. But you probably would be low enough just on calories, although it depends on the size of the avocados because I think some of them are like 300 calories each.

Melanie Avalon:
Now I'm craving avocados.

Vanessa Spina:
Now you wanna do an avocado date. I wanna do an avocado fast day, yeah. You should do an avocado date and report back.

Melanie Avalon:
sounds really miserable to me. I can't do the like day. I can't do like the eating throughout the day. For your OMAD.

Vanessa Spina:
to see the avocados, avocados for, you know, for, for a fun experiment, you'd probably be in ketosis, although I'm gonna see how many carbs are in an avocado.

Melanie Avalon:
I think it's only like three or four. I don't think it's that much. 13.

Vanessa Spina:
Is some of that fiber? Yeah, 10 grams of fiber, but I never did like the net carbs thing. So if you're doing net, then it's probably three. If you don't do net, it's 13. So you probably could have two and being ketosis or three maybe, but that's really not your question. I know. But yeah, for body composition, ultimately you, you want to have some protein in there, I would think. So, you know, I, I think the reason avocados are so attractive, just like nuts is that, you know, they have lots of amazing nutrients in them. They have lots of energy, lots of carb and fat, and they taste so, so delicious. And that that's what makes them so magical, but they only have three grams of protein. So if you had five of them, you'd be getting like 15 grams of protein, which like you said would probably put you in ketosis, but it won't help with long-term body re-composition and gaining more lean mass.

Melanie Avalon:
I know Dave Asprey has his low protein days as well, so it'd be like a therapeutic approach type thing.

Vanessa Spina:
Yes. I've totally been changing my thinking lately on, on protein restriction. Oh yeah. And mTOR and everything, which is like a much larger conversation, but it was really interesting because I know it's a topic that we both love. And, you know, how do you balance all of that mTOR activity with AMPK? And it really, it really is interesting because Dr. Kurt Escobar was talking about how the mTOR that people talk about in a negative light is actually dysregulated mTOR. And that's something you don't want to have a lot of, but the mTOR that you get from eating protein and doing resistance training, you never want to really avoid that. And you can get autophagy from mTOR, which is so counter to what I used to think, because once in autophagy, once the lysosome fills with enough amino acids, it actually triggers autophagy. And the metabolic autophagy that you trigger from exercise triggers that housekeeping, that cellular housekeeping autophagy. So I used to always think for autophagy, you needed AMPK, you needed fasting, you needed to avoid mTOR with protein, et cetera. But you actually get autophagy from mTOR. Like the whole system is so much more complex than we often make it seem like AMPK fasting autophagy versus mTOR protein muscle building. And you can actually get a lot of autophagy from mTOR, which the whole point of that being you don't have to do protein restriction to get autophagy and to kind of balance things out. So I've been changing my thinking on that lately, but I know it's something that a topic that we're both interested in.

Melanie Avalon:
Yeah i remember when i was talking with my friend james climent who wrote a book called the switch he does a lot of studying on blood work of longevity and. He's talking about how long in tour stays on and that's what that's when i realized that i know nothing about him to her.

Vanessa Spina:
and the different mTOR complexes, mTOR1 and mTOR2.

Melanie Avalon:
He was talking about how, and I don't want to get this wrong, but basically like, and I don't know what the exact experiment he was doing or what he was testing, but he was talking about a situation where protein or whatever or something was stimulating mTOR and it was still on like, you know, 30 hours later or something. And I was like, okay, nevermind, I don't know anything, like, I don't know what's happening here. Did you listen to that interview? Peter Attia interviewed a woman and like her thing was mTOR.

Vanessa Spina:
don't know. I'd love to get their name and go look it up. It was a really deep dive. I'll have to find it. You know what's blowing my mind lately is the podcast transcripts on iTunes. Oh, I listen on Spotify. I don't know if Spotify has this, but iTunes now has transcripts for every podcast. And so you can search the transcripts on the app. So if I want, like, if I want to go back and find that interview, I can search in the transcript just when they talk about mTOR. For us too? Yeah. And you can search specific terms, but you can also watch the words as you're listening, which is a new thing that I love to do because it's like subtitles. So it kind of helps me to deepen my understanding when it's something really complex. I can listen to it and I can also watch the words as it goes through the transcript.

Melanie Avalon:
I had a moment, sorry, just speaking of this week, because like one of my best friends ever, shout out to Carmen and me, he's directing his first feature film with a really incredible cast. And I was watching his producer cut, so there's no subtitles, obviously. And I was like, whoa, this is like a whole new experience. I forgot what it was like to watch something without subtitles. I think it made me watch it a little bit better. I used to think it was the opposite, the subtitles were helping me, but now I'm wondering if I'm becoming reliant on subtitles, well, like for videos, like for movies and TV, because you watch with subtitles, right? I love them.

Vanessa Spina:
but also I have two kids that are constantly making noises, so I can't really watch anything without subtitles now.

Melanie Avalon:
Yeah. So that was a moment. I was like, I don't know what to do with myself. I have to like, listen. Oh my goodness. Love it. Awesome. Well, this was super fun. So if Rebecca is still around, definitely let us know how it went with the avocados, which I am now craving.

Vanessa Spina:
I was going to say if we want to do this last question, it's kind of related, like we could answer it pretty quick because it's kind of related to what we've just been talking about.

Melanie Avalon:
This is from Sherry. She says, if I want more muscle definition, should I eat shortly after my weightlifting session or complete my 16-hour fast? Should I break my fast and take collagen and creatine right after my session and then eat a meal after I have fasted 16 hours? I am 59 years young and could stand to lose a little fat on my arms and belly around three to five pounds.

Vanessa Spina:
That was some alliteration. Should I eat shortly after my weightlifting session? It's very poetic writing. So, I would say that, in my opinion, it probably just comes down to what feels best for you, and we might have different opinions on this. Being as what we were just talking about with the studies and the meta-analysis talking about chloric restriction and intermittent fasting, basically generating the same amount of fat loss between the two, I think it really just comes down to how you feel best. If you like to eat right after your weightlifting session, you can do that. If you want to break your fast and have collagen and creatine, and also have a meal right after your workout, then you can definitely do it. I don't think you need to get to a certain goal, especially with the hours, and if you want to lose some body fat, like three to five pounds you were saying, ultimately if you were doing chloric restriction and you were doing any kind of intermittent fasting, according to the definitions we were recently covering, at least 14 hours of fasting, you're doing intermittent fasting. So, I would say just however it works best for you. I like playing around with different things. I recently started doing a meal before my workouts, and I've been losing, it was about three pounds now, almost five pounds in the past couple of weeks. So, I think it's worth experimenting and finding whatever you feel best doing, because I did my workouts fasted for so many years because I thought I was getting more mitochondrial biogenesis from that. When it turns out, it's really just the exercise that's doing that. Personally, I've been finding it fun to play around with that and to experiment. Ultimately, I've been having better workouts, having a small meal, not a huge meal, just a small meal before working out. I'm still doing intermittent fasting, according to those definitions, and I'm getting better results, which for me, I'm trying to focus on what the outcome is. It sounds like you are also interested in three to five pounds of fat loss. So, it made me think of my personal experience, but I think it really will just come down to what kind of caloric deficit you're creating, whether you're doing a 16-hour fast or longer or shorter. As long as the calories are equated, you're going to get the same amount of fat loss, whether you eat right after or if you fast longer during the day. That's my take on it. What about you, Melanie?

Melanie Avalon:
Before that, what do you think about the collagen and creatine specifically for taking those?

Vanessa Spina:
in terms of the fat loss.

Melanie Avalon:
Yeah, she should break her fast with collagen and creatine right after her session and then eat a meal.

Vanessa Spina:
I mean, I think those are probably great for boosting. I mean creatine has been proven in the science to help boost lean body mass. And there's lots of meta-analysis showing that it increases fat loss in women. So it definitely can help, including that in your routine. Having it right after a session, I don't think it matters when you take it. If you have it right after your session, in terms of the timing, I don't think it matters. And the same with collagen. As long as you have it sometime during your eating window. But I can't really speak to the specifics with regards to fasting for 16 hours or not.

Melanie Avalon:
And I think we've talked about it a lot on this show about there's this idea that you have to have the protein right after the exercise and that's not necessarily the case. And I really think it's about what works best for you. I would have a little bit of a different approach if I was a professional bodybuilder or that's my job and then it would be a little bit more specific. But for the everyday person just wanting to exercise, maintain and gain muscle, follow the healthy diet that works for them, I really would do the window that feels the best for both the exercise and the hunger overall and all the things. So I eat regardless of whatever activity I do during the day, I always eat way later at night. And that's worked even with doing M-sculpt where I go in and do these sessions earlier in the day where it's creating really intense muscle proteins, synthesis, signaling in my muscles and I don't eat until later that night. Well, this was absolutely wonderful. A few things for listeners before we go. You can submit your own questions to the show at questions at ifpodcast.com. If you would like to come on the show as a featured guest, we are going to start having some guest interviews. So for that, go to ifpodcast.com/submit and then you can fill out a form there to submit to share your story on the show. These show notes will be at ifpodcast.com/episode 389, they'll have a full transcript as well as links to everything that we talked about. So definitely check that out. And then you can follow us on Instagram, we are @ifpodcast, I am Melanie Avalon, Vanessa is @KetogenicGirl. And I think that's all the things. Anything from you, Vanessa, before we go?

Vanessa Spina:
I had so much fun and really enjoyed the questions and the study that we talked about, so looking forward to our next one.

Melanie Avalon:
Me too. I will talk to you next week. Okay, talk to you then. Bye. Bye.

Melanie Avalon:
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by Podcast Doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Vanessa: ketogenicgirl.com

Original theme composed by Leland Cox and recomposed by Steve Saunders.

If you enjoyed this episode, please consider leaving us a review in Apple Podcasts - it helps more than you know! 

 

 

Sep 22

Episode 388: Special Guest: Dr. Naomi Parrella, Weight Loss, Fat Loss, Semaglutide And GLP-1 Inhibitors, Fasting With An App, Muscle Loss, High Protein Diets, And More!

Intermittent Fasting

Welcome to Episode 388 of The Intermittent Fasting Podcast, hosted by Melanie Avalon, author of What When Wine Diet: Lose Weight And Feel Great With Paleo-Style Meals, Intermittent Fasting, And Wine and Vanessa Spina, author of Keto Essentials: 150 Ketogenic Recipes to Revitalize, Heal, and Shed Weight.

Today's episode of The Intermittent Fasting Podcast is brought to you by:

LMNT: For fasting or low-carb diets electrolytes are key for relieving hunger, cramps, headaches, tiredness, and dizziness. With no sugar, artificial ingredients, coloring, and only 2 grams of carbs per packet, try LMNT for complete and total hydration. Be sure to try the new LMNT Sparkling — a bold, 16-ounce can of sparkling electrolyte water. Go to drinklmnt.com/ifpodcast to get a free sample pack with any purchase!

To submit your own questions, email questions@ifpodcast.com, or submit your questions here!! 

SHOW NOTES

LMNT: Go to drinklmnt.com/ifpodcast to get a free sample pack with any purchase! Learn all about electrolytes in Episode 237 - our interview with Robb Rolf!

Naomi's background

Exercise doesn't drive weight loss

Hormonal fluctuations affecting fat loss

Fasting for women

Semaglutide and GLP-1 inhibitors

Developing the Zero App

Data collection and sharing with other wearables

Diet mindset and tracking a fast

Fasting studies

Caloric reduction

Our content does not constitute an attempt to practice medicine and does not establish a doctor-patient relationship. Please consult a qualified healthcare provider for medical advice and answers to personal health questions.

TRANSCRIPT

(Note: This is generated by AI with 98% accuracy. However, any errors may cause unintended changes in meaning.) 

Melanie Avalon:
Welcome to Episode 388 of The Intermittent Fasting Podcast. If you want to burn fat, gain energy, and enhance your health by changing when you eat, not what you eat with no calorie counting, then this show is for you. I'm Melanie Avalon, biohacker, author of "What, When, Wine" and creator of the supplement line AvalonX. And I'm here with my co-host, Vanessa Spina, sports nutrition specialist, author of "Keto Essentials" and creator of the Tone Breath Ketone Analyzer and Tone Lux Red Light Therapy Panels. For more on us, check out ifpodcast.com, melanieavalon.com, and ketogenicgirl.com. Please remember, the thoughts and opinions on this show do not constitute medical advice or treatment. To be featured on the show, email us your questions to questions@ifpodcast.com. We would love to hear from you. So pour yourself a mug of black coffee, a cup of tea, or even a glass of wine, if it's that time, and get ready for The Intermittent Fasting Podcast.

Melanie Avalon:
Hi, friends. Welcome to episode 388 of the Intermittent Fasting Podcast. I'm Melanie Avalon, and I am here today with a very special guest that I am very excited about. So the backstory on today's conversation a while ago now, quite a while ago now, I tried an app called Zero, which I'm sure a lot of you guys are probably familiar with because it actually helps you track your fasting. So something really near and dear to the heart of this community. So I tried it a while ago. I haven't used it recently, but I did sort of recently, a few months ago, got reached out to by the app, because they wanted to have their chief medical officer come on the show and share more about the app and everything that she's doing in her work with health and weight loss and all the things. And so I was obviously over the moon thrilled at this idea, because I know the app is so valuable for people in their fasting journey. I knew it would be of such an interest to everybody. And then I was talking with Dr. Parela before this, but I dive deep into some of the other work that she's doing in her in her past working with, you know, thousands and thousands of patients. And she is really a wealth of knowledge when it comes to finding the diet that works for you weight loss resistance, really making metabolic changes for people in an often confusing and disempowering world, especially when it comes to just knowing what to do and doctor patient relationships and all the things and has worked on a pretty cool study about Ozempic. And I know we get a lot of questions about that as well. So there is so much that we can talk about here. I am so, so excited about about this opportunity. And I will say before we even jump in France, because we're going to talk all about the app, but if you go to ifpodcast.com/zero, you can get a free seven day trial of that app. So definitely go to that link. But in any case, I'm here with Dr. Naomi Parela. Dr. Parela, thank you so much for being here.

Dr. Naomi Parrella:
Melanie, thank you so much for having me. I'm super excited, especially with your audience.

Melanie Avalon:
So a little bit about you, so you are the medical director at Rush Center for weight loss. And you've done a ton with speaking and for people like United Airlines and Google and all the different things. And now, like we were talking about, you work at zero as well. So questions for you. Your personal story, like what led you to what you're doing today? Did you always want to be a doctor? When did the interest in weight loss in particular come into your life? What happened there?

Dr. Naomi Parrella:
Yeah, great question. Hard to answer. So I am not somebody who knew I wanted to be a doctor very young. As a matter of fact, I was pretty sure I didn't want to do that. You know, I was born in Japan and grew up in Japan, moved to the US when I was in high school and had this experience of different kinds of health experiences and perspectives across different cultures. So already, you know, that was just kind of interesting. And then, you know, did undergrad and, you know, started a family after graduating. And during the time that I was taking care of my little guy, I really became super interested in the medical profession, just what they were doing, what they were advising, because I had so many doctor's appointments for a newborn baby for all the prenatal care. So I started just, you know, being around much more with the medical providers and became very curious about the different recommendations they made and how things were very different hearing, you know, how people were talking to each other in the health care that I was receiving. So long story short, I got excited about all the different things related to lifestyle. And this was actually even before because as an undergrad, I had been an aerobics instructor and a personal trainer and was very interested in building communities around health. And so I was doing that actually after I had my babies. And along the way, I decided I would see if I could get into med school. So I took some classes, I studied while my kids were sleeping, went to med school and became a doctor. So it was kind of a roundabout sort of way that this occurred. And my practice has also evolved organically as well. So that's how I kind of got to this current space.

Melanie Avalon:
Oh, first of all, that is an extremely inspiring starting becoming a doctor after having kids and all the things. So it is never too late and no excuses for not, for not doing what you want to do. That's amazing. And so with your work as a doctor, so you said that you, you know, were initially having all of these appointments for your child and becoming intrigued with that. Where did the switch or the focus on weight loss in particular come in?

Dr. Naomi Parrella:
Yeah, that's a great question. So actually, while I was at the University of Wisconsin-Madison, I, like I said, I was a personal trainer and aerobics instructor, and I noticed that in the rural communities outside of the city, there were no gyms. And in those days, people were using VHS exercise videos. And I thought, wow, you know, I wonder if I could bring exercise out to the farms and see if I could build a community and get buy-in for it because people would be a thing to do together instead of in your own living room, you know, watching a video and doing exercise. I thought, I want to go out into the community and see if I can build interest and build a community around that. So that's what I did. And it was actually quite fun. I started with two students, and we were in elementary school gymnasium. So you can imagine how awkward that is when you're the instructor and you don't know which one to look at, right? Because you don't want to, like, look too intensely at one and not the other. And so they were so fantastic. And sure enough, word of mouth, right? Communities develop and they talk to each other and friends share really good information. And so while I was teaching, I would be, you know, sharing what I was learning in school on campus. Slowly, my classes grew. And so they grew so fast and so large that we had to move into a high school gymnasium, which was pretty awesome. So I saw that just by having fun exercising together, you could actually bring a community together and inspire others to get active as well. So along that way, people started asking me a lot of questions and I was not involved in medicine. I had no idea what a normal blood pressure was. They started asking me all sorts of questions in the class. So I started hanging out in the medical school bookstore when we had bookstores before on campus and reading a lot about the different, you know, questions they were asking me about. So just learning on my own. And this was, you know, obviously before having kids. Then once I had kids and started play groups and started health conversations for our children, you know, a bunch of parents getting together, then parents started asking me about losing weight after having been pregnant because they had gained a lot of weight during pregnancy. And so I started really studying and working on that and we created groups and worked on weight loss with small children, not for the children, but for the parents. You know, from there, like I said, I went off to med school and during medical school, we didn't talk about nutrition at all. We didn't talk about weight back at that time either. Not very much. Once I went into residency and I started making recommendations to individuals about their weight and seeing that disease processes were reversing. Patients were having great outcomes. I started getting referrals from specialists who would say, I don't know what she's doing, but if you need a primary, go see Dr. Perala. She'll take care of it. And so slowly I just turned into the weight loss doctor over time and it's, you know, been great fun. And this is pretty much what I was meant to be doing, I guess.

Melanie Avalon:
with the start with the focus on exercise. So what were you finding that was working? Was it, was there a common theme that worked for everybody or was it pretty unique to people when it comes to exercise versus counting calories versus changing macros? Like was there a magic formula?

Dr. Naomi Parrella:
Well, so what's interesting is when I first started, so as an undergrad, I, you know, obviously having lived in Japan and then moving to the US and seeing sort of the different shapes and lifestyles, I really thought I would teach people to exercise. And so it was really exercise more to help people achieve their weight goals. And what ended up happening was I had like a 0% success rate in helping people lose weight by teaching them how to exercise. They had a great time, they got physically fit, they were more active, they engaged in their world more, but long-term weight loss success was pretty much a big fat zero. And so, you know, I realized I have to do something different here. And that's when through, you know, the postpartum period and, you know, after having children, I really started diving into the diet and paying attention to different things about diet. So first, I really did believe calories in, calories out. I did believe that was the driver and that I needed to make sure, you know, people were eating less calories. And the strangest thing happened, people would come in and they would say, I'm eating less calories, but I'm not losing any weight. So of course I'm asking all my other trainers and other people I know, and they say, oh, they're probably just lying. They're probably really eating more than they say they're eating. So of course, you know, you start kind of questioning yourself because everybody was being unsuccessful. And here I am giving this supposed amazing advice. So I had to really go back to the books and it wasn't until I became a physician and had enough patients that I started realizing what my advice was, was completely wrong. It is not calories in, calories out. Calories are not the answer. So, and exercise clearly wasn't the answer. And what I found was by changing how people signal their body and the hormone response to that, then I could achieve amazing results that everybody told me was not possible. And that was the first moment I started seeing, my patients showed me, you can reverse type two diabetes. You can reverse the need for blood pressure medicines. That blew my mind because of course in med school I had not been taught that in residency. I never saw that. And so my patients showed me through their quote, miraculous recoveries that I had it all wrong early on. And so I started seeing, it really is about what you put in your body, how you take care of your body, what you do with your body, causes a change in the hormone responses, hormone signal to the body, what to do with fuel, whether you have access to certain fuel. And that is the secret to weight loss.

Melanie Avalon:
So I think about the calories in calories out piece quite a lot. And subtle nuance question about it, because you're saying that you know, it's not calories in calories out. Is it that it's not calories in calories out? Or is it that the way we perceive calories and calories out is not what actually ends up being the calories and calories out? What I mean by that is, you know, we think that we can just count the calories that we are taking in and that we can somehow magically also count the calories that we're expending. When maybe there's like a lot of other factors that are affecting, you know, how calories are actually burned or not. I guess the question is, in the end, is it still calories in calories out? It's just that we, you know, set up a metabolic system that led to more calories going out than they otherwise would have because of the metabolic setup.

Dr. Naomi Parrella:
Melanie, that's a genius question and insight. And I just love that you asked this because I think it is one of the most misunderstood. So the calories in, calories out, you're right. If we were a robot or a machine in a vacuum where the environment doesn't change, then yes, you can calculate what goes in and you know exactly what the burn rate is and then that is a calories in, calories out approach and that follows laws of physics. But we're not in a vacuum, our environment changes and the body changes and adapts. So you're right, metabolic rate can change from day to day. So just because right now my metabolic rate might be a certain amount, tomorrow it could be different and it could be dependent on multiple factors and the environment and what I'm putting in my body. Did I get enough sleep? How are my hormones? What time of the month is it, right? All of those things. So you're right. So ultimately, calories in, calories out sort of works but you can't use that to calculate what's appropriate for you and you're right. The kind of calories also matter. So if you have a bag of some candy or cookies and or you have a potato and or you have a piece of meat, fish, chicken or you have a salad, those are all gonna impact the body very, very differently. And the hormone response to those different foods and macronutrients will result in whether you're burning fats, whether you up-regulate your metabolism, whether you are storing fat. And so you're right, it's way more complex than I'm just gonna count the calories I'm eating and I'm gonna watch what I'm burning, using my various biosensors or getting my metabolic rate tested. So it's way more complex than that because the body keeps adapting and different calorie inputs have different metabolic responses, meaning the hormones are different.

Melanie Avalon:
Okay, I'm so glad you got what I was asking. I was like, okay, yeah, I love this so much. It's so important, because I think people so often, they just want to make it simple. It's not simple at all.

Dr. Naomi Parrella:
There is a way to make it more simple, to think about it a little bit more simply. So we know all living beings have to have fuel and energy, right, the fuel to burn so that you can do things and stay alive. And so if you have infinite sources of fuel, your metabolism runs nicely, you're good to go, you can heal, you can play, you can do all the things. But if you don't have enough fuel, your body is gonna slow down its metabolism and it's going to shut things off and it's not gonna repair as well. And it's going to have to pick and choose and prioritize where it's gonna put its energy and where it's gonna use the energy. And so this is one of the biggest challenges with when people do a calorie restriction approach. If you force your body to have less calories, then it needs to do its daily functions, then it's gonna do less. If you, on the other hand, change the hormone balance so that you can burn fat, which we all have enough fat on the body to basically keep us going for months on end, if we can tap into the fat burning, then whatever you don't, for example, eat or take in as calories, you burn off your body. So that's a point where you might not be that hungry because your body's getting enough fuel. And so then you would end up eating less, which means you have less calories coming in, but not because you're forcing your body to try to function with less calories. It's because your body has access to the stored calories on your body, the fat cells.

Melanie Avalon:
And I think that's one of the biggest, you know, paradigm shifts I had historically, and this was forever ago because I've been doing intermittent fasting for so long, which by the way, do you do intermittent fasting daily or.

Dr. Naomi Parrella:
Absolutely. I'm post-menopausal. If I don't do intermittent fasting, I can't fit into my pants, for sure.

Melanie Avalon:
or how do you approach it?

Dr. Naomi Parrella:
Yeah, so I approach it, I had to change it up because I have different kinds of days. And so one of the things I've learned over the years is the body adapts and you want it to be able to adapt. So there was a period of time when I was very strict and I was doing 16-8s. And after a while, it wasn't as effective for me. It wasn't that it wasn't effective, it just didn't have a noticeable change. I sort of, I don't want to say stalled, but sort of stayed the same. And I was really interested in optimizing further. So I realized if I change things up and respond to the season, my sleep, my stress, if I pay attention to more factors than just the clock, it makes a big difference. And so this is why I like actually tracking, because then I can see the patterns and I can start connecting the dots and actually ask my patients to keep track as well so that we can see what's that pattern you need like right after the holidays or after a celebration. What do you need when you haven't been eating and you now need to replenish because you were sick and you didn't feel like eating, right? So I change it up.

Melanie Avalon:
Do you find, because this is probably one of the main questions we get all the time, is fasting good for women? Is it detrimental for them? Is it too stressful? Is it going to affect their fertility or their cycle? What do you find working with women in particular in fasting?

Dr. Naomi Parrella:
Yeah. So fasting is really, really individual dependent. So I hate those kind of answers where you're like, well, that doesn't really tell me what to do. But the bottom line is if you have metabolic dysfunction, even just early on, so that means your waistline is increasing or larger than it was before and you're not pregnant. If you have abnormal blood work, like your triglycerides are high or your A1c, which measures your blood sugars over the past three months, things like that. If there's markers that are elevated, that would also be blood pressure, if that's high, then you would want to use fasting to help with those conditions. And it would be something that even a 12-hour fast would make a difference. If somebody has PCOS, polycystic ovarian syndrome, then they might need to do a little bit longer fast, depending on the type of cycle. For women, if you're in your follicular stage, which is right after your period until the time of ovulation, you have a different fasting profile than premenstrual, right before your period when you're ravenous and having cravings. So it kind of depends. It's not awful. I hate that answer.

Melanie Avalon:
No, I mean, it's basically the answer, though. So I guess what we can do with that answer is how, how intuitive is that for women? So can they just go based on how they feel? Or do they need to be taking metrics, you know, tracking things? How can they, how can they find what works for them?

Dr. Naomi Parrella:
Yeah, I think actually you can be a little bit intuitive, but there are some rules that I recommend just because if you're very dysregulated, for example, you have an irregular sleep cycle or work schedule or you're studying weird hours, whatever, I think it's helpful to just know, number one, regardless of what you're doing or what stage of life you're in, you probably will benefit from making sure you have 12 hours out of 24 hours that you do not eat. And you can drink water, you can have black coffee, you can have unsweet tea, but pretty much if you do that at a bare minimum, that should be okay pretty much at all times unless you have a problem with maintaining weight, that would be the only time. So in other words, if your weight is very, very low and you're trying to increase your weight. So I think that's something that's very straightforward. Intuitive from there is if you had certain reasons that you wanted to extend your fast, like I said, different medical conditions or chronic disease, and you wanted to extend your fast, then you may want to extend it slowly. So for example, somebody says, I'm going to do 14 hours or I'm going to do 16 hours. If they're sitting there at the 15th hour, staring at their watch being like, oh my gosh, if I don't eat for another hour, I hit the 16 hour mark, but oh my gosh, I'm starving. Their body's cortisol stress hormone level is sky high, right? And if you're watching the clock like that, it's no longer effective. So yes, you can choose to extend the fast, but just pay attention. It might have to go a little bit slower if your body is screaming at you to eat. The other thing would be if you are feeling super hungry, you want to reflect back, are you getting enough water, salts, and proteins? Those would be the things that drive hunger. And it's really, really important to pay attention to that because if you're not getting enough of those, your hormones will get screwed up. You will lose muscle mass, right? Those are things that aren't very beneficial. So I think there's a little bit of a nuance. And again, paying attention. If you start getting hungry before you want to end your fast, take notes, pay attention. Were you getting the nutrients you need? Are you maybe under more stress than you expected? Did you not get enough sleep? Your body signals to you and it's important to pay attention. And then if you're like, oh no, I'm just wanting a cookie, then that's really not true hunger, right? If you couldn't satisfy it with a chicken or egg or something.

Melanie Avalon:
We talk about protein all the time on this podcast. We are major, major protein fans. And actually, and that's another question we get is women seem to often struggle to get enough protein in their eating window. So I eat a short, like a four hour eating window every night. And I don't have, I'm a bad person to ask about how to eat protein because I, um, I eat so much and it's like so natural to me that I forget people struggle to, I'm like, how do you struggle to fit it in? And I eat like pounds in my like four hours. Do you find that that's a common theme where women struggle to get enough protein in their window or how do you handle that?

Dr. Naomi Parrella:
Yeah. I mean, Melanie, kudos to you that you are talking about protein and that you're saying you can do this in a four hour window because a lot of people don't believe that's possible, right? And in the past, we used to... Oh, it's possible. Oh, totally. Totally. And in the past, we used to tell people, oh, you can only absorb 30 to 40 grams at a time, blah, blah, blah. Totally not true. And recent research has demonstrated, actually, your body can absorb what you put in if your body needs it and it's bioavailable. So I do hear a lot of people struggling with getting adequate protein because it's something that's not in a vending machine. It's hard to get really quickly. You have to kind of plan for it. So this is where it starts getting difficult. Also, individuals who don't like to cook or who don't have someone to cook for in their house, for example, if you don't have children that you're cooking for, then it also becomes easy to not, quote, prep or prepare proteins. And then if you go out, it can be challenging because your plate's going to be piled high with cards, you're going to have bread baskets brought to the table, right? It's not necessarily like they're bringing meatballs as the...

Melanie Avalon:
When I, this is a true statement. When I go out, I order for dessert a savory dessert. So I'll order like another appetizer or another steak. You have to tell the kitchen though, ahead of time.

Dr. Naomi Parrella:
That is so funny.

Melanie Avalon:
So I tell them like early in the entree, I'm like, I might order another entree for dessert. So and I do.

Dr. Naomi Parrella:
I love it. Oh my gosh. I've never even thought of doing that. That's so genius because they only bring you the dessert menu, right? At the end, they never bring back the menu with the appetizers on it. It's brilliant.

Melanie Avalon:
You know it's so fun the first time i did it i felt really like awkward and weird but then once i realize that you can do that it's like the world is your oyster like there's so much potential.

Dr. Naomi Parrella:
Totally. Oh my gosh, Melanie, I'm totally feeling that. That's brilliant. Love it.

Melanie Avalon:
And I even asked the waiter one time, I was like, do people do this? And he's like, yeah, sometimes people order savory desserts. So that's where I got that phrase from. So then I was like, okay, this is a thing. This is a thing.

Dr. Naomi Parrella:
That would be a really cool cookbook. I have like a million cookbooks and that would be a really good one.

Melanie Avalon:
Oh, it would be. Yes, I love it. I love it so much so many ideas. So thank you for focusing on protein as well. And I actually this is actually a really quick rabbit hole tangent question. But as I have heard you talk a lot about is it semi-glutide is how you say it. I thought that's how you say it. But then I was listening to your interview and

Dr. Naomi Parrella:
I say semaglutide, but some people call it semaglutide, so either one is this. Yeah, fine. I'll know what you're talking about.

Melanie Avalon:
I'm super curious that the studies that show, you know, these negative changes in body composition with the weight loss, so loss of muscle mass and such, do you think if the participants were actually eating a high protein diet that they would preserve muscle or do you think it's something else going on?

Dr. Naomi Parrella:
Oh my gosh, I love this question. Melanie, this is too fun. Well, okay, so let's talk about this because so many people misunderstand. So the GLP-1 receptor agonists and the GLP-1 GIP, which, so those would be semaglutide and terzepatide, brand names Ozempic, Wigovi is semaglutide, and then Manjaro and Zepbond are terzepatide. Those medications work in two places, right? They work in the brain and in the gut. And in the brain, it tells the brain you're satisfied, you don't really need to eat, and you're basically the drive is gone. So people love that because they're like, the food noise is gone, I'm not having cravings. And interestingly, it's also seeming to be helpful for addiction. So it just kind of kills that drive. And then it works on the gut by just slowing the movement of food through the gut, and also causing an insulin surge if you eat foods that have that digest down into glucose. All right, so this is important because what happens when you spike that insulin when you have an insulin surge is you turn off fat burning, you turn off access to your fat cells, right? So that's a massive energy source that you shut off access to. Okay, so now you don't want to eat, and your blood sugars look great because the insulin took care of whatever it was that you ate. And so basically, what happens is if you start running out of fuel, instead of burning the fat on your body, because the insulin is so high, it actually forces your body to start melting down a little bit of the muscle, right? So that's a very, very not helpful thing because it's so hard to keep our muscle and build muscle. Now fasting also causes people to not eat, right? Insulin is low, exactly. And so it has a fabulous effect turns on autophagy, which is the body recycling cells, it maintains the lean tissue because when insulin is low, you burn fat for fuel. So this is like a complete game changer, right? Yes, people are losing weight. And you are right, if they eat enough protein, that will stimulate muscle synthesis. And so you might be able to maintain more the muscle. And that's what we do in our clinics. So any of my patients that choose to be on one of these medications, we first make sure they're getting adequate protein before we prescribe these medications, because we want to make sure they get in the habit of doing that before they no longer care if they're eating enough, right? So you're right, we have been monitoring body comps, and they seem to be better maintained if the individual when they do eat, they prioritize protein. If they start with a piece of bread, it's over because they get full so fast, they don't eat their protein. Now they don't have enough protein to maintain their muscles, and they've probably spiked their insulin. And there we go.

Melanie Avalon:
Wow, okay. Do you find that if they pair exercise with it that that helps maintain the muscle?

Dr. Naomi Parrella:
Yeah, it does, but they still need to eat enough protein, right? If your body turns over between 2 and 400 grams of protein a day and you're eating like 30 grams of protein, hello. You know, that's a problem.

Melanie Avalon:
Are you concerned about long-term effects that we might not be aware of?

Dr. Naomi Parrella:
Absolutely. Yeah. So there's so many, that's like a whole other topic. But the most important thing I think is if people are not prioritizing protein, not staying active, not drinking enough fluids, eating late at night, it's going to create problems. Absolutely. There's going to be, and that's long term. So you can lose weight in multiple different ways and some is good and some is bad. If you lose weight, like with cancer, you're losing muscle mass, right? That's terrible. And so same thing with these medications. If you do it right and you get appropriate counseling so that you know that you're getting adequate protein, you're doing all the things so that you can maintain your muscle and you can lose fat mass, then these medications can be very helpful. But if you don't have anybody teaching you how to do that or making sure you're doing that okay, it can create a huge problem. So we monitor multiple things, but a person can even look in the mirror. And if you look in the mirror and you look at your face and you notice that around your temples, you know, the parts right at your temples on the sides of your eyes, if that starts indenting dramatically, that's not what's supposed to happen, right? That's a loss of the wrong kind of tissues. So that's what we define as cockexia, losing more than 5% of body weight and really losing it in an unhealthy way.

Melanie Avalon:
have this study where you talk about the effects of these drugs and the effects they might have on people with plastic surgery and just the actual surgical procedure and such. But it was saying in the study that some of the, like the stomachs of those patients on these drugs, they could have food in their stomach after 18 hours of fasting. This is a really random question and I don't know if you know the answer, but I was just thinking about that and I was like, so does that mean that if you're 18 hours, you're 18 hours fasted, but there's food in your stomach. So is your body not going to like, will that food be signaling something to your body to not make adaptations into the actual fasted state?

Dr. Naomi Parrella:
You know, that's a really good question. And I don't know that that's been studied. That's a super brilliant question, Melanie. I don't know the answer to that. What I do know is because the food moves through so slowly and in different people, it's different, right? So some people, their stomach stops moving entirely and that's what all the problems with these meds are about, or some of the problems. But yeah, it's a huge problem because it could be signaling continuously, right? And we don't really know what exactly is happening with regards to the signaling there. And if, I mean, it might be published. I haven't seen it.

Melanie Avalon:
Yeah, so fascinating. And speaking of signaling, just a comment on something you were talking about earlier with the absorption of protein in a small window. We recently talked on this show about a study that came out pretty recently, and it was looking at the post absorption window of protein and muscle protein synthesis. And I have to find it, but basically the takeaway was that they only had really looked up until a certain point and just assumed that it wasn't really absorbing. So that was really nice to hear.

Dr. Naomi Parrella:
Yeah, and this is one of the things, Melanie, you've probably already figured this out too. Many of us have started recognizing or appreciating the human body is designed to thrive. It's not designed to always be the same. It's designed to adapt and thrive. So if your body needs something, we know, for example, iron is very hard to absorb. And if you have enough iron in the body, and you don't have a condition that causes excessive iron absorption, you won't absorb as much iron. But at times when your body needs iron, it will do better with the absorption of iron than at times when it doesn't need as much. So, you know, again, with the protein, if you need the protein, it's very unlikely that your body is going to ignore it as it goes by, right, just because it's hit a certain threshold that we have decided is the threshold or the time, right. So, yeah.

Melanie Avalon:
It reminds me of, have you heard of, I think it's called hepcidin, which is basically like the insulin equivalent for iron, like it regulates iron absorption. And when I first found out about that, it's just a good example of, you know, things are being regulated. Like you were saying, the body has this natural intuition and desire to thrive. And so we could be thinking we're doing something, but it might not actually be what manifests because of these hormones at play. I tried to get my doctor to order that and he hadn't even heard of it and said he couldn't order it.

Dr. Naomi Parrella:
Yeah. Well, it is interesting because some tests that we do that people will come in and say things like, can you test my cortisol? Yes, I can test your cortisol and I can tell you what your cortisol is, but it tells you one moment in time, right? And are you going to change all of your behaviors because of a one moment cortisol test? Meaning at that moment, the stress hormone, where was it? Your life changes on a minute to minute basis. And this is one of the challenges is many people get caught up in one specific lab and they freak out. And understandably, I mean, I was one of those people too. I had to go to med school so I could feel better about it. But I think the most important thing is starting to recognize and appreciate the body changes and adapts to what it's trying to survive. It's trying to make it better for you. And that's why we adapt and get stronger. That's why we adapt and have better immune systems and so on. So yeah, it is hard because we don't know what to do with some of the labs that we get.

Melanie Avalon:
And so speaking of broader picture and, you know, tracking things beyond a single moment, how did you get acquainted with zero?

Dr. Naomi Parrella:
Oh yeah. So like I said, seeing so many patients, they teach you, right? So I remember, gosh, I don't even know how many years ago, but it was actually pre-COVID several years. I had a patient come in and we were doing instrument fasting for this patient's protocol, and they were having wild success. And I said, what's helping with your success? I'm always so curious. They said, oh, you know, there's this new app and it's called Zero. So I, of course, promptly had to download it and try it out. So since then, I have recommended and used it with patients over the years and through COVID, it was particularly helpful, especially when there were times of, you know, food shortages or concerns with the safety of different foods, you know, does the groceries have bugs, you know, whatever. And so it turned out to be really, really useful because there's a way to anchor and stay okay. And so then, you know, a little over a year ago, a year ago, the leadership team at Zero reached out and we connected. And so that was, you know, when I decided to join on and I've been super thrilled to see all these brilliant people both at the company and all of our users who have continued to give great feedback and inform us. And so it's really wonderful to have empowered individuals altogether, you know, sharing their information, sharing their data, and being excited about it.

Melanie Avalon:
Okay, I have questions. I'm fascinated by app development and everything. So, because now that you're mentioning that, I can see where I was in my life when I first used it. And it was in the beginning of COVID, I believe. So I, you know, looked at it recently in preparation for our interview. And it's changed a lot since I used it. It was a lot simpler. So your role in the company, how much of it is you informing the company versus you analyzing the data and learning? Like, what's the relationship there?

Dr. Naomi Parrella:
Yeah. So, I mean, it's actually quite a brilliant team. And so everybody's been really diving deep into the research, each individual person, you know, as far as I can tell, everybody lives what we preach, right? So that's really, really cool. So I am actually probably doing more of the science review. And, you know, when possible, I try to give some feedback with regards to different content that we might consider in the future or whatever, based on what my patients are saying. So it's actually really more around the science. I'm not looking at any of the data unless somebody sends it to us, right? So that's really, right now, I'm more involved in the science end and understanding how to best help people and provide the information in a simplified way. I just like to make it really easy. You know, I know there's some people who want to use big words and make it really complex. It's just not that complex, right? We want to make it simple and easy so that you can live your life and enjoy.

Melanie Avalon:
Okay, awesome. So yeah, that was one of the things I was thrilled to see was, you know, all of these articles and so do you actually part? Okay, because you're my favorite person ever you have a there's a right now on the homepage, there's something from Peter to yet, like, does that actually partnering with him to create content for

Dr. Naomi Parrella:
So he was one of the brilliant people who at the start of Zero, I'm not sure how exactly he got involved or if he was one of the original individuals, but he obviously created fabulous content and knew there was a need. So currently he's not communicating with us about the app, he's got many more things to do.

Melanie Avalon:
Okay, so he was though in partnership, yeah.

Dr. Naomi Parrella:
Yeah, yes, absolutely.

Melanie Avalon:
Yeah, that's amazing. I'm super curious the app, because it says it'll indicate sort of your fat burning status. What are your thoughts on that, especially when we're talking earlier about how people are all individual, like do people enter the fat burning state at the same time? How can we how can we know what's actually happening in a person's metabolism?

Dr. Naomi Parrella:
Yeah, this is what I mean by like genius people at the company. So they have over time, you know, put together both with the research and data analytics and so on been able to create a formula that really takes your information. So in the app, you can have it so that let's say your Apple health kit automatically feeds information into the app, any data that you are willing to share with yourself in the app and put in one place, then a mathematical formula calculates and helps determine that. So, you know, it'll take into account like if you had an aura ring, it'll take into account your physical activity and so on. So that's how that's done. That's how it's individualized.

Melanie Avalon:
Yeah, I was wondering, when you sign up, you ask your age and sex and everything. So I'm guessing it takes that into account to figure out as well.

Dr. Naomi Parrella:
Absolutely. Yep. And I think, you know, now that we have more and more sensors that are becoming available, over time, I think the information is going to get even better and better. Right. So right now, yes, you can get continuous glucose monitor, but there's continuous lactate monitors coming, right? There's so many, like, new measurements that can help us more finally figure out, okay, this is what's going on for you. Oh, your ketones are up. Okay, you are burning fat, you know what I mean?

Melanie Avalon:
Yeah, awesome. We love cgms on this show. We talk about them all the time. Oh good me too big fans

Dr. Naomi Parrella:
Yes, they're so useful for so many people for learning.

Melanie Avalon:
I know if everybody, I honestly think if everybody did a CGM at least just once, it would just open the eyes. I think it would change the metabolic health of, you know, at least the US if everybody just did it once, you know.

Dr. Naomi Parrella:
Yeah. Yeah. You just really only need that two-week window to just kind of check it out and see how your behaviors are. And it is pretty interesting. But I, you know, I don't know if you found this, but I find some people, their sugars are pretty solid, like they're like a line, right? So they're not fluctuating that much. And when that happens, you know, then I'll have people come in and say, well, that wasn't very useful for me. Like, oh my gosh, but you're metabolically so healthy.

Melanie Avalon:
Oh, that's, you know, that's true. So with all the people, metabolically unhealthy people did it at least once. And so, so the actual content that you are reviewing in the app, have you seen any content that you have felt the need to update or change based on the science or how does it evolve?

Dr. Naomi Parrella:
Yeah, we're definitely constantly updating and I think that's part of the fun of the whole team. So we'll post different research or we'll talk about what, you know, if people are struggling. This is why feedback is so helpful. So, you know, ask zero and send a note or question or comment. It helps us to fine tune and figure out, oh, okay. Because there's so much content now that, you know, sometimes we forget what's out there already. And so we have to like pull it in review and adjust. But so far, you know, other than things like, you know, protein dosing, right, that you don't need to have, you know, so many times of eating protein, you could do it in a short window, that type of stuff. Yeah, we definitely have to keep up to date on all of that. And of course, with these new medications, which are really changing the scene, I particularly interested in individuals who've been on or are on these injectable weight loss medications. We want to make sure, you know, we could help those individuals, for example, if they can't get their medicine or they're starting to have weight regain after they come off or something to that effect. I want to make sure we provide content around that and keep that up to date as well.

Melanie Avalon:
Awesome. Yeah. Do you experience with your clients and patients weight regame issues or are they able to maintain after semi-glutide and osympic and things?

Dr. Naomi Parrella:
Yeah. So, so far, you know, the literature has been pretty clear and patient experiences are that most people will regain the weight if they come off the medicine. So, you know, there's different things people are trying. Do you use different medicines? Do you do a medication vacation and then restart? Do you sort of wean down? And then if the weight regain happens, you go back up. So, there's lots of different things happening. But what we're finding is it really, really matters if you've lost mostly fat or if you've also lost muscle. If you've lost muscle, we're in trouble, right? We are going to need to really be very careful about how we replenish nutrients. You know, again, this gets to the mTOR, the AMP kinase, like, you know, there's like a whole thing there. So, but we want to make sure we take care of people and help them, you know, stay as healthy as possible wherever they're at.

Melanie Avalon:
Awesome. Well, when I'm, um, when I was in the app and it prompts you to subscribe and get the, the plus version, which gives you more access to more of the information or like the science information and everything it says, I mean, I'm assuming this is true. It says that the people who are in plus reach their goals two times faster. Do you think that's because of the exposure to all of the, like the information in the app or is there something else going on there?

Dr. Naomi Parrella:
Absolutely. So there's two things, right? One is that commitment to yourself. And, you know, sometimes that's enough. Tracking, we know that tracking makes a massive difference, right? That's also super important. And then thirdly, education and knowledge, the more you understand, you can't like unknow something once you know it, right? So if you learn something, and it is like fundamentally different than what you understood before, it changes how you approach, let's say, eating, or your physical activity, or, you know, your life. And it has this wonderful effect of just keeping it in your forebrain, right? So just by engaging, you're already making a commitment to yourself, you're already carving out a second of your time to just take care of you. And so I think there's multiple factors in there. But it is really impressive how responsive just making that decision is.

Melanie Avalon:
I know I love that so much and honestly, I'm going to start recommending this a lot because we talk on the show a lot about the role of tracking because a lot of people, especially with diet people, sometimes they don't want to get into diet mindset and they don't want to track and all of that, which I completely understand and want to support as well. And so something I like to say to people is you can actually, in a way, divorce the tracking of calories from the actually monitoring of calories and what I, or sorry, from actually changing what you eat. And what I mean by that is we know there's this observer effect where like you just said, just the act of tracking tends to make people lose weight and eat less without even meaning to. So instead, you know, like with the, and it's one of the, you know, issues with studies like and controlling them because yeah, that's exactly right. So I'll talk about that, but I haven't, honestly, in the seven years of this show, I don't think I've talked a lot about having an actual intense accountability tracker for the actual fasting aspect of it. So yeah, this is, this is really, really great. So do you use it daily?

Dr. Naomi Parrella:
Yeah. So I go through cycles. It's my most favorite reset tool. So if I've been off track or my life is just a little bit crazy, then it's really helpful to ground me and to make sure I'm paying attention to myself and the signals I'm giving to my body. So it's super, super helpful. Are there times I'm not using it? Absolutely. When I'm crushing it, I'm already in a good space. You know, I'm not having a scheduled disruption for sure. But what I like about it is I can track so many different things. But even just with the fasting timer, I can use that for example, like I might already have my fasting, you know, window and I'm doing that fine. But I might notice, you know what, I'm starting to eat a little bit not so great. You know, a little bit of these, you know, sweets have entered or salty, salty is usually my thing. And I want to get back on track. And, you know, since I had a celebration weekend, you know, I'm a little bit not focused, I'm still doing the fasting time, but I'm not eating what I want in that eating window. So then I'll use the fasting timer to for example, fast from fried foods or sweets or whatever it is. And I use it that way for that time period. Yeah. And so it helps me reset and just recalibrate. And if I didn't have that, you know, I could do it, but it would take up brain space. And I don't want to use my brain space for that. I want to, you know, do my life. And so that's how I'll use that as well.

Melanie Avalon:
Can you, so if you're doing that where you're accounting the fasting from a certain food, can you tell it that's what you're doing or does it think that you are fasting, fasting?

Dr. Naomi Parrella:
Right now you can't tell it what you're doing. It will think you're fasting. And so I will know what I'm trying to do in that time period.

Melanie Avalon:
Okay. Gotcha.

Dr. Naomi Parrella:
I'll put a little marker for you can write little notes.

Melanie Avalon:
Okay, very, very cool.

Dr. Naomi Parrella:
Because I'll already know, for example, that I'm doing a 16 .8, right? Most of the time, that's what I'm doing. And then there'll be times when I go down to 12 and times when I extend it longer. That's awesome.

Melanie Avalon:
And then the powerful, I love that there's the calendar for the streaks, because there's something really powerful about streaks. I mean, I do that like old school for some things, like with like a calendar and stickers. Me too.

Dr. Naomi Parrella:
I do. I'm totally into that. It's so fun. I'm like, oh my gosh, I'm in first grade again.

Melanie Avalon:
You get to put the sticker every night. It's so exciting. And what I did is I got this sheet of stickers, and every single one is a quote about abundance. And so it's like a meditation moment every night or a mindfulness moment where I like, yeah, it's a whole thing. I highly recommend.

Dr. Naomi Parrella:
Well that's so great especially if you're doing that at night because of course if you do something like mine fall it boost that btnf right that brain derived neurotrophic factor so you're and then you go to bed that's like so what a bonus.

Melanie Avalon:
I love this. This is amazing. So what are you most excited about with the future of this app?

Dr. Naomi Parrella:
You know, I'm really excited about we're continuing to modify this experience for people so that we can meet them where they are and give them an experience of wild success with their own body, right? So again, personalizing it, figuring out what's going to make the difference and simplifying it as much as possible. Life is busy, right? Everybody's got other things they want to do. So we want to make it so, so easy to take great care of yourself and make it. Like, you know, just a little thing, but have a powerful impact, you know, helping the gut, the brain, the metabolism, the waistline, you know, all those things. So I think that's what I'm really excited about is trying to find better and better ways to make this possible for more people because that's our ultimate goal, right? Help as many people as possible live, you know, their life with, you know, health, longevity, this vitality that we all love.

Melanie Avalon:
I love this. Well, I'm just so, so grateful for this resource for people. So for listeners, again, you can go to ifpodcast.com/zero, and you can get a seven day free trial of zero of the plus version. And then you can always keep using it, not the plus version, or you can upgrade and get that version to stay. Okay, two really last quick questions for you. One is if you could design if you had unlimited funds and resources and all the things and you could design any study about fasting, what would you do or test?

Dr. Naomi Parrella:
Oh wow, I want to ask you, what would you want tested?

Melanie Avalon:
I don't know if this is like the thing I would do if I had more time to think about it, but something I would love to do is I think I've come up with a way to test sort of like the placebo effect with fasting. Basically, I think they should do some trials where they tell the people they're testing a pill and the pill is not a sugar pill because I would mess things up. It has to be like a cellulose pill. And then they would tell the people that this pill can't be taken with food and you can't eat a certain amount of time before or after. So, then it would make people fast without realizing that they're testing fasting. I would just like some studies to use that setup because it would kind of like trick people into fasting and I think there's a lot of like potential there for looking at placebo effects and stuff.

Dr. Naomi Parrella:
Oh, wow. Yeah, that is super. That's a very interesting thought.

Melanie Avalon:
Like you could say it has to be taken in the morning and then you can't eat for X amount of hours and so that would you could force people into a long fast.

Dr. Naomi Parrella:
That's true. That's true. Although I'm curious because a lot of people won't follow the rules. So we'd have to monitor.

Melanie Avalon:
You have to have them on like on like cgms on them and stuff. I know

Dr. Naomi Parrella:
that is a really interesting study and I'm very curious about that. That's a great idea.

Melanie Avalon:
Yeah, that's more a mechanism of study, but I don't know what I would do for like, actually testings. There's so many things. I think one of the things I'm haunted by is I really want to know, because I know speaking of Peter, I don't know if he's changed his mind, but he'll often say that effects of fasting are due to calorie restriction. And I would like more comparisons of calorie restriction and fasting to see if that is the sole reason or if it's something else.

Dr. Naomi Parrella:
That's interesting because fasting does cause decrease in calorie intake, right? So is in it, I think it depends on what you're eating in your eating window, because if you are tapping into fat burning because your insulin comes down because you're fasting, yeah, you're gonna end up eating less and not wanting to eat more. That's the key, right? So or is it that you're not tapping into fat burning and you're starving and you want to eat something, but you're starving your body because the time's not up, right? This is exactly, that's exactly the point. So, you know, why is somebody eating that amount of calories? Whether it's a lot or a little, if it's because their body's hormone setup is set up that way, then that's in alignment with the body. But it's not in alignment if you're forcing the calorie restriction by force. That's why the fasting is so interesting because some people do it where they force themselves and some people actually, after a while, they're like, oh, no, I actually am fine. And it's because the body can actually fuel off the fat cells.

Melanie Avalon:
Yeah, exactly. We didn't even talk about it. I know in your, in the input form, but you had something about cracking the circadian code. I would love more studies on, cause I'm such a late night eater. Are you, are you a late night or earlier when do you

Dr. Naomi Parrella:
I'm definitely not a morning person for sure. I'm with you.

Melanie Avalon:
So I would love more studies, like really controlled studies on actual fasting with late night eating because I have controversial thoughts on this.

Dr. Naomi Parrella:
Well, you know, what's interesting is there are studies that show when people eat at a certain time and then they change it. So let's say you do eat late at night, but then you go into a new fasting pattern where you don't eat at night and you actually eat early in the day. So you shift your fasting time. It does have a metabolic effect. And so, you know, that's really, really interesting because it goes both ways. So I think, again, the human body is designed to, you know, make you be the best you. And first it's about survival. So if it has to protect you, it's going to start storing everything. If it feels like there's abundance and it can tap into all the fuels, then it can burn freely and give you all the energy you want and be able to do all of that.

Melanie Avalon:
So this is the last question that I ask actually on my other show, but I'm gonna bring it into this show because we don't normally have guests on this show. And it's just because I realize more and more each day how important mindset is. So what is something that you're grateful for?

Dr. Naomi Parrella:
Oh gosh, there's so many things. I'm grateful, actually, that you're running this podcast and that you're sharing information for the world to hear. I'm grateful that we actually have opportunities to share this information broader with all the new technologies available. And I'm grateful that people are curious and seeking this knowledge and that they're able to access some very, very new ideas and that we're learning. It's not that we just didn't have enough discipline, right? It's actually much more complicated than that and the body is super fabulous and it's able to take care of you.

Melanie Avalon:
Well, thank you so much, Dr. Perilla. I am so, so grateful for what you're doing. It was so thrilling to be introduced to you, and it's really nice to know there's somebody like you. And it sounds like, from what you're saying, the rest of the company is amazing as well. But it's great to know that this is the team behind this app. It makes me feel really grateful and so excited to recommend it to everybody. So everybody, again, go to ifpodcast.com/zero. Get this app now. And yeah, thank you so much for everything. I really, really enjoyed this. This was so delightful. Is there anything else you want to say, any links you want to put out there, anything else for the listeners?

Dr. Naomi Parrella:
Melanie, I'm so grateful, like I said, for what you're doing and the messaging that you're giving to people to empower them. So thank you so much. I think the most wonderful gift is seeing the ripple effect. So you talk to one person, their lives change, and then it goes on and they spread that. And so I'm super grateful about that. And I think right now, I'm learning how to do Instagram. I'm really late to the show here. So I'm going to try to also start developing ripples like that. And I'm really grateful for this opportunity to talk with you. Thank you so much.

Melanie Avalon:
No, I'll just say really quickly, I was late to the Instagram game too and I was like really intimidated. It's awesome. You got this. It'll be great. Thank you for that. Thank you. Thank you. Yeah. All right. Awesome. We'll have a good rest of your evening and I will talk to you later. Bye. All right. Thank you so much, Melanie. Bye-bye.

Melanie Avalon:
Thank you so much for listening to the Intermittent Fasting Podcast. Please remember, everything we discussed on this show does not constitute medical advice and no patient-doctor relationship is formed. If you enjoyed the show, please consider writing a review on iTunes. We couldn't do this without our amazing team. Editing by Podcast Doctors, show notes and artwork by Brianna Joyner, and original theme composed by Leland Cox and recomposed by Steve Saunders.

Check out the Stuff We Like page for links to any of the books/supplements/products etc. mentioned on the podcast that we like!

More on Vanessa: ketogenicgirl.com

Original theme composed by Leland Cox and recomposed by Steve Saunders.

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